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We construct fractional branes in Landau-Ginzburg orbifold categories and study their behavior under marginal closed string perturbations. This approach is shown to be more general than the rational boundary state construction. In particular we find new D-branes on the quintic -- such as a single D0-brane -- which are not restrictions of bundles on the ambient projective space. We also exhibit a family of deformations of the D0-brane in the Landau-Ginzburg category parameterized by points on the Fermat quintic.

This study explored the influence of five multicultural personality traits (i.e., Cultural Empathy, Open-Mindedness, Social Initiative, Emotional Stability, Flexibility) in predicting management styles (i.e., Integrating, Obliging, Compromising, Dominating, Avoiding) adopted by teachers from five European countries (Austria, Belgium, Germany, Italy, Spain) to deal with intercultural conflict that may arise within classes with and between students. Potential differences according to socio-demographic characteristics (i.e., Gender, Age, Working Seniority, Country of belonging) were also examined. Data from 589 secondary school teachers indicated that teachers who were more open-minded reported greater adoption of Integrating and Obliging styles when managing intercultural conflicts with and between students; while teachers who were less culturally empathic and flexible were more likely to adopt the Dominating style, and those who possess lower social initiative and flexibility were more likely to adopt the Avoiding style. Teachers who possess lower levels of emotional stability showed greater adoption of the Obliging style. Differences across socio-demographic characteristics were also found. Findings provided evidence to develop interventions aiming to foster effectiveness in classroom management of intercultural conflicts by underlining how multicultural personality may influence teachers’ ways to act and adjust to the educational demands of the increasingly multicultural school environment.

The COVID-19 pandemic has accelerated the adoption of digital tools for learning. Experiential learning, a crucial process in the educational pathway, can also be promoted at a distance. This paper describes HAB, hyper-activity books and serious games (SG) as methodologies to be used for assessment and training that overcome physical distancing due to COVID-19 in learning. We introduce some examples of these methodologies. The experiences and results represent a pool of resources for experiential learning in everyday educational practice and not merely for responding to emergencies caused by pandemics.

Social robots are developed to provide companionship and assistance in the daily life of the children, older, and disable people but also have great potential as educational technology by facilitating learning. In these application areas, a social robot can take the role of a coach by training and assisting individuals also in cognitive tasks. Since a robot’s interaction style affects users’ trust and acceptance, customizing its behavior to the proposed tasks could, potentially, have an impact on the users’ performance. To investigate these phenomena, we enrolled sixty volunteers and endowed a social robot with a friendly and an authoritarian interaction style. The aim was to explore whether and how the robot’s interaction style could enhance users’ cognitive performance during a psychometric evaluation. The results showed that the authoritarian interaction style seems to be more appropriate to improve the performance when the tasks require high cognitive demands. These differences in cognitive performance between the groups did not depend on users’ intrinsic characteristics, such as gender and personality traits. Nevertheless, in the authoritarian condition, participants’ cognitive performance was related to their trust and the acceptance of the technology. Finally, we found that users’ non-compliant behavior was not related to their personality traits. This finding indirectly supports the role of the robot’s interaction style in influencing the compliance behavior of the users.

In the present paper, the experience of the C0D1NC project (Coding for inclusion) is described. In this project an innovative methodology based on peer-education is the core of the educational approach. High school students become “teachers” as they are trained to teach coding and robotics to younger students. This approach favors inclusion and digital inclusion. To affirm this, we evaluated different aspects: relations between peers, perceived self-efficacy, and attitude towards technology at the beginning of activities (pre-test) and the end (post-test). Results indicate that this approach can be effective to favor personal growth, improved relations between peers, and increased self-efficacy too.

