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This essay explores two types of population policies common in Arab countries: pro‐natalist policies, aimed at encouraging higher birth rates, and anti‐natalist policies, aimed at reducing birth rates. Determining their practical impact is often challenging due to the lack of control or comparison groups. However, historical policy patterns in two groups of Arab countries over the past six decades offer a unique opportunity for comparison. Between the 1970s and 1990s these two groups implemented opposing programs (pro‐ vs. anti‐natalist), followed by predominantly anti‐natalist policies in both groups. By comparing fertility rates between these groups and discussing various factors influencing fertility changes, this study suggests that the influence of population policies in Arab countries may have been smaller than anticipated, to the point that it is questionable whether they have been worthwhile. [ABSTRACT FROM AUTHOR]

Recently, there has been worldwide growing interest on profiling the human fertility of populations because there has been a noticeable global decline in fertility rate, leading to increased attention toward reproductive health and fertility. The decline in fertility of population of the Arab World was investigated for the 10 years period between 2011–2021. The Arab World was classified into three regional blocks; Block-1 Arabian Peninsula countries: Bahrain, Kuwait, Saudi Arabia, Oman, Qatar, United Arab Emirates (UAE), Yemen. Block-2 Fertile Crescent Arab countries: Iraq, Jordan, Lebanon, Syria, West Bank and Gaza. Block-3 African Arab countries: Algeria, Comoros, Djibouti, Egypt, Libya, Mauritania, Morocco, Somalia, Sudan, Tunisia. Data on fertility rates for the 10 years period between 2011–2021 were collected from the World Bank for Arab countries. Statistical analysis along with decline in the fertility rates were determined. Results: Fertility rates varied across Arab countries in 2011 and 2021, with notable decline ranging from 24.3% to 3.8%, except for Algeria, with zero decline. Countries that exhibited significant decline were Jordan (24.3%) followed by Iraq (22.2%) then Yemen (19.1%); Whereas, countries that exhibited slight fertility decline were Libya (3.8%), followed by Tunisia (4.5%), Lebanon (4.5%) and Kuwait (4.5%). On another note, lowest fertility rate was observed in UAE as maintained between 1.7% and 1.5% and the highest fertility rate was observed in Somalia as maintained between 7.3% and 6.3% for 2011 and 2021 respectively. Conclusion: The present study reveals the declining-trend in fertility rate across Arab countries, influenced by variable factors. Therefore, we recommend to the Council of the Health Ministries in the Arab-League to focus on investigating the fertility decline as an important parameter for public health in the Arab world to maintain natural balanced fertility rate. As some non-biological factors surrounding the Arabian region, such as instability, war, migration, the present study did not aim to include the influence of war and migration on fertility because both war and migration are non-biological external factors and both are not among the WHO criteria for fertility determination which based of the population growth rate of population under normal living conditions. [ABSTRACT FROM AUTHOR]

The Charnov‐Bull hypothesis is the leading explanation for the evolution of environmental sex determination (ESD), which includes temperature‐dependent sex determination (TSD), the most common form of ESD. Charnov‐Bull predicts a sex‐by‐incubation temperature interaction for fitness, matching offspring sex with thermal conditions that increase parental fitness. However, there is no general explanation for how the sex‐by‐temperature interaction arises. Two competing explanations for the interaction lie in the survival to maturity hypothesis (SM) and the Trivers–Willard extension (TW). Under SM, the sex that matures later is produced under optimal incubation regimes as the late‐maturing sex accrues more mortality by maturation, while TW suggests that males are always produced under optimal incubation regimes as male mating success is more sensitive to condition (general health, vigor) than female fecundity. In a system where females mature later than males, as in the painted turtle Chrysemys picta, SM and TW generate opposite predictions for the effect of incubation temperature on juvenile survival. We incubated C. picta eggs under either female‐promoting temperatures (28 ± 3 °C) or male‐promoting temperatures (25 ± 3 °C), then released the hatchlings into their natal pond. We used a Bayesian capture–mark–recapture approach to follow their survival over two growing seasons. We found a 2% depression of biweekly survival in individuals incubated under the cooler temperature, providing subtle support for SM. Incubation treatments did not influence growth. Large‐scale field experiments such as this one will be necessary for understanding TSD evolution, and we underline general principles to execute such experiments successfully. [ABSTRACT FROM AUTHOR]

Previous studies have shown cord-blood DNA methylation differences in newborns conceived using assisted reproductive technologies (ART) compared to those conceived naturally. However, whether these ART-related DNA methylation differences vary with children's sex is unknown. We hypothesize that the DNA methylation differences in cord blood between ART-conceived and naturally conceived newborns also varies by the sex of the child, with distinct patterns of differential methylation present in males and females. We investigated sex differences in cord-blood DNA methylation variation according to conception by ART using the Illumina MethylationEPIC platform, comparing 456 ART-conceived versus 507 naturally-conceived girls, and 503 ART-conceived and 473 naturally-conceived boys. We identified 37 differentially methylated CpGs according to ART-conception among girls, and 70 differentially methylated CpGs according to ART-conception among boys, when we used a 1% false discovery rate to account for multiple testing. Ten CpGs were differentially methylated according to conception by ART in both sexes. Among the genes that were associated with these CpGs, we found the BRCA1; NBR2 gene (two CpGs) was hypermethylated in girls while the APC2 (two CpGs) and NECAB3;ACTL10, (four CpGs) related to cellular signaling were hypomethylated in boys. These findings confirm the presence of sex-specific epigenetic differences, illustrating the nuanced impact of ART on the fetal epigenome. There is a need for further explorations into the implications for sex-specific developmental trajectories and health outcomes in ART-conceived children. [ABSTRACT FROM AUTHOR]

In mammals, the transition from mitosis to meiosis facilitates the successful production of gametes. However, the regulatory mechanisms that control meiotic initiation remain unclear, particularly in the context of complex histone modifications. Herein, we show that KDM2A, acting as a lysine demethylase targeting H3K36me3 in male germ cells, plays an essential role in modulating meiotic entry and progression. Conditional deletion of Kdm2a in mouse pre-meiotic germ cells results in complete male sterility, with spermatogenesis ultimately arrested at the zygotene stage of meiosis. KDM2A deficiency disrupts H3K36me2/3 deposition in c-KIT+ germ cells, characterized by a reduction in H3K36me2 but a dramatic increase in H3K36me3. Furthermore, KDM2A recruits the transcription factor E2F1 and its co-factor HCFC1 to the promoters of key genes required for meiosis entry and progression, such as Stra8, Meiosin, Spo11, and Sycp1. Collectively, our study unveils an essential role for KDM2A in mediating H3K36me2/3 deposition and controlling the programmed gene expression necessary for the transition from mitosis to meiosis during spermatogenesis. Synopsis: The role of histone demethylation in spermatogenesis remains incompletely understood. This work shows that KDM2A demethylates trimethylated histone H3 lysine 36 (H3K36me3) and cooperates with the transcription factor E2F1 and its co-factor HCFC1 during the transition from mitosis to meiosis. KDM2A is essential for meiotic initiation and progression by promoting meiotic gene expression and suppressing the expression of genes involved in spermatogonial development. In male germ cells, KDM2A specifically demethylates H3K36me3, thus increasing H3K36me2 levels. KDM2A interacts with E2F1 and HCFC1 to facilitate meiotic gene expression and ensure proper meiotic progression. The balance of H3K36 di- and tri-methylation regulates meiotic gene expression during mouse spermatogenesis. [ABSTRACT FROM AUTHOR]

