Search

Your search keyword '"Garzoni, Christian"' showing total 440 results
Start Over Author "Garzoni, Christian"
440 results on '"Garzoni, Christian"'

51. BK Polyomavirus‐Specific 9mer CD8 T Cell Responses Correlate With Clearance of BK Viremia in Kidney Transplant Recipients: First Report From the Swiss Transplant Cohort Study

Author

Leboeuf, C., Wilk, S., Achermann, R., Binet, I., Golshayan, D., Hadaya, K., Hirzel, C., Hoffmann, M., Huynh‐Do, U., Koller, M. T., Manuel, O., Mueller, N. J., Mueller, T. F., Schaub, S., van Delden, C., Weissbach, F. H., Hirsch, H. H., Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hofbauer, Günther, Immer, Franz, Klaghofer, Richard, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Marti, Hans‐Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morel, Philippe, Mueller, Ulrike, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
Full Text
View/download PDF

52. The Swiss Transplant Cohort Study: Lessons from the First 6 Years

Author

Berger, Christoph, Bochud, Pierre-Yves, Boggian, Katja, Cusini, Alexia, Egli, Adrian, Garzoni, Christian, Hirsch, Hans H., Hoffmann, Matthias, Khanna, Nina, Manuel, Oriol, Meylan, Pascal, Nadal, David, van Delden, Christian, Weisser, Maja, Mueller, Nicolas J., and Transplant Infectious Diseases Working Group, Swiss Transplant Cohort Study

Published
2015
Full Text
View/download PDF

53. Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

Author

Marzi, Roberta, primary, Bassi, Jessica, additional, Silacci-Fregni, Chiara, additional, Bartha, Istvan, additional, Muoio, Francesco, additional, Culap, Katja, additional, Sprugasci, Nicole, additional, Lombardo, Gloria, additional, Saliba, Christian, additional, Cameroni, Elisabetta, additional, Cassotta, Antonino, additional, Low, Jun Siong, additional, Walls, Alexandra C., additional, McCallum, Matthew, additional, Tortorici, M. Alejandra, additional, Bowen, John E., additional, Dellota, Exequiel A., additional, Dillen, Josh R., additional, Czudnochowski, Nadine, additional, Pertusini, Laura, additional, Terrot, Tatiana, additional, Lepori, Valentino, additional, Tarkowski, Maciej, additional, Riva, Agostino, additional, Biggiogero, Maira, additional, Pellanda, Alessandra Franzetti, additional, Garzoni, Christian, additional, Ferrari, Paolo, additional, Ceschi, Alessandro, additional, Giannini, Olivier, additional, Havenar-Daughton, Colin, additional, Telenti, Amalio, additional, Arvin, Ann, additional, Virgin, Herbert W., additional, Sallusto, Federica, additional, Veesler, David, additional, Lanzavecchia, Antonio, additional, Corti, Davide, additional, and Piccoli, Luca, additional

Published
2022
Full Text
View/download PDF

54. ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

Author

Low, Jun Siong, primary, Jerak, Josipa, additional, Tortorici, M. Alejandra, additional, McCallum, Matthew, additional, Pinto, Dora, additional, Cassotta, Antonino, additional, Foglierini, Mathilde, additional, Mele, Federico, additional, Abdelnabi, Rana, additional, Weynand, Birgit, additional, Noack, Julia, additional, Montiel-Ruiz, Martin, additional, Bianchi, Siro, additional, Benigni, Fabio, additional, Sprugasci, Nicole, additional, Joshi, Anshu, additional, Bowen, John E., additional, Stewart, Cameron, additional, Rexhepaj, Megi, additional, Walls, Alexandra C., additional, Jarrossay, David, additional, Morone, Diego, additional, Paparoditis, Philipp, additional, Garzoni, Christian, additional, Ferrari, Paolo, additional, Ceschi, Alessandro, additional, Neyts, Johan, additional, Purcell, Lisa A., additional, Snell, Gyorgy, additional, Corti, Davide, additional, Lanzavecchia, Antonio, additional, Veesler, David, additional, and Sallusto, Federica, additional

Published
2022
Full Text
View/download PDF

55. Reply to Böning et al. Comment on “Ceruti et al. Temporal Changes in the Oxyhemoglobin Dissociation Curve of Critically Ill COVID-19 Patients. J. Clin. Med. 2022, 11, 788”

Author

Ceruti, Samuele, primary, Minotti, Bruno, additional, Glotta, Andrea, additional, Biggiogero, Maira, additional, Bona, Giovanni, additional, Marzano, Martino, additional, Greco, Pietro, additional, Spagnoletti, Marco, additional, Garzoni, Christian, additional, and Bendjelid, Karim, additional

Published
2022
Full Text
View/download PDF

56. Bloodstream infections in allogeneic haematopoietic cell recipients from the Swiss Transplant Cohort Study

Author

Weisser, Maja, primary, Sava, Mihaela, additional, Baettig, Veronika, additional, Gerull, Sabine, additional, Passweg, Jakob, additional, Khanna, Nina, additional, Garzoni, Christian, additional, Gerber, Bernhard, additional, Mueller, Nicolas, additional, Schanz, Urs, additional, Berger, Christoph, additional, Chalandon, Yves, additional, Delden, Christian van, additional, Neofytos, Dionysios, additional, Stampf, Susanne, additional, and Franzeck, Fabian, additional

Published
2022
Full Text
View/download PDF

57. P1245 Polymorphic Variants of HSD3B1 Gene Confer Different Outcome in Specific Subgroups of Patients Infected With SARS-CoV-2

Author

Epistolio, Samantha, primary, Ramelli, Giulia, additional, Ottaviano, Margaret, additional, Crupi, Emanuele, additional, Marandino, Laura, additional, Biggiogero, Maira, additional, Maida, Pier Andrea, additional, Ruinelli, Lorenzo, additional, Vogl, Ursula, additional, Mangan, Dylan, additional, Pascale, Mariarosa, additional, Cantù, Marco, additional, Ceschi, Alessandro, additional, Bernasconi, Enos, additional, Mazzucchelli, Luca, additional, Catapano, Carlo, additional, Alimonti, Andrea, additional, Garzoni, Christian, additional, Gillessen Sommer, Silke, additional, Stefanini, Federico Mattia, additional, Franzetti-Pellanda, Alessandra, additional, Frattini, Milo, additional, and Pereira Mestre, Ricardo, additional

Published
2022
Full Text
View/download PDF

58. The MELD upgrade exception: a successful strategy to optimize access to liver transplantation for patients with high waiting list mortality

Author

Dirchwolf, Melisa, primary, Becchetti, Chiara, additional, Gschwend, Sarah G., additional, Toso, Christian, additional, Dutkowski, Philipp, additional, Immer, Franz, additional, Beyeler, Franziska, additional, Rossi, Simona, additional, Schropp, Jonas, additional, Dufour, Jean-François, additional, Banz, Vanessa, additional, Amico, Patrizia, additional, Axel, Andres, additional, Aubert, John-David, additional, Sonja, Beckmann, additional, Beldi, Guido, additional, Benden, Christian, additional, Berger, Christoph, additional, Binet, Isabelle, additional, Bochud, Pierre-Yves, additional, Branca, Sanda, additional, Bucher, Heiner, additional, Carrel, Thierry, additional, Catana, Emmanuelle, additional, Chalandon, Yves, additional, de Geest, Sabina, additional, de Rougemont, Olivier, additional, Dickenmann, Michael, additional, Dreifuss, Joëlle L., additional, Duchosal, Michel, additional, Fehr, Thomas, additional, Ferrari-Lacraz, Sylvie, additional, Garzoni, Christian, additional, Soccal, Paola G., additional, Gaudet, Christophe, additional, Giostra, Emiliano, additional, Golshayan, Déla, additional, Hadaya, Karine, additional, Halter, Jörg, additional, Hauri, Dimitri, additional, Heim, Dominik, additional, Hess, Christoph, additional, Hillinger, Sven, additional, Hirsch, Hans, additional, Hirt, Patricia, additional, Hofbauer, Günther, additional, Huynh-Do, Uyen, additional, Koller, Michael, additional, Laesser, Bettina, additional, Lang, Brian, additional, Lehmann, Roger, additional, Leichtle, Alexander, additional, Lovis, Christian, additional, Manuel, Oriol, additional, Marti, Hans-Peter, additional, Martin, Pierre Y., additional, Martinelli, Michele, additional, Mellac, Katell, additional, Merçay, Aurélia, additional, Mettler, Karin, additional, Meylan, Pascal, additional, Mueller, Nicolas, additional, Müller, Antonia, additional, Müller, Thomas, additional, Müller-Arndt, Ulrike, additional, Müllhaupt, Beat, additional, Nägeli, Mirjam, additional, Pascual, Manuel, additional, Posfay-Barbe, Klara, additional, Rick, Juliane, additional, Rosselet, Anne, additional, Rothlin, Silvia, additional, Ruschitzka, Frank, additional, Schanz, Urs, additional, Schaub, Stefan, additional, Schnyder, Aurelia, additional, Schuurmans, Macé, additional, Simonetta, Federico, additional, Staufer, Katharina, additional, Stampf, Susanne, additional, Steiger, Jürg, additional, Stirniman, Guido, additional, Stürzinger, Ueli, additional, Van Delden, Christian, additional, Venetz, Jean-Pierre, additional, Villard, Jean, additional, Vionnet, Julien, additional, Wick, Madeleine, additional, Wilhlem, Markus, additional, and Yerly, Patrick, additional

