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65. A p53-CBP/p300 transcription module is required for GAP-43 expression, axon outgrowth, and regeneration.

Author

Tedeschi, A., Nguyen, T., Puttagunta, R., Gaub, P., and Di Giovanni, S.

Subjects
P53 protein, NERVOUS system regeneration, AXONS, GENETIC transcription regulation, ACETYLTRANSFERASES
Abstract

Transcription regulates axon outgrowth and regeneration. However, to date, no transcription complexes have been shown to control axon outgrowth and regeneration by regulating axon growth genes. Here, we report that the tumor suppressor p53 and its acetyltransferases CBP/p300 form a transcriptional complex that regulates the axonal growth-associated protein 43, a well-characterized pro-axon outgrowth and regeneration protein. Acetylated p53 at K372-3-82 drives axon outgrowth, GAP-43 expression, and binds specific elements on the neuronal GAP-43 promoter in a chromatin environment through CBP/p300 signaling. Importantly, in an axon regeneration model, both CBP and p53 K372-3-82 are induced following axotomy in facial motor neurons, where p53 K372-3-82 occupancy of GAP-43 promoter is enhanced as shown by in vivo chromatin immunoprecipitation. Finally, by comparing wild-type and p53 null mice, we demonstrate that the p53/GAP-43 transcriptional module is specifically switched on during axon regeneration in vivo. These data contribute to the understanding of gene regulation in axon outgrowth and may suggest new molecular targets for axon regeneration.Cell Death and Differentiation (2009) 16, 543–554; doi:10.1038/cdd.2008.175; published online 5 December 2008 [ABSTRACT FROM AUTHOR]

Published
2009
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69. Coenzyme Q10reverses pathological phenotype and reduces apoptosis in familial CoQ10deficiency

Author

Di Giovanni, S., Mirabella, M., Spinazzola, A., Crociani, P., Silvestri, G., Broccolini, A., Tonali, P., Di Mauro, S., and Servidei, S.

Abstract

Two brothers with myopathic coenzyme Q10(CoQ10) deficiency responded dramatically to CoQ10supplementation. Muscle biopsies before therapy showed ragged-red fibers, lipid storage, and complex I III and II III deficiency. Approximately 30 of myofibers had multiple features of apoptosis. After 8 months of treatment, excessive lipid storage resolved, CoQ10level normalized, mitochondrial enzymes increased, and proportion of fibers with TUNEL-positive nuclei decreased to 10. The authors conclude that muscle CoQ10deficiency can be corrected by supplementation of CoQ10, which appears to stimulate mitochondrial proliferation and to prevent apoptosis.

Published
2001

70. Effect of Protein/Energy Balance in Diets for Buffalo Herds on Milk Yield and Nitrogen Excretion.

Author

Pace, V., Grani, D., Carfì, F., Contò, G., Di Giovanni, S., Terzano, G. M., and Terramoccia, S.

Subjects
PROTEIN content of food, BIOENERGETICS, MILK yield, COMPOSITION of milk, HERDING, ENERGY metabolism, NITROGEN excretion, LACTATION
Abstract

The protein and energy content of diets administered to lactating buffaloes and milk performance traits were analysed in 90 Italian herds to optimize the ingested/excreted nitrogen ratio. The considered parameters were: dry matter (DM) intake, crude protein (CP) and net energy (NE) level of the diets, milk yield and composition (protein and fat). In each herd, the differences (?CP or ?NE) between crude protein or net energy content of the administered diets and the requirements, on the basis of the daily milk production, were assumed as the index of the balance of the diets. So threshold values of CP and NE required for milk production were established and the herds were divided into three groups either according to the estimated ?CP: group 1 (lack of protein), group 2 (balanced), group 3 (excess) or according to the estimated ?NE: group 1 (lack of energy), group 2 (balanced), group 3 (excess). A CP excess in the diet (group 3) did not improve the normalized milk yield (8.09 vs 8.06 kg/d) in respect to the herds of group 2, whereas the normalized milk yield of group 1 (7.36 kg/d) was statistically different (P<0.10) from the other two groups. As far as NE balance was concerned, both lack and excess significantly reduced normalized milk yield, with respect to balanced diets (7.02, 7.34 vs 8.72 kg/d, P<0.05). [ABSTRACT FROM AUTHOR]

Published
2010

71. Down-regulation of cell-surface CD4 co-receptor expression and modulation of experimental allergic encephalomyelitis.

Author

Fiori, P, Ristori, G, Cacciani, A, Buttinelli, C, Falcone, M, Di Giovanni, S, Montesperelli, C, Pozzilli, C, and Salvetti, M

Abstract

Pre-immunization with autoantigens confers resistance in experimental models of autoimmune diseases. Since non-self molecules can also be protective, it is conceivable that part of the effect rests on a non-specific attenuation of the immune response. This study is aimed at identifying mechanisms by which pre-immunization with a moiety suspended in incomplete Freund's adjuvant (IFA) protects from experimental allergic encephalomyelitis (EAE). Lewis rats were immunized with each of either concanavalin A, lipopolysaccharide, bovine serum albumin, 70 or 65 kDa heat shock proteins, or myelin basic protein. All moieties were given in IFA 3 weeks prior to EAE induction. Serial cytofluorimetric monitoring of B cells and of the alpha beta TCR+, CD4+, CD8+, CD45high and CD45low cells was performed. IFN-gamma and IgG1 production was evaluated in parallel. All moieties were able to attenuate or abrogate the clinical signs of EAE. At day 4 and 10 after EAE induction, the surface expression of the CD4 molecule was down-regulated on T lymphocytes. This down-regulation was most evident in animals with the highest degree of clinical protection. By day 21 post-immunization, CD4 expression was restored. The same animals also showed an increase in the B cell percentage and Th2-related IgG1 production while IFN-gamma secretion was reduced. Pre-immunization with diverse antigens suspended in IFA confers resistance to EAE induction. The down-regulation of the CD4 co-receptor accompanied by events suggestive of an immune deviation may be a general mechanism that contributes to the protection.

Published
1997
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72. Surgical complications in prophylactic central neck dissection: Preliminary findings from a retrospective cohort study

Author

Scerrino, G., Di Giovanni, S., Salamone, G., Melfa, I., Inviati, A., Raspanti, C., Gaspare Gulotta, Scerrino, G., Di Giovanni, S., Salamone, G., Melfa, I., Inviati, A., Raspanti, C., and Gulotta, G.

Subjects
Settore MED/18 - Chirurgia Generale, Hypoparathyroidism, Vocal cord paralysis, Papillary, Thyroidectomy, Thyroid cancer
Abstract

Aim. Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignancy with an overall ten-year survival more than 90%. Total thyroidectomy (TT) is considered the gold standard for PTC, but not all the endocrine surgeons agree on central neck dissection except in case of known metastases. Methods. We enrolled 158 patients, that underwent, between January 1990 and September 2012 total thyroidectomy±prophylactic CND for PTC. 59 Patients (group A) had a preoperative diagnosis of PTC; 99 (group B) had a diagnosis of benign disease. We focused on possible complications. Results. In group A we had 4 patients who blamed a definitive RLN palsy, only 1 patient in group B, with an OR=7.12. Definitive hypoparathyroidism was found respectively in 3 patients of group A and in 5 patients in group B, even in this case not statistically significant with an OR=1.007. Conclusion. We can affirm that the complications of thyroid surgery seem not to be strongly associated to the extent of surgery.