Background: Although most of the analyses included transverse colon cancers (TCC) among right colon cancer (RCC), it is not completely clear if they present total similarities with RCC or if they have their specific features. Therefore, we present an observational study to evaluate clinicopathological characteristics and survival data of patients with TCC. Methods: We retrospectively reviewed 450 RCC, of whom 97 stages I&ndash, IV TCC were included in this multicenter study, clinicopathological and molecular parameters were analyzed to identify prognostic factors for disease-free survival (DFS) and overall survival (OS). Results: Most of TCC cases were male (61%), with &le, 70 years old (62%), and good performance status (ECOG PS 0, 68%). According to WHO classification, 41 (49%) and 40 (48%) tumors were classified as well to moderate and poorly/undifferentiated respectively, regardless of mucinous component (30%). About molecular data, 8 (26%), 45 (63%), and 14 (24%) were MSI-H, KRAS wild-type, and BRAF V600E mutant, respectively. With a median follow-up of 34 months, there were 29 and 50 disease recurrences and deaths respectively. Charlson comorbidity index &ge, 5 was a significant prognostic factor for DFS (HR = 7.67, 95% CI 2.27&ndash, 25.92). Colon obstruction/perforation (HR = 2.65, 95% CI 1.01&ndash, 7.01), and BRAF mutant (HR = 3.03, 95% CI 0.97&ndash, 9.50) cases showed a worst, despite not statistically significant, DFS. Whereas for OS, at the multivariate model, only tumor grade differentiation (HR = 5.26, 95% CI 1.98&ndash, 14.01) and BRAF mutation status (3.71, 95% CI 1.07&ndash, 12.89) were independent prognostic factors. Conclusions: Poorly/undifferentiated tumor grade and BRAF V600E mutation are independent prognostic factors for OS in TCC. Further prospective clinical trials are needed to better define TCC treatment in order to improve patient outcome.

Background: The optimal anti-angiogenic strategy as second-line treatment in RAS wild-type metastatic colorectal cancer (mCRC) treated with anti-EGFR (Epidermal Growth Factor Receptor) based first-line treatment is still debated. Methods: This multicenter, real-world, retrospective study is aimed at evaluating the effectiveness of second-line Bevacizumab- and Aflibercept-based treatments after an anti-EGFR based first-line regimen. Clinical outcomes measured were: objective response rate (ORR), progression free survival (PFS), overall survival (OS) and adverse events (AEs) profiles. Results: From February 2011 to October 2019, 277 consecutive mCRC patients received Bevacizumab-based (228, 82.3%) or Aflibercept-based (49, 17.7%) regimen. No significant difference was found regarding ORR. The median follow-up was 27.7 months (95%CI: 24.7&ndash, 34.4). Aflibercept-treated group had a significantly shorter PFS compared to Bevacizumab-treated group (5.6 vs. 7.1 months, respectively) (HR = 1.34 (95%CI: 0.95&ndash, 1.89), p = 0.0932). The median OS of the Bevacizumab-treated group and Aflibercept-treated group was 16.2 (95%CI: 15.3&ndash, 18.1) and 12.7 (95%CI: 8.8&ndash, 17.5) months, respectively (HR= 1.31 (95%CI: 0.89&ndash, 1.93) p = 0.16). After adjusting for the key covariates (age, gender, performance status, number of metastatic sites and primary tumor side) Bevacizumab-based regimens revealed to be significantly related with a prolonged PFS (HR = 1.44 (95%CI: 1.02&ndash, 2.03), p = 0.0399) compared to Aflibercept-based regimens, but not with a prolonged OS (HR = 1.47 (95%CI: 0.99&ndash, 2.17), p = 0.0503). The incidence of G3/G4 VEGF inhibitors class-specific AEs was 7.5% and 26.5% in the Bevacizumab-treated group and the Aflibercept-treated group, respectively (p = 0.0001). Conclusion: Our analysis seems to reveal that Bevacizumab-based regimens have a slightly better PFS and class-specific AEs profile compared to Aflibercept-based regimen as second-line treatment of RAS wild-type mCRC patients previously treated with anti-EGFR based treatments. These results have to be taken with caution and no conclusive considerations are allowed.