Published
2022
Full Text
View/download PDF

60. P1245 Polymorphic Variants of HSD3B1 Gene Confer Different Outcome in Specific Subgroups of Patients Infected With SARS-CoV-2

Author

Epistolio, Samantha, Ramelli, Giulia, Ottaviano, Margaret, Crupi, Emanuele, Marandino, Laura, Biggiogero, Maira, Maida, Pier Andrea, Ruinelli, Lorenzo, Vogl, Ursula, Mangan, Dylan, Pascale, Mariarosa, Cantù, Marco, Ceschi, Alessandro, Bernasconi, Enos, Mazzucchelli, Luca, Catapano, Carlo, Alimonti, Andrea, Garzoni, Christian, Gillessen Sommer, Silke, Stefanini, Federico Mattia, Franzetti-Pellanda, Alessandra, Frattini, Milo, Pereira Mestre, Ricardo, Epistolio, Samantha, Ramelli, Giulia, Ottaviano, Margaret, Crupi, Emanuele, Marandino, Laura, Biggiogero, Maira, Maida, Pier Andrea, Ruinelli, Lorenzo, Vogl, Ursula, Mangan, Dylan, Pascale, Mariarosa, Cantù, Marco, Ceschi, Alessandro, Bernasconi, Enos, Mazzucchelli, Luca, Catapano, Carlo, Alimonti, Andrea, Garzoni, Christian, Gillessen Sommer, Silke, Stefanini, Federico Mattia, Franzetti-Pellanda, Alessandra, Frattini, Milo, and Pereira Mestre, Ricardo

Abstract

Introduction: Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the androgen receptor (AR), through ACE2 receptor and TMPRSS2, to enter nasal and upper airways epithelial cells. Genetic analyses revealed that HSD3B1 P1245C polymorphic variant increases dihydrotestosterone production and upregulation of TMPRSS2 with respect to P1245A variant, thus possibly influencing SARS-CoV-2 infection. Our aim was to characterize the HSD3B1 polymorphism status and its potential association with clinical outcomes in hospitalized patients with COVID-19 in Southern Switzerland. Materials and Methods: The cohort included 400 patients hospitalized for COVID-19 during the first wave between February and May 2020 in two different hospitals of Canton Ticino. Genomic DNA was extracted from formalin-fixed paraffin-embedded tissue blocks, and HSD3B1 gene polymorphism was evaluated by Sanger sequencing. Statistical associations were verified using different test. Results: HSD3B1 polymorphic variants were not associated with a single classical factor related to worse clinical prognosis in hospitalized patients with SARS-CoV-2. However, in specific subgroups, HSD3B1 variants played a clinical role: intensive care unit admission was more probable in patients with P1245C diabetes compared with P1245A individuals without this comorbidity and death was more associated with hypertensive P1245A>C cases than patients with P1245A diabetes without hypertension. Discussion: This is the first study showing that HSD3B1 gene status may influence the severity of SARS-CoV-2 infection. If confirmed, our results could lead to the introduction of HSD3B1 gene status analysis in patients infected with SARS-CoV-2 to predict clinical outcome. Keywords: HSD3B1 gene polymorphism; Likelihood-ratio tests; SARS-CoV-2; androgen receptor; direct sequencing.

Published
2022

61. ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

Author

Low, Jun Siong; https://orcid.org/0000-0002-1775-0778, Jerak, Josipa; https://orcid.org/0000-0001-5358-5055, Tortorici, M Alejandra; https://orcid.org/0000-0002-2260-2577, McCallum, Matthew; https://orcid.org/0000-0001-8398-8330, Pinto, Dora, Cassotta, Antonino; https://orcid.org/0000-0001-8674-4294, Foglierini, Mathilde; https://orcid.org/0000-0001-7538-4262, Mele, Federico; https://orcid.org/0000-0003-0455-4687, Abdelnabi, Rana; https://orcid.org/0000-0001-9771-7312, Weynand, Birgit; https://orcid.org/0000-0003-4246-6303, Noack, Julia; https://orcid.org/0000-0002-9113-8181, Montiel-Ruiz, Martin; https://orcid.org/0000-0001-6200-9578, Bianchi, Siro; https://orcid.org/0000-0002-5100-8905, Benigni, Fabio; https://orcid.org/0000-0002-1974-5606, Sprugasci, Nicole; https://orcid.org/0000-0003-3258-5552, Joshi, Anshu, Bowen, John E; https://orcid.org/0000-0003-3590-9727, Stewart, Cameron; https://orcid.org/0000-0002-2786-6256, Rexhepaj, Megi; https://orcid.org/0000-0002-8107-7231, Walls, Alexandra C; https://orcid.org/0000-0002-9636-8330, Jarrossay, David; https://orcid.org/0000-0002-0924-6395, Morone, Diego, Paparoditis, Philipp, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Ferrari, Paolo; https://orcid.org/0000-0002-9619-3104, Ceschi, Alessandro; https://orcid.org/0000-0002-4308-0405, Neyts, Johan; https://orcid.org/0000-0002-0033-7514, Purcell, Lisa A; https://orcid.org/0000-0002-9565-2030, Snell, Gyorgy; https://orcid.org/0000-0003-1475-659X, Corti, Davide; https://orcid.org/0000-0002-5797-1364, Lanzavecchia, Antonio, Veesler, David, Sallusto, Federica; https://orcid.org/0000-0003-3750-2752, Low, Jun Siong; https://orcid.org/0000-0002-1775-0778, Jerak, Josipa; https://orcid.org/0000-0001-5358-5055, Tortorici, M Alejandra; https://orcid.org/0000-0002-2260-2577, McCallum, Matthew; https://orcid.org/0000-0001-8398-8330, Pinto, Dora, Cassotta, Antonino; https://orcid.org/0000-0001-8674-4294, Foglierini, Mathilde; https://orcid.org/0000-0001-7538-4262, Mele, Federico; https://orcid.org/0000-0003-0455-4687, Abdelnabi, Rana; https://orcid.org/0000-0001-9771-7312, Weynand, Birgit; https://orcid.org/0000-0003-4246-6303, Noack, Julia; https://orcid.org/0000-0002-9113-8181, Montiel-Ruiz, Martin; https://orcid.org/0000-0001-6200-9578, Bianchi, Siro; https://orcid.org/0000-0002-5100-8905, Benigni, Fabio; https://orcid.org/0000-0002-1974-5606, Sprugasci, Nicole; https://orcid.org/0000-0003-3258-5552, Joshi, Anshu, Bowen, John E; https://orcid.org/0000-0003-3590-9727, Stewart, Cameron; https://orcid.org/0000-0002-2786-6256, Rexhepaj, Megi; https://orcid.org/0000-0002-8107-7231, Walls, Alexandra C; https://orcid.org/0000-0002-9636-8330, Jarrossay, David; https://orcid.org/0000-0002-0924-6395, Morone, Diego, Paparoditis, Philipp, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Ferrari, Paolo; https://orcid.org/0000-0002-9619-3104, Ceschi, Alessandro; https://orcid.org/0000-0002-4308-0405, Neyts, Johan; https://orcid.org/0000-0002-0033-7514, Purcell, Lisa A; https://orcid.org/0000-0002-9565-2030, Snell, Gyorgy; https://orcid.org/0000-0003-1475-659X, Corti, Davide; https://orcid.org/0000-0002-5797-1364, Lanzavecchia, Antonio, Veesler, David, and Sallusto, Federica; https://orcid.org/0000-0003-3750-2752

Abstract

The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion. Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that bind to all human-infecting coronavirus spike proteins from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune donors. These mAbs recognize the fusion peptide and acquire affinity and breadth through somatic mutations. Despite targeting a conserved motif, only some mAbs show broad neutralizing activity in vitro against alpha- and betacoronaviruses, including animal coronaviruses WIV-1 and PDF-2180. Two selected mAbs also neutralize Omicron BA.1 and BA.2 authentic viruses and reduce viral burden and pathology in vivo. Structural and functional analyses showed that the fusion peptide–specific mAbs bound with different modalities to a cryptic epitope hidden in prefusion stabilized spike, which became exposed upon binding of angiotensin-converting enzyme 2 (ACE2) or ACE2-mimicking mAbs.

