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52. Electroencephalogram in the intensive care unit: a focused look at acute brain injury

Author

Alkhachroum, Ayham, Appavu, Brian, Egawa, Satoshi, Foreman, Brandon, Gaspard, Nicolas, Gilmore, Emily J., and Hirsch, Lawrence J.

Subjects
United States. National Institutes of Health, Injuries, Epilepsy, Electroencephalography, Seizures (Medicine), Brain injuries, Medical schools, Brain -- Injuries, Medical colleges
Abstract

Author(s): Ayham Alkhachroum [sup.1] [sup.2], Brian Appavu [sup.3] [sup.4], Satoshi Egawa [sup.5], Brandon Foreman [sup.6], Nicolas Gaspard [sup.7], Emily J. Gilmore [sup.8] [sup.9], Lawrence J. Hirsch [sup.8], Pedro Kurtz [sup.10] [...], Over the past decades, electroencephalography (EEG) has become a widely applied and highly sophisticated brain monitoring tool in a variety of intensive care unit (ICU) settings. The most common indication for EEG monitoring currently is the management of refractory status epilepticus. In addition, a number of studies have associated frequent seizures, including nonconvulsive status epilepticus (NCSE), with worsening secondary brain injury and with worse outcomes. With the widespread utilization of EEG (spot and continuous EEG), rhythmic and periodic patterns that do not fulfill strict seizure criteria have been identified, epidemiologically quantified, and linked to pathophysiological events across a wide spectrum of critical and acute illnesses, including acute brain injury. Increasingly, EEG is not just qualitatively described, but also quantitatively analyzed together with other modalities to generate innovative measurements with possible clinical relevance. In this review, we discuss the current knowledge and emerging applications of EEG in the ICU, including seizure detection, ischemia monitoring, detection of cortical spreading depolarizations, assessment of consciousness and prognostication. We also review some technical aspects and challenges of using EEG in the ICU including the logistics of setting up ICU EEG monitoring in resource-limited settings.

Published
2022
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53. Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study

Author

Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Bodien, Yelena, Bullock, M. Ross, Chesnut, Randall, Corrigan, John D., Crawford, Karen, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, V Ramana, Ferguson, Adam R., Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Giacino, Joseph, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, J Claude, Hotz, Gillian, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Nelson, Lindsay, Ngwenya, Laura, Palacios, Eva, Perl, Daniel, Rabinowitz, Miri, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Toga, Arthur, Valadka, Alex, Vassar, Mary, Vespa, Paul, Zafonte, Ross, Wang, Kevin K., Munoz-Pareja, Jennifer C., Lautenslager, Lauren A., Tyndall, J. Adrian, Yang, Zhihui, Kerrigan, Maria R., Diaz-Arrastia, Ramon, Korley, Frederick K., Okonkwo, David, Puccio, Ava M., Yue, John K., Taylor, Sabrina R., Mukherjee, Pratik, Yuh, Esther L., Temkin, Nancy R., Robertson, Claudia S., Sun, Xiaoying, Jain, Sonia, Markowitz, Amy J., and Manley, Geoffrey T.

Published
2023
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54. Which Spreading Depolarizations Are Deleterious To Brain Tissue?

Author

Shuttleworth, C William, Andrew, R David, Akbari, Yama, Ayata, Cenk, Balu, Ramani, Brennan, KC, Boutelle, Martyn, Carlson, Andrew P, Dreier, Jens P, Fabricius, Martin, Farkas, Eszter, Foreman, Brandon, Helbok, Raimund, Henninger, Nils, Jewell, Sharon L, Jones, Stephen C, Kirov, Sergei A, Lindquist, Britta E, Maciel, Carolina B, Okonkwo, David, Reinhart, Katelyn M, Robertson, R Meldrum, Rosenthal, Eric S, Watanabe, Tomas, and Hartings, Jed A

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Brain Disorders, Animals, Brain, Brain Injuries, Cortical Spreading Depression, Electroencephalography, Humans, Migraine with Aura, Spreading depression, Spreading depolarization, Ischemia, Trauma, Subarachnoid hemorrhage, Neurology & Neurosurgery, Clinical sciences, Nursing
Abstract

Spreading depolarizations (SDs) are profound disruptions of cellular homeostasis that slowly propagate through gray matter and present an extraordinary metabolic challenge to brain tissue. Recent work has shown that SDs occur commonly in human patients in the neurointensive care setting and have established a compelling case for their importance in the pathophysiology of acute brain injury. The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in September of 2018 included a discussion session focused on the question of "Which SDs are deleterious to brain tissue?" iCSD is attended by investigators studying various animal species including invertebrates, in vivo and in vitro preparations, diseases of acute brain injury and migraine, computational modeling, and clinical brain injury, among other topics. The discussion included general agreement on many key issues, but also revealed divergent views on some topics that are relevant to the design of clinical interventions targeting SDs. A draft summary of viewpoints offered was then written by a multidisciplinary writing group of iCSD members, based on a transcript of the session. Feedback of all discussants was then formally collated, reviewed and incorporated into the final document. It is hoped that this report will stimulate collection of data that are needed to develop a more nuanced understanding of SD in different pathophysiological states, as the field continues to move toward effective clinical interventions.

Published
2020

55. The Temporal Relationship of Mental Health Problems and Functional Limitations following mTBI: A TRACK-TBI and TED Study

Author

Zahniser, Evan, Nelson, Lindsay D, Dikmen, Sureyya S, Machamer, Joan E, Stein, Murray B, Yuh, Esther, Manley, Geoffrey T, Temkin, Nancy R, Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Bodien, Yelena, Ross Bullock, M, Chesnut, Randall, Corrigan, John D, Crawford, Karen, Diaz-Arrastia, Ramon, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, V Ramana, Ferguson, Adam, Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Giacino, Joseph, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Claude Hemphill, J, Hotz, Gillian, Jain, Sonia, Korley, Frederick, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Noel, Florence, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Sherer, Mark, Taylor, Sabrina, Toga, Arthur, Valadka, Alex, Vassar, Mary, Vespa, Paul, Wang, Kevin, Yue, John, and Zafonte, Ross

Subjects
Behavioral and Social Science, Depression, Mental Health, Biomedical Imaging, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Traumatic Head and Spine Injury, Neurosciences, Traumatic Brain Injury (TBI), Clinical Research, 6.6 Psychological and behavioural, Evaluation of treatments and therapeutic interventions, Mental health, Injuries and accidents, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Brain Concussion, Female, Humans, Longitudinal Studies, Male, Middle Aged, Recovery of Function, Time Factors, Young Adult, brain injuries, mental health, patient outcome assessment, traumatic, TRACK-TBI Investigators, Clinical Sciences, Neurology & Neurosurgery
Abstract

Mental health problems, such as depression and anxiety, are often associated with functional limitations after traumatic brain injury (TBI), prompting researchers to explore which of these TBI-related sequelae tends to precede the other. Past studies among patients with injuries ranging in severity have predominantly reported that functional impairments predict subsequent psychological concerns, rather than the other way around; however, it remains unclear whether this directionality holds for individuals with mild TBI (mTBI). The present study utilized a cross-lagged panel design within a structural equation modeling analytical framework to explore the longitudinal relationships of symptoms of depression and anxiety to functional status among 717 adult mTBI patients, with assessments occurring at 2 weeks and 3 months post-injury. Symptoms of both depression and anxiety significantly predicted subsequent functional limitations (λs = -0.21 and -0.25), whereas the reverse effects were nonsignificant (λs = -0.05 and -0.03); thus, psychological concerns appeared to function as a precursor to functional impairment. This pattern was particularly pronounced among patients with normal head computed tomography (CT) results; however, results were less clear cut among those subjects whose injuries were accompanied by intracranial abnormalities detected on CT imaging, suggesting the possibility of a more reciprocal relationship in the case of CT-positive mTBI. These results may serve to partially explain the incidence of persistent functional limitations observed among subsets of mTBI patients in past studies. Findings likewise highlight the importance of assessment and treatment for mental health problems after mTBI as an important factor to promote psychological well-being and functional recovery.

