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51. Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)

Author

PIGNATA S, GALLO C, DANIELE B, ELBA S, GIORGIO A, ADINOLFI LE, SIO I, IZZO F, FARINATI F, DEL NAJA C, STANZIONE M, MARONE G, CUOMO O, FELDER M, GAETA GB, DE MAIO E, DI MAIO M, SIGNORIELLO G, PERRONE F, CLIP INVESTIGATORS, CAPUANO, GAETANO, CASTIGLIONE, FABIANA, Pignata, S, Gallo, C, Daniele, B, Elba, S, Giorgio, A, Capuano, Gaetano, Adinolfi, Le, De, Sio, I, Izzo, F, Farinati, F, DEL NAJA, C, Stanzione, M, Castiglione, Fabiana, Marone, G, Cuomo, O, Felder, M, Gaeta, Gb, DE MAIO, E, DI MAIO, M, Signoriello, G, Perrone, F, and Clip, Investigators

Published
2006

52. Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype

Author

Anzilotti, S, primary, Tornincasa, M, additional, Gerlini, R, additional, Conte, A, additional, Brancaccio, P, additional, Cuomo, O, additional, Bianco, G, additional, Fusco, A, additional, Annunziato, L, additional, Pignataro, G, additional, and Pierantoni, G M, additional

Published
2015
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54. D-MELD, a Powerful Instrument To Optimize Donor-2-Recipient Match. Differences between US and Italy

Author

Avolio, A., Halldorson, J., Lirosi, M., Agnes, S., Salizzoni, Mauro, Pinna, A., Spada, M., De Carlis, L., Colledan, M., Gerunda, G., Andorno, E., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Vivarelli, M., Lupo, L., Cuomo, O., Calise, F., Nicolotti, N., Vitale, A., Romagnoli, Renato, Cucchetti, A., Bonsignore, P., Mangoni, I., Pinelli, D., Montalti, R., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Santaniello, W., Bottino, G., Spagnoletti, G., Mariano, G., Gasbarrini, A., Burra, P., Cillo, U., and Donor to Recipient, Italian Liver Transplant Study Group

Subjects
Liver transplantation, Liver transplantation, D-MELD, D-MELD
Published
2013

55. Recenti risultati delle ricerche alla Grotta del Pino (Sassano, Salerno)

Author

Piperno M., Pellegrini E., Di Maio G., Santangelo N., Santo A., Vagnetti L., Spadacenta B., Cuomo O., Gallotti R., Levi S. T, Jones R. E., FABBRI, Pier Francesco, Piperno, M., Pellegrini, E., Fabbri, Pier Francesco, Di Maio, G., Santangelo, N., Santo, A., Vagnetti, L., Spadacenta, B., Cuomo, O., Gallotti, R., Levi S., T, and Jones, R. E.

Subjects
Pino, Eneolitico, Antropologia, Archeometria
Abstract

In seguito alla scoperta fortuita nel 1994 della grotta del Pino, situata nel tratto meridionale del Vallo di Diano, nel comune di Sassano (SA), la cavità è stata al centro di due campagne di scavo e di numerosi sopralluoghi effettuati tra il 1997 e il 1998. In questa sede sono esposti i risultati scaturiti da questa articolata indagine condotta sul campo in stretta collaborazione tra paletnologi ed esperti di scienze della terra, antropologi e paleontologi, ai quali si è aggiunto il contributo di specialisti relativamente all’inquadramento delle ceramiche di tipo egeo e alle analisi archeometriche ad esse pertinenti. Sulla base delle prime risultanze della ricerca è stato evidenziato un carattere prevalentemente funerario della frequentazione della grotta associato a complesse pratiche rituali. L’esame dei materiali ceramici rinvenuti ha consentito di circoscriverne la frequentazione ad un arco cronologico compreso tra la fase non iniziale dell’Eneolitico ed il Bronzo medio iniziale (Protoappenninico B), mentre episodico è apparsa l’utilizzazione come luogo di sepoltura nel VII sec. a.C. Alla frequentazione dell’età del Bronzo medio iniziale, assai più consistente di quella dell’Eneolitico e dell’antica età del Bronzo, possono essere assegnati diversi frammenti ceramici in argilla depurata di tipologia egea, alcuni dei quali con decorazione dipinta a vernice bruna.