Published
2022

62. Frailty assessment for COVID-19 follow-up: a prospective cohort study

Author

Müller, Ilena, Mancinetti, Marco, Renner, Anja, Bridevaux, Pierre-Olivier, Brutsche, Martin H, Clarenbach, Christian, Garzoni, Christian, Lenoir, Alexandra, Naccini, Bruno, Ott, Sebastian, Piquilloud, Lise; https://orcid.org/0000-0002-4226-8772, Prella, Maura, Que, Yok-Ai, Soccal, Paola Marina, von Garnier, Christophe, Geiser, Thomas K, Funke-Chambour, Manuela, Guler, Sabina, Müller, Ilena, Mancinetti, Marco, Renner, Anja, Bridevaux, Pierre-Olivier, Brutsche, Martin H, Clarenbach, Christian, Garzoni, Christian, Lenoir, Alexandra, Naccini, Bruno, Ott, Sebastian, Piquilloud, Lise; https://orcid.org/0000-0002-4226-8772, Prella, Maura, Que, Yok-Ai, Soccal, Paola Marina, von Garnier, Christophe, Geiser, Thomas K, Funke-Chambour, Manuela, and Guler, Sabina

Abstract

BackgroundThe Clinical Frailty Scale (CFS) is increasingly used for clinical decision making in acute care but little is known about frailty after COVID-19.ObjectivesTo investigate frailty and the CFS for post-COVID-19 follow-up.MethodsThis prospective multicentre cohort study included COVID-19 survivors aged ≥50 years presenting for a follow-up visit ≥3 months after the acute illness. Nine centres retrospectively collected pre-COVID-19 CFS and prospectively CFS at follow-up. Three centres completed the Frailty Index (FI), the short physical performance battery (SPPB), 30 s sit-to-stand test and handgrip strength measurements. Mixed effect logistic regression models accounting for repeated measurements and potential confounders were used to investigate factors associated with post-COVID-19 CFS. Criterion and construct validity were determined by correlating the CFS to other concurrently assessed frailty measurements and measures of respiratory impairment, respectively.ResultsOf the 288 participants 65% were men, mean (SD) age was 65.1 (9) years. Median (IQR) CFS at follow-up was 3 (2–3), 21% were vulnerable or frail (CFS ≥4). The CFS was responsive to change, correlated with the FI (r=0.69, p<0.001), the SPPB score (r=−0.48, p<0.001) (criterion validity) and with the St George’s Respiratory Questionnaire score (r=0.59, p<0.001), forced vital capacity %-predicted (r=−0.25, p<0.001), 6 min walk distance (r=−0.39, p<0.001) and modified Medical Research Council (mMRC) (r=0.59, p<0.001). Dyspnoea was significantly associated with a higher odds for vulnerability/frailty (per one mMRC adjusted OR 2.01 (95% CI 1.13 to 3.58), p=0.02).ConclusionsThe CFS significantly increases with COVID-19, and dyspnoea is an important risk factor for post-COVID-19 frailty and should be addressed thoroughly.

Published
2022

63. Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

Author

Marzi, Roberta, Bassi, Jessica, Silacci-Fregni, Chiara, Bartha, Istvan, Muoio, Francesco, Culap, Katja, Sprugasci, Nicole, Lombardo, Gloria, Saliba, Christian, Cameroni, Elisabetta, Cassotta, Antonino, Low, Jun Siong, Walls, Alexandra C, McCallum, Matthew, Tortorici, M Alejandra; https://orcid.org/0000-0002-2260-2577, Bowen, John E, Dellota, Exequiel A, Dillen, Josh R, Czudnochowski, Nadine; https://orcid.org/0000-0002-3146-4110, Pertusini, Laura, Terrot, Tatiana, Lepori, Valentino, Tarkowski, Maciej, Riva, Agostino, Biggiogero, Maira, Pellanda, Alessandra Franzetti, Garzoni, Christian, Ferrari, Paolo; https://orcid.org/0000-0002-9619-3104, Ceschi, Alessandro; https://orcid.org/0000-0002-4308-0405, Giannini, Olivier, Sallusto, Federica; https://orcid.org/0000-0003-3750-2752, Lanzavecchia, Antonio, Corti, Davide; https://orcid.org/0000-0002-5797-1364, Piccoli, Luca, et al, Marzi, Roberta, Bassi, Jessica, Silacci-Fregni, Chiara, Bartha, Istvan, Muoio, Francesco, Culap, Katja, Sprugasci, Nicole, Lombardo, Gloria, Saliba, Christian, Cameroni, Elisabetta, Cassotta, Antonino, Low, Jun Siong, Walls, Alexandra C, McCallum, Matthew, Tortorici, M Alejandra; https://orcid.org/0000-0002-2260-2577, Bowen, John E, Dellota, Exequiel A, Dillen, Josh R, Czudnochowski, Nadine; https://orcid.org/0000-0002-3146-4110, Pertusini, Laura, Terrot, Tatiana, Lepori, Valentino, Tarkowski, Maciej, Riva, Agostino, Biggiogero, Maira, Pellanda, Alessandra Franzetti, Garzoni, Christian, Ferrari, Paolo; https://orcid.org/0000-0002-9619-3104, Ceschi, Alessandro; https://orcid.org/0000-0002-4308-0405, Giannini, Olivier, Sallusto, Federica; https://orcid.org/0000-0003-3750-2752, Lanzavecchia, Antonio, Corti, Davide; https://orcid.org/0000-0002-5797-1364, Piccoli, Luca, and et al

Abstract

SUMMARYMemory B cells (MBCs) generate rapid antibody responses upon secondary encounter with a pathogen. Here, we investigated the kinetics, avidity and cross-reactivity of serum antibodies and MBCs in 155 SARS-CoV-2 infected and vaccinated individuals over a 16-month timeframe. SARS-CoV-2-specific MBCs and serum antibodies reached steady-state titers with comparable kinetics in infected and vaccinated individuals. Whereas MBCs of infected individuals targeted both pre- and postfusion Spike (S), most vaccine-elicited MBCs were specific for prefusion S, consistent with the use of prefusion-stabilized S in mRNA vaccines. Furthermore, a large fraction of MBCs recognizing postfusion S cross-reacted with human betacoronaviruses. The avidity of MBC-derived and serum antibodies increased over time resulting in enhanced resilience to viral escape by SARS-CoV-2 variants, including Omicron BA.1 and BA.2 sub-lineages, albeit only partially for BA.4 and BA.5 sublineages. Overall, the maturation of high-affinity and broadly-reactive MBCs provides the basis for effective recall responses to future SARS-CoV-2 variants.

Published
2022

64. Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

Author

Pham, Truong-Thanh; https://orcid.org/0000-0003-0284-7080, Andrey, Diego O; https://orcid.org/0000-0003-3247-9274, Stampf, Susanne; https://orcid.org/0000-0003-3399-5078, Burkhard, Sara H, Hirzel, Cédric; https://orcid.org/0000-0002-7870-912X, Tschopp, Johnathan; https://orcid.org/0000-0002-9369-937X, Ullrich, Kathrin, Strahm, Carol, Schreiber, Peter W; https://orcid.org/0000-0001-8123-2601, Boillat-Blanco, Noémie; https://orcid.org/0000-0002-2490-8174, Garzoni, Christian, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Manuel, Oriol; https://orcid.org/0000-0001-7607-0943, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Suva, Domizio, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Uçkay, Ilker, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Pham, Truong-Thanh; https://orcid.org/0000-0003-0284-7080, Andrey, Diego O; https://orcid.org/0000-0003-3247-9274, Stampf, Susanne; https://orcid.org/0000-0003-3399-5078, Burkhard, Sara H, Hirzel, Cédric; https://orcid.org/0000-0002-7870-912X, Tschopp, Johnathan; https://orcid.org/0000-0002-9369-937X, Ullrich, Kathrin, Strahm, Carol, Schreiber, Peter W; https://orcid.org/0000-0001-8123-2601, Boillat-Blanco, Noémie; https://orcid.org/0000-0002-2490-8174, Garzoni, Christian, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Manuel, Oriol; https://orcid.org/0000-0001-7607-0943, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Suva, Domizio, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Uçkay, Ilker, and Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869

Abstract

Bone and joint infection (BJI) epidemiology and outcomes in solid organ transplant recipients (SOTr) remain largely unknown. We aim to describe BJI in a multi-center cohort of SOTr (Swiss Transplant Cohort Study). All consecutive SOTr with BJI (01.05.2008-31.12.2019) were included. A nested case-control study to identify risk factors for BJI was performed. Among 4482 patients, 61 SOTr with 82 BJI were included, at an incidence of 1.4% (95% CI 1.1-1.7), higher in heart and kidney-pancreas SOTr (Gray's test p < .01). Although BJI were predominately late events (median of 18.5 months post-SOT), most infections occurred during the first year post-transplant in thoracic SOTr. Diabetic foot osteomyelitis was the most frequent infection (38/82, 46.3%), followed by non-vertebral osteomyelitis (26/82, 31.7%). Pathogens included Gram-positive cocci (70/131, 53.4%), Gram-negative bacilli (34/131, 26.0%), and fungi (9/131, 6.9%). BJI predictors included male gender (OR 2.94, 95% CI 1.26-6.89) and diabetes (OR 2.97, 95% CI 1.34-6.56). Treatment failure was observed in 25.9% (21/81) patients and 1-year mortality post-BJI diagnosis was 14.8% (9/61). BJI remain a rare event in SOTr, associated with subtle clinical presentations, high morbidity and relapses, requiring additional studies in the future.

