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51. An eHealth decision‐support tool to prioritize referral practices for genetic evaluation of patients with Wilms tumor

Author

Cullinan, Noelle, primary, Villani, Anita, additional, Mourad, Stephanie, additional, Somers, Gino R., additional, Reichman, Lara, additional, Engelen, Kalene, additional, Stephens, Derek, additional, Weksberg, Rosanna, additional, Foulkes, William D., additional, Malkin, David, additional, Grant, Ronald, additional, and Goudie, Catherine, additional

Published
2019
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55. DICER1 screening in 15 paediatric paratesticular sarcomas unveils an unusual DICER1‐associated sarcoma.

Author

Apellaniz‐Ruiz, Maria, Cullinan, Noelle, Grant, Ronald, Marrano, Paula, Priest, John R, Thorner, Paul S, Goudie, Catherine, and Foulkes, William D

Subjects
SARCOMA, GENETIC disorders, FAMILY history (Medicine), SOMATIC mutation, APPENDIX (Anatomy)
Abstract

Individuals with DICER1 syndrome, a genetic disorder caused by pathogenic germline variants in DICER1, are at increased risk of developing a wide array of predominantly childhood onset conditions, including genitourinary sarcomas. However, data on DICER1 involvement in paratesticular sarcomas have not been published. Herein, we analyse a series of 15 paediatric paratesticular sarcomas and describe in detail the case of a male infant with a paratesticular myxoid tumour, considered to be a low‐grade sarcoma, who also manifested a cystic nephroma, a classic DICER1 syndrome phenotype. He harboured a pathogenic germline DICER1 variant and different somatic hot‐spot mutations in each tumour. The paratesticular tumour showed strong and diffuse expression for WT1 and CD10, an unusual immunophenotype in paediatric sarcomas, but typical of tumours of Müllerian origin. The tumour was postulated to arise from the appendix testis, a Müllerian remnant located in the paratestis. Such an origin would be analogous to other DICER1‐associated non‐epithelial gynaecological tumours, thought to arise from Müllerian derivatives. These findings point towards a key role of DICER1 in Müllerian‐derived structures. Supporting this hypothesis is the fact that the other paratesticular sarcomas from the series were either negative or focally positive for WT1 and for CD10, and none had any DICER1 mutations. In summary, we present the first case of a paratesticular sarcoma associated with DICER1 syndrome, emphasising that paratesticular tumours with an unusual histological appearance may suggest an underlying DICER1 mutation, especially in the presence of a personal or family history of DICER1‐associated disease. In this context, DICER1 mutation testing could lead to changes in clinical care including implementation of cancer care surveillance strategies. [ABSTRACT FROM AUTHOR]

Published
2020
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56. ATRT-40. IMPACT OF MOLECULAR SUBTYPES ON TREATMENT OUTCOMES IN RHABDOID TUMORS - A REPORT FROM THE RARE TUMOR CONSORTIUM

Author

Ho, Ben, primary, Fonseca, Adriana, additional, Al-Karmi, Salma, additional, Margol, Ashley, additional, Yao, Fupan, additional, Cheng, Sylvia, additional, Grant, Ronald, additional, Handsford, Jordan, additional, Gupta, Abha, additional, Vasiljevic, Alexandre, additional, Pawel, Bruce, additional, Jabado, Nada, additional, Hawkins, Cynthia, additional, Lafay-Cousin, Lucie, additional, Judkins, Alexander, additional, Bouffet, Eric, additional, and Huang, Annie, additional

Published
2018
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57. TBIO-30. MOLECULAR LANDSCAPE AND CLINICAL CORRELATIONS OF CNS SARCOMAS

Author

Fonseca, Adriana, primary, Ho, Ben, additional, Torchia, Jonathon, additional, Leary, Sarah, additional, Lu, Mei, additional, Sommers, Gino, additional, Gupta, Abha, additional, Grant, Ronald, additional, Norman, Joe, additional, Lafay-Cousin, Lucie, additional, Hawkins, Cynthia, additional, Bartels, Ute, additional, Bouffet, Eric, additional, and Huang, Annie, additional

Published
2018
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58. WHY EDUCATION? AN EXAMINATION OF WHY LATINOS/HISPANICS PURSUE A CAREER AS TEACHERS

Author

Grant, Ronald Jr

Subjects
Hispanic educators, Latino educators, LatCrit, Oklahoma City metro area teachers, representation
Abstract