Published
2019

56. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Author

Vespa, Paul M, Shrestha, Vikesh, Abend, Nicholas, Agoston, Denes, Au, Alicia, Bell, Michael J, Bleck, Thomas P, Blanco, Manuel Buitrago, Claassen, Jan, Diaz-Arrastia, Ramon, Duncan, Dominique, Ellingson, Ben, Foreman, Brandon, Gilmore, Emily J, Hirsch, Lawrence, Hunn, Martin, Kamnaksh, Alaa, McArthur, David, Morokoff, Andrew, O'Brien, Terrence, O'Phelan, Kristine, Robertson, Courtney L, Rosenthal, Eric, Staba, Richard, Toga, Arthur, Willyerd, Frederick A, Zimmermann, Lara, Yam, Elisa, Martinez, Susana, Real, Courtney, and Engel, Jerome

Subjects
Biomedical and Clinical Sciences, Neurosciences, Brain Disorders, Epilepsy, Neurodegenerative, Traumatic Head and Spine Injury, Traumatic Brain Injury (TBI), Physical Injury - Accidents and Adverse Effects, Precision Medicine, Clinical Research, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Good Health and Well Being, Biomarkers, Brain, Brain Injuries, Traumatic, Computational Biology, Epilepsy, Post-Traumatic, Humans, Longitudinal Studies, Observational Studies as Topic, Prospective Studies, Clinical Sciences, Neurology & Neurosurgery, Biochemistry and cell biology
Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

Published
2019

57. Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study

Author

Adeoye, Opeolu, Badatjia, Neeraj, Duhaime, Ann-Christine, Ferguson, Adam, Foreman, Brandon, Giacino, Joseph T, Gopinath, Shankar, Grandhi, Ramesh, Kitagawa, Ryan, Madden, Christopher, Merchant, Randall, McCrea, Mike, Ngwenya, Laura, Rabinowitz, Miri, Robertson, Claudia, Schnyer, David, Stein, Murray, Vassar, Mary, Wang, Vincent, Valadka, Alex, Zafonte, Ross, Korley, Frederick K, Jain, Sonia, Sun, Xiaoying, Puccio, Ava M, Yue, John K, Gardner, Raquel C, Wang, Kevin K W, Okonkwo, David O, Yuh, Esther L, Mukherjee, Pratik, Nelson, Lindsay D, Taylor, Sabrina R, Markowitz, Amy J, Diaz-Arrastia, Ramon, and Manley, Geoffrey T

Published
2022
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62. Commentary on stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges.

Author

Ng, Marcus C., Zafar, Sahar, Foreman, Brandon, Kim, Jennifer, Struck, Aaron F., and Westover, M. Brandon

Subjects
ELECTROENCEPHALOGRAPHY, TREATMENT effectiveness, BRAIN diseases, ETIOLOGY of diseases, DRUGS
Abstract

Here we critique recent arguments proposing to distinguish ictal from non‐ictal generalized periodic discharges (GPDs) based on etiology and stimulation response, arguing that these are unreliable. We advocate for an empirical approach to GPDs: describe objectively, interpret through medication trials, and base further treatment on response. We call for evidence‐based approaches considering meaningful clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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63. A genome-wide association study of outcome from traumatic brain injury

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark, Coles, Jonathan P., Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, DahyotFizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Corte, Francesco Della, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, GuyLoup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J.A., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Jiyao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, LarsOwe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., CastañoLeón, Ana M., Maegele, Marc, Majdan, Marek, Manara, Alex, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David K., Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia F.J., Nieboer, Daan, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, JeanFrançois, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, SanchezPorras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, van der Jagt, Mathieu, van der Steen, Gregory, van der Naalt, Joukje, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, Vyvere, Thijs Vande, van Wijk, Roel P.J., Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, Zoerle, Tommaso, Izzy, Saef, Radmanesh, Farid, Frantzén, Janek, Katila, Ari, Maanpää, Henna-Rikka, Tallus, Jussi, Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Barber, Jason, Bodien, Yelena, Chesnut, Randall, Corrigan, John D., Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, Ramana, Ferguson, Adam R., Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Giacino, Joseph, Goldman, Dana, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, Claude, Hotz, Gillian, Jain, Sonia, Keene, Dirk, Korley, Frederick K., Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Manley, Geoffrey T., Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B, Noel, Florence, Nolan, Amber, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Sherer, Mark, Stein, Murray, Taylor, Sabrina, Temkin, Nancy, Toga, Arthur, Valadka, Alex, Vassar, Mary, Yue, John K., Yuh, Esther, Zafonte, Ross, Kals, Mart, Kunzmann, Kevin, Parodi, Livia, Anderson, Christopher D., Puccio, Ava M., Okonkwo, David O., Stein, Murray B., and Manley, Geoff T.

Published
2022
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64. Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation

Author

Ackerlund, Cecilia, Adams, Hadie, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Carbayo Lozano, Guillermo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Covic, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, den Boogert, Hugo, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Manara, Alex, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McFadyen, Charles, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Retel Helmrich, Isabel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Te Ao, Braden, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Erp, Inge A., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, van Wijk, Roel, Vande Vyvere, Thijs, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Peter, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, Adeoye, Opeolu, Badjatia, Neeraj, Barber, Jason, Bergin, Michael, Boase, Kim, Bodien, Yelena, Chesnut, Randall, Corrigan, John, Crawford, Karen, Diaz-Arrastia, Ramon, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, Venkata, Ferguson, Adam R, Foreman, Brandon, Gaudette, Etienne, Giacino, Joseph, Gonzalez, Luis, Gopinath, Shankar, Grandhi, Ramesh, Gullapalli, Rao, Hemphill, Claude, Hotz, Gillian, Huie, Russell, Jha, Ruchira, Keene, C. Dirk, Kitagawa, Ryan, Korley, Frederick, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Mukherjee, Pratik, Nelson, Lindsay, Ngwenya, Laura B., Noel, Florence, Nolan, Amber, Okonkwo, David, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rodgers, Richard Ben, Rosand, Jonathan, Rosenthal, Eric, Sander, Angelle, Sandsmark, Danielle, Sugar, Gabriella, Schneider, Andrea, Schnyer, David, Seabury, Seth, Sherer, Mark, Stein, Murray, Temkin, Nancy, Toga, Arthur, Torres-Espin, Abel, Valadka, Alex, Vassar, Mary, Wang, Kevin, Wang, Vincent, Yue, John K., Yuh, Esther, Zafonte, Ross, Galimberti, Stefania, Graziano, Francesca, Maas, Andrew I R, Isernia, Giulia, Lecky, Fiona, Jain, Sonia, Sun, Xiaoying, Gardner, Raquel C, Taylor, Sabrina R, Markowitz, Amy J, Manley, Geoffrey T, Valsecchi, Maria Grazia, Bellelli, Giuseppe, and Citerio, Giuseppe