Published
2001

56. Graft survival is worse in HCV positive females transplanted with male donor grafts

Author

Belli, L., Romagnoli, Renato, Rossi, M., Gerunda, Ge, Pinna, Ad, Agnes, S., Spada, M., Colledan, M., Tisone, G., Decarlis, L., Baccarani, U., Mazzaferro, V., Ettorre, Gm, Cillo, U., Calise, F., Cuomo, O., Lupo, L., Ginanni Corradini, S., Zamboni, F., Marianelli, T., Risaliti, A., Patrono, Damiano, Li Petri, S., Tagliabue, F., Jme, Mangoni, Antonelli, B., Sposito, C., Gringeri, E., Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., and Angelico, M.

Subjects
HCV infection, liver transplantation
Published
2012

57. Graft survival is worse in HCV positive females transplanted with male donor grafts L

Author

Belli, Romagnoli, R., Rossi, M., Gerunda, G. E., Pinna, A. D., Agnes, S., Spada, M., Colledan, M., Tisone, G., De Carlis, L., Baccarani, U., Mazzaferro, V., Ettorre, G. M., Cillo, Umberto, Calise, F., Cuomo, O., Lupo, L., Ginanni Corradini, S., Zamboni, F., Marianelli, T., Risaliti, A., Patrono, D., Li Petri, S., Tagliabue, F., Mangoni, J. M. E., Antonelli, B., Sposito, C., Gringeri, Enrico, Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., Angelico, M., Italian Liver Ctrs, for the Liver Match i. n. v. e. s. t. i. g. a. t. o. r. s., Italian Association for the Study of the Liver, Dept, Mathematics, Tor Vergata Univ, and Rome

Published
2012

58. Behind D-MELD: the role of primary indication (HCV or HBV) as significant covariate in the outcome prediction after liver transplants

Author

Avolio, A., Agnes, S., Lirosi, M., Salizzoni, Mauro, Pinna, Ad, Gridelli, B., Decarlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Vitale, A., Nicolotti, N., Romagnoli, Renato, Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, F., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., de Waure, C., Angelico, M., Burra, P., Fagiuoli, S., Toniutto, P., Gasbarrini, A., and Cillo, U.

Subjects
liver transplantation, D-MELD
Published
2012

59. Behind D-MELD: The Role of Primary Indication (HCV or HBV) as Significant Covariate in the Outcome Prediction after Liver Transplants

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G., Valente, U., Rossi, G., Ettorre, G., Risaliti, A., Mazzaferro, V., Rossi, Massimo, Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Nicolotti, N., Vitale, A., Romagnoli, R., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Burra, P., Gasbarrini, A., Cillo, U., and Donor To Recipient Italian Liver, T.

Subjects
d-meld
Published
2012

60. Use of HBCAB positive liver organs. Medium term results: according to the Donor –Recipient risk factors

Author

Avolio, A. W., Agnes, S., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R., Lupo, F., Cucchetti, A., Gruttadauria, Salvatore Giovanni, Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Barone, M., Perrella, A., Romano, M., de Waure, C., Burra, P., Gasbarrini, A., and Cillo, U.

Published
2011

61. Balancing Donor and Recipient Risk Factors in Liver Transplantation: The Value of D-MELD in Particluar Reference to a HCV Recipients

Author

Avolio, Aw, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, Ge, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, N, Burra, P, Gasbarrini, A, Agnes, S, Lirosi, Mc, Miele, L, Pompili, M, Siciliano, M, Perilli, V, Gaspari, R, Castagneto, M, Tandoi, F, Mangoni, I, Belli, L, Pinna, Ad, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Fagiuoli, S, Montalti, R, Regalia, E, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, V, Ettorre, Gm, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, Pl, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, De Ville De Goyet, J, Monti, L, and De Waure, C.

Published
2011

63. WWW.D-MELD.COM THE PROGNOSTIC CALCULATOR TO BALANCE DONOR AND RECIPIENT LIVER TRANSPLANT FACTORS USING D-MELD AND COVARIATES

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R, Lupo, F., Cucchetti, A., Gruttadauria, S., Mangoni, I., Pinelli, D., Montalti, R, Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Perrella, A., Scuderi, E., Antonelli, B., de Waure, C., De Feo, T., Burra, P., Gasbarrini, A., and Cillo, U.

