Search

Your search keyword '"Giordani B"' showing total 545 results
Start Over Author "Giordani B"
545 results on '"Giordani B"'

63. Cerebral metabolic differences in Parkinson's and Alzheimer's diseases matched for dementia severity.

Author

UCL - MD/MINT - Département de médecine interne, Vander Borght, Thierry, Minoshima, S., Giordani, B, Foster, N L, Frey, K A, Berent, S, Albin, R L, Koeppe, R A, Kuhl, D E, UCL - MD/MINT - Département de médecine interne, Vander Borght, Thierry, Minoshima, S., Giordani, B, Foster, N L, Frey, K A, Berent, S, Albin, R L, Koeppe, R A, and Kuhl, D E

Abstract

Despite controversial clinicopathological distinctions between Parkinson's disease with dementia (PDD) and Alzheimer's disease (AD), similar patterns of metabolic reduction in the posterior brain were reported previously using PET with [18F]fluorodeoxyglucose. The current study was designed to examine more specific regional differences in cerebral glucose metabolism between PDD and AD using accurate and objective brain mapping techniques. METHODS: This study included nine normal subjects, nine PDD patients and nine AD patients. PDD and AD groups were matched carefully for age, sex and general dementia severity as measured by Mini-Mental State Examination and Clinical Dementia Rating scales. Each subject underwent [18F]fluorodeoxyglucose-PET and neuropsychological testing. After anatomic standardization of PET image sets and stereotactic data extraction, absolute and normalized cerebral metabolic rates were assessed by region of interest and pixel-by-pixel analyses. RESULTS: PDD and AD showed global glucose metabolic reduction with similar regional accentuation involving the lateral parietal, lateral temporal and lateral frontal association cortices and posterior cingulate cortex in comparison to normal controls. When comparing between PDD and AD, however, PDD showed greater metabolic reduction in the visual cortex and relatively preserved metabolism in the medial temporal cortex. CONCLUSION: Although a common feature of metabolic abnormalities in the posterior brain exists in PDD and AD, the presence of regional metabolic differences suggests different degrees and combinations of disease specific underlying pathological and neurochemical processes.

Published
1997

86. Developing a positive emotion-motivated tai chi (PEM-TC) exercise program for older adults with dementia.

Author

Yao L, Giordani B, and Alexander NB

Abstract

Exercise, particularly Tai Chi, has many known benefits, especially in reducing fall risk. However, exercise studies have tended to exclude older adults with dementia (OAD), who may be at high fall risk but have difficulty participating in formal exercise programs. This paper describes development and feasibility testing of a Tai Chi fall risk reduction exercise protocol, the positive emotion-motivated Tai Chi (PEM-TC) program for OAD, and explores strategies that facilitate their participation in and adherence to exercise programs. Preliminary data indicates that difficulties in delivering exercise to OAD may be eased by using the Sticky Hands Tai Chi teachingtechnique. Family members may have the optimum advantage in using Sticky Hands because of established emotional connections with their OAD. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results