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51. Neuroblastoma in the first year of life. The Italian contribution to a Study of the International Society of Pediatric Oncology Europe Neuroblastoma Group

Author

DI CATALDO, Andrea, Conte, M, Granata, C, Bombace, V, Giuliano, M, Paone, G, Viscardi, E, Castellano, A, Luksch, R, Bianchi, M, Miglionico, L, Provenzi, M, Tonegatti, L, Tettoni, K, Bertuna, G, DE LEONARDIS, F, Bonetti, F, Tamburini, A, Zanazzo, Ga, Pierani, P, Arcamone, G, Cosmi, C, Aru, B, Nardi, M, Fagnani, Am, Mazzarino, I, Cellini, M, Balter, R, Mastrangelo, S, Migliorati, R, Serino, R, Dangelo, P, Parigi, Gb, Pericoli, R, Bagnulo, S, Scotta, Ms, and DE BERNARDI, B.

Subjects
Neuroblastoma, Infant, Bambino
Published
2006

57. Forme argomentative nei forum on-line: analisi dell’accordo e disaccordo

Author

Lazzeri, S., Bianchi, Ivana, DE BERNARDI, B., and Savardi, U.

Subjects
online forums, online forums, dialogic structure, collaborative knowledge construction, agreement and disagreement, dialogic structure, agreement and disagreement, collaborative knowledge construction
Published
2005

58. TUMORI A CELLULE GERMINALI IN ETA' PEDIATRICA. RISULTATI DEL PROTOCOLLO AIEOP 'TG-91'

Author

Lo Curto, M., Di Pace, M., Siracusa, F., De Bernardi, B., Fagnani, A., Provenzano, G., Felic, L., Lo PIccolo, S., Santori, N., Tamaro, P., Lo Curto, M., Di Pace, M., Siracusa, F., De Bernardi, B., Fagnani, A., Provenzano, G., Felic, L., Lo PIccolo, S., Santori, N., and Tamaro, P.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Settore MED/20 - Chirurgia Pediatrica E Infantile, Tumori in età pediatrica, Tumori a Cellulu Germinali, Protocollo Nazionale
Abstract

Gli Autori riportano i risultati del Protocollo AIEOP-91 presentando igli 88 casi registrati in 15 Centro AIEOP dal gGennaio 1991 al Dicembre 193

Published
1994

65. Influence of age on stage 4 Neuroblastoma

Author

Boni, L, Casale, F, Prete, A, Jenkner, A, Carli, M, Bianchi, M, DI CATALDO, Andrea, Dangelo, P, Zanazzo, A, Tettoni, K, Favre, C, Tamburini, A, Rizzo, A, Bruzzi, P, and DE BERNARDI, B.

Published
2004

67. L'ESPLORAZIONE DEI LINFONODI REGIONALI NEL NEUROBLASTOMA LOCALIZZATO: Compliance alle Direttive Chirurgiche nello Studio Nazionale NB 85

Author

Cecchetto, G., Guglielmi, M., Dall'Igna, P., Federici, S., Siracusa, F., Boglino, C., Cuneo, G., Fagnani, A., Locatelli, G., Vecchio, P., De Bernardi, B., Cecchetto, G., Guglielmi, M., Dall'Igna, P., Federici, S., Siracusa, F., Boglino, C., Cuneo, G., Fagnani, A., Locatelli, G., Vecchio, P., and De Bernardi, B.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Settore MED/20 - Chirurgia Pediatrica E Infantile, Pediatric tumours, Neuroblastoma stage I and II, treatment, surgery, surgical exploration of regional lymphnodes
Abstract

Accurate staging of patients with Neuroblastoma is essential for prognosis and for determining the most appropriate treatment. The neoplastic involvement of regional lymph-nodes (l.n.) is an important prognostic feature; the surgical exploration of these L.n. is mandatory for localized neuroblastoma (NBL) (stage I and II) in wich surgery represent the main treatment. The Authors have carried out a retrospective analysis of the cases registered in Italy between 1985 and 1989

Published
1993

68. THE ROLE OF SURGERY (s) IN THE TREATMENT OF GERM CELL TUMORS (GCT) IN CHILDHOOD. A Report from an Italian Multi-Istitutional Study (TCG-91)

Author

Siracusa, F., Di Pace, M., Cecchetto, G., Lo Cascio, M., Boglino, C., De Bernardi, B., Montinari, :., Lo Curto, M., Siracusa, F., Di Pace, M., Cecchetto, G., Lo Cascio, M., Boglino, C., De Bernardi, B., Montinari, :., and Lo Curto, M.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Settore MED/20 - Chirurgia Pediatrica E Infantile, Solid Neoplasms in childreen, Germ Cell Tumors
Abstract

GCT account for about 3% of all solidi Neoplasms in children. Because of the confusion as to their classification, diagnostic apporoach and treatment, a multi-istitutional study was carried and a National Protocol for Diagnosis and treatment of CGT (TCG-91), approved by AIEOP, straded in January 1991.