Aims: The aim of this study is to introduce the Copenhagen Multi‐Centre Psychosocial Infertility (COMPI)‐Fertility Problem Stress Scales (COMPI‐FPSS) into China and test its applicability in Chinese infertile population. Background: Infertility‐related stress not only influences patients' psychological well‐being but is also strongly associated with reduced pregnancy rates and poorer assisted conception outcomes, thus warranting focussed attention. Design: The design used in this study is a cross‐sectional survey. Methods: A total of 418 participants were recruited by convenience sampling from March to July 2022. The data were randomly divided into two parts: one for item analysis and exploratory factor analysis and the other for confirmatory factor analysis and reliability test. The critical ratio and homogeneity test were used to verify the differentiation and homogeneity of the COMPI‐FPSS; the construct validity was determined by explanatory and confirmatory factor analyses; Cronbach's α coefficient and Spearman–Brown coefficient were used to assess the reliability; and criterion validity was expressed using correlation coefficients for the Perceived Stress Scale and the Negative Affect Scale as the validity criteria. Results: The revised Chinese version of COMPI‐FPSS has 11 items and 2 dimensions (i.e., personal stress domain and social stress domain). Exploratory factor analysis showed that the cumulative variance contribution rate of the two factors was 68.6%, and confirmatory factor analysis indicated that the model fitted well. The score of the COMPI‐FPSS was significantly and positively associated with perceived stress and negative affect. The Cronbach's α coefficient of the total scale was 0.905, and the Spearman–Brown coefficient was 0.836, explaining excellent reliability. Conclusion: The revised Chinese version of COMPI‐FPSS shows good reliability and validity, and it can be used to evaluate the infertility‐related stress of infertile patients in China. Summary statement: What is already known about this topic? With the number of infertile people on the rise globally, infertility‐related stress needs attention.Copenhagen Multi‐Centre Psychosocial Infertility (COMPI)‐Fertility Problem Stress Scales (COMPI‐FPSS) with its brief and accessible entries is extensively applied abroad.China currently lacks such a tool. What this paper adds? This study translated the COMPI‐FPSS into Chinese and the Chinese version of COMPI‐FPSS contains 11 items and 2 dimensions, including personal stress domain and social stress domain, which has good reliability and validity. The implications of this paper: The Chinese version of COMPI‐FPSS could provide a short and reliable tool for clinical practice and research, which will reduce the burden on researchers and patients. [ABSTRACT FROM AUTHOR]

Human development and family planning programs since the 1970s have led to a fast‐rising prevalence of modern contraceptive means at the global level. However, countries with rising but still low levels of contraceptive use experienced an increasing number of societal upheavals, including armed conflicts, sudden and high‐intensity natural disasters, as well as dramatic effects of health epidemics. This may challenge the continued diffusion of modern means of birth regulation as well as their adherent use. To better understand the role of societal upheavals in the contraceptive transition, we provide a narrative literature review of their multidimensional pathways of influence in the contraceptive decision‐making process. The review suggests four main findings. First, well‐known contemporary barriers to contraceptive use become more salient during societal upheavals. Second, historical barriers reemerge predominantly. Third, societal upheavals exert specific effects on the contraceptive transition, such as through birth replacement, the repopulation of communities, and the sexual vulnerability of girls and young women. Fourth, there are more pathways leading to a reduced (rather than a heightened) contraceptive prevalence. The conclusion discusses the implications of those insights for the contraceptive transition, provides a critical perspective of the literature, and draws avenues for future research. [ABSTRACT FROM AUTHOR]

In this article we describe fertility and the sexual aspects of several (pediatric) urological conditions: hypospadias, spina bifida and bladder exstrophy-epispadias. Hypospadias is a very common condition. Especially males with a more severe, proximal hypospadias can develop problems with sexual wellbeing. Approximately 10% experience difficulties with erections and ejaculation. The overall sexual wellbeing seems to be comparable to that of men without hypospadias. Spina bifida patients are sexually active and have just as much sexual desire as the general population. Fertility in general is reduced and female patients need adjusted doses of folic acid preconception. Urine- and fecal incontinence are important negative factors for sexual wellbeing. Bladder exstrophy-epispadias is very rare, but the complexity of this condition requires transition of care and long-term follow-up. Extensive reconstructions may be associated with problems in various phases of life. The cosmetic appearance of the penis is often a point of concern due to a short and wide aspect despite reconstruction. Urological involvement during pregnancy is preferable in mothers with exstrophy. In general, patients with these conditions are in need of good education and guidance. Preferably pro-active, thus initiated by the doctor, and with easy access to a psychologist and/sexologist. [ABSTRACT FROM AUTHOR]

1. This study investigated the potential use of glycerol as a cryoprotectant for quail sperm cells. Its role in maintaining sperm fertilising ability in vivo and in vitro quality parameters, such as motility, was assessed. 2. The data showed that the presence of glycerol in semen samples was associated with infertility, which suggested that removal prior to insemination is mandatory. Removal through serial dilution centrifugation was associated with fewer than 5% of motile sperm cells and resulted in no fertility. 3. In conclusion, glycerol alone is not suitable for quail semen cryopreservation, and other approaches need to be investigated to develop cryobanking programmes for this species. [ABSTRACT FROM AUTHOR]

INTRODUCTION: We aimed to investigate the surgical outcomes following inguinal and subinguinal urologic procedures under deep intravenous sedation (DIVS) with multimodal local anesthesia (LA). METHODS: We conducted a retrospective cohort study from September 2022 to December 2023 including adult patients deemed eligible for day surgery (American Society of Anesthesiologist score 1-3) undergoing radical orchiectomy (RO), microscopic varico- score 1-3) undergoing radical orchiectomy (RO), microscopic varico-celectomy (MV), or microscopic denervation of the spermatic cord (MDSC). All procedures were performed at a single urologic ambulatory surgical center and outpatient clinic, and by a single surgeon (PP). Procedures were performed through a subinguinal or inguinal approach with DIVS and adjunctive multimodal LA. We evaluated intraoperative complications and relevant surgical outcomes and parameters. RESULTS: A total of 103 patients were included in the analysis with a mean age ± standard deviation of 37.3±9.6. This included 25 patients who underwent RO, 54 patients who underwent MV, and 24 patients who underwent MDSC. All procedures were completed successfully without intraoperative complications. Oncologic outcomes were preserved, fertility outcomes improved, and pain scores reduced similarly to the expected rates in the literature. CONCLUSIONS: Our preliminary results demonstrate the safety, effectiveness, and feasibility of performing inguinal and subinguinal urologic procedures under DIVS with LA. These findings suggest that this technique preserves high-quality care while avoiding the unnecessary risks of general or spinal anesthesia, representing an opportunity to transfer these cases outside of hospitals' operating rooms into outpatient ambulatory centers. [ABSTRACT FROM AUTHOR]