73. A 3D totally absorbable synthetic mesh in antireflux surgery: Gore Bio-A tissue reinforcement for hiatal hernia repairing

Author

Agrusa, A., Romano, G., Frazzetta, G., Inviati, A., Vita, G., Di Giovanni, S., Chianetta, D., Di Buono, G., Bonventre, S., Gaspare Gulotta, Agrusa, A, Romano, G, Frazzetta, G, Inviati, A, De Vita, G, Di Giovanni, S, Chianetta, D, Di Buono, G, Bonventre, S, and Gulotta, G

Subjects
Settore MED/18 - Chirurgia Generale, laparoscopic surgery, antireflux surgery
Abstract

Introduction Hiatal hernia, defined as “transitory or stable dislocation of a part of the stomach in mediastinum through the diaphragmatic crura delimiting esophageal hiatus”. Its appearance presupposes anatomic anomalies or weakening of structures and mechanisms able to maintain esophago-gastric junction and stomach in the abdominal cavity [1]. Classically hiatal hernia was classified in four types using Hill’s classification: Type 1 hiatal hernia is associated with GERD in 50-90% of cases, in facts its presence gradually compromises esophago-gastric junction’s continence favouriting the backwater of acid secretion and its reflux in contact with esophageal mucosa during transient relaxations of the LES and also reducing clearing systems overall for large hiatal hernias [2, 3]. Several randomized controlled trials with long-term follow-up comparing surgical with medical therapy for the treatment of GERD, strongly support surgery as an effective alternative to medical therapy [4]. Fundoplication has also been demonstrated to lead to improved or at least comparable quality of life to that of medically treated patients and it is associated with high patients satisfactions rate [5]. A laparoscopic total fundoplication is considered today the procedure of choice increasing the resting pressure and length of the lower esophageal sphincter, decreasing the number of transient LES relaxations and improving quality of esophageal peristalsis and follow-up demonstrates complete symptoms control in 80-90% of patients 10 years later [6]. However primary laparoscopic hiatal hernia repair is associated with up 42% recurrence rate [7]. Several level data suggest that mesh reinforcement of the crural closure for hiatal hernia repair decreases the recurrence of hernia, but can lead to esophageal erosion and stenosis or disphagya, above all non-absorbable mesh [8, 9]. For this clinical case, we experiment a new totally absorbable Gore Bio-A® mesh [10]. Materials and methods: Clinical Case Female patient; 65-year old; 6-year classic history of GERD (regurgitation, belching, bloating, “acid in the throat” treated for several years by multiple proton pump inhibitors); BMI 22. An EGDS revealed a > 3 cm hiatal hernia, grade B Los Angeles esophagitis. 24-hour pH study was positive for acid reflux and esophageal manometry revealed LES intrathoracic dislocation. With laparoscopic 5-trocars approach, the hiatal hernia defect was identified and primarily repaired, by crural closure, with size 0 permanent suture (ETHIBOND). GORE BIO-A® Tissue Reinforcement was trimmed to fit the defect with a “U” shape cutout to accommodate the esophagus. It was secured using two absorbable sutures (VICYRL). At least A Nissen fundoplication was performed without incident. Result: Gore BIO-A® mesh was easily placed through a 10-12 mm trocar. It had good handling characteristics laparoscopically, and no pre-operative preparation was required of the prosthetic. It can be cut and tailored intraoperatively to an optimal adaptation. There were no short-term complications from the mesh. The patient had not significant post-operative sequelae. Conclusion Crural closure reinforcement during hiatal hernia repair can be done readily with this new totally absorbable Gore Bio A Tissue Reinforcement: it is a 3D web of completely absorbable synthetic polymers replaced by soft tissue over six months; it is a mix of glycolic acid and trimethylene carbonate and its function consistes in stimulating collagens deposition and ingrowth of new connective soft tissue [11]. It was demonstrated that Gore Bio-A increases cellular in-growth in 7-30 days more and more previously than biologics mesh; it also increases new blood vessels formation in 7-14 days reaching the greatest vascular in-growth. Instead the biologic meshes gore BIO-A seems to induce the least inflammatory infiltrate. Gore BIO-A tissue reinforcement seems to have all the best characteristics to hernia hiatal laparoscopic repair reducing both recurrence rates and post-operative mesh-related complications, even if several other cases and studies are necessary. However further data and studies are needed to evaluate long-term efficacy and complications associated with its use.

74. Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: Results from a high-prevalence area

Author

Scerrino, G., Attard, A., Melfa, G. I., Raspanti, C., Di Giovanni, S., Attard, M., Inviati, A., Mazzola, S., Modica, G., Gulotta, G., Sebastiano BONVENTRE, Scerrino, G., Attard, A., Melfa, G., Raspanti, C., Di Giovanni, S., Attard, M., Inviati, A., Mazzola, S., Modica, G., Gulotta, G., and Bonventre, S

Subjects
Settore MED/18 - Chirurgia Generale, Recurrence, Papillary, Thyroidectomy, Surgery, Neck dissection, Therapeutic, Therapeutics, Thyroid cancer
Abstract

BACKGROUND: Prophylactic, compartment-oriented central neck dissection (CND) for cN0 papillary thyroid carcinoma (PTC) is not widely practiced. We examined our results with this surgical approach. METHODS: A cohort of 158 patients operated on for the classical variant of PTC at a follow-up of 1-22 years (mean: 6.6) were enrolled. The patients with a preoperative diagnosis of cN0 PTC (group A, 59 patients) underwent total thyroidectomy (TT) + CND. In the patients with incidental postoperative diagnosis of malignancy (group B, 99 patients) a TT alone was performed. RESULTS: Ninety-six T1, 36 T2, 26 T3/T4 PTC patients were enrolled. The overall biochemical/scintigraphic recurrence rate (15 patients, 9.49%), was significantly higher in group B. Disease-free survival and need for postoperative radioiodine ablative treatment were more favorable in group A (P

86. Hiatal Hernia Repair with Gore Bio-A Tissue Reinforcement: Our Experience

Author

Agrusa Antonino, Romano Giorgio, Frazzetta Giuseppe, De Vita Giovanni, Di Giovanni Silvia, Chianetta Daniela, Di Buono Giuseppe, Sorce Vincenzo, and Gulotta Gaspare

Subjects
Surgery, RD1-811
Abstract

Type I hiatal hernia is associated with gastroesophageal reflux disease (GERD) in 50–90% of cases. Several trials strongly support surgery as an effective alternative to medical therapy. Today, laparoscopic fundoplication is considered as the procedure of choice. However, primary laparoscopic hiatal hernia repair is associated with upto 42% recurrence rate. Mesh reinforcement of the crural closure decreases the recurrence but can lead to complications, above all nonabsorbable ones. We experiment a new totally absorbable mesh by Gore. Case. We present a case of a 65-year-old female patient with a 6-year classic history of GERD. Endoscopy revealed a large hiatal hernia and esophagitis. pH study was positive for acid reflux; esophageal manometry revealed LES intrathoracic dislocation. With laparoscopic approach, the hiatal hernia defect was identified and primarily repaired, by crural closure. Gore Bio-A Tissue Reinforcement was trimmed to fit the defect accommodating the esophagus. Nissen fundoplication was performed. Result. Bio-A mesh was easily placed laparoscopically. It has good handling and could be cut and tailored intraoperatively for optimal adaptation. There were no short-term complications. Conclusion. Crural closure reinforcement can be done readily with this new totally absorbable mesh replaced by soft tissue over six months. However, further data and studies are needed to evaluate long-term outcomes.

Published
2014
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87. A 3D totally absorbable synthetic mesh in antireflux surgery: Gore Bio-A tissue reinforcement for hiatal hernia repairing.

Author

Agrusa, A., Romano, G., Frazzetta, G., Inviati, A., De Vita, G., Di Giovanni, S., Chianetta, D., Di Buono, G., Bonventre, S., and Gulotta, G.

Subjects
GASTROESOPHAGEAL reflux, PROTON pump inhibitors, DIGESTIVE system endoscopic surgery, HIATAL hernia, SURGERY, DISEASES
Abstract

The article presents a case study of a 65-year old female with gastroesophageal reflux disease (GERD) treated for several years by multiple proton pump inhibitors. Topics mentioned include the esophagogastroduodenoscopy (EGDS) performed to her which revealed a hiatal hernia, the safety measures for surgical operation, and the crural closure reinforcement during the hiatal hernia repair.

Published
2015

88. Multi-detector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the evaluation of the mandibular invasion by squamous cell carcinomas (SCC) of the oral cavity. Correlation with pathological data

Author

Di Giovanni Salvatore, Guerrisi Isabella, Mattioni Oreste, Covello Renato, Manciocco Valentina, Pellini Raul, Guerrisi Antonino, Vidiri Antonello, Spriano Giuseppe, and Crecco Marcello

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To retrospectively compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multidetector-row computed tomography (MDCT) in the assessment of the mandibular invasion by squamous cell carcinoma (SCC) having histopathological exams as standard of reference. Materials and methods Institutional review board approval with a waiver of informed patient consent was obtained. Of the 147 patients selected from our database who underwent surgical excision of a tumour arising into the oral cavity, thirty-six patients (26 men, 10 women; mean age, 56 years; range, 30-75 years) with hystologically proven SCC who performed both a preoperative MRI and MDCT, composed our final study population. Images were qualitatively analyzed in consensus by two expert radiologist in head and neck imaging. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were assessed for both MRI and MDCT. Differences in sensitivity, specificity, positive and negative predictive values were calculated at a statistical significance of p < .05. Results The sensitivity, the specificity and the accuracy of MRI and MDCT in the detection of the mandibular involvement were respectively 93%, 82%, 86% and 79%, 82%, 81%, while the positive predictive value (PPV) and negative predictive value (NPV) were respectively 76%, 95% and 73%, 86%. There wasn't any statistically significant difference in overall diagnostic accuracy between MRI and MDCT in the evaluation of mandibular tumour invasion (p > .05). Conclusion MRI showed to have a higher sensitivity compare to MDCT in the assessment of mandibular involvement from SCC arising in the oral cavity although none statistically significant differences were noted.