Published
2022

65. Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course

Author

Muri, Jonathan; https://orcid.org/0000-0002-6476-3766, Cecchinato, Valentina; https://orcid.org/0000-0001-7415-8706, Cavalli, Andrea; https://orcid.org/0000-0003-4063-4502, Shanbhag, Akanksha A; https://orcid.org/0000-0002-1676-2478, Matkovic, Milos; https://orcid.org/0000-0002-4872-1996, Biggiogero, Maira, Maida, Pier Andrea, Toscano, Chiara; https://orcid.org/0000-0002-0309-946X, Ghovehoud, Elaheh; https://orcid.org/0000-0002-0366-2670, Danelon-Sargenti, Gabriela, Gong, Tao; https://orcid.org/0000-0002-9414-6902, Piffaretti, Pietro; https://orcid.org/0000-0001-7621-0475, Bianchini, Filippo; https://orcid.org/0000-0002-0746-7629, Crivelli, Virginia; https://orcid.org/0000-0003-2494-7242, Podešvová, Lucie; https://orcid.org/0000-0003-1054-2252, Pedotti, Mattia; https://orcid.org/0000-0003-1370-9505, Jarrossay, David; https://orcid.org/0000-0002-0924-6395, Sgrignani, Jacopo; https://orcid.org/0000-0002-8633-1032, Thelen, Sylvia, Uhr, Mario, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Rauch, Andri; https://orcid.org/0000-0001-5297-6062, Manzo, Antonio; https://orcid.org/0000-0002-9743-6008, Ciurea, Adrian; https://orcid.org/0000-0002-7870-7132, Rocchi, Marco B L; https://orcid.org/0000-0002-0056-5795, Varani, Luca; https://orcid.org/0000-0002-0963-0987, Moser, Bernhard, Thelen, Marcus; https://orcid.org/0000-0002-3443-1605, Garzoni, Christian, Franzetti-Pellanda, Alessandra, Uguccioni, Mariagrazia, Robbiani, Davide F, Muri, Jonathan; https://orcid.org/0000-0002-6476-3766, Cecchinato, Valentina; https://orcid.org/0000-0001-7415-8706, Cavalli, Andrea; https://orcid.org/0000-0003-4063-4502, Shanbhag, Akanksha A; https://orcid.org/0000-0002-1676-2478, Matkovic, Milos; https://orcid.org/0000-0002-4872-1996, Biggiogero, Maira, Maida, Pier Andrea, Toscano, Chiara; https://orcid.org/0000-0002-0309-946X, Ghovehoud, Elaheh; https://orcid.org/0000-0002-0366-2670, Danelon-Sargenti, Gabriela, Gong, Tao; https://orcid.org/0000-0002-9414-6902, Piffaretti, Pietro; https://orcid.org/0000-0001-7621-0475, Bianchini, Filippo; https://orcid.org/0000-0002-0746-7629, Crivelli, Virginia; https://orcid.org/0000-0003-2494-7242, Podešvová, Lucie; https://orcid.org/0000-0003-1054-2252, Pedotti, Mattia; https://orcid.org/0000-0003-1370-9505, Jarrossay, David; https://orcid.org/0000-0002-0924-6395, Sgrignani, Jacopo; https://orcid.org/0000-0002-8633-1032, Thelen, Sylvia, Uhr, Mario, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Rauch, Andri; https://orcid.org/0000-0001-5297-6062, Manzo, Antonio; https://orcid.org/0000-0002-9743-6008, Ciurea, Adrian; https://orcid.org/0000-0002-7870-7132, Rocchi, Marco B L; https://orcid.org/0000-0002-0056-5795, Varani, Luca; https://orcid.org/0000-0002-0963-0987, Moser, Bernhard, Thelen, Marcus; https://orcid.org/0000-0002-3443-1605, Garzoni, Christian, Franzetti-Pellanda, Alessandra, Uguccioni, Mariagrazia, and Robbiani, Davide F

Abstract

Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 and autoimmune disorders, but they target different chemokines than those in COVID-19. Finally, monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential. One-sentence summary: Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and are predictive of lack of long COVID.

Published
2022

67. Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course

Author

Muri, Jonathan, primary, Cecchinato, Valentina, additional, Cavalli, Andrea, additional, Shanbhag, Akanksha A., additional, Matkovic, Milos, additional, Biggiogero, Maira, additional, Maida, Pier Andrea, additional, Moritz, Jacques, additional, Toscano, Chiara, additional, Ghovehoud, Elaheh, additional, Furlan, Raffaello, additional, Barbic, Franca, additional, Voza, Antonio, additional, Nadai, Guendalina De, additional, Cervia, Carlo, additional, Zurbuchen, Yves, additional, Taeschler, Patrick, additional, Murray, Lilly A., additional, Danelon-Sargenti, Gabriela, additional, Moro, Simone, additional, Gong, Tao, additional, Piffaretti, Pietro, additional, Bianchini, Filippo, additional, Crivelli, Virginia, additional, Podešvová, Lucie, additional, Pedotti, Mattia, additional, Jarrossay, David, additional, Sgrignani, Jacopo, additional, Thelen, Sylvia, additional, Uhr, Mario, additional, Bernasconi, Enos, additional, Rauch, Andri, additional, Manzo, Antonio, additional, Ciurea, Adrian, additional, Rocchi, Marco B.L., additional, Varani, Luca, additional, Moser, Bernhard, additional, Bottazzi, Barbara, additional, Thelen, Marcus, additional, Fallon, Brian A., additional, Boyman, Onur, additional, Mantovani, Alberto, additional, Garzoni, Christian, additional, Franzetti-Pellanda, Alessandra, additional, Uguccioni, Mariagrazia, additional, and Robbiani, Davide F., additional

Published
2022
Full Text
View/download PDF

68. A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2

Author

Albrich, Werner C., primary, Ghosh, Tarini Shankar, additional, Ahearn-Ford, Sinead, additional, Mikaeloff, Flora, additional, Lunjani, Nonhlanhla, additional, Forde, Brian, additional, Suh, Noémie, additional, Kleger, Gian-Reto, additional, Pietsch, Urs, additional, Frischknecht, Manuel, additional, Garzoni, Christian, additional, Forlenza, Rossella, additional, Horgan, Mary, additional, Sadlier, Corinna, additional, Negro, Tommaso Rochat, additional, Pugin, Jérôme, additional, Wozniak, Hannah, additional, Cerny, Andreas, additional, Neogi, Ujjwal, additional, O’Toole, Paul W., additional, and O’Mahony, Liam, additional

Published
2022
Full Text
View/download PDF

69. Frailty assessment for COVID-19 follow-up: a prospective cohort study

Author

Müller, Ilena, primary, Mancinetti, Marco, additional, Renner, Anja, additional, Bridevaux, Pierre-Olivier, additional, Brutsche, Martin H, additional, Clarenbach, Christian, additional, Garzoni, Christian, additional, Lenoir, Alexandra, additional, Naccini, Bruno, additional, Ott, Sebastian, additional, Piquilloud, Lise, additional, Prella, Maura, additional, Que, Yok-Ai, additional, Soccal, Paola Marina, additional, von Garnier, Christophe, additional, Geiser, Thomas K, additional, Funke-Chambour, Manuela, additional, and Guler, Sabina, additional

Published
2022
Full Text
View/download PDF

70. SARS-CoV-2 B.1.1.7 sensitivity to mRNA vaccine-elicited, convalescent and monoclonal antibodies

Author

Collier, Dami A, De Marco, Anna, Ferreira, Isabella ATM, Meng, Bo, Datir, Rawlings, Walls, Alexandra C, Kemp S, Steven A, Bassi, Jessica, Pinto, Dora, Fregni, Chiara Silacci, Bianchi, Siro, Tortorici, M Alejandra, Bowen, John, Culap, Katja, Jaconi, Stefano, Cameroni, Elisabetta, Snell, Gyorgy, Pizzuto, Matteo S, Pellanda, Alessandra Franzetti, Garzoni, Christian, Riva, Agostino, CITIID-NIHR BioResource COVID-19 Collaboration, Elmer, Anne, Kingston, Nathalie, Graves, Barbara, McCoy, Laura E, Smith, Kenneth Gc, Bradley, John R, Temperton, Nigel, Ceron-Gutierrez L, Lourdes, Barcenas-Morales, Gabriela, COVID-19 Genomics UK (COG-UK) Consortium, Harvey, William, Virgin, Herbert W, Lanzavecchia, Antonio, Piccoli, Luca, Doffinger, Rainer, Wills, Mark, Veesler, David, Corti, Davide, Gupta, Ravindra K, Datir, Rawlings [0000-0003-0521-2144], Smith, Kenneth [0000-0003-3829-4326], Bradley, John [0000-0002-7774-8805], Wills, Mark [0000-0001-8548-5729], and Apollo - University of Cambridge Repository