Published
2022
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65. Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis

Author

Hanin, Aurelie, primary, Jimenez, Anthony D., additional, Gopaul, Margaret, additional, Asbell, Hannah, additional, Aydemir, Seyhmus, additional, Basha, Maysaa Merhi, additional, Batra, Ayush, additional, Damien, Charlotte, additional, Day, Gregory S., additional, Eka, Onome, additional, Eschbach, Krista, additional, Fatima, Safoora, additional, Fields, Madeline C., additional, Foreman, Brandon, additional, Gerard, Elizabeth E., additional, Gofton, Teneille E., additional, Haider, Hiba A., additional, Hantus, Stephen T., additional, Hocker, Sara, additional, Jongeling, Amy, additional, Kalkach Aparicio, Mariel, additional, Kandula, Padmaja, additional, Kang, Peter, additional, Kazazian, Karnig, additional, Kellogg, Marissa A., additional, Kim, Minjee, additional, Lee, Jong Woo, additional, Marcuse, Lara V., additional, McGraw, Christopher M., additional, Mohamed, Wazim, additional, Orozco, Janet, additional, Pimentel, Cederic M., additional, Punia, Vineet, additional, Ramirez, Alexandra M., additional, Steriade, Claude, additional, Struck, Aaron F., additional, Taraschenko, Olga, additional, Treister, Andrew K., additional, Wainwright, Mark S., additional, Yoo, Ji Yeoun, additional, Zafar, Sahar, additional, Zhou, Daniel J., additional, Zutshi, Deepti, additional, Gaspard, Nicolas, additional, and Hirsch, Lawrence J., additional

Published
2024
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70. Smaller Regional Brain Volumes Predict Posttraumatic Stress Disorder at 3 Months After Mild Traumatic Brain Injury

Author

Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Barber, Jason, Bodien, Yelena, Bullock, M. Ross, Chesnut, Randall, Corrigan, John D., Crawford, Karen, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, V. Ramana, Ferguson, Adam R., Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Goldman, Dana, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, J. Claude, Hotz, Gillian, Jain, Sonia, Keene, C. Dirk, Korley, Frederick K., Kramer, Joel, Kreitzer, Natalie, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, Merchant, Randall, Ngwenya, Laura B., Noel, Florence, Nolan, Amber, Palacios, Eva, Perl, Daniel, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Toga, Arthur, Valadka, Alex, Vespa, Paul, Wang, Kevin, Yue, John K., Zafonte, Ross, Stein, Murray B., Yuh, Esther, Okonkwo, David O., Mac Donald, Christine L., Levin, Harvey, Giacino, Joseph T., Dikmen, Sureyya, Vassar, Mary J., Diaz-Arrastia, Ramon, Robertson, Claudia S., Nelson, Lindsay D., McCrea, Michael, Sun, Xiaoying, Temkin, Nancy, Taylor, Sabrina R., Markowitz, Amy J., Manley, Geoffrey T., and Mukherjee, Pratik

Published
2021
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72. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial

Author

Gray, Emily, Gunter, Sonya, Fansler, Amy, Stevenson, Valerie, Bengelink, Erin, Harney, Deneil, Speers, Mickie, Black, Joy, Fisher, Natalie, Harsh, Donna, Ramakrishnan, Arthi, Harris, Lindsey, Bozeman, Nia, Spiteri, Aimee, Palesch, Yuko, Tillman, Holly, Zhao, Wenle, Pauls, Qi, Arnaud, Chris, Dillon, Catherine R., Riley, Jodie, Alford, Teldon, Conner, Cassidy, Coles, Lisa, Sathe, Abhi, Janis, Scott, Hartman, Adam, Fureman, Brandy, Trinka, Eugen, Treiman, David, Wright, David, Ratcliff, Jonathan, Hall, Alex, Williams, Alaina, Simon, Harold, Stanley, Nicholas, Humphries, Roger, Mims, Theresa, Short, Joann, Jones, Elizabeth, Ottman, Misty, Gentile, Nina, Isenberg, Derek, Reimer, Hannah, Sayoc Kalugdan, Vernon, Hemphill, Claude, Yi Madhok, Debbie, Duncan, Jeany, Randazzo, Dominica, Quinn, James, Visweswaran, Anita, Mann, Rosen, Adeoye, Opeolu, McMullan, Jason, Foreman, Brandon, Keegan, Sara, Biros, Michelle, Driver, Brian, Hendrickson, Audrey, Stang, Jamie, Lewandowski, Christopher, Miller, Joseph, Chaudhry, Kaleem, Berry, Shannen, Warden, Craig, Blake, Rachel, Cook, Jennifer NB, Sabolick, Erin, Selman, Antoine, Kissman, Katrina, Moore, Monica, Huff, J. Stephen, Becker, Lea, Claassen, Jan, Velazquez, Angela, Falo, Cristina, Coralic, Zlatan, Grupp-Phelan, Jackie, Baren, Jill, Ellison, Angela, Woodford, Ashley, Samba, Ima, Kittick, Marlena, Riviello, Ralph, Massey, John, Bonacquisti, Lisa, Levine, Steven, Motov, Sergey, Fromm, Christian, Hossain, Rukhsana, Likourezos, Antonios, Pushkar, Illya, Terndrup, Thomas, Khaliqdina, Salman, Hill, Michael, Peterson, Bjorn, Terwilliger, Alexia, Holm, Joseph, Wicklund, Kyra, Wewerka, Sandi, Welch, Robert, Pearson, Claire, Kumar, Vijaya Arun, Ayaz, Farhan, Bhuiyan, Saikat, Mika, Valerie H., Morgan, Lola, Jones, Floyd, Dishman, Lorraine, Henry, Thomas, Erickson, Ford, Staugaitis, Abbey, Lawyer, Chloe, Miller, Kathleen, Callaway, Clif, Urban, Alexandra, DiFiore, Sara, Adams, Peter, Baum, Brian, Nomura, Jason, Davis, Barbara, Aufderheide, Tom, Emmrich, Amanda, Mena, Melissa, Labinski, Jacob, Ogedegbe, Chinwe, McCarthy, Diana, Villot-Santiago, Arelis, Goldstein, Joshua, Rosenthal, Eric S., Cohen, Abigail, Mei Su, Chen, Tirrell, Greg, Howell, Melissa, Hendrickson, Marissa, Nerheim, Dan, Jaton, Eric, Biney, Barbara, Gibson, Christopher, Dahlmeier, Erica, Blackburn, Katherine (Lamond), Vaughan-Ogunlusi, Oluwarotimi (Tim), Zehtabchi, Shahriar, Sinert, Richard, Petty, Bryce, Youngquist, Scott, Carlson, Margaret, Gilles, Nadege, Weingast, Sarah (Zelonis), Stern, Barney, Hopp, Jennifer, Ganley, Virginia, Ornato, Joseph, Hogan, Christopher, Payne, Alan, Shreve, Kate, Dayan, Peter, Kuppermann, Nathan, Denninghoff, Kurt, Stanley, Rachel, Ruddy, Richard, Lerner, E. Brooke, Dean, J. Michael, Casper, Charles, Nigrovic, Lise, Schalick, Walt, Nelson, Doug, Thomas, Bobbe, Okada, Pamela, Lee, Amanda, Truesdale, Natasha, Chan, Steven, Naresh, Mhadhumithaa, Robinson, Venita, Hwang, Jieun, Carlston, Kristi, Dela Cruz, Michael, Harbour, Toni, Karki, Reena, Cohen, Daniel M., Nowakowski, Amy, Lin, Cindy, Fisher Kenny, Erin, Steele, Dale, Merck, Lisa H., Ryan, Erin, Basso, Kristin, D'Urso, Lesley (Wasilewski), Brown, Kathleen, Nauman, Gina, Ledda, Matthew, Gillen, Sean, Grant, Vanessa, Vance, Cheryl, Nishijima, Daniel K., Pimenta, Kyle, Herzog, Noelle, Bennett, Jonathan, Eisenhart, Christine, Thomas, Danny, Wagner, Duke, Hickey, Robert W., Azrak, Rose, Rubalcava, Daniel, Mondragon, Juan, Gonzalez, Victor, Khalil, Maha, Hart, Kristina, Parker, Sara, Lumba-Brown, Angela, Quayle, Kim, Chinta, Sri, Robinson, Debra, Kwok, Maria, Peery, Brooke, Ochs, Julie, Suarez, Leonor, Chamberlain, James M, Kapur, Jaideep, Shinnar, Shlomo, Elm, Jordan, Holsti, Maija, Babcock, Lynn, Rogers, Alex, Barsan, William, Cloyd, James, Lowenstein, Daniel, Bleck, Thomas P, Conwit, Robin, Meinzer, Caitlyn, Cock, Hannah, Fountain, Nathan B, Underwood, Ellen, Connor, Jason T, and Silbergleit, Robert