Published
2010
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89. CHEMICAL AND MICROBIOLOGICAL CHARACTERISTICS OF HOMOGENISED RICOTTA CHEESE PRODUCED FROM BUFFALO WHEY.

Author

TRIPALDI, C., RINALDI, S., PALOCCI, G., DI GIOVANNI, S., CAMPAGNA, M. C., DI RUSSO, C., and ZOTTOLA, T.

Subjects
*CHEESE varieties, *WHEY, *CHEESE, *LONGEVITY, *REDUCTION potential, *HEAT treatment
Abstract

To extend the shelf life of buffalo Ricotta cheese, a process was assessed that included a second heat treatment followed by homogenisation and hot packaging. The microbiological and chemical characteristics as well as the oxidation degree of the product were determined over storage for 21 days using total antioxidant activity, redox potential, malondialdehyde content, and protein-bound carbonyl content. Homogenised buffalo Ricotta cheese has a longer shelf life than traditional Ricotta cheese, although the process could be optimised to reduce the total bacterial load during storage. No significant oxidative damage occurred during storage. This innovative process could promote the market expansion of Ricotta cheese. [ABSTRACT FROM AUTHOR]

Published
2020

90. Evolving Trends in the Management of Acute Appendicitis During COVID-19 Waves: The ACIE Appy II Study

Author

Pata, Francesco, Di Martino, Marcello, Podda, Mauro, Di Saverio, Salomone, Ielpo, Benedetto, Pellino, Gianluca, Julio, Abba, Alshamrani, Abdullah, Alturkistani, Abdullah, Alghamdi, Abdulrahman, Almalki, Abdulrahman, Orengia, Adam, Kuvvetli, Adnan, Pisanu, Adolfo, Smith, Adrian, Treviño Figueroa, Adriana Michelle, Nacion, Aeris Jane, Alhazmi, Ahmad, Bouhuwaish, Ahmad, Khalid, Ahmad, Alsufyani, Ahmed, Rubio, Ainhoa Valle, Bavikatte, Akshay, Kumar, Akshay, Jamiri, Al-Radjid, de San Ildefonso Pereira, Alberto, Porcu, Alberto, Sartori, Alberto, Rocca, Aldo, Sretenovic, Aleksandar, Anselmo, Alessandro, De Luca, Alessandro, Charalabopoulos, Alexandros, Tzivanakis, Alexios, Bandin, Alfonso, Nájar, Alfonso, Frontali, Alice, Faisal, Alsulaimani, Roldan, Amaia Martínez, Hamid, Amal, André, Ana, Minaya-Bravo, Ana, Das, Andre, Bondurri, Andrea, Costanzi, Andrea, Lucchi, Andrea, Mihailescu, Andrei, Police, Andrea, Zuchini, Andres Mendoza, Romano, Angela, Iossa, Angelo, Chessa, Antonella, Tromba, Antonella, Castaldi, Antonio, Brillantino, Antonio, Ferronetti, Antonio, Giuliani, Antonio, Ramos-De la Medina, Antonio, Tarasconi, Antonio, Picciariello, Arcangelo, Ioannidis, Argyrios, Leppäniemi, Ari, Rashid, Arshad, Mitul, Ashrarur Rahman, Mehraj, Asif, Laharwal, Asim, Iqbal, Atif, Liarakos, Athanasios, Marinis, Athanasios, de Andrés-Asenjo, Beatriz, Matías-García, Belén, De Simone, Belinda, Creavin, Ben, Stubbs, Ben, Goh, Brian, Jovanovic, Branislav, Sensi, Bruno, Gazia, Carlo, Cerdán, Carlos, Díaz, Carlos Javier Gómez, Chacón, Carlos Petrola, Yánez, Carlos, Faro, Carmelo Lo, Reinke, Caroline, Dominguez, Casandra, Paranjape, Charudutt, Thomas, Charlotte, Fung, Chia Chi, De Lucia, Chiara, Jennifer, Chiu Hiu Fung, Ovalle-Chao, Christian, Guerci, Claudio, Kenington, Cleo, Gica, Corina, Folliero, Cristina, Varela, Cristopher, Popowich, Daniel, Delogu, Daniele, Zigiotto, Daniele, Vinci, Danilo, D’Antonio, Dario, Merlini, David Alessio, Merlini, David, Moro-Valdezate, David, Keller, Deborah, Nicolaescu, Diana Cristiana, Sasia, Diego, Rodas, Edgar, Linardoutsos, Dimitrios, Russello, Domenico, Nájar-Castañeda, Pedro Alfonso, Stavrou, Habil Gregor, Rosso, Edoardo, Saladino, Edoardo, Ricciardi, Edoardo, Smith-Singares, Eduardo, Baili, Efstratia, Douka, Eleftheria, Guaitoli, Eleonora, Francone, Elisa, Vaterlini, Elisa Maria, Pierobon, Elisa Sefora, Morales, Emilio, Ros, Emilio Peña, Benzoni, Enrico, Erdas, Enrico, Pinotti, Enrico, Colás-Ruiz, Enrique, Laterza, Ernesto, Foianini, Esteban, Cardamone, Eugenia, Licardie, Eugenio, Marino, Fabio, Alsofyani, Fahad, Qahtani, Fahad, Khan, Farhan, Maraska, Fatlum, Saliu, Fatmir, Madrid, Fausto, Rosa, Fausto, Luvisetto, Federico, Alconchel, Felipe, Pareja-Ciuro, Felipe, Neves, Fernanda, Agresta, Ferdinando, Cordera, Fernando, Pardo, Fernando, Mendoza-Moreno, Fernando, Munoz-Flores, Fernando, Silvestri, Francesca Maria, Tropeano, Francesca Paola, Pecchini, Francesca, Serio, Francesca, Colombo, Francesco, Di Marzo, Francesco, Ferrara, Francesco, Lancellotti, Francesco, Litta, Francesco, Martini, Francesco, Roscio, Francesco, Blanco-Antona, Francisco, Barcenas, Francisco Javier Quezada, Schlottmann, Francisco, Herrera-Almario, Gabriel, van Ramshorst, Gabrielle, Gallo, Gaetano, Luglio, Gaetano, Kampouroglou, Georgios, Papadopoulos, Georgios, Arredondo, Gerardo, Calini, Giacomo, Formisano, Giampaolo, Galiffa, Giampaolo, Palini, Gian Marco, Colucci, Gianluca, Pagano, Gianluca, Vanni, Gianluca, Pattacini, Gianmaria Casoni, Gravante, Gianpiero, Lisi, Giorgio, Bellanova, Giovanni, De Nobili, Giovanni, Necchi, Giovanni Sammy, Sinibaldi, Giovanni, Bacchiocchi, Giulia, Bagaglini, Giulia, Maggi, Giulia, Izzo, Giuliano, Argenio, Giulio, Brisinda, Giuseppe, Esposito, Giuseppe, Frazzetta, Giuseppe, De Luca, Giuseppe Massimiliano, Nigri, Giuseppe, Sica, Giuseppe, Martin-Martin, Gonzalo, Ugon, Gustavo Armand, Martinez-Mier, Gustavo, Machain Vega, Gustavo Miguel, Nari, Gustavo, Nikaj, Herald, Neri, Ignacio, San Roman, Igor Alberdi, Fidoshev, Iliya, Martínez, Iñaki, Negoi, Ionut, Ortega, Irene, Vicente Rodríguez, Irune, Cornejo, Isabel, Mora-Guzmán, Ismael, al-Najami, Issam, Romic, Ivan, Balciscueta, Izaskun, Olivier, James, Lammel-Lindemann, Jan, Dziakova, Jana, Salinas, Javier, Jovanovic, Jelena