Published
2011

64. Optimization of donor recipient match and identification of the futile match cutoff a national italian study on liver transplantation

Author

Avolio, A. W., Agnes, S., Lirosi, M. C., Salizzoni, M., Pinna, A. D., Gridelli, B., De Carlis, L., Colledan, M., Gerunda, G. E., Valente, U., Rossi, G., Ettorre, G. M., Risaliti, A., Mazzaferro, V., Bresadola, F., Rossi, M., Tisone, G., Zamboni, F., Lupo, L., Cuomo, O., Calise, F., Donataccio, M., Nicolotti, N., Vitale, A., Romagnoli, R., Lupo, F., Cucchetti, A., Gruttadauria, Salvatore Giovanni, Mangoni, I., Pinelli, D., Montalti, R., Gelli, M., Caccamo, L., Vennarecci, G., Nicolini, D., Regalia, E., Baccarani, U., Lai, Q., Manzia, T., Tondolo, E., Rendina, M., Barone, M., Perrella, A., Romano, M., de Waure, C., Burra, P., and Gasbarrini, A.

Published
2011

66. Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism

Author

Formisano, L., primary, Guida, N., additional, Valsecchi, V., additional, Cantile, M., additional, Cuomo, O., additional, Vinciguerra, A., additional, Laudati, G., additional, Pignataro, G., additional, Sirabella, R., additional, Di Renzo, G., additional, and Annunziato, L., additional

Published
2015
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67. Il D-MELD espressione del match donatore-ricevente. Analisi retrospettiva multicentrica italiana relativa al periodo 2002-2009

Author

Avolio, A., Agnes, S., Cillo, U., Vitale, A., Lirosi, M. C., Salizzoni, M., Romagnoli, R., Lupo, L., Pinna, A., Cucchetti, A., Pinelli, D., Colledan, M., Gerunda, G., Montalti, R., Gridelli, B., Gruttadauria, Salvatore Giovanni, De Carlis, L., Mangoni, I., Valente, U., Gelli, M., Mazzaferro, V., Regalia, E., Ettorre, G., Vennarecci, G., Lai, Q., Rossi, M., Tisone, G., Sforza, D., Nicolini, D., Risaliti, A., Cuomo, O., Perrella, A., Tondolo, V., Zamboni, F., Rossi, G., Caccamo, L., Rendina, M., Bresadola, F., Baccarani, U., Donataccio, M., Dalle, O., Romano, M., Calise, F., Nicolotti, N., and de Waure, C.

Published
2010

68. Il graft HBcAb+ nella esperienza trapiantologica italiana (2002-2009). Analisi retrospettiva in rela-zione all’effetto centro ed all’epoca di effettuazione del trapianto

Author

Avolio, A., Cillo, U., Salizzoni, M., Pinna, A., Colledan, M., Gerunda, G., Gridelli, B., De, C., Valente, U., Mazzaferro, V., Ettorre, G., Rossi, M., Tisone, G., Risaliti, A., Cuomo, O., Zamboni, F., Rossi, G., Lupo, L., Bresadola, F., Donataccio, M., Calise, F., Nicolotti, N., Nure, E., Vitale, A., Romagnoli, R., Cucchetti, A., Pinelli, D., Montalti, R., Gruttadauria, Salvatore Giovanni, Mangoni, I., Gelli, M., Regalia, E., Vennarecci, G., Lai, Q., Sforza, D., Nicolini, D., Perrella, A., Tondolo, V., Caccamo, L., Rendina, M., Baccarani, U., Dalle Ore, G., Romano, M., de Waure, C., and Agnes, S.

Published
2010

72. Results of a multicenter, randomized, open-label, controlled clinical trial comparing basiliximab versus steroids in Hepatitis C positive liver transplant patients

Author

Search De Simone, P., Search De Carlis, L., Search Filipponi, F., Search Grazi, G. L., Search Cuomo, O., Search Santaniello, W., Search Magalini, S. C., Search Valente, U., Search Salizzoni, M., Search Bresadola, F., Rossi, Massimo, Search, M., Search Burra, P., Massimo, Rossi, Search, G., Search Cillo, U., Search Ferrara, R., and Corbetta, G.

