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52. Evaluation of the University of Florida lomustine, vincristine, procarbazine, and prednisone chemotherapy protocol for the treatment of relapsed lymphoma in dogs: 33 cases (2003–2009)

Author

Christine E. Fahey, David M. Lurie, Shannon Parfitt, Kelvin Kow, Karri Barabas, Rowan J. Milner, Sarah E. Lyles, and Monica Clemente

Subjects
medicine.medical_specialty, Vincristine, Lymphoma, Procarbazine, Gastroenterology, Dogs, Lomustine, Recurrence, Prednisone, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Dog Diseases, Retrospective Studies, General Veterinary, business.industry, Induction chemotherapy, medicine.disease, Surgery, Discontinuation, Drug Resistance, Neoplasm, Toxicity, business, medicine.drug
Abstract

Objective—To evaluate the toxicity and efficacy of a modification of a previously evaluated combination of lomustine, vincristine, procarbazine, and prednisone (LOPP) as a rescue protocol for refractory lymphoma in dogs. Design—Retrospective case series. Animals—33 dogs with a cytologic or histologic diagnosis of lymphoma that developed resistance to their induction chemotherapy protocol. Procedures—Lomustine was administered on day 0 of the protocol. Vincristine was administered on day 0 and again 1 time on day 14. Procarbazine and prednisone were administered on days 0 through 13 of the protocol. This cycle was repeated every 28 days. Results—Median time from initiation to discontinuation of the University of Florida LOPP protocol was 84 days (range, 10 to 308 days). Overall median survival time was 290 days (range, 51 to 762 days). Overall response rate with this protocol was 61% (20/33), with 36% (12) having a complete response and 24% (8) having a partial response. Toxicosis rates were lower than for the previously published LOPP protocol. Conclusions and Clinical Relevance—The University of Florida LOPP protocol may be an acceptable alternative to the mechlorethamine, vincristine, procarbazine, and prednisone protocol as a rescue protocol for dogs with lymphoma.

Published
2011
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53. Lateral Transfer Recirculating Etalon Receiver for Methane Spectroscopy

Author

Molly E. Fahey and Mark A. Stephen

Subjects
Materials science, Spectrometer, business.industry, Wavelength channels, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Methane, 010309 optics, chemistry.chemical_compound, Optics, Transmission (telecommunications), chemistry, Transfer (computing), 0103 physical sciences, 0210 nano-technology, Absorption (electromagnetic radiation), Spectroscopy, business, Fabry–Pérot interferometer
Abstract

We describe an etalon spectrometer with a novel light recirculation scheme to generate simultaneous parallel wavelength channels with no moving parts. We present results from a system to resolve the 1651 nm absorption feature of methane. We present results from a prototype and a corresponding model. We also show results from a solid, 3-mirror etalon that has >95% peak transmission and significantly better out-of-band rejection than its 2-mirror counterpart. We show application of this system to methane laser spectroscopy.

Published
2016
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54. Non- Topographic Space-Based Laser Remote Sensing

Author

Oleg A. Konoplev, Anthony W. Yu, Haris Riris, Stewart Wu, Molly E. Fahey, Kenji Numata, Mark A. Stephen, Michael E. Purucker, Stephanie Getty, Jeffrey R. Chen, Diego Janches, James B. Abshire, Graham R. Allan, Steve Li, and Michael A. Krainak

Subjects
Atmosphere, Lidar, Remote sensing (archaeology), law, Orbit of Mars, Global warming, Environmental science, Natural satellite, Mars Exploration Program, Laser, Remote sensing, law.invention
Abstract

The advent of several key enabling electro-optics technologies afford advanced, non-topographic remote sensing instruments for space. We will present progress on several new, space-based laser instruments that are being developed at NASA GSFC. Long Abstract: In the past 20+ years, NASA Goddard Space Flight Center (GSFC) has successfully developed and flown lidars for mapping of Mars, the Earth, Mercury and the Moon. As laser and electro-optics technologies expand and mature, more sophisticated instruments that once were thought to be too complicated for space are being considered and developed. We will present progress on several new, space-based laser instruments that are being developed at GSFC. These include lidars for remote sensing of carbon dioxide and methane on Earth for carbon cycle and global climate change; sodium resonance fluorescence lidar to measure environmental parameters of the middle and upper atmosphere on Earth and Mars and a wind lidar for Mars orbit; in situ laser instruments include remote and in-situ measurements of the magnetic fields; and a time-of-flight mass spectrometer to study the diversity and structure of nonvolatile organics in solid samples on missions to outer planetary satellites and small bodies.

Published
2016
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55. Gene Expression, Intron Density, and Splice Site Strength in Drosophila and Caenorhabditis

Author

Marie E. Fahey and Desmond G. Higgins

Subjects
Genetics, Base Composition, Splice site mutation, Base Sequence, biology, Alternative splicing, Intron, Chromosome Mapping, Gene Expression, Group II intron, biology.organism_classification, Introns, Caenorhabditis, Drosophila melanogaster, RNA splicing, Animals, RNA Splice Sites, Caenorhabditis elegans, Molecular Biology, Ecology, Evolution, Behavior and Systematics
Abstract

In this paper we investigate the relationships among intron density (number of introns per kilobase of coding sequence), gene expression level, and strength of splicing signals in two species: Drosophila melanogaster and Caenorhabditis elegans. We report a negative correlation between intron density and gene expression levels, opposite to the effect previously observed in human. An increase in splice site strength has been observed in long introns in D. melanogaster. We show this is also true of C. elegans. We also examine the relationship between intron density and splice site strength. There is an increase in splice site strength as the intron structure becomes less dense. This could suggest that introns are not recognized in isolation but could function in a cooperative manner to ensure proper splicing. This effect remains if we control for the effects of alternative splicing on splice site strength.

Published
2007
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56. Plasma ammonia concentration after L-asparaginase therapy in 27 dogs with high-grade lymphoma or leukemia

Author

Abbie L, Speas, Sarah E, Lyles, Kimberly A, Wirth, Christine E, Fahey, Kelvin, Kow, Amandine T, Lejeune, and Rowan J, Milner

Subjects
Male, Leukemia, Lymphoma, Non-Hodgkin, Antineoplastic Agents, Dogs, Ammonia, Risk Factors, Case-Control Studies, Animals, Asparaginase, Humans, Hyperammonemia, Female, Prospective Studies
Abstract

To establish the occurrence of increased plasma ammonia concentration after L-asparaginase (L-asp) administration in dogs with high-grade lymphoma or leukemia; to identify risk factors for the development of hyperammonemia after L-asp administration; and to determine occurrence of adverse events related to hyperammonemia.Prospective case controlled study of sequentially enrolled dogs between May 2011 and March 2012.A university veterinary teaching hospital.Twenty-seven dogs with high-grade lymphoma or leukemia.All dogs received L-asp intramuscularly at a median dose of 400 IU/kg.Plasma ammonia concentrations were measured at baseline, 16 hours, and 48 hours after L-asp therapy. Clinicopathological abnormalities were assessed to determine risk factors for the development of hyperammonemia. Adverse events following L-asp were recorded. Median plasma ammonia concentrations at baseline, 16 hours, and 48 hours were 26 μmol/L (44 μg/dL), 98 μmol/L (166.9 μg/dL), and 67 μmol/L (114 μg/dL), respectively. Median plasma ammonia concentrations at 16 and 48 hours after administration were significantly increased compared to baseline. Six dogs had adverse events following L-asp administration. No significant clinical signs were noted that could clearly be attributed to hyperammonemia. No risk factors for developing hyperammonemia were identified; however, there was a positive correlation between the development of hyperammonemia at 16- and 48-hour time points.Subclinical hyperammonemia in dogs with lymphoma or leukemia after L-asp administration appears to be common. No risk factors were identified for the development of hyperammonemia after L-asp treatment, and severe adverse events were rare.