To retrospectively analyze the fertility outcomes and prognosis of gestational trophoblastic disease (GTD) patients, providing a basis for targeted fertility guidance and counseling. 82 GTD patients of childbearing age who received treatment at the Obstetrics and Gynecology Department of Lanzhou University First Hospital from January 2016 to January 2023 were stratified into re-pregnancy (n = 20) and non-re-pregnancy (n = 33) cohorts based on their pregnancy outcomes. The impacts of various factors on pregnancy outcomes were subsequently evaluated, encompassing the rates of subsequent pregnancies, live births, miscarriages, ectopic pregnancies, and ongoing pregnancies. Finally, logistics regression model was employed to analyze the risk factors affecting re-pregnancy in GTD patients. The study delineated those patients with different GTD pathologies had varying re-pregnancy rates (mole, erosive mole and choriocarcinoma accounted for 66.04%, 30.19% and 3.77%, respectively). Treatment predominantly involved uterine curettage, with fewer cases receiving chemotherapy alone or in conjunction with curettage accounted for 67.92%, 5.66%, and 26.42%, respectively. The average chemotherapy frequency was 4.59 ± 2.43 sessions, and a majority sought reproductive counseling. Re-pregnancy occurred in 37.74% of patients. The live birth rate was 65.00%, with miscarriage and ectopic pregnancy rates at 25.00% and 5.00% respectively. Logistic regression analysis pinpointed the absence of pre-pregnancy counseling as a significant independent risk factor for re-pregnancy in GTD patients (p < 0.05). While chemotherapy may influence ovarian function, with the majority of patients desiring children post-recovery, pregnancy rates remain high. Fertility counseling significantly enhances re-pregnancy success rates in GTD survivors, emphasizing its recommendation for those aiming to conceive post-recovery. [ABSTRACT FROM AUTHOR]

The article comments on a research paper on puberty suppression with gonadotropin-releasing hormone agonists in transgender and gender-diverse (TGD) youth. Topics discussed include a background on mental health in TGD youth, the use of language for medical professionals in an affirming practice setting, and suppression of puberty in TGD youth.

We develop a spatially-explicit discrete-time model that describes tick population dynamics and incorporates the developmental stages for an individual tick. The model allows for two types of movements across patches: (1) active tick movement and (2) movement of ticks through a host. We analyse the dynamics of the model under a nonlinear fecundity term that exhibits an Allee effect. We show that the system has bounded solutions and, under certain conditions on the parameters, is monotone. Using the next generation matrix approach, we define the net reproductive number of the multi-patch model, $ R(0) $ R (0) , and establish conditions under which $ R(0) $ R (0) determines the local and global asymptotic stability of the extinction equilibrium. We then show that the model exhibits rich dynamics including a monostable equilibrium, multi-stable equilibria, and cycles. Finally, we perform some numerical studies to further examine how dispersal and Allee effects impact tick survival and system stability. [ABSTRACT FROM AUTHOR]

Introduction: This manuscript presents non‐hormonal male contraceptive development in the context of mitigating risk to investigators and investors. Objective: The manuscript uses examples to illustrate drug development principles to move a project from discovery to development. The content is intended for those with reproductive biology backgrounds without significant exposure to drug development—particularly early‐stage targeted drug development—and those with general interest in developing non‐hormonal methods of contraception. Conclusion: The goal of issues addressed in this manuscript is to facilitate the advancement of innovative male contraceptives into late‐stage clinical trials, while keeping in mind early recognition of program deficiencies and development of mitigation strategies, or reassignment of limited, valuable resources. [ABSTRACT FROM AUTHOR]

Purpose: Infertility is a global health issue and nutrition plays a significant role in fertility outcomes. We aimed to investigate the cross-sectional and prospective associations of glycemic index (GI) and glycemic load (GL) with semen quality parameters in a cohort of healthy young men. Materials and Methods: The study included 106 men aged 18–35 years from the FERTINUTS trial. Dietary intake was estimated through 3-day dietary records and several semen parameters were assessed. Multivariable linear regression analysis with the Least Absolute Shrinkage and Selection Operator (LASSO) approach was employed. Results: The cross-sectional analysis revealed positive associations between GI and GL and total sperm count, sperm concentration, and total motility. In the prospective analysis, baseline GI was associated with increases in pH, vitality, immotile sperm or abnormal midpiece and decreases in total sperm count and motility. Conversely, GL was positively associated with changes in vitality and total sperm count. Conclusions: While these findings suggest that GI may have adverse effects on several sperm quality parameters, the results were not consistently observed in the cross-sectional analysis. However, GL was consistently associated with better sperm quality in both analyses. The impact of carbohydrate quality and quantity on fertility remains uncertain and larger prospective studies are needed. [ABSTRACT FROM AUTHOR]

[Display omitted] • Exposure to hypoxia during fetal period had several damages to female ovaries. • Fetal hypoxia led to mitochondrial dysfunction and caused autophagic cell death in granulosa cells (GCs). • Fetal hypoxia damaged GCs function via the abnormal regulation of PI3K/Akt/FoxO singling pathway. • Melatonin supplement could partially recover female ovaries function via improving GCs survival. Fetal hypoxia has long-term effects on postnatal reproductive functions and the mitochondrial impairments of ovarian granulosa cells may be one of the causes. Melatonin applied to mitigate mitochondrial dysfunction and autophagy in mammalian cells has been reported. However, the potential mechanisms by which fetal hypoxia damages reproductive function in neonatal female mice and the melatonin effects on this problem remain unclear. This research aimed to explore the mechanism that fetal hypoxia damages reproductive function in neonatal female mice and attempt to improve the reproductive function by treating with melatonin in vivo and in vitro. We established a fetal hypoxia model and confirmed that fetal hypoxia affects ovarian function by inducing GC excessive autophagy. Transcriptomic analysis, gene interference, cell immunofluorescence, immunohistochemistry and western blot were conducted to explore and verify the underlying mechanisms in mice GCs and KGN cells. Finally, melatonin treatment was executed on hypoxia-treated mice GCs and KGN cells and melatonin injection to fetal-hypoxia-treated mice to determine its effect. The results of in vitro experiments found that fetal hypoxia led to mitochondrial dysfunction in ovarian GCs causing autophagic cell death. And the PI3K/Akt/FoxO pathway mediated the occurrence of this process by transcriptome analysis of ovarian GCs from normal and fetal hypoxia mice, which was further verified in mice GCs and KGN cells. Additionally, melatonin administration prevented autophagic injuries and mitochondrial impairments in hypoxia-treated mice GCs and KGN cells. Meanwhile, in vivo experiments by melatonin injection ameliorated oxidative stress of ovary in fetal-hypoxia-treated mice and improved their low fertility. Our data found that fetal hypoxia causes ovarian GCs excessive autophagy leading to low fertility in neonatal female mice and mitigated by melatonin. These results provide a potential therapy for hypoxic stress-related reproductive disorders. [ABSTRACT FROM AUTHOR]