Subjects
basiliximab, steroids
Published
2007

81. Balancing Donor and Recipient Risk Factors in Liver Transplantation: The Value of D-MELD With Particular Reference to HCV Recipients

Author

Avolio, Alfonso Wolfango, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, Ge, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, Nicola, Burra, P, Gasbarrini, Antonio, Agnes, Salvatore, Lirosi, Mc, Miele, Luca, Pompili, Maurizio, Siciliano, M, Perilli, Valter, Gaspari, Rita, Castagneto, M, Tandoi, F, Mangoni, I, Belli, L, Pinna, Ad, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, Stefano, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, Vincenzo, Ettorre, Gm, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, Pl, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, de Ville de Goyet, J, Monti, L, De Waure, Chiara, Avolio, AW (ORCID:0000-0003-2491-7625), Nicolotti, N, Gasbarrini, A (ORCID:0000-0002-7278-4823), Agnes, S (ORCID:0000-0002-3341-4221), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Perilli, V (ORCID:0000-0001-9655-4267), Gaspari, R (ORCID:0000-0003-0141-3686), Fagiuoli, S, Tondolo, V (ORCID:0000-0003-0256-3766), de Waure, C (ORCID:0000-0002-4346-1494), Avolio, Alfonso Wolfango, Cillo, U, Salizzoni, M, De Carlis, L, Colledan, M, Gerunda, Ge, Mazzaferro, V, Tisone, G, Romagnoli, R, Caccamo, L, Rossi, M, Vitale, A, Cucchetti, A, Lupo, L, Gruttadauria, S, Nicolotti, Nicola, Burra, P, Gasbarrini, Antonio, Agnes, Salvatore, Lirosi, Mc, Miele, Luca, Pompili, Maurizio, Siciliano, M, Perilli, Valter, Gaspari, Rita, Castagneto, M, Tandoi, F, Mangoni, I, Belli, L, Pinna, Ad, Cescon, M, Gridelli, B, Li Petri, S, Volpes, R, Pinelli, D, Fagiuoli, Stefano, Montalti, R, Regalia, E, Rossi, G, Antonelli, B, Berloco, P, Lai, Q, Risaliti, A, Nicolini, D, Valente, U, Gelli, M, Morelli, N, Zamboni, F, Tondolo, Vincenzo, Ettorre, Gm, Vennarecci, G, Bresadola, F, Baccarani, U, Toniutto, Pl, Manzia, T, Anselmo, A, Angelico, M, Calise, F, Scuderi, V, Romano, M, Rendina, M, Barone, M, Cuomo, O, Perrella, A, Santaniello, W, Donataccio, M, Dalle Ore, G, de Ville de Goyet, J, Monti, L, De Waure, Chiara, Avolio, AW (ORCID:0000-0003-2491-7625), Nicolotti, N, Gasbarrini, A (ORCID:0000-0002-7278-4823), Agnes, S (ORCID:0000-0002-3341-4221), Miele, L (ORCID:0000-0003-3464-0068), Pompili, M (ORCID:0000-0001-6699-7980), Perilli, V (ORCID:0000-0001-9655-4267), Gaspari, R (ORCID:0000-0003-0141-3686), Fagiuoli, S, Tondolo, V (ORCID:0000-0003-0256-3766), and de Waure, C (ORCID:0000-0002-4346-1494)

Abstract

Donorrecipient match is a matter of debate in liver transplantation. D-MELD (donor age x recipient biochemical model for end-stage liver disease [MELD]) and other factors were analyzed on a national Italian database recording 5946 liver transplants. Primary endpoint was to determine factors predictive of 3-year patient survival. D-MELD cutoff predictive of 5-year patient survival <50% (5yrsPS<50%) was investigated. A prognosis calculator was implemented (). Differences among D-MELD deciles allowed their regrouping into three D-MELD classes (A < 338, B 338-1628, C >1628). At 3 years, the odds ratio (OR) for death was 2.03 (95% confidence interval [CI], 1.442.85) in D-MELD class C versus B. The OR was 0.40 (95% CI, 0.24-0.66) in class A versus class B. Other predictors were hepatitis C virus (HCV; OR = 1.42; 95% CI, 1.11-1.81), hepatitis B virus (HBV; OR = 0.69; 95% CI, 0.51-0.93), retransplant (OR = 1.82; 95% CI, 1.16-2.87) and low-volume center (OR = 1.48; 95% CI, 1.1-11.99). Cox regressions up to 90 months confirmed results. The hazard ratio was 1.97 (95% CI, 1.592.43) for D-MELD class C versus class B and 0.42 (95% CI, 0.290.60) for D-MELD class A versus class B. Recipient age, HCV, HBV and retransplant were also significant. The 5yrsPS<50% cutoff was identified only in HCV patients (D-MELD = 1750). The innovative approach offered by D-MELD and covariates is helpful in predicting outcome after liver transplantation, especially in HCV recipients.

