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We compared a conventional PET-CT scanner (Siemens Biograph TruePoint TrueV) with and without resolution modelling (RM) image reconstruction with a High Resolution Research Tomograph (HRRT) in order to assess the utility of conventional scanners for brain scanning. A modified Esser phantom and 6 neurofibromatosis 2 (NF2) patients with vestibular schwannomas (VS) were scanned using both scanners. The phantom was filled with fluorine-18 (40 MBq, 4:1 contrast ratio) and scanned for 60 minutes on separate occasions. Patients were injected with ~200 MBq of [18F]fluorodeoxyglucose (FDG) and [18F]fluorothymidine (FLT) on separate occasions and scanned for three consecutive 30 minute periods moving between scanners. The HRRT images, although noisier, resulted in higher contrast recovery for the smallest cylindrical inserts in comparison to TrueV with and without RM. With the TrueV, higher uptake values were observed in VS lesions with both FDG and FLT which is consistent with greater spill-in from the brain for FDG and bone marrow for FLT. RM decreased measured FDG uptake. For large homogenous lesions the conventional TrueV gives similar or better results compared to the HRRT. For smaller lesions, the HRRT has benefit, with RM on the TrueV unable to restore parity, and with the potential for image artefacts.

Swift J1753.5-0127 (J1753) is a candidate black hole low-mass X-ray binary (BH-LMXB) that was discovered in outburst in May 2005. It remained in outburst for $\sim12$ years, exhibiting a wide range of variability on various timescales, before entering quiescence after two short-lived, low-luminosity "mini-outbursts" in April 2017. The unusually long outburst duration in such a short-period ($P_{\rm orb}\approx3.24$ hrs) source, and complex variability observed during this outburst period, challenges the predictions of the widely accepted disc-instability model, which has been shown to broadly reproduce the behaviour of LMXB systems well. The long-term behaviour observed in J1753 is reminiscent of the Z Cam class of dwarf novae, whereby variable mass transfer from the companion star drives unusual outbursts, characterized by stalled decays and abrupt changes in luminosity. Using sophisticated modelling of the multi-wavelength light curves and spectra of J1753, during the $\sim12$ years the source was active, we investigate the hypothesis that periods of enhanced mass transfer from the companion star may have driven this unusually long outburst. Our modelling suggests that J1753 is in fact a BH-LMXB analogue to Z Cam systems, where the variable mass transfer from the companion star is driven by the changing irradiation properties of the system, affecting both the disc and companion star., Comment: 17 pages plus a 5 page appendix, 8 figures in main paper plus an additional figure in the appendix, accepted for publication in MNRAS

We report on simultaneous sub-second optical and X-ray timing observations of the low mass X-ray binary black hole candidate MAXI J1820+070. The bright 2018 outburst rise allowed simultaneous photometry in five optical bands ($ugriz_s$) with HiPERCAM/GTC (Optical) at frame rates over 100 Hz, together with NICER/ISS observations (X-rays). Intense (factor of two) red flaring activity in the optical is seen over a broad range of timescales down to $\sim$10 ms. Cross-correlating the bands reveals a prominent anti-correlation on timescales of $\sim$seconds, and a narrow sub-second correlation at a lag of $\approx$+165 ms (optical lagging X-rays). This lag increases with optical wavelength, and is approximately constant over Fourier frequencies of $\sim$0.3-10 Hz. These features are consistent with an origin in the inner accretion flow and jet base within $\sim$5000 Gravitational radii. An additional $\sim$+5 s lag feature may be ascribable to disc reprocessing. MAXI J1820+070 is the third black hole transient to display a clear $\sim$0.1s optical lag, which may be common feature in such objects. The sub-second lag $variation$ with wavelength is novel, and may allow constraints on internal shock jet stratification models., MNRAS Letters, In Press

Using the Very Long Baseline Array and the European Very Long Baseline Interferometry Network we have made a precise measurement of the radio parallax of the black hole X-ray binary MAXI\,J1820+070, providing a model-independent distance to the source. Our parallax measurement of ($0.348\pm0.033$) mas for MAXI J1820+070 translates to a distance of ($2.96\pm0.33$) kpc. This distance implies that the source reached ($15\pm3)\%$ of the Eddington luminosity at the peak of its outburst. Further, we use this distance to refine previous estimates of the jet inclination angle, jet velocity and the mass of the black hole in MAXI J1820+070 to be ($63\pm3)^{\circ}$, ($0.89\pm0.09)c$ and ($9.2\pm1.3) M_{\odot}$, respectively., Comment: 5 pages, 3 figures, Published in MNRAS

We present rapid, multiwavelength photometry of the low-mass X-ray binary Swift J1357.2-0933 during its 2017 outburst. Using several sets of quasi-simultaneous ULTRACAM/NTT (optical), NuSTAR (X-ray), XRT/Swift (X-ray), SALT (optical) and ATCA (radio) observations taken during outburst decline, we confirm the frequent optical dipping that has previously been noted both in outburst and in quiescence. We also find: 1) that the dip frequency decreases as the outburst decays, similar to what was seen in the previous outburst, 2) that the dips produce a shape similar to that in binary systems with partial disc occultations, 3) that the source becomes significantly bluer during these dips, indicating an unusual geometry compared to other LMXB dippers, and 4) that dip superposition analysis confirms the lack of an X-ray response to the optical dips. These very unusual properties appear to be unique to Swift J1357.2-0933, and are likely the result of a high binary inclination, as inferred from features such as its very low outburst X-ray luminosity. From this analysis as well as X-ray/optical timing correlations, we suggest a model with multi-component emission/absorption features with differing colours. This could include the possible presence of a sporadically occulted jet base and a recessed disc. This source still hosts many puzzling features, with consequences for the very faint X-ray transients population., Comment: 15 pages, 13 figures. Revised and resubmitted to MNRAS