Published
2020
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74. Comparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis

Author

Jimenez, Anthony D., primary, Gopaul, Margaret, additional, Asbell, Hannah, additional, Aydemir, Seyhmus, additional, Basha, Maysaa M., additional, Batra, Ayush, additional, Damien, Charlotte, additional, Day, Gregory S., additional, Eka, Onome, additional, Eschbach, Krista, additional, Fatima, Safoora, additional, Fields, Madeline C., additional, Foreman, Brandon, additional, Gerard, Elizabeth E., additional, Gofton, Teneille E., additional, Haider, Hiba A., additional, Hantus, Stephen T., additional, Hocker, Sara, additional, Jongeling, Amy, additional, Kalkach Aparicio, Mariel, additional, Kandula, Padmaja, additional, Kang, Peter, additional, Kazazian, Karnig, additional, Kellogg, Marissa A., additional, Kim, Minjee, additional, Lee, Jong Woo, additional, Marcuse, Lara V., additional, McGraw, Christopher M., additional, Mohamed, Wazim, additional, Orozco, Janet, additional, Pimentel, Cederic, additional, Punia, Vineet, additional, Ramirez, Alexandra M., additional, Steriade, Claude, additional, Struck, Aaron F., additional, Taraschenko, Olga, additional, Treister, Andrew K., additional, Yoo, Ji Yeoun, additional, Zafar, Sahar, additional, Zhou, Daniel J., additional, Zutshi, Deepti, additional, Gaspard, Nicolas, additional, Hirsch, Lawrence J., additional, and Hanin, Aurelie, additional

Published
2024
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75. Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study

Author

Yue, John K., primary, Lee, Young M., additional, Sun, Xiaoying, additional, van Essen, Thomas A., additional, Elguindy, Mahmoud M., additional, Belton, Patrick J., additional, Pisică, Dana, additional, Mikolic, Ana, additional, Deng, Hansen, additional, Kanter, John H., additional, McCrea, Michael A., additional, Bodien, Yelena G., additional, Satris, Gabriela G., additional, Wong, Justin C., additional, Ambati, Vardhaan S., additional, Grandhi, Ramesh, additional, Puccio, Ava M., additional, Mukherjee, Pratik, additional, Valadka, Alex B., additional, Tarapore, Phiroz E., additional, Huang, Michael C., additional, DiGiorgio, Anthony M., additional, Markowitz, Amy J., additional, Yuh, Esther L., additional, Okonkwo, David O., additional, Steyerberg, Ewout W., additional, Lingsma, Hester F., additional, Menon, David K., additional, Maas, Andrew I. R., additional, Jain, Sonia, additional, Manley, Geoffrey T., additional, _, _, additional, Badjatia, Neeraj, additional, Barber, Jason, additional, Chesnut, Randall M., additional, Diaz-Arrastia, Ramon, additional, Duhaime, Ann-Christine, additional, Eagle, Shawn R., additional, Etemad, Leila L., additional, Fabian, Brian, additional, Ferguson, Adam R., additional, Foreman, Brandon, additional, Gardner, Raquel C., additional, Giacino, Joseph T., additional, Gopinath, Shankar, additional, Gotthardt, Christine J., additional, Hamidi, Sabah, additional, Huie, J. Russell, additional, Keene, C. Dirk, additional, Korley, Frederick K., additional, Madhok, Debbie Y., additional, Madden, Christopher, additional, Merchant, Randall, additional, Nelson, Lindsay D., additional, Ngwenya, Laura B., additional, Robertson, Claudia S., additional, Rodgers, Richard B, additional, Schneider, Andrea L. C., additional, Schnyer, David M., additional, Stein, Murray B., additional, Taylor, Sabrina R., additional, Temkin, Nancy R., additional, Torres-Espin, Abel, additional, Tracey, Joye X., additional, Vassar, Mary J., additional, Wang, Kevin K. W., additional, and Zafonte, Ross D., additional

Published
2024
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76. Correction to: Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

Author

Mainali, Shraddha, Aiyagari, Venkatesh, Alexander, Sheila, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Brown, Emery, Brown, Jeremy, Claassen, Jan, Edlow, Brian L., Fink, Ericka L., Fins, Joseph J., Foreman, Brandon, Frontera, Jennifer, Geocadin, Romergryko G., Giacino, Joseph, Gilmore, Emily J., Gosseries, Olivia, Hammond, Flora, Helbok, Raimund, Claude Hemphill, J., Hirsch, Karen, Kim, Keri, Laureys, Steven, Lewis, Ariane, Ling, Geoffrey, Livesay, Sarah L., McCredie, Victoria, McNett, Molly, Menon, David, Molteni, Erika, Olson, DaiWai, O’Phelan, Kristine, Park, Soojin, Polizzotto, Len, Javier Provencio, Jose, Puybasset, Louis, Venkatasubba Rao, Chethan P., Robertson, Courtney, Rohaut, Benjamin, Rubin, Michael, Sharshar, Tarek, Shutter, Lori, Sampaio Silva, Gisele, Smith, Wade, Stevens, Robert D., Thibaut, Aurore, Vespa, Paul, Wagner, Amy K., Ziai, Wendy C., Zink, Elizabeth, and Suarez, Jose I.