Published
2011

82. Liver Match, a prospective observational cohort study on liver transplantation in Italy: study design and current practice of donor-recipient matching

Author

Angelico, M, Cillo, U, Fagiuoli, S, Gasbarrini, A, Gavrila, C, Marianelli, T, Costa, A, Nardi, A, Strazzabosco, M, Burra, P, Agnes, S, Baccarani, U, Calise, F, Colledan, M, Cuomo, O, DE CARLIS, L, Donataccio, M, Ettorre, G, Gerunda, G, Gridelli, B, Lupo, L, Mazzaferro, V, Pinna, A, Risaliti, A, Salizzoni, M, Tisone, G, Valente, U, Rossi, G, Rossi, M, Zamboni, F, Liver Match, I, Costa, AN, DE CARLIS, LUCIANO GREGORIO, Ettorre, GM, Gerunda, GE, Liver Match Investigators, STRAZZABOSCO, MARIO, Angelico, M, Cillo, U, Fagiuoli, S, Gasbarrini, A, Gavrila, C, Marianelli, T, Costa, A, Nardi, A, Strazzabosco, M, Burra, P, Agnes, S, Baccarani, U, Calise, F, Colledan, M, Cuomo, O, DE CARLIS, L, Donataccio, M, Ettorre, G, Gerunda, G, Gridelli, B, Lupo, L, Mazzaferro, V, Pinna, A, Risaliti, A, Salizzoni, M, Tisone, G, Valente, U, Rossi, G, Rossi, M, Zamboni, F, Liver Match, I, Costa, AN, DE CARLIS, LUCIANO GREGORIO, Ettorre, GM, Gerunda, GE, Liver Match Investigators, and STRAZZABOSCO, MARIO

Abstract

BACKGROUND: The Liver Match is an observational cohort study that prospectively enrolled liver transplantations performed at 20 out of 21 Italian Transplant Centres between June 2007 and May 2009. Aim of the study is to investigate the impact of donor/recipient matching on outcomes. In this report we describe the study methodology and provide a cross-sectional description of donor and recipient characteristics and of graft allocation. METHODS: Adult primary transplants performed with deceased heart-beating donors were included. Relevant information on donors and recipients, organ procurement and allocation were prospectively entered in an ad hoc database within the National Transplant Centre web-based Network. Data were blindly analysed by an independent Biostatistical Board. RESULTS: The study enrolled 1530 donor/recipient matches. Median donor age was 56 years. Female donors (n = 681, median 58, range 12-92 years) were older than males (n = 849, median 53, range 2-97 years, p < 0.0001). Donors older than 60 years were 42.2%, including 4.2% octogenarians. Brain death was due to non-traumatic causes in 1126 (73.6%) cases. Half of the donor population was overweight, 10.1% was obese and 7.6% diabetic. Hepatitis B core antibody (HBcAb) was present in 245 (16.0%) donors. The median Donor Risk Index (DRI) was 1.57 (>1.7 in 35.8%). The median cold ischaemia time was 7.3h (≥ 10 in 10.6%). Median age of recipients was 54 years, and 77.7% were males. Hepatocellular carcinoma (HCC) was the most frequent indication overall (44.4%), being a coindication in roughly 1/3 of cases, followed by viral cirrhosis without HCC (28.2%) and alcoholic cirrhosis without HCC (10.2%). Hepatitis C virus infection (with or without HCC) was the most frequent etiologic factor (45.9% of the whole population and 71.4% of viral-related cirrhosis), yet hepatitis B virus infection accounted for 28.6% of viral-related cirrhosis, and HBcAb positivity was found in 49.7% of recipients. The median Model fo

