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53 results on '"Fine DL"'

51. Simian tumour virus proliferation in inoculated Macaca mulatta.

Author

Fine DL, Kingsbury EW, Valerio MG, Kubicek MT, Landon JC, and Chopra HC

Subjects
Animals, Animals, Newborn, Female, Haplorhini, Hyperplasia, Lymph Nodes microbiology, Lymph Nodes pathology, Macaca, Microscopy, Electron, Oncogenic Viruses growth & development, RNA Viruses growth & development
Published
1972
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52. Development of herpes simplex virus in the isolated nuclei of HEp-2 cells. II. Intranuclear events in isolated HSV-infected nuclei.

Author

Fine DL and Ludwig EH

Subjects
Acridines, Animals, Antigens, Viral analysis, Arginine metabolism, Carcinoma, Cell Line metabolism, Cell Nucleus metabolism, Culture Media, Cytopathogenic Effect, Viral, DNA, Viral biosynthesis, Fluorescent Antibody Technique, Humans, Immune Sera, Laryngeal Neoplasms, Microscopy, Fluorescence, Microscopy, Phase-Contrast, Rabbits, Simplexvirus immunology, Simplexvirus metabolism, Staining and Labeling, Time Factors, Viral Proteins biosynthesis, Cell Line microbiology, Cell Nucleus microbiology, Simplexvirus growth & development
Published
1972
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53. Host-cell lysosomal response to two strains of herpes simplex virus.

Author

Fine DL, Lake RS, and Ludwig EH

Subjects
Acid Phosphatase metabolism, Acridines, Carcinoma pathology, Cell Line, Cytopathogenic Effect, Viral, Humans, Laryngeal Neoplasms pathology, Microscopy, Fluorescence, Microscopy, Phase-Contrast, Simplexvirus growth & development, Staining and Labeling, Culture Techniques, Lysosomes enzymology, Simplexvirus pathogenicity
Abstract

A correlation has been made between the host lysosomal responses to and release of infectious virus from HEp-2 cells infected with two strains of herpes simplex virus (HSV). Supravital staining with acridine orange was used for morphological studies of macroplaque and microplaque HSV-infected cells. With the progression of infection, cells infected with either microplaque HSV or macroplaque HSV were observed to undergo different lysosomal and cytopathic changes, which could be correlated with increased accumulation of acid phosphatase and infectious virus in the extracellular fluid.

Published
1970
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