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Negative associations of health disorders with reproductive performance, often measured with pregnancy per AI or the risk of pregnancy loss, have been demonstrated extensively. Most studies investigated common clinical diseases but did not include subclinical disorders comprehensively. They often evaluated cows subjected to hormonal synchronization protocols for timed AI, limiting the ability to understand how disease may affect spontaneous reproductive function, which is essential for targeted management programs with selective hormonal intervention. It is plausible that metabolic and inflammatory disorders have short- and long-term detrimental effects on different features of reproductive function that result in or contribute to reduced fertility. These may include: (1) re-establishment of endocrine function to promote follicular growth and first ovulation postpartum, (2) corpus luteum (CL) function, (3) estrus expression, and (4) uterine environment, fertilization, and embryonic development. In this narrative literature review, we discuss insights and knowledge gaps linking health disorders with these processes of reproductive function. A growing set of observational studies with adequate internal validity suggest that these outcomes may be affected by metabolic and inflammatory disorders that are common in the early postpartum period. A better characterization of these risk factors in multisite studies with greater external validity is warranted to develop decision-support tools to identify subgroups of cows that are more or less likely to be successful in targeted reproductive management programs. [ABSTRACT FROM AUTHOR]

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Our overarching objective was to characterize associations between genomic merit for fertility and the reproductive function of lactating dairy cows in a prospective cohort study. In this manuscript, we present results of the association between genomic merit for fertility and indicators of metabolic status and inflammation, uterine health, endocrine status, response to synchronization, and estrous behavior in dairy cows. Lactating Holstein cows entering their first (n = 82) or second (n = 37) lactation were enrolled at parturition and fitted with an ear-attached sensor for automated detection of estrus. Ear-notch tissue samples were collected from all cows and submitted for genotyping using a commercial genomic test. Based on genomic PTA values for daughter pregnancy rate (gDPR), cows were classified into a high (Hi-Fert; gDPR >0.6; n = 36), medium (Med-Fert; gDPR −1.3 to 0.6; n = 45), or low (Lo-Fert; gDPR <−1.3; n = 38) group. At 33 to 39 DIM, cohorts of cows were enrolled in the Presynch-Ovsynch protocol for synchronization of estrus and ovulation. Body weights, BCS, and uterine health measurements (i.e., vaginal discharge, uterine cytology) were collected from parturition to 60 DIM, and milk yield was collected through 90 DIM. Blood samples were collected weekly through 3 wk of lactation for analysis of BHB, nonesterified fatty acids (NEFA), and haptoglobin plasma concentrations. Body weight, BCS, NEFA, BHB, and haptoglobin were not associated with fertility groups from 1 to 9 wk after parturition. The proportion of cows classified as having endometritis at 33 to 36 DIM tended to be greater for the Lo-Fert than the Hi-Fert group. The proportion of cows that resumed cyclicity did not differ at any time point evaluated, and there were no significant associations between probability or duration and intensity of estrus with fertility group. Cows of superior genetic merit for fertility were more likely to ovulate, have a functional corpus luteum, have greater circulating progesterone, and have larger ovulatory size than cows of inferior fertility potential at key time points during synchronization of estrus and ovulation. Despite observing numerical differences with potential performance consequences for the proportion of cows that responded to synchronization of ovulation and were both cyclic and responded to the Ovsynch portion of the synchronization protocol, we did not observe significant differences between fertility groups. Although not consistent and modest in magnitude, the collective physiological and endocrine differences observed suggested that cows of superior genetic fertility potential might have improved reproductive performance, at least in part, because of modestly improved endocrine status, uterine health, and ability to ovulate. [ABSTRACT FROM AUTHOR]

Hyaluronan (HA) is a glycosaminoglycan that forms a gel-like barrier in the subcutaneous (SC) space, limiting bulk fluid flow and the dispersion of SC-administered therapeutics. Recombinant human hyaluronidase PH20 (rHuPH20) facilitates the rapid delivery of co-administered therapeutics by depolymerizing HA in the SC space. Administration of rHuPH20 can induce the formation of anti-rHuPH20 antibodies, or anti-drug antibodies (ADAs), with the potential to bind endogenous PH20 hyaluronidase in the adult testes and epididymis. Using a variety of relevant animal models and multiple dose regimens of rHuPH20 across the full spectrum of animal development, we demonstrated that rHuPH20 administration resulted in the formation of ADAs. Although these ADAs can bind both the recombinant rHuPH20 enzyme and recombinant versions of animal model-specific hyaluronidases, they had no impact on fertility parameters (as measured by sperm concentration and motility, litter size, and litter viability) or fetal development. We present the result of our nonclinical studies in order of the developmental lifecycle, beginning with adults. Toxicology studies that extend beyond the standard package are also presented. These studies demonstrate the favorable safety profile of rHuPH20 and ADAs in nonclinical models. Additionally, we identified substantial safety margins for clinically relevant doses of rHuPH20. [Display omitted] • rHuPH20 facilitates subcutaneous administration of therapeutics. • Impact of rHuPH20 and anti-drug antibodies observed in multiple nonclinical models. • rHuPH20 anti-drug antibodies did not negatively alter fertility or development. • Substantial safety margins were identified when compared to human-equivalent doses. • Studies support favorable safety profile of rHuPH20. [ABSTRACT FROM AUTHOR]

This article interrogates the impacts of different types of family benefits expenditures on the positive relationship between female employment and fertility rates in developed welfare states. It does this by theorizing how these family benefits align with welfare state regimes' preferences for different normative gender-role ideologies. Rather than treating family benefits as a monolith, this article investigates the impact of disaggregated expenditures in the Organisation for Economic Co-operation and Development (OECD) family policy database (1. services and in-kind benefits, 2. child-related cash benefits and 3. tax-based financial support for children) on both female employment and fertility rates. This is done using pooled time-series analysis covering the period 2000–9. The analysis yields evidence that expenditure most reflecting a 'full egalitarian' gender ideology including service and in-kind benefit provision has the most positive association with female employment and fertility due to an emphasis on defamiliarization. The picture for child-related cash benefits is mixed due to the presence of cash transfer provisions not employment-contingent captured in the indicator. In contrast, tax-based financial support for children harms female employment, reflecting a maternalistic 'traditional' ideological orientation, but is positive for fertility rates indicating a moderate pro-natal effect of tax-based financial support for children. [ABSTRACT FROM AUTHOR]

