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51. Costs of inadvertent perioperative hypothermia in Australia: A cost-of-illness study

Author

Ralph, N, Gow, J, Conway, A, Duff, J, Edward, KL, Alexander, K, and Bräuer, A

Subjects
1110 Nursing, Nursing, health care economics and organizations
Abstract

Background: A definitive cost analysis of preventing inadvertent perioperative hypothermia (IPH) in surgical patients in Australia is lacking. Preventing IPH is a common nurse-led initiative in surgery and cost savings represent the value of nursing care. Aim: The study aims are twofold. First, we aim to estimate the cost of the current prevalence of IPH in Australian hospitals. Second, is to estimate the potential cost reductions that could be realised by reducing IPH prevalence by using a thermal care bundle. Methods: Cost-of-illness analysis measures the economic burden of illness to society. It does so by identifying and measuring all costs of a disease or illness such as IPH. It was undertaken using a prevalence approach and a one-year time horizon. Findings: The annual costs of IPH to the Australian health system can be estimated to be $1,259,725,856. The annual net benefit of IPH prevention to the Australian health system is $602 million. Using a thermal care bundle to reduce IPH by actively warming 80% of the patients that are not warmed yet could save $657.1 million per year at the expense of $18.4 million. Discussion: Preventing IPH using active warming is estimated to lead to significant cost savings across the Australian health system. It is recommended that a national policy for preventing IPH is needed and guidelines must reflect up-to-date strategies for preventing IPH including active prewarming. Conclusion: The Thermal Care Bundle should be adopted to lower IPH incidence and associated costs in Australia.

Published
2020

52. Homozygous TAF1C variants are associated with a novel childhood‐onset neurological phenotype

Author

Knuutinen, O. (Oula), Pyle, A. (Angela), Suo-Palosaari, M. (Maria), Duff, J. (Jennifer), Froukh, T. (Tawfiq), Lehesjoki, A.-E. (Anna-Elina), Kangas, S. M. (Salla M.), Cassidy, J. (James), Maraqa, L. (Latifa), Keski-Filppula, R. (Riikka), Kokkonen, H. (Hannaleena), Uusimaa, J. (Johanna), Horvath, R. (Rita), and Vieira, P. (Päivi)

Subjects
TATAbinding protein associated factors, Pol1 transcription initiation complex proteins, brain atrophy, infantile spasms
Abstract

TATA‐box binding protein associated factor, RNA polymerase I subunit C (TAF1C) is a component of selectivity factor 1 belonging to RNA polymerase I (Pol I) transcription machinery. We report two unrelated patients with homozygous TAF1C missense variants and an early onset neurological phenotype with severe global developmental delay. Clinical features included lack of speech and ambulation and epilepsy. MRI of the brain demonstrated widespread cerebral atrophy and frontal periventricular white matter hyperintensity. The phenotype resembled that of a previously described variant of UBTF, which encodes another transcription factor of Pol I. TAF1C variants were located in two conserved amino acid positions and were predicted to be deleterious. In patient‐derived fibroblasts, TAF1C mRNA and protein expression levels were substantially reduced compared with healthy controls. We propose that the variants impairing TAF1C expression are likely pathogenic and relate to a novel neurological disease. This study expands the disease spectrum related to Pol I transcription machinery, associating the TAF1C missense variants with a severe neurological phenotype for the first time.

Published
2020

53. Targeted Molecular Therapy in Palliative Cancer Management

Author

Staats H, Cassidy C, Kelso J, Mack S, Morand S, Choucair K, Qaqish H, Willis O, Craig D, Duff J, Stanbery L, Edelman G, Dworkin L, and Nemunaitis J

Subjects
Oncology, medicine.medical_specialty, business.industry, Cancer, Guideline, Precision medicine, Malignancy, medicine.disease, Internal medicine, Targeted Molecular Therapy, Cancer management, medicine, Molecular targets, business, PI3K/AKT/mTOR pathway
Abstract

Acknowledging the correlation of response to therapy based on the “targeting the target” concept, FDA demonstrated confidence in precision therapy approaches by approving Foundation One® CDx test in late 2017 as an indicated diagnostic for cancer patients. More than 100 precision therapies involving both solid and liquid malignancy have since been approved by FDA as indicated therapy in a variety of cancer types as related to correlated molecular target. We provide clinical justification of consideration for precision therapy guided by matched molecular target, specifically focusing on PI3K/mTOR/AKT, BRCA, CDK4/6, EGFR and BRAF V600E for advanced disease cancer patients who previously failed optimal NCCN guideline directed standard of care.

Published
2020
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54. Common quantitative methods

Author

Whitehead, D., Ferguson, C., LoBiondo-Wood, G., Haber, J., Duff, J., Conway, Aaron, Whitehead, D., Ferguson, C., LoBiondo-Wood, G., Haber, J., Duff, J., and Conway, Aaron

Published
2020

55. A unified call to action from Australian nursing and midwifery leaders: Ensuring that Black lives matter

Author

Geia, L., Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., de Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, C., Dunning, T., East, L., Elliott, D., Elmir, R., Fergie OAM, D., Ferguson, C., Fernandez, R., Flower AM, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer AO, C. S. E., Hungerford, C., Hutton, A., Jackson AO, D., Johnson, A., Kelly, M.A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam OAM, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Phillips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher AM, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., Wynne, R., Geia, L., Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., de Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, C., Dunning, T., East, L., Elliott, D., Elmir, R., Fergie OAM, D., Ferguson, C., Fernandez, R., Flower AM, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer AO, C. S. E., Hungerford, C., Hutton, A., Jackson AO, D., Johnson, A., Kelly, M.A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam OAM, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Phillips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher AM, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., and Wynne, R.

Abstract

Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a ‘now window’ of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.

Published
2020

56. A unified call to action from Australian nursing and midwifery leaders: Ensuring that Black lives matter

Author

Geia, Lynore, Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., De Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, Christine M, Dunning, T., East, L., Elliott, D., Elmir, R., Fergie, D., Ferguson, C., Fernandez, R., Flower, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer, C. S. E., Hungerford, C., Hutton, A., Jackson, D., Johnson, A., Kelly, M. A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, A.M.R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Philips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., Wynne, R., Geia, Lynore, Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., De Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, Christine M, Dunning, T., East, L., Elliott, D., Elmir, R., Fergie, D., Ferguson, C., Fernandez, R., Flower, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer, C. S. E., Hungerford, C., Hutton, A., Jackson, D., Johnson, A., Kelly, M. A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, A.M.R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Philips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., and Wynne, R.

Abstract

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a ‘now window’ of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.

