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51. THE EFFECTS OF INDUCED BLOOD PRESSURE INCREASE AND DECREASE ON CEREBRAL SMALL VESSELS: THE HYPERINTENSE STUDY

Author

Janssen, Esther, primary, Ter Telgte, Annemieke, additional, Verburgt, Esmée, additional, De Jong, Joost, additional, Marques, José, additional, Kessels, Roy, additional, Backes, Walter, additional, Maas, Marnix, additional, Meijer, Anton, additional, Deinum, Jaap, additional, Riksen, Niels, additional, Tuladhar, Anil, additional, and De Leeuw, Frank-Erik, additional

Published
2022
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53. The Hyperintense study: Assessing the effects of induced blood pressure increase and decrease on MRI markers of cerebral small vessel disease: Study rationale and protocol

Author

Janssen, Esther, primary, ter Telgte, Annemieke, additional, Verburgt, Esmée, additional, de Jong, Joost JA, additional, Marques, José P, additional, Kessels, Roy PC, additional, Backes, Walter H, additional, Maas, Marnix C, additional, Meijer, Frederick JA, additional, Deinum, Jaap, additional, Riksen, Niels P, additional, Tuladhar, Anil M, additional, and de Leeuw, Frank-Erik, additional

Published
2022
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57. Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma

Author

Bliziotis, Nikolaos G., primary, Kluijtmans, Leo A. J., additional, Soto, Sebastian, additional, Tinnevelt, Gerjen H., additional, Langton, Katharina, additional, Robledo, Mercedes, additional, Pamporaki, Christina, additional, Engelke, Udo F. H., additional, Erlic, Zoran, additional, Engel, Jasper, additional, Deutschbein, Timo, additional, Nölting, Svenja, additional, Prejbisz, Aleksander, additional, Richter, Susan, additional, Prehn, Cornelia, additional, Adamski, Jerzy, additional, Januszewicz, Andrzej, additional, Reincke, Martin, additional, Fassnacht, Martin, additional, Eisenhofer, Graeme, additional, Beuschlein, Felix, additional, Kroiss, Matthias, additional, Wevers, Ron A., additional, Jansen, Jeroen J., additional, Deinum, Jaap, additional, and Timmers, Henri J. L. M., additional

Published
2021
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62. Improvement in quality of life and psychological symptoms after treatment for primary aldosteronism: Asian Cohort Study

Author

Tan, Yen Kheng, primary, Kwan, Yu Heng, additional, Teo, David Choon Liang, additional, Velema, Marieke, additional, Deinum, Jaap, additional, Tan, Pei Ting, additional, Zhang, Meifen, additional, Khoo, Joan Joo Ching, additional, Loh, Wann Jia, additional, Gani, Linsey, additional, King, Thomas F J, additional, Tan, Eberta Jun Hui, additional, Soh, Shui Boon, additional, Au, Vanessa Shu Chuan, additional, Tay, Tunn Lin, additional, Dacay, Lily Mae Quevedo, additional, Ng, Keng Sin, additional, Wong, Kang Min, additional, Wong, Andrew Siang Yih, additional, Ng, Foo Cheong, additional, Aw, Tar Choon, additional, Chan, Yvonne Hui Bin, additional, Tong, Khim Leng, additional, Lee, Sheldon Shao Guang, additional, Chai, Siang Chew, additional, and Puar, Troy Hai Kiat, additional

Published
2021
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63. Pre- Versus Post-Operative Untargeted Plasma Nuclear Magnetic Resonance Spectroscopy Metabolomics of Pheochromocytoma And Paraganglioma