Published
2015

57. Lateral-transfer recirculating etalon spectrometer

Author

Michael A. Krainak, Mark A. Stephen, and Molly E. Fahey

Subjects
Physics, Photon, Optics, Spectrometer, business.industry, Transfer (computing), Wavelength-division multiplexing, Resolution (electron density), Wavelength channels, business, Atomic and Molecular Physics, and Optics, Fabry–Pérot interferometer, Free-space optical communication
Abstract

We describe a Fabry-Perot etalon spectrometer with a novel light recirculation scheme to generate simultaneous parallel wavelength channels with no moving parts. This design uses very simple optics to recirculate light reflected from near normal incidence from the etalon at successively higher angles of incidence. The spectrometer has the full resolution of a Fabry-Perot with significantly improved photon efficiency in a compact, simple design with no moving parts. We present results from a conceptual prototype and a corresponding model.

Published
2015

58. Overlapping Antisense Transcription in the Human Genome

Author

Marie E. Fahey, Desmond G. Higgins, and Tom Moore

Subjects
Genetics, Regulation of gene expression, lcsh:QH426-470, Locus (genetics), Biology, Antisense RNA, lcsh:Genetics, lcsh:Biology (General), Transcription (biology), Sense (molecular biology), RefSeq, lcsh:Q, Human genome, lcsh:Science, lcsh:QH301-705.5, Molecular Biology, Overlapping gene, Research Article, Biotechnology
Abstract

Accumulating evidence indicates an important role for non-coding RNA molecules in eukaryotic cell regulation. A small number of coding and non-coding overlapping antisense transcripts (OATs) in eukaryotes have been reported, some of which regulate expression of the corresponding sense transcript. The prevalence of this phenomenon is unknown, but there may be an enrichment of such transcripts at imprinted gene loci. Taking a bioinformatics approach, we systematically searched a human mRNA database (RefSeq) for complementary regions that might facilitate pairing with other transcripts. We report 56 pairs of overlapping transcripts, in which each member of the pair is transcribed from the same locus. This allows us to make an estimate of 1000 for the minimum number of such transcript pairs in the entire human genome. This is a surprisingly large number of overlapping gene pairs and, clearly, some of the overlaps may not be functionally significant. Nonetheless, this may indicate an important general role for overlapping antisense control in gene regulation. EST databases were also investigated in order to address the prevalence of cases of imprinted genes with associated non-coding overlapping, antisense transcripts. However, EST databases were found to be completely inappropriate for this purpose.

Published
2002
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59. Abstract 1743: Comprehensive genomic characterization of a large cohort of platinum-sensitive, high-grade serous ovarian cancer (HGSOC) FFPE specimens

Author

Charles Schweizer, Gary J. Latham, Daniel J. O'Shannessy, Darcy Myers, Nicholas C. Nicolaides, Elizabeth B. Somers, Diane Ilsley, Marie E. Fahey, and Brian C. Haynes

Subjects
Oncology, Cancer Research, medicine.medical_specialty, business.industry, Internal medicine, medicine, Serous ovarian cancer, Platinum sensitive, business, Large cohort
Abstract

Introduction: Ovarian cancer is a leading cause of cancer related death in women. A comprehensive genomic characterization of platinum-sensitive tumors is required to further refine the definition of molecular subtypes and identify targeted therapies for this patient population. To this end we have performed a large-scale genomic and transcriptomic characterization of 348 primary FFPE tissues from a cohort of platinum-sensitive HGSOC patients collected from multiple clinical sites. Methods: Macrodissection of FFPE resected tumor slides or sectioned blocks was performed to enrich for tumor content. RNA and DNA were each isolated from 2x 5µm sections of FFPE material. RNA expression and gene fusions were profiled by whole transcriptome RNA-Seq. DNA variants were analyzed by the AmpliSeq™ Cancer Hotspot Panel (Thermo Fisher). A subset of tumor and matched germline (PBL) specimens (N=181) were assessed for TP53 mutations by the QuantideX® NGS TP53 Assay (Asuragen, Inc.). CNV analysis of FFPE tumor DNA was performed using the OncoScan® FFPE Assay Kit (Affymetrix) and microsatellite instability was characterized by comparing matched tumor and PBL specimens with capillary electrophoresis using the Bethesda panel. Germline BRCA1/2 mutation status was determined by profiling PBL specimens with a custom AmpliSeq™ NGS panel. Results: The spectrum of DNA mutations and CNVs was consistent with other HGSOC cohorts with mutations in TP53 present in the majority of specimens (87% for specimens with full exon coverage of TP53). Germline mutations in BRCA1 and BRCA2 were identified at 10.3% and 6.8% respectively. Analysis of recurrent whole chromosomal arm gain and loss displayed a striking agreement with the TCGA HGSOC cohort. Unsupervised analysis of the RNA-Seq expression data through non-negative matrix factorization revealed 4 distinct transcriptional subtypes, corresponding to the 4 established CLOVAR subtypes: differentiated, immunoreactive, mesenchymal and proliferative. Patients classified as mesenchymal had the poorest prognosis. Further integrative analysis identified additional associations between the CLOVAR subtypes and other molecular indications. Conclusions: Through integrative genomic analyses on this challenging set of clinical specimens we have reproduced and refined the molecular subtypes of platinum-sensitive HGSOC and highlighted alterations that may lead to improved diagnostic and precision medicine strategies. In contrast to previous large-scale molecular characterization efforts such as TCGA where fresh-frozen tissues were collected under highly controlled settings, this study is based on molecular profiling of FFPE tissues collected at dozens of clinical sites. Thus, our study serves as a model for future molecular characterization efforts of FFPE specimens collected in real-world clinical settings. Citation Format: Brian C. Haynes, Marie E. Fahey, Darcy Myers, Diane Ilsley, Gary J. Latham, Elizabeth B. Somers, Nicholas C. Nicolaides, Charles Schweizer, Daniel J. O’Shannessy. Comprehensive genomic characterization of a large cohort of platinum-sensitive, high-grade serous ovarian cancer (HGSOC) FFPE specimens [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1743. doi:10.1158/1538-7445.AM2017-1743

Published
2017
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60. NMR studies of hydrogen bonding interactions with secondary amide and urea groups

Author

Bradley D. Smith, Martin J. Deetz, and Julianne E. Fahey

Subjects
Hydrogen bond, Chemistry, Organic Chemistry, Intermolecular force, Low-barrier hydrogen bond, Nuclear magnetic resonance spectroscopy, Medicinal chemistry, Bond order, chemistry.chemical_compound, Amide, Proton NMR, Organic chemistry, Physical and Theoretical Chemistry, Conformational isomerism
Abstract

The cis/trans ratios for six model secondary amides were determined by 1H NMR in a range of solvent systems. The trans to cis equilibrium in chloroform is only slightly affected by addition of the hydrogen bond donor, trifluorethanol, but the cis rotamer is stabilized by an average of 0.7 kcal mol−1 when acetic acid is used as an intermolecular donor–acceptor template. Conversely, amide interaction with anionic hydrogen bond acceptors decreases the percentage of cis rotamer. 15N NMR spectroscopy was used to determine the effect of hydrogen bonding on the trans amide structure. The direction and the magnitude of 15N complex-induced-shifts indicate that both hydrogen bond donors and acceptors raise the secondary amide rotational barrier by increasing the CN bond order. The relationship of these results to protein structure is discussed. Copyright © 2001 John Wiley & Sons, Ltd.