• General practitioners (GPs) play a pivotal role in managing infertility in Ireland. • Ireland has a new publicly funded assisted reproductive technology (ART) scheme. • We investigate GP's knowledge of fertility and opinions of ART referral criteria. • GPs feel the ART access criteria are too narrow and that they need more education. • Access to fertility treatment globally remains highly inequitable. Global access to assisted reproductive technologies (ART) remains highly inequitable. Until recently, access to ART in Ireland was solely available through private fertility clinics. Publicly funded ART was introduced in September 2023 but eligibility requires patients to meet strict access criteria that include referral by their primary care general practitioner (GP) to the local fertility service. Previous studies report that fertility training amongst doctors, including GPs, is variable and an obstetrics and gynaecology (O&G) rotation is not mandatory for GP trainees in Ireland. This study aimed to investigate GPs' knowledge of fertility investigations and management, as well as attitudes towards publicly funded ART access criteria. A cross-sectional online survey was distributed to GPs working in Ireland between September 2023 and January 2024. The survey questionnaire explored attitudes to, and knowledge of, ART including the publicly funded access criteria. Responses to free-text questions were qualitatively analysed using content analysis. The study had 154 respondents, representing approximately 4 % of GPs in Ireland. Three quarters (n = 120, 78 %) of respondents were female, 68 % (n = 105) had completed an O&G training rotation and 72 % (n = 111) had further O&G qualifications. However, 69 % (n = 107) reported that they had no training in subfertility investigation and management, and 34 % (n = 53) were not aware of the access criteria for publicly funded ART prior to completing the survey. Almost all GPs (97 %, n = 149) felt that they would benefit from more education on fertility. Qualitative content analysis generated two themes regarding publicly funded ART: (i) the access criteria are too restrictive and (ii) the workload for GPs will increase. GPs in Ireland are now being tasked with managing infertility and fertility treatment referrals, but most have not been provided with sufficient training. Our study shows that GPs in Ireland desire broader access criteria for publicly funded ART and better fertility training and education for their own clinical practice. [ABSTRACT FROM AUTHOR]

The European Board and College of Obstetrics and Gynaecology (EBCOG) and the European Network of Trainees in Obstetrics and Gynaecology (ENTOG) express their concerns on the effect of climate change and environmental pollution. This paper reviews the impact on reproductive health and the contribution to climate change by the field of obstetrics and gynaecology. It concludes that its contributors and the effects of climate change cause definite adverse consequences to fertility and adverse obstetric outcomes. Mankind, and obstetrics and gynaecology personnel as well, must be aware and responsible of its contribution to climate change and consider the impact of their actions and interventions. [ABSTRACT FROM AUTHOR]

We develop an overlapping generations model to explore the role of grandparents in grandchildren's education and its impact on human capital growth. We examine the quantity–quality (Q–Q) trade-off faced by parents in choosing the number and education of children, incorporating an active role for grandparents. Findings underscore the significance of the elderly in human capital accumulation, fertility, and economic growth. When grandparents invest more time, resources are freed, fostering greater human capital growth and mitigating the effects of the Q–Q trade-off. • Overlapping generations models can model active aging. • The trade-off between quantity and quality of children is a crucial topic in human fertility theories. • Active aging can influence the educational process. • Grandparents can play a fundamental role in educating their grandchildren. • Grandchildren with a higher level of education imply a higher human capital and foster economic growth. [ABSTRACT FROM AUTHOR]

Summary: Obesity potentially reduces fertility, but systematic reviews are lacking to summarize the existing literature. Therefore, we systematically summarized the association between preconception body mass index (BMI) and fertility in adult female based on existing reports. Up to September 2023, we conducted literature retrievals in different databases, including Web of Science, PubMed, Wiley, and ScienceDirect. Finally, 18 studies were included. Female with overweight/obesity (FOR = 0.85; 95% CI: 0.80, 0.90), obesity (FOR = 0.76; 95% CI: 0.69, 0.83), and overweight (FOR = 0.93; 95% CI: 0.88, 0.99) was associated with the significant time‐to‐pregnancy (TTP) prolongation (reduced fecundability). Interestingly, underweight was moderately associated with prolonged TTP in females (FOR = 0.95; 95% CI: 0.91, 0.99). Female overweight/obesity was associated with an increased risk of subfecundity (OR = 1.44; 95% CI: 1.20, 1.72) and infertility (OR = 1.60, 95% CI: 1.31–1.94). The findings emphasize the importance of considering appropriate preconception BMI at the population level for female fertility outcomes. In particular, prepregnancy obesity in females is strongly associated with prolonged TTP and increased risk of subfecundity. Scientific management of preconception BMI may improve fertility. [ABSTRACT FROM AUTHOR]

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We conduct a randomized controlled trial that provides pregnant and immediate postpartum women with improved access to family planning through counseling, free transportation to a clinic, and financial reimbursement for family planning services over two years. We study the effects of our intervention on child growth and development outcomes among 1,034 children born to participating women directly before the intervention rollout. We find that children born to mothers assigned to the family planning intervention arm were 0.28–0.34 standard deviations taller for their age and 10.7–12.0 percentage points less likely to be stunted within a year of exposure to the intervention. Children born to mothers assigned to the intervention arm also scored 0.17–0.20 standard deviations higher on a caregiver-reported measure of cognitive development after two years of intervention exposure. Although the nonmeasurement of children is a challenge in our study, our estimates are robust to multiple methods of correcting for potential attrition bias. Our results are consistent with models of fertility that link couples' fertility decisions to child health and human capital. Our results also suggest that improved access to family planning might have positive downstream effects on child health beyond contraceptive use and fertility outcomes. [ABSTRACT FROM AUTHOR]

Despite recent economic growth and reductions in child mortality in many African countries, the region has experienced a slow fertility transition. In this study, we explore whether the slow structural economic change on the continent can explain this discrepancy. We construct a unique panel dataset combining Demographic and Health Surveys and nighttime light intensity data (an indicator of industrialization) from 57 countries at the subnational region level over three decades to analyze the drivers of fertility transitions across low- and middle-income countries. Our results confirm that household wealth, reduced child mortality, and female primary education are crucial for fertility declines. However, our analysis also highlights the importance of indicators of structural economic change, including the share of labor in nonagricultural occupations, industrialization, the share of women with higher education, and the formalization of the economy. Our simulations suggest that if high-fertility countries in sub-Saharan Africa underwent structural economic transformations comparable to those of other low- and middle-income countries with low fertility rates, their fertility levels could fall by 1 to 1.6 children. [ABSTRACT FROM AUTHOR]