Published
2020

57. Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency

Author

Hathazi, D. (Denisa), Griffin, H. (Helen), Jennings, M. J. (Matthew J.), Giunta, M. (Michele), Powell, C. (Christopher), Pearce, S. F. (Sarah F.), Munro, B. (Benjamin), Wei, W. (Wei), Boczonadi, V. (Veronika), Poulton, J. (Joanna), Pyle, A. (Angela), Calabrese, C. (Claudia), Gomez‐Duran, A. (Aurora), Schara, U. (Ulrike), Pitceathly, R. D. (Robert D. S.), Hanna, M. G. (Michael G.), Joost, K. (Kairit), Cotta, A. (Ana), Paim, J. F. (Julia Filardi), Navarro, M. M. (Monica Machado), Duff, J. (Jennifer), Mattman, A. (Andre), Chapman, K. (Kristine), Servidei, S. (Serenella), Marina, A. D. (Adela Della), Uusimaa, J. (Johanna), Roos, A. (Andreas), Mootha, V. (Vamsi), Hirano, M. (Michio), Tulinius, M. (Mar), Giri, M. (Mamta), Hoffmann, E. P. (Eric P.), Lochmüller, H. (Hanns), DiMauro, S. (Salvatore), Minczuk, M. (Michal), Chinnery, P. F. (Patrick F.), Müller, J. S. (Juliane S.), Horvath, R. (Rita), Hathazi, D. (Denisa), Griffin, H. (Helen), Jennings, M. J. (Matthew J.), Giunta, M. (Michele), Powell, C. (Christopher), Pearce, S. F. (Sarah F.), Munro, B. (Benjamin), Wei, W. (Wei), Boczonadi, V. (Veronika), Poulton, J. (Joanna), Pyle, A. (Angela), Calabrese, C. (Claudia), Gomez‐Duran, A. (Aurora), Schara, U. (Ulrike), Pitceathly, R. D. (Robert D. S.), Hanna, M. G. (Michael G.), Joost, K. (Kairit), Cotta, A. (Ana), Paim, J. F. (Julia Filardi), Navarro, M. M. (Monica Machado), Duff, J. (Jennifer), Mattman, A. (Andre), Chapman, K. (Kristine), Servidei, S. (Serenella), Marina, A. D. (Adela Della), Uusimaa, J. (Johanna), Roos, A. (Andreas), Mootha, V. (Vamsi), Hirano, M. (Michio), Tulinius, M. (Mar), Giri, M. (Mamta), Hoffmann, E. P. (Eric P.), Lochmüller, H. (Hanns), DiMauro, S. (Salvatore), Minczuk, M. (Michal), Chinnery, P. F. (Patrick F.), Müller, J. S. (Juliane S.), and Horvath, R. (Rita)

Abstract

Reversible infantile respiratory chain deficiency (RIRCD) is a rare mitochondrial myopathy leading to severe metabolic disturbances in infants, which recover spontaneously after 6‐months of age. RIRCD is associated with the homoplasmic m.14674T>C mitochondrial DNA mutation; however, only ~ 1/100 carriers develop the disease. We studied 27 affected and 15 unaffected individuals from 19 families and found additional heterozygous mutations in nuclear genes interacting with mt‐tRNAGlu including EARS2 and TRMU in the majority of affected individuals, but not in healthy carriers of m.14674T>C, supporting a digenic inheritance. Our transcriptomic and proteomic analysis of patient muscle suggests a stepwise mechanism where first, the integrated stress response associated with increased FGF21 and GDF15 expression enhances the metabolism modulated by serine biosynthesis, one carbon metabolism, TCA lipid oxidation and amino acid availability, while in the second step mTOR activation leads to increased mitochondrial biogenesis. Our data suggest that the spontaneous recovery in infants with digenic mutations may be modulated by the above described changes. Similar mechanisms may explain the variable penetrance and tissue specificity of other mtDNA mutations and highlight the potential role of amino acids in improving mitochondrial disease.

Published
2020

58. Oral nutritional supplements for preventing surgical site infections: protocol for a systematic review and meta-analysis.

Author

Ralph, N, Brown, L, McKillop, KL, Duff, J, Osborne, S, Terry, VR, Edward, K-L, King, R, Barui, E, Ralph, N, Brown, L, McKillop, KL, Duff, J, Osborne, S, Terry, VR, Edward, K-L, King, R, and Barui, E

Abstract

Background

Surgical site infections (SSIs) are among the most common healthcare-associated infections. Under-nutrition is an important risk factor for SSIs and can lead to delayed wound healing and longer hospital stays. Oral nutritional supplements are prescribed to reduce the risk of infection and improve health status, but data from randomised controlled trials (RCTs) have shown mixed results. Thus, the objective of our planned systematic review is to evaluate oral nutritional supplements on preventing SSIs in adult surgical patients METHODS: RCTs conducted in adult surgical patients who receive oral nutritional support will be included. The primary outcome will be the incidence of SSIs (within 30 days of surgery or within 90 days for joint replacement surgery). Secondary outcomes will be changes in nutritional status, mortality, health-related quality of life and costs. Literature searches will be conducted in several electronic databases (from inception onwards): MEDLINE, Embase, CINAHL and The Cochrane Central Register of Controlled Trials (CENTRAL). Grey literature will be identified through searching clinical trial registers and dissertation databases. Two reviewers will independently screen all citations, full-text articles and abstract data. The study methodological quality (or bias) will be appraised using the Cochrane risk of bias tool. If feasible, we will conduct random effects meta-analysis where appropriate.

Discussion

This systematic review will evaluate the evidence for pre- and post-surgical intervention with oral nutritional supplements in adults. Findings from this planned review may inform subsequent nutritional interventions for hospitalised patients who undergo surgery.

Systematic review registration

PROSPERO CRD42020140954.