Pejanovic, Reyes, Jeryl Anne Silvia, Salas, Joanne, Diaz-Elizondo, Jose Antonio, Parreira, Jose Gustavo, Bellido, Juan, Salamea, Juan, Martín del Olmo, Juan Carlos, Ordoñez, Juliana María, Junaid, Sofi, Davies, Justin, Sahnan, Kapil, Bekele, Kebebe, Voon, Kelvin, Siragusa, Leandro, Petagna, Lorenzo, Ferrario, Luca, Giordano, Luca, Nespoli, Luca, Pio, Luca, Moletta, Lucia, Curella, Luciano, Taglietti, Lucio, Bonavina, Luigi, Conti, Luigi, Pérez-Sánchez, Luis Eduardo, Cabrera Vargas, Luis Felipe, Sánchez-Guillén, Luis, Tallon-Aguilar, Luis, Khan, Mansoor, Spampinato, Marcello Giuseppe, Viola, Marcelo, Malet, Marcelo Viola, Angrisani, Marco, Calussi, Marco, Catarci, Marco, Giordano, Marco, Materazzo, Marco, Milone, Marco, Pellicciaro, Marco, Marino, Marco Vito, Moreno Villamizar, María Daniela, Lolli, Maria Giulia, Bellini, Maria Irene, Lemma, Maria, Chiarello, Maria Michela, Montes-Manrique, Mario, Rodriguez-Lopez, Mario, Serradilla-Martín, Mario, Peter, Mark, Paniagua-García-Señoráns, Marta, Rutegård, Martin, Salö, Martin, Silveri, Massimiliano, Veroux, Massimiliano, Nardi, Matteo, Rottoli, Matteo, Tolonen, Matti, Pedraza Ciro, Mauricio, Zuluaga, Mauricio, Iacobone, Maurizio, Montuori, Mauro, Ali, Mazin, García Domínguez, Melody, Paola, Menna Maria, Piccoli, Micaela, Campanelli, Michela, De Rosa, Michele, Manigrasso, Michele, Maruccia, Michele, Torre, Michele, Zuolo, Michele, Pera, Miguel, Weerasekera, Mihiri, Prieto, Mikel, Thway, Min Myat, Shaat, Mohamed, Azfar, Mohammad, Shalaby, Mostafa, Raza, Muhammad Asif, Younis, Muhammad Umar, Elhadi, Muhammed, Ali, Mujahid, Althomali, Musab, Al Amri, Nadiah, Dudi-Venkata, Nagendra, Alselaim, Nahar, Smart, Neil, Trelles, Nelson, Falco, Nicolò, Petrucciani, Niccolo, Antonacci, Nicola, Cillara, Nicola, Gica, Nicolae, Pecorelli, Nicolò, Tamini, Nicolò, Machairas, Nikolaos, Feituri, Nura, Ortega Torrecilla, Nuria, Avila Mercado, Octavio, Alaamer, Ohood, Irkorucu, Oktay, Alsherif, Omar, Buonomi, Oreste Claudio, Valles-Guerra, Orestes, Ioannidis, Orestis, Hernández Palmas, Oscar Isaac, Sanz Guadarrama, Oscar, Bozbiyik, Osman, Rodrigues, Pablo, Milito, Pamela, Panaccio, Paolo, Dorovinis, Panagiotis, Prieto, Paola, Baroffio, Paolo, Marsanic, Patrizia, Ajawin, Pawel, Koh, Peng Soon, Anoldo, Pietro, Major, Piotr, Alharthi, Qasem, Lui, Rashid, Caruso, Riccardo, Brady, Richard, Rattan, Rishi, Singhal, Rishi, Angelico, Roberta, Isernia, Roberta Maria, Tutino, Roberta, Peltrini, Roberto, Tejos, Rodrigo, Fajardo, Roosevelt, Elia, Rossella, Morales-Conde, Salvador, Benli, Sami, Fuentes, Sara, de las Casas, Sara Gortázar, de Guzmán Aragón, Sara Ortiz, Vertaldi, Sara, Awad, Selmy, Gentilli, Sergio, Weckmann Lujan, Sergio Alberto, Tayar, Serkan, Althobaiti, Shabab, Di Giovanni, Silvia, Ghedan, Soliman, Pérez-Bertólez, Sonia, Chiappetta, Sonja, Delis, Spiros, Scaringi, Stefano, Çetinkünar, Süleyman, Kykalos, Stylianos, Muhammad Ali, Syed, Krivan, Sylvia, Fung, Tak Lit Derek, Delko, Tarik, Nicolás López, Tatiana, De Campos, Tercio, Calderón Duque, Teresa, Perra, Teresa, Liakakos, Theodore, Daskalakis, Theodoros, Koëter, Tijmen, Zalla, Tiku, González, Tomás Elosua, Campagnaro, Tommaso, Oumar, Toure Alpha, Grossi, Ugo, Sosa, Valentina, Testa, Valentina, Tomajer, Valentina, Andriola, Valeria, Tonini, Valeria, Celentano, Valerio, Voglino, Valerio, Katta, Venkateswara Rao, García Orozco, Víctor Hugo, Turrado-Rodriguez, Victor, Visag-Castillo, Victor, Graham, Victoria, Rachkov, Viktor, Papagni, Vincenzo, Vigorita, Vincenzo, Jiménez Carneros, Virginia, Bellato, Vittoria, Bechstein, Wolf, Altinel, Yuksel, Balciscueta, Zutoia, Pata, Francesco, Di Martino, Marcello, Podda, Mauro, Di Saverio, Salomone, Ielpo, Benedetto, Pellino, Gianluca, Luglio, Gaetano, Pata, F, Di Martino, M, Podda, M, Di Saverio, S, Ielpo, B, Pellino, G, Julio, A, Alshamrani, A, Alturkistani, A, Alghamdi, A, Almalki, A, Orengia, A, Kuvvetli, A, Pisanu, A, Smith, A, Trevino Figueroa, A, Nacion, A, Alhazmi, A, Bouhuwaish, A, Khalid, A, Alsufyani, A, Rubio, A, Bavikatte, A, Kumar, A, Jamiri, A, de San Ildefonso Pereira, A, Porcu, A, Sartori, A, Rocca, A, Sretenovic, A, Anselmo, A, De Luca, A, Charalabopoulos, A, Tzivanakis, A, Bandin, A, Najar, A, Frontali, A, Faisal, A, Roldan, A, Hamid, A, Andre, A, Minaya-Bravo, A, Das, A, Bondurri, A, Costanzi, A, Lucchi, A, Mihailescu, A, Police, A, Zuchini, A, Romano, A, Iossa, A, Chessa, A, Tromba, A, Castaldi, A, Brillantino, A, Ferronetti, A, Giuliani, A, Ramos-De la Medina, A, Tarasconi, A, Picciariello, A, Ioannidis, A, Leppaniemi, A, Rashid, A, Mitul, A, Mehraj, A, Laharwal, A, Iqbal, A, Liarakos, A, Marinis, A, de Andres-Asenjo, B, Matias-Garcia, B, De Simone, B, Creavin, B, Stubbs, B, Goh, B, Jovanovic, B, Sensi, B, Gazia, C, Cerdan, C, Diaz, C, Chacon, C, Yanez, C, Faro, C, Reinke, C, Dominguez, C, Paranjape, C, Thomas, C, Fung, C, De Lucia, C, Jennifer, C, Ovalle-Chao, C, Guerci, C, Kenington, C, Gica, C, Folliero, C, Varela, C, Popowich, D, Delogu, D, Zigiotto, D, Vinci, D, D'Antonio, D, Merlini, D, Moro-Valdezate, D, Keller, D, Nicolaescu, D, Sasia, D, Rodas, E, Linardoutsos, D, Russello, D, Najar-Castaneda, P, Stavrou, H, Rosso, E, Saladino, E, Ricciardi, E, Smith-Singares, E, Baili, E, Douka, E, Guaitoli, E, Francone, E, Vaterlini, E, Pierobon, E, Morales, E, Ros, E, Benzoni, E, Erdas, E, Pinotti, E, Colas-Ruiz, E, Laterza, E, Foianini, E, Cardamone, E, Licardie, E, Marino, F, Alsofyani, F, Qahtani, F, Khan, F, Maraska, F, Saliu, F, Madrid, F, Rosa, F, Luvisetto, F, Alconchel, F, Pareja-Ciuro, F, Neves, F, Agresta, F, Cordera, F, Pardo, F, Mendoza-Moreno, F, Munoz-Flores, F, Silvestri, F, Tropeano, F, Pecchini, F, Serio, F, Colombo, F, Di