Subjects
The COVID-19 Genomics UK (COG-UK) consortium, The CITIID-NIHR BioResource COVID-19 Collaboration
Abstract

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) transmission is uncontrolled in many parts of the world, compounded in some areas by higher transmission potential of the B1.1.7 variant now seen in 50 countries. It is unclear whether responses to SARS-CoV-2 vaccines based on the prototypic strain will be impacted by mutations found in B.1.1.7. Here we assessed immune responses following vaccination with mRNA-based vaccine BNT162b2. We measured neutralising antibody responses following a single immunization using pseudoviruses expressing the wild-type Spike protein or the 8 amino acid mutations found in the B.1.1.7 spike protein. The vaccine sera exhibited a broad range of neutralising titres against the wild-type pseudoviruses that were modestly reduced against B.1.1.7 variant. This reduction was also evident in sera from some convalescent patients. Decreased B.1.1.7 neutralisation was also observed with monoclonal antibodies targeting the N-terminal domain (9 out of 10), the Receptor Binding Motif (RBM) (5 out of 31), but not in neutralising mAbs binding outside the RBM. Introduction of the E484K mutation in a B.1.1.7 background to reflect newly emerging viruses in the UK led to a more substantial loss of neutralising activity by vaccine-elicited antibodies and mAbs (19 out of 31) over that conferred by the B.1.1.7 mutations alone. E484K emergence on a B.1.1.7 background represents a threat to the vaccine BNT162b.

Published
2022
Full Text
View/download PDF

71. Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course

Author

Muri, Jonathan, Cecchinato, Valentina, Cavalli, Andrea, Shanbhag, Akanksha A, Matkovic, Milos, Biggiogero, Maira, Maida, Pier Andrea, Toscano, Chiara, Ghovehoud, Elaheh, Danelon-Sargenti, Gabriela, Gong, Tao, Piffaretti, Pietro, Bianchini, Filippo, Crivelli, Virginia, Podešvová, Lucie, Pedotti, Mattia, Jarrossay, David, Sgrignani, Jacopo, Thelen, Sylvia, Uhr, Mario, Bernasconi, Enos, Rauch, Andri, Manzo, Antonio, Ciurea, Adrian, Rocchi, Marco B L, Varani, Luca, Moser, Bernhard, Thelen, Marcus, Garzoni, Christian, Franzetti-Pellanda, Alessandra, Uguccioni, Mariagrazia, Robbiani, Davide F, and University of Zurich

Subjects
10051 Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health
Abstract

Infection by SARS-CoV-2 leads to diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse COVID-19 outcomes. Instead, we discovered that antibodies against specific chemokines are omnipresent after COVID-19, associated with favorable disease, and predictive of lack of long COVID symptoms at one year post infection. Anti-chemokine antibodies are present also in HIV-1 and autoimmune disorders, but they target different chemokines than those in COVID-19. Finally, monoclonal antibodies derived from COVID- 19 convalescents that bind to the chemokine N-loop impair cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising anti-chemokine antibodies associated with favorable COVID-19 may be beneficial by modulating the inflammatory response and thus bear therapeutic potential. One-Sentence Summary Naturally arising anti-chemokine antibodies associate with favorable COVID-19 and are predictive of lack of long COVID.

Published
2022
Full Text
View/download PDF

72. ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study

Author

Mauthner, Oliver, Claes, Veerle, Walston, Jeremy, Engberg, Sandra, Binet, Isabelle, Dickenmann, Michael, Golshayan, Déla, Hadaya, Karine, Huynh‐Do, Uyen, Calciolari, Stefano, De Geest, Sabina, Berben, Lut, Burkhalter, Hanna, Denhaerynck, Kris, Helmy, Remon, Kirsch, Monika, Leppla, Lynn, Struker, Marian, Boehler, Annette, Gerull, Sabine, Koller, Michael T, Boely, Elsa, Catana, Emmanuelle, Simcox, Amira, Seiler, Annina, Klaghofer, Richard, Künzler‐Heule, Patrizia, Beckmann, Sonja, Achermann, Rita, Amico, Patrizia, Aubert, John‐David, Baumann, Philippe, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Boely, Elsa, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Rougemont, Olivier, Duchosal, Michel, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Giostra, Emiliano, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Immer, Franz, Klaghofer, Richard, Koller, Michael, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Manuel, Oriol, Marti, Hans‐Peter, Martin, Pierre Yves, Martinolli, Luca, Meylan, Pascal, Mohacsi, Paul, Morard, Isabelle, Morel, Philippe, Mueller, Ulrike, Mueller, Nicolas J, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Ziegler, Chantal Piot, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
Full Text
View/download PDF

74. ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

Author

Low, Jun Siong, primary, Jerak, Josipa, additional, Tortorici, M. Alejandra, additional, McCallum, Matthew, additional, Pinto, Dora, additional, Cassotta, Antonino, additional, Foglierini, Mathilde, additional, Mele, Federico, additional, Abdelnabi, Rana, additional, Weynand, Birgit, additional, Noack, Julia, additional, Montiel-Ruiz, Martin, additional, Bianchi, Siro, additional, Benigni, Fabio, additional, Sprugasci, Nicole, additional, Joshi, Anshu, additional, Bowen, John E., additional, Walls, Alexandra C., additional, Jarrossay, David, additional, Morone, Diego, additional, Paparoditis, Philipp, additional, Garzoni, Christian, additional, Ferrari, Paolo, additional, Ceschi, Alessandro, additional, Neyts, Johan, additional, Purcell, Lisa A., additional, Snell, Gyorgy, additional, Corti, Davide, additional, Lanzavecchia, Antonio, additional, Veesler, David, additional, and Sallusto, Federica, additional

Published
2022
Full Text
View/download PDF

76. Low PEEP Mechanical Ventilation and PaO 2/FiO 2 Ratio Evolution in COVID-19 Patients

Author

Ceruti, Samuele, Roncador, Marco, Saporito, Andrea, Biggiogero, Maira, Glotta, Andrea, Maida, Pier Andrea, Urso, Patrizia, Bona, Giovanni, Garzoni, Christian, Mauri, Romano, Borgeat, Alain, and University of Zurich

Subjects
10032 Clinic for Oncology and Hematology, 610 Medicine & health, 10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center
Published
2021

78. Pulmonary Recovery 12 Months after Non-Severe and Severe COVID-19: The Prospective Swiss COVID-19 Lung Study.

Author

Lenoir, Alexandra, Christe, Andreas, Ebner, Lukas, Beigelman-Aubry, Catherine, Bridevaux, Pierre-Olivier, Brutsche, Martin, Clarenbach, Christian, Erkosar, Berra, Garzoni, Christian, Geiser, Thomas, Guler, Sabina A., Heg, Dik, Lador, Frédéric, Mancinetti, Marco, Ott, Sebastian R., Piquilloud, Lise, Prella, Maura, Que, Yok-Ai, von Garnier, Christophe, and Funke-Chambour, Manuela

Subjects
LUNG physiology, COVID-19, CHEST X rays, CONVALESCENCE, LUNGS, OXYGEN saturation, RESPIRATORY measurements, SEVERITY of illness index, VITAL capacity (Respiration), PULMONARY function tests, RESEARCH funding, LONGITUDINAL method
Abstract

Background: Lung function impairment persists in some patients for months after acute coronavirus disease 2019 (COVID-19). Long-term lung function, radiological features, and their association remain to be clarified. Objectives: We aimed to prospectively investigate lung function and radiological abnormalities over 12 months after severe and non-severe COVID-19. Methods: 584 patients were included in the Swiss COVID-19 lung study. We assessed lung function at 3, 6, and 12 months after acute COVID-19 and compared chest computed tomography (CT) imaging to lung functional abnormalities. Results: At 12 months, diffusion capacity for carbon monoxide (DLCOcorr) was lower after severe COVID-19 compared to non-severe COVID-19 (74.9% vs. 85.2% predicted, p < 0.001). Similarly, minimal oxygen saturation on 6-min walk test and total lung capacity were lower after severe COVID-19 (89.6% vs. 92.2%, p = 0.004, respectively, 88.2% vs. 95.1% predicted, p = 0.011). The difference for forced vital capacity (91.6% vs. 96.3% predicted, p = 0.082) was not statistically significant. Between 3 and 12 months, lung function improved in both groups and differences in DLCO between non-severe and severe COVID-19 patients decreased. In patients with chest CT scans at 12 months, we observed a correlation between radiological abnormalities and reduced lung function. While the overall extent of radiological abnormalities diminished over time, the frequency of mosaic attenuation and curvilinear patterns increased. Conclusions: In this prospective cohort study, patients who had severe COVID-19 had diminished lung function over the first year compared to those after non-severe COVID-19, albeit with a greater extent of recovery in the severe disease group. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

