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412 results on '"Feng, Fengqin"'

79. Novel Gut Microbiota Patterns Involved in the Attenuation of Dextran Sodium Sulfate-Induced Mouse Colitis Mediated by Glycerol Monolaurate via Inducing Anti-inflammatory Responses

Author

Mo, Qiufen, primary, Liu, Tao, additional, Fu, Aikun, additional, Ruan, Shengyue, additional, Zhong, Hao, additional, Tang, Jun, additional, Zhao, Minjie, additional, Li, Yang, additional, Zhu, Songming, additional, Cai, Haiying, additional, and Feng, Fengqin, additional

Published
2021
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83. The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies.

Author

Wang, Jing, Chen, Yong, Zhong, Hao, Chen, Fang, Regenstein, Joe, Hu, Xiaosong, Cai, Luyun, and Feng, Fengqin

Subjects
GUT microbiome, PROBIOTICS, HYPERURICEMIA, INTESTINAL absorption, URIC acid, METABOLIC disorders
Abstract

Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA) metabolism, which is a complex physiological process involving multiple organs (liver, kidney, and intestine). Although UA metabolism in the liver and kidneys has been elucidated, only a few studies have focused on the process in the intestine. With our growing knowledge of the effects of gut microorganisms on health, the gut microbiota has been identified as a new target for HUA treatment. In this review, the relationship between HUA and the gut microbiota is elucidated, and anti-hyperuricemia mechanisms targeting the intestine are discussed, such as the promotion of purine and UA catabolism by the gut microbiota, increases in UA excretion by the gut microbiota and its metabolites, regulation of UA absorption or secretion in the intestinal tract by certain transporters, and the intestinal inflammatory response to the gut microbiota. Additionally, probiotics (Bifidobacteria and Lactobacilli) and prebiotics (polyphenols, peptides, and phytochemicals) with UA-lowering effects targeting the intestinal tract are summarized, providing reference and guidance for further research. [ABSTRACT FROM AUTHOR]

Published
2022
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89. Dietary medium‐chain 1‐monoglycerides modulates the community and function of cecal microbiota of broilers.

Author

Liu, Tao, Guo, Liangyong, Zhangying, Ye, Ruan, Shengyue, Liu, Wangxin, Zhang, Xi, and Feng, Fengqin

Subjects
MICROBIAL metabolites, SHORT-chain fatty acids, AMINO acid metabolism, MICROBIAL metabolism, GUT microbiome, EGG incubation, BUTYRIC acid
Abstract

BACKGROUND: Medium‐chain monoglycerides (MGs) are a group of 1‐monoglycerides of medium‐chain fatty acids with strong antibacterial activity, which may influence the gut microbiota in the diet of broilers. The present study evaluated the effects of mixed MGs on the community and function of gut microbiota in broilers. A total of 528 newly hatched male yellow feathered broiler chicks were weighed and randomly assigned into four groups, including a basal diet (CON), a basal diet containing 300 mg kg−1 MG (MG300), 450 mg kg−1 MG (MG450), or 600 mg kg−1 MG (MG600). RESULTS: The cecal acetic acid, propionic acid, butyric acid, isobutyric acid, isovaleric acid and total short‐chain fatty acid of broilers in the MG‐containing groups were notably increased compared with the CON group. Dietary MG selectively increased the relative abundance of Bifidobacteriaceae, Bacteroides and an unclassified genus of Lachnospiraceae family, but decreased the proportion of an unclassified genus of Barnesiellaceae and a norank genus of Flavobacteriaceae family in the cecum of broilers. Functional prediction revealed that MG supplementation enriched the microbial gene abundance of amino acid metabolism and carbohydrate metabolism, while depleted the gene abundance of fat metabolism and energy metabolism. Moreover, the modulation of gut microbiota by MG supplementation was closely correlated with the alteration of muscle amino acids. CONCLUSION: Dietary MGs altered the gut microbiota community structure and metabolites, and modulated the gene abundance of microbial metabolism pathways in the cecum of broilers, which may further influence the growth performance, nutrient utilization and meat quality of the host. © 2021 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Published
2022
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94. Sea cucumber (Acaudina leucoprocta) peptides exhibit anti-aging effect in Drosophila melanogastervia regulation of microbiota dysbiosis and metabolic disorder

Author

Wang, Qianqian, Zhang, Junhui, Shen, Fei, Du, Juan, and Feng, Fengqin

Abstract

As the population ages, the pursuit of extended lifespan and improved healthspan has gained significance. This study assessed the anti-aging properties of sea cucumber peptides derived from Acaudina leucoprocta(SCP) through microbiome and metabolome analyses in Drosophila melanogaster. Supplementation with 0.2%, 0.4%, 0.6%, and 0.8% of SCP significantly boosted the survival rate and extended the mean and median lifespans in both male and female flies. Among them, 0.6% SCP treatment extended the mean and median lifespans of male flies by 21.01% and 25.48 %, which showed the most prominent lifespan-prolonging effect. Moreover, SCP enhanced the healthspan of male flies by improving their climbing ability, intestinal barrier function, and memory performance. Additionally, SCP boosted the survival rate of flies subjected to oxidative, starvation, and heat stress, with no significant effect observed under cold stress conditions. The lifespan-extension effect of SCP remained unaffected by dietary restriction, but was partially inhibited when provided with antibiotic-supplemented food. SCP modulated microbiota with increased the abundance of Lactobacillus, Rhodococcus, and Propioniciclavaand decreased Acetobacter, Achromobacter, Pedobacter, and norank_f_Saprospiraceae, which closely related with lifespan-extension effect. Furthermore, SCP induced a metabolic profile in 30-day-old flies more akin to that of 3-day-old flies, impacted 13 significantly regulated metabolites associated with amino acid, nucleotide, and carbohydrate metabolisms. These findings highlight SCP intervention as a promising anti-aging strategy.

Published
2024
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