Published
1993

69. ASPORTAZIONE DEL TUMORE PRIMITIVO NEL NEUROBLASTOMA STADIO IVs. E' UTILE NEL DECORSO CLINICO?

Author

Guglielmi, M., Federici, S., Cuneo, G., Boglino, C., Siracusa, F., Leggio, A., Cecchetto, G., Conte, M., De Bernardi, B., Di Benedetto, A., Bardini, T., Cozzi, F., Guglielmi, M., Federici, S., Cuneo, G., Boglino, C., Siracusa, F., Leggio, A., Cecchetto, G., Conte, M., De Bernardi, B., Di Benedetto, A., Bardini, T., and Cozzi, F.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Settore MED/20 - Chirurgia Pediatrica E Infantile, Tumori in età pediatrica, Neuroblastoma, neuroblastoma stadio IVs, exeresi del tumore primitinìvo
Abstract

Lo studio si propone di valutare il ruolo dell'asportazione del tumore primitivo (TP) nei bambini in età inferiore all'anno con neuroblastoma stadio IVs

Published
1993

70. IL RUOLO DELLA CHIRURGIA NEL TRATTAMENTO DEI TUMORI GERMINALI IN ETA' PEDIATRICA: Analisi dello Studio Cooperativo 'AIEOP TCG-'91

Author

Siracusa, F., Di Pace, M., Cecchetto, G., Tardino, M., Cascio, S., Dall'Igna, P., Inserra, A., Jasonni, V., Milana, E., Fagnani, A., Lo Cascio, M., De Bernardi, B., Boglino, C., Lo Curto', M., Siracusa, F., Di Pace, M., Cecchetto, G., Tardino, M., Cascio, S., Dall'Igna, P., Inserra, A., Jasonni, V., Milana, E., Fagnani, A., Lo Cascio, M., De Bernardi, B., Boglino, C., and Lo Curto', M.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, pediatric neoplasms, Germ Cell Tumors, Settore MED/20 - Chirurgia Pediatrica E Infantile
Abstract

Authors analyze the preliminary results of the first multicentric cooperative study on Germ Celkl Tumors in childhood (TCG 91). The Authors discuss the role of primary surgical procedure on the treatment of benign forms and of resectable malignant tumors.

Published
1993

72. NEUROBLASTOMA A LOCALIZZAZIONE MUSCOLARE: DESCRIZIONE DI UN CASO

Author

Siracusa, F., Tomà, P., Timitilli, A., Viscardi, E., Fabbretti, G., De Bernardi, B., Siracusa, F., Tomà, P., Timitilli, A., Viscardi, E., Fabbretti, G., and De Bernardi, B.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Settore MED/20 - Chirurgia Pediatrica E Infantile, Neuroblastoma, Magnertic Resonance
Abstract

An unusual case of abdominal neuroblastoma, whose extention involved the psoas muscle, leading to an ultrasonographic and MRN imagin simulatinf an haematoma, is described.

Published
1992

74. Paratesticular rhabdomyosarcoma: a comparison of two Italian studies

Author

Boscolo, G, Bisogno, G, Cecchetto, G, Dalligna, P, Zanetti, I, DE BERNARDI, B, CORDERO DI MONTEZEMOLO, Luca, Mancini, A, Indolfi, P, Donfrancesco, A, Tamaro, P, DI CATALDO, A, Tamburini, A, Riccardi, R, Gallismi, D, Arrighini, A, Santoro, N, and Carli, M.

Subjects
Paratesticular rhabdomyosarcoma, retroperitoneal, lymphadenectomy, primary re-excision
Published
2002

76. [Neuroblastoma. Tumor rupture as an unfavorable prognostic factor]

Author

Mascarin M, De Bernardi B, Brisigotti M, Cuneo GP, Conte M, Taccone A, Boldrini R., TAMARO, PAOLO, Mascarin, M, De Bernardi, B, Brisigotti, M, Cuneo, Gp, Conte, M, Taccone, A, Tamaro, Paolo, and Boldrini, R.