Supported by research on urban education, teacher shortages, and ethnic representation, this qualitative case study seeks to explore the motivations behind Hispanics and/or Latinos pursuing careers in education and the paths they take to achieve this objective. Conducted through semi-structured virtual interviews with ten current educators in the Oklahoma City metro area, the study employs Critical Race Theory and Latino Critical Race Theory to analyze their lived experiences. From these interviews, five key themes emerged: adverse high school experiences, lack of college knowledge, financial obstacles, language barriers, and strong connections with students. These findings illuminate the hurdles encountered by Hispanic and/or Latino individuals in the education field, emphasizing the necessity for systemic support and representation. The insights gleaned from this research provide valuable direction for educational institutions and policymakers, offering strategies to overcome barriers and foster a more inclusive environment. By prioritizing diversity and representation, the goal is to inspire and empower more Hispanics and/or Latinos to pursue careers in education, thereby enhancing the profession and benefiting students and communities alike.

Published
2024

61. DICER1 syndrome: Approach to testing and management at a large pediatric tertiary care center

Author

van Engelen, Kalene, primary, Villani, Anita, additional, Wasserman, Jonathan D., additional, Aronoff, Laura, additional, Greer, Mary-Louise C., additional, Tijerin Bueno, Marta, additional, Gallinger, Bailey, additional, Kim, Raymond H., additional, Grant, Ronald, additional, Meyn, M. Stephen, additional, Malkin, David, additional, and Druker, Harriet, additional

Published
2017
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62. Wilms tumour in Beckwith–Wiedemann Syndrome and loss of methylation at imprinting centre 2: revisiting tumour surveillance guidelines

Author

Brzezinski, Jack, primary, Shuman, Cheryl, additional, Choufani, Sanaa, additional, Ray, Peter, additional, Stavropoulos, Dmitiri J, additional, Basran, Raveen, additional, Steele, Leslie, additional, Parkinson, Nicole, additional, Grant, Ronald, additional, Thorner, Paul, additional, Lorenzo, Armando, additional, and Weksberg, Rosanna, additional

Published
2017
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63. An eHealth decision‐support tool to prioritize referral practices for genetic evaluation of patients with Wilms tumor.

Author

Cullinan, Noelle, Villani, Anita, Mourad, Stephanie, Somers, Gino R., Reichman, Lara, Engelen, Kalene, Stephens, Derek, Weksberg, Rosanna, Foulkes, William D., Malkin, David, Grant, Ronald, and Goudie, Catherine

Subjects
NEPHROBLASTOMA, CONGENITAL disorders, TUMORS in children, GENETIC counseling, MEDICAL care, HEREDITARY cancer syndromes
Abstract

Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). Cognizant of increasing demand for genetic evaluation and limited resources across health care settings, there is an urgent need to rationalize genetic referrals for this population. The McGill Interactive Pediatric OncoGenetic Guidelines study, a Canadian multi‐institutional initiative, aims to develop an eHealth tool to assist physicians in identifying children at elevated risk of having a CPS. As part of this project, a decisional algorithm specific to WT consisting of five tumor‐specific criteria (age <2 years, bilaterality/multifocality, stromal‐predominant histology, nephrogenic rests, and overgrowth features) and universal criteria including features of family history suspicious for CPS and congenital anomalies, was developed. Application of the algorithm generates a binary recommendation—for or against genetic referral for CPS evaluation. To evaluate the algorithm's sensitivity for CPS identification, we retrospectively applied the tool in consecutive pediatric patients (n = 180) with WT, diagnosed and/or treated at The Hospital for Sick Children (1997–2016). Odds ratios were calculated to evaluate the strengths of associations between each criterion and specific CPS subtypes. Application of the algorithm identified 100% of children with WT and a confirmed CPS (n = 27). Age <2 years, bilaterality/multifocality, and congenital anomalies were strongly associated with pathogenic variants in WT1. Presence of >1 overgrowth feature was strongly associated with Beckwith‐Wiedemann syndrome. Stromal‐predominant histology did not contribute to CPS identification. We recommend the incorporation of the WT algorithm in the routine assessment of children with WT to facilitate prioritization of genetic referrals in a sustainable manner. What's new? Over 10% of children with Wilms tumor (WT) have an underlying cancer predisposition syndrome (CPS). CPS recognition can lead to immediate changes in first line cancer therapy, implementation of surveillance strategies, and genetic counselling of family members. Here, as part of the MIPOGG (McGill Interactive Pediatric OncoGenetic Guidelines) study, the authors report the effectiveness of a novel, easy‐to‐use eHealth decision‐support tool in identifying those patients diagnosed with WT who are at highest likelihood of having an underlying CPS. These findings provide a systematic approach for pediatric oncologists worldwide to rationalize genetic referral practices and genetic testing for children with Wilms tumor. [ABSTRACT FROM AUTHOR]