Marzo, F, Ferrara, F, Lancellotti, F, Litta, F, Martini, F, Roscio, F, Blanco-Antona, F, Barcenas, F, Schlottmann, F, Herrera-Almario, G, van Ramshorst, G, Gallo, G, Luglio, G, Kampouroglou, G, Papadopoulos, G, Arredondo, G, Calini, G, Formisano, G, Galiffa, G, Palini, G, Colucci, G, Pagano, G, Vanni, G, Pattacini, G, Gravante, G, Lisi, G, Bellanova, G, De Nobili, G, Necchi, G, Sinibaldi, G, Bacchiocchi, G, Bagaglini, G, Maggi, G, Izzo, G, Argenio, G, Brisinda, G, Esposito, G, Frazzetta, G, De Luca, G, Nigri, G, Sica, G, Martin-Martin, G, Ugon, G, Martinez-Mier, G, Machain Vega, G, Nari, G, Nikaj, H, Neri, I, San Roman, I, Fidoshev, I, Martinez, I, Negoi, I, Ortega, I, Vicente Rodriguez, I, Cornejo, I, Mora-Guzman, I, al-Najami, I, Romic, I, Balciscueta, I, Olivier, J, Lammel-Lindemann, J, Dziakova, J, Salinas, J, Jovanovic, J, Reyes, J, Salas, J, Diaz-Elizondo, J, Parreira, J, Bellido, J, Salamea, J, Martin del Olmo, J, Ordonez, J, Junaid, S, Davies, J, Sahnan, K, Bekele, K, Voon, K, Siragusa, L, Petagna, L, Ferrario, L, Giordano, L, Nespoli, L, Pio, L, Moletta, L, Curella, L, Taglietti, L, Bonavina, L, Conti, L, Perez-Sanchez, L, Cabrera Vargas, L, Sanchez-Guillen, L, Tallon-Aguilar, L, Khan, M, Spampinato, M, Viola, M, Malet, M, Angrisani, M, Calussi, M, Catarci, M, Giordano, M, Materazzo, M, Milone, M, Pellicciaro, M, Marino, M, Moreno Villamizar, M, Lolli, M, Bellini, M, Lemma, M, Chiarello, M, Montes-Manrique, M, Rodriguez-Lopez, M, Serradilla-Martin, M, Peter, M, Paniagua-Garcia-Senorans, M, Rutegard, M, Salo, M, Silveri, M, Veroux, M, Nardi, M, Rottoli, M, Tolonen, M, Pedraza Ciro, M, Zuluaga, M, Iacobone, M, Montuori, M, Ali, M, Garcia Dominguez, M, Paola, M, Piccoli, M, Campanelli, M, De Rosa, M, Manigrasso, M, Maruccia, M, Torre, M, Zuolo, M, Pera, M, Weerasekera, M, Prieto, M, Thway, M, Shaat, M, Azfar, M, Shalaby, M, Raza, M, Younis, M, Elhadi, M, Althomali, M, Al Amri, N, Dudi-Venkata, N, Alselaim, N, Smart, N, Trelles, N, Falco, N, Petrucciani, N, Antonacci, N, Cillara, N, Gica, N, Pecorelli, N, Tamini, N, Machairas, N, Feituri, N, Ortega Torrecilla, N, Avila Mercado, O, Alaamer, O, Irkorucu, O, Alsherif, O, Buonomi, O, Valles-Guerra, O, Ioannidis, O, Hernandez Palmas, O, Sanz Guadarrama, O, Bozbiyik, O, Rodrigues, P, Milito, P, Panaccio, P, Dorovinis, P, Prieto, P, Baroffio, P, Marsanic, P, Ajawin, P, Koh, P, Anoldo, P, Major, P, Alharthi, Q, Lui, R, Caruso, R, Brady, R, Rattan, R, Singhal, R, Angelico, R, Isernia, R, Tutino, R, Peltrini, R, Tejos, R, Fajardo, R, Elia, R, Morales-Conde, S, Benli, S, Fuentes, S, de las Casas, S, de Guzman Aragon, S, Vertaldi, S, Awad, S, Gentilli, S, Weckmann Lujan, S, Tayar, S, Althobaiti, S, Di Giovanni, S, Ghedan, S, Perez-Bertolez, S, Chiappetta, S, Delis, S, Scaringi, S, Cetinkunar, S, Kykalos, S, Muhammad Ali, S, Krivan, S, Fung, T, Delko, T, Nicolas Lopez, T, De Campos, T, Calderon Duque, T, Perra, T, Liakakos, T, Daskalakis, T, Koeter, T, Zalla, T, Gonzalez, T, Campagnaro, T, Oumar, T, Grossi, U, Sosa, V, Testa, V, Tomajer, V, Andriola, V, Tonini, V, Celentano, V, Voglino, V, Katta, V, Garcia Orozco, V, Turrado-Rodriguez, V, Visag-Castillo, V, Graham, V, Rachkov, V, Papagni, V, Vigorita, V, Jimenez Carneros, V, Bellato, V, Bechstein, W, Altinel, Y, Balciscueta, Z, Institut Català de la Salut, [Pata F] General Surgery Unit, UOC di Chirurgia, Nicola Giannettasio Hospital, CS, Italy. La Sapienza University, Rome, Italy. [Di Martino M] Division of Hepatobiliary and Liver Transplantation Surgery, A.O.R.N. Cardarelli, Naples, Italy. [Podda M] Department of Surgical Science, University of Cagliari, Cagliari, Italy. [Di Saverio S] Department of Surgery, Madonna del Soccorso General Hospital, San Benedetto del Tronto, Italy. [Ielpo B] Hepatobiliary division, Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain. [Pellino G] Department of Advanced Medical and Surgical Sciences, Universitá degli Studi della Campania ‘‘Luigi Vanvitelli’’, Policlinico CS, Naples, Italy. Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], covid-19, surgery, coronavirus, sars-cov-2, appendicectomy, laparoscopy, nom, management, Enquestes, Apendicectomia, COVID-19 (Malaltia), surgery, Surgical Procedures, Operative::Digestive System Surgical Procedures::Appendectomy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Apendicitis, Pandèmia de COVID-19, 2020, Appendectomy, Humans, Appendiciti, Pandemics, Cirurgia, Pandemic, SARS-CoV-2, COVID-19, Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Digestive System Diseases::Gastrointestinal Diseases::Appendicitis [DISEASES], Otros calificadores::Otros calificadores::/cirugía [Otros calificadores], técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Appendicitis, Apendicitis - Cirurgia, Other subheadings::Other subheadings::/surgery [Other subheadings], Settore MED/18, Settore MED/18 - Chirurgia Generale, Acute Disease, enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedades del sistema digestivo::enfermedades gastrointestinales::apendicitis [ENFERMEDADES], intervenciones quirúrgicas::procedimientos quirúrgicos del sistema digestivo::apendicectomía [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Human
Abstract