Published
2001
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62. Infrared materials for thermophotovoltaic applications

Author

G. W. Charache, J. L. Egley, D. M. Depoy, L. R. Danielson, M. J. Freeman, R. J. Dziendziel, J. F. Moynihan, P. F. Baldasaro, B. C. Campbell, C. A. Wang, H. K. Choi, G. W. Turner, S. J. Wojtczuk, P. Colter, P. Sharps, M. Timmons, R. E. Fahey, and K. Zhang

Subjects
Interference filter, Materials science, business.industry, Open-circuit voltage, Band gap, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Semiconductor, Thermophotovoltaic, Materials Chemistry, Energy transformation, Optoelectronics, Quantum efficiency, Electrical and Electronic Engineering, business, Diode
Abstract

Thermophotovoltaic generation of electricity is attracting renewed attention due to recent advances in low bandgap (0.5–0.7 eV) III-V semiconductors. The use of these devices in a number of applications has been reviewed in a number of publications.1–4 Two potential low-bandgap diode materials are InxGa1−xAsySb1−y and InxGa1−xAs. The performance of these devices are comparable (quantum efficiency, open circuit voltage, fill factor) despite the latter’s long-term development for optoelectronics. For an 1100°C blackbody, nominally 0.55 eV devices at 25°C exhibit average photon-weighted internal quantum efficiencies of 70–80%, open circuit voltage factors of 60–65%, and fill factors of 65–70%. Equally important as the energy conversion device is the spectral control filter that effectively transmits above bandgap radiation into the diode and reflects the below bandgap radiation back to the radiator. Recent developments in spectral control technology, including InGaAs plasma filters and nonabsorbing interference filters are presented. Current tandem filters exhibit spectral utilization factors of ∼65% for an 1100°C blackbody.

Published
1998
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63. Apoptotic effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine osteosarcoma cells

Author

Nicholas J. Bacon, Christine E. Fahey, Kelvin Kow, Marc E. Salute, and Rowan J. Milner

Subjects
Vascular Endothelial Growth Factor A, Cancer Research, medicine.drug_class, Cell Survival, Pyridines, Antineoplastic Agents, Apoptosis, Bone Neoplasms, Canine Osteosarcoma, Tyrosine-kinase inhibitor, Dogs, Piperidines, Cell Line, Tumor, medicine, Animals, Pharmacology (medical), Protein Kinase Inhibitors, Pharmacology, Osteosarcoma, Dose-Response Relationship, Drug, business.industry, medicine.disease, Highly selective, Thiazoles, Primary bone, Oncology, Benzamides, Cancer research, Masitinib mesylate, business, Guarded prognosis
Abstract

Osteosarcoma (OSA) is the most common primary bone tumor in dogs and the guarded prognosis highlights the necessity to find new treatments. Masitinib mesylate is a highly selective tyrosine kinase inhibitor that predominantly targets c-Kit and PDGFR-α/β. This study evaluated the in-vitro activity of masitinib against three canine OSA cell lines after treatment with increasing concentrations of masitinib (0.1-50 µmol/l) at 24, 48, and 72 h. The IC50 values at 72 h for the three OSA cell lines (POS, HMPOS, and COS31) were determined to be 11.04, 7.09, and 9.74 µmol/l, respectively. In addition, increases in caspase-3/7 activity and transferase dUTP nick end labeling-positive cells indicated apoptotic cell death. Because increased levels of vascular endothelial growth factor are found in dogs with OSA, vascular endothelial growth factor in the supernatant was quantified. Overall, the study found that masitinib causes dose-time dependent OSA cell death in vitro through initiation of caspase-mediated apoptosis, which supports future OSA clinical trials.

Published
2013

64. Facilitating Healthy Coping in Patients with Diabetes: A Systematic Review

Author

Carolyn T. Thorpe, Joshua M. Thorpe, Lauren E. Fahey, Heather C. Johnson, Edwin B. Fisher, and Maithili Deshpande

Subjects
Family therapy, Male, Coping (psychology), Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Psychological intervention, MEDLINE, Health Promotion, Anxiety, Health Professions (miscellaneous), Article, Diabetes mellitus, Adaptation, Psychological, medicine, Humans, Problem Solving, Cognitive Behavioral Therapy, business.industry, Depression, Patient Acceptance of Health Care, medicine.disease, Cognitive behavioral therapy, Self Care, Health promotion, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Quality of Life, Female, medicine.symptom, business, Clinical psychology
Abstract

The purpose of this study is to summarize recent literature on approaches to supporting healthy coping in diabetes in 2 specific areas: (1) the impact of different approaches to diabetes treatment on healthy coping and (2) the effectiveness of interventions specifically designed to support healthy coping.A PubMed search identified 129 articles published August 1, 2006, to April 30, 2011, addressing diabetes in relation to emotion, quality of life, depression, adjustment, anxiety, coping, family therapy, behavior therapy, psychotherapy, problem solving, couples therapy, or marital therapy.Evidence suggests that treatment choice may significantly influence quality of life, with treatment intensification in response to poor metabolic control often improving quality of life. The recent literature provides support for a variety of healthy coping interventions in diverse populations, including diabetes self-management education, support groups, problem-solving approaches, and coping skills interventions for improving a range of outcomes; cognitive behavior therapy and collaborative care for treating depression; and family therapy for improving coping in youths.Healthy coping in diabetes has received substantial attention in the past 5 years. A variety of approaches show positive results. Research is needed to compare the effectiveness of different approaches in different populations and determine how to overcome barriers to intervention dissemination and implementation.

Published
2012

65. EU law qua global governance law? Deciphering regulatory and constitutional competence between EU environmental law and global governance

Author

S.E.M. Herlin Karnell, E Fahey, ACELG (FdR), Boundaries of Law, and EU Law

Subjects
050502 law, Competence (law), Environmental law, Public law, Political science, Law, 05 social sciences, 050602 political science & public administration, Global governance, 0505 law, 0506 political science
Abstract

This special issue looks at the normative implications of EU global regulatory efforts in the area of environmental policy. The EU Environmental Emissions Trading System (EU-ETS) represents an example of successful application of EU environmental standards where global standards harmonization had failed. The intersection between EU law and global law, however, seems increasingly porous and difficult to decipher. Post-Lisbon, the EU increasingly functions like a State in its actions with the world. Nonetheless, the operation of international law internally within the EU legal order has been the subject of many distinctive constitutional periods, both prior to and after the Treaty of Lisbon. In the recent judgment of the Grand Chamber of the Court of Justice on the EU-Emissions Trading System, the Court rejected claims that the application of the EU-ETS scheme to the aviation sector, specifically US airlines, was unlawful under EU and international law. In the realm of the environment, EU environmental protection is both a value and normative aspiration. Yet what is a successful legal outcome of the adoption of ambitious and aggressive global legal regulatory frameworks in this domain? How should contemporary EU global policy and value ambitions be adjudicated in law? The case raises broader issues about the legitimacy of EU law and externalities arising from extended EU competences to positively promote EU constitutional values beyond Europe. While using this case as its starting point, this special issue sets out to look at the wider constitutional questions asked by it.