Published
2011

84. Tamoxifen in treatment of hepatocellular carcinoma: a randomised controlled trial

Author

Daniele, B., Pignata, S., Cremona, F., Izzo, F., Parisi, V., Fiore, F., Vallone, P., Perrone, F., Monfardini, S., Adinolfi, L. E., Ragone, E., Ruggiero, G., Utili, R., Gaeta, G. B., Giolitto, G., Giusti, G., Caporaso, N., De Sio, I., Pasquale, G., Piccinino, F., Stanzione, M., Calandra, M., Castellano, L., Del Vecchio Blanco, C., Colurcio, R., Galanti, B., Russo, M., Palmentieri, B., D’Alfonso, M. Persico G., Gallo, C., Signoriello, G., Budillon, G., Capuano, G., Cimino, L., Belli, D. Pomponi G., Iannelli, A., Santangelo, M. L., Bianco, A. R., De Placido, S., Palmieri, G., Castiglione, F., Mazzacca, G., Rispo, A., D’Agostino, L., Mattera, D., Puzziello, Alessandro, Cuomo, O., Di Palma, M., Manno, E., Militerno, G., Arena, U., Di Fiore, G., Gentilini, P., Mazzanti, R., Farinati, F., Rinaldi, M., Coviello, A., Elba, S., Manghisi, G., Crispino, B., Laviscio, R., Piai, G., D’Angelo, V., Francica, G., Marone, G., Aiello, A., Ferraù, O., Freni, M. A., Aloisio, V., Giorgio, A., Perrotta, A., Felder, M., Zancanella, L., Belli, M., Colantuono, G., De Sena, G., Guardascione, F., Petrelli, G., Lamorgese, I. B., Manzione, L., Pedicini, T., and D’Aprile, M.

Published
1998

85. Antifungal prophylaxis with liposomal amphotericin B and caspofungin in high-risk patients after liver transplantation: impact on fungal infections and immune system.

Author

Perrella, A., Esposito, C., Amato, G., Perrella, O., Migliaccio, C., Pisaniello, D., Calise, F., Cuomo, O., and Santaniello, W.

Abstract

Antifungal prophylaxis may be required in high-risk patients undergoing liver transplantation and for that reason we aimed to verify its role and its related impact on the graft. From January 2006 throughout 2012, 250 liver transplants were evaluated and 54 patients identified as being at higher risk were randomly selected to undergo the following schedule: 28 patients received liposomal amphotericin B and 26 received caspofungin. We evaluated, throughout 12 months, renal and liver function tests, bacterial and fungal infection episodes, and intensive care unit (ICU) stay, as well as the Th1 and Th2 cytokine network. Differences were analyzed according to non-parametric tests (two-tailedpvalues). Neither of the groups showed episodes of invasive fungal infection during the 12 months follow-up; however, patients receiving prophylaxis with liposomal amphotericin B had reduced episodes of bacterial infections coupled with an improved immune system response compared with those receiving caspofungin. Finally, a reduced stay in the ICU was also observed. In conclusion, even if the results of liposomal amphotericin B and caspofungin prophylaxis strategies did not differ in terms of invasive fungal infection rate, patients receiving prophylaxis with liposomal amphotericin B had a reduced ICU stay and an improved Th2 status, as well as a reduced number of post-transplant bacterial infections. Further studies are required to better address and evaluate these findings. [ABSTRACT FROM AUTHOR]

Published
2016
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87. Can the Un-Sustainable Match Be Identified in Liver Transplant Population? Evidencies from the Italian Donor-2-Recipient D-Meld Study

Author

Avolio, A. W., primary, Agnes, S., additional, Lirosi, M. C., additional, Salizzoni, M., additional, Pinna, A., additional, Gridelli, B., additional, De Carlis, L., additional, Colledan, M., additional, Gerunda, G., additional, Valente, U., additional, Rossi, G., additional, Ettorre, G., additional, Risaliti, A., additional, Mazzaferro, V., additional, Bresadola, F., additional, Rossi, M., additional, Tisone, G., additional, Zamboni, F., additional, Lupo, L., additional, Cuomo, O., additional, Calise, F., additional, Vitale, A., additional, Nicolotti, N., additional, Romagnoli, R., additional, Cucchetti, A., additional, Gruttadauria, S., additional, Mangoni, I., additional, Pinelli, D., additional, Montalti, R., additional, Gelli, M., additional, Caccamo, L., additional, Vennarecci, G., additional, Nicolini, D., additional, Regalia, E., additional, Baccarani, U., additional, Lai, Q., additional, Manzia, T., additional, Tondolo, E., additional, Rendina, M., additional, Perrella, A., additional, Scuderi, E., additional, Antonelli, B., additional, de Waure, C., additional, Frongillo, F., additional, Burra, P., additional, Gasbarrini, A., additional, and Cillo, U., additional

Published
2012
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95. 206 THE UN-SUSTAINABLE MATCH IN HCV LIVER TRANSPLANT PATIENTS