Published
2022
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77. Improving the food insecurity screening rate at one outpatient ambulatory care center: a quality improvement project

Author

O'Malley, Evan, Foreman, Brandon, Adelman, Megan, and Crawford, Leah

Subjects
Management, Evaluation, Methods, Company business management, Health screening -- Methods, Ambulatory care facilities -- Management, Food supply -- Evaluation, Clinics -- Management, Medical screening -- Methods
Abstract

Presenters Evan O'Malley, DO, Brandon Foreman, DO, Megan Adelman, PharmD, Leah Crawford, [...], Food Insecurity is defined as not having consistent, meaningful access to enough food for both an active and healthy lifestyle. It is a social determinant of health that significantly impacts a multitude of health outcomes, including hypertension, diabetes, and mental health. Estimates indicate food insecurity affects approximately 10.5% of households in America, which has only been exacerbated by the COVID19 pandemic. The scope of this project was to better understand the prevalence in our population while creating a new workflow process to provide vital resources to patients who had a positive screening. The aim of this project was to increase the number of patients being screened for food insecurity from 0 to 5 total per week from April 1, 2021 to December 31, 2021 through the use of a paper screening. The validated two-question food insecurity screening tool that is present in the institution's electronic medical record (EMR) was made into a paper survey and distributed at intake. These screenings would be collected by the nursing staff and inputted into the chart. Positive screenings would be addressed by the provider who provided resources and/or a social work consult. We utilized a data collection system that tracked the deidentified total number of responses and each individual answer. A random sampling of 22 paper screenings were selected for in-depth review to determine how the positive screening was addressed. In total, we had 787 survey responses with 220 (27.9%) positive screenings for food insecurity. The total amount of screenings each month varied considerably. Based on our random sampling of 22 patients who had a positive screening, 6 (27.3%) had documentation of a discussion on food insecurity in the EMR and 2 (9.1%) had a referral made to social work. Our project demonstrated that a validated paper screening can increase the identification, documentation, and education of food insecurity significantly. The responses we received indicated that food insecurity rates are much higher than previously understood in other results and warrant further work to improve routine screening and to address the fundamental need in our communities.

Published
2023

79. Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Outcomes and Endpoints

Author

Bodien, Y, Larovere, K, Kondziella, D, Taran, S, Estraneo, A, Shutter, L, Null, N, Aiyagari, V, Akbari, Y, Al-Mufti, F, Alexander, S, Alexandrov, A, Alkhachroum, A, Amiri, M, Appavu, B, Gebre, M, Bader, M, Badjiata, N, Balu, R, Barra, M, Beekman, R, Beghi, E, Bell, K, Beqiri, E, Berlin, T, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brown, E, Caceres, E, Carroll, E, Cediel, E, Chou, S, Citerio, G, Claassen, J, Condie, C, Cosmas, K, Creutzfeldt, C, Dangayach, N, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Diringer, M, Dullaway, J, Edlow, B, Ercole, A, Falcone, G, Farrokh, S, Ferioli, S, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Frontera, J, Ganesan, R, Ghavam, A, Giacino, J, Gibbons, C, Gilmore, E, Gosseries, O, Green, T, Greer, D, Guanci, M, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Jones, M, Keller, E, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lawson, T, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Madden, L, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Massimini, M, Mayer, S, Mccredie, V, Mcnett, M, Mejia-Mantilla, J, Menon, D, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Molteni, E, Monti, M, Morrison, C, Muehlschlegel, S, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Natarajan, G, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Park, S, Pergakis, M, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puybasset, L, Rao, C, Rasmussen, L, Rass, V, Reznik, M, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Rosanova, M, Rosenthal, E, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosen, A, Shapshak, A, Sharma, K, Sharshar, T, Sitt, J, Slomine, B, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sussman, B, Thibaut, A, Threlkeld, Z, Tinti, L, Toker, D, Torbey, M, Trevick, S, Turgeon, A, Udy, A, Varelas, P, Vespa, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wainwright, M, Whyte, J, Witherspoon, B, Yakhind, A, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Bodien, Yelena G., LaRovere, Kerri, Kondziella, Daniel, Taran, Shaurya, Estraneo, Anna, Shutter, Lori, null, null, Aiyagari, Venkatesh, Akbari, Yama, Al-Mufti, Fawaz, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Amiri, Moshagan, Appavu, Brian, Gebre, Meron Awraris, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Bell, Kathleen, Beqiri, Erta, Berlin, Tracey, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brown, Emery, Caceres, Eder, Carroll, Elizabeth, Cediel, Emilio, Chou, Sherry, Citerio, Giuseppe, Claassen, Jan, Condie, Chad, Cosmas, Katie, Creutzfeldt, Claire, Dangayach, Neha, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Diringer, Michael, Dullaway, James, Edlow, Brian, Ercole, Ari, Falcone, Guido, Farrokh, Salia, Ferioli, Simona, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Frontera, Jennifer, Ganesan, Rishi, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Hinson, H. E., Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L., Janas, Anna, Jones, Morgan, Keller, Emanuela, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matt, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lawson, Thomas, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, Madden, Lori, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Massimini, Marcello, Mayer, Stephan, McCredie, Victoria, McNett, Molly, Mejia-Mantilla, Jorge, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Molteni, Erika, Monti, Martin, Morrison, Chris, Muehlschlegel, Susanne, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Natarajan, Girija, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Park, Soojin, Pergakis, Melissa, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rass, Verena, Reznik, Michael, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Rosanova, Mario, Rosenthal, Eric, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank, Shapiro-Rosen, Amy, Shapshak, Angela, Sharma, Kartavya, Sharshar, Tarek, Sitt, Jacobo, Slomine, Beth, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sussman, Bethany, Thibaut, Aurore, Threlkeld, Zachary, Tinti, Lorenzo, Toker, Daniel, Torbey, Michel, Trevick, Stephen, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhind, Aleksandra, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, Zink, Elizabeth, Bodien, Y, Larovere, K, Kondziella, D, Taran, S, Estraneo, A, Shutter, L, Null, N, Aiyagari, V, Akbari, Y, Al-Mufti, F, Alexander, S, Alexandrov, A, Alkhachroum, A, Amiri, M, Appavu, B, Gebre, M, Bader, M, Badjiata, N, Balu, R, Barra, M, Beekman, R, Beghi, E, Bell, K, Beqiri, E, Berlin, T, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brown, E, Caceres, E, Carroll, E, Cediel, E, Chou, S, Citerio, G, Claassen, J, Condie, C, Cosmas, K, Creutzfeldt, C, Dangayach, N, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Diringer, M, Dullaway, J, Edlow, B, Ercole, A, Falcone, G, Farrokh, S, Ferioli, S, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Frontera, J, Ganesan, R, Ghavam, A, Giacino, J, Gibbons, C, Gilmore, E, Gosseries, O, Green, T, Greer, D, Guanci, M, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Jones, M, Keller, E, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lawson, T, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Madden, L, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Massimini, M, Mayer, S, Mccredie, V, Mcnett, M, Mejia-Mantilla, J, Menon, D, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Molteni, E, Monti, M, Morrison, C, Muehlschlegel, S, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Natarajan, G, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Park, S, Pergakis, M, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puybasset, L, Rao, C, Rasmussen, L, Rass, V, Reznik, M, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Rosanova, M, Rosenthal, E, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosen, A, Shapshak, A, Sharma, K, Sharshar, T, Sitt, J, Slomine, B, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sussman, B, Thibaut, A, Threlkeld, Z, Tinti, L, Toker, D, Torbey, M, Trevick, S, Turgeon, A, Udy, A, Varelas, P, Vespa, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wainwright, M, Whyte, J, Witherspoon, B, Yakhind, A, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Bodien, Yelena G., LaRovere, Kerri, Kondziella, Daniel, Taran, Shaurya, Estraneo, Anna, Shutter, Lori, null, null, Aiyagari, Venkatesh, Akbari, Yama, Al-Mufti, Fawaz, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Amiri, Moshagan, Appavu, Brian, Gebre, Meron Awraris, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Bell, Kathleen, Beqiri, Erta, Berlin, Tracey, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brown, Emery, Caceres, Eder, Carroll, Elizabeth, Cediel, Emilio, Chou, Sherry, Citerio, Giuseppe, Claassen, Jan, Condie, Chad, Cosmas, Katie, Creutzfeldt, Claire, Dangayach, Neha, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Diringer, Michael, Dullaway, James, Edlow, Brian, Ercole, Ari, Falcone, Guido, Farrokh, Salia, Ferioli, Simona, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Frontera, Jennifer, Ganesan, Rishi, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Hinson, H. E., Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L., Janas, Anna, Jones, Morgan, Keller, Emanuela, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matt, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lawson, Thomas, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, Madden, Lori, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Massimini, Marcello, Mayer, Stephan, McCredie, Victoria, McNett, Molly, Mejia-Mantilla, Jorge, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Molteni, Erika, Monti, Martin, Morrison, Chris, Muehlschlegel, Susanne, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Natarajan, Girija, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Park, Soojin, Pergakis, Melissa, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rass, Verena, Reznik, Michael, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Rosanova, Mario, Rosenthal, Eric, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank, Shapiro-Rosen, Amy, Shapshak, Angela, Sharma, Kartavya, Sharshar, Tarek, Sitt, Jacobo, Slomine, Beth, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sussman, Bethany, Thibaut, Aurore, Threlkeld, Zachary, Tinti, Lorenzo, Toker, Daniel, Torbey, Michel, Trevick, Stephen, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhind, Aleksandra, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, and Zink, Elizabeth

