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The acetone extract of the roots of Salvia jaminiana, containing the sterols campestanol, stigmasterol and sitosterol, and five known diterpenoids, ferruginol, cryptanol, 6,7-dehydroroyleanon, 6-hydroxysalvinolone and microstegiol, remarkably inhibited the growth of Bacillus subtilis, Staphylococcus aureus ATCC 25923 and Streptococcus alpha-hemolitic.

Hyperfoliatin, a new polyisoprenylated phloroglucinol derivative was isolated from the aerial parts of Hypericum perfoliatum (Clusiaceae) collected in Algeria. The structure of hyperfoliatin was elucidated on the basis of its spectral data, mainly MS and multiple-pulse NMR.

The methanol extract of the dried stem bark of Drypetes armoracia PaxHoffm. afforded two compounds named drypearmoracein A, (E)-4,5,6,7-tetrahydroxy-2-benzylhept-2-enoic acid and drypearmoracein B, 2,3-dihydroxy-9,10-tetrahydroanthra-1,4-quinone along with five known compounds: friedelan-3 beta-ol, friedelin, friedelane-3,7-dione, drypemolundein B and beta-stigmasterol. Their structures were established on the basis of spectroscopic analysis and chemical evidence.

The novel 6-dialkylaminoalkylamino-3,3,12-trimethyl-3,12-dihydro-7H-pyrano[2,3-c]acridine-7-ones 5-11 and their benzo [b]pyrano[2,3-h]acridine-7-one counterparts 12-18 were prepared by treatment of acronycine (1) or benzo[b]acronycine (4) with an excess of the appropriate dialkylaminoalkylamine. In both series, the introduction of a dialkylaminoalkylamino side chain at position 6 resulted in a significant increase of the cytotoxic activity against L1210 cells when compared with the parent compounds bearing a methoxy group, accompanied with an increased potency to arrest cells in the G2 + M phases of the cell cycle.

Eleven phenolic Compounds have been isolated from the ethanolic extract of SELAGINELLA DOEDERLEINII by a combination of Chromatographic techniques. These are five lignans: (-)-lirioresinol A, (-)-lirioresinol B, (+)-wikstromol, (-)-nortracheloside, (+)-matairesinol ( 1), two phenylpropanones: 3-hydroxy-1-(3-methoxy-4-hydroxyphenyl)-propan-1-one ( 2), 3-hydroxy-1-(3,5 -dimethoxy-4-hydroxyphenyl)-propan-1-one ( 3), and four biflavonoids: amentoflavone, 7,7''-di- O-methylamentoflavone, 7,4',7'',4'''-tetra- O-methylamentoflavone, and heveaflavone ( 4). Compounds 1, 2, and 3 are novel natural secondary metabolites. Their structures were deduced from their spectral data (mainly (1)H-NMR, mass, and CD). Lignans are described here for the first time in the family Selaginellaceae. Their cytotoxic activity against L 929 murine cells accounts for the use of the plant in traditional Chinese medicine as an anticancer agent.

Oduocine, a novel noraporphine and oxoduocine, a novel oxaporphine, have been isolated from the roots of Lindera myrrha . Their structures have been deduced from their spectral data.

Three new natural dithiopyrrolone antibiotics, 3-methyl-2-butenoylpyrrothine (1), tigloylpyrrothine (2), and n-butyropyrrothine (3) were isolated along with the known iso-butyropyrrothine (4) and thiolutin (5) from the fermentation broth of Saccharothrix sp. SA 233. The structures of the novel compounds were established on the basis on their spectral data.

Three new natural antibacterial and antifungal dithiolopyrrolone antibiotics were isolated along with the known iso-butyropyrrothine and thiolutine from the fermentation broth of an actinomycete strain which was isolated from a saharian palm grove soil collected at Adrar, south Algeria. The strain was identified as Saccharothrix sp. The three new antibiotics exhibited broad antimicrobial activity against Gram-positive bacteria, yeasts and fungi in vitro.

Acronycine is active against a broad spectrum of solid tumors. Structure activity relationships demonstrated the crucial role of the 1,2-double bond. A hypothesis of bioactivation into 1,2-epoxide led to the development of a series of 1,2-dihydroxy-1,2-dihydroacronycine and 1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine diesters that exhibited an increased potency when compared with the parent compound.