Background In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide.

Published
2022

91. Observation of two-neutrino double electron capture in 124Xe with XENON1T

Author

Aprile, E., Aalbers, J., Agostini, F., Alfonsi, M., Althueser, L., Amaro, F. D., Anthony, M., Antochi, V. C., Arneodo, F., Baudis, L., Bauermeister, B., Benabderrahmane, M. L., Berger, T., Breur, P. A., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Coderre, D., Colijn, A. P., Conrad, J., Cussonneau, J. P., Decowski, M. P., de Perio, P., di Gangi, P., di Giovanni, A., Diglio, S., Elykov, A., Eurin, G., Fei, J., Ferella, A. D., Fieguth, A., FULGIONE, VALTER, Gallo Rosso, A., Galloway, M., Gao, F., Garbini, M., Grandi, L., Greene, Z., Hasterok, C., Hogenbirk, E., Howlett, J., Iacovacci, M., Itay, R., Joerg, F., Kaminsky, B., Kazama, S., Kish, A., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Lin, Q., Lindemann, S., Lindner, M., Lombardi, F., Lopes, J. A. M., López Fune, E., Macolino, C., Mahlstedt, J., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Masbou, J., Masson, D., Mastroianni, S., Messina, M., Micheneau, K., Miller, K., Molinario, A., Morå, K., Murra, M., Naganoma, J., Ni, K., Oberlack, U., Odgers, K., Pelssers, B., Peres, R., Piastra, F., Pienaar, J., Pizzella, V., Plante, G., Podviianiuk, R., Priel, N., Qiu, H., Ramírez García, D., Reichard, S., Riedel, B., Rizzo, A., Rocchetti, A., Rupp, N., Dos Santos, J. M. F., Sartorelli, G., Šarčević, N., Scheibelhut, M., Schindler, S., Schreiner, J., Schulte, D., Schumann, M., Scotto Lavina, L., Selvi, M., Shagin, P., Shockley, E., Silva, M., Simgen, H., Therreau, C., Thers, D., Toschi, F., TRINCHERO, GIAN CARLO, Tunnell, C., Upole, N., Vargas, M., Wack, O., Wang, H., Wang, Z., Wei, Y., Weinheimer, C., Wenz, D., Wittweg, C., Wulf, J., Ye, J., Zhang, Y., Zhu, T., Zopounidis, J. P., XENON (IHEF, IoP, FNWI), Aprile, E., Aalbers, J., Agostini, F., Alfonsi, M., Althueser, L., Amaro, F. D., Anthony, M., Antochi, V. C., Arneodo, F., Baudis, L., Bauermeister2, B., Benabderrahmane, M. L., Berger, T., Breur, P. A., Brown, A., Brown, E., Bruenner, S., Bruno, G., Budnik, R., Capelli, C., Cardoso, J. M. R., Cichon, D., Coderre, D., Colijn, A. P., Conrad, J., Cussonneau, J. P., Decowski, M. P., de Perio, P., Di Gangi, P., Di Giovanni, A., Diglio, S., Elykov, A., Eurin, G., Fei, J., Ferella, A. D., Fieguth, A., Fulgione, W., Gallo Rosso, A., Galloway, M., Gao, F., Garbini, M., Grandi, L., Greene, Z., Hasterok, C., Hogenbirk, E., Howlett, J., Iacovacci, M., Itay, R., Joerg, F., Kaminsky, B., Kazama, S., Kish, A., Koltman, G., Kopec, A., Landsman, H., Lang, R. F., Levinson, L., Lin, Q., Lindemann, S., Lindner, M., Lombardi, F., Lopes, J. A. M., López Fune, E., Macolino, C., Mahlstedt, J., Manfredini, A., Marignetti, F., Marrodán Undagoitia, T., Masbou, J., Masson, D., Mastroianni, S., Messina, M., Micheneau, K., Miller, K., Molinario, A., Morå, K., Murra, M., Naganoma, J., Ni, K., Oberlack, U., Odgers, K., Pelssers, B., Peres, R., Piastra, F., Pienaar, J., Pizzella, V., Plante, G., Podviianiuk, R., Priel, N., Qiu, H., Ramírez García, D., Reichard, S., Riedel, B., Rizzo, A., Rocchetti, A., Rupp, N., dos Santos, J. M. F., Sartorelli, G., Šarčević, N., Scheibelhut, M., Schindler, S., Schreiner, J., Schulte, D., Schumann, M., Scotto Lavina, L., Selvi, M., Shagin, P., Shockley, E., Silva, M., Simgen, H., Therreau, C., Thers, D., Toschi, F., Trinchero, G., Tunnell, C., Upole, N., Vargas, M., Wack, O., Wang, H., Wang, Z., Wei, Y., Weinheimer, C., Wenz, D., Wittweg, C., Wulf, J., Ye, J., Zhang, Y., Zhu &amp, T., Zopounidis, J. P., E. Aprile, J. Aalbers, F. Agostini, M. Alfonsi, L. Althueser, F. D. Amaro, M. Anthony, V. C. Antochi, F. Arneodo, L. Baudis, B. Bauermeister, M. L. Benabderrahmane, T. Berger, P. A. Breur, A. Brown, A. Brown, E. Brown, S. Bruenner, G. Bruno, R. Budnik, C. Capelli, J. M. R. Cardoso, D. Cichon, D. Coderre, A. P. Colijn, J. Conrad, J. P. Cussonneau, M. P. Decowski, P. de Perio, P. Di Gangi, A. Di Giovanni, S. Diglio, A. Elykov, G. Eurin, J. Fei, A. D. Ferella, A. Fieguth, W. Fulgione, A. Gallo Rosso, M. Galloway, F. Gao, M. Garbini, L. Grandi, Z. Greene, C. Hasterok, E. Hogenbirk, J. Howlett, M. Iacovacci, R. Itay, F. Joerg, B. Kaminsky, S. Kazama, A. Kish, G. Koltman, A. Kopec, H. Landsman, R. F. Lang, L. Levinson, Q. Lin, S. Lindemann, M. Lindner, F. Lombardi, J. A. M. Lopes, E. López Fune, C. Macolino, J. Mahlstedt, A. Manfredini, F. Marignetti, T. Marrodán Undagoitia, J. Masbou, D. Masson, S. Mastroianni, M. Messina, K. Micheneau, K. Miller, A. Molinario, K. Morå, M. Murra, J. Naganoma, K. Ni, U. Oberlack, K. Odgers, B. Pelssers, R. Peres, F. Piastra, J. Pienaar, V. Pizzella, G. Plante, R. Podviianiuk, N. Priel, H. Qiu, D. Ramírez García, S. Reichard, B. Riedel, A. Rizzo, A. Rocchetti, N. Rupp, J. M. F. dos Santos, G. Sartorelli, N. Šarčević, M. Scheibelhut, S. Schindler, J. Schreiner, D. Schulte, M. Schumann, L. Scotto Lavina, M. Selvi, P. Shagin, E. Shockley, M. Silva, H. Simgen, C. Therreau, D. Thers, F. Toschi, G. Trinchero, C. Tunnell, N. Upole, M. Vargas, O. Wack, H. Wang, Z. Wang, Y. Wei, C. Weinheimer, D. Wenz, C. Wittweg, J. Wulf, J. Ye, Y. Zhang, T. Zhu & J. P. Zopounidis, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), XENON, Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique)

Subjects
electron, Particle physics, Xenon, half-life, Age of the universe, Electron capture, Dark matter, background: model, chemistry.chemical_element, FOS: Physical sciences, electron: capture, n: thermal, 7. Clean energy, 01 natural sciences, weak process, background: low, Neutrino, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, S076H2N, Physics, xenon: liquid, Multidisciplinary, Isotope, 010308 nuclear & particles physics, iodine, neutrino: Majorana: mass, higher-order: 2, Nuclear structure, double-beta decay, dark matter: detector, energy: calibration, Neutrino, Xenon, half-life, electron, double electron capture, weak process, double electron capture, Orders of magnitude (time), chemistry, Dark Matter detector Electron Capture Low Background Double Beta Decay, xenon: nuclide, target: mass, numerical calculations: Monte Carlo, energy spectrum: measured, statistical, acceptance
Abstract

International audience; Two-neutrino double electron capture (2νECEC) is a second-order weak-interaction process with a predicted half-life that surpasses the age of the Universe by many orders of magnitude1. Until now, indications of 2νECEC decays have only been seen for two isotopes2,3,4,5, 78Kr and 130Ba, and instruments with very low background levels are needed to detect them directly with high statistical significance6,7. The 2νECEC half-life is an important observable for nuclear structure models8,9,10,11,12,13,14 and its measurement represents a meaningful step in the search for neutrinoless double electron capture—the detection of which would establish the Majorana nature of the neutrino and would give access to the absolute neutrino mass15,16,17. Here we report the direct observation of 2νECEC in 124Xe with the XENON1T dark-matter detector. The significance of the signal is 4.4 standard deviations and the corresponding half-life of 1.8 × 1022 years (statistical uncertainty, 0.5 × 1022 years; systematic uncertainty, 0.1 × 1022 years) is the longest measured directly so far. This study demonstrates that the low background and large target mass of xenon-based dark-matter detectors make them well suited for measuring rare processes and highlights the broad physics reach of larger next-generation experiments18,19,20.

Published
2019
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92. Structural features of the glutamate-binding protein from Corynebacterium glutamicum

Author

Antonio Varriale, Alessandro Capo, Antonino Natalello, Sabato D'Auria, Maria Staiano, Alessandra Camarca, Jan Marienhagen, Stefano Di Giovanni, Angela Pennacchio, Capo, A, Natalello, A, Marienhagen, J, Pennacchio, A, Camarca, A, Di Giovanni, S, Staiano, M, D'Auria, S, and Varriale, A

Subjects
Glutamate binding protein, Glutamine, Cell, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), 02 engineering and technology, Biochemistry, Corynebacterium glutamicum, 03 medical and health sciences, Capillary electrophoresis, Protein structure, Structural Biology, ddc:570, medicine, Enhancer, Fluorescence spectroscopy, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Glutamate binding, General Medicine, 021001 nanoscience & nanotechnology, Ligand (biochemistry), biology.organism_classification, FT-IR, medicine.anatomical_structure, Periplasmic Binding Proteins, ATP-Binding Cassette Transporters, 0210 nano-technology, Bacteria
Abstract

L-glutamate (Glu) is the major excitatory transmitter in mammalian brain. Inadequate concentration of Glu in the brain correlates to mood disorder. In industry, Glu is used as a flavour enhancer in food and in foodstuff processing. A high concentration of Glu has several effects on human health such as hypersensitive effects, headache and stomach pain. The presence of Glu in food can be detected by different analytical methods based on chromatography, or capillary electrophoresis or amperometric techniques. We have isolated and characterized a glutamate-binding protein (GluB) from the Gram-positive bacteria Corynebacterium glutamicum. Together with GluC protein, GluD protein and the cytoplasmic protein GluA, GluB permits the transport of Glu in/out of cell. In this study, we have investigated the binding features of GluB as well as the effect of temperature on its structure both in the absence and in the presence of Glu. The results have showed that GluB has a high affinity and selectivity versus Glu (nanomolar range) and the presence of the ligand induces a higher thermal stability of the protein structure. (C) 2020 Elsevier B.V. All rights reserved.