Published
2020

59. A unified call to action from Australian nursing and midwifery leaders: ensuring that Black lives matter

Author

Geia, L, Baird, K, Bail, K, Barclay, Lesley M, Bennett, James E, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant, R, Buzzacott, C, Campbell, S, Catling, Christine, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, Philip, Davidson, Patricia M, Denney-Wilson, Elizabeth, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, Leah, Elliott, D, Elmir, R, Fergie, D, Ferguson, Caleb, Fernandez, Ritin S, Flower, D, Foureur, M, Fowler, Cathrine, Fry, M, Gorman, E, Grant, J, Gray, Joanne, Halcomb, Elizabeth J, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, Louise, Homer, C, Hungerford, C, Hutton, A, Jackson, Debra, Johnson, A, Kelly, Margaret, Kitson, A, Knight, S, Levett-Jones, Tracy, Lindsay, D, Lovett, Raymond W, Luck, Lauretta, Molloy, Luke J, Manias, E, Mannix, Judy, Marriott, A, Martin, M, Massey, D, McCloughen, Andrea, McGough, S, McGrath, L, Mills, J, Mitchell, Brett, Mohamed, J, Montayre, J, Moroney, Tracey, Moyle, Wendy, Moxham, Lorna, Northam, H, Nowlan, S, O'Brien, A, Ogunsiji, O, Paterson, C, Pennington, K, Peters, Kathleen, Phillips, Jane, Power, Tamara, Procter, Nicholas, Ramjan, Lucie, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, Michael, Sainsbury, K, Salamonson, Yenna, Sherwood, J, Shields, L, Sim, Jenny, Skinner, J, Smallwood, G, Smallwood, R, Stewart, L, Taylor, S, Usher, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Wilkes, Lesley, Williams, R, Wilson, Rhonda, Wynaden, D, Wynne, R, Geia, L, Baird, K, Bail, K, Barclay, Lesley M, Bennett, James E, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant, R, Buzzacott, C, Campbell, S, Catling, Christine, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, Philip, Davidson, Patricia M, Denney-Wilson, Elizabeth, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, Leah, Elliott, D, Elmir, R, Fergie, D, Ferguson, Caleb, Fernandez, Ritin S, Flower, D, Foureur, M, Fowler, Cathrine, Fry, M, Gorman, E, Grant, J, Gray, Joanne, Halcomb, Elizabeth J, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, Louise, Homer, C, Hungerford, C, Hutton, A, Jackson, Debra, Johnson, A, Kelly, Margaret, Kitson, A, Knight, S, Levett-Jones, Tracy, Lindsay, D, Lovett, Raymond W, Luck, Lauretta, Molloy, Luke J, Manias, E, Mannix, Judy, Marriott, A, Martin, M, Massey, D, McCloughen, Andrea, McGough, S, McGrath, L, Mills, J, Mitchell, Brett, Mohamed, J, Montayre, J, Moroney, Tracey, Moyle, Wendy, Moxham, Lorna, Northam, H, Nowlan, S, O'Brien, A, Ogunsiji, O, Paterson, C, Pennington, K, Peters, Kathleen, Phillips, Jane, Power, Tamara, Procter, Nicholas, Ramjan, Lucie, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, Michael, Sainsbury, K, Salamonson, Yenna, Sherwood, J, Shields, L, Sim, Jenny, Skinner, J, Smallwood, G, Smallwood, R, Stewart, L, Taylor, S, Usher, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Wilkes, Lesley, Williams, R, Wilson, Rhonda, Wynaden, D, and Wynne, R

Abstract

Nurses and midwives of Australia now is the time for change! As powerfully placed, Indigenous and non-Indigenous nursing and midwifery professionals, together we can ensure an effective and robust Indigenous curriculum in our nursing and midwifery schools of education. Today, Australia finds itself in a shifting tide of social change, where the voices for better and safer health care ring out loud. Voices for justice, equity and equality reverberate across our cities, our streets, homes, and institutions of learning. It is a call for new songlines of reform. The need to embed meaningful Indigenous health curricula is stronger now than it ever was for Australian nursing and midwifery. It is essential that nursing and midwifery leadership continue to build an authentic collaborative environment for Indigenous curriculum development. Bipartisan alliance is imperative for all academic staff to be confident in their teaching and learning experiences with Indigenous health syllabus. This paper is a call out. Now is the time for Indigenous and non-Indigenous nurses and midwives to make a stand together, for justice and equity in our teaching, learning, and practice. Together we will dismantle systems, policy, and practices in health that oppress. The Black Lives Matter movement provides us with a ‘now window’ of accepted dialogue to build a better, culturally safe Australian nursing and midwifery workforce, ensuring that Black Lives Matter in all aspects of health care.

Published
2020

65. Other Virus Infections

Author

Widén, Frederik, primary, Meredith, Anna, additional, Weissenböck, Herbert, additional, Ruiz-Fons, Francisco, additional, and Duff, J. Paul, additional

Published
2012
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68. Phenocopies in a large GCH1 mutation positive family with dopa responsive dystonia: confusing the picture? (Short Report)

Author

Grimes, D.A., Barclay, C.I., Duff, J., Furukawa, Y., and Lang, A.E.

Subjects
Dopa -- Physiological aspects -- Research -- Health aspects, Familial diseases -- Research -- Health aspects -- Physiological aspects, Dystonia -- Health aspects -- Research -- Physiological aspects, Health, Psychology and mental health, Physiological aspects, Research, Health aspects
Abstract

Background: Dopa responsive dystonia (DRD) is a disorder characterised by childhood onset dystonia but a wide range of clinical presentations has now been described. Objective: To study a large Canadian [...]

Published
2002

77. HEREDITARY NEUROPATHIES & ALS

Author

Houwayek, E. El, primary, Coppens, S., additional, Topf, A., additional, Duff, J., additional, Kaleeta, J., additional, Kadhim, H., additional, Remiche, G., additional, Straub, V., additional, and Deconinck, N., additional

Published
2020
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78. Advancing the physics basis for quasi-helically symmetric stellarators

Author

Bader, A., primary, Faber, B. J., additional, Schmitt, J. C., additional, Anderson, D. T., additional, Drevlak, M., additional, Duff, J. M., additional, Frerichs, H., additional, Hegna, C. C., additional, Kruger, T. G., additional, Landreman, M., additional, McKinney, I. J., additional, Singh, L., additional, Schroeder, J. M., additional, Terry, P. W., additional, and Ware, A. S., additional

Published
2020
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79. A unified call to action from Australian nursing and midwifery leaders: ensuring that Black lives matter