Abstract

Background: Clinical management of persons with disorders of consciousness (DoC) is dedicated largely to optimizing recovery. However, selecting a measure to evaluate the extent of recovery is challenging because few measures are designed to precisely assess the full range of potential outcomes, from prolonged DoC to return of preinjury functioning. Measures that are designed specifically to assess persons with DoC are often performance-based and only validated for in-person use. Moreover, there are no published recommendations addressing which outcome measures should be used to evaluate DoC recovery. The resulting inconsistency in the measures selected by individual investigators to assess outcome prevents comparison of results across DoC studies. The National Institute of Neurological Disorders and Stroke (NINDS) common data elements (CDEs) is an amalgamation of standardized variables and tools that are recommended for use in studies of neurologic diseases and injuries. The Neurocritical Care Society Curing Coma Campaign launched an initiative to develop CDEs specifically for DoC and invited our group to recommend CDE outcomes and endpoints for persons with DoCs. Methods: The Curing Coma Campaign Outcomes and Endpoints CDE Workgroup, consisting of experts in adult and pediatric neurocritical care, neurology, and neuroscience, used a previously established five-step process to identify and select candidate CDEs: (1) review of existing NINDS CDEs, (2) nomination and systematic vetting of new CDEs, (3) CDE classification, (4) iterative review and approval of panel recommendations, and (5) development of case report forms. Results: Among hundreds of existing NINDS outcome and endpoint CDE measures, we identified 20 for adults and 18 for children that can be used to assess the full range of recovery from coma. We also proposed 14 new outcome and endpoint CDE measures for adults and 5 for children. Conclusions: The DoC outcome and endpoint CDEs are a starting point in t

Published
2024

80. Clinical profile of patients with acute traumatic brain injury undergoing cranial surgery in the United States:report from the 18-centre TRACK-TBI cohort study

Author

Yue, John K., Kanter, John H., Barber, Jason K., Huang, Michael C., van Essen, Thomas A., Elguindy, Mahmoud M., Foreman, Brandon, Korley, Frederick K., Belton, Patrick J., Pisică, Dana, Lee, Young M., Kitagawa, Ryan S., Vassar, Mary J., Sun, Xiaoying, Satris, Gabriela G., Wong, Justin C., Ferguson, Adam R., Huie, J. Russell, Wang, Kevin K.W., Deng, Hansen, Wang, Vincent Y., Bodien, Yelena G., Taylor, Sabrina R., Madhok, Debbie Y., McCrea, Michael A., Ngwenya, Laura B., DiGiorgio, Anthony M., Tarapore, Phiroz E., Stein, Murray B., Puccio, Ava M., Giacino, Joseph T., Diaz-Arrastia, Ramon, Lingsma, Hester F., Mukherjee, Pratik, Yuh, Esther L., Robertson, Claudia S., Menon, David K., Maas, Andrew I.R., Markowitz, Amy J., Jain, Sonia, Okonkwo, David O., Temkin, Nancy R., Manley, Geoffrey T., Yue, John K., Kanter, John H., Barber, Jason K., Huang, Michael C., van Essen, Thomas A., Elguindy, Mahmoud M., Foreman, Brandon, Korley, Frederick K., Belton, Patrick J., Pisică, Dana, Lee, Young M., Kitagawa, Ryan S., Vassar, Mary J., Sun, Xiaoying, Satris, Gabriela G., Wong, Justin C., Ferguson, Adam R., Huie, J. Russell, Wang, Kevin K.W., Deng, Hansen, Wang, Vincent Y., Bodien, Yelena G., Taylor, Sabrina R., Madhok, Debbie Y., McCrea, Michael A., Ngwenya, Laura B., DiGiorgio, Anthony M., Tarapore, Phiroz E., Stein, Murray B., Puccio, Ava M., Giacino, Joseph T., Diaz-Arrastia, Ramon, Lingsma, Hester F., Mukherjee, Pratik, Yuh, Esther L., Robertson, Claudia S., Menon, David K., Maas, Andrew I.R., Markowitz, Amy J., Jain, Sonia, Okonkwo, David O., Temkin, Nancy R., and Manley, Geoffrey T.

