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10,480 results on '"Guo, Rong"'

59. Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial

Author

Liu, Xu, Zhang, Yuan, Yang, Kun-Yu, Zhang, Ning, Jin, Feng, Zou, Guo-Rong, Zhu, Xiao-Dong, Xie, Fang-Yun, Liang, Xiao-Yu, Li, Wen-Fei, He, Zhen-Yu, Chen, Nian-Yong, Hu, Wei-Han, Wu, Hai-Jun, Shi, Mei, Zhou, Guan-Qun, Mao, Yan-Ping, Guo, Rui, Sun, Rui, Huang, Jing, Liang, Shao-Qiang, Wu, Wei-Li, Su, Zhen, Li, Ling, Ai, Ping, He, Yu-Xiang, Zang, Jian, Chen, Lei, Lin, Li, Huang, Shao Hui, Xu, Cheng, Lv, Jia-Wei, Li, Ying-Qing, Hong, Shu-Bin, Jie, Yu-Sheng, Li, Hao, Huang, Sai-Wei, Liang, Ye-Lin, Wang, Ya-Qin, Peng, Ying-Lin, Zhu, Jin-Han, Zang, Sheng-Bing, Liu, Song-Ran, Lin, Qing-Guang, Li, Hao-Jiang, Tian, Li, Liu, Li-Zhi, Zhao, Hong-Yun, Lin, Ai-Hua, Li, Ji-Bin, Liu, Na, Tang, Ling-Long, Chen, Yu-Pei, Sun, Ying, and Ma, Jun

Published
2024
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71. Near-horizon microstructure and superradiant instability of black holes

Author

Guo, Rong-Zhen, Yuan, Chen, and Huang, Qing-Guo

Subjects
General Relativity and Quantum Cosmology, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

Ultralight bosons, as important candidates of dark matter, can condense around spinning black holes (BHs) to form long-lived ``boson clouds'' due to superradiance instability. The boson-BH system can be observed through gravitational wave detection and may become a new window to find traces of ultralight bosons. In this letter we explore the effects on the superradiant instability of BHs from the near-horizon microstructure. By introducing the reflection parameter near a BH horizon, we derived analytical results on the corrections to both energy levels of bosonic cloud and its characteristic frequencies of superradiance instability. Our results imply that the evolution of a boson-BH system and gravitational waves it emits would be influenced by the near-horizon physics of a BH., Comment: 5 pages

Published
2021
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76. Displaying Cost and Completion Time for Reference Laboratory Test Orders-A Randomized Controlled Trial.

Author

Ikoma, Shohei, Pierce, Logan, Bell, Douglas S, Cheng, Eric M, Drake, Thomas, Guo, Rong, and Ziman, Alyssa

Subjects
Humans, Inpatients, Ambulatory Care Facilities, Practice Patterns, Physicians', Clinical Research, Clinical Trials and Supportive Activities, Health Services, Good Health and Well Being, decision support, clinical, review, quality improvement, Information Systems, Clinical Sciences
Abstract

ObjectivesReduction in unnecessary services is one strategy for increasing the value of health care. Reference laboratory, or send-out, tests are associated with considerable costs. We investigated whether displaying cost and turnaround time (TAT), or time-to-result, for reference laboratory tests at the time of order entry in the electronic health record (EHR) system would impact provider ordering practices.MethodsReference laboratory test cost and TAT data were randomized prior to the study and only displayed for the intervention group. A 24-month dataset composed of 12 months each for baseline and study periods was extracted from the clinical data mart. A difference-in-differences (DID) analysis was conducted using a linear mixed-effects model to estimate the association between the intervention and changes in test-ordering patterns.ResultsIn the inpatient setting, the DIDs of aggregate test-order costs and volume were not different among the control and intervention groups (p = 0.31 and p = 0.26, respectively). In the ambulatory setting, the DIDs of aggregate test-order costs and volume were not different among the control and intervention groups (p = 0.82 and p = 0.51, respectively). For both inpatient and ambulatory settings, no significant difference was observed in the DID of aggregate test-order costs and volumes calculated in respect to stratified relative cost and TAT groups (p > 0.05).ConclusionLack of alternative tests, test orders placed at a late step in patient management, and orders facilitated by trainees or mid-level providers may have limited the efficacy of the intervention. Our randomized study demonstrated no significant association between the display of cost or TAT display and ordering frequency.

Published
2022

77. Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue.