Author

Bliziotis, Nikolaos Georgios, primary, Kluijtmans, Leo AJ, additional, Soto, Sebastian, additional, Tinnevelt, Gerjen H, additional, Langton, Katharina, additional, Robledo, Mercedes, additional, Pamporaki, Christina, additional, Engelke, Udo FH, additional, Erlic, Zoran, additional, Engel, Jasper, additional, Deutschbein, Timo, additional, Nölting, Svenja, additional, Prejbisz, Aleksander, additional, Richter, Susan, additional, Prehn, Cornelia, additional, Adamski, Jerzy, additional, Januszewicz, Andrzej, additional, Reincke, Martin, additional, Fassnacht, Martin, additional, Eisenhofer, Graeme, additional, Beuschlein, Felix, additional, Kroiss, Matthias, additional, Wevers, Ron A, additional, Jansen, Jeroen J, additional, Deinum, Jaap, additional, and Timmers, Henri JLM, additional

Published
2021
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64. Identification of Surgically Curable Primary Aldosteronism by Imaging in a Large, Multiethnic International Study

Author

Rossi, Gian Paolo, primary, Crimì, Filippo, additional, Rossitto, Giacomo, additional, Amar, Laurence, additional, Azizi, Michel, additional, Riester, Anna, additional, Reincke, Martin, additional, Degenhart, Christoph, additional, Widimsky, Jiri, additional, Naruse, Mitsuhide, additional, Deinum, Jaap, additional, Schultze Kool, Leo, additional, Kocjan, Tomaz, additional, Negro, Aurelio, additional, Rossi, Ermanno, additional, Kline, Gregory, additional, Tanabe, Akiyo, additional, Satoh, Fumitoshi, additional, Christian Rump, Lars, additional, Vonend, Oliver, additional, Willenberg, Holger S, additional, Fuller, Peter J, additional, Yang, Jun, additional, Chee, Nicholas Yong Nian, additional, Magill, Steven B, additional, Shafigullina, Zulfiya, additional, Quinkler, Marcus, additional, Oliveras, Anna, additional, Cent Wu, Vin, additional, Kratka, Zuzana, additional, Barbiero, Giulio, additional, Seccia, Teresa Maria, additional, and Battistel, Michele, additional

Published
2021
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65. Adrenal venous sampling guided adrenalectomy rates in primary aldosteronism: results of an international cohort (AVSTAT)

Author

Ohno, Youichi, Naruse, Mitsuhide, Beuschlein, Felix, Schreiner, Florentine, Parasiliti-Caprino, Mirko, Deinum, Jaap, Drake, William M, Fallo, Francesco, Fuss, Carmina T, Grytaas, Marianne A, Ichijo, Takamasa, Inagaki, Nobuya, Kakutani, Miki, Kastelan, Darko, Kraljevic, Ivana, Katabami, Takuyuki, Kocjan, Tomaz, Monticone, Silvia, Mulatero, Paolo, O'Toole, Sam, Kobayashi, Hiroki, Sone, Masakatsu, Tsuiki, Mika, Wada, Norio, Williams, Tracy Ann, Reincke, Martin, Tanabe, Akiyo, and University of Zurich

Subjects
10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health
Published
2021
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66. Clinical presentation and long-term follow-up of dopamine beta hydroxylase deficiency

Author

Wassenberg, Tessa, Deinum, Jaap, van Ittersum, Frans J., Kamsteeg, Erik Jan, Pennings, Maartje, Verbeek, Marcel M., Wevers, Ron A., van Albada, Mirjam E., Kema, Ido P., Versmissen, Jorie, van den Meiracker, Ton, Lenders, Jacques W.M., Monnens, Leo, Willemsen, Michèl A., Wassenberg, Tessa, Deinum, Jaap, van Ittersum, Frans J., Kamsteeg, Erik Jan, Pennings, Maartje, Verbeek, Marcel M., Wevers, Ron A., van Albada, Mirjam E., Kema, Ido P., Versmissen, Jorie, van den Meiracker, Ton, Lenders, Jacques W.M., Monnens, Leo, and Willemsen, Michèl A.