Abstract

Background: Contemporary surgical practices for traumatic brain injury (TBI) remain unclear. We describe the clinical profile of an 18-centre US TBI cohort with cranial surgery. Methods: The prospective, observational Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study (2014–2018; ClinicalTrials.gov #NCT02119182) enrolled subjects who presented to trauma centre and received head computed tomography within 24-h (h) post-TBI. We performed a secondary data analysis in subjects aged ≥17-years with hospitalisation. Clinical characteristics, surgery type/timing, hospital and six-month outcomes were reported. Findings: Of 2032 subjects (age: mean = 41.4-years, range = 17–89-years; male = 71% female = 29%), 260 underwent cranial surgery, comprising 65% decompressive craniectomy, 23% craniotomy, 12% other surgery. Subjects with surgery (vs. without surgery) presented with worse neurological injury (median Glasgow Coma Scale = 6 vs. 15; midline shift ≥5 mm: 48% vs. 2%; cisternal effacement: 61% vs. 4%; p < 0.0001). Median time-to-craniectomy/craniotomy was 1.8 h (interquartile range = 1.1–5.0 h), and 67% underwent intracranial pressure monitoring. Seventy-three percent of subjects with decompressive craniectomy and 58% of subjects with craniotomy had ≥3 intracranial lesion types. Decompressive craniectomy (vs. craniotomy) was associated with intracranial injury severity (median Rotterdam Score = 4 vs. 3, p < 0.0001), intensive care length of stay (median = 13 vs. 4-days, p = 0.0002), and six-month unfavourable outcome (62% vs. 30%; p = 0.0001). Earlier time-to-craniectomy was associated with intracranial injury severity. Interpretation: In a large representative cohort of patients hospitalised with TBI, surgical decision-making and time-to-surgery aligned with intracranial injury severity. Multifocal TBIs predominated in patients with cranial surgery. These findings summarise current TBI surgical practice across US trauma centres and provide

Published
2024

81. Research considerations for prospective studies of patients with coma and disorders of consciousness

Author

Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Da Cunha, Arthur Henrique Galvão Bruno, Hinson, Holly, Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L, Janas, Anna, Johnson, Susan, Jones, Morgan, Jox, Ralf J, Kalanuria, Atul, Keller, Emanuela, Kennedy, Lori, Kennelly, Megan, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matthew, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, MacDonald, Jennifer, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Mascia, Luciana, Massimini, Marcello, Mathur, Rohan, Mayer, Stephan, McCredie, Victoria, Mejia-Mantilla, Jorge, Mendoza, Michael, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, Zink, Elizabeth, Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, 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Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, and Zink, Elizabeth

Abstract

Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encountered as a consequence of both acute and chronic brain injuries, yet reliable epidemiological estimates would require inclusive, operational definitions of the concept, as well as wider knowledge dissemination among involved professionals. Whereas several manifestations have been described, including coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state, a comprehensive neurobiological definition for disorders of consciousness is still lacking. The scientific literature is primarily observational, and studies-specific aetiologies lead to disorders of consciousness. Despite advances in these disease-related forms, there remains uncertainty about whether disorders of consciousness are a disease-agnostic unitary entity with a common mechanism, prognosis or treatment response paradigm. Our knowledge of disorders of consciousness has also been hampered by heterogeneity of study designs, variables, and outcomes, leading to results that are not comparable for evidence synthesis. The different backgrounds of professionals caring for patients with disorders of consciousness and the different goals at different stages of care could partly explain this variability. The Prospective Studies working group of the Neurocritical Care Society Curing Coma Campaign was established to create a platform for observational studies and future clinical trials on disorders of consciousness and coma across the continuum of care. In this narrative review, the author panel presents limitations of prior observational clinical research and outlines practical considerations for future investigations. A narrative review format was selected to ensure that the full breadth of study design considerations could be addressed and to facilit

Published
2024

83. Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study

Author

Adeoye, Opeolu M, Badjatia, Neeraj, Boase, Kim, Bodien, Yelena G, Bullock, Malcom R, Chesnut, Randall M, Corrigan, John D, Crawford, Karen, Dikmen, Sureyya S, Duhaime, Ann-Christine, Ellenbogen, Richard G, Feeser, Venkata, Foreman, Brandon, Gardner, Raquel C, Gaudette, Etienne, Giacino, Joseph T, Goldman, Dana P, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, J C, Hotz, Gillian, Kramer, Joel H, Kreitzer, Natalie P, Levin, Harvey S, Lindsell, Christopher J, Machamer, Joan, Madden, Christopher J, Martin, Alastair J, McAllister, Thomas W, McCrea, Michael, Merchant, Randall, Nelson, Lindsay D, Noel, Florence, Palacios, Eva M, Perl, Daniel P, Puccio, Ava M, Rabinowitz, Miri, Robertson, Claudia S, Rosand, Jonathan, Sander, Angelle M, Satris, Gabriela G, Schnyer, David M, Seabury, Seth A, Sherer, Mark, Stein, Murray B, Temkin, Nancy R, Toga, Arthur W, Valadka, Alex B, Vassar, Mary J, Vespa, Paul M, Yuh, Esther L, Zafonte, Ross, Yue, John K, Korley, Frederick K, Winkler, Ethan A, Sun, Xiaoying, Puffer, Ross C, Deng, Hansen, Choy, Winward, Chandra, Ankush, Taylor, Sabrina R, Ferguson, Adam R, Huie, J Russell, Mukherjee, Pratik, Wang, Kevin K W, Diaz-Arrastia, Ramon, Okonkwo, David O, Jain, Sonia, and Manley, Geoffrey T

Published
2019
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85. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Author

Vespa, Paul M., Shrestha, Vikesh, Abend, Nicholas, Agoston, Denes, Au, Alicia, Bell, Michael J., Bleck, Thomas P., Blanco, Manuel Buitrago, Claassen, Jan, Diaz-Arrastia, Ramon, Duncan, Dominique, Ellingson, Ben, Foreman, Brandon, Gilmore, Emily J., Hirsch, Lawrence, Hunn, Martin, Kamnaksh, Alaa, McArthur, David, Morokoff, Andrew, O'Brien, Terrence, O'Phelan, Kristine, Robertson, Courtney L., Rosenthal, Eric, Staba, Richard, Toga, Arthur, Willyerd, Frederick A., Zimmermann, Lara, Yam, Elisa, Martinez, Susana, Real, Courtney, and Engel, Jerome, Jr

Published
2019
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88. Intracranial pressure-flow relationships in traumatic brain injury patients expose gaps in the tenets of models and pressure-oriented management.