Published
2012

66. Book Reviews/Recension

Author

Koreen E. Fahey, Gerald Bonham, Anne George, and Donna M Wilson

Subjects
medicine.medical_specialty, Public health, Public Health, Environmental and Occupational Health, medicine, General Medicine, Sociology, Religious studies, Article
Published
2006

67. Precision electroweak measurements on the Z resonance

Author

Schael, S Barate, R Bruneliere, R Buskulic, D De Bonis, I Decamp, D Ghez, P Goy, C Jezequel, S Lees, JP and Lucotte, A Martin, F Merle, E Minard, MN Nief, JY and Odier, P Pietrzyk, B Trocme, B Bravo, S Casado, MP and Chmeissani, M Comas, P Crespo, JM Fernandez, E and Fernandez-Bosman, M Garrido, L Grauges, E Juste, A and Martinez, M Merino, G Miquel, R Mir, LM Orteu, S and Pacheco, A Park, IC Perlas, J Riu, I Ruiz, H and Sanchez, F Colaleo, A Creanza, D De Filippis, N de Palma, M Iaselli, G Maggi, G Maggi, M Nuzzo, S and Ranieri, A Raso, G Ruggieri, F Selvaggi, G Silvestris, L and Tempesta, P Tricomi, A Zito, G Huang, X Lin, J and Ouyang, Q Wang, T Xie, Y Xu, R Xue, S Zhang, J and Zhang, L Zhao, W Abbaneo, D Bazarko, A Becker, U and Boix, G Bird, F Blucher, E Bonvicini, B Bright-Thomas, P and Barklow, T Buchmuller, O Cattaneo, M Cerutti, F and Ciulli, V Clerbaux, B Drevermann, H Forty, RW Frank, M and Greening, TC Hagelberg, R Halley, AW Gianotti, F and Girone, M Hansen, JB Harvey, J Jacobsen, R Hutchcroft, DE Janot, R Jost, B Knobloch, J Kado, M Lehraus, I and Lazeyras, P Maley, R Mato, P May, J Moutussi, A and Pepe-Altarelli, M Ranjard, F Rolandi, L Schlatter, D and Schmitt, B Schneider, O Tejessy, W Teubert, F Tomalin, IR Tournefier, E Veenhof, R Valassi, A Wiedenmann, W and Wright, AE Ajaltouni, Z Badaud, F Chazelle, G Deschamps, O Dessagne, S Falvard, A Ferdi, C Fayolle, D Gay, P and Guicheney, C Henrard, P Jousset, J Michel, B and Monteil, S Montret, JC Pallin, D Pascolo, JM Perret, P and Podlyski, F Bertelsen, H Fernley, T Hansen, JD and Hansen, JR Hansen, PH Kraan, AC Lindahl, A Mollerud, R and Nilsson, BS Rensch, B Waananen, A Daskalakis, G and Kyriakis, A Markou, C Simopoulou, E Siotis, I Vayaki, A and Zachariadou, K Blondel, A Bonneaud, G Brient, JC and Machefert, E Rouge, A Rumpf, M Swynghedauw, M Tanaka, R and Verderi, M Videau, H Ciulli, V Focardi, E Parrini, G and Zachariadou, K Corden, M Georgiopoulos, C Antonelli, A and Antonelli, M Bencivenni, G Bologna, G Bossi, F and Campana, P Capon, G Cerutti, F Chiarella, V Felici, G and Laurelli, P Mannocchi, G Murtas, GP Passalacqua, L and Picchi, P Colrain, P Ten Have, I Hughes, IS Kennedy, J and Knowles, IG Lynch, JG Morton, WT Negus, P O'Shea, V and Raine, C Reeves, P Scarr, JM Smith, K Thompson, AS and Turnbull, RM Wasserbaech, S Buchmuller, O Cavanaugh, R and Dhamotharan, S Geweniger, C Hanke, P Hansper, G and Hepp, V Kluge, EE Putzer, A Sommer, J Stenzel, H and Tittel, K Werner, W Wunsch, M Beuselinck, R Binnie, DM and Cameron, W Davies, G Dornan, PJ Goodsir, S and Marinelli, N Martin, EB Nash, J Nowell, J Rutherford, SA and Sedgbeer, JK Thompson, JC White, R Williams, MD and Ghete, VM Girtler, P Kneringer, E Kuhn, D Rudolph, G and Bouhova-Thacker, E Bowdery, CK Buck, PG Clarke, DP and Ellis, G Finch, AJ Foster, F Hughes, G Jones, RWL and Keemer, NR Pearson, MR Robertson, NA Sloan, T Smizanska, M Snow, SW Williams, MI van der Aa, O Delaere, C and Leibenguth, G Lemaitre, V Bauerdick, LAT Blumenschein, U and van Gemmeren, P Giehl, I Holldorfer, F Jakobs, K and Kasemann, M Kayser, F Kleinknecht, K Muller, AS Quast, G and Renk, B Rohne, E Sander, HG Schmeling, S Wachsmuth, H Wanke, R Zeitnitz, C Ziegler, T Aubert, JJ and Benchouk, C Bonissent, A Carr, J Coyle, P Curtil, C and Ealet, A Etienne, F Fouchez, D Motsch, F Payre, P and Rousseau, D Tilquin, A Talby, M Thulasides, M Aleppo, M and Antonelli, M Ragusa, F Buscher, V David, A Dietl, H and Ganis, G Huttmann, K Lutjens, G Mannert, C Manner, W and Moser, HG Settles, R Seywerd, H Stenzel, H Villegas, M Wiedenmann, W Wolf, G Azzurri, P Boucrot, J and Callot, O Chen, S Cordier, A Davier, M Duflot, L and Grivaz, JF Heusse, P Jacholkowska, A Le Diberder, F and Lefrancois, J Mutz, AM Schune, MH Serin, L Veillet, JJ and Videau, I Zerwas, D Azzurri, P Bagliesi, G and Bettarini, S Boccali, T Bozzi, C Calderini, G Dell'Orso, R Fantechi, R Ferrante, I Fidecaro, F Foa, L and Giammanco, A Giassi, A Gregorio, A Ligabue, F Lusiani, A and Marrocchesi, PS Messineo, A Palla, F Rizzo, G and Sanguinetti, G Sciaba, A Sguazzoni, G Spagnolo, P and Steinberger, J Tenchini, R Venturi, A Vannini, C and Venturi, A Verdini, PG Awunor, O Blair, GA Cowan, G and Garcia-Bellido, A Green, MG Medcalf, T Misiejuk, A and Strong, JA Teixeira-Dias, P Botterill, DR Clifft, RW and Edgecock, TR Edwards, M Haywood, SJ Norton, PR Tomalin, IR Ward, JJ Bloch-Devaux, B Boumediene, D Colas, P and Emery, S Fabbro, B Kozanecki, W Lancon, E Lemaire, MC and Locci, E Perez, P Rander, J Renardy, JF Roussarie, A and Schuller, JP Schwindling, J Tuchming, B Vallage, B and Black, SN Dann, JH Kim, HY Konstantinidis, N Litke, AM and McNeil, MA Taylor, G Booth, CN Cartwright, S and Combley, F Hodgson, PN Lehto, M Thompson, LF and Affholderbach, K Barberio, E Bohrer, A Brandt, S and Burkhardt, H Feigl, E Grupen, C Hess, J Lutters, G and Meinhard, H Minguet-Rodriguez, J Mirabito, L Misiejuk, A and Neugebauer, E Ngac, A Prange, G Rivera, F Saraiva, P and Schafer, U Sieler, U Smolik, L Stephan, F Trier, H and Apollonio, M Borean, C Bosisio, L Della Marina, R and Giannini, G Gobbo, B Musolino, G Pitis, L He, H Kim, H Putz, J Rothberg, J Armstrong, SR Bellantoni, L and Berkelman, K Cinabro, D Conway, JS Cranmer, K Elmer, P and Feng, Z Ferguson, DPS Gao, Y Gonzalez, S Grahl, J and Harton, JL Hayes, OJ Hu, H Jin, S Johnson, RP and Kile, J McNamara, PA Nielsen, J Orejudos, W Pan, Y and Saadi, Y Scott, IJ Sharma, V Walsh, AM Walsh, J and Wear, J von Wimmersperg-Toeller, JH Wiedenmann, W Wu, J and Wu, SL Wu, X Yamartino, JM Zobernig, G Dissertori, G and Abdallah, J Abreu, P Adam, W Adye, T Adzic, P and Ajinenko, I Albrecht, T Alderweireld, T Alekseev, GD and Alemany-Fernandez, R Allmendinger, T Allport, PP Almehed, S and Amaldi, U Amapane, N Amato, S Anashkin, E and Anassontzis, EG Andersson, P Andreazza, A Andringa, S and Anjos, N Antilous, P Apel, WD Arnoud, Y Ask, S and Asman, B Augustin, JE Augustinus, A Baillon, P and Ballestrero, A 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Kanzaki, J Karapetian, G and Karlen, D Kartvelishvili, V Kawagoe, K Kawamoto, T and Keeler, RK Kellogg, RG Kennedy, BW Kim, DH King, BJ and Kirk, J Klein, K Kleinwort, C Klem, DE Klier, A and Kluth, S Kobayashi, T Kobel, M Kopke, L Koetke, DS and Kokott, TP Komamiya, S Kormos, L Kowalewski, R Kramer, T and Kral, JF Kress, T Kreutzmann, H Krieger, P von Krogh, J Kroll, J Krop, D Kruger, K Kuhl, T Kupper, M Kuwano, M Kyberd, P Lafferty, GD Lafoux, H and Lahmann, R Lai, WP Lamarche, F Landsman, H Lanske, D and Larson, WJ Lauber, J Lautenschlager, SR Lawson, I and Layter, JG Lazic, D Le Du, P Leblanc, P Lee, AM and Lefebvre, E Lehto, MH Leins, A Lellouch, D Lennert, P and Leroy, C Lessard, L Letts, J Levegrun, S Levinson, L