Author

Geia, L., primary, Baird, K., additional, Bail, K., additional, Barclay, L., additional, Bennett, J., additional, Best, O., additional, Birks, M., additional, Blackley, L., additional, Blackman, R., additional, Bonner, A., additional, Bryant AO, R., additional, Buzzacott, C., additional, Campbell, S., additional, Catling, C., additional, Chamberlain, C., additional, Cox, L., additional, Cross, W., additional, Cruickshank, M., additional, Cummins, A., additional, Dahlen, H., additional, Daly, J., additional, Darbyshire, P., additional, Davidson, P., additional, Denney-Wilson, E., additional, De Souza, R., additional, Doyle, K., additional, Drummond, A., additional, Duff, J., additional, Duffield, C., additional, Dunning, T., additional, East, L., additional, Elliott, D., additional, Elmir, R., additional, Fergie OAM, D., additional, Ferguson, C., additional, Fernandez, R., additional, Flower AM, D., additional, Foureur, M., additional, Fowler, C., additional, Fry, M., additional, Gorman, E., additional, Grant, J., additional, Gray, J., additional, Halcomb, E., additional, Hart, B., additional, Hartz, D., additional, Hazelton, M., additional, Heaton, L., additional, Hickman, L., additional, Homer AO, C. S. E., additional, Hungerford, C., additional, Hutton, A., additional, Jackson AO, D., additional, Johnson, A., additional, Kelly, M. A., additional, Kitson, A., additional, Knight, S., additional, Levett-Jones, T., additional, Lindsay, D., additional, Lovett, R., additional, Luck, L., additional, Molloy, L., additional, Manias, E., additional, Mannix, J., additional, Marriott, A. M. R., additional, Martin, M., additional, Massey, D., additional, McCloughen, A., additional, McGough, S., additional, McGrath, L., additional, Mills, J., additional, Mitchell, B. G., additional, Mohamed, J., additional, Montayre, J., additional, Moroney, T., additional, Moyle, W., additional, Moxham, L., additional, Northam OAM, H., additional, Nowlan, S., additional, O'Brien, A. P., additional, Ogunsiji, O., additional, Paterson, C., additional, Pennington, K., additional, Peters, K., additional, Phillips, J., additional, Power, T., additional, Procter, N., additional, Ramjan, L., additional, Ramsay, N., additional, Rasmussen, B., additional, Rihari-Thomas, J., additional, Rind, B., additional, Robinson, M., additional, Roche, M., additional, Sainsbury, K., additional, Salamonson, Y., additional, Sherwood, J., additional, Shields, L., additional, Sim, J., additional, Skinner, I., additional, Smallwood, G., additional, Smallwood, R., additional, Stewart, L., additional, Taylor, S., additional, Usher AM, K., additional, Virdun, C., additional, Wannell, J., additional, Ward, R., additional, West, C., additional, West, R., additional, Wilkes, L., additional, Williams, R., additional, Wilson, R., additional, Wynaden, D., additional, and Wynne, R., additional

Published
2020
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85. Implementing a thermal care bundle for inadvertent perioperative hypothermia: A cost-effectiveness analysis

Author

Conway, A, Gow, J, Ralph, N, Duff, J, Edward, K-L, Alexander, K, Munday, J, and Bräuer, A

Subjects
Cost-Benefit Analysis, Humans, 1110 Nursing, Nursing, Hypothermia, Perioperative Period, Monte Carlo Method, Probability
Abstract

BACKGROUND: Active warming reduces risk of surgical complications. Implementation of a perioperative thermal care bundle increased use of active warming for surgical patients. OBJECTIVE: This study aimed to determine if implementing a thermal care bundle to prevent inadvertent perioperative hypothermia is cost-effective. DESIGN: A model-based cost-effectiveness analysis was undertaken using Monte Carlo simulations from input distributions to estimate costs and effects. SETTING: Hospitals undertaking between 5,000 and 40,000 surgeries per year, which either implemented or did not implement the thermal care bundle, were modelled. PARTICIPANTS: The decision tree guiding the structure of the model was populated with clinical outcomes (surgical site infection, blood transfusion requirement and morbid cardiac events) of a hypothetical cohort of surgical patients. INTERVENTIONS: Implementation or non-implementation of the thermal care bundle. MAIN OUTCOME MEASURES: Net monetary benefit was calculated by multiplying the health benefits (quality-adjusted life years) by the willingness-to-pay threshold minus the cost. We tested a range of values for willingness to pay per quality-adjusted life year thresholds and plotted results for expected incremental benefits and probability of cost-effectiveness. The incremental cost-effectiveness ratio was also calculated. RESULTS: Thermal care bundle implementation simultaneously reduced costs and increased quality-adjusted life years in the majority of simulations (88.1%). The average cost reduction was $689,659 (95% credible intervals spanned from a $2,718,364 decrease in costs to $379,826 increase in costs) and average difference in quality-adjusted life years was 54 (95% CI = 0.4 less to 176 more). This equated to an incremental cost-effectiveness ratio of $12747 saved per quality-adjusted life year gained. CONCLUSIONS: It is likely that increasing use of active warming by implementing the thermal care bundle would generate cost-savings and improve the quality of life for surgical patients. It would be good value for hospitals with similar characteristics to those included in our model to allocate the extra resources required for implementation.

Published
2019

86. Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

Author

Watson, S, Duff, J, Bardi, I, Zabielska, M, Atanur, S, Jabbour, R, Simon, A, Tomas, A, Smolenski, R, Harding, S, Terracciano, C, British Heart Foundation, and Medical Research Council (MRC)

Subjects
Adult, Male, Sarcomeres, ISOPROTERENOL, CARDIAC MYOCYTES, THERAPY, CARDIOMYOCYTES, MATURATION, TISSUE-SLICES, Rats, Sprague-Dawley, Tissue Culture Techniques, Microscopy, Electron, Transmission, Biomimetics, SKELETAL, Animals, Humans, CELL, Heart Failure, Science & Technology, Myocardium, Heart, Myocardial Contraction, Rats, Multidisciplinary Sciences, HYPERTROPHY, Science & Technology - Other Topics, RAT, Rabbits
Abstract

Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing culture-induced dedifferentiation of adult cardiac tissue using rat, rabbit and human heart failure myocardial slices. Here we report that the application of a preload equivalent to sarcomere length (SL) = 2.2 μm is optimal for the maintenance of rat myocardial slice structural, functional and transcriptional properties at 24 h. Gene sets associated with the preservation of structure and function are activated, while gene sets involved in dedifferentiation are suppressed. The maximum contractility of human heart failure myocardial slices at 24 h is also optimally maintained at SL = 2.2 μm. Rabbit myocardial slices cultured at SL = 2.2 μm remain stable for 5 days. This approach substantially prolongs the culture of adult cardiac tissue in vitro.