Abstract

Dopamine beta hydroxylase (DBH) deficiency is an extremely rare autosomal recessive disorder with severe orthostatic hypotension, that can be treated with L-threo-3,4-dihydroxyphenylserine (L-DOPS). We aimed to summarize clinical, biochemical, and genetic data of all world-wide reported patients with DBH-deficiency, and to present detailed new data on long-term follow-up of a relatively large Dutch cohort. We retrospectively describe 10 patients from a Dutch cohort and 15 additional patients from the literature. We identified 25 patients (15 females) from 20 families. Ten patients were diagnosed in the Netherlands. Duration of follow-up of Dutch patients ranged from 1 to 21 years (median 13 years). All patients had severe orthostatic hypotension. Severely decreased or absent (nor)epinephrine, and increased dopamine plasma concentrations were found in 24/25 patients. Impaired kidney function and anemia were present in all Dutch patients, hypomagnesaemia in 5 out of 10. Clinically, all patients responded very well to L-DOPS, with marked reduction of orthostatic complaints. However, orthostatic hypotension remained present, and kidney function, anemia, and hypomagnesaemia only partially improved. Plasma norepinephrine increased and became detectable, while epinephrine remained undetectable in most patients. We confirm the core clinical characteristics of DBH-deficiency and the pathognomonic profile of catecholamines in body fluids. Impaired renal function, anemia, and hypomagnesaemia can be part of the clinical presentation. The subjective response to L-DOPS treatment is excellent and sustained, although the neurotransmitter profile in plasma does not normalize completely. Furthermore, orthostatic hypotension as well as renal function, anemia, and hypomagnesaemia improve only partially.

Published
2021

67. Targeted metabolomics as a tool in discriminating endocrine from primary hypertension

Author

Erlic, Zoran; https://orcid.org/0000-0001-6953-9133, Reel, Parminder, Reel, Smarti, Amar, Laurence, Pecori, Alessio, Larsen, Casper K, Tetti, Martina, Pamporaki, Christina, Prehn, Cornelia, Prejbisz, Aleksander; https://orcid.org/0000-0001-7085-0244, Adamski, Jerzy, Ceccato, Filippo, Scaroni, Carla, Kroiss, Matthias, Dennedy, Michael C, Deinum, Jaap, Langton, Katharina, Mulatero, Paolo, Reincke, Martin, Lenzini, Livia, Gimenez-Roqueplo, Anne-Paule, Assié, Guillaume, Blanchard, Anne, Zennaro, Maria-Christina, Jefferson, Emily, Beuschlein, Felix, Erlic, Zoran; https://orcid.org/0000-0001-6953-9133, Reel, Parminder, Reel, Smarti, Amar, Laurence, Pecori, Alessio, Larsen, Casper K, Tetti, Martina, Pamporaki, Christina, Prehn, Cornelia, Prejbisz, Aleksander; https://orcid.org/0000-0001-7085-0244, Adamski, Jerzy, Ceccato, Filippo, Scaroni, Carla, Kroiss, Matthias, Dennedy, Michael C, Deinum, Jaap, Langton, Katharina, Mulatero, Paolo, Reincke, Martin, Lenzini, Livia, Gimenez-Roqueplo, Anne-Paule, Assié, Guillaume, Blanchard, Anne, Zennaro, Maria-Christina, Jefferson, Emily, and Beuschlein, Felix