In this paper, we address the question of how specific barman/robot interaction styles can affect users' engagement. To this extent, we implemented a barman-robot called "BRILLO" with neutral, entertaining, and emphatic behavioral style suggesting drinks and taking orders from customers. Results show that a robot's interaction style may determine users' level of engagement. Indeed, interacting with an emphatic robot that modulates its behavior according to the user's one is more effective than a neutral robot in improving engagement and positive emotions in public-service contexts. Moreover, users experienced more positive emotions when they perceived BRILLO as safe and as more similar to a human.

The rehabilitation intervention in children with motor or cognitive impairments requires to be effectively measured in terms of\ud engagement to understand the effects of the rehabilitation process\ud and to enable more targeted interventions leading to improved\ud experiences for both children and rehabilitation therapists. Indeed,\ud the rehabilitation practice may be enhanced by attending to the\ud client’s signals of engagement in therapy. In this paper, we present\ud the results of the validation of the PARE scale (Pediatric Assessment\ud of Rehabilitation Engagement) that was designed to capture the\ud dimensions of affective, cognitive, and behavioral engagement in\ud the interaction of clients-rehabilitation providers. Results showed\ud that the scale can be effectively used for the measurement of the\ud different components of engagement in intervention settings to\ud support therapeutic virtual scenarios or the application of robots\ud to treat motor and cognitive impairments.

Socially assistive robots might improve the quality of life of individuals by carrying out therapeutic interventions. However, when users try to cheat with robots by disregarding their recommendations, they might not be able to perform their supporting functions. In the present study, we aimed to evaluate how the robot behavior style could affect the users' compliance and cheating behavior. Sixty volunteers underwent neuro-psychological testing administered by Pepper that was configured as neutral, friendly, or authoritarian. The results revealed that the robot characterized by neutral behavioral style seems to reduce individuals' compliance.

Role play simulation games have recently received attention in the training and education fields as a mechanism for providing generative and creative learning. E-learning systems can provide a solid platform upon which role play simulation can be created and implemented to promote both knowledge and competence development. This form of active learning provides a unique tool for training people in different context of applications which may be able to benefit from the availability of open source e-learning tools and overcome lack of access to affordable training and developmental resources. In this paper it will be described the approach and the methodology used to develop a digital single player role play game, named ACCORD, so to provide a new e-learning and flexible tool, to help teachers and educators to autonomously improve and assess their intercultural competencies within the school context.

Purpose: BRAF mutations represent the main negative prognostic factor for metastatic colorectal cancer and a supposed negative predictive factor of response to standard chemotherapy. We have explored survival difference in right-sided colon cancer (RCC) patients according to BRAF mutations, with the aim to identify any predictive factors of response to targeted-based therapy. Methods: A retrospective study of RCC patients, with BRAF known mutation status, treated with chemotherapy (CT) from October 2008 to June 2019 in 5 Italian centers, was conducted. Results: We identified 207 advanced RCC patients: 20.3% BRAF mutant and 79.7% BRAF wild type (wt). BRAF-mutant cancers were more likely to be pT4 (50.0% v 25.7%, p = 0.016), undifferentiated (71.4% v 44.0%, p = 0.004), KRAS wt (90.5% v 38.2%, p < 0.001), and MSI-H (41.7% v 16.2%, p = 0.019) tumors, with synchronous (52.4% v 31.5%, p = 0.018) and peritoneal metastases (38.1% v 22.4%, p = 0.003). Median overall survival (OS) was 16 v 27months in BRAF mutant and BRAF wt (P = 0.020). In first-line setting, BRAF-mutant showed a 2ys OS of 80% in clinical trials, 32% in anti-VEGF, 14% in epidermial growth factor receptor (EGFR), and 0% in chemotherapy alone regimens (P = 0.009). BRAF-mutant patients demonstrated worse survival, regardless of targeted therapy administered. However, survival difference was statistically significant in the anti-EGFR-treated subgroup (16 v 28months, P = 0.005 in BRAF mutant v BRAF wt, respectively). Conclusions: Our study demonstrated that BRAF status makes the difference in treatment’s outcome. Therefore, the anti-EGFR should not be excluded in all advanced RCC but considered on a case-by-case basis.