Published
2020
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64. NUT midline carcinoma of the larynx: an international series and review of the literature

Author

Hellquist, Henrik, primary, French, Christopher A, additional, Bishop, Justin A, additional, Coca-Pelaz, Andrés, additional, Propst, Evan J, additional, Paiva Correia, António, additional, Ngan, Bo-Yee, additional, Grant, Ronald, additional, Cipriani, Nicole A, additional, Vokes, David, additional, Henrique, Rui, additional, Pardal, Fernando, additional, Vizcaino, Jose Ramon, additional, Rinaldo, Alessandra, additional, and Ferlito, Alfio, additional

Published
2017
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66. Bone Morbidity and Recovery in Children With Acute Lymphoblastic Leukemia: Results of a Six‐Year Prospective Cohort Study.

Author

Ward, Leanne M., Ma, Jinhui, Lang, Bianca, Ho, Josephine, Alos, Nathalie, Matzinger, Mary Ann, Shenouda, Nazih, Lentle, Brian, Jaremko, Jacob L., Wilson, Beverly, Stephure, David, Stein, Robert, Sbrocchi, Anne Marie, Rodd, Celia, Lewis, Victor, Israels, Sara, Grant, Ronald M., Fernandez, Conrad V., Dix, David B., and Cummings, Elizabeth A.

Abstract

ABSTRACT: Osteoporotic fractures are a significant cause of morbidity in acute lymphoblastic leukemia (ALL). Our objective was to determine the incidence and predictors of fractures and recovery from osteoporosis in pediatric ALL over 6 years following glucocorticoid initiation. Vertebral fractures (VF) and vertebral body reshaping were assessed on annual spine radiographs, low‐trauma non‐VF were recorded at regular intervals and spine bone mineral density (BMD) was captured every 6 months for 4 years and then annually. A total of 186 children with ALL were enrolled (median age 5.3 years; range, 1.3 to 17.0 years). The cumulative fracture incidence was 32.5% for VF and 23.0% for non‐VF; 39.0% of children with VF were asymptomatic. No fractures occurred in the sixth year and 71.3% of incident fractures occurred in the first 2 years. Baseline VF, cumulative glucocorticoid dose, and baseline lumbar spine (LS) BMD Z‐score predicted both VF and non‐VF. Vertebral body reshaping following VF was incomplete or absent in 22.7% of children. Those with residual vertebral deformity following VF were older compared to those without (median age 8.0 years at baseline [interquartile range {IQR}, 5.5 to 9.4] versus 4.8 years [IQR, 3.6 to 6.2], p = 0.04) and had more severe vertebral collapse (median maximum spinal deformity index 3.5 [IQR, 1.0 to 8.0] versus 0.5 [IQR, 0.0 to 1.0], p = 0.01). VF and low LS BMD Z‐score at baseline as well as glucocorticoid exposure predicted incident VF and non‐VF. Nearly 25% of children had persistent vertebral deformity following VF, more frequent in older children, and in those with more severe collapse. These results suggest the need for trials addressing interventions in the first 2 years of chemotherapy, targeting older children and children with more severe vertebral collapse, because these children are at greatest risk for incident VF and subsequent residual vertebral deformity. © 2018 American Society for Bone and Mineral Research. [ABSTRACT FROM AUTHOR]

Published
2018
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67. Quick Start Guide to Oracle Fusion Development : Oracle JDeveloper and Oracle ADF

Author

Grant Ronald and Grant Ronald

Subjects
Business--Data processing, Internet programming, Web services, Application software--Development
Abstract

Get Started with Oracle Fusion Development Written by a Group Product Manager at Oracle, this Oracle Press guide gets you up and running quickly with your first Oracle Fusion applications. Quick Start Guide to Oracle Fusion Development provides only the essential information you need to build applications in a matter of hours. Rapidly learn the building blocks and functionality you'll use most of the time. The progression of topics closely matches the application building process, taking you through a typical developer scenario from start to completion. Quick Start Guide to Oracle Fusion Development features Concise and friendly format providing the essentials needed to start building applications right away Chapters that build on each other to illustrate a typical development scenario from start to finish Unique author insights gained from hours of one-on-one meetings with customers and work in Oracle's usability labs The perfect entry point to Oracle Fusion development Introduction to Fusion and the Fusion Technologies; Introduction to JDeveloper and Oracle ADF; Finding your Way Around JDeveloper; Building Business Services; Introducing ADF Business Components; The Role of the Entity; A View of your Data – The View Object; The Application Module; Implementing Business Service Validation; More View Object Features; Building the User Interface; Introducing ADF Face Rich Client; ADF Model; Building Typical ADF Pages; Building Application Flow; Menus, Toolbars and Buttons; Advanced UI Techniques; Data Visualization and Other Rich UI Components; Application Look and Feel; Common Coding Patterns; Common Business Service Coding Examples; Common View Coding Examples