Abstract

Context Identification of patients with endocrine forms of hypertension (EHT) (primary hyperaldosteronism [PA], pheochromocytoma/paraganglioma [PPGL], and Cushing syndrome [CS]) provides the basis to implement individualized therapeutic strategies. Targeted metabolomics (TM) have revealed promising results in profiling cardiovascular diseases and endocrine conditions associated with hypertension. Objective Use TM to identify distinct metabolic patterns between primary hypertension (PHT) and EHT and test its discriminating ability. Methods Retrospective analyses of PHT and EHT patients from a European multicenter study (ENSAT-HT). TM was performed on stored blood samples using liquid chromatography mass spectrometry. To identify discriminating metabolites a “classical approach” (CA) (performing a series of univariate and multivariate analyses) and a “machine learning approach” (MLA) (using random forest) were used. The study included 282 adult patients (52% female; mean age 49 years) with proven PHT (n = 59) and EHT (n = 223 with 40 CS, 107 PA, and 76 PPGL), respectively. Results From 155 metabolites eligible for statistical analyses, 31 were identified discriminating between PHT and EHT using the CA and 27 using the MLA, of which 16 metabolites (C9, C16, C16:1, C18:1, C18:2, arginine, aspartate, glutamate, ornithine, spermidine, lysoPCaC16:0, lysoPCaC20:4, lysoPCaC24:0, PCaeC42:0, SM C18:1, SM C20:2) were found by both approaches. The receiver operating characteristic curve built on the top 15 metabolites from the CA provided an area under the curve (AUC) of 0.86, which was similar to the performance of the 15 metabolites from MLA (AUC 0.83). Conclusion TM identifies distinct metabolic pattern between PHT and EHT providing promising discriminating performance.

Published
2021

72. A comparison of high‑throughput plasma NMR protocols for comparative untargeted metabolomics (Metabolomics

Author

Bliziotis, Nikolaos G., Engelke, Udo F.H., Aspers, Ruud L.E.G., Engel, Jasper, Deinum, Jaap, Timmers, Henri J.L.M., Wevers, Ron A., Kluijtmans, Leo A.J., Bliziotis, Nikolaos G., Engelke, Udo F.H., Aspers, Ruud L.E.G., Engel, Jasper, Deinum, Jaap, Timmers, Henri J.L.M., Wevers, Ron A., and Kluijtmans, Leo A.J.

Abstract

Following publication of the original article, the authors would like to correct a sentence in the paragraph “1H-NMR spectra were recorded at 298 K…” under the heading “NMR experiments”. The sentence currently reads: “The LED pulse sequence had the form -RD-901-G1- 1801-G1-901-G2-T-901-G1-1801-G1-901-G2-t-901-acquire FID, where RD is a relaxation delay, 901 is a 901 RF pulse, G1 is the pulsed-field gradient that is applied to allow editing, 1801 is a 1801 RF pulse, G2 is a spoil gradient applied to remove unwanted magnetization components. The diffusion delay Δ is the time during which the molecules are allowed to diffuse—this is the period (901-G1-1801-G1- 901-G2-T-); and t is a delay to allow the longitudinal eddy currents caused within the sample to decay (Beckonert et al. 2007).” The sentence should read: “The LED pulse sequence had the form -RD-90°-G1- 180°-G1-90°-G2-T-90°-G1-180°-G1-90°-G2-t-90°-acquire FID, where RD is a relaxation delay, 90° is a 90° RF pulse, G1 is the pulsed-field gradient that is applied to allow editing, 180° is a 180° RF pulse, G2 is a spoil gradient applied to remove unwanted magnetization components. The diffusion delay ? is the time during which the molecules are allowed to diffuse—this is the period (90°-G1-180°-G1-90°-G2 T-); and t is a delay to allow the longitudinal eddy currents caused within the sample to decay (Beckonert et al. 2007).” This has been corrected with this erratum.

Published
2020

73. Glucocorticoid excess in patients with pheochromocytoma compared to paraganglioma and other forms of hypertension

Author

Constantinescu, Georgiana, Langton, Katharina, Conrad, Catleen, Amar, Laurence, Assié, Guillaume, Gimenez-Roqueplo, Anne-Paule, Blanchard, Anne, Larsen, Casper K, Mulatero, Paolo, Williams, Tracy Ann, Prejbisz, Aleksander, Fassnacht, Martin, Bornstein, Stefan, Ceccato, Filippo, Fliedner, Stephanie, Dennedy, Michael, Peitzsch, Mirko, Sinnott, Richard, Januszewicz, Andrzej, Beuschlein, Felix, Reincke, Martin, Zennaro, Maria-Christina, Eisenhofer, Graeme, Deinum, Jaap, Constantinescu, Georgiana, Langton, Katharina, Conrad, Catleen, Amar, Laurence, Assié, Guillaume, Gimenez-Roqueplo, Anne-Paule, Blanchard, Anne, Larsen, Casper K, Mulatero, Paolo, Williams, Tracy Ann, Prejbisz, Aleksander, Fassnacht, Martin, Bornstein, Stefan, Ceccato, Filippo, Fliedner, Stephanie, Dennedy, Michael, Peitzsch, Mirko, Sinnott, Richard, Januszewicz, Andrzej, Beuschlein, Felix, Reincke, Martin, Zennaro, Maria-Christina, Eisenhofer, Graeme, and Deinum, Jaap