Subjects
Male, neuroblastoma, Neuroblastoma, Rupture, Spontaneous, Abdominal Neoplasms, Child, Preschool, Humans, Infant, Female, Neoplasm Recurrence, Local, Thoracic Neoplasms, Child, Prognosis
Abstract

Since there is little information regarding the possible prognostic significance of tumor rupture in localized neuroblastoma, we have analyzed the clinical courses of 163 children registered from 1979-1990 in 12 italian pediatric oncology Centers participating in the Neuroblastoma Cooperative Group of the A.I.E.O.P. (Italian Association for Paediatric Haematology-Oncology). Ten instances (6%) of tumor rupture were described. Ruptures occurred preoperatively in one child, during the operation in 9; among these 9, two were provoked by the surgeon to allow radical tumor excision, 7 were accidental. Of these 10 children, 7 relapsed at 3-25 months (median, 8 months) from diagnosis. Relapses were local in 5 children (2 of the 5 died), disseminated in one (who died), local + disseminated in one (presently alive with disease). Two local relapses were followed by bony or haematologic spread at 4 and 8 months, respectively. Of the 7 children who relapsed, 2 are alive in complete remission at 29, 100 months, respectively; two are alive with disease at 3 and 65 months, 3 died at 8, 15 and 24 months, respectively. We conclude that rupture of a localized neuroblastoma is a factor predisposing to relapse and may compromise the chance of cure. The surgeon should be aware of the risks connected with this complication and make any effort to avoid it.

Published
1991

80. Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).

Author

UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Schleiermacher, G, Michon, J, Ribeiro, A, Pierron, G, Mosseri, V, Rubie, H, Munzer, C, Bénard, J, Auger, N, Combaret, V, Janoueix-Lerosey, I, Pearson, A, Tweddle, D A, Bown, N, Gerrard, M, Wheeler, K, Noguera, R, Villamon, E, Cañete, A, Castel, V, Marques, B, de Lacerda, A, Tonini, G P, Mazzocco, K, Defferrari, R, de Bernardi, B, di Cataldo, A, van Roy, N, Brichard, Bénédicte, Ladenstein, R, Ambros, I, Ambros, P, Beiske, K, Delattre, O, Couturier, J, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Schleiermacher, G, Michon, J, Ribeiro, A, Pierron, G, Mosseri, V, Rubie, H, Munzer, C, Bénard, J, Auger, N, Combaret, V, Janoueix-Lerosey, I, Pearson, A, Tweddle, D A, Bown, N, Gerrard, M, Wheeler, K, Noguera, R, Villamon, E, Cañete, A, Castel, V, Marques, B, de Lacerda, A, Tonini, G P, Mazzocco, K, Defferrari, R, de Bernardi, B, di Cataldo, A, van Roy, N, Brichard, Bénédicte, Ladenstein, R, Ambros, I, Ambros, P, Beiske, K, Delattre, O, and Couturier, J

Abstract

In infants with stage 4s MYCN-non-amplified NB, a SCA genomic profile identifies patients who will require upfront treatment even in the absence of other clinical indication for therapy, whereas in infants with localised unresectable NB, a genomic profile characterised by the absence of SCA identifies patients in whom treatment reduction might be possible. These findings will be implemented in a future international trial.

Published
2011

81. Excellent outcome with reduced treatment in infants with nonmetastatic and unresectable neuroblastoma without MYCN amplification: results of the prospective INES 99.1.

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Brichard, Bénédicte, Rubie, H, De Bernardi, B., Gerard, M, Canete, A, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Brichard, Bénédicte, Rubie, H, De Bernardi, B., Gerard, M, and Canete, A

Abstract

To evaluate the efficacy of low-dose chemotherapy in infants with nonmetastatic and unresectable neuroblastoma (NB) without MYCN amplification.