We present multi-frequency monitoring observations of the black hole X-ray binary V404 Cygni throughout its June 2015 outburst. Our data set includes radio and mm/sub-mm photometry, taken with the Karl G. Jansky Very Large Array, Arc-Minute MicroKelvin Imager Large Array, Sub-millimeter Array, James Clerk Maxwell Telescope, and the Northern Extended Millimetre Array, combined with publicly available infrared, optical, UV, and X-ray measurements. With these data, we report detailed diagnostics of the spectral and variability properties of the jet emission observed during different stages of this outburst. These diagnostics show that emission from discrete jet ejecta dominated the jet emission during the brightest stages of the outburst. We find that the ejecta became fainter, slower, less frequent, and less energetic, before the emission transitioned (over 1--2 days) to being dominated by a compact jet, as the outburst decayed toward quiescence. While the broad-band spectrum of this compact jet showed very little evolution throughout the outburst decay (with the optically thick to thin synchrotron jet spectral break residing in the near-infrared/optical bands; $\sim2-5\times10^{14}$ Hz), the emission still remained intermittently variable at mm/sub-mm frequencies. Additionally, we present a comparison between the radio jet emission throughout the 2015 and previous 1989 outbursts, confirming that the radio emission in the 2015 outburst decayed significantly faster than in 1989. Lastly, we detail our sub-mm observations taken during the December 2015 mini-outburst of V404 Cygni, which demonstrate that, similar to the main outburst, the source was likely launching jet ejecta during this short period of renewed activity., Comment: 24 pages, 12 Figures, Accepted to MNRAS

We present a detailed analysis of the X-ray/IR fast variability of the Black-Hole Transient GX 339-4 during its low/hard state in August 2008. Thanks to simultaneous high time-resolution observations made with the VLT and RXTE, we performed the first characterisation of the sub-second variability in the near-infrared band - and of its correlation with the X-rays - for a low-mass X-ray binary, using both time and frequency-domain techniques. We found a power-law correlation between the X-ray and infrared fluxes when measured on timescales of 16 seconds, with a marginally variable slope, steeper than the one found on timescales of days at similar flux levels. We suggest the variable slope - if confirmed - could be due to the infrared flux being a non-constant combination of both optically thin and optically thick synchrotron emission from the jet, as a result of a variable self-absorption break. From cross spectral analysis we found an approximately constant infrared time lag of $\approx$ 0.1s, and a very high coherence of $\approx$ 90 per cent on timescales of tens of seconds, slowly decreasing toward higher frequencies. Finally, we report on the first detection of a linear rms-flux relation in the emission from a low-mass X-ray binary jet, on timescales where little correlation is found between the X-rays and the jet emission itself. This suggests that either the inflow variations and jet IR emission are coupled by a non-linear or time-variable transform, or that the IR rms-flux relation is not transferred from the inflow to the jet, but is an intrinsic property of emission processes in the jet., 11 pages, 8 figures. Accepted for publication in MNRAS

To confirm the nature of the donor star in the ultra-compact X-ray binary candidate 47 Tuc X9, we obtained optical spectra (3,000$-$10,000 {\AA}) with the Hubble Space Telescope / Space Telescope Imaging Spectrograph. We find no strong emission or absorption features in the spectrum of X9. In particular, we place $3\sigma$ upper limits on the H$\alpha$ and HeII $\lambda 4686$ emission line equivalent widths $-$EW$_{\mathrm{H\alpha}} \lesssim 14$ {\AA} and $-$EW$_{\mathrm{HeII}} \lesssim 9$ {\AA}, respectively. This is much lower than seen for typical X-ray binaries at a similar X-ray luminosity (which, for $L_{\mathrm{2-10 keV}} \approx 10^{33}-10^{34}$ erg s$^{-1}$ is typically $-$EW$_{\mathrm{H\alpha}} \sim 50$ {\AA}). This supports our previous suggestion (by Bahramian et al.) of an H-poor donor in X9. We perform timing analysis on archival far-ultraviolet, $V$ and $I$-band data to search for periodicities. In the optical bands we recover the seven-day superorbital period initially discovered in X-rays, but we do not recover the orbital period. In the far-ultraviolet we find evidence for a 27.2 min period (shorter than the 28.2 min period seen in X-rays). We find that either a neutron star or black hole could explain the observed properties of X9. We also perform binary evolution calculations, showing that the formation of an initial black hole / He-star binary early in the life of a globular cluster could evolve into a present-day system such as X9 (should the compact object in this system indeed be a black hole) via mass-transfer driven by gravitational wave radiation., Comment: 20 pages, 12 figures. Accepted for publication in MNRAS

IGR J17062-6143 is an ultra-compact X-ray binary (UCXB) with an orbital period of 37.96 min. It harbours a millisecond X-ray pulsar that is spinning at 163 Hz and and has continuously been accreting from its companion star since 2006. Determining the composition of the accreted matter in UCXBs is of high interest for studies of binary evolution and thermonuclear burning on the surface of neutron stars. Here, we present a multi-wavelength study of IGR J17062-6143 aimed to determine the detailed properties of its accretion disc and companion star. The multi-epoch photometric UV to near-infrared spectral energy distribution (SED) is consistent with an accretion disc $F_{\nu}\propto\nu^{1/3}$. The SED modelling of the accretion disc allowed us to estimate an outer disc radius of $R_{out}=2.2^{+0.9}_{-0.4} \times 10^{10}$ cm and a mass-transfer rate of $\dot{m}=1.8^{+1.8}_{-0.5}\times10^{-10}$ M$_{\odot}$ yr$^{-1}$. Comparing this with the estimated mass-accretion rate inferred from its X-ray emission suggests that $\gtrsim$90% of the transferred mass is lost from the system. Moreover, our SED modelling shows that the thermal emission component seen in the X-ray spectrum is highly unlikely from the accretion disc and must therefore represent emission from the surface of the neutron star. Our low-resolution optical spectrum revealed a blue continuum and no emission lines, i.e. lacking H and He features. Based on the current data we cannot conclusively identify the nature of the companion star, but we make recommendations for future study that can distinguish between the different possible evolution histories of this X-ray binary. Finally, we demonstrate how multiwavelength observations can be effectively used to find more UCXBs among the LMXBs., Comment: 10 pages, 8 figures, accepted in MNRAS

