Search

Your search keyword '"Gleave, Martin E."' showing total 1,658 results
Start Over Author "Gleave, Martin E."
1,658 results on '"Gleave, Martin E."'

53. Abstract B048: Performance of diagnostic biomarkers in the Canary Prostate cancer Active Surveillance Study (PASS)

Author

Newcomb, Lisa F., primary, Zheng, Yingye, additional, Liu, Menghan, additional, Brooks, James D., additional, Carroll, Peter R., additional, Dash, Atreya, additional, Ellis, William J., additional, Filson, Christopher J., additional, Gleave, Martin E., additional, Liss, Michael A., additional, Martin, Frances M., additional, Morgan, Todd M., additional, Nelson, Peter S., additional, Wagner, Andrew A., additional, and Lin, Daniel W., additional

Published
2023
Full Text
View/download PDF

55. ABI1 regulates transcriptional activity of Androgen Receptor by novel DNA and AR binding mechanism

Author

Porter, Baylee A., primary, Li, Xiang, additional, Arya, Neeru, additional, Zhang, Fan, additional, Kung, Sonia H.Y., additional, Fazli, Ladan, additional, Zarni Oo, Htoo, additional, Li, Yinan, additional, Marincin, Kenneth, additional, Kukkonen, Konsta, additional, Urhonen, Henna, additional, Ortiz, Maria A., additional, Kemraj, Allysa P., additional, Corey, Eva, additional, Dong, Xuesen, additional, Kuznetsov, Vladimir A., additional, Nykter, Matti, additional, Gleave, Martin E., additional, Bratslavsky, Gennady, additional, Urbanucci, Alfonso, additional, Frueh, Dominique, additional, Bah, Alaji, additional, and Kotula, Leszek, additional

Published
2023
Full Text
View/download PDF

56. Clonality Inference from Single Tumor Samples Using Low Coverage Sequence Data

Author

Donmez, Nilgun, Malikic, Salem, Wyatt, Alexander W., Gleave, Martin E., Collins, Colin C., Sahinalp, S. Cenk, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Josef, Kittler, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, and Singh, Mona, editor

Published
2016
Full Text
View/download PDF

58. Molecular features of prostate cancer after neoadjuvant therapy in the phase 3 CALGB 90203 trial.

Author

Sumiyoshi, Takayuki, Wang, Xiaofei, Warner, Evan W, Sboner, Andrea, Annala, Matti, Sigouros, Michael, Beja, Kevin, Mizuno, Kei, Ku, Shengyu, Fazli, Ladan, Eastham, James, Taplin, Mary-Ellen, Simko, Jeffrey, Halabi, Susan, Morris, Michael J, Gleave, Martin E, Wyatt, Alexander W, and Beltran, Himisha

Subjects
PROSTATE cancer, GENE expression, NEOADJUVANT chemotherapy, RADICAL prostatectomy, ANDROGEN deprivation therapy, DNA sequencing
Abstract

Background The phase 3 CALGB 90203 (Alliance) trial evaluated neoadjuvant chemohormonal therapy for high-risk localized prostate cancer before radical prostatectomy. We dissected the molecular features of post-treated tumors with long-term clinical outcomes to explore mechanisms of response and resistance to chemohormonal therapy. Methods We evaluated 471 radical prostatectomy tumors, including 294 samples from 166 patients treated with 6 cycles of docetaxel plus androgen deprivation therapy before radical prostatectomy and 177 samples from 97 patients in the control arm (radical prostatectomy alone). Targeted DNA sequencing and RNA expression of tumor foci and adjacent noncancer regions were analyzed in conjunction with pathologic changes and clinical outcomes. Results Tumor fraction estimated from DNA sequencing was significantly lower in post-treated tumor tissues after chemohormonal therapy compared with controls. Higher tumor fraction after chemohormonal therapy was associated with aggressive pathologic features and poor outcomes, including prostate-specific antigen–progression-free survival. SPOP alterations were infrequently detected after chemohormonal therapy, while TP53 alterations were enriched and associated with shorter overall survival. Residual tumor fraction after chemohormonal therapy was linked to higher expression of androgen receptor–regulated genes, cell cycle genes, and neuroendocrine genes, suggesting persistent populations of active prostate cancer cells. Supervised clustering of post–treated high-tumor-fraction tissues identified a group of patients with elevated cell cycle–related gene expression and poor clinical outcomes.  Conclusions Distinct recurrent prostate cancer genomic and transcriptomic features are observed after exposure to docetaxel and androgen deprivation therapy. Tumor fraction assessed by DNA sequencing quantifies pathologic response and could be a useful trial endpoint or prognostic biomarker. TP53 alterations and high cell cycle transcriptomic activity are linked to aggressive residual disease, despite potent chemohormonal therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

60. SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1

Author

Peacock, James W, Takeuchi, Ario, Hayashi, Norihiro, Liu, Liangliang, Tam, Kevin J, Al Nakouzi, Nader, Khazamipour, Nastaran, Tombe, Tabitha, Dejima, Takashi, Lee, Kevin CK, Shiota, Masaki, Thaper, Daksh, Lee, Wilson CW, Hui, Daniel HF, Kuruma, Hidetoshi, Ivanova, Larissa, Yenki, Parvin, Jiao, Ivy ZF, Khosravi, Shahram, Mui, Alice L‐F, Fazli, Ladan, Zoubeidi, Amina, Daugaard, Mads, Gleave, Martin E, and Ong, Christopher J

Published
2018
Full Text
View/download PDF

63. Supplementary Figure 1 from Transcription Factor Stat5 Knockdown Enhances Androgen Receptor Degradation and Delays Castration-Resistant Prostate Cancer Progression In vivo

Author

Thomas, Christian, primary, Zoubeidi, Amina, primary, Kuruma, Hidetoshi, primary, Fazli, Ladan, primary, Lamoureux, Francois, primary, Beraldi, Eliana, primary, Monia, Brett P., primary, MacLeod, A. Robert, primary, Thüroff, Joachim W., primary, and Gleave, Martin E., primary

Published
2023
Full Text
View/download PDF

64. Data from Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity

Author

Aggarwal, Rahul R., primary, Quigley, David A., primary, Huang, Jiaoti, primary, Zhang, Li, primary, Beer, Tomasz M., primary, Rettig, Matthew B., primary, Reiter, Rob E., primary, Gleave, Martin E., primary, Thomas, George V., primary, Foye, Adam, primary, Playdle, Denise, primary, Lloyd, Paul, primary, Chi, Kim N., primary, Evans, Christopher P., primary, Lara, Primo N., primary, Feng, Felix Y., primary, Alumkal, Joshi J., primary, and Small, Eric J., primary

Published
2023
Full Text
View/download PDF

65. Data from Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer

Author

Annala, Matti, primary, Vandekerkhove, Gillian, primary, Khalaf, Daniel, primary, Taavitsainen, Sinja, primary, Beja, Kevin, primary, Warner, Evan W., primary, Sunderland, Katherine, primary, Kollmannsberger, Christian, primary, Eigl, Bernhard J., primary, Finch, Daygen, primary, Oja, Conrad D., primary, Vergidis, Joanna, primary, Zulfiqar, Muhammad, primary, Azad, Arun A., primary, Nykter, Matti, primary, Gleave, Martin E., primary, Wyatt, Alexander W., primary, and Chi, Kim N., primary

Published
2023
Full Text
View/download PDF

66. Figure S1 from Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer

Author

Kawai, Yoshihisa, primary, Imada, Kenjiro, primary, Akamatsu, Shusuke, primary, Zhang, Fan, primary, Seiler, Roland, primary, Hayashi, Tetsutaro, primary, Leong, Jeffrey, primary, Beraldi, Eliana, primary, Saxena, Neetu, primary, Kretschmer, Alexander, primary, Oo, Htoo Zarni, primary, Contreras-Sanz, Alberto, primary, Matsuyama, Hideyasu, primary, Lin, Dong, primary, Fazli, Ladan, primary, Collins, Colin C., primary, Wyatt, Alexander W., primary, Black, Peter C., primary, and Gleave, Martin E., primary

Published
2023
Full Text
View/download PDF

67. Data from Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor–Chromatin Interactions

Author

Dalal, Kush, primary, Che, Meixia, primary, Que, Nanette S., primary, Sharma, Aishwariya, primary, Yang, Rendong, primary, Lallous, Nada, primary, Borgmann, Hendrik, primary, Ozistanbullu, Deniz, primary, Tse, Ronnie, primary, Ban, Fuqiang, primary, Li, Huifang, primary, Tam, Kevin J., primary, Roshan-Moniri, Mani, primary, LeBlanc, Eric, primary, Gleave, Martin E., primary, Gewirth, Daniel T., primary, Dehm, Scott M., primary, Cherkasov, Artem, primary, and Rennie, Paul S., primary

Published
2023
Full Text
View/download PDF

69. Supplementary Table 2 from Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity

Author

Aggarwal, Rahul R., primary, Quigley, David A., primary, Huang, Jiaoti, primary, Zhang, Li, primary, Beer, Tomasz M., primary, Rettig, Matthew B., primary, Reiter, Rob E., primary, Gleave, Martin E., primary, Thomas, George V., primary, Foye, Adam, primary, Playdle, Denise, primary, Lloyd, Paul, primary, Chi, Kim N., primary, Evans, Christopher P., primary, Lara, Primo N., primary, Feng, Felix Y., primary, Alumkal, Joshi J., primary, and Small, Eric J., primary