Published
2019

89. Zircon Petrochronology and 40Ar/39Ar Thermochronology of the Adamello Intrusive Suite, N. Italy : Monitoring the Growth and Decay of an Incrementally Assembled Magmatic System

Author

Schaltegger, U, Nowak, A, Ulianov, A, Fisher, C M, Gerdes, A, Spikings, R, Whitehouse, Martin J., Bindeman, I, Hanchar, J M, Duff, J, Vervoort, J D, Sheldrake, T, Caricchi, L, Brack, P, Müntener, O, Schaltegger, U, Nowak, A, Ulianov, A, Fisher, C M, Gerdes, A, Spikings, R, Whitehouse, Martin J., Bindeman, I, Hanchar, J M, Duff, J, Vervoort, J D, Sheldrake, T, Caricchi, L, Brack, P, and Müntener, O

Abstract

The Adamello intrusive suite is a composite batholith in Northern Italy, with an estimated 2000 km3 volume, assembled incrementally over a time span of 10 to 12 million years. The history of crystallization has been studied in detail through laser ablation ICP-MS and SIMS U–Pb geochronology of zircon, which records prolonged crystallization of each of the different intrusive units at mid-crustal levels between 43·47 and 33·16 Ma. The magmas were episodically extracted from this storage area and ascended to the final intrusion level at ∼6 km paleo-depth. Each batch of melt cooled very rapidly down to the ambient temperature of 250°C, evidenced by distinct cooling paths recorded by amphibole, biotite and K-feldspar 40Ar/39Ar dates. The magma source area was moving from SW to NE with time, causing increasing thermal maturity in the mid-crustal reservoir. The resulting temporal trend of higher degrees of crustal assimiliation in the course of the evolution of the magmatic system can be traced through Hf and O isotopes in zircon. Rough estimates of magma emplacement rates (‘magma flux’) yield very low values in the range of 10-4 km3/yr, typical of mid-to-upper crustal plutons and increase with time. Although we cannot discern a decrease of magma flux from our own data, we anticipate that a dramatic decrease of magma flux between 33 and 31 Ma along the northern contact lead to cessation of magma emplacement.

Published
2019
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90. Maternal intramuscular dexamethasone versus betamethasone before preterm birth (ASTEROID): a multicentre, double-blind, randomised controlled trial

Author

Crowther, CA, Ashwood, P, Andersen, CC, Middleton, PF, Tran, T, Doyle, LW, Robinson, JS, Harding, JE, Crowther, C, Ball, V, Holst, C, Robinson, K, Zhang, S, Robinson, J, Khong, Y, McPhee, A, Groom, K, Alsweiler, J, Eaglen, D, Hauch, H, Vallely, A, Angus, S, Chenia, F, Drew, A, Gavranich, J, Green, A, Jack, S, Mahomed, K, Sebastian, R, Turner, L, Baldwin, M, Dennis, A, Fisher, E, Gee, K, Gee, M, Strong, D, Boord, D, Edge, N, Marsh, M, Staehr, C, Chaplin, J, Gardener, G, Gray, P, Hurrion, E, Jardine, L, Kan, J, Lynn, L, Poulsen, L, Tremellen, A, Codner, T, Cubis, W, Downward, S, Dunn, C, Furey, J, Hansen, D, Lampropoulos, B, Masson, E, Peek, M, Sellar, S, Butterley, K, Chadwick, M, Davis, C, DePaoli, T, Green, L, Matzolic, T, Woodhead, G, Biggs, V, Henry, A, Lainchbury, A, Nesbitt-Hawes, E, Oei, JL, Rodrigues, C, Shand, A, Sutton, L, Welsh, A, Bowen, J, Hayes-Cameron, L, Howard, G, Jacobs, C, Milligan, J, Morris, J, Rickard, K, Sedgley, J, White-Matthews, K, Blandthorn, J, Brownfoot, F, Burnett, A, Callanan, K, Davis, N, Deluca, C, Duff, J, Howard, K, Hutchinson, E, Kelly, E, Kornman, L, Kuschel, C, Maxwell, D, McDonald, M, Poth, M, Co, J, Crowther, CA, Ashwood, P, Andersen, CC, Middleton, PF, Tran, T, Doyle, LW, Robinson, JS, Harding, JE, Crowther, C, Ball, V, Holst, C, Robinson, K, Zhang, S, Robinson, J, Khong, Y, McPhee, A, Groom, K, Alsweiler, J, Eaglen, D, Hauch, H, Vallely, A, Angus, S, Chenia, F, Drew, A, Gavranich, J, Green, A, Jack, S, Mahomed, K, Sebastian, R, Turner, L, Baldwin, M, Dennis, A, Fisher, E, Gee, K, Gee, M, Strong, D, Boord, D, Edge, N, Marsh, M, Staehr, C, Chaplin, J, Gardener, G, Gray, P, Hurrion, E, Jardine, L, Kan, J, Lynn, L, Poulsen, L, Tremellen, A, Codner, T, Cubis, W, Downward, S, Dunn, C, Furey, J, Hansen, D, Lampropoulos, B, Masson, E, Peek, M, Sellar, S, Butterley, K, Chadwick, M, Davis, C, DePaoli, T, Green, L, Matzolic, T, Woodhead, G, Biggs, V, Henry, A, Lainchbury, A, Nesbitt-Hawes, E, Oei, JL, Rodrigues, C, Shand, A, Sutton, L, Welsh, A, Bowen, J, Hayes-Cameron, L, Howard, G, Jacobs, C, Milligan, J, Morris, J, Rickard, K, Sedgley, J, White-Matthews, K, Blandthorn, J, Brownfoot, F, Burnett, A, Callanan, K, Davis, N, Deluca, C, Duff, J, Howard, K, Hutchinson, E, Kelly, E, Kornman, L, Kuschel, C, Maxwell, D, McDonald, M, Poth, M, and Co, J

Abstract

Background: Antenatal corticosteroids given to women before preterm birth improve infant survival and health. However, whether dexamethasone or betamethasone have better maternal, neonatal, and childhood health outcomes remains unclear. We therefore aimed to assess whether administration of antenatal dexamethasone to women at risk of preterm birth reduced the risk of death or neurosensory disability in their children at age 2 years compared with betamethasone. We also aimed to assess whether dexamethasone reduced neonatal morbidity, had benefits for the mother, or affected childhood body size, blood pressure, behaviour, or general health compared with betamethasone. Methods: In this multicentre, double-blind, randomised controlled trial, we recruited pregnant women from 14 maternity hospitals in Australia and New Zealand that could provide care to preterm babies. Women were eligible for study inclusion if they were at risk of preterm birth before 34 weeks of gestation, had a singleton or twin pregnancy, and had no contraindications to antenatal corticosteroids. We randomly assigned women (1:1) to receive two intramuscular injections of either 12 mg dexamethasone (dexamethasone sodium phosphate) or 11·4 mg betamethasone (Celestone Chronodose), 24 h apart. The randomisation schedule used balanced, variable blocks that were stratified by hospital, gestational age, and number of fetuses (singleton or twins). We masked all participants, staff, and assessors to treatment groups. Analyses were by intention to treat. The primary outcome was death or neurosensory disability at age 2 years (corrected for prematurity). This study is registered with ANZCTR, ACTRN12608000631303. Findings: Between Jan 28, 2009, and Feb 1, 2013, we randomly assigned 1346 (78%) women who were pregnant with 1509 fetuses to groups: 679 (50%) women were assigned to receive dexamethasone and 667 (50%) women were assigned to receive betamethasone. 27 (4%) fetuses, infants, or children in the dexamethaso