We conduct a detailed case-study of the interstellar shell near the high-mass X-ray binary, Cygnus X-1. We present new WIYN optical spectroscopic and Chandra X-ray observations of this region, which we compare with detailed MAPPINGS III shock models, to investigate the outflow powering the shell. Our analysis places improved, physically motivated constraints on the nature of the shockwave and the interstellar medium (ISM) it is plowing through. We find that the shock is traveling at less than a few hundred km/s through a low-density ISM (< 5 cm^-3). We calculate a robust, 3 sigma upper limit to the total, time-averaged power needed to drive the shockwave and inflate the bubble, < 2 x 10^38 erg/s. We then review possible origins of the shockwave. We find that a supernova origin to the shockwave is unlikely and that the black hole jet and/or O-star wind can both be central drivers of the shockwave. We conclude that the source of the Cygnus X-1 shockwave is far from solved., 16 pages, 8 figures, accepted for publication in MNRAS

We present optical and near-IR linear polarimetry of V404Cyg during its 2015 outburst and in quiescence. We obtained time-resolvedr΄-band polarimetry when the source was in outburst, near-IR polarimetry when the source was near quiescence and multiple waveband optical polarimetry later in quiescence. The optical-to-near-IR linear polarization spectrum can be described by interstellar dust and an intrinsic variable component. The intrinsic optical polarization, detected during the rise of one of the brightest flares of the outburst, is variable, peaking at 4.5percent and decaying to 3.5percent. We present several arguments that favour a synchrotron jet origin to this variable polarization, with the optical emission originating close to the jet base. The polarization flare occurs during the initial rise of a major radio flare event that peaks later, and is consistent with a classically evolving synchrotron flare from an ejection event. We conclude that the optical polarization flare represents a jet launching event, the birth of a major ejection. For this event, we measure a rather stable polarization position angle of −9° E of N, implying that the magnetic field near the base of the jet is approximately perpendicular to the jet axis. This may be due to the compression of magnetic field lines in shocks in the accelerated plasma, resulting in a partially ordered transverse field that have now been seen during the 2015 outburst. We also find that this ejection occurred at a similar stage in the repetitive cycles of flares.

We present results taken from a study aiming at detecting the emission from relativistic particles jets in neutron star-low mass X-ray binaries using optical polarimetric observations. First, we focus on a polarimetric study performed on the persistent LMXB 4U 0614+091. Once corrected for interstellar effects, we measured an intrinsic linear polarization in the r-band of ~3% at a 3σ confidence level. This is in-line with the observation of an infrared excess in the spectral energy distribution (SED) of the source, reported in a previous work, which the authors linked to the optically thin synchrotron emission of a jet. We then present a study performed on the transitional millisecond pulsar PSR J1023+0038 during quiescence. We measured a linear polarization of 1.09 ± 0.27% and 0.90 ± 0.17% in the V and R bands, respectively. The phase-resolved polarimetric curve of the source in the R-band reveals a hint of a sinusoidal modulation at the source orbital period. The NIR -optical SED of the system did not suggest the presence of a jet. We conclude that the optical linear polarization observed for PSR J1023+0038 is possibly due to Thomson scattering with electrons in the disc, as also suggested by the hint of the modulation of the R-band linear polarization at the system orbital period.

Transient small-scale structures were identified in the wake of blobs moving poloidally through the scrape-off layer of high-powered H-mode plasmas in NSTX, using the gas puff imaging (GPI) diagnostic. These blob wakes had a poloidal wavelength in the range of λpol = 3.5 ± 0.7 cm, which is significantly smaller than the average blob scale of Lpol ∼ 12 cm, and the wakes had a poloidal velocity of Vpol = 1.5 ± 1.0 km/s in the electron diamagnetic direction, which is opposite to the blob poloidal velocity in these shots. These wakes were radially localized 0–4 cm outside the separatrix and occurred within ∼50 μs after the passage of a blob through the GPI field of view. The clearest wakes were seen when the GPI viewing angle was well aligned with the local B field line, as expected for such small-scale structures given the diagnostic geometry. A plausible theoretical interpretation of the wakes is discussed: the observed wakes share some features of drift waves and/or drift-Alfven waves which could be excited by the blobs.

The 2D scrape-off-layer turbulence code (SOLT) is extended to include neutral-plasma interactions. A Boltzmann equation is derived for the evolution of the bi-normally averaged neutral distribution function, G(x,vx,t), in the radial dimension, and this evolution is included in the new scrape-off-layer turbulence code (nSOLT). Neutral-plasma interactions are mediated by charge-exchange (CX) and ionization rates based on poloidally averaged plasma density and temperature. Good agreement is obtained between asymptotically stationary neutral density profiles from nSOLT simulations and those previously obtained from the Monte Carlo neutral transport code DEGAS 2, for time-averaged NSTX H-mode plasma profiles. The sensitivity of the nSOLT neutral profiles to atomic physics parameters, with and without CX physics, is included in the comparison. In addition, nSOLT simulations that evolve the plasma in 1D, using radial diffusion as a proxy for turbulent (blob) transport, illustrate the convergence to a self-consistent neutral-plasma equilibrium sustained by a neutral source at the far-scrape-off-layer boundary and plasma heating in the core; equilibria consistent with typical NSTX Ohmic L-mode plasmas are described.The 2D scrape-off-layer turbulence code (SOLT) is extended to include neutral-plasma interactions. A Boltzmann equation is derived for the evolution of the bi-normally averaged neutral distribution function, G(x,vx,t), in the radial dimension, and this evolution is included in the new scrape-off-layer turbulence code (nSOLT). Neutral-plasma interactions are mediated by charge-exchange (CX) and ionization rates based on poloidally averaged plasma density and temperature. Good agreement is obtained between asymptotically stationary neutral density profiles from nSOLT simulations and those previously obtained from the Monte Carlo neutral transport code DEGAS 2, for time-averaged NSTX H-mode plasma profiles. The sensitivity of the nSOLT neutral profiles to atomic physics parameters, with and without CX physics, is included in the comparison. In addition, nSOLT simulations that evolve the plasma in 1D, using radial diffusion as a proxy for turbulent (blob) transport, illustrate the convergence to a self-consis...