Author

Stroh, J. N., Foreman, Brandon, Bennett, Tellen D., Briggs, Jennifer K., Park, Soojin, and Albers, David J.

Subjects
INTRACRANIAL pressure, BRAIN injuries, CEREBRAL circulation, BLOOD flow, BLENDED learning
Abstract

Background: The protocols and therapeutic guidance established for treating traumatic brain injury (TBI) in neurointensive care focus on managing cerebral blood flow (CBF) and brain tissue oxygenation based on pressure signals. The decision support process relies on assumed relationships between cerebral perfusion pressure (CPP) and blood flow, pressure-flow relationships (PFRs), and shares this framework of assumptions with mathematical intracranial hemodynamics models. These foundational assumptions are difficult to verify, and their violation can impact clinical decision-making and model validity. Methods: A hypothesis- and model-driven method for verifying and understanding the foundational intracranial hemodynamic PFRs is developed and applied to a novel multi-modality monitoring dataset. Results: Model analysis of joint observations of CPP and CBF validates the standard PFR when autoregulatory processes are impaired as well as unmodelable cases dominated by autoregulation. However, it also identifies a dynamical regime -or behavior pattern-where the PFR assumptions are wrong in a precise, data-inferable way due to negative CPP-CBF coordination over long timescales. This regime is of both clinical and research interest: its dynamics are modelable under modified assumptions while its causal direction and mechanistic pathway remain unclear. Conclusion: Motivated by the understanding of mathematical physiology, the validity of the standard PFR can be assessed a) directly by analyzing pressure reactivity and mean flow indices (PRx and Mx) or b) indirectly through the relationship between CBF and other clinical observables. This approach could potentially help to personalize TBI care by considering intracranial pressure and CPP in relation to other data, particularly CBF. The analysis suggests a threshold using clinical indices of autoregulation jointly generalizes independently set indicators to assess CA functionality. These results support the use of increasingly datarich environments to develop more robust hybrid physiological-machine learning models. [ABSTRACT FROM AUTHOR]

Published
2024
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91. Post–Intensive Care Syndrome in Neurocritical Care Patients.

Author

Dangayach, Neha S., Kreitzer, Natalie, Foreman, Brandon, and Tosto-Mancuso, Jenna

Subjects
INTENSIVE care units, NEUROLOGICAL intensive care, CAREGIVERS, PHYSICAL mobility, PATIENT care
Abstract

Post–intensive care syndrome (PICS) refers to unintended consequences of critical care that manifest as new or worsening impairments in physical functioning, cognitive ability, or mental health. As intensive care unit (ICU) survival continues to improve, PICS is becoming increasingly recognized as a public health problem. Studies that focus on PICS have typically excluded patients with acute brain injuries and chronic neurodegenerative problems. However, patients who require neurocritical care undoubtedly suffer from impairments that overlap substantially with those encompassed by PICS. A major challenge is to distinguish between impairments related to brain injury and those that occur as a consequence of critical care. The general principles for the prevention and management of PICS and multidomain impairments in patients with moderate and severe neurological injuries are similar including the ICU liberation bundle, multidisciplinary team-based care throughout the continuum of care, and increasing awareness regarding the challenges of critical care survivorship among patients, families, and multidisciplinary team members. An extension of this concept, PICS-Family (PICS-F) refers to the mental health consequences of the intensive care experience for families and loved ones of ICU survivors. A dyadic approach to ICU survivorship with an emphasis on recognizing families and caregivers that may be at risk of developing PICS-F after neurocritical care illness can help improve outcomes for ICU survivors. In this review, we will summarize our current understanding of PICS and PICS-F, emerging literature on PICS in severe acute brain injury, strategies for preventing and treating PICS, and share our recommendations for future directions. [ABSTRACT FROM AUTHOR]

Published
2024
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92. Inaugural State of the Union: Continuous Cerebral Autoregulation Monitoring in the Clinical Practice of Neurocritical Care and Anesthesia.

Author

Park, Soojin, Beqiri, Erta, Smielewski, Peter, Aries, Marcel, Abecasis, Francisco, Agrawal, Shruti, Appavu, Brian, Balu, Ramani, Brady, Ken, Brunsch, Celina, Budohoski, Karol, Czigler, András, Depreitere, Bart, Dias, Celeste, Enblad, Per, Ercole, Ari, Figaji, Anthony, Foreman, Brandon, Frisvold, Shirin K., and Gallagher, Clare

Subjects
CEREBRAL circulation, INTRACRANIAL pressure, CLINICAL trials monitoring, CRITICALLY ill, ANESTHESIA, BLOOD pressure
Abstract

How continuous cerebral autoregulation (CCA) knowledge should be optimally gained and interpreted is still an active area of research and refinement. We now experience a unique situation of having indices clinically available before definitive evidence of benefit or practice guidelines, in a moment when high rates of institutional variability exist both in the application of monitoring as well as in monitoring-guided treatments. Responses from 47 international clinicians, experts in this field, were collected with polling and discussion of the results. The clinical use of CCA in critical illness was not universal among experts, with 34% not using it. Of those who use a CCA index in clinical practice, 64% use intracranial pressure–based Pressure Reactivity index (PRx). There seems to exist a considerable trust in the physiologic plausibility of CCA to guide individual arterial blood pressure and cerebral perfusion pressure therapy and provide benefit, regardless of the difficulty of proving this. A total of 59% feel the need for phase II and III prospective studies but would continue to use CCA information in their practice even if randomized controlled trials (RCTs) did not show clear clinical benefit. There was nearly universal interest to participate in an RCT, with agreement that the research community must together determine end points and interventions to reduce wasted effort and time, and that investigations should include the following: the most appropriate way of inclusion of CCA into the clinical workflow; whether CCA-guided interventions should be prophylactic, proactive; or reactive; and whether a CCA-centric (unimodal) or a multimodal monitoring-integrated tiered therapy approach should be adopted. Pediatric and neonatal populations were highlighted as having urgent need and even more plausibility than adults. On the whole, the initiative was enthusiastically embraced by the experts, with the general feeling that a strong push should be now made by the community to convert the plausible benefits of CCA monitoring, already implemented in some centers, into a more standardized and RCT-validated clinical reality. [ABSTRACT FROM AUTHOR]

Published
2024
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93. Periodic EEG Patterns

Author

Grossman, Jonah, Foreman, Brandon, Tarsy, Daniel, Series editor, Drislane, Frank W., editor, and Kaplan MBBS, Peter W., editor

Published
2018
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100. Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury

Author

Harlan, Sarah Schuman, primary, Philpott, Carolyn D., additional, Keegan, Shaun P., additional, Droege, Molly E., additional, Karve, Aniruddha S., additional, Foreman, Brandon, additional, Wakefield, Devin, additional, Mueller, Eric W, additional, Sangha, Kiranpal, additional, Ngwenya, Laura B., additional, Courter, Joshua D., additional, Desai, Pankaj, additional, and Droege, Christopher, additional

Published
2023
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