Published
2011

68. Abstract B09: DNA polymerase mutations trigger rapid onset of ultra-hypermutant malignant brain tumors in children with biallelic mismatch repair deficiency

Author

Shlien, Adam, primary, Campbell, Brittany B., additional, Borja, Richard de, additional, Alexandrov, Ludmil B., additional, Merico, Daniele, additional, Wedge, David, additional, Loo, Peter Van, additional, Tarpey, Patrick S., additional, Coupland, Paul, additional, Pollett, Aaron, additional, Lipman, Tatiana, additional, Heidari, Abolfazl, additional, Deshmukh, Shriya, additional, Gerstung, Moritz, additional, Merino, Diana, additional, Ramakrishna, Manasa, additional, Remke, Marc, additional, Arnold, Roland, additional, Panigrahi, Gagan B., additional, Afzal, Samina, additional, Larouche, Valerie, additional, Druker, Harriet, additional, Lerner-Ellis, Jordan, additional, Mistry, Matthew, additional, Dvir, Rina, additional, Grant, Ronald, additional, Elhasid, Ronit, additional, Farah, Roula, additional, Taylor, Glenn P., additional, Nathan, Paul C., additional, Alexander, Sarah, additional, Ben-Shachar, Shay, additional, Jabado, Nada, additional, Gallinger, Steven, additional, Constantini, Shlohmi, additional, Dirks, Peter, additional, Huang, Annie, additional, Scherer, Steven W., additional, Grundy, Richard G., additional, Durno, Carol, additional, Aronson, Melyssa, additional, Meyn, M Stephen, additional, Taylor, Michael D., additional, Pursell, Zachary F., additional, Pearson, Christopher E., additional, Malkin, David, additional, Futreal, P Andrew, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, Campbell, Peter J., additional, and Tabori, Uri, additional

Published
2015
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70. List of Contributors

Author

BAXTER, WILLIAM J., primary, BUCK, OTTO, additional, CLARKE, DAVID R., additional, FINELLO, DUANE, additional, FRADIN, F.Y., additional, GRANT, RONALD W., additional, GRONSKY, RONALD, additional, HOUSLEY, ROBERT M., additional, KNAPP, G.S., additional, McMAHON, CHARLES J., additional, MARCHUT, LESLIE, additional, MARCUS, HARRIS L., additional, PARDEE, WILLIAM J., additional, PURUSHOTHAMAN, SAMPATH, additional, TAO, SIMON J., additional, THOMAS, GARETH, additional, TIEN, JOHN K., additional, and WALLACE, JOHN P., additional

Published
1979
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72. Impact of Vertebral Fractures and Glucocorticoid Exposure on Height Deficits in Children During Treatment of Leukemia.

Author

Ma, Jinhui, Siminoski, Kerry, Alos, Nathalie, Halton, Jacqueline, Ho, Josephine, Cummings, Elizabeth A, Shenouda, Nazih, Matzinger, Mary Ann, Lentle, Brian, Jaremko, Jacob L, Wilson, Beverly, Stephure, David, Stein, Robert, Sbrocchi, Anne Marie, Rodd, Celia, Lewis, Victor A, Laverdière, Caroline, Israels, Sara, Grant, Ronald M, Fernandez, Conrad V, Dix, David B, Couch, Robert, Cairney, Elizabeth, Barr, Ronald, Atkinson, Stephanie, Abish, Sharon, Moher, David, Rauch, Frank, and Ward, Leanne M

Abstract

To assess the effect of vertebral fractures (VF) and glucocorticoid (GC) exposure on height deficits in children during treatment of acute lymphoblastic leukemia (ALL).

Published
2019
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74. Canadian guideline on genetic screening for hereditary renal cell cancers

Author

Reaume, M. Neil, primary, Graham, Gail E., additional, Tomiak, Eva, additional, Kamel-Reid, Suzanne, additional, Jewett, Michael A.S., additional, Bjarnason, Georg A, additional, Blais, Normand, additional, Care, Melanie, additional, Drachenberg, Darryl, additional, Gedye, Craig, additional, Grant, Ronald, additional, Heng, Daniel Y.C., additional, Kapoor, Anil, additional, Kollmannsberger, Christian, additional, Lattouf, Jean-Baptiste, additional, Maher, Eamonn R., additional, Pause, Arnim, additional, Ruether, Dean, additional, Soulieres, Denis, additional, Tanguay, Simon, additional, Turcotte, Sandra, additional, Violette, Philippe D., additional, Wood, Lori, additional, Basiuk, Joan, additional, and Pautler, Stephen E., additional