[Abridged] We report on deep, coordinated radio and X-ray observations of the black hole X-ray binary XTE J1118+480 in quiescence. The source was observed with the Karl G. Jansky Very Large Array for a total of 17.5 hrs at 5.3 GHz, yielding a 4.8 \pm 1.4 microJy radio source at a position consistent with the binary system. At a distance of 1.7 kpc, this corresponds to an integrated radio luminosity between 4-8E+25 erg/s, depending on the spectral index. This is the lowest radio luminosity measured for any accreting black hole to date. Simultaneous observations with the Chandra X-ray Telescope detected XTE J1118+480 at 1.2E-14 erg/s/cm^2 (1-10 keV), corresponding to an Eddington ratio of ~4E-9 for a 7.5 solar mass black hole. Combining these new measurements with data from the 2005 and 2000 outbursts available in the literature, we find evidence for a relationship of the form ellr=alpha+beta*ellx (where ell denotes logarithmic luminosities), with beta=0.72\pm0.09. XTE J1118+480 is thus the third system, together with GX339-4 and V404 Cyg, for which a tight, non-linear radio/X-ray correlation has been reported over more than 5 dex in ellx. We then perform a clustering and linear regression analysis on what is arguably the most up-to-date collection of coordinated radio and X-ray luminosity measurements from quiescent and hard state black hole X-ray binaries, including 24 systems. At variance with previous results, a two-cluster description is statistically preferred only for random errors, Accepted by MNRAS, 13 pages

Sagittal otoliths were used to age the samples of Tilapia mariae collected from a coastal river and an impoundment. Validation of sagittae checks was achieved using both quantitative marginal increment analysis and by tetracycline marking of the otoliths of fish kept in tanks and in a farm dam. The annulus pattern on the otoliths was generally clear and their formation appeared to be temperature related and largely completed in the Austral spring around September and October. Male T. mariae grow faster and larger than females and the maximum ages of fish from the coastal river and impoundment was 9+ and 4+ years, respectively. Past fish surveys and the absence of older age classes in the impoundment population would suggest that this population was only very recently established.

We present timing and spectral analysis of a sample of seven hard X-ray selected Cataclysmic Variable candidates based on simultaneous X-ray and optical observations collected with XMM-Newton , complemented with Swift/BAT and INTEGRAL/IBIS hard X-ray data and ground-based optical photometry. For six sources, X-ray pulsations are detected for the first time in the range $\rm \sim296-6098\,s$, identifying them as members of the magnetic class. Swift J0927.7-6945, Swift J0958.0-4208, Swift J1701.3-4304, Swift J2113.5+5422, and possibly PBC J0801.2-4625, are Intermediate Polars (IPs), while Swift J0706.8+0325 is a short (1.7 h) orbital period Polar, the 11$^{\rm th}$ hard X-ray selected identified so far. X-ray orbital modulation is also observed in Swift J0927.7-6945 (5.2 h) and Swift J2113.5+5422 (4.1 h). Swift J1701.3-4304 is discovered as the longest orbital period (12.8 h) deep eclipsing IP. The spectra of the magnetic systems reveal optically thin multi-temperature emission between 0.2 and 60 keV. Energy dependent spin pulses and the orbital modulation in Swift J0927.7-6945 and Swift J2113.5+5422 are due to intervening local high density absorbing material ($\rm N_H\sim10^{22-23}\,cm^{-2}$). In Swift J0958.0-4208 and Swift J1701.3-4304, a soft X-ray blackbody (kT$\sim$50 and $\sim$80 eV) is detected, adding them to the growing group of "soft" IPs. White dwarf masses are determined in the range $\rm \sim0.58-1.18\,M_{\odot}$, indicating massive accreting primaries in five of them. Most sources accrete at rates lower than the expected secular value for their orbital period. Formerly proposed as a long-period (9.4 h) novalike CV, Swift J0746.3-1608 shows peculiar spectrum and light curves suggesting either an atypical low-luminosity CV or a low mass X-ray binary., Comment: 23 pages, 7 tables, and 6 Figures. Accepted for publications on MNRAS on June 13th, 2017

In outburst, neutron star X-ray binaries produce less powerful jets than black holes at a given X-ray luminosity. This has made them more difficult to study as they fade towards quiescence. To explore whether neutron stars power jets at low accretion rates ($L_{\rm X} \lesssim 10^{36}$ erg s$^{-1}$), we investigate the radio and X-ray properties of three accreting millisecond X-ray pulsars (IGR J17511-3057, SAX J1808.4-3658 and IGR J00291+5934) during their outbursts in 2015, and of the non-pulsing neutron star Cen X-4 in quiescence (2015) and in outburst (1979). We did not detect the radio counterpart of IGR J17511-3057 in outburst or of Cen X-4 in quiescence, but did detect IGR J00291+5934 and SAX J1808.4-3658, showing that at least some neutron stars launch jets at low accretion rates. While the radio and X-ray emission in IGR J00291+5934 seem to be tightly correlated, the relationship in SAX J1808.4-3658 is more complicated. We find that SAX J1808.4-3658 produces jets during the reflaring tail, and we explore a toy model to ascertain whether the radio emission could be attributed to the onset of a strong propeller. The lack of a universal radio/X-ray correlation, with different behaviours in different neutron star systems (with various radio/X-ray correlations; some being radio faint and others not), points at distinct disk-jet interactions in individual sources, while always being fainter in the radio band than black holes at the same X-ray luminosity.