and Lewis, C Liebisch, R Lillich, J Littlewood, C Lloyd, AW Lloyd, SL Loebinger, FK Long, GD Lorah, JM and Lorazo, B Losty, MJ Lou, XC Lu, J Ludwig, A Ludwig, J Luig, A Macchiolo, A Macpherson, A Mader, W and Mattig, P Malik, A Mannelli, M Marcellini, S Marchant, TE Maringer, G Markus, C Martin, A Martin, JP and Martinez, G Masetti, G Mashimo, T Matthews, W Maur, U and McDonald, WJ McGowan, RF McKenna, J Mckigney, EA and McMahon, TJ McNab, AI McNutt, J McPherson, AC McPherson, RA Meijers, F Mendez-Lorenzo, P Menges, W Menke, S and Menszner, D Merritt, FS Mes, H Meyer, J Meyer, N and Michelini, A Middleton, RP Mihara, S Mikenberg, G and Mildenberger, J Miller, DJ Milstene, C Mir, R Moed, S and Mohr, W Moisan, C Montanari, A Mori, T Morii, M and Moss, MW Mouthuy, T Muller, U Murphy, PG Mutter, A and Nagai, K Nakamura, I Nanjo, H Neal, HA Nellen, B and Nguyen, HH Nijjhar, B Nisius, R Nozaki, M Oakham, FG and Odorici, F Ogg, M Ogren, HO Oh, A Oh, H Okpara, A and Oldershaw, NJ Omori, T O'Neale, SW O'Neill, BP Oram, CJ Oreglia, MJ Orito, S Pahl, C Palinkas, J and Palmonari, F Pansart, JP Panzer-Steindel, B Paschievici, P and Pasztor, G Pater, JR Patrick, GN Pawley, SJ and Paz-Jaoshvili, N Pearce, MJ Petzold, S Pfeifenschneider, P and Pfister, P Pilcher, JE Pinfold, J Pitman, D Plane, DE Poffenberger, P Poli, B Polok, J Pooth, O and Posthaus, A Pouladdej, A del Poz, LA Prebys, E and Pritchard, TW Przybycien, M Przysiezniak, H Quadt, A and Quast, G Rabbertz, K Raith, B Redmond, MW Rees, DL and Rembser, C Renkel, P Richards, GE Rick, H Rigby, D and Riles, K Robins, SA Robinson, D Rodning, N Rollnik, A and Roney, JM Rooke, A Ros, E Rosati, S Roscoe, K and Rossberg, S Rossi, AM Rosvick, M Routenburg, P Rozen, Y and Runge, K Runolfsson, O Ruppel, U Rust, DR Rylko, R and Sachs, K Saeki, T Sahr, O Sanghera, S Sarkisyan, EKG and Sasaki, M Sbarra, C Schaile, AD Schaile, O and Schappert, W Scharf, F Scharff-Hansen, P Schenk, P and Schieck, J Schmitt, B von der Schmitt, H Schmitt, S and Schorner-Sadenius, T Schreiber, S Schroder, M Schutz, P and Schultz-Coulon, HC Schulz, M Schumacher, M Schwarz, J and Schwick, C Schwiening, J Scott, WG Settles, M Seuster, R and Shears, TG Shen, BC Shepherd-Themistocleous, CH and Sherwood, P Shypit, R Simon, A Singh, P Siroli, GP and Sittler, A Skillman, A Skuja, A Smith, AM Smith, TJ and Snow, GA Sobie, R Soldner-Rembold, S Spagnolo, S Spano, F Springer, RW Sproston, M Stahl, A Starks, M and Steiert, M Stephens, K Steuerer, J Stier, HE and Stockhausen, B Stoll, K Strohmer, R Strom, D Strumia, F and Stumpf, L Surrow, B Szymanski, P Tafirout, R Takeda, H Takeshita, T Talbot, SD Tanaka, S Taras, P Tarem, S Tasevsky, M Taylor, RJ Tecchio, M Teixeira-Dias, P and Tesch, N Teuscher, R Thackray, NJ Thiergen, M Thomas, J and Thomson, MA von Torne, E Torrence, E Towers, S Toya, D Trocsanyi, Z Tran, P Transtromer, G Trefzger, T and Tresilian, NJ Trigger, I Tscheulin, M Tsukamoto, T Tsur, E Turcot, AS Tumer-Watson, MF Tysarczyk-Niemeyer, G and Ueda, I Ujvari, B Utzat, P Vachon, B Van den Plas, D and Van Kooten, R VanDalen, GJ Vannerem, P Vasseur, G and Vertesi, R Verzocchi, M Vikas, P Vincter, M Virtue, CJ and Vokurka, EH Vollmer, CF Voss, H Vossebeld, J and Wackerle, F Wagner, A Wagner, DL Wahl, C Walker, JP and Waller, D Ward, CP Ward, DR Ward, JJ Watkins, PM and Watson, AT Watson, NK Weber, M Weber, P Weisz, S and Wels, PS Wengler, T Wermes, N Wetterling, D Weymann, M and Whalley, MA White, JS Wilkens, B Wilson, JA Wilson, GW Wingerter, I Winterer, VH Wlodek, T Wolf, G Wood, NC Wotton, S Wyatt, TR Yaari, R Yamashita, S Yang, Y and Yeaman, A Yekutieli, G Yurko, M Zacek, V Zacharov, I and Zer-Zion, D Zeuner, W Zivkovic, L Zorn, GT Abe, K and Abe, K Abe, T Abt, I Acton, PD Adam, I Agnew, G and Akagi, T Akimoto, H Allen, NJ Ash, WW Aston, D and Bacchetta, N Baird, KG Baltay, C Band, HR Barakat, MB and Baranko, GJ Bardon, O Barklow, TL Bashindzhagian, GL and Battiston, R Bauer, JM Bazarko, AO Bean, A Bellodi, G and Ben-David, R Benvenuti, AC Berger, R Biasini, M and Bienz, T Bilei, GM Bisello, D Blaylock, G Bogart, J and Bolen, B Bolton, T Bower, GR Brau, JE Breidenbach, M and Bugg, WM Burke, D Burnett, TH Burrows, PN Busza, W and Calcaterra, A Caldwell, DO Camanzi, B Carpinelli, M and Carr, J Cassell, R Castaldi, R Castro, A Cavalli-Sforza, M Chadwick, GB Chou, A Church, E Claus, R Cohn, HO and Coller, JA Convery, MR Cook, V Cotton, R Cowan, RF and Coyle, PA Coyne, DG Crawford, G D'Oliveira, A and Damerell, CJS Daoudi, M Dasu, S de Groot, N de Sangro, R and De Simone, P De Simone, S Dell'Orso, R Dervan, PJ and Dima, M Dong, DN Doser, M Du, PYC Dubois, R Duboscq, JE Eigen, G Eisenstein, BI Elia, R Erdos, E and Erofeeva, I Eschenburg, V Etzion, E Fahey, S Falciai, D and Fan, C Fernandez, JP Fero, MJ Flood, K Frey, R and Friedman, JI Furuno, K Garwin, EL Gillman, T Gladding, G and Gonzalez, S Hallewell, GD Hart, EL Harton, JL Hasan, A Hasegawa, Y Hasuko, K Hedges, S Hertzbach, SS and Hildreth, MD Hitlin, DG Honma, A Huber, JS Huffer, ME and Hughes, EW Huynh, X Hwang, H Iwasaki, M Iwasaki, Y and Izen, JM Jackson, DJ Jacques, P Jaros, JA Jiang, ZY and Johnson, AS Johnson, JR Johnson, RA Junk, T and Kajikawa, R Kalelkar, M Kamyshkov, YA Kang, HJ Karliner, I Kawahara, H Kelsey, MH Kendall, HW Kim, YD King, M and King, R Kofler, R Krishna, NM Kwon, Y Labs, JF and Kroeger, RS Langston, M Lath, A Lauber, JA Leith, DWG and Lia, V Lin, C Liu, MX Loreti, M Lu, A Lynch, HL and Ma, J Mancinelli, G Manly, S Mantovani, G and Markiewicz, TW Maruyama, T Masuda, H Mazzucato, H and McGowan, JF McKemey, AK Meadows, BT Messner, R Mockett, PM Moffeit, KC Moore, TB Morii, M Mours, B Muller, D and Mueller, G Murzin, V Nagamine, T Narita, S and Nauenberg, U Neal, H Nesom, G Nussbaum, M Ohnishi, Y and Oishi, N Onoprienko, D Osborne, LS Panvini, RS Park, CH and Park, H Pavel, TJ Peruzzi, I Pescara, L Piccolo, M and Piemontese, L Pieroni, E Pitts, KT Plano, RJ and Prepost, R Prescott, CY Punkar, G Quigley, J Ratcliff, BN Reeves, K Reeves, TW Reidy, J Reinertsen, PL and Rensing, PE Rochester, LS Rothberg, JE Rowson, PC and Russell, JJ Saxton, OH Schalk, T Schindler, RH and Schneekloth, U Schumm, BA Schwiening, J Seiden, A Sen, S and Serbo, VV Servoli, L Shaevitz, MH Shank, JT Shapiro, G Sherden, DJ Shmakov, KD Simopoulos, C Sinev, NB and Smith, SR Smy, MB Snyder, JA Sokoloff, MD Staengle, H and Stahl, A Starner, P Steiner, H Steiner, R Strauss, MG Su, D Suekane, F Sugiyama, A Suzuki, A Suzuki, S and Swartz, M Szumilo, A Takahashi, T Taylor, FE Thaler, JJ Thom, J Torrence, E Trandafir, AI Turk, JD Usher, T Va'vra, J Vannini, C Vella, E Venuti, JP Verdier, R Verdini, PG Wagner, DL Wagner, SR Waite, AP and Walston, S Wang, J Watts, SJ Weidemann, AW Weiss, ER and Whitaker, JS White, SL Wickens, FJ Williams, DA and Williams, DC Williams, SH Willocq, S Wilson, RJ and Wisniewski, WJ Wittlin, JL Woods, M Word, GB Wright, TR and Wyss, J Yamamoto, RK Yamartino, JM Yang, XQ Yashima, J Yellin, SJ Young, CC Yuta, H Zapalac, G Zdarko, RW and Zeitlin, C Zhou, J ALEPH Collaborat DELPHI Collaborat and L3 Collaborat OPAL Collaborat SLD Collaborat

