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Malaria is responsible for nearly one million deaths annually, and the increasing prevalence of multi-resistant strains of Plasmodium falciparum poses a great challenge to controlling the disease. A diverse set of flavones, isosteric to 4(1H)-quinolones, were prepared and profiled for their antiplasmodial activity against the blood stage of P. falciparum W2 strain, and the liver stage of the rodent parasite Plasmodium berghei. Ligand efficient leads were identified as dual stage antimalarials, suggesting that scaffold optimization may afford potent antiplasmodial compounds., (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)

Release of domestic sewage leads to accumulation of xenoestrogens in holding waters, especially in closed or semi-enclosed waters such as lakes. In the study, the occurrence, distribution, estrogenic activity and risk of eight xenoestreogens were evaluated in Lake Donghu, China. Nonylphenol (NP), octylphenol (OP), and bisphenol A (BPA) were identified as the main xenoestrogens ranging from tens of ngL(-1) (in the surface water) or ng g(-1)dw (in the suspended particles and sediment) to tens of μgL(-1) or μg g(-1)dw. The sum of 17β-estradiol equivalents (∑EEQs) ranged from 0.32 to 45.02 ngL(-1) in the surface water, 0.53 to 71.86 ng g(-1)dw in the suspended particles, and 0.09 to 24.73 ng g(-1)dw in the sediment. Diethylstilbestrol (DES) was determined as the main contributor to ∑EEQs followed by NP. The risk assessment showed a higher risk in the surface water than in the suspended particles and sediment in such domestic sewage-holding lake., (Copyright © 2013 Elsevier Ltd. All rights reserved.)