The use of serious games to support learning continues to expand across a range of educational and training settings. Hence, a need exists to understand more fully how users experience such games. This study seeks to describe and assess an approach to the evaluation of user-experience applied within the context of a specific serious game developed to address the training needs of people working in social enterprises. Drawing on an extensive literature review, the development of a survey instrument to capture the multi-dimensional nature of user-experience is explained as is the evaluation process employed. Findings from surveys of individuals working in social enterprises are analysed and discussed. The results demonstrate the value of the proposed method of user-experience evaluation. Recommendations for practice and further research are outlined, identifying in particular the importance of qualitative insights in the evaluation process and the need for greater understanding of the inter-relationships between the various dimensions and attributes of user-experience in serious games.

Purpose There is no consensus on the use of cetuximab in elderly patients with metastatic colorectal cancer. To this end, a survey was carried in 17 Italian oncology centers. Methods The centers answered a 29-item questionnaire structured as follows: (i) demographic characteristics; (ii) medical history; (iii) assessment of RAS/BRAF mutations and DPD/UGT polymorphism before treatment; (iv) treatment schemes and side effects; (v) geriatric assessment and customization of treatment. Results One-third of patients are over 80 years old. The RAS/BRAF mutational status is not primarily evaluated by 17.6% of the centers, while DPD and UGT polymorphism is not evaluated by 82.4% and 76.5% of the centers. The most common therapeutic scheme is cetuximab/FOLFIRI and diarrhea is the main cause of suspension/reduction of treatment. The 70% of centers use systemic tetracyclines for skin toxicity. The 23.5% of the centers do not carry out any geriatric evaluation before the start of the therapy and those who perform it prefer the G8 (70.6%) and VES-13 (29.4%) scales. Conclusions Greater efforts should be made to improve the evaluation of the patient both about mutational and genetic procedures with geriatric evaluation. As for cetuximab in elderly patients, randomized studies are needed to provide guidance to physicians.

Scenario-based learning (SBL) has recently received more and more attention in the training and education fields as a mechanism for providing active and generative learning. E-learning systems can provide a solid platform upon which SBL can be created and used to promote relational competences development, and to offer open source e-learning tools so to overcome common lack of access to affordable training resources. Within this paper a project called ACCORD to develop a new e-learning system to promote intercultural skills in terms of intercultural literacy, inclusive education and conflict management will be described. This project aims to prepare secondary school teachers from five European countries (Austria, Belgium, Germany, Italy, Spain) to take an active stand against intercultural conflicts within the school context, by providing SBL and game-based learning approach. The present article will provide an overview of the ACCORD project, highlighting the theoretical framework underpinning its development, the methodologies that have been used, and the main preliminary outcomes.

Social Assistive Robots are starting to be widely used in paediatric health-care environments. In this domain, the development of effective strategies to keep the children engaged during the interaction with a social robot is still an open research area. On this subject, some approaches are investigating the combination of distraction strategies, as used in human-human interaction, and the display of emotional behaviours. In this study, we presented the results of a pilot study aimed to evaluate with children the valence of emotional behaviours enhanced with non-verbal sounds. The objective is to endow the NAO robot with emotional-like sounds, selected from a set of para-linguistic behaviours validated by valence. Results show that children aged 3–8 years perceive the robot’s behaviours and the related selected emotional semantic free sounds in terms of different degrees of arousal, valence and dominance: while valence and dominance are clearly perceived by the children, arousal is more difficult to distinguish.

Cetuximab is a chimeric monoclonal antibody that has revolutionized the treatment of metastatic colorectal cancer. Knowledge of the mechanisms that underlie its effectiveness, as well as the primary and secondary resistance mechanisms, have led to important developments in the understanding of cetuximab biology. In light of knowledge gained from recent trials, the efficacy of cetuximab has been clearly demonstrated to depend upon RAS mutational status, moreover cetuximab should only be used in a subset of patients who may benefit. In this article, we critically review clinical and pharmacogenetic issues of cetuximab, focusing on the cost–effectiveness involved with the use of the drug.