Published
2013
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78. High Incidence of Vertebral Fractures in Children With Acute Lymphoblastic Leukemia 12 Months After the Initiation of Therapy

Author

Alos, Nathalie, primary, Grant, Ronald M., additional, Ramsay, Timothy, additional, Halton, Jacqueline, additional, Cummings, Elizabeth A., additional, Miettunen, Paivi M., additional, Abish, Sharon, additional, Atkinson, Stephanie, additional, Barr, Ronald, additional, Cabral, David A., additional, Cairney, Elizabeth, additional, Couch, Robert, additional, Dix, David B., additional, Fernandez, Conrad V., additional, Hay, John, additional, Israels, Sara, additional, Laverdière, Caroline, additional, Lentle, Brian, additional, Lewis, Victor, additional, Matzinger, MaryAnn, additional, Rodd, Celia, additional, Shenouda, Nazih, additional, Stein, Robert, additional, Stephure, David, additional, Taback, Shayne, additional, Wilson, Beverly, additional, Williams, Kathryn, additional, Rauch, Frank, additional, Siminoski, Kerry, additional, and Ward, Leanne M., additional

Published
2012
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83. Advanced Vertebral Fracture Among Newly Diagnosed Children With Acute Lymphoblastic Leukemia: Results of the Canadian Steroid‐Associated Osteoporosis in the Pediatric Population (STOPP) Research Program

Author

Halton, Jacqueline, primary, Gaboury, Isabelle, additional, Grant, Ronald, additional, Alos, Nathalie, additional, Cummings, Elizabeth A, additional, Matzinger, Maryann, additional, Shenouda, Nazih, additional, Lentle, Brian, additional, Abish, Sharon, additional, Atkinson, Stephanie, additional, Cairney, Elizabeth, additional, Dix, David, additional, Israels, Sara, additional, Stephure, David, additional, Wilson, Beverly, additional, Hay, John, additional, Moher, David, additional, Rauch, Frank, additional, Siminoski, Kerry, additional, and Ward, Leanne M, additional

Published
2009
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89. Topotecan Is Active Against Wilms’ Tumor: Results of a Multi-Institutional Phase II Study

Author

Metzger, Monika L., primary, Stewart, Clinton F., additional, Freeman, Burgess B., additional, Billups, Catherine A., additional, Hoffer, Fredric A., additional, Wu, Jianrong, additional, Coppes, Max J., additional, Grant, Ronald, additional, Chintagumpala, Murali, additional, Mullen, Elizabeth A., additional, Alvarado, Carlos, additional, Daw, Najat C., additional, and Dome, Jeffrey S., additional

Published
2007
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91. Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Author

Shlien, Adam, Meier, Bettina, Hong, Ye, Gartner, Anton, Remke, Marc, Thakkar, Neha P, Pearson, Christopher E, Hodel, Karl P, Henninger, Erin E, Göksenin, A Yasemin, Pursell, Zachary F, Bakry, Doua, Grant, Ronald, Nathan, Paul C, Alexander, Sarah, Charames, George S, Druker, Harriet, Lerner-Ellis, Jordan, Dvir, Rina, and Elhasid, Ronit

Subjects
SOMATIC mutation, DNA replication, POLYMERASES, GENOMES, BRAIN tumors, CANCER
Abstract

DNA replication−associated mutations are repaired by two components: polymerase proofreading and mismatch repair. The mutation consequences of disruption to both repair components in humans are not well studied. We sequenced cancer genomes from children with inherited biallelic mismatch repair deficiency (bMMRD). High-grade bMMRD brain tumors exhibited massive numbers of substitution mutations (>250/Mb), which was greater than all childhood and most cancers (>7,000 analyzed). All ultra-hypermutated bMMRD cancers acquired early somatic driver mutations in DNA polymerase ɛ or δ. The ensuing mutation signatures and numbers are unique and diagnostic of childhood germ-line bMMRD (P < 10−13). Sequential tumor biopsy analysis revealed that bMMRD/polymerase-mutant cancers rapidly amass an excess of simultaneous mutations (∼600 mutations/cell division), reaching but not exceeding ∼20,000 exonic mutations in <6 months. This implies a threshold compatible with cancer-cell survival. We suggest a new mechanism of cancer progression in which mutations develop in a rapid burst after ablation of replication repair. [ABSTRACT FROM AUTHOR]

Published
2015
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