Drawing on more than 30 years of nationally representative microdata from the General Social Survey, this article comprehensively updates recent trends in ideal family size in the United States. It first documents stability in ideal family sizes between the mid-1980s and 2018, even in the face of a recent fertility decline. Next, the study adopts a latent class approach that identifies typologies of "reproductive orientations," defined as multidimensional mental models of reproduction encompassing ideal family size, attitudes toward reproductive labor, and views on reproduction contexts. The findings indicate three distinct classes of reproductive orientations: Progressive Familialists, Conservative Familialists, and Blended Egalitarians. Further analyses suggest that the prevalence of these classes has changed over time and that class membership is associated with distinct patterns of childbearing and marriage. These findings deepen contemporary understandings of ideal family size in the United States and have broader implications for how demographers conceptualize and measure fertility preferences across diverse contexts. [ABSTRACT FROM AUTHOR]

Multiple births strain mothers' and families' resources in ways that should highlight preferences for family size, birth spacing, and parity-dependent stopping behavior. Couples with surviving twins reach their target family size sooner than other couples and should be more likely to practice family limitation. Twins are also a greater burden on the mother's time and health, which could lead to postponing the next birth, even among couples who want additional children. We examine these hypotheses by analyzing families with twins in the 1900 and 1910 U.S. Censuses. Using reconstructed birth histories for more than 7 million women in the IPUMS full-count 1900 and 1910 datasets and event-history methods (Kaplan–Meier curves, cure models), we find clear evidence of family limitation following a multiple birth. Couples who had twins or triplets were more likely to stop childbearing, and those who continued having children delayed their next birth. Responses to multiple births were larger in groups previously identified as leaders in the transition to smaller families, and roughly one third of couples stopped after one or two children. We find no evidence that some groups relied primarily on birth spacing to reduce family size while others relied primarily on stopping. [ABSTRACT FROM AUTHOR]

While parity is a significant factor influencing parental health, its relationship with dementia remains underexplored. This research note advances the literature by conducting a well-powered analysis of associations between parity (i.e., number of children) and Alzheimer's disease and dementias (AD/D) status in large-scale population data. The data contain a large number of AD/D cases (37,228 women and 19,846 men), allowing a range (1–10) of parity associations to be estimated precisely. Using proxy (adult child's) reports of parental AD/D status, we find that both fathers and mothers with grand multiparity have decreased odds of AD/D status, and the effect sizes become larger as parity increases, with 30–40% reduction in AD/D status at parities above 7. The association is stronger for mothers than for fathers. This finding differs from much of the prior literature and likely suggests the impact of parity, as one of the important life course contexts, on people's cognitive function and risk of having AD/D. Finally, we include population projections that consider how large changes in parity distributions over time may contribute to small elevations in AD/D rates. [ABSTRACT FROM AUTHOR]

The American hoverfly Eupeodes americanus (Wiedemann) (Diptera: Syrphidae) is an aphidophagous predator during its larval stage and is currently being evaluated for inclusion in biocontrol programs as a new biocontrol agent. However, little is known about its reproductive aptitudes. The objective of the present study was to determine the reproductive parameters of E. americanus and to compare them with those of a commercialized and widely used biological control agent for aphids, the aphid midge Aphidoletes aphidimyza (Rondani) (Diptera: Cecidomyiidae). The preoviposition period, oviposition period, adult longevity, lifetime and daily fecundity, egg hatching rate, and fertility were determined for E. americanus females and compared to those of A. aphidimyza. Trials were conducted under laboratory conditions in rearing cages on the broad bean plant Vicia faba L. (Fabaceae), infested with pea aphids Acyrthosiphon pisum (Harris) (Hemiptera: Aphididae). The results revealed that the preoviposition period, oviposition period, and adult longevity were significantly longer in E. americanus than in A. aphidimyza. The daily fecundity and egg-hatching rate were similar in both species. However, lifetime fecundity and fertility were considerably higher in E. americanus than in A. aphidimyza. This study demonstrates that the reproductive capacity of E. americanus is clearly superior to that of A. aphidimyza and therefore supports its inclusion in the aphid pest management program as a new biocontrol agent. [ABSTRACT FROM AUTHOR]

This paper investigates the association between accumulated experiences in the working and parenting spheres and retirement timing among Spanish women, utilizing data from the Survey of Health, Ageing and Retirement in Europe (SHARE). The study examines whether labor market attachment or cumulative disadvantage characterizes women's retirement and how these factors relate with the number of children. Firstly, multichannel sequence analysis and cluster analysis were employed to identify distinct work–family life courses from ages 20 to 50. Seven clusters were identified: "Full-time work with 2+ children," "Out of the labour force and 2+ children," "Mid-life discontinuity and 2+ children," "Full-time work and 1 child," "Full-time work and childless," "Part-time work and 2+ children," and "Part-time work or out of the labor force and 1 child." Secondly, the study examines the association between these identified groups and retirement timing. The results indicate that Spanish women who have experienced more unstable careers characterized by extended periods of inactivity or part-time work, particularly in combination with having 2 or more children, are more likely to retire at a later age compared with women with continuous careers, with or without children. These findings underscore the ongoing challenges of balancing unpaid care work and wage work in Spain, while also revealing notable variations among women. [ABSTRACT FROM AUTHOR]

The stink bugs Acrosternum arabicum Wagner and Brachynema germari Kolenati (Hemiptera: Pentatomidae) damage developing pistachio nuts in Iran. Ooencyrtus egeria Huang and Noyes (Hymenoptera: Encyrtidae) parasitizes eggs of both species, alternating between them seasonally. We compared the biological and life history attributes of O. egeria reared for 3 generations on each host species with those that had been transferred to the alternate host for 2 generations. We also tested female responses to host egg density. Eggs of B. germari were parasitized at higher rates and yielded faster wasp development, heavier female progeny with greater fecundity, and a more female-biased sex ratio, than eggs of A. arabicum. Rearing on A. arabicum did not diminish wasp fitness on B. germari , and the F1 progeny of wasps switched to A. arabicum inherited some beneficial parental effects from rearing on B. germari. Regardless of host species, females parasitized fewer eggs in 8 h as density increased from 10 to 30 eggs, but progeny sex ratio (% female) increased. The anomalous response to host density appears to arise from a combination of behavioral and egg load constraints. Females mature only 10–12 eggs per day. Carefully inspect egg clusters before selecting the most suitable eggs for oviposition, a more time-consuming process for large clusters. Our results indicate that rearing O. egeria on eggs of A. arabicum , which are more convenient and cost-effective to produce than those of B. germari , will not diminish its performance on B. germari following augmentative release, beyond a slight reduction in female fecundity. [ABSTRACT FROM AUTHOR]