79. Differences Between Infectious Disease Events in First Liver Transplant Versus Retransplantation in the Swiss Transplant Cohort Study

Author

Kusejko, Katharina, Neofytos, Dionysios, Hirsch, Hans H, Meylan, Pascal, Boggian, Katia, Hirzel, Cedric, Garzoni, Christian, Kouyos, Roger D, Mueller, Nicolas J, Schreiber, Peter W, Swiss Transplant Cohort Study, University of Zurich, Kusejko, Katharina, and Schreiber, Peter W

Subjects
10234 Clinic for Infectious Diseases, 10028 Institute of Medical Virology, 2747 Transplantation, 610 Medicine & health, 2721 Hepatology, 2746 Surgery
Published
2021

80. Association of Antiviral Prophylaxis and Rituximab Use with Post-transplant Lymphoproliferative Disorders (PTLD): A Nationwide Cohort Study

Author

Walti, Laura N, Mugglin, Catrina, Sidler, Daniel, Mombelli, Matteo, Manuel, Oriol, Hirsch, Hans H, Khanna, Nina, Mueller, Nicolas, Berger, Christoph, Boggian, Katia, Garzoni, Christian, Neofytos, Dionysios, van Delden, Christian, Hirzel, Cédric, University of Zurich, and Walti, Laura N

Subjects
10234 Clinic for Infectious Diseases, 10036 Medical Clinic, 2747 Transplantation, 2723 Immunology and Allergy, 2736 Pharmacology (medical), 610 Medicine & health
Published
2021

81. Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Author

Cameroni, Elisabetta, primary, Bowen, John E., additional, Rosen, Laura E., additional, Saliba, Christian, additional, Zepeda, Samantha K., additional, Culap, Katja, additional, Pinto, Dora, additional, VanBlargan, Laura A., additional, De Marco, Anna, additional, di Iulio, Julia, additional, Zatta, Fabrizia, additional, Kaiser, Hannah, additional, Noack, Julia, additional, Farhat, Nisar, additional, Czudnochowski, Nadine, additional, Havenar-Daughton, Colin, additional, Sprouse, Kaitlin R., additional, Dillen, Josh R., additional, Powell, Abigail E., additional, Chen, Alex, additional, Maher, Cyrus, additional, Yin, Li, additional, Sun, David, additional, Soriaga, Leah, additional, Bassi, Jessica, additional, Silacci-Fregni, Chiara, additional, Gustafsson, Claes, additional, Franko, Nicholas M., additional, Logue, Jenni, additional, Iqbal, Najeeha Talat, additional, Mazzitelli, Ignacio, additional, Geffner, Jorge, additional, Grifantini, Renata, additional, Chu, Helen, additional, Gori, Andrea, additional, Riva, Agostino, additional, Giannini, Olivier, additional, Ceschi, Alessandro, additional, Ferrari, Paolo, additional, Cippà, Pietro E., additional, Franzetti-Pellanda, Alessandra, additional, Garzoni, Christian, additional, Halfmann, Peter J., additional, Kawaoka, Yoshihiro, additional, Hebner, Christy, additional, Purcell, Lisa A., additional, Piccoli, Luca, additional, Pizzuto, Matteo Samuele, additional, Walls, Alexandra C., additional, Diamond, Michael S., additional, Telenti, Amalio, additional, Virgin, Herbert W., additional, Lanzavecchia, Antonio, additional, Snell, Gyorgy, additional, Veesler, David, additional, and Corti, Davide, additional

Published
2021
Full Text
View/download PDF

83. Excessive inflammatory and metabolic responses to acute SARS-CoV-2 infection are associated with a distinct gut microbiota composition

Author

Albrich, Werner C., primary, Ghosh, Tarini Shankar, additional, Ahearn-Ford, Sinead, additional, Mikaeloff, Flora, additional, Lunjani, Nonhlanhla, additional, Forde, Brian, additional, Suh, Noémie, additional, Kleger, Gian-Reto, additional, Pietsch, Urs, additional, Frischknecht, Manuel, additional, Garzoni, Christian, additional, Forlenza, Rossella, additional, Horgan, Mary, additional, Sadlier, Corinna, additional, Negro, Tommaso Rochat, additional, Pugin, Jérôme, additional, Wozniak, Hannah, additional, Cerny, Andreas, additional, Neogi, Ujjwal, additional, O’Toole, Paul W., additional, and O’Mahony, Liam, additional

Published
2021
Full Text
View/download PDF

84. Use of induction therapy in pediatric heart transplant recipients in Switzerland – Analysis of the Swiss national database

Author

Schweiger, M., primary, Erdil, T., additional, Di Bernardo, S., additional, Balmer, C., additional, Yildiz, M., additional, Kadner, A., additional, Amico, Patrizia, additional, Axel, Andres, additional, Aubert, John-David, additional, Banz, Vanessa, additional, Sonja, Beckmann, additional, Beldi, Guido, additional, Berger, Christoph, additional, Berishvili, Ekaterine, additional, Binet, Isabelle, additional, Bochud, Pierre-Yves, additional, Branca, Sanda, additional, Bucher, Heiner, additional, Carrel, Thierry, additional, Catana, Emmanuelle, additional, Chalandon, Yves, additional, De Geest, Sabina, additional, De Rougemont, Olivier, additional, Dickenmann, Michael, additional, Dreifuss, Joëlle Lynn, additional, Duchosal, Michel, additional, Fehr, Thomas, additional, Ferrari-Lacraz, Sylvie, additional, Garzoni, Christian, additional, Soccal, Paola Gasche, additional, Gaudet, Christophe, additional, Golshayan, Déla, additional, Goossens, Nicolas, additional, Hadaya, Karine, additional, Halter, Jörg, additional, Heim, Dominik, additional, Hess, Christoph, additional, Hillinger, Sven, additional, Hirsch, Hans, additional, Hirt, Patricia, additional, Hofbauer, Günther, additional, Huynh-Do, Uyen, additional, Immer, Franz, additional, Koller, Michael, additional, Laager, Mirjam, additional, Laesser, Bettina, additional, Lehmann, Roger, additional, Leichtle, Alexander, additional, Lovis, Christian, additional, Manuel, Oriol, additional, Marti, Hans-Peter, additional, Martin, Pierre Yves, additional, Martinelli, Michele, additional, McLin, Valérie, additional, Mellac, Katell, additional, Merçay, Aurélia, additional, Mettler, Karin, additional, Mueller, Nicolas, additional, Müller, Antonia, additional, Müller, Thomas, additional, Müller-Arndt, Ulrike, additional, Müllhaupt, Beat, additional, Nägeli, Mirjam, additional, Oldani, Graziano, additional, Pascual, Manuel, additional, Posfay-Barbe, Klara, additional, Rick, Juliane, additional, Rosselet, Anne, additional, Rossi, Simona, additional, Rothlin, Silvia, additional, Ruschitzka, Frank, additional, Schanz, Urs, additional, Schaub, Stefan, additional, Schnyder, Aurelia, additional, Schuurmans, Macé, additional, Sengstag, Thierry, additional, Simonetta, Federico, additional, Staufer, Katharina, additional, Stampf, Susanne, additional, Steiger, Jürg, additional, Stirniman, Guido, additional, Stürzinger, Ueli, additional, Van Delden, Christian, additional, Venetz, Jean-Pierre, additional, Villard, Jean, additional, Vionnet, Julien, additional, Wick, Madeleine, additional, Wilhlem, Markus, additional, and Yerly, Patrick, additional

Published
2021
Full Text
View/download PDF

86. First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study

Author

Tschopp, Jonathan, L’Huillier, Arnaud G., Mombelli, Matteo, Mueller, Nicolas J., Khanna, Nina, Garzoni, Christian, Meloni, Dario, Papadimitriou-Olivgeris, Matthaios, Neofytos, Dionysios, Hirsch, Hans H., Schuurmans, Macé M., Müller, Thomas, Berney, Thierry, Steiger, Jürg, Pascual, Manuel, Manuel, Oriol, and van Delden, Christian