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment
Abstract

We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.

Published
2006

68. Maternally and paternally silenced imprinted genes differ in their intron content

Author

Tom Moore, Walter Mills, Desmond G. Higgins, Marie E. Fahey, and Apollo - University of Cambridge Repository

Subjects
Genetics, lcsh:QH426-470, Intron, Small sample, Biology, 3105 Genetics, lcsh:Genetics, lcsh:Biology (General), FOS: Biological sciences, Gene silencing, Control set, lcsh:Q, Generic health relevance, Allele, lcsh:Science, Genomic imprinting, lcsh:QH301-705.5, Molecular Biology, Gene, 31 Biological Sciences, Research Article, Biotechnology
Abstract

Imprinted genes exhibit silencing of one of the parental alleles during embryonic development. In a previous study imprinted genes were found to have reduced intron content relative to a non-imprinted control set (Hurstet al., 1996). However, due to the small sample size, it was not possible to analyse the source of this effect. Here, we re-investigate this observation using larger datasets of imprinted and control (non-imprinted) genes that allow us to consider mouse and human, and maternally and paternally silenced, imprinted genes separately. We find that, in the human and mouse, there is reduced intron content in the maternally silenced imprinted genes relative to a non-imprinted control set. Among imprinted genes, a strong bias is also observed in the distribution of intronless genes, which are found exclusively in the maternally silenced dataset. The paternally silenced dataset in the human is not different to the control set; however, the mouse paternally silenced dataset has more introns than the control group. A direct comparison of mouse maternally and paternally silenced imprinted gene datasets shows that they differ significantly with respect to a variety of intron-related parameters. We discuss a variety of possible explanations for our observations.