Published
2020
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93. 'Relaparoscopic' management of surgical complications: The experience of an Emergency Center

Author

Giorgio Romano, Giuseppe Frazzetta, Vincenzo Sorce, Daniela Chianetta, Antonino Agrusa, Leonardo Gulotta, Gaspare Gulotta, Silvia Di Giovanni, Giuseppe Di Buno, Agrusa, A, Frazzetta, G, Chianetta, D, Di Giovanni, S, Gulotta, L, Di Buono, G, Sorce, V, Romano, G, and Gulotta, G

Subjects
Male, Laparoscopic surgery, “Second-look” surgery, Delayed Diagnosis, Time Factors, medicine.medical_treatment, law.invention, Cohort Studies, Postoperative Complications, 0302 clinical medicine, law, Laparotomy, Medicine, Laparoscopy, Digestive System Surgical Procedures, Aged, 80 and over, medicine.diagnostic_test, Middle Aged, Conversion to Open Surgery, Intensive care unit, Relaproscopy, Surgical complications, “Redo” surgery, Surgery, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Adult, Reoperation, medicine.medical_specialty, Abdominal Abscess, Adolescent, Ileus, Operative Time, Young Adult, 03 medical and health sciences, Surgical complication, Appendectomy, Humans, Surgical Wound Infection, Cholecystectomy, Mortality, Aged, Retrospective Studies, business.industry, Retrospective cohort study, Length of Stay, medicine.disease, Settore MED/18 - Chirurgia Generale, Second-Look Surgery, business, Abdominal surgery
Abstract

Background/aim: Laparotomy has been the approach of choice for re-operations in patients with surgical complications. The aim of this retrospective analysis was to evaluate the feasibility and the safety of laparoscopic approach for the management of general abdominal surgery complications. Materials and methods: We report a retrospective review of 75 patients who underwent laparoscopic evaluation for postoperative complications over a 4-year period. Primary outcomes (resolution rate by exclusive laparoscopic approach, conversion rate, further surgery rate) and secondary outcomes (mortality, hospitalization, prolonged ileus, wounds problems and median operative time) were evaluated. Results: Sixty-six patients (88 %) were managed with laparoscopic approach without conversion; of these, sixty-three patients (84 %) had no more or further complications and were discharged from hospital between 4 ± 3 days after “second-look” surgery; three patients (4 %) developed postoperative complications requiring a third surgery. Nine cases (12 %) underwent conversion in open surgery after laparoscopic approach. Two elderly patients (2.7 %) died in intensive care unit, because of multi-organ failure syndrome. Median time elapsed between an intervention and another was about 2.5 ± 9.5 days. Mean operative time was 90 ± 150 min. Postoperative hospital stay was between 4.5 and 18 days. Discussion and conclusion: Laparoscopy has begun to be the preferred method to manage postoperative problems, but only few reports are available actually. Our experience in “relaparoscopic” management of surgical complications seems to suggest that laparoscopy “second look” is an effective tool after open or laparoscopic surgery for the management of postoperative complications and it may avoid diagnostic delay and further laparotomy and related problems.

Published
2015
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94. Tradurre Mary Phil Korsak

Author

Ira Torresi, E. Di Giovanni, S. Zanotti, and Ira Torresi

Subjects
Genere, Genesi, traduzione biblica, Mary Phil Korsak, femminismo, Women's Bible
Abstract

Il saggio rende conto degli approfondimenti che si sono resi necessari durante la traduzione del capitolo "Tradurre la Bibbia: traduzione biblica e questioni di genere", che lo precede nel volume. La prima riflessione è sulla diversa rilevanza della traduzione biblica nei rispettivi panorami femministi italiano e anglosassone; in quest'ultimo, le prime revisioni in chiave suffragista del testo biblico risalgono alla seconda metà del 1800. È in questo contesto, che ha ormai metabolizzato alcune scelte traduttive (come la famosa 'costola d'Adamo') come profondamente influenzate da un'ottica patriarcale, che Korsak può paradossalmente rivendicare una traduzione non politica, ma solo filologica, per il suo testo della Genesi. Cionondimento, la sua versione, che intende essere più vicina alla lettera dell'originale ebraico rispetto alle traduzioni inglesi più usate, ha una portata ideologica dirompente. Il saggio si chiude con alcune precisazioni metatraduttive, sulle traslitterazioni dall’ebraico e sul raffronto delle varie versioni della Genesi, in cui alle versioni inglesi sono state giustapposte le rispettive traduzioni italiane, il più possibile letterali.

Published
2018

95. Tradurre la Bibbia: Traduzioni bibliche e questioni di genere

Author

Ira Torresi, Susan Bassnett, Carol Maier, Barbara Godard, Rosemary Arroyo, Sherry Simon, Louise Von Flotow/Joan W. Scott, Emily Apter, Toril Moi, Pascale Sardin, Mary Phil Korsak, Olga Castro, Luise F. Pusch, Cláudia de Lima Costa/Sonia E. Alvarez, Meena T. Pillai, Katherine E. Russo, Raffaella Baccolini/Valeria Illuminati, E. Di Giovanni, S. Zanotti, and Ira Torresi

Subjects
genere, Genesi, traduzione biblica
Abstract

Il saggio si concentra sulla patriarcalizzazione e successiva normativizzazione della rappresentazione dei generi nelle traduzioni storiche dell’Antico Testamento, che – secondo le ricerche e l’esperienza traduttiva dell’autrice – non sono sempre insite nel testo ebraico. Mary Phil Korsak parte dalla disamina di alcune pietre miliari della traduzione biblica in inglese per arrivare a una discussione di alcuni esempi tratti dalla propria ritraduzione della Genesi dall’ebraico antico (At the start: Genesis made new). Così facendo, porta alla luce alcune peculiarità, ormai diventate memi culturali nel modo anglosassone (ma anche nel resto del mondo occidentale, attraverso una storia traduttiva simile), tese a mettere in luce il genere maschile su quello femminile. Per citarne una, il nome ebraico di Adamo prima della nascita della donna da una sua “costola” (in realtà, un suo lato o metà) non era maschile, bensì neutro; quindi la nascita della donna è coeva a quella dell’uomo inteso come genere maschile; e prima di tale evento, Adamo (Adam) non era che, etimologicamente, “progenie della terra” senza un sesso definito. Processi simili si sono stratificati nei secoli, sedimentandosi attraverso le traduzioni e commentari biblici che scaturirono per la maggior parte da menti maschili in epoche e società fortemente improntate a una prospettiva patriarcale.

Published
2018

96. Esophageal Motility Changes after Thyroidectomy; Possible Associations with Postoperative Voice and Swallowing Disorders: Preliminary Results

Author

Gaspare Gulotta, Piero Luigi Almasio, Angela Inviati, Francesco Cupido, Nunzia Cinzia Paladino, Sebastiano Bonventre, Giuseppe Lo Re, Gregorio Scerrino, Silvia Di Giovanni, Valentina Di Paola, Sterrino, G, Inviati A, Di Giovanni, S, Paladino, NC, Di Paola, V, Lo Re, G, Almasio, PL, Cupido, F, Gulotta, G, and Bonventre S

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Manometry, medicine.medical_treatment, Comorbidity, Audiology, Risk Assessment, Severity of Illness Index, Statistics, Nonparametric, Cohort Studies, Young Adult, Age Distribution, medicine, Humans, Esophageal Motility Disorders, Prospective Studies, Sex Distribution, dysphagia, thyroidectomy, voice impairment, Aged, Voice impairment, Settore MED/12 - Gastroenterologia, Voice Disorders, business.industry, Incidence, Swallowing Disorders, Thyroidectomy, Middle Aged, Thyroid Diseases, Settore MED/45 - Scienze Infermieristiche Generali, Cliniche E Pediatriche, Settore MED/18 - Chirurgia Generale, Settore MED/31 - Otorinolaringoiatria, Italy, Otorhinolaryngology, Anesthesia, Female, Surgery, Deglutition Disorders, business, Esophageal motility, Follow-Up Studies
Abstract

Objective Swallowing and voice impairment are common after thyroidectomy. We evaluated short-term functional changes in esophageal motility in a series of patients who had undergone total thyroidectomy. Several studies have investigated these symptoms by means of interviews or questionnaires. Study Design Prospective study. Setting Academic research. Materials and Methods Thirty-six consenting patients were prospectively recruited. Eligibility criteria were thyroid volume ≤60 mL, benign disease, and age between 18 and 65 years. Exclusion criteria were previous neck surgery, severe thyroiditis, hyperthyroidism, and pre- or postoperative vocal cord palsy. Voice impairment score, swallowing impairment score, lower esophageal sphincter pressure, esophageal motility, upper esophageal pressure, and coordination were evaluated preoperatively and 30 to 45 days after surgery. Results Postoperative swallowing impairment (appearance or worsening of dysphagia) was found in 20% of patients and voice impairment in more than 30%. Both preoperative and postoperative esophageal motility were similar. All patients showed an average decrease of 25% in upper esophageal pressure, although the pressure was within normal range. Swallowing alterations were associated with upper esophageal incoordination (P < .03), and proximal acid reflux was significantly associated with voice impairment (P < .02). Conclusion After uncomplicated thyroidectomy, decreased upper esophageal pressure may explain both pharyngeal (dysphagia) and laryngeal (vocal impairment) exposure to acid. In the future, proton pump inhibitor therapy protocols should be evaluated.