Published
2020
Full Text
View/download PDF

87. Pulmonary function and radiological features four months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

Author

Guler, Sabina A., Ebner, Lukas, Beigelman, Catherine, Bridevaux, Pierre-Olivier, Brutsche, Martin, Clarenbach, Christian, Garzoni, Christian, Geiser, Thomas K., Lenoir, Alexandra, Mancinetti, Marco, Naccini, Bruno, Ott, Sebastian R., Piquilloud, Lise, Prella, Maura, Que, Yok-Ai, Soccal, Paula M., von Garnier, Christophe, and Funke-Chambour, Manuela

Subjects
610 Medicine & health
Published
2021
Full Text
View/download PDF

88. Impact of COVID-19 on Clinical Frailty Scale – a multicentre prospective cohort study

Author

Guler, Sabina A., primary, Müller, Ilena, additional, Mancinetti, Marco, additional, Bridevaux, Pierre-Olivier, additional, Brutsche, Marin, additional, Clarenbach, Christian, additional, Garzoni, Christian, additional, Lenoir, Alexandra, additional, Naccini, Bruno, additional, Ott, Sebastian R., additional, Piquilloud, Lise, additional, Prella, Maura, additional, Que, Yok-Ai, additional, Soccal, Paola, additional, Von Garner, Christophe, additional, Geiser, Thomas, additional, and Funke-Chambour, Manuela, additional

Published
2021
Full Text
View/download PDF

89. Broad betacoronavirus neutralization by a stem helix–specific human antibody

Author

Pinto, Dora, primary, Sauer, Maximilian M., additional, Czudnochowski, Nadine, additional, Low, Jun Siong, additional, Tortorici, M. Alejandra, additional, Housley, Michael P., additional, Noack, Julia, additional, Walls, Alexandra C., additional, Bowen, John E., additional, Guarino, Barbara, additional, Rosen, Laura E., additional, di Iulio, Julia, additional, Jerak, Josipa, additional, Kaiser, Hannah, additional, Islam, Saiful, additional, Jaconi, Stefano, additional, Sprugasci, Nicole, additional, Culap, Katja, additional, Abdelnabi, Rana, additional, Foo, Caroline, additional, Coelmont, Lotte, additional, Bartha, Istvan, additional, Bianchi, Siro, additional, Silacci-Fregni, Chiara, additional, Bassi, Jessica, additional, Marzi, Roberta, additional, Vetti, Eneida, additional, Cassotta, Antonino, additional, Ceschi, Alessandro, additional, Ferrari, Paolo, additional, Cippà, Pietro E., additional, Giannini, Olivier, additional, Ceruti, Samuele, additional, Garzoni, Christian, additional, Riva, Agostino, additional, Benigni, Fabio, additional, Cameroni, Elisabetta, additional, Piccoli, Luca, additional, Pizzuto, Matteo S., additional, Smithey, Megan, additional, Hong, David, additional, Telenti, Amalio, additional, Lempp, Florian A., additional, Neyts, Johan, additional, Havenar-Daughton, Colin, additional, Lanzavecchia, Antonio, additional, Sallusto, Federica, additional, Snell, Gyorgy, additional, Virgin, Herbert W., additional, Beltramello, Martina, additional, Corti, Davide, additional, and Veesler, David, additional

Published
2021
Full Text
View/download PDF

90. SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern

Author

McCallum, Matthew, primary, Bassi, Jessica, additional, De Marco, Anna, additional, Chen, Alex, additional, Walls, Alexandra C., additional, Di Iulio, Julia, additional, Tortorici, M. Alejandra, additional, Navarro, Mary-Jane, additional, Silacci-Fregni, Chiara, additional, Saliba, Christian, additional, Sprouse, Kaitlin R., additional, Agostini, Maria, additional, Pinto, Dora, additional, Culap, Katja, additional, Bianchi, Siro, additional, Jaconi, Stefano, additional, Cameroni, Elisabetta, additional, Bowen, John E., additional, Tilles, Sasha W., additional, Pizzuto, Matteo Samuele, additional, Guastalla, Sonja Bernasconi, additional, Bona, Giovanni, additional, Pellanda, Alessandra Franzetti, additional, Garzoni, Christian, additional, Van Voorhis, Wesley C., additional, Rosen, Laura E., additional, Snell, Gyorgy, additional, Telenti, Amalio, additional, Virgin, Herbert W., additional, Piccoli, Luca, additional, Corti, Davide, additional, and Veesler, David, additional

Published
2021
Full Text
View/download PDF

91. The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

Author

Thomson, Emma C., Rosen, Laura E., Shepherd, James G., Spreafico, Roberto, da Silva Filipe, Ana, Wojcechowskyj, Jason A., Davis, Chris, Piccoli, Luca, Pascall, David J., Dillen, Josh, Lytras, Spyros, Czudnochowski, Nadine, Shah, Rajiv, Meury, Marcel, Jesudason, Natasha, De Marco, Anna, Li, Kathy, Bassi, Jessica, O’Toole, Aine, Pinto, Dora, Colquhoun, Rachel M., Culap, Katja, Jackson, Ben, Zatta, Fabrizia, Rambaut, Andrew, Jaconi, Stefano, Sreenu, Vattipally B., Nix, Jay, Jarrett, Ruth F., Beltramello, Martina, Nomikou, Kyriaki, Pizzuto, Matteo, Tong, Lily, Cameroni, Elisabetta, Johnson, Natasha, Wickenhagen, Arthur, Ceschi, Alessandro, Mair, Daniel, Ferrari, Paolo, Smollett, Katherine, Sallusto, Federica, Carmichael, Stephen, Garzoni, Christian, Nichols, Jenna, Galli, Massimo, Hughes, Joseph, Riva, Agostino, Ho, Antonia, Semple, Malcolm G., Openshaw, Peter J.M., Baillie, J. Kenneth, Rihn, Suzannah J., Lycett, Samantha J., Virgin, Herbert W., Telenti, Amalio, Corti, Davide, Robertson, David L., Snell, Gyorgy, and Fadda, Elisa

Subjects
Immune system, biology, medicine.drug_class, Immunity, Polyclonal antibodies, biology.protein, medicine, Virulence, Antibody, Monoclonal antibody, Receptor, Virology, Virus
Abstract

SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is the most divergent region of S, and provide epidemiological, clinical, and molecular characterization of a prevalent RBM variant, N439K. We demonstrate that N439K S protein has enhanced binding affinity to the hACE2 receptor, and that N439K virus has similar clinical outcomes and in vitro replication fitness as compared to wild- type. We observed that the N439K mutation resulted in immune escape from a panel of neutralizing monoclonal antibodies, including one in clinical trials, as well as from polyclonal sera from a sizeable fraction of persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics.

Published
2020
Full Text
View/download PDF

92. Reduced mortality and shorten ICU stay in SARS-COV-2 pneumonia: a low PEEP strategy

Author

Ceruti, Samuele, Roncador, Marco, Gie, Olivier, Bona, Giovanni, Iattoni, Martina, Biggiogero, Maira, Maida, Pier Andrea, Garzoni, Christian, and Mauri, Romano

Subjects
respiratory system, circulatory and respiratory physiology, respiratory tract diseases
Abstract

Background Intensive Care Unit (ICU) management of COVID-19 patients with severe hypoxemia is associated with high mortality. We implemented a "care map", as a standardized multidisciplinary approach to improve patients monitoring using: uniform patient selection for ICU admission, a low-PEEP strategy and a pharmacologic strategic thromboembolism management. Methods A standardized protocol for managing COVID-19 patients and ICU admissions was implemented through accurate Early Warning Score (EWS) monitoring and thromboembolism prophylaxis at hospital admission. Dyspnea, mental confusion or SpO2 less than 85% were criteria for ICU admission. Ventilation approach employed low PEEP values (about 10 cmH2O in presence of lung compliance > 40 mL/cmH2O) and FiO2 as needed. In presence of lower lung compliance (< 40 mL/cmH2O) PEEP value was increased to about 14 cmH2O. Results From March 16th to April 12nd 2020, 41 COVID-19 patients were admitted to our ICU from a total of 310 patients. 83% (34) of them needed mechanical ventilation. The ventilation approach chosen employed low PEEP value based on BMI (PEEP 11+/- 3.8 (10-12) cmH2O if BMI < 30 Kg/m2; PEEP 15+/- 3.26 (12-18) cmH2O if BMI >30 Kg/m2). To date, ten patients (24%) died, four (9.7%) received mechanical ventilation, two were transferred to another hospital and 25 (60.9%) were discharged from ICU after a median of nine days. Discussion A multimodal approach for COVID-19 patients is mandatory. The knowledge of this multi-organ disease is growing rapidly, requiring improvements in the standard of care. Our approach implements an accurate pre-ICU monitoring and strict selection for ICU admission, and allows to reduce mechanical ventilation, ICU stay and mortality. Funding No funding has been required.