Published
2004

71. Electrical and optical properties of degenerately-doped

Author

B. C. Campbell, M. Freeman, PR Sharps, R. E. Fahey, RJ Dziendziel, J.L. Egley, J. M. Borrego, D.M. DePoy, ML Timmons, P. F. Baldasaro, G.W. Charache, and K. Zhang

Subjects
Interference filter, Electron mobility, Materials science, Effective mass (solid-state physics), Dopant, business.industry, Thermophotovoltaic, Band gap, Doping, Optoelectronics, Electron, business
Abstract

Degenerately-doped (>1019 cm−3) n-type InxGa1−xAs (x>0.53) possesses a number of intriguing electrical and optical properties relevant to electro-optic devices and thermophotovoltaic devices in particular. Due to the low electron effective mass of this material (mn*∼0.1) and the demonstrated ability to incorporate n-type dopants into the mid-1019 cm−3 range, both the Moss-Burnstein bandgap shift and plasma reflection characteristics are particularly dramatic. These properties are investigated for InxGa1−xAs as a function of doping concentration, dopant type, and growth conditions. For undoped InGaAs with a nominal bandgap of 0.6 eV, doping this material to 5×1019 cm−3 increased the effective optical bandgap to 1.1 eV and has a plasma turn-on wavelength of 5 microns. This filter was coupled to a non-absorbing interference filter, creating a functional tandem filter for thermophotovoltaic applications.

Published
1997
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72. Letter

Author

Koreen E Fahey and Nancy Edwards

Subjects
medicine.medical_specialty, business.industry, medicine, Physical therapy, Fundamentals and skills, business, Surgery
Published
2005
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73. GPS-Prot: A web-based visualization platform for integrating host-pathogen interaction data

Author

Alex Shapiro, Melanie J. Bennett, Sumit K. Chanda, Alan D. Frankel, Charles S. Craik, Dhiraj Kumar, Cathal Mahon, Marie E. Fahey, Kanury Rao, Lars Pache, Nevan J. Krogan, and Stefanie Jäger

Subjects
Computer science, Systems biology, Host–pathogen interaction, education, HIV Infections, lcsh:Computer applications to medicine. Medical informatics, Biochemistry, World Wide Web, 03 medical and health sciences, User-Computer Interface, 0302 clinical medicine, Software, Structural Biology, Human–computer interaction, Protein Interaction Mapping, Humans, natural sciences, lcsh:QH301-705.5, Human proteins, Molecular Biology, 030304 developmental biology, Web based visualization, 0303 health sciences, Internet, business.industry, Applied Mathematics, Systems Biology, Computer Science Applications, ComputingMethodologies_PATTERNRECOGNITION, lcsh:Biology (General), Host-Pathogen Interactions, Global Positioning System, HIV-1, lcsh:R858-859.7, The Internet, business, 030217 neurology & neurosurgery
Abstract

BackgroundThe increasing availability of HIV-host interaction datasets, including both physical and genetic interactions, has created a need for software tools to integrate and visualize the data. Because these host-pathogen interactions are extensive and interactions between human proteins are found within many different databases, it is difficult to generate integrated HIV-human interaction networks.ResultsWe have developed a web-based platform, termed GPS-Prothttp://www.gpsprot.org, that allows for facile integration of different HIV interaction data types as well as inclusion of interactions between human proteins derived from publicly-available databases, including MINT, BioGRID and HPRD. The software has the ability to group proteins into functional modules or protein complexes, generating more intuitive network representations and also allows for the uploading of user-generated data.ConclusionsGPS-Prot is a software tool that allows users to easily create comprehensive and integrated HIV-host networks. A major advantage of this platform compared to other visualization tools is its web-based format, which requires no software installation or data downloads. GPS-Prot allows novice users to quickly generate networks that combine both genetic and protein-protein interactions between HIV and its human host into a single representation. Ultimately, the platform is extendable to other host-pathogen systems.

Published
2011
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79. Book Reviews

Author

William E. Fahey

Subjects
Pediatrics, Perinatology and Child Health, Developmental and Educational Psychology
Published
1996
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83. A new family of ester lubricants for PVC

Author

J. A. Falter, T. E. Fahey, and M. Rosen

Subjects
Marketing, chemistry.chemical_classification, Materials science, Polymers and Plastics, General Chemical Engineering, Carboxylic acid, General Engineering, General Chemistry, Gloss (optics), Lubricity, Polyol, chemistry, Hydroxyl value, Materials Chemistry, Lubrication, Organic chemistry, Thermal stability, Extrusion
Abstract

A new class of complex esters offers the capability for tailoring lubrication characteristics to specific PVC applications. The lubricating performance of these esters can be varied from internal to external through changes in carboxylic chain length, polyol moiety, and degree of esterification. Changes in the degree of functionality of the polyol portion of the ester can be used to affect large variations in fusion time and mill stick time. Polyol functionality may also be used to control extrudate gloss without changes in other processing parameters. Dynamic stability is relatively independent of polyol type, with all of the esters providing excellent stability behavior. Carboxylic acid chain length has a pronounced effect on external lubricity, as demonstrated by large changes in mill stick time. Esters based on stearic or longer chain acids provide optimum extrusion processability and yield high gloss extrudates at low extrusion torques. Dynamic thermal stability also increases with acid chain length. The effect of degree of esterifications on lubrication is dependent upon the polyol portion of the ester. In low hydroxyl value esters, the degree of esterification can be used to vary external lubricity.

Published
1988
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84. Applications of compaction testing to the processability of rigid PVC compounds

Author

Timothy E. Fahey

Subjects
Fusion, Materials science, Polymers and Plastics, Shear (geology), Materials Chemistry, Compaction, Lubrication, Grain boundary, General Chemistry, Composite material, Proctor compaction test, Elasticity (economics), Condensed Matter Physics
Abstract

A compaction test has been developed to examine the lubrication and fusion characteristics of PVC compounds. A model of the compaction process at low pressures is proposed which involves two distinct modes of compaction. Initial densification quickly reaches a plateau density, the magnitude of which is determined primarily by frictional properties and the elastic deformability. of the resin particles. A second slower rate densification is attributed to fusion within the PVC resin grains, as well as diffusion between grains. It is shown that compaction alone is insufficient for grain boundary destruction. As a result, significantly higher temperatures are needed to achieve a given state of elasticity development by compaction when compared to material produced by shear processing.

Published
1981
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86. Residual infrared absorption in as-grown and annealed crystals of Ti:Al/sub 2/O/sub 3

Author

A.J. Strauss, W.R. Rapoport, R. E. Fahey, C.P. Khattak, Antonio Sanchez, R. L. Aggarwal, and M. M. Stuppi

Subjects
Crystal, Zone melting, Materials science, Absorption spectroscopy, Annealing (metallurgy), Reducing atmosphere, Analytical chemistry, Infrared spectroscopy, Crystal growth, Electrical and Electronic Engineering, Condensed Matter Physics, Spectroscopy, Atomic and Molecular Physics, and Optics
Abstract

Data for as-grown and partially oxidized samples of Ti:Al/sub 2/O/sub 3/ grown by the vertical-gradient-freeze technique show that the residual infrared absorption in these samples is largely due to Ti/sup 3+/-Ti/sup 4+/ pairs. In agreement with this pair model, the residual absorption in as-grown samples has been substantially decreased by annealing in a reducing atmosphere. Data for an as-grown crystal grown by the heat exchanger method indicate the presence of a second mechanism for residual absorption that may set a lower limit on the ratio of this absorption to the Ti/sup +3/ absorption used to pump laser emission. >