Published
2019

91. Identifying nurses perceived enablers and barriers to providing evidence-based, best practice urinary continence assessment and management: A cross-sectional study

Author

Boyle, K, Jordan, L, Dunne, J, Shipp, J, Minett, F, Styles, A, Ormond, S, Buzio, A, Parrey, K, Lever, S, Paul, M, Hill, K, Cadilhac, D, Pollack, M, Duff, J., Marsden, D, Boyle, K, Jordan, L, Dunne, J, Shipp, J, Minett, F, Styles, A, Ormond, S, Buzio, A, Parrey, K, Lever, S, Paul, M, Hill, K, Cadilhac, D, Pollack, M, Duff, J., and Marsden, D

Published
2019

92. Fixing a wee problem – will the SCAMP (Structured urinary Continence Assessment and Management Plan) intervention make a difference? – study protocol

Author

Marsden, D, Boyle, K, Jordan, L, Dunne, J, Shipp, J, Minett, F, Styles, A, Ormond, S, Buzio, A, Parrey, K, Lever, S, Paul, M, Hill, K, Cadilhac, D, Duff, J., Pollack, M, Marsden, D, Boyle, K, Jordan, L, Dunne, J, Shipp, J, Minett, F, Styles, A, Ormond, S, Buzio, A, Parrey, K, Lever, S, Paul, M, Hill, K, Cadilhac, D, Duff, J., and Pollack, M

Abstract

Background Urinary incontinence has negative effects for patients and health systems. In recent Stroke Foundation audits, nationally 35% of acute and 41% of rehabilitation inpatients had urinary incontinence, but only half had associated management plans. Aim To determine if broader implementation (multiple Health Districts, across phases of care) of our previously-piloted multidisciplinary Structured urinary Continence Assessment and Management Plan (SCAMP) interventions (including clinically-applicable tools, processes and education; audit and feedback) improves inpatient post-stroke urinary incontinence assessment, diagnosis and management. Methods Design: before- and after-implementation study at six acute stroke/ medical units, two comprehensive stroke and six rehabilitation services in three New South Wales Local Health Districts.Primary outcome: change in the proportion of incontinent patients who have a continence management plan.Secondary outcomes: change in the proportion of patients who have a urinary continence assessment, documented incontinence diagnosis and receive continence education. We will also determine the intervention effect on clinician knowledge, skills and confidence, and potential cost-effectiveness (hospital perspective).Data collection: medical record audits, clinician questionnaires and site-specific teams identifying local barriers and enablers to continence management. Data will be collected for 3 months before and after the 7-month implementation period. Sustainability will be evaluated 16 months after implementation commences.Results Ethics is approved. Before-implementation data collection commenced January 2019. The project will be completed by July 2020. Discussion Our SCAMP interventions can potentially operationalise high-level concepts outlined in Australian stroke guidelines into effective clinical care across hospitals a

Published
2019

93. Improving in-hospital post-stroke urinary continence assessment and management by implementing the 'Structured Urinary Continence Assessment and Management Plan (SCAMP)'- the study protocol

Author

Marsden, D, Boyle, K, Jordan, L, Dunne, J, Shipp, J, Minett, F, Styles, A, Ormond, S, Buzio, A, Parrey, K, Lever, S, Paul, M, Hill, K, Cadilhac, D, Duff, J., Pollack, M, Marsden, D, Boyle, K, Jordan, L, Dunne, J, Shipp, J, Minett, F, Styles, A, Ormond, S, Buzio, A, Parrey, K, Lever, S, Paul, M, Hill, K, Cadilhac, D, Duff, J., and Pollack, M

Abstract

Background and Aims:Urinary incontinence is a common, costly but often overlooked stroke complication. We aim to determine if implementing our SCAMP intervention (includes previously-piloted clinically-applicable tools and processes and education, audit and feedback) improves urinary incontinence assessment and management for in-hospital patients following stroke. Methods:Design: pragmatic, before- and after-implementation study at six acute stroke/ medical units, two comprehensive stroke and six rehabilitation services in NSW, Australia. Primary outcome: change in the proportion of incontinent patients who have a continence management plan. Secondary outcomes: change in the proportion of patients who have a urinary continence assessment, recorded diagnosis of incontinence type/s, and receive continence education. We will also determine the intervention effect on clinician knowledge, skills and confidence, and the potential cost-effectiveness from a hospital perspective. Data collection: medical record audits, clinician questionnaires and site-specific teams identifying local barriers and enablers to continence management. Data will be collected for 3 months before and after the 7-month implementation period. To assess sustainability, outcomes will again be measured 16 months after implementation commences. Fifteen consecutive medical record audits (incontinent patients) per site per month will provide >80% power to detect a 20% absolute increase (from before intervention) in the proportion of incontinent patients with an incontinence plan (type 1 error rate of 5%). Results:Ethics has been approved. Before-implementation data collection is underway. The project will be completed by July 2020. Conclusions:We will translate high-level concepts outlined in clinical guidelines into effective and efficient continence care. SCAMP has the potential to be read

Published
2019

94. Impact of extreme prematurity or extreme low birth weight on young adult health and well-being: the Victorian Infant Collaborative Study (VICS) 1991-1992 Longitudinal Cohort study protocol

Author

Cheong, JLY, Wark, JD, Cheung, MM, Irving, L, Burnett, AC, Lee, KJ, Garland, SM, Smallwood, D, Patton, GC, Haikerwal, A, Doyle, LW, Cheong, J, Anderson, C, Anderson, P, Bear, M, Boland, R, Burnett, A, Callanan, C, Carse, E, Charlton, M, Clarke, M, Courtot, J, Davis, N, Doyle, L, Duff, J, Ellis, R, Hickey, L, Hayes, M, Josev, E, Kelly, E, McDonald, M, McInnes, E, Novella, B, Olsen, J, Opie, G, Roberts, G, Scott, K, Spittle, A, Stevens, P, Turner, A-M, Cheong, JLY, Wark, JD, Cheung, MM, Irving, L, Burnett, AC, Lee, KJ, Garland, SM, Smallwood, D, Patton, GC, Haikerwal, A, Doyle, LW, Cheong, J, Anderson, C, Anderson, P, Bear, M, Boland, R, Burnett, A, Callanan, C, Carse, E, Charlton, M, Clarke, M, Courtot, J, Davis, N, Doyle, L, Duff, J, Ellis, R, Hickey, L, Hayes, M, Josev, E, Kelly, E, McDonald, M, McInnes, E, Novella, B, Olsen, J, Opie, G, Roberts, G, Scott, K, Spittle, A, Stevens, P, and Turner, A-M