Published
2020
Full Text
View/download PDF

93. The Swiss Transplant Cohort Study: Lessons from the First 6Years

Author

Berger, Christoph, Bochud, Pierre-Yves, Boggian, Katja, Cusini, Alexia, Egli, Adrian, Garzoni, Christian, Hirsch, Hans, Hoffmann, Matthias, Khanna, Nina, Manuel, Oriol, Meylan, Pascal, Nadal, David, van Delden, Christian, Weisser, Maja, Mueller, Nicolas, Berger, Christoph, Bochud, Pierre-Yves, Boggian, Katja, Cusini, Alexia, Egli, Adrian, Garzoni, Christian, Hirsch, Hans, Hoffmann, Matthias, Khanna, Nina, Manuel, Oriol, Meylan, Pascal, Nadal, David, van Delden, Christian, Weisser, Maja, and Mueller, Nicolas

Abstract

Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95% of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96years (IQR 1.44-4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care.

Published
2021

94. Low PEEP Mechanical Ventilation and PaO 2/FiO 2 Ratio Evolution in COVID-19 Patients

Author

Ceruti, Samuele; https://orcid.org/0000-0003-4146-3434, Roncador, Marco, Saporito, Andrea, Biggiogero, Maira, Glotta, Andrea, Maida, Pier Andrea, Urso, Patrizia, Bona, Giovanni, Garzoni, Christian, Mauri, Romano, Borgeat, Alain, Ceruti, Samuele; https://orcid.org/0000-0003-4146-3434, Roncador, Marco, Saporito, Andrea, Biggiogero, Maira, Glotta, Andrea, Maida, Pier Andrea, Urso, Patrizia, Bona, Giovanni, Garzoni, Christian, Mauri, Romano, and Borgeat, Alain

Abstract

Invasive mechanical ventilation (IMV) is the standard treatment in critically ill COVID-19 patients with acute severe respiratory distress syndrome (ARDS). When IMV setting is extremely aggressive, especially through the application of high positive-end-expiratory respiration (PEEP) values, lung damage can occur. Until today, in COVID-19 patients, two types of ARDS were identified (L- and H-type); for the L-type, a lower PEEP strategy was supposed to be preferred, but data are still missing. The aim of this study was to evaluate if a clinical management with lower PEEP values in critically ill L-type COVID-19 patients was safe and efficient in comparison to usual standard of care. A retrospective analysis was conducted on consecutive patients with COVID-19 ARDS admitted to the ICU and treated with IMV. Patients were treated with a lower PEEP strategy adapted to BMI: PEEP 10 cmH2O if BMI < 30 kg m-2, PEEP 12 cmH2O if BMI 30-50 kg m-2, PEEP 15 cmH2O if BMI > 50 kg m-2. Primary endpoint was the PaO2/FiO2 ratio evolution during the first 3 IMV days; secondary endpoints were to analyze ICU length of stay (LOS) and IMV length. From March 2 to January 15, 2021, 79 patients underwent IMV. Average applied PEEP was 11 ± 2.9 cmH2O for BMI < 30 kg m-2 and 16 ± 3.18 cmH2O for BMI > 30 kg m-2. During the first 24 h of IMV, patients' PaO2/FiO2 ratio presented an improvement (p<0.001; CI 99%) that continued daily up to 72 h (p<0.001; CI 99%). Median ICU LOS was 15 days (10-28); median duration of IMV was 12 days (8-26). The ICU mortality rate was 31.6%. Lower PEEP strategy treatment in L-type COVID-19 ARDS resulted in a PaO2/FiO2 ratio persistent daily improvement during the first 72 h of IMV. A lower PEEP strategy could be beneficial in the first phase of ARDS in critically ill COVID-19 patients.

Published
2021

95. Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

Author

Guler, Sabina A; https://orcid.org/0000-0002-9833-5911, Ebner, Lukas, Aubry-Beigelman, Catherine, Bridevaux, Pierre-Olivier, Brutsche, Martin, Clarenbach, Christian; https://orcid.org/0000-0003-2158-2321, Garzoni, Christian, Geiser, Thomas K, Lenoir, Alexandra; https://orcid.org/0000-0003-2189-6507, Mancinetti, Marco, Naccini, Bruno, Ott, Sebastian R, Piquilloud, Lise, Prella, Maura, Que, Yok-Ai, Soccal, Paula M, von Garnier, Christophe, Funke-Chambour, Manuela; https://orcid.org/0000-0003-3417-5872, Guler, Sabina A; https://orcid.org/0000-0002-9833-5911, Ebner, Lukas, Aubry-Beigelman, Catherine, Bridevaux, Pierre-Olivier, Brutsche, Martin, Clarenbach, Christian; https://orcid.org/0000-0003-2158-2321, Garzoni, Christian, Geiser, Thomas K, Lenoir, Alexandra; https://orcid.org/0000-0003-2189-6507, Mancinetti, Marco, Naccini, Bruno, Ott, Sebastian R, Piquilloud, Lise, Prella, Maura, Que, Yok-Ai, Soccal, Paula M, von Garnier, Christophe, and Funke-Chambour, Manuela; https://orcid.org/0000-0003-3417-5872

Abstract

Background The infectious coronavirus disease 2019 (COVID-19) pandemic is an ongoing global healthcare challenge. Up to one-third of hospitalised patients develop severe pulmonary complications and acute respiratory distress syndrome. Pulmonary outcomes following COVID-19 are unknown. Methods The Swiss COVID-19 lung study is a multicentre prospective cohort investigating pulmonary sequelae of COVID-19. We report on initial follow-up 4 months after mild/moderate or severe/critical COVID-19 according to the World Health Organization severity classification. Results 113 COVID-19 survivors were included (mild/moderate n=47, severe/critical n=66). We confirmed several comorbidities as risk factors for severe/critical disease. Severe/critical disease was associated with impaired pulmonary function, i.e. diffusing capacity of the lung for carbon monoxide (DLCO) % predicted, reduced 6-min walk distance (6MWD) and exercise-induced oxygen desaturation. After adjustment for potential confounding by age, sex and body mass index (BMI), patients after severe/critical COVID-19 had a DLCO 20.9% pred (95% CI 12.4–29.4% pred, p=0.01) lower at follow-up. DLCO % pred was the strongest independent factor associated with previous severe/critical disease when age, sex, BMI, 6MWD and minimal peripheral oxygen saturation at exercise were included in the multivariable model (adjusted odds ratio per 10% predicted 0.59, 95% CI 0. 37–0.87; p=0.01). Mosaic hypoattenuation on chest computed tomography at follow-up was significantly associated with previous severe/critical COVID-19 including adjustment for age and sex (adjusted OR 11.7, 95% CI 1.7–239; p=0.03). Conclusions 4 months after severe acute respiratory syndrome coronavirus 2 infection, severe/critical COVID-19 was associated with significant functional and radiological abnormalities, potentially due to small-airway and lung parenchymal disease. A systematic follow-up for survivors needs to be evaluated to optimise care for patients recov

Published
2021

97. Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

Author

Low, Jun Siong, primary, Vaqueirinho, Daniela, additional, Mele, Federico, additional, Foglierini, Mathilde, additional, Jerak, Josipa, additional, Perotti, Michela, additional, Jarrossay, David, additional, Jovic, Sandra, additional, Perez, Laurent, additional, Cacciatore, Rosalia, additional, Terrot, Tatiana, additional, Pellanda, Alessandra Franzetti, additional, Biggiogero, Maira, additional, Garzoni, Christian, additional, Ferrari, Paolo, additional, Ceschi, Alessandro, additional, Lanzavecchia, Antonio, additional, Sallusto, Federica, additional, and Cassotta, Antonino, additional

Published
2021
Full Text
View/download PDF

99. SARS-CoV-2 immune evasion by variant B.1.427/B.1.429

Author

McCallum, Matthew, primary, Bassi, Jessica, additional, Marco, Anna De, additional, Chen, Alex, additional, Walls, Alexandra C., additional, Iulio, Julia Di, additional, Tortorici, M. Alejandra, additional, Navarro, Mary-Jane, additional, Silacci-Fregni, Chiara, additional, Saliba, Christian, additional, Agostini, Maria, additional, Pinto, Dora, additional, Culap, Katja, additional, Bianchi, Siro, additional, Jaconi, Stefano, additional, Cameroni, Elisabetta, additional, Bowen, John E., additional, Tilles, Sasha W, additional, Pizzuto, Matteo Samuele, additional, Guastalla, Sonja Bernasconi, additional, Bona, Giovanni, additional, Pellanda, Alessandra Franzetti, additional, Garzoni, Christian, additional, Van Voorhis, Wesley C., additional, Rosen, Laura E., additional, Snell, Gyorgy, additional, Telenti, Amalio, additional, Virgin, Herbert W., additional, Piccoli, Luca, additional, Corti, Davide, additional, and Veesler, David, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results