Published
1988
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87. Small-signal gain measurement in a Ti:Al/sub 2/O/sub 3/ amplifier

Author

A.J. Strauss, R. E. Fahey, R. L. Aggarwal, and K. F. Wall

Subjects
Power gain, Amplified spontaneous emission, Materials science, business.industry, Amplifier, Analytical chemistry, Superradiance, Laser pumping, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, Optical pumping, Solid-state laser, Optoelectronics, Electrical and Electronic Engineering, business, Lasing threshold
Abstract

A small-signal single-pass power gain of e/sup 5.2/=180 has been measured for a signal in the pi polarization at 790.7 nm in a longitudinally pumped Ti:Al/sub 2/O/sub 3/ amplifier. A double-pass power gain of e/sup 5.2/ approximately=10/sup 4/ has been attained for the same polarization at 799.8 nm. The ratio of the gain cross sections at 632.8 and 790.7 nm is 1/25. The gain anisotropy at 632.8 nm is g/sub pi //g/sub sigma /=2.3. The lifetime of the upper lasing level decreases with increased pumping, probably as the result of amplified spontaneous emission. >

Published
1988
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88. False suspicion and the misperception of deceit

Author

William E. Fahey and Charles F. Bond

Subjects
Social Psychology, Social perception, media_common.quotation_subject, Perceptual Distortion, Deception, Psychology, Social psychology, Lying, False accusation, media_common
Abstract

Truth tellers may look dishonest when suspected of lying; if so, perceivers should be vulnerable to mistakes in recognizing the truth. In an experiment we find evidence of this error in truth detection. The error reflects a seeming confirmation of false accusations and is not merely a perceptual distortion. Affective and motivational explanations for the error are considered.

Published
1987
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90. Morphological progression and elasticity development in the single-screw extrusion of rigid PVC

Author

Timothy E. Fahey

Subjects
Fusion, Materials science, Hydrostatic test, Polymers and Plastics, Capillary rheometer, Materials Chemistry, Extrusion, General Chemistry, Elasticity (economics), Composite material, Condensed Matter Physics, Melt pool
Abstract

The morphological progression of rigid PVC compounds during single-screw extrusion is examined in relation to the melting mechanism and elasticity development. It is shown that no grain destruction occurs in the solid bed. 100-μm domains persist in the solid bed after extensive intergrain fusion has occurred. The melt pool is composed of clusters of primary particles in the early screw flights, but shows no evidence of particulate structure of this size in later flights. A capillary rheometer entrance pressure test is used to demonstrate the development of elasticity in both the solid bed and melt pool. Development of elastic response progresses at a higher rate in the solid bed of mass resin-based compounds. Elasticity of the melt pool is high at all stages of extrusion, but also shows a progression.

Published
1981
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91. Crystal growth, spectroscopy, and laser characteristics of Ti:Al/sub 2/O/sub 3

Author

R. E. Fahey, R. L. Aggarwal, A.J. Strauss, and Antonio Sanchez

Subjects
Zone melting, Materials science, Absorption spectroscopy, Analytical chemistry, Infrared spectroscopy, Crystal growth, Condensed Matter Physics, Laser, Atomic and Molecular Physics, and Optics, law.invention, law, Sapphire, Electrical and Electronic Engineering, Laser-induced fluorescence, Spectroscopy
Abstract

The vertical-gradient-freeze technique has been used to grow laser-quality Ti:Al/sub 2/O/sub 3/ single crystals. Ti/sup 3+/-Ti/sup 4+/ pairs have been shown to be responsible for the residual infrared absorption. Room-temperature oscillator and amplifier experiments are reviewed. >

Published
1988
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95. Reports of Standing Committees for 1967

Author

Robert Glen, F. W. Fletcher, C. N. Smith, Robert E. Hamman, Y. P. Sun, W. S. Craig, G. W. Schaeffer, W. L. Popham, H. H. Ross, Richard H. Foote, T. L. Bissell, D. A. Lindquist, Floyd P. Harrison, George L. Hutton, H. L. Gunderson, J. W. Gentry, E. G. Munroe, H. S. Telford, R. B. Thrailkill, S. C. Billing, O. H. Graham, M. M. Furniss, Gordon Guyer, R. E. Hamman, C. C. Blickenstaff, Martin Sherman, C Alejandro Ortega, E. A. Steinhaus, R. C. Back, L. K. Cutkomp, W. E. Allison, W. P. Boyer, John A. Lofgren, E. H. Wheeler, J. M. Kingsolver, D. F. Bray, Clay Lyle, J. G. Rodrigues, A.W. Lindquist, F. S. Arant, H. M. Armitage, J. E. Swift, W. N. Stoner, H. W. Goble, K. G. Swenson, H. L. Bruer, L. G. Davis, John V. Osmun, A. M. Boyce, R. M. DeCoursey, Jack E. Fahey, H. D. Pratt, Henry E. Gray, James R. Brazzel, J. M. Geary, E. J. Gerberg, Ralph W. Sherman, J. S. Yuill, L. O. Warren, and H. G. Wressell

Subjects
General Medicine
Published
1968
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96. Persistence and Distribution of Gardona and Dichlorvos in Grain and Grain Products12

Author

R. C. Hall, J. E. Fahey, D. L. Ballee, and Gary W. Bennett

Subjects
Wheat grain, Ecology, Bran, digestive, oral, and skin physiology, food and beverages, General Medicine, Biology, Phosphate, chemistry.chemical_compound, Residue (chemistry), chemistry, Agronomy, Insect Science, Dichlorvos, Germ, Food science
Abstract

Gardona® (2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate) was persistent on corn and wheat grain held in farm storage for 8 months. Dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was rapidly lost from both grains, but it did exhibit some tendency to persist at trace residue levels. The corn milling products, bran, fine feed, and germ, contained 94% of the total Gardona residue and the only detectable dichlorvos residue. The wheat bran contained 67% of the dichlorvos residue and 90% of the Gardona residue.

Published
1973
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97. An Outbreak of Staphylococcal Arthritis in Turkey Poults

Author

J. E. Fahey

Subjects
Veterinary medicine, business.industry, medicine.drug_class, Antibiotics, Outbreak, General Medicine, Anorexia, Disease, medicine.disease_cause, Virology, Lameness, Staphylococcus aureus, Medicine, Animal Science and Zoology, Flock, medicine.symptom, business, Emaciation
Abstract

INTRODUCTION STAPHYLOCOCCAL arthritis has been recognized for many years as a disease entity occurring in all domestic fowl. This condition is due to Micrococcus pyogenes var aureus (Staphylococcus aureus) and occurs in a chronic or acute form (Lucet, 1892; Hole and Purchase, 1931). The disease symptoms are generally lameness, hobbling gait, swollen joints, anorexia and ultimately emaciation (Hole and Purchase, 1931; Jungherr, 1933; Gwatkin, 1940). Attempts to treat the disease with drugs or with autogenous bacterins have been unsuccessful or inconclusive (Jungherr and Plastridge, 1941; Madsen, 1942; Hinshaw and McNeil, 1952). In this study are presented the details of an outbreak of staphylococcal arthritis in turkey poults, which was successfully treated with antibiotics. HISTORY OF OUTBREAK In June 1953, 408 Broad Breasted Bronze (B.B.B.) turkey poults were started and were to serve as part of the next year’s breeder flock. These birds were apportioned into two pens of approximately 200 …

Published
1954
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