Abstract

INTRODUCTION: Infants born extremely preterm (EP, <28 weeks' gestation) or with extremely low birth weight (ELBW,<1000 g) in the era when surfactant has been available clinically are at high risk of health and developmental problems in childhood and adolescence. However, how their health and well-being may be affected in adulthood is not well known. This study aims to compare between EP/ELBW and normal birthweight (NBW) controls: (1) physical health, mental health and socioemotional functioning at 25 years of age and (2) trajectories of these outcomes from childhood to adulthood. In addition, this study aims to identify risk factors in pregnancy, infancy, childhood and adolescence for poor physical health and well-being in EP/ELBW young adults. METHODS AND ANALYSIS: The Victorian Infant Collaborative Study (VICS) is a prospective geographical cohort of all EP/ELBW survivors to 18 years of age born in the State of Victoria, Australia, from 1 January 1991 to 31 December 1992 (n=297) and contemporaneous term-born/NBW controls (n=262). Participants were recruited at birth and followed up at 2, 5, 8 and 18 years. This 25-year follow-up includes assessments of physical health (cardiovascular, respiratory and musculoskeletal), mental health and socioemotional functioning. Outcomes will be compared between the birth groups using linear and logistic regression, fitted using generalised estimating equations (GEEs). Trajectories of health outcomes from early childhood will be compared between the birth groups using linear mixed-effects models. Risk factors for adult outcomes will be assessed using linear and logistic regression (fitted using GEEs). ETHICS AND DISSEMINATION: This study was approved by the Human Research Ethics Committees of the Royal Women's Hospital, Mercy Hospital for Women, Monash Medical Centre and the Royal Children's Hospital, Melbourne. Study outcomes will be disseminated through conference presentations, peer-reviewed publications, the internet and soci

Published
2019

95. 2019 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations: Summary from the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; And First Aid Task Forces

Author

Soar, J., Maconochie, I., Wyckoff, M. H., Olasveengen, T. M., Singletary, E. M., Greif, R., Aickin, R., Bhanji, F., Donnino, M. W., Mancini, M. E., Wyllie, J. P., Zideman, D., Andersen, L. W., Atkins, D. L., Aziz, K., Bendall, J., Berg, K. M., Berry, D. C., Bigham, B. L., Bingham, R., Couto, T. B., Bottiger, B. W., Borra, V., Bray, J. E., Breckwoldt, J., Brooks, S. C., Buick, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Cheng, A., Chung, S. P., Considine, J., Couper, K., Dainty, K. N., Dawson, J. A., De Almeida, M. F., De Caen, A. R., Deakin, C. D., Drennan, I. R., Duff, J. P., Epstein, J. L., Escalante, R., Gazmuri, R. J., Gilfoyle, E., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Holmberg, M. J., Hood, N., Hosono, S., Hsieh, M. -J., Isayama, T., Iwami, T., Jensen, J. L., Kapadia, V., Kim, H. -S., Kleinman, M. E., Kudenchuk, P. J., Lang, E., Lavonas, E., Liley, H., Lim, S. H., Lockey, A., Lofgren, B., Ma, M. H. -M., Markenson, D., Meaney, P. A., Meyran, D., Mildenhall, L., Monsieurs, K. G., Montgomery, W., Morley, P. T., Morrison, L. J., Nadkarni, V. M., Nation, K., Neumar, R. W., Ng, K. -C., Nicholson, T., Nikolaou, N., Nishiyama, C., Nuthall, G., Ohshimo, S., Okamoto, D., O'Neil, B., Yong-Kwang Ong, G., Paiva, E. F., Parr, M., Pellegrino, J. L., Perkins, G. D., Perlman, J., Rabi, Y., Reis, A., Reynolds, J. C., Ristagno, G., Roehr, C. C., Sakamoto, T., Sandroni, Claudio, Schexnayder, S. M., Scholefield, B. R., Shimizu, N., Skrifvars, M. B., Smyth, M. A., Stanton, D., Swain, J., Szyld, E., Tijssen, J., Travers, A., Trevisanuto, D., Vaillancourt, C., Van De Voorde, P., Velaphi, S., Wang, T. -L., Weiner, G., Welsford, M., Woodin, J. A., Yeung, J., Nolan, J. P., Fran Hazinski, M., Sandroni C. (ORCID:0000-0002-8878-2611), Soar, J., Maconochie, I., Wyckoff, M. H., Olasveengen, T. M., Singletary, E. M., Greif, R., Aickin, R., Bhanji, F., Donnino, M. W., Mancini, M. E., Wyllie, J. P., Zideman, D., Andersen, L. W., Atkins, D. L., Aziz, K., Bendall, J., Berg, K. M., Berry, D. C., Bigham, B. L., Bingham, R., Couto, T. B., Bottiger, B. W., Borra, V., Bray, J. E., Breckwoldt, J., Brooks, S. C., Buick, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Cheng, A., Chung, S. P., Considine, J., Couper, K., Dainty, K. N., Dawson, J. A., De Almeida, M. F., De Caen, A. R., Deakin, C. D., Drennan, I. R., Duff, J. P., Epstein, J. L., Escalante, R., Gazmuri, R. J., Gilfoyle, E., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Holmberg, M. J., Hood, N., Hosono, S., Hsieh, M. -J., Isayama, T., Iwami, T., Jensen, J. L., Kapadia, V., Kim, H. -S., Kleinman, M. E., Kudenchuk, P. J., Lang, E., Lavonas, E., Liley, H., Lim, S. H., Lockey, A., Lofgren, B., Ma, M. H. -M., Markenson, D., Meaney, P. A., Meyran, D., Mildenhall, L., Monsieurs, K. G., Montgomery, W., Morley, P. T., Morrison, L. J., Nadkarni, V. M., Nation, K., Neumar, R. W., Ng, K. -C., Nicholson, T., Nikolaou, N., Nishiyama, C., Nuthall, G., Ohshimo, S., Okamoto, D., O'Neil, B., Yong-Kwang Ong, G., Paiva, E. F., Parr, M., Pellegrino, J. L., Perkins, G. D., Perlman, J., Rabi, Y., Reis, A., Reynolds, J. C., Ristagno, G., Roehr, C. C., Sakamoto, T., Sandroni, Claudio, Schexnayder, S. M., Scholefield, B. R., Shimizu, N., Skrifvars, M. B., Smyth, M. A., Stanton, D., Swain, J., Szyld, E., Tijssen, J., Travers, A., Trevisanuto, D., Vaillancourt, C., Van De Voorde, P., Velaphi, S., Wang, T. -L., Weiner, G., Welsford, M., Woodin, J. A., Yeung, J., Nolan, J. P., Fran Hazinski, M., and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research.