In veterinary oncologic specimens, histopathology is the gold standard for determining adequacy of excision. Despite limitations of this technique, the pathologist's interpretation of margin status significantly impacts patient management, including indications for adjuvant therapy. This article aims to summarize peer-reviewed literature as it relates to histologic margin evaluation in veterinary cancer patients. The value of histologic tumour-free margins and technical factors influencing histopathologic margin outcomes are also discussed. We review alternative strategies for determining excisional status, and discuss how an evolving understanding of tumour biology might inform clinical and research perspectives on surgical margins. In doing so, we aim to provide context and a stimulus for future investigations into this important yet incompletely understood topic.

We present the results of our intensive radio observing campaign of the dwarf nova SS Cyg during its 2010 April outburst. We argue that the observed radio emission was produced by synchrotron emission from a transient radio jet. Comparing the radio light curves from previous and subsequent outbursts of this system (including high-resolution observations from outbursts in 2011 and 2012) shows that the typical long and short outbursts of this system exhibit reproducible radio outbursts that do not vary significantly between outbursts, which is consistent with the similarity of the observed optical, ultraviolet and X-ray light curves. Contemporaneous optical and X-ray observations show that the radio emission appears to have been triggered at the same time as the initial X-ray flare, which occurs as disk material first reaches the boundary layer. This raises the possibility that the boundary region may be involved in jet production in accreting white dwarf systems. Our high spatial resolution monitoring shows that the compact jet remained active throughout the outburst with no radio quenching., 15 pages, 9 figures, Accepted for publication in MNRAS

Sheared flows perpendicular to the magnetic field can be driven by the Reynolds stress or ion pressure gradient effects and can potentially influence the stability and turbulent saturation level of edge plasma modes. On the other hand, such flows are subject to the transverse Kelvin–Helmholtz (KH) instability. Here, the linear theory of KH instabilities is first addressed with an analytic model in the asymptotic limit of long wavelengths compared with the flow scale length. The analytic model treats sheared $\boldsymbol{E}\times \boldsymbol{B}$ flows, ion diamagnetism (including gyro-viscous terms), density gradients and parallel currents in a slab geometry, enabling a unified summary that encompasses and extends previous results. In particular, while ion diamagnetism, density gradients and parallel currents each individually reduce KH growth rates, the combined effect of density and ion pressure gradients is more complicated and partially counteracting. Secondly, the important role of realistic toroidal geometry is explored numerically using an invariant scaling analysis together with the 2DX eigenvalue code to examine KH modes in both closed and open field line regions. For a typical spherical torus magnetic geometry, it is found that KH modes are more unstable at, and just outside of, the separatrix as a result of the distribution of magnetic shear. Finally implications for reduced edge turbulence modelling codes are discussed.

To assess whether the introduction of a management of raised glucose clinical decision tool could improve assessment of patients with hyperglycaemia by non-specialist physicians, leading to early discharge and improved quality of inpatient care.

The microquasar GX 339-4 experienced an outburst in 2010. We focus on observations that are quasi-simultaneous with those made by INTEGRAL and RXTE in March–April 2010 with radio, NIR, optical and UV data. X-ray transients are extreme systems, often harboring a black hole, known to emit throughout the whole electromagnetic spectrum in outburst. We studied the source evolution and correlated changes in all wavelengths. The bolometric flux increased from 0.8 to 2.9 × 10−8 erg cm−2 s−1 while the relative contribution of the hot medium decreased. The radio, NIR and optical emission from jets was detected and observed to fade as the source softened; reprocessing in the disc was strong at the end.

Oreochromis mossambicus (Peters 1852) are native to the eastward flowing rivers of central and southern Africa but from the early 1930s they have been widely distributed around the world for aquaculture and for biological control of weeds and insects. While O. mossambicus are now not commonly used as an aquaculture species, the biological traits that made them a popular culture species including tolerance to wide ranging ecological conditions, generalist dietary requirements and rapid reproduction with maternal care have also made them a ‘model’ invader. Self-sustaining populations now exist in almost every region to which they have been imported. In Australia, since their introduction in the 1970s, O. mossambicus have become established in catchments along the east and west coasts and have the potential to colonise other adjacent drainages. It is thought that intentional translocations are likely to be the most significant factor in their spread in Australia. The ecological and physical tolerances and preferences, reproductive behaviour, hybridization and the high degree of plasticity in the life history traits of O. mossambicus are reviewed. Impacts of O. mossambicus on natural ecosystems including competitive displacement of native species, habitat alteration, predation and as a vector in the spread of diseases are discussed. Potential methods for eradicating or controlling invasive populations of O. mossambicus including physical removal, piscicides, screens, environmental management and genetic technologies are outlined.

A new dual temporal resolution-based, high spatial resolution, pharmacokinetic parametric mapping method is described--improved coverage and spatial resolution using dual injection dynamic contrast-enhanced (ICE-DICE) MRI. In a dual-bolus dynamic contrast-enhanced-MRI acquisition protocol, a high temporal resolution prebolus is followed by a high spatial resolution main bolus to allow high spatial resolution parametric mapping for cerebral tumors. The measured plasma concentration curves from the dual-bolus data were used to reconstruct a high temporal resolution arterial input function. The new method reduces errors resulting from uncertainty in the temporal alignment of the arterial input function, tissue response function, and sampling grid. The technique provides high spatial resolution 3D pharmacokinetic maps (voxel size 1.0 x 1.0 x 2.0 mm(3)) with whole brain coverage and greater parameter accuracy than that was possible with the conventional single temporal resolution methods. High spatial resolution imaging of brain lesions is highly desirable for small lesions and to support investigation of heterogeneity within pathological tissue and peripheral invasion at the interface between diseased and normal brain. The new method has the potential to be used to improve dynamic contrast-enhanced-MRI techniques in general.

