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A 9-year-old domestic cat, positive for antibodies to feline immunodeficiency virus (FIV), was brought to a veterinary clinic with alopecia, ulcerative skin lesions, and upper respiratory tract (URT) signs. This was after being treated for suspected allergic dermatitis, without clinical improvement, for 2 y. Biopsy of the skin and fine-needle aspirates of the spleen and of the lymph nodes were taken which detected the presence of Leishmania amastigotes. Leishmania infection was further confirmed by detection of a high titer of anti-Leishmania antibodies (≥ 3200) with an indirect fluorescent antibody technique (IFAT) serology. After the diagnosis of feline leishmaniosis (FeL) was made, allopurinol and meglumine antimoniate were started and led to quick and complete clinical improvement. After 7 mo, allopurinol administration was briefly interrupted but was resumed following relapse of the skin lesions. One month later, the cat was treated for suspected acute kidney injury, which prompted reduction of the total daily dose of allopurinol by 50%. The cat remained clinically well, with complete resolution of the cutaneous and URT signs, for nearly 24 mo after the diagnosis of FeL; at which point it was euthanized for worsening cardiac disease. To our knowledge, this represents a rare case of successful treatment of FeL with a suspected nephrotoxic effect associated with long-term use of allopurinol. Further studies are required to clarify the relationship, if any, between leishmaniosis and congestive heart failure in cats.

In 1919, the Uruguayan artist Torres-Garc��a moved from Barcelona to New York. In the experimental works that he produced during his two-year stay in the city, the artist presented New York and the bodies inhabiting it as inextricable from one another and mutually defining, enmeshed within the same urban fabric. He did so especially through references to fashion, depicting the articles of clothing worn by New Yorkers as extensions of the city���s morphology. By drawing upon the social functions of actual fabrics, Torres-Garc��a connected bodily and architectural surfaces to negotiate his ambivalence towards the demands of New York���s capitalist society on its denizens. This article investigates the artist���s constant oscillation between adhering to and undermining the conformity and mechanization that he attributed to New Yorkers. I argue that, through his interventions into the realm of fashion, Torres-Garc��a negotiated the urban individual���s potential to either adhere to the rhythms and lifestyles imposed by the city or resist them by playing with socio-economic signs and multiple identities. I show that this unresolved tension echoes with Torres-Garc��a���s writings from this period, illuminating the artist���s conflicted relationship with the city., Miradas - Journal for the Arts and Culture of the Am��ricas and the Iberian Peninsula, Bd. 6 (2022): Miradas

En 1919, el artista uruguayo Torres Garc��a se mud�� de Barcelona a Nueva York. En los trabajos experimentales que produjo durante su estancia de dos a��os en la ciudad, el artista present�� a Nueva York y a los cuerpos que lo habitaban, como inseparables uno del otro y definidos mutuamente, enredados en el mismo tejido urbano. Particularmente lo hizo a trav��s de las referencias a la moda, representado los art��culos de vestir de los neoyorquinos como extensiones de la morfolog��a de la ciudad. Bas��ndose en las funciones sociales de las telas, Torres Garc��a conect�� superficies corp��reas y arquitect��nicas para gestionar su ambivalencia hacia las demandas de la sociedad capitalista de Nueva York en sus habitantes. Este art��culo investiga la constante oscilaci��n del artista entre adherirse y desestabilizar el conformismo y mecanizaci��n que atribu��a a los neoyorquinos. Yo sostengo que, a trav��s de sus intervenciones en el campo de la moda, Torres Garc��a gestion�� el potencial de los individuos urbanos para, ya sea, adherirse a los ritmos y estilos de vida impuestos por la ciudad, o resistir al jugar con los signos socio-econ��micos y la diversidad de identidades. Tambi��n muestro, que esta tensi��n sin resolver resuena en los escritos de Torres Garc��a correspondientes a esta ��poca, esclareciendo la relaci��n conflictiva del artista con la ciudad., Miradas - Revista de Historia del Arte y la Cultura de las Am��ricas y la Pen��nsula Ib��rica, Bd. 6 (2022): Miradas

IntroductionFollowing the detection of fetal growth restriction, there is no consensus about the criteria that should trigger delivery in the late preterm period. The consequences of inappropriate early or late delivery are potentially important yet practice varies widely around the world, with abnormal findings from fetal heart rate monitoring invariably leading to delivery. Indices derived from fetal cerebral Doppler examination may guide such decisions although there are few studies in this area. We propose a randomised, controlled trial to establish the optimum method of timing delivery between 32 weeks and 36 weeks 6 days of gestation. We hypothesise that delivery on evidence of cerebral blood flow redistribution reduces a composite of perinatal poor outcome, death and short-term hypoxia-related morbidity, with no worsening of neurodevelopmental outcome at 2 years.Methods and analysisWomen with non-anomalous singleton pregnancies 32+0 to 36+6 weeks of gestation in whom the estimated fetal weight or abdominal circumference is Ethics and disseminationThe Study Coordination Centre has obtained approval from London-Riverside Research Ethics Committee (REC) and Health Regulatory Authority (HRA). Publication will be in line with NIHR Open Access policy.Trial registration numberMain sponsor: Imperial College London, Reference: 19QC5491. Funders: NIHR HTA, Reference: 127 976. Study coordination centre: Imperial College Healthcare NHS Trust, Du Cane Road, London, W12 0HS with Centre for Trials Research, College of Biomedical & Life Sciences, Cardiff University. IRAS Project ID: 266 400. REC reference: 20/LO/0031. ISRCTN registry: 76 016 200.