Published
2013
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97. Long-term esophageal motility changes after thyroidectomy: associations with aerodigestive disorders

Author

G, Scerrino, A, Inviati, S, Di Giovanni, N C, Paladino, V, Di Paola, C, Raspanti, G I, Melfa, F, Cupido, S, Mazzola, C, Porrello, S, Bonventre, G, Gullotta, Scerrino, G., Inviati, A., Di Giovanni, S., Paladino, N., Di Paola, V., Raspanti, C., Melfa, G., Cupido, F., Mazzola, S., Porrello, C., Bonventre, S., and Gulotta, G

Subjects
Larynx, Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Manometry, medicine.medical_treatment, aerodigestive disorders thyroidectomy, Risk Assessment, Severity of Illness Index, Thyroiditis, 03 medical and health sciences, 0302 clinical medicine, Swallowing, Risk Factors, medicine, Humans, Esophageal Motility Disorders, Prospective Studies, Esophagus, Prospective cohort study, Aged, Voice Disorders, business.industry, Pharynx, Reflux, Thyroidectomy, Middle Aged, medicine.disease, Surgery, Settore MED/18 - Chirurgia Generale, medicine.anatomical_structure, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, Original Article, business, Deglutition Disorders
Abstract

BACKGROUND: Patients undergoing thyroidectomy often complain aerodigestive disorders. In a previous study we showed the associations between voice impairment and proximal acid reflux, swallowing impairment and Upper Esophageal Sphyncter (UES) incoordination and the decrease in UES pressure in thirty-six patients observed before and soon afterwards uncomplicated thyroidectomy. This study investigated the state of post-thyroidectomy esophageal motility changes and its associations with these disorders after 18-24 months. PATIENTS AND METHODS: The thirty-six patients prospectively recruited according to selection criteria (thyroid volume ≤60 ml, benign disease, age 18-65 years, previous neck surgery, thyroiditis, pre- or postoperative vocal cord palsy) underwent voice (VIS) and swallowing (SIS) impairment scores, esophageal manometry and pH monitoring once again. RESULTS: After 18-24 months, both VIS and SIS recovered (respectively: p=0,022; p=0,0001); UES pressure increased (p=0,0001) nearing the preoperative values. The persistence of swallowing complaints were associated with the persistence of esophageal incoordination (p=0,03); the association between voice impairment and proximal acid reflux was confirmed (p

Published
2017

98. A functional study of the esophagus in patients with non-cardiac chest pain and dysphagia

Author

Piero Luigi Almasio, Sebastiano Bonventre, Valentina Di Paola, Silvia Di Giovanni, Gregorio Scerrino, Gaspare Gulotta, Angela Inviati, Roberto Gullo, Gullo, R., Inviati, A., Almasio, P., Di Paola, V., Di Giovanni, S., Scerrino, G., Gulotta, G., and Bonventre, S

Subjects
Adult, Male, medicine.medical_specialty, Chest Pain, Manometry, Achalasia, Chest pain, Esophagu, Gastroenterology, Esophageal Sphincter, Lower, Esophagus, Retrospective Studie, Internal medicine, otorhinolaryngologic diseases, medicine, Humans, In patient, Deglutition Disorder, Non-cardiac chest pain, Aged, Retrospective Studies, Settore MED/12 - Gastroenterologia, business.industry, Medicine (all), Esophageal dyskinesia, Dysphagia, Gastroesophageal reflux, Deglutition Disorders, Esophageal Achalasia, Esophageal Sphincter, Upper, Female, Gastroesophageal Reflux, Hydrogen-Ion Concentration, Middle Aged, Reflux, Nutcracker esophagus, medicine.disease, Surgery, Settore MED/18 - Chirurgia Generale, medicine.anatomical_structure, Esophageal spasm, medicine.symptom, business, Human
Abstract

Background/Aims: Nutcracker esophagus and non-specific motility disorders are the main causes of non-cardiac chest pain (NCCP), with gastroesophageal reflux in 60% of cases. Achalasia and diffuse esophageal spasm are the most frequent anomalies described in patients with dysphagia. The goal of this study was to evaluate the occurrence of esophageal body and lower esophageal sphincter motor abnormalities in patients with dysphagia, NCCP, or both. Materials and Methods: This study is a retrospective analysis of 716 patients with NCCP and/or dysphagia tested between January 1994 and December 2010. 1023 functional studies were performed, 707 of which were esophageal manometries, 225 esophageal pH-meters, and 44 bilimetries. We divided the patients into three groups: group 1 was composed of patients affected with dysphagia, group 2 with NCCP and group 3 with NCCP and dysphagia. Results: Manometric anomalies were detected in 84.4% of cases (p

Published
2015

99. Corrigendum to 'Hiatal Hernia Repair with Gore Bio-A Tissue Reinforcement: Our Experience'

Author

Giuseppe Di Buono, Giuseppe Frazzetta, Silvia Di Giovanni, Gaspare Gulotta, Giovanni De Vita, Daniela Chianetta, Vincenzo Sorce, Giorgio Romano, Antonino Agrusa, Agrusa, A, Romano, G, Frazzetta, G, Chianetta, D, De Vita, G, Di Buono, G, Sorce, V, Di Giovanni, S, and Gulotta, G

Subjects
Hiatal hernia repair, hiatal hernia - laparoscopic repair, medicine.medical_specialty, Settore MED/18 - Chirurgia Generale, business.industry, lcsh:Surgery, Medicine, Pharmacology (medical), lcsh:RD1-811, business, Surgery
Abstract

Type I hiatal hernia is associated with gastroesophageal reflux disease (GERD) in 50-90% of cases. Several trials strongly support surgery as an effective alternative to medical therapy. Today, laparoscopic fundoplication is considered as the procedure of choice. However, primary laparoscopic hiatal hernia repair is associated with upto 42% recurrence rate. Mesh reinforcement of the crural closure decreases the recurrence but can lead to complications, above all nonabsorbable ones. We experiment a new totally absorbable mesh by Gore. Case. We present a case of a 65-year-old female patient with a 6-year classic history of GERD. Endoscopy revealed a large hiatal hernia and esophagitis. pH study was positive for acid reflux; esophageal manometry revealed LES intrathoracic dislocation. With laparoscopic approach, the hiatal hernia defect was identified and primarily repaired, by crural closure. Gore Bio-A Tissue Reinforcement was trimmed to fit the defect accommodating the esophagus. Nissen fundoplication was performed. Result. Bio-A mesh was easily placed laparoscopically. It has good handling and could be cut and tailored intraoperatively for optimal adaptation. There were no short-term complications. Conclusion. Crural closure reinforcement can be done readily with this new totally absorbable mesh replaced by soft tissue over six months. However, further data and studies are needed to evaluate long-term outcomes.

Published
2015

100. Esophageal motility changes after thyroidectomy: possible associations with postoperative voice and swallowing disorders

Author

Scerrino,G, PALADINO, Nunzia Cinzia, INVIATI, Angela, DI PAOLA, Valentina, DI GIOVANNI, Silvia, GULLO, Roberto, CUPIDO, Francesco, ALMASIO, Pier Luigi, BONVENTRE, Sebastiano, Scerrino,G, Paladino,NC, Inviati,A, Di Paola,V, Di Giovanni,S, Gullo,R, Cupido,F, Almasio,P, and Bonventre,S

Subjects
Settore MED/18 - Chirurgia Generale, Settore MED/12 - Gastroenterologia, Settore MED/31 - Otorinolaringoiatria, Settore MED/45 - Scienze Infermieristiche Generali, Cliniche E Pediatriche, esophageal motility, thyroidectomy
Published
2012

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