In recent years, the ever-increasing need for valid and effective training to acquire competences in multiform contexts has led to a wide diffusion of educational games (EG). In spite of their diffusion, there is still a need to reflect on the design process that should embed the games&rsquo, pedagogical potential and the instructional process in the entertainment scope. Moreover, as building EG, especially in digital environments, is an enterprise that involves specialists with different expertise, it can be useful to have a shared methodology that is easily understandable and usable by many users. In this paper, we propose to use situated psychological agents (SPA) as a methodology to design and build effective EG and show how to represent games in terms of SPA and their interactions by diagrams and describe different examples of how this approach has been applied.

Tumour-associated Macrophages (TAM) present two different polarizations: classical (M1) characterized by immunostimulation activity and tumour suppression; alternative (M2) characterized by tumour promotion and immune suppression. In this retrospective study, we evaluated the correlation between the two forms of TAM with survival time in radically resected gastric cancer patients. A total of 52 chemo- and radio- naive patients were included. Two slides were prepared for each patient and double-stained for CD68/NOS2 (M1) or CD68/CD163 (M2) and five representative high-power fields per slide were evaluated for TAM count. The median value of the two macrophage populations density and the median value of M1/M2 ratio were used as cut-off. Twenty-seven patients with M1 density above-the-median had a significantly higher survival compared to those below the median. Twenty-six patients with M1/M2 ratio above the median showed median OS of 27.2 months compared to 15.5 months of the patients below the median. No association between M2 macrophage density and patient’s outcome was found. In multivariate analysis, M1/M2 was a positive independent predictor of survival. The M1 macrophage density and M1/M2 ratio, as con- firmed in multivariate analysis, are factors that can help in predicting patients survival time after radical surgery for gastric cancer.

International audience; A new hybrid microwave (MW) and ultrasound (US)-assisted reactor concept was investigated. The 2.45 GHz microwaves were delivered by a semiconductor generator via a coaxial cable to a monomode Transverse Electric (TE) microwave resonant cavity within which the reactor was placed; the US (25 kHz) were delivered at the bottom of the TE cavity via a novel designed sonotrode consisting of a detachable metallic plate-probe (indirect sonication). The semiconductor microwave generator helped to optimize the absorbed energy via its automatic frequency tuning function. The dual MW/US device allowed the use of both technologies separately or in a simultaneous combined manner. The ring-closing metathesis of diethyl diallyl malonate in glycerol micellar conditions was studied as an example using this novel hybrid technology. The results were compared with those obtained when microwaves or ultrasound were applied individually. Various benzylidene-, indenylidene- and Hoveyda–Grubbs-type catalysts were screened. The novel reactor for combined MW/US irradiation showed beneficial effects on the outcome of the reaction.

Background: To assess the predictive role of lactate dehydrogenases (LDH) and fibrinogen (FBG) serum levels in metastatic colorectal cancer (mCRC) patients receiving a first-line bevacizumab-based therapy.Objectives: The aim of the present analysis was to retrospectively evaluate the role of basal and post-treatment LDH and FBG serum levels in predicting the clinical outcome of 139 mCRC patients receiving first-line chemotherapy in combination with bevacizumab.Results: A statistically significant association between high pre-treatment LDH and FBG levels and progressive disease was observed with respect to low basal LDH and FBG patients. Furthermore, median progression-free survival was 7.3 versus 10.8 months and 7.3 versus 9.4 months for high and low LDH and FBG levels, respectively. Within the high LDH group, we observed a statistically significant reduction of LDH mean value compared with pre-treatment values in patients with objective response rate and stable disease.Conclusions: High LDH and FBG levels correlated with prognosis. A significant correlation between bevacizumab-based chemotherapy-induced reduction in LDH serum levels and response to treatment was observed within the high LDH group. These results, if confirmed in larger prospective studies, could be helpful for early identification of patients responsive to bevacizumab-based chemotherapy or candidate to more aggressive treatments.