BACKGROUND: The parasitic mite, Varroa destructor has posed a threat to the health and survival of European honey bees, Apis mellifera worldwide. There is a prevailing belief that small comb cells could provide a management tool against Varroa mites. However, the hypothesis that smaller cells can impede Varroa reproduction has not been fully tested. Here, we tested this hypothesis under laboratory conditions by using two distinct Varroa in vitro rearing systems: one involved gelatin capsules of different sizes, specifically size 00 (0.95 mL) versus size 1 (0.48 mL), and the second consisted of brood comb cells drawn on 3D printed foundations with varying cell sizes, ranging from 5.0 mm to 7.0 mm at 0.5 mm intervals. RESULTS: The results showed that mother mites in size 00 cells had significantly lower fecundity and fertility compared to those in size 1 cells. Interestingly, the reproductive suppression in larger cells could be reversed by adding an extra worker larva. Similarly, gonopore size of mother mites was smaller in size 00 cells, but restored with another host larva. Furthermore, both the fecundity and fertility of mother mites decreased linearly with the size of brood comb cells. CONCLUSIONS: Our results suggest that the reproduction of V. destructor is hindered by larger cells, possibly because larger brood cells disperse or weaken host volatile chemical cues that are crucial for Varroa reproduction. The insights derived from this study are expected to hold significant implications for the implementation of Varroa management programs. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Understanding the intricacies of pollen tube growth in cereal crops, such as rice, is crucial for understanding crossbreeding, seed formation, and crop productivity. In this study, we investigated the molecular mechanisms underlying pollen tube germination and elongation in rice, focusing on the interaction between OsPUB14 and OsMTD2 and its impact on reactive oxygen species (ROS) regulation. Expression studies revealed that OsPUB14 was highly expressed in pollen and anther tissues, indicating its involvement in pollen function. We demonstrated that OsPUB14 belonging to group II U-box domain proteins, interacts with the kinase domain of OsMTD2 (a pollen-specific CrRLK1L member) and degrades it. This interaction subsequently reduces OsMTD2-mediated ROS generation. Moreover, the overexpression of OsPUB14 resulted in decreased ROS levels and reduced fertility in rice plants, emphasizing its role in reproductive processes. Yeast two-hybrid screening identified OsCRK10P and OsNET2D as potential interactors of OsPUB14, further expanding our understanding of the regulatory networks associated with pollen development. This study provides insight into the intricate interplay between pollen-specific plant U-box domain proteins (PUBs), demonstrating their roles in regulating ROS levels and ultimately influencing plant fertility. [ABSTRACT FROM AUTHOR]

Fertility has declined in many rich societies after 2010. However, the factors that explain this fertility decline remain poorly understood. In particular, little is known about how changes on the housing market contributed to the fertility decline. This study examines the links between house prices and fertility in the Netherlands, a country where house prices have risen dramatically in the past decade. Regional (NUTS 3) data for the period 1995–2022 are analysed using within‐between models. The results for the within‐effect of house prices show that after 2010, fertility decreased (more) in regions where house prices increased (more), suggesting that the housing crisis in the Netherlands can explain a substantial part of the post‐2010 fertility decline. Before 2010, however, increases in regional house prices were associated with small increases in fertility, showing that the direction of the within‐effect of house prices depends on the time period that is studied. Finally, differences in house prices between regions are not consistently associated with fertility. [ABSTRACT FROM AUTHOR]

Despite a large literature on the importance of childhood neighbourhoods for life course transitions, there is a lack of fertility studies combining a life‐course perspective with detailed neighbourhood measures. Addressing this gap, we use longitudinal data in which the entire population of a Swedish town is geocoded at the address‐level, 1939–1967, and linked to national registers from 1968 to 2015. We study how social neighbourhoods in childhood influence fertility outcomes by constructing individual neighbourhoods at the address level to measure the social class of nearby childhood neighbours. We analyse the age at first and last birth, children ever born, birth spacing and childlessness. Growing up in higher‐status neighbourhoods is associated with delayed fertility for both men and women, but no association is found for the number of children ever born or for childlessness. Associations are stable over time, and later ages of neighbourhood exposure matter more, especially for men. Contrary to prior literature's focus on the lower classes, our results are driven by higher‐status individuals growing up in distinctly white‐collar neighbourhoods. [ABSTRACT FROM AUTHOR]

Although the overall incidence and mortality of colorectal cancer have declined, diagnosed cases of young-onset colorectal cancer have increased significantly. Concerns about future fertility are second only to concerns about survival and may significantly affect the quality of life of young cancer survivors. Fertility preservation is an important issue in young-onset colorectal patients with cancer undergoing oncotherapy. Here, we discussed the effects of different treatments on fertility, common options for fertility preservation, factors affecting fertility preservation and improvement measures, and the relationship between fertility and pregnancy outcomes in young-onset colorectal patients with cancer. [ABSTRACT FROM AUTHOR]

Although family scholars have long relied on longitudinal data, electronic methods of data collection like web‐ and app‐based surveys have greatly increased the amount of data with many repeated measures at short intervals, sometimes called intensive longitudinal data. The authors provide a conceptual overview of this type of data, paying particular attention to the appropriate frequency for the intervals, and discuss some of the unique contributions to Life Course Theory that can be generated with such data. They illustrate two analytic techniques that especially benefit from an intensive longitudinal design—sequence analysis and between‐within regression—by applying these methods to intensive longitudinal data from the Relationship Dynamics and Social Life Study that represent a "micro life course" of pregnancy risk (partnering, pregnancy desire, sex, and contraception) during the transition to adulthood. Their sequence analysis shows that singlehood, hormonal contraception, or partnered abstinence dominated most young women's micro‐life courses. Black/African‐American young women's micro life courses were similarly dominated by singlehood but were even more frequently dominated by partnered abstinence than their non‐Black/African‐American peers'. However, Black/African‐American women's micro life courses were less stable, potentially explaining their higher undesired pregnancy rates. A between‐within regression model shows that Black/African‐American coital contraceptors were less likely than their non‐Black/African‐American peers to use withdrawal (rather than condoms). They conclude by suggesting some potential ways that intensive longitudinal data capturing micro‐life courses can contribute to important outstanding research questions in family research. [ABSTRACT FROM AUTHOR]

Subsurface carbon storage reflects the fertility of mangrove sites. Site fertility has implications for site health. The aims of this study, among others, are to determine the content of C-organic sediments, determine the litter carbon content, and understand the effect of C-organic and litter carbon on on-site health (soil pH and CEC). The stages of research, among others, are sediment and litter sampling on the observation plot, analysis of sediment and litter samples in the laboratory, calculation of litter carbon by dry weight, and fertility analysis of site health using multiple linear regression analysis with a significant threshold of 95%. Based on the results of the study, the highest C-organic content was observed in cluster plot 3 (CL3); the highest increase in litter carbon was at CL2, and there was a significant effect between site fertility (C-organic) and site health (pH). The pH and carbon play a role in the mobility of compounds that form organic materials. Factors influencing on-site carbon health conditions include waste production, organic material, temperature, tree species, pollution, and climate. Sediment conditions affect sigh in organic matter and the health of the site. The results of this research can illustrate the fertility and health conditions of sites in mangrove forests, so regulations can be formulated to prevent damage to mangroves. [ABSTRACT FROM AUTHOR]