Published
2019

96. 2019 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Author

Soar, J., Maconochie, I., Wyckoff, M. H., Olasveengen, T. M., Singletary, E. M., Greif, R., Aickin, R., Bhanji, F., Donnino, M. W., Mancini, M. E., Wyllie, J. P., Zideman, D., Andersen, L. W., Atkins, D. L., Aziz, K., Bendall, J., Berg, K. M., Berry, D. C., Bigham, B. L., Bingham, R., Couto, T. B., Bottiger, B. W., Borra, V., Bray, J. E., Breckwoldt, J., Brooks, S. C., Buick, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Cheng, A., Chung, S. P., Considine, J., Couper, K., Dainty, K. N., Dawson, J. A., de Almeida, M. F., de Caen, A. R., Deakin, C. D., Drennan, I. R., Duff, J. P., Epstein, J. L., Escalante, R., Gazmuri, R. J., Gilfoyle, E., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Holmberg, M. J., Hood, N., Hosono, S., Hsieh, M. -J., Isayama, T., Iwami, T., Jensen, J. L., Kapadia, V., Kim, H. -S., Kleinman, M. E., Kudenchuk, P. J., Lang, E., Lavonas, E., Liley, H., Lim, S. H., Lockey, A., Lofgren, B., Ma, M. H. -M., Markenson, D., Meaney, P. A., Meyran, D., Mildenhall, L., Monsieurs, K. G., Montgomery, W., Morley, P. T., Morrison, L. J., Nadkarni, V. M., Nation, K., Neumar, R. W., Ng, K. -C., Nicholson, T., Nikolaou, N., Nishiyama, C., Nuthall, G., Ohshimo, S., Okamoto, D., O'Neil, B., Ong, G. Y. -K., Paiva, E. F., Parr, M., Pellegrino, J. L., Perkins, G. D., Perlman, J., Rabi, Y., Reis, A., Reynolds, J. C., Ristagno, G., Roehr, C. C., Sakamoto, T., Sandroni, C., Schexnayder, S. M., Scholefield, B. R., Shimizu, N., Skrifvars, M. B., Smyth, M. A., Stanton, D., Swain, J., Szyld, E., Tijssen, J., Travers, A., Trevisanuto, D., Vaillancourt, C., Van de Voorde, P., Velaphi, S., Wang, T. -L., Weiner, G., Welsford, M., Woodin, J. A., Yeung, J., Nolan, J. P., Hazinski, M. F., Sandroni C. (ORCID:0000-0002-8878-2611), Soar, J., Maconochie, I., Wyckoff, M. H., Olasveengen, T. M., Singletary, E. M., Greif, R., Aickin, R., Bhanji, F., Donnino, M. W., Mancini, M. E., Wyllie, J. P., Zideman, D., Andersen, L. W., Atkins, D. L., Aziz, K., Bendall, J., Berg, K. M., Berry, D. C., Bigham, B. L., Bingham, R., Couto, T. B., Bottiger, B. W., Borra, V., Bray, J. E., Breckwoldt, J., Brooks, S. C., Buick, J., Callaway, C. W., Carlson, J. N., Cassan, P., Castren, M., Chang, W. -T., Charlton, N. P., Cheng, A., Chung, S. P., Considine, J., Couper, K., Dainty, K. N., Dawson, J. A., de Almeida, M. F., de Caen, A. R., Deakin, C. D., Drennan, I. R., Duff, J. P., Epstein, J. L., Escalante, R., Gazmuri, R. J., Gilfoyle, E., Granfeldt, A., Guerguerian, A. -M., Guinsburg, R., Hatanaka, T., Holmberg, M. J., Hood, N., Hosono, S., Hsieh, M. -J., Isayama, T., Iwami, T., Jensen, J. L., Kapadia, V., Kim, H. -S., Kleinman, M. E., Kudenchuk, P. J., Lang, E., Lavonas, E., Liley, H., Lim, S. H., Lockey, A., Lofgren, B., Ma, M. H. -M., Markenson, D., Meaney, P. A., Meyran, D., Mildenhall, L., Monsieurs, K. G., Montgomery, W., Morley, P. T., Morrison, L. J., Nadkarni, V. M., Nation, K., Neumar, R. W., Ng, K. -C., Nicholson, T., Nikolaou, N., Nishiyama, C., Nuthall, G., Ohshimo, S., Okamoto, D., O'Neil, B., Ong, G. Y. -K., Paiva, E. F., Parr, M., Pellegrino, J. L., Perkins, G. D., Perlman, J., Rabi, Y., Reis, A., Reynolds, J. C., Ristagno, G., Roehr, C. C., Sakamoto, T., Sandroni, C., Schexnayder, S. M., Scholefield, B. R., Shimizu, N., Skrifvars, M. B., Smyth, M. A., Stanton, D., Swain, J., Szyld, E., Tijssen, J., Travers, A., Trevisanuto, D., Vaillancourt, C., Van de Voorde, P., Velaphi, S., Wang, T. -L., Weiner, G., Welsford, M., Woodin, J. A., Yeung, J., Nolan, J. P., Hazinski, M. F., and Sandroni C. (ORCID:0000-0002-8878-2611)

Abstract

The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research.

Published
2019

99. Heat stress regulates the human 70-kDa heat-shock gene through the 3'-untranslated region

Author

Moseley, Pope L., Wallen, Erik S., McCafferty, Duff J., Flanagan, Shawn, and Kern, Jeffrey A.

Subjects
Heat shock proteins -- Influence, Cell research -- Observations, Biological sciences
Abstract

The synthesis of a group of proteins, called heat shock proteins (HSP), by cells, enable the cells to respond to different kinds of stresses. The posttranscriptional regulation of protein production involves the 3'-untranslated regions (UTR's) for the mRNAs. Through the HSP7O 3'-UTR, the heat regulates the HSP7O production, in addition to the known effects on transcription. Plasmids containing sequences, encoding the human HSP70 or beta globin 3'-UTR, were used in the transfection of the cells. The transfection identifies a heat induced mechanism of posttranscriptional control of HSP70 synthesis.

Published
1993

100. Successful small-bowel/liver transplantation

Author

Grant, D., Wall, W., Mimeault, R., Zhong, R., Ghent, C., Garcia, B., Stiller, C., and Duff, J.

Subjects
Cyclosporine -- Health aspects, Malabsorption syndromes, Intestines, Liver -- Transplantation, Transplantation of organs, tissues, etc. -- Case studies
Published
1990

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