International audience; The syntheses of ten novel mono-, di- or tri-cationic poly(ethylene glycol)-based ionic liquids (ILPEGs), incorporating tetra-substituted ammonium cations, are described. The poly(ethylene glycol) chains could be bridged or not and bore the cation. In the di-cationic ILPEG family, hydrophobic poly(methylene) or amphipathic poly(oxyethylene) spacers, with various lengths, were designed to connect the polar heads, while in the tri-cationic ILPEG family, the spacer was constituted by substituted diamines. The thermophysical properties such as viscosity or thermal stability were also investigated.

International audience; : PEG-based ionic liquids are a new appealing group of solvents making the link between two distinct but very similar fluids: ionic liquids and poly(ethylene glycol)s. They find applications across a range of innumerable disciplines in science, technology, and engineering. In the last years, the possibility to use these as alternative solvents for organic synthesis and catalysis has been increasingly explored. This Review highlights strategies for their synthesis, their physical properties (critical point, glass transition temperature, density, rheological properties), and their application in reactions catalyzed by metals (such as Pd, Cu, W, or Rh) or as organic solvent (for example for multicomponent reactions, organocatalysis, CO2 transformation) with special emphasis on their toxicity, environmental impact, and biodegradability. These aspects, very often neglected, need to be considered in addition to the green criteria usually considered to establish ecofriendly processes.

Stando alle dichiarazioni di Leonardo Sinisgalli, la sua ricerca intellettuale ed esistenziale sarebbe passata dall'ascetismo pitagorico del numero e della geometria all'abbandono definitivo della «cittadella del sublime» rappresentata dagli studi della matematica e dell'ingegneria, abbandonata a favore dei «primi versi “en plein air”». Il saggio si propone invece di mostrare che nella speculazione di Sinisgalli non si è affatto instaurato un dualismo tra scienza e letteratura vissuto secondo questi asseriti rapporti di esclusione reciproca. Al contrario, prendendo alla lettera la sua dichiarazione secondo cui «il poeta è portato necessariamente a contraddirsi, a rinnegarsi, a distruggersi», la sua poetica, lungi dal coltivare idee giustapposte senza metodo, si fonda in realtà su una feconda dialettica tra letteratura e scienza che si esprime con la logica inclusiva dell'ossimoro.

PURPOSE: The miRNA-regulating enzymes Dicer and Drosha exhibit aberrant expression in several cancer types. Dicer and Drosha play a crucial role during the angiogenetic process in vitro and, for Dicer, in vivo. We aimed to investigate the potential role of Dicer and Drosha in predicting response to Bevacizumab-based therapy in advanced colorectal cancer (CRC) patients. METHODS: Dicer and Drosha mRNA levels were analysed in formalin-fixed paraffin-embedded specimens from patients affected by advanced CRC treated with or without Bevacizumab-containing regimens (n=116 and n=50, respectively) and from patients with diverticulosis as control group (n=20). The experimental data were obtained using qRT-PCR, analysed comparing Dicer and Drosha expression levels in tumour samples versus normal mucosa and then compared to clinical outcome. RESULTS: The tumour samples from Bevacizumab-treated patients showed a significantly higher Drosha expression (P

Several clinical series have demonstrated a notably low overall survival for colorectal cancer patients diagnosed with a BRAF-mutant tumor. A potentially interesting predictive role has also been suggested for BRAF-mutant colorectal cancer receiving anti-EGFR monoclonal antibodies. Although a global consensus exists in indicating BRAF as a prognostic factor with a possible predictive activity, the clinical use of BRAF mutational status in colorectal tumors is still controversial. This article reviews the current knowledge on the use and implications of BRAF mutational status in colorectal tumors, in order to define its present role in the clinical practice. Also suggested are possible treatment strategies in this prognostically challenging group of patients. Finally, a comprehensive outlook on future developments for specifically directed anti-BRAF therapy is illustrated.