We present optical monitoring of the black hole candidate XTE J1752-223 during its 2009 - 2010 outburst and decay to quiescence. The optical light curve can be described by an exponential decay followed by a plateau, then a more rapid fade towards quiescence. The plateau appears to be due to an extra component of optical emission that brightens and then fades over ~ 40 days. We show evidence for the origin of this optical 'flare' to be the synchrotron jet during the decaying hard state, and we identify and isolate both disc and jet components in the spectral energy distributions. The optical flare has the same morphology and amplitude as a contemporaneous X-ray rebrightening. This suggests a common origin, but no firm conclusions can be made favouring or disfavouring the jet producing the X-ray flare. The quiescent optical magnitudes are B >= 20.6, V >= 21.1, R >= 19.5, i' >= 19.2. From the optical outburst amplitude we estimate a likely orbital period of < 22 h. We also present near-infrared (NIR) photometry and polarimetry and rare mid-infrared imaging (8 - 12 microns) when the source is nearing quiescence. The fading jet component, and possibly the companion star may contribute to the NIR flux. We derive deep mid-IR flux upper limits and NIR linear polarization upper limits. With the inclusion of radio data, we measure an almost flat jet spectral index between radio and optical; F_nu ~ nu^(~ +0.05). The data favour the jet break to optically thin emission to reside in the infrared, but may shift to frequencies as high as the optical or UV during the peak of the flare.

The convective radial transport effects of SOL turbulence have been estimated using recent turbulence data from the gas puff imaging (GPI) camera diagnostic on Alcator C-Mod. The average radial turbulence speed within the region 1-2 cm outside the separatrix near the outer was calculated by a 2-0 cross-correlation technique to be V-t similar to 0.2-0.3 km/s. Assuming this to be the local convective plasma velocity, the density SOL width lambda(n) was evaluated using a simple convective model to be lambda(n) similar to 4-7 cm, which is similar to 2-3 times higher than that measured using a Langmuir probe. This convective velocity was also similar to 2-3 times lower than the velocities estimated from analytic blob models, but showed a similar scaling with plasma current at constant q(95). The measured blob speeds were lower than both the convective speeds and the analytic blob model speeds.

The two-dimensional fluid turbulence code SOLT is employed to study the role of midplane turbulence on the scrape-off-layer (SOL) heat flux width of tokamak plasmas. The physics simulated includes curvature-driven-interchange modes, sheath losses, and perpendicular turbulent diffusive and convective (blob) transport. Midplane SOL profiles of density, temperature and parallel heat flux are obtained from the simulation and compared with experimental results from the National Spherical Torus Experiment (NSTX) to study the scaling of the heat flux width with power and plasma current. It is concluded that midplane turbulence is the main contributor to the SOL width for the low power ELM-free H-mode discharges studied, while additional physics is required to explain the plasma current scaling of the SOL width observed experimentally in higher power discharges. Additional simulations predict a transition to a convectively-dominated SOL at critical values of power and connection length.

We report on the analysis of 34 years of photometric observations of the pulsating helium atmosphere white dwarf GD358. The complete data set includes archival data from 1982-2006, and 1195.2 hours of new observations from 2007- 2016. From this data set, we extract 15 frequencies representing g-mode pulsation modes, adding 4 modes to the 11 modes known previously. We present evidence that these 15 modes are ell = 1 modes, 13 of which belong to a consecutive sequence in radial overtone k. We perform a detailed asteroseismic analysis using models that include parameterized, complex carbon and oxygen core composition profiles to fit the periods. Recent spectroscopic analyses place GD358 near the red edge of the DBV instability strip, at 24,000 plus or minus 500 K and a log g of 7.8 plus or minus 0.08 dex. The surface gravity translates to a mass range of 0.455 to 0.540 solar masses. Our best fit model has a temperature of 23,650 K and a mass of 0.5706 solar masses. That is slightly more massive than suggested by most the recent spectroscopy. We find a pure helium layer mass of 10^-5.50, consistent with the result of previous studies and the outward diffusion of helium over time., Comment: 94 pages, 14 figures, 7 tables, Accepted for publication in the ApJ

Gas puff imaging (GPI) observations made in NSTX (Zweben et al 2017 Phys. Plasmas 24 102509) have revealed two‐point spatial correlations of edge and scrape-off layer (SOL) turbulence in the plane perpendicular to the magnetic field. A common feature is the occurrence of dipole-like patterns with significant regions of negative correlation. In this paper, we explore the possibility that these dipole patterns may be due to blob-hole pairs. Statistical methods are applied to determine the two-point spatial correlation that results from a model of blob-hole pair formation. It is shown that the model produces dipole correlation patterns that are qualitatively similar to the GPI data in several respects. Effects of the reference location (confined surfaces or SOL), a superimposed random background, hole velocity and lifetime, and background sheared flows are explored and discussed with respect to experimental observations. Additional analysis of the experimental GPI dataset is performed to further test this blob-hole correlation model. A time delay two‐point spatial correlation study did not reveal inward propagation of the negative correlation structures that were postulated to correspond to holes in the data nor did it suggest that the negative correlation structures are due to neutral shadowing. However, tracking of the highest and lowest values (extrema) of the normalized GPI fluctuations shows strong evidence for mean inward propagation of minima and outward propagation of maxima, in qualitative agreement with theoretical expectations. Other properties of the experimentally observed extrema are discussed.