Published
2023
Full Text
View/download PDF

72. Supplementary Table 3 from Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

Author

Beltran, Himisha, primary, Rickman, David S., primary, Park, Kyung, primary, Chae, Sung Suk, primary, Sboner, Andrea, primary, MacDonald, Theresa Y., primary, Wang, Yuwei, primary, Sheikh, Karen L., primary, Terry, Stéphane, primary, Tagawa, Scott T., primary, Dhir, Rajiv, primary, Nelson, Joel B., primary, de la Taille, Alexandre, primary, Allory, Yves, primary, Gerstein, Mark B., primary, Perner, Sven, primary, Pienta, Kenneth J., primary, Chinnaiyan, Arul M., primary, Wang, Yuzhuo, primary, Collins, Colin C., primary, Gleave, Martin E., primary, Demichelis, Francesca, primary, Nanus, David M., primary, and Rubin, Mark A., primary

Published
2023
Full Text
View/download PDF

73. Supplementary Information from Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer

Author

Kawai, Yoshihisa, primary, Imada, Kenjiro, primary, Akamatsu, Shusuke, primary, Zhang, Fan, primary, Seiler, Roland, primary, Hayashi, Tetsutaro, primary, Leong, Jeffrey, primary, Beraldi, Eliana, primary, Saxena, Neetu, primary, Kretschmer, Alexander, primary, Oo, Htoo Zarni, primary, Contreras-Sanz, Alberto, primary, Matsuyama, Hideyasu, primary, Lin, Dong, primary, Fazli, Ladan, primary, Collins, Colin C., primary, Wyatt, Alexander W., primary, Black, Peter C., primary, and Gleave, Martin E., primary

Published
2023
Full Text
View/download PDF

74. Data from The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

Author

Bishop, Jennifer L., primary, Thaper, Daksh, primary, Vahid, Sepideh, primary, Davies, Alastair, primary, Ketola, Kirsi, primary, Kuruma, Hidetoshi, primary, Jama, Randy, primary, Nip, Ka Mun, primary, Angeles, Arkhjamil, primary, Johnson, Fraser, primary, Wyatt, Alexander W., primary, Fazli, Ladan, primary, Gleave, Martin E., primary, Lin, Dong, primary, Rubin, Mark A., primary, Collins, Colin C., primary, Wang, Yuzhuo, primary, Beltran, Himisha, primary, and Zoubeidi, Amina, primary

Published
2023
Full Text
View/download PDF

76. Supplementary Table S2 from The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

Author

Bishop, Jennifer L., primary, Thaper, Daksh, primary, Vahid, Sepideh, primary, Davies, Alastair, primary, Ketola, Kirsi, primary, Kuruma, Hidetoshi, primary, Jama, Randy, primary, Nip, Ka Mun, primary, Angeles, Arkhjamil, primary, Johnson, Fraser, primary, Wyatt, Alexander W., primary, Fazli, Ladan, primary, Gleave, Martin E., primary, Lin, Dong, primary, Rubin, Mark A., primary, Collins, Colin C., primary, Wang, Yuzhuo, primary, Beltran, Himisha, primary, and Zoubeidi, Amina, primary

Published
2023
Full Text
View/download PDF

78. Supplementary Table S1 from Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer

Author

Kawai, Yoshihisa, primary, Imada, Kenjiro, primary, Akamatsu, Shusuke, primary, Zhang, Fan, primary, Seiler, Roland, primary, Hayashi, Tetsutaro, primary, Leong, Jeffrey, primary, Beraldi, Eliana, primary, Saxena, Neetu, primary, Kretschmer, Alexander, primary, Oo, Htoo Zarni, primary, Contreras-Sanz, Alberto, primary, Matsuyama, Hideyasu, primary, Lin, Dong, primary, Fazli, Ladan, primary, Collins, Colin C., primary, Wyatt, Alexander W., primary, Black, Peter C., primary, and Gleave, Martin E., primary

Published
2023
Full Text
View/download PDF

79. Supplementary Figure 1 from Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity

Author

Aggarwal, Rahul R., primary, Quigley, David A., primary, Huang, Jiaoti, primary, Zhang, Li, primary, Beer, Tomasz M., primary, Rettig, Matthew B., primary, Reiter, Rob E., primary, Gleave, Martin E., primary, Thomas, George V., primary, Foye, Adam, primary, Playdle, Denise, primary, Lloyd, Paul, primary, Chi, Kim N., primary, Evans, Christopher P., primary, Lara, Primo N., primary, Feng, Felix Y., primary, Alumkal, Joshi J., primary, and Small, Eric J., primary

Published
2023
Full Text
View/download PDF

83. Supplementary Table 1 from Whole-Genome and Transcriptional Analysis of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer Demonstrates Intraclass Heterogeneity