Author

Cohn, Whitaker, Zhu, Chunni, Campagna, Jesus, Bilousova, Tina, Spilman, Patricia, Teter, Bruce, Li, Feng, Guo, Rong, Elashoff, David, Cole, Greg M, Avidan, Alon, Faull, Kym Francis, Whitelegge, Julian, Wong, David TW, and John, Varghese

Subjects
Saliva, MicroRNAs, Exosomes, Biomarkers, biomarkers, cognitive impairment, exosomes, fatigue, microRNA, multiomics, proteomics, saliva, Biotechnology, Mental Health, Behavioral and Social Science, Dental/Oral and Craniofacial Disease, Genetics, Clinical Research, Cancer, Other Chemical Sciences, Other Biological Sciences, Chemical Physics
Abstract

Fatigue and other deleterious mood alterations resulting from prolonged efforts such as a long work shift can lead to a decrease in vigilance and cognitive performance, increasing the likelihood of errors during the execution of attention-demanding activities such as piloting an aircraft or performing medical procedures. Thus, a method to rapidly and objectively assess the risk for such cognitive fatigue would be of value. The objective of the study was the identification in saliva-borne exosomes of molecular signals associated with changes in mood and fatigue that may increase the risk of reduced cognitive performance. Using integrated multiomics analysis of exosomes from the saliva of medical residents before and after a 12 h work shift, we observed changes in the abundances of several proteins and miRNAs that were associated with various mood states, and specifically fatigue, as determined by a Profile of Mood States questionnaire. The findings herein point to a promising protein biomarker, phosphoglycerate kinase 1 (PGK1), that was associated with fatigue and displayed changes in abundance in saliva, and we suggest a possible biological mechanism whereby the expression of the PGK1 gene is regulated by miR3185 in response to fatigue. Overall, these data suggest that multiomics analysis of salivary exosomes has merit for identifying novel biomarkers associated with changes in mood states and fatigue. The promising biomarker protein presents an opportunity for the development of a rapid saliva-based test for the assessment of these changes.

Published
2022

78. US emergency care patterns among nurse practitioners and physician assistants compared with physicians: a cross-sectional analysis

Author

Mafi, John N, Chen, Alexander, Guo, Rong, Choi, Kristen, Smulowitz, Peter, Tseng, Chi-Hong, Ladapo, Joseph A, and Landon, Bruce E

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Health Services, Clinical Research, Cross-Sectional Studies, Emergency Service, Hospital, Humans, Nurse Practitioners, Physician Assistants, Physicians, United States, Health policy, ACCIDENT & EMERGENCY MEDICINE, Quality in health care, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

ObjectivesNurse practitioners and physician assistants (NPs/PAs) increasingly practice in emergency departments (EDs), yet limited research has compared their practice patterns with those of physicians.Design, setting and participantsUsing nationally representative data from the National Hospital Ambulatory Medical Care Survey (NHAMCS), we analysed ED visits among NPs/PAs and physicians between 1 January 2009 and 31 December 2017. To compare NP/PA and physician utilisation, we estimated propensity score-weighted multivariable regressions adjusted for clinical/sociodemographic variables, including triage acuity score (1=sickest/5=healthiest). Because NPs/PAs may preferentially consult physicians for more complex patients, we performed sensitivity analyses restricting to EDs with >95% of visits including the NP/PA-physician combination.ExposuresNPs/PAs.Main outcome measuresUse of hospitalisations, diagnostic tests, medications, procedures and six low-value services, for example, CT/MRI for uncomplicated headache, based on Choosing Wisely and other practice guidelines.ResultsBefore propensity weighting, we studied visits to 12 410 NPs/PAs-alone, 21 560 to the NP/PA-physician combination and 143 687 to physicians-alone who saw patients with increasing age (41, 45 and 47 years, p95% of NP/PA visits including the NP/PA-physician combination.Conclusions and relevanceWhile U.S. NPs/PAs-alone used less care and low-value advanced diagnostic imaging, the NP/PA-physician combination used more care and low-value advanced diagnostic imaging than physicians alone. Findings were reproduced among EDs where nearly all NP/PA visits were collaborative with physicians, suggesting that NPs/PAs seeing more complex patients used more services than physicians alone, but the converse might be true for more straightforward patients.

Published
2022

83. Tests for the existence of horizon through gravitational waves from a small binary in the vicinity of a massive object

Author

Fang, Yun, Guo, Rong-Zhen, and Huang, Qing-Guo

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

In this letter we calculate the gravitational waves (GWs) emitted from a small binary (SB) by solving the Teukolsky equation in the background of a massive exotic compact object (ECO) which is phenomenologically described by a Schwarzschild geometry with a reflective boundary condition at its "would-be" horizon. The "continuous echo" waves propagating to infinity due to reflectivity of ECO at its "would-be" horizon provide an exquisite probe to the nature of the ECO's horizon., Comment: 6 pages, 3 figures; Detectability of the continuous echo added

Published
2021
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