Author

Avolio, A.W., primary, Agnes, S., additional, Lirosi, M.C., additional, Salizzoni, M., additional, Pinna, A., additional, Gridelli, B., additional, De Carlis, L., additional, Colledan, M., additional, Gerunda, G., additional, Valente, U., additional, Rossi, G., additional, Ettorre, G., additional, Risaliti, A., additional, Mazzaferro, V., additional, Bresadola, F., additional, Rossi, M., additional, Tisone, G., additional, Zamboni, F., additional, Lupo, L., additional, Cuomo, O., additional, Calise, F., additional, Vitale, A., additional, Nicolotti, N., additional, Romagnoli, R., additional, Cucchetti, A., additional, Gruttadauria, S., additional, Mangoni, I., additional, Pinelli, D., additional, Montalti, R., additional, Gelli, M., additional, Caccamo, L., additional, Vennarecci, G., additional, Nicolini, D., additional, Regalia, E., additional, Baccarani, U., additional, Lai, Q., additional, Manzia, T., additional, Tondolo, E., additional, Rendina, M., additional, Perrella, A., additional, Scuderi, E., additional, Antonelli, B., additional, de Waure, C., additional, Angelico, M., additional, Burra, P., additional, Gasbarrini, A., additional, and Cillo, U., additional

Published
2012
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96. OC-28 Behind D-MELD: the role of primary indication (HCV or HBV) as significant covariate in the outcome prediction after liver transplants

Author

Avolio, A., primary, Agnes, S., additional, Lirosi, M., additional, Salizzoni, M., additional, Pinna, A.D., additional, Gridelli, B., additional, De Carlis, L., additional, Colledan, M., additional, Gerunda, G., additional, Valente, U., additional, Rossi, G., additional, Ettore, G., additional, Risaliti, A., additional, Mazzaferro, V., additional, Rossi, M., additional, Tisone, G., additional, Zamboni, F., additional, Lupo, L., additional, Cuomo, O., additional, Calise, F., additional, Vitale, A., additional, Nicolotti, N., additional, Romagnoli, R., additional, Cucchetti, A., additional, Gruttadauria, S., additional, Mangoni, I., additional, Pinelli, D., additional, Montalti, F., additional, Gelli, M., additional, Caccamo, L., additional, Vennarecci, G., additional, Nicolini, D., additional, Regalia, E., additional, Baccarani, U., additional, Lai, Q., additional, Manzia, T., additional, Tondolo, E., additional, Rendina, M., additional, Perrella, A., additional, Scuderi, E., additional, Antonelli, B., additional, de Waure, C., additional, Angelico, M., additional, Burra, P., additional, Fagiuoli, S., additional, Toniutto, P., additional, Gasbarrini, A., additional, and Cillo, U., additional

Published
2012
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97. F-46 Graft survival is worse in HCV positive females transplanted with male donor grafts

Author

Belli, L., primary, Romagnoli, R., additional, Rossi, M., additional, Gerunda, G.E., additional, Pinna, A.D., additional, Agnes, S., additional, Spada, M., additional, Colledan, M., additional, Tisone, G., additional, De Carlis, L., additional, Baccarani, U., additional, Mazzaferro, V., additional, Ettorre, G.M., additional, Cillo, U., additional, Calise, F., additional, Cuomo, O., additional, Lupo, L., additional, Corradini, S. Ginanni, additional, Zamboni, F., additional, Marianelli, T., additional, Risaliti, A., additional, Patrono, D., additional, Li Petri, S., additional, Tagliabue, F., additional, Mangoni, J.M.E., additional, Antonelli, B., additional, Sposito, C., additional, Gringeri, E., additional, Rompianesi, G., additional, Sforza, D., additional, Cucchetti, A., additional, Miglioresi, L., additional, Donataccio, M., additional, Gelli, M., additional, Gavrila, C., additional, Nardi, A., additional, and Angelico, M., additional

Published
2012
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99. IL TRAPIANTO DI RENE E DI FEGATO NELL'ANZIANO.ESPERIENZE PERSONALI

Author

Alfani, D., Berloco, Pasquale Bartolomeo, Bruzzone, Paolo, Caricato, M., Casciaro, Giovanni Enrico, Cuomo, O., Iappelli, Massimo, Novelli, G., Poli, Luca, Pretagostini, Renzo, Rossi, Massimo, Venettoni, S., Urbano, D., and Cortesini, Raffaello

Published
1995

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