Author

Aggarwal, Rahul R., primary, Quigley, David A., primary, Huang, Jiaoti, primary, Zhang, Li, primary, Beer, Tomasz M., primary, Rettig, Matthew B., primary, Reiter, Rob E., primary, Gleave, Martin E., primary, Thomas, George V., primary, Foye, Adam, primary, Playdle, Denise, primary, Lloyd, Paul, primary, Chi, Kim N., primary, Evans, Christopher P., primary, Lara, Primo N., primary, Feng, Felix Y., primary, Alumkal, Joshi J., primary, and Small, Eric J., primary

Published
2023
Full Text
View/download PDF

84. Data from Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

Author

Beltran, Himisha, primary, Rickman, David S., primary, Park, Kyung, primary, Chae, Sung Suk, primary, Sboner, Andrea, primary, MacDonald, Theresa Y., primary, Wang, Yuwei, primary, Sheikh, Karen L., primary, Terry, Stéphane, primary, Tagawa, Scott T., primary, Dhir, Rajiv, primary, Nelson, Joel B., primary, de la Taille, Alexandre, primary, Allory, Yves, primary, Gerstein, Mark B., primary, Perner, Sven, primary, Pienta, Kenneth J., primary, Chinnaiyan, Arul M., primary, Wang, Yuzhuo, primary, Collins, Colin C., primary, Gleave, Martin E., primary, Demichelis, Francesca, primary, Nanus, David M., primary, and Rubin, Mark A., primary

Published
2023
Full Text
View/download PDF

89. Tables S1-S9 from Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer

Author

Annala, Matti, primary, Vandekerkhove, Gillian, primary, Khalaf, Daniel, primary, Taavitsainen, Sinja, primary, Beja, Kevin, primary, Warner, Evan W., primary, Sunderland, Katherine, primary, Kollmannsberger, Christian, primary, Eigl, Bernhard J., primary, Finch, Daygen, primary, Oja, Conrad D., primary, Vergidis, Joanna, primary, Zulfiqar, Muhammad, primary, Azad, Arun A., primary, Nykter, Matti, primary, Gleave, Martin E., primary, Wyatt, Alexander W., primary, and Chi, Kim N., primary

Published
2023
Full Text
View/download PDF

95. Supplementary Figure S1 - S8 from The Master Neural Transcription Factor BRN2 Is an Androgen Receptor–Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer

Author

Bishop, Jennifer L., primary, Thaper, Daksh, primary, Vahid, Sepideh, primary, Davies, Alastair, primary, Ketola, Kirsi, primary, Kuruma, Hidetoshi, primary, Jama, Randy, primary, Nip, Ka Mun, primary, Angeles, Arkhjamil, primary, Johnson, Fraser, primary, Wyatt, Alexander W., primary, Fazli, Ladan, primary, Gleave, Martin E., primary, Lin, Dong, primary, Rubin, Mark A., primary, Collins, Colin C., primary, Wang, Yuzhuo, primary, Beltran, Himisha, primary, and Zoubeidi, Amina, primary

Published
2023
Full Text
View/download PDF

96. Supplementary Figures 1-15, Supplementary Tables 1-2, Supplementary Methods from Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets

Author

Beltran, Himisha, primary, Rickman, David S., primary, Park, Kyung, primary, Chae, Sung Suk, primary, Sboner, Andrea, primary, MacDonald, Theresa Y., primary, Wang, Yuwei, primary, Sheikh, Karen L., primary, Terry, Stéphane, primary, Tagawa, Scott T., primary, Dhir, Rajiv, primary, Nelson, Joel B., primary, de la Taille, Alexandre, primary, Allory, Yves, primary, Gerstein, Mark B., primary, Perner, Sven, primary, Pienta, Kenneth J., primary, Chinnaiyan, Arul M., primary, Wang, Yuzhuo, primary, Collins, Colin C., primary, Gleave, Martin E., primary, Demichelis, Francesca, primary, Nanus, David M., primary, and Rubin, Mark A., primary

Published
2023
Full Text
View/download PDF

100. SupplementaryTable S2 from Paternally Expressed Gene 10 (PEG10) Promotes Growth, Invasion, and Survival of Bladder Cancer

Author

Kawai, Yoshihisa, primary, Imada, Kenjiro, primary, Akamatsu, Shusuke, primary, Zhang, Fan, primary, Seiler, Roland, primary, Hayashi, Tetsutaro, primary, Leong, Jeffrey, primary, Beraldi, Eliana, primary, Saxena, Neetu, primary, Kretschmer, Alexander, primary, Oo, Htoo Zarni, primary, Contreras-Sanz, Alberto, primary, Matsuyama, Hideyasu, primary, Lin, Dong, primary, Fazli, Ladan, primary, Collins, Colin C., primary, Wyatt, Alexander W., primary, Black, Peter C., primary, and Gleave, Martin E., primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results