The oxygen-isotope compositions (obtained by laser fluorination) of hand-picked separates of isolated forsterite, isolated olivine and chondrules from the Tagish Lake carbonaceous chondrite describe a line (δ17O = 0.95 * δ18O − 3.24; R2 = 0.99) similar to the trend known for chondrules from other carbonaceous chondrites. The isolated forsterite grains (Fo99.6–99.8; δ18O = −7.2‰ to −5.5‰; δ17O = −9.6‰ to −8.2‰) are more 16O-rich than the isolated olivine grains (Fo39.6–86.8; δ18O = 3.1‰ to 5.1‰; δ17O = −0.3‰ to 2.2‰), and have chemical and isotopic characteristics typical of refractory forsterite. Chondrules contain olivine (Fo97.2–99.8) with oxygen-isotope compositions (δ18O = −5.2‰ to 5.9‰; δ17O = −8.1‰ to 1.2‰) that overlap those of isolated forsterite and isolated olivine. An inverse relationship exists between the Δ17O values and Fo contents of Tagish Lake isolated forsterite and chondrules; the chondrules likely underwent greater exchange with 16O-poor nebular gases than the forsterite. The oxygen-isotope compositions of the isolated olivine grains describe a trend with a steeper slope (1.1 ± 0.1, R2 = 0.94) than the carbonaceous chondrite anhydrous mineral line (CCAMslope = 0.95). The isolated olivine may have crystallized from an evolving melt that exchanged with 16O-poor gases of somewhat different composition than those which affected the chondrules and isolated forsterite. The primordial components of the Tagish Lake meteorite formed under conditions similar to other carbonaceous chondrite meteorite groups, especially CMs. Its alteration history has its closest affinities to CI carbonaceous chondrites.

[Profound alterations in metabolism occur within the first few minutes of myocardial ischaemia which may induce or modulate myocardial electrophysiological abnormalities and arrhythmogenesis, Fatty acid oxidation is inhibited with accumulation of long-chain acyl CoA esters and glycolysis is stimulated but later inhibited. This may be worsened by a peripheral sympathetic response. In particular regional variations in glycolytic ATP productions which can modulate "slow channel" ion flux and hence slow conducting "slow response" potential activity, could influence patterns of slow conduction in ischaemic myocardium of importance in generating early re-entrant arrhythmias. This possibility has been examined in open chest anaesthetised dogs following experimental coronary occlusion by detailed computer aided analysis and construction of three dimensional maps of regional metabolism, blood flow and epicardial activation patterns at the time of early ventricular arrhythmias. Activation patterns were obtained using an electronic multiplexing system, flow using tracer microspheres and metabolic changes by analysis of multiple tissue samples for lactate and indices of glycolytic activity after rapid excision and freezing of the heart. Marked spacial inhomogeneities in flow, lactate and glycolytic activity were associated with delayed and fragmented activation in the central ischaemic region. Within the border region of flow, however, glycolytic activity was enhanced and conduction generally little impaired. It is suggested that transient changes in the homogeneity of myocardial metabolism and flow are critical in determining patterns of conduction and hence arrhythmogenesis. This may provide a basis for understanding anti-arrhythmic effects of metabolic interventions.

We present phase resolved optical spectroscopy and photometry of V4580 Sagittarii, the optical counterpart to the accretion powered millisecond pulsar SAX J1808.4-3658, obtained during the 2008 September/October outburst. Doppler tomography of the N III 4640.64 Bowen blend emission line reveals a focused spot of emission at a location consistent with the secondary star. The velocity of this emission occurs at 324 +/- 15 km/s; applying a "K-correction", we find the velocity of the secondary star projected onto the line of sight to be 370 +/- 40 km/s. Based on existing pulse timing measurements, this constrains the mass ratio of the system to be 0.044^{+0.005}_{-0.004}, and the mass function for the pulsar to be 0.44^{+0.16}_{-0.13} Msun. Combining this mass function with various inclination estimates from other authors, we find no evidence to suggest that the neutron star in SAX J1808.4-3658 is more massive than the canonical value of 1.4 Msun. Our optical light curves exhibit a possible superhump modulation, expected for a system with such a low mass ratio. The equivalent width of the Ca II H and K interstellar absorption lines suggest that the distance to the source is ~2.5 kpc. This is consistent with previous distance estimates based on type-I X-ray bursts which assume cosmic abundances of hydrogen, but lower than more recent estimates which assume helium-rich bursts., 12 pages, 10 figures; Accepted for publication in MNRAS

A Resource Allocation System for Agricultural Research (RASAR) was developed [40] as a framework (a) to provide adequate criteria for resource allocation decisions, !(b) to guide the assessment of research, and (c) to effectively use mathematical models to generate decision-aiding information. RASAR was conceptualized as an iterative system for selecting a portfolio of research projects such that the research outputs would provide society with the potential power to change the agricultural system in ways that are expected to bring about the greatest improvement in social welfare. The ultimate goal of agricultural research was tentatively identified as having nine dimensions in three broad categories: Consumption category–(1) Quantity, (2) Quality, (3) Availability; Security category–{4) Human Safety, (5) Economic Defense, (6) Food Sources Security, (7) Conservation; Equity category–(8) Distribution, (9) Individual Rights. Subsystems within RASAR for generating socio-economic data relating to these dimensions were specified and demonstrated with case study research projects. A mathematical programming model for assimilating the complexity of criteria and data into a form which is readily usable for decision making was developed and evaluated. Un systeme ď allocation des fonds pour les recherches agronomiques (SAFRA) a ete developpe [40] comme un cadre de travail (a) pour fournir les criteres necessaircs pour decisions en matiere ď allocation de fonds, (b) pour guider la repartion des recherches, el (c) pour employes efficacement des modeles mathematiques pour engendrer des informations pour aider les decisions. On a concu le SAFRA comme systeme iteratif pouvant etre utilise pour la selection ď un portejeuille de projets de recherche tel que le rendement pourraient fournir avec une force potentielle a la societe le possibilitye de changer le systeme agricole dans le sens qui permettrait la plus grande amelioration du bien-etre social. Le but final de la recherche agronomique a ete defini experimentalement comme ayant nef dimensions dans trois grandes categories: Categorie de la consommation–(1) qitantile, (2) qualitye, (3) disponibilite; Categorie de la securite–(4) securite de ľ homme, (5) defense economique, (6) securite des ressources alimentaires, (7) conservation; Categorie ďequite–(8) distribution, (9) droits de ľ individu. Pour fournir les donnees socio-economiques sc rapportant a ces dimensions, des sous-systemes out eteetablis an sein du SAFRA et ils out ete demontre sur la base ď une etude de projets de recherche. On a egalement developpe et evalue un modele mathematique de programmation pour assimiler la complexite des criteres et des donnees sous une forme qui pent etre facilement utilisee pour la prise de decisions.