Copyright of Die Gynäkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Die Gynäkologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the last five decades, almost all European countries have experienced a decline in actual fertility, but not in desired fertility. The incompatibility of motherhood and paid work has been identified as one of the main drivers of women's unrealized fertility desires. Regular grandparental childcare might reduce mothers' work–family conflicts, increasing their chances of having a second birth. An extensive literature has estimated the role of grandparenting in adult children's fertility. However, less attention has been devoted to the direct role of regular grandparental childcare, which is among the main resources in women's reconciliation strategies. This article contributes to this debate by estimating the causal effect of regular grandparental childcare on women's chances of having a second child. Using data from the first five waves of the Millennium Cohort Study, I implement an instrumental variable approach. I observe a strong and positive effect of regular grandparental childcare on women's likelihood of having a second birth. This effect remains strong and positive net of women's partnership status and income and educational levels. These results highlight the importance of the affordability and the availability of childcare for the decision to have a second child and the need for more supportive childcare policies. [ABSTRACT FROM AUTHOR]

Calorie restriction has many beneficial effects on healthspan and lifespan in a variety of species. However, how late in life application of caloric restriction can extend fly life is not clear. Here we show that late-life calorie restriction increases lifespan in female Drosophila melanogaster aged on a high-calorie diet. This shift results in rapid decrease in mortality rate and extends fly lifespan. In contrast, shifting female flies from a low- to a high-calorie diet leads to a rapid increase in mortality and shorter lifespan. These changes are mediated by immediate metabolic and physiological adaptations. One of such adaptation is rapid adjustment in egg production, with flies directing excess energy towards egg production when shifted to a high diet, or away from reproduction in females shifted to low-caloric diet. However, lifelong female fecundity reveals no associated fitness cost due to CR when flies are shifted to a high-calorie diet. In view of high conservation of the beneficial effects of CR on physiology and lifespan in a wide variety of organisms, including humans, our findings could provide valuable insight into CR applications that could provide health benefits later in life. [ABSTRACT FROM AUTHOR]

Subfertility is a multifactorial disorder that affects the rabbit production industry. However, subfertility may be treated by using a simple intervention such as vitamin supplementation. Vitamin E and selenium (Se) are potent antioxidants that protect the male reproductive system. The aim of this study is to determine the effects of vitamin E and Se on testicular size, semen quality and freezability, antioxidant activity, testosterone levels, and fertility in subfertile rabbits. Twenty-one New Zealand rabbits were classified as subfertile rabbits based on their semen characteristics and fertility records. The rabbits were randomly allocated into 3 equal groups (G1: control; G2: injected with Vit E 100 IU/head + Se 0.1 mg/kg b.w.; G3: injected with Vit E 200 IU/head + Se 0.2 mg/kg b.w. once weekly for 8 weeks).Once weekly for 8 W, blood samples were collected to measure serum testosterone level and total antioxidant capacity (TAC), and semen samples were collected by artificial vagina to assess the quality of fresh and frozen semen. At the 8th week of the study, 150 multiparous does were artificially inseminated with fresh semen to assess the fertility of rabbits after treatment; 50 does for each group. At the end of the study, rabbits were slaughtered to assess testicular morphometry. Fresh and post-thaw semen quality parameters were significantly (p < 0.05) higher in G3in comparison with G2and G1, respectively. Also, testosterone level was significantly (p < 0.05) increased at the 2nd week in G3in comparison with other groups. Conception and kindling rates were significantly (p < 0.05) higher in does which were inseminated with semen fromG3. In conclusion, injection of vitamin E and selenium at a higher dose (G3) improved the testicular morphology, quality of fresh and post-thaw semen, and most importantly, the fertility of subfertile rabbits. [ABSTRACT FROM AUTHOR]

Here we report the case of a cow with two ovaries that each exhibited hyperplasia but that otherwise had normal gross morphology. Both ovaries had a large number of tertiary follicles on the ovarian surface. Oocytes from one ovary were studied in more detail. The transcriptome was largely similar to other oocytes. Oocytes could undergo cleavage at a rate consistent with other oocytes and result in blastocyst-stage embryo formation after in vitro maturation and fertilization. Review of the literature from cattle and other species did not reveal reports of a similar type of spontaneous ovarian abnormality. Whole genome sequencing revealed many single nucleotide polymorphisms with predicted large effects on protein structure that could potentially be causative for the phenotype. The variant considered most likely to cause the observed alteration in ovarian function was a mutation in the glycoprotein-modifying enzyme MAN1A2. [ABSTRACT FROM AUTHOR]

This paper examines how households reacted to the dismantling of the one-child policy, which China relaxed in 2013 and eliminated prior to 2017. We use household survey data and a series of regressions to show that birth rates, female labor force participation, and household saving rates have already changed. Between 2015 and 2017, the proportion of households with children having more than one child increased by at least five percentage points. Moreover, within households adding another child, female labor force participation and saving rates significantly decreased. Our paper contributes to the empirical literature on the economic impacts of pro-fertility policies and has implications for the theories of why households save. [ABSTRACT FROM AUTHOR]

This is the first large-scale comparative study to search for macro-level determinants of the realization of short-term fertility intentions across European countries. Using the unique follow-up feature of the Generations and Gender Survey and adopting rigorous definitions of intentions and outcomes, it reports on the level of fulfilment and finds clear heterogeneity across European countries. Using a multilevel, multivariate approach, it examines the nature of macro-level factors that may explain differences in the realization of fertility intentions. Based on our analysis, we conclude that labour market stability (as measured by fluctuations in the unemployment rate), price stability, heavy welfare state involvement, and the dominance of certain attitudinal conditions all support the greater realization of short-term fertility intentions. [ABSTRACT FROM AUTHOR]

The link between gender equality and fertility has been the topic of a growing literature. Using data from the International Social Survey Program (ISSP) of 2012 (n = 27,062 individuals, 39 countries), and applying multi-level modelling techniques, we explored the associations between individual gender egalitarian attitudes, societal gender equality and fertility ideals. The results show that individual gender egalitarianism is negatively associated with fertility ideals even across a broad set of countries from different regions. Additionally, we find that while societal gender equality is positively associated with fertility ideals, we also observe a small but statistically significant interaction effect between individual attitudes and societal gender equality. The cross-level interaction suggests that the negative fertility implications of individual egalitarian attitudes are amplified rather than mitigated in gender equal contexts. Thus, while the findings point to the potential importance of context and societal gender equality, they do not clearly confirm dominating theories. In future, the interplay between individual attitudes and societal support should be further explored in cross-country research, and more studies should include countries from the global South. [ABSTRACT FROM AUTHOR]