Published
2011

87. Germ cell tumors in childhood | [Tumori a cellule germinali in età pediatrica]

Author

Lo Curto, M, Lo Piccolo MS, Arrighini, A, Bagnulo, S, Bernini, C, Carli, M, Cecchetto, G, De Grazia, E, De Laurentis, T, DI CATALDO, Andrea, Di Pace MR, Fagnani, Am, Favre, C, Indolfi, P, Marradi, G, Massolo, F, Mazzarino, I, Mazzeo, L, Menna, G, Putamigno, P, Santoro, N, Siracusa, F, Tamaro, P, Targhetta, P, Riv Ital Pediatr 23:414 421, De Bernardi B. Tumori a. cellule germinali in età p. e. d. i. a. t. r. i. c. a., and 1997

Subjects
Seminomatous Tumors, Teratoma, Germ Cell Tumor
Published
1997

90. SIOPEN-R-NET

Author

Schreier, G, Meßmer, J, Marko, W, Sabaini, P, Kreiner, K, Michon, J, De Bernardi, B, Castel, V, Pearson, A, Ladenstein, R, Schreier, G, Meßmer, J, Marko, W, Sabaini, P, Kreiner, K, Michon, J, De Bernardi, B, Castel, V, Pearson, A, and Ladenstein, R

Published
2004

93. Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)

Author

Schleiermacher, G, primary, Michon, J, additional, Ribeiro, A, additional, Pierron, G, additional, Mosseri, V, additional, Rubie, H, additional, Munzer, C, additional, Bénard, J, additional, Auger, N, additional, Combaret, V, additional, Janoueix-Lerosey, I, additional, Pearson, A, additional, Tweddle, D A, additional, Bown, N, additional, Gerrard, M, additional, Wheeler, K, additional, Noguera, R, additional, Villamon, E, additional, Cañete, A, additional, Castel, V, additional, Marques, B, additional, de Lacerda, A, additional, Tonini, G P, additional, Mazzocco, K, additional, Defferrari, R, additional, de Bernardi, B, additional, di Cataldo, A, additional, van Roy, N, additional, Brichard, B, additional, Ladenstein, R, additional, Ambros, I, additional, Ambros, P, additional, Beiske, K, additional, Delattre, O, additional, and Couturier, J, additional

Published
2011
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95. [The prognostic effect of amplification of the MYCN oncogene in neuroblastoma. The preliminary results of the Italian Cooperative Group for Neuroblastoma (GCINB)]

Author

Pession A, De Bernardi B, Perri P, Katia Mazzocco, Rondelli R, Nigro M, Iolascon A, Forni M, Basso G, and Conte M

Subjects
Male, Adolescent, Statistics as Topic, Gene Amplification, Genes, myc, Infant, Newborn, Infant, DNA, Neoplasm, Prognosis, Neuroblastoma, Italy, Child, Preschool, Humans, Female, Child
Abstract

Of 567 children with neuroblastoma diagnosed between November 1984 and May 1993 in 21 Italian institutions, 235 (41%) have been evaluated for MYCN oncogene amplification. The amplification (3 or more copies of the gene) was found in 39 patients (17%) and was more frequent in patients aged more than one year, abdominal primary site of the tumor, advanced stages, normal urinary excretion of vanillylmandelic acid (VMA), and high level of LDH, NSE and ferritin. The five-year survival of the 235 patients (62%) was significantly better in patients with normal copy number of MYCN (69% versus 29%). By correlating genomic amplification with clinical and biochemical characteristics, MYCN amplification was found associated with a worse prognosis even when patients were subdivided for age (under and above one year), disease extension (localized operable, localized but inoperable, and disseminated) with exception for Stage IV-S, VMA and homovanillic acid excretion, serum levels of NSE and ferritin, but not of LDH. These data confirm the unfavourable prognostic meaning of MYCN amplification, but are unable to define if it represents a new independent variable.

Published
1994

96. GERM CELL TUMOURS IN CHILDREN- A Report of 84 Cases

Author

Lo Curto, M., Provenzano, G., Zingone, A., Bagnulo, S., Cecchetto, G., Siracusa, F., De Bernardi, B., Di Pace, M., Tamaro, P., and Targhetta, R.

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Settore MED/20 - Chirurgia Pediatrica E Infantile, paediatric neoplasms, Germ Cell tumours
Published
1994

100. Disseminated poor-risk neuroblastoma. Results of an 'intensive' protocol (AIEOP NB-85). [Neuroblastoma disseminato a cattiva prognosi. Risultati di un protocollo intensivo (AIEOP NB-85)]

Author

Corciulo, P, Deb, G, Mazzei, A, Bisogno, G, Surico, Gm, Tonello, M, Garaventa, A, Arrighini, A, Lumia, F, Zanazzo, G, Gallisai, D, Massolo, F, Cornelli, Pe, Targhetta, R, DI CATALDO, Andrea, Ragusa, R, Acquaviva, A, Bernini, G, Fiorillo, A, Santoro, N, Ivani, G, Zucchetti, P, Cominetti, M, Viscardi, E, Castagnola, E, and De Bernardi, B.

Published
1993

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