Ignition tests were carried out on three different pyrotechnics using laser energy from the multimode output from an Ar-Ion laser (av) at 500 nm and a near-IR diode laser pigtailed to a fibre optic cable and operating at 808 nm. The pyrotechnics investigated were: G20 black powder, SR44 and SR371C. The confined ignition tests were conducted in a specially designed ignition chamber. Pyrotechnics were ignited by a free space beam entering the chamber through an industrial sapphire window in the case of the Ar-ion laser. For the NIR diode laser, fibre was ducted through a block into direct contact with the pyrotechnic. The Ar-Ion laser was chosen as this was found to ignite all three pyrotechnics in the unconfined condition. It also allowed for a direct comparison of confined/unconfined results to be made. The threshold laser flux densities to initiate reproducible ignitions at this wavelength were found to be between ∼12.7 and ∼0.16 kW cm−2. Plotted on the ignition maps are the laser flux densities versus the start of ignition times for the three confined pyrotechnics. It was found from these maps that the times for confined ignition were substantially lower than those obtained for unconfined ignition under similar experimental conditions. For the NIR diode laser flux densities varied between ∼6.8 and ∼0.2 kW cm−2. The minimum ignition times for the NIR diode laser for SR371C (∼11.2 ms) and G20 (∼17.1 ms) were faster than those achieved by the use of the Ar-ion laser. However, the minimum ignition time was shorter (∼11.7 ms) with the Ar-ion laser for SR44.

Near-infrared (NIR) and optical polarimetric observations of a selection of X-ray binaries are presented. The targets were observed using the Very Large Telescope and the United Kingdom Infrared Telescope. We detect a significant level (3 sigma) of linear polarisation in four sources. The polarisation is found to be intrinsic (at the > 3 sigma level) in two sources; GRO J1655-40 (~ 4-7% in H and Ks-bands during an outburst) and Sco X-1 (~ 0.1-0.9% in H and K), which is stronger at lower frequencies. This is likely to be the signature of optically thin synchrotron emission from the collimated jets in these systems, whose presence indicates a partially-ordered magnetic field is present at the inner regions of the jets. In Sco X-1 the intrinsic polarisation is variable (and sometimes absent) in the H and K-bands. In the J-band (i.e. at higher frequencies) the polarisation is not significantly variable and is consistent with an interstellar origin. The optical light from GX 339-4 is also polarised, but at a level and position angle consistent with scattering by interstellar dust. The other polarised source is SS 433, which has a low level (0.5-0.8%) of J-band polarisation, likely due to local scattering. The NIR counterparts of GRO J0422+32, XTE J1118+480, 4U 0614+09 and Aql X-1 (which were all in or near quiescence) have a linear polarisation level of < 16% (3 sigma upper limit, some are < 6%). We discuss how such observations may be used to constrain the ordering of the magnetic field close to the base of the jet in such systems., Accepted to be published in MNRAS; 13 pages, 6 figures

We present analysis of fast variability of Very Large Telescope/ISAAC (infra-red), \textit{XMM-Newton}/OM (optical) and EPIC-pn (X-ray), and RXTE/PCA (X-ray) observations of the black hole X-ray binary GX 339-4 in a rising hard state of its outburst in 2010. We report the first detection of a Quasi Periodic Oscillation (QPO) in the infra-red band (IR) of a black hole X-ray binary. The QPO is detected at 0.08 Hz in the IR as well as two optical bands (U and V). Interestingly, these QPOs are at half the X-ray QPO frequency at 0.16 Hz, which is classified as the type-C QPO; a weak sub-harmonic close to the IR and optical QPO frequency is also detected in X-rays. The broad band sub-second time scale variability is strongly correlated in IR/X-ray bands, with X-rays leading the IR by over 100 ms. This short time delay, shape of the cross correlation function and spectral energy distribution strongly indicate that this broad band variable IR emission is the synchrotron emission from the jet. A jet origin for the IR QPO is strongly favoured, but cannot be definitively established with the current data. The spectral energy distribution indicates a thermal disc origin for the bulk of the optical emission, but the origin of the optical QPO is unclear. We discuss our findings in the context of the existing models proposed to explain the origin of variability., Comment: 9 pages, 3 figures, Accepted for publication in the MNRAS

We present observations of rapid (sub-second) optical flux variability in V404 Cyg during its 2015 June outburst. Simultaneous three-band observations with the ULTRACAM fast imager on four nights show steep power spectra dominated by slow variations on ~100-1000s timescales. Near the peak of the outburst on June 26, a dramatic change occurs and additional, persistent sub-second optical flaring appears close in time to giant radio and X-ray flaring. The flares reach peak optical luminosities of ~few x 10^{36} erg/s. Some are unresolved down to a time resolution of 24 milliseconds. Whereas the fast flares are stronger in the red, the slow variations are bluer when brighter. The redder slopes, emitted power, and characteristic timescales of the fast flares can be explained as optically-thin synchrotron emission from a compact jet arising on size scales ~140-500 Gravitational radii (with a possible additional contribution by a thermal particle distribution). The origin of the slower variations is unclear. The optical continuum spectral slopes are strongly affected by dereddening uncertainties and contamination by strong H{alpha} emission, but the variations of these slopes follow relatively stable loci as a function of flux. Cross-correlating the slow variations between the different bands shows asymmetries on all nights consistent with a small red skew (i.e., red lag). X-ray reprocessing and non-thermal emission could both contribute to these. These data reveal a complex mix of components over five decades in timescale during the outburst., MNRAS in press (Accepted Mar 04 2016; Revised Mar 03; Reviewed Feb 22; Received Dec 22 2015), Advance Access: http://mnras.oxfordjournals.org/content/early/2016/03/14/mnras.stw571.abstract