1) Departement de Chimie, Faculte de Sciences, Universite Mentouri Constantine, Route d’Ain el Bey, 25000Constantine, Algerie, fax: 213 31 81 88 85, e-mail: salah4dz@yahoo.fr; 2) Departement de Biologie, Faculte de Sciences,Universite Ferhat Abbas, 19000 Setif, Algerie; 3) Laboratoire de Pharmacognosie, Universite de Rouen-Haute Normandie,UMR6014-CNRS, Faculte de Pharmacie, 22 Boulevard Gambetta, F-76183 Rouen Cedex, France; 4) Laboratoire de ChimieAnalytique, ADEN EA 3234, Universite de Rouen-Haute Normandie, Faculte de Pharmacie, 22 Boulevard Gambetta, F-76183Rouen Cedex 1, France. Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 411-412, July-August, 2008. Original articlesubmitted January 29, 2007. 510 0009-3130/08/4404-0510

Mentouri–Constantine, Campus Chaabet Ersas, 25000 Constantine, Algerie, fax: (21331) 63 53 52, e-mail: zkabouche@hotmail.com; 2) Equipe Pharmacomodulation d′antitumoraux d′origine naturelle et synthetique, Laboratoire de Pharmacognosie, Faculte de Pharmacie, 22, Boulevard Gambetta, F-76183 Rouen Cedex 1, France; 3) Laboratoire de Pharmacognosie de l′Universite Rene Descartes, U.M.R./C.N.R.S. N 8638, Faculte des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l′Observatoire, F-75006 Paris, France; 4) Universite de Rennes 1, U.M.R./C.N.R.S. N 6509, Campus de Beaulieu, 35042 Rennes cedex, France. Pablished in Khimiya Prirodnykh Soedinenii, No. 2, pp. 159-160, March-April, 2004. Original article submitted January, 12, 2004

The essential oil of aerial parts of Cachrys libanotis L. (Apiaceae) from east Algeria was extracted by hydrodistillation and analyzed by GC-FID and GC-MS. Thirty-one compounds were identified, the main components being germacrene-D (18.0%), γ-terpinene (6.4%), p-cymene (5.5%), caryophyllene oxide (5.1%), and limonene (5.1%).

Partial Synthesis and Oncostatic Properties of Pseudotubulosines, Analogues of Emetine and Tubulosine Pseudotubulosines, structural analogues of emetine and tubulosine, have been synthesized by either Pictet-Spengler or Bischler-Napieralski condensation from dihydrocorynantheal or corynantheidal. Spectral data, cytotoxic and oncostatic properties of these new alkaloids are described.

Racemic 7-hydroxy-9-oxa anthracyclinone (5a) has been synthetised in seven steps from quinizarin (6) and its resolution achieved after glycosylation with 3, 4-di-O-acetyl-2-deoxy-L-fucose. Chiral pool syntheses of (8S)-8-hydroxymethyl-9-oxa-anthracyclinone (5b) and of (8S, 10R) and (8S, 10S)-8-hydroxymethyl-10-methyl-9-oxa-anthracyclinones (5c and 5d) have been achieved using (R)-2, 3-O-isopropylideneglyceraldehyde (12) and leucoquinizarin (13) as starting materials. Glycosylation of aglycones 5b-5d by either 3, 4-di-O-acetyl-2-deoxy-L-fucose or various 3-amino-2, 3, 6-trideoxy-L-hexoses yielded the corresponding anthracyclines. The synthetic glycosides do not show significant cytotoxic activity at a concentration of 1 μg/ml against L 1210 cells.

Three new alkaloids have been isolated from the leaves of Ochrosia alyxioides: 10-methoxycorynanthreol, 10-methoxyantirhine, and 10-hydroxyantirhine. Their structures have been established on the basis of their spectral data and chemical properties. In addition, seven known alkaloids have been isolated from the leaves and nine from the stem bach, which has also yielded 10-methoxyantirhine

Syntheses a partir des (I)- et (+)-6-ethoxy-3-ethyl-2,3,4,5-tetrahydro pyridine-4-acetates d'ethyle et de 3-chloroacetyl-6-methoxyindole