Abstract

Context: Catecholamines and adrenocortical steroids are important regulators of blood pressure. Bidirectional relationships between adrenal steroids and catecholamines have been established but whether this is relevant to patients with pheochromocytoma is unclear. Objective: This study addresses the hypothesis that patients with pheochromocytoma and paraganglioma (PPGL) have altered steroid production compared to primary hypertensives. Design: Multicenter cross-sectional study. Setting: Twelve European referral centers. Patients: Subjects included 182 patients with pheochromocytoma, 36 with paraganglioma and 270 primary hypertensives. Patients with primary aldosteronism (n=461) and Cushing syndrome (n=124) were included for additional comparisons. Intervention: In patients with PPGLs, surgical resection of tumors. Outcome measures: Differences in mass spectrometry-based profiles of 15 adrenal steroids between groups and after surgical resection of PPGLs. Relationships of steroids to plasma and urinary metanephrines and urinary catecholamines. Results: Patients with pheochromocytoma had higher (P<0.05) circulating concentrations of cortisol, 11-deoxycortisol, 11-deoxycorticosterone and corticosterone than primary hypertensives. Concentrations of cortisol, 11-deoxycortisol and corticosterone were also higher (P<0.05) in patients with pheochromocytoma than with paraganglioma. These steroids correlated positively with plasma and urinary metanephrines and catecholamines in patients with pheochromocytoma, but not paraganglioma. After adrenalectomy, there were significant decreases in cortisol, 11-deoxycortisol, corticosterone, 11-deoxycorticosterone, aldosterone and 18-oxocortisol. Conclusions: This is the first large study in patients with PPGLs that supports in a clinical setting the concept of adrenal cortical-medullary interactions involving an influence of catecholamines on adrenal steroids. These findings could have implications for the cardiovascular complications

Published
2020

74. Drug-resistant hypertension in primary aldosteronism patients undergoing adrenal vein sampling: the AVIS-2-RH study

Author

Rossi, Gian Paolo, primary, Rossitto, Giacomo, additional, Amar, Laurence, additional, Azizi, Michel, additional, Riester, Anna, additional, Reincke, Martin, additional, Degenhart, Christoph, additional, Widimsky, Jiri, additional, Naruse, Mitsuhide, additional, Deinum, Jaap, additional, Schultze Kool, Leo, additional, Kocjan, Tomaz, additional, Negro, Aurelio, additional, Rossi, Ermanno, additional, Kline, Gregory, additional, Tanabe, Akiyo, additional, Satoh, Fumitoshi, additional, Rump, Lars Christian, additional, Vonend, Oliver, additional, Willenberg, Holger S, additional, Fuller, Peter J, additional, Yang, Jun, additional, Chee, Nicholas Yong Nian, additional, Margill, Steven B, additional, Shafigullina, Zulfiya, additional, Quinkler, Marcus, additional, Oliveras, Anna, additional, Lee, Bo-Ching, additional, Wu, Vin Cent, additional, Kratka, Zuzana, additional, Seccia, Teresa M, additional, and Lenzini, Livia, additional

Published
2021
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76. The Adrenal Vein Sampling International Study (AVIS) for Identifying the Major Subtypes of Primary Aldosteronism

Author

Rossi, Gian Paolo, Barisa, Marlena, Allolio, Bruno, Auchus, Richard J., Amar, Laurence, Cohen, Debbie, Degenhart, Christoph, Deinum, Jaap, Fischer, Evelyn, Gordon, Richard, Kickuth, Ralph, Kline, Gregory, Lacroix, Andre, Magill, Steven, Miotto, Diego, Naruse, Mitsuhide, Nishikawa, Tetsuo, Omura, Masao, Pimenta, Eduardo, Plouin, Pierre-François, Quinkler, Marcus, Reincke, Martin, Rossi, Ermanno, Rump, Lars Christian, Satoh, Fumitoshi, Schultze Kool, Leo, Seccia, Teresa Maria, Stowasser, Michael, Tanabe, Akiyo, Trerotola, Scott, Vonend, Oliver, Widimsky, Jiri, Jr., Wu, Kwan-Dun, Wu, Vin-Cent, and Pessina, Achille Cesare

Published
2012

78. Targeted Metabolomics as a Tool in Discriminating Endocrine From Primary Hypertension

Author

Erlic, Zoran, primary, Reel, Parminder, additional, Reel, Smarti, additional, Amar, Laurence, additional, Pecori, Alessio, additional, Larsen, Casper K, additional, Tetti, Martina, additional, Pamporaki, Christina, additional, Prehn, Cornelia, additional, Adamski, Jerzy, additional, Prejbisz, Aleksander, additional, Ceccato, Filippo, additional, Scaroni, Carla, additional, Kroiss, Matthias, additional, Dennedy, Michael C, additional, Deinum, Jaap, additional, Langton, Katharina, additional, Mulatero, Paolo, additional, Reincke, Martin, additional, Lenzini, Livia, additional, Gimenez-Roqueplo, Anne-Paule, additional, Assié, Guillaume, additional, Blanchard, Anne, additional, Zennaro, Maria Christina, additional, Jefferson, Emily, additional, and Beuschlein, Felix, additional

Published
2020
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79. Clinical presentation and long‐term follow‐up of dopamine beta hydroxylase deficiency

Author

Wassenberg, Tessa, primary, Deinum, Jaap, additional, Ittersum, Frans J., additional, Kamsteeg, Erik‐Jan, additional, Pennings, Maartje, additional, Verbeek, Marcel M., additional, Wevers, Ron A., additional, Albada, Mirjam E., additional, Kema, Ido P., additional, Versmissen, Jorie, additional, Meiracker, Ton, additional, Lenders, Jacques W.M., additional, Monnens, Leo, additional, and Willemsen, Michèl A., additional

Published
2020
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80. Adrenal Venous Sampling–Guided Adrenalectomy Rates in Primary Aldosteronism: Results of an International Cohort (AVSTAT)

Author

Ohno, Youichi, primary, Naruse, Mitsuhide, additional, Beuschlein, Felix, additional, Schreiner, Florentine, additional, Parasiliti-Caprino, Mirko, additional, Deinum, Jaap, additional, Drake, William M, additional, Fallo, Francesco, additional, Fuss, Carmina T, additional, Grytaas, Marianne A, additional, Ichijo, Takamasa, additional, Inagaki, Nobuya, additional, Kakutani, Miki, additional, Kastelan, Darko, additional, Kraljevic, Ivana, additional, Katabami, Takuyuki, additional, Kocjan, Tomaz, additional, Monticone, Silvia, additional, Mulatero, Paolo, additional, O’Toole, Sam, additional, Kobayashi, Hiroki, additional, Sone, Masakatsu, additional, Tsuiki, Mika, additional, Wada, Norio, additional, Williams, Tracy Ann, additional, Reincke, Martin, additional, and Tanabe, Akiyo, additional

Published
2020
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81. Pheochromocytoma Concealed By Chronic Methamphetamine Abuse

Author

Constantinescu, Georgiana, primary, Leike, Steffen, additional, Gruber, Matthias, additional, Langton, Katharina, additional, Kunath, Carola, additional, Peitzsch, Mirko, additional, Deinum, Jaap, additional, Eisenhofer, Graeme, additional, and Lenders, Jacques, additional

Published
2020
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82. Mass spectrometry reveals misdiagnosis of primary aldosteronism with scheduling for adrenalectomy due to immunoassay interference

Author

Constantinescu, Georgiana, primary, Bidlingmaier, Martin, additional, Gruber, Matthias, additional, Peitzsch, Mirko, additional, Poitz, David M., additional, van Herwaarden, Antonius E., additional, Langton, Katharina, additional, Kunath, Carola, additional, Reincke, Martin, additional, Deinum, Jaap, additional, Lenders, Jacques W.M., additional, Hofmockel, Thomas, additional, Bornstein, Stefan R., additional, and Eisenhofer, Graeme, additional

Published
2020
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83. Glucocorticoid Excess in Patients with Pheochromocytoma Compared with Paraganglioma and Other Forms of Hypertension

Author

Constantinescu, Georgiana, primary, Langton, Katharina, additional, Conrad, Catleen, additional, Amar, Laurence, additional, Assié, Guillaume, additional, Gimenez-Roqueplo, Anne-Paule, additional, Blanchard, Anne, additional, Larsen, Casper K, additional, Mulatero, Paolo, additional, Williams, Tracy Ann, additional, Prejbisz, Aleksander, additional, Fassnacht, Martin, additional, Bornstein, Stefan, additional, Ceccato, Filippo, additional, Fliedner, Stephanie, additional, Dennedy, Michael, additional, Peitzsch, Mirko, additional, Sinnott, Richard, additional, Januszewicz, Andrzej, additional, Beuschlein, Felix, additional, Reincke, Martin, additional, Zennaro, Maria-Christina, additional, Eisenhofer, Graeme, additional, and Deinum, Jaap, additional

Published
2020
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84. Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity

Author

van der Heijden, Charlotte D C C, primary, ter Horst, Rob, additional, van den Munckhof, Inge C L, additional, Schraa, Kiki, additional, de Graaf, Jacqueline, additional, Joosten, Leo A B, additional, Danser, A H Jan, additional, Netea, Mihai G, additional, Deinum, Jaap, additional, Rutten, Joost, additional, and Riksen, Niels P, additional

Published
2020
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88. The effect of balloon angioplasty on hypertension in atherosclerotic renal-artery stenosis

Author

Jaarsveld, Brigit C. van, Krijnen, Pieta, Pieterman, Herman, Derkx, Frans H.M., Deinum, Jaap, Postma, Cornelis T., Dees, Ad, Woittiez, Arend J.J., Bartelink, Anton K.M., Veld, Arie J. Man in 't, and Schalekamp, Maarten A.D.H.

Subjects
Renal artery obstruction -- Care and treatment, Transluminal angioplasty -- Evaluation, Hypertension -- Care and treatment, Antihypertensive drugs -- Evaluation
Abstract

Balloon angioplasty is no more effective than antihypertensive drugs in treating patients with hypertension and renal artery stenosis. Stenosis is the medical term for any condition that blocks an artery. In this case, it's the renal artery, which supplies blood to the kidneys. Balloon angioplasty is used to remove the blockage. However, in a study of 106 patients with hypertension and renal artery stenosis who were randomly assigned to drug therapy or balloon angioplasty, outcomes were similar in both groups.

Published
2000

90. Drug-resistant hypertension in primary aldosteronism patients undergoing adrenal vein sampling: the AVIS-2-RH study.

Author

Rossi, Gian Paolo, Rossitto, Giacomo, Amar, Laurence, Azizi, Michel, Riester, Anna, Reincke, Martin, Degenhart, Christoph, Widimsky, Jiri, Naruse, Mitsuhide, Deinum, Jaap, Kool, Leo Schultze, Kocjan, Tomaz, Negro, Aurelio, Rossi, Ermanno, Kline, Gregory, Tanabe, Akiyo, Satoh, Fumitoshi, Rump, Lars Christian, Vonend, Oliver, and Willenberg, Holger S

Published
2022
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