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67 results on '"Höllriegel, Robert"'

52. Chronic heart failure and aging – effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study.

Author

Sandri, Marcus, Viehmann, Manuel, Adams, Volker, Rabald, Kristin, Mangner, Norman, Höllriegel, Robert, Lurz, Philipp, Erbs, Sandra, Linke, Axel, Kirsch, Katharina, Möbius-Winkler, Sven, Thiery, Joachim, Teupser, Daniel, Hambrecht, Rainer, Schuler, Gerhard, and Gielen, Stephan

Published
2016
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54. TCT-108 Performance and Safety of the TRUE Dilatation™ Balloon Valvuloplasty Catheter for Aortic Balloon Valvuloplasty in Patients Undergoing TAVI

Author

Woitek, Felix, primary, Haussig, Stephan, additional, Mangner, Norman, additional, Höllriegel, Robert, additional, Boudriot, Enno, additional, Zimmer, Marion, additional, Rott, Beate, additional, Holzhey, David, additional, Mohr, Friedrich, additional, Schuler, Gerhard, additional, and Linke, Axel, additional

Published
2012
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56. Exercise Training in Patients With Advanced Chronic Heart Failure (NYHA IIIb) Promotes Restoration of Peripheral Vasomotor Function, Induction of Endogenous Regeneration, and Improvement of Left Ventricular Function

Author

Erbs, Sandra, primary, Höllriegel, Robert, additional, Linke, Axel, additional, Beck, Ephraim B., additional, Adams, Volker, additional, Gielen, Stephan, additional, Möbius-Winkler, Sven, additional, Sandri, Marcus, additional, Kränkel, Nicolle, additional, Hambrecht, Rainer, additional, and Schuler, Gerhard, additional

Published
2010
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57. Maximal exercise, limb ischemia, and endothelial progenitor cells

Author

Sandri, Marcus, primary, Beck, Ephraim Bernhard, additional, Adams, Volker, additional, Gielen, Stephan, additional, Lenk, Karsten, additional, Höllriegel, Robert, additional, Mangner, Norman, additional, Linke, Axel, additional, Erbs, Sandra, additional, Möbius-Winkler, Sven, additional, Scheinert, Dierk, additional, Hambrecht, Rainer, additional, and Schuler, Gerhard, additional

Published
2010
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59. Abstract 6262: Obesity in Childhood is Associated With an Impaired Regenerative Capacity of Circulating Progenitor Cells and Vascular Dysfunction

Author

Erbs, Sandra, primary, Höllriegel, Robert, additional, Linke, Axel, additional, Burman, Agnieszka, additional, Friebe, Daniela, additional, Sandri, Marcus, additional, Adams, Volker, additional, Töpfer, Madlen, additional, Walther, Claudia, additional, Schuler, Gerhard, additional, and Körner, Antje, additional

Published
2008
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62. Abstract 1884: Rosuvastatin Activates Circulating Stem and Progenitor Cells, Promotes Endogenous Tissue Regeneration, and Improves Central Hemodynamics in Patients With Chronic Heart Failure

Author

Erbs, Sandra, primary, Beck, Ephraim B, additional, Linke, Axel, additional, Adams, Volker, additional, Höllriegel, Robert, additional, Gielen, Stephan, additional, Möbius-Winkler, Sven, additional, Hambrecht, Rainer, additional, and Schuler, Gerhard, additional

Published
2007
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63. Maximal exercise, limb ischemia, and endothelial progenitor cells

Author

Sandri, Marcus, Beck, Ephraim Bernhard, Adams, Volker, Gielen, Stephan, Lenk, Karsten, Höllriegel, Robert, Mangner, Norman, Linke, Axel, Erbs, Sandra, Möbius-Winkler, Sven, Scheinert, Dierk, Hambrecht, Rainer, and Schuler, Gerhard

Abstract

Objectives:The concept of neovascularization in response to tissue ischemia was recently extended by the finding of postnatal vasculogenesis through circulating endothelial progenitor cells (EPCs). The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers.

Published
2011
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64. Endothelial progenitor cells: Implications for cardiovascular disease

Author

MöbiusWinkler, Sven, Höllriegel, Robert, Schuler, Gerhard, and Adams, Volker

Abstract

Endothelial progenitor cells EPCs reside in the bone marrow and are mobilized into the circulation by specific stimuli such as certain drugs, ischemia, and exercise training. Once in the circulation EPCs are thought to participate in the maintenance of the endothelial cell layer. Recently it was clearly demonstrated that the amount and function of EPCs is significantly impaired in different cardiovascular diseases. Furthermore, the level of circulating EPCs predicts the occurrence of cardiovascular events and death from cardiovascular causes and may help to identify patients at increased cardiovascular risk. After demonstrating the beneficial effect of applied EPCs in several animal experiments, these cells were also used to treat humans with different cardiovascular diseases. This review will focus on the characterization and liberation of EPCs from the bone marrow, as well as on the most important clinical cardiovascular diseases for which EPCs were used therapeutically. © 2008 International Society for Advancement of Cytometry

Published
2009
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66. Maximal exercise, limb ischemia, and endothelial progenitor cells.

Author

Sandri M, Beck EB, Adams V, Gielen S, Lenk K, Höllriegel R, Mangner N, Linke A, Erbs S, Möbius-Winkler S, Scheinert D, Hambrecht R, and Schuler G

Subjects
Adult, Biomarkers blood, Case-Control Studies, Cell Movement, Cells, Cultured, Endothelial Cells metabolism, Enzyme-Linked Immunosorbent Assay, Exercise Test, Female, Fibroblast Growth Factor 2 blood, Flow Cytometry, Germany, Granulocyte-Macrophage Colony-Stimulating Factor blood, Humans, Ischemia blood, Ischemia pathology, Ischemia physiopathology, Male, Middle Aged, Neovascularization, Physiologic, Peripheral Arterial Disease blood, Peripheral Arterial Disease pathology, Peripheral Arterial Disease physiopathology, Prospective Studies, Stem Cells metabolism, Time Factors, Tourniquets, Tumor Necrosis Factor-alpha blood, Vascular Endothelial Growth Factor A blood, Endothelial Cells pathology, Exercise Tolerance, Ischemia complications, Lower Extremity blood supply, Peripheral Arterial Disease complications, Stem Cells pathology
Abstract

Objectives: The concept of neovascularization in response to tissue ischemia was recently extended by the finding of postnatal vasculogenesis through circulating endothelial progenitor cells (EPCs). The aim of this study was to assess the role of acute ischemia for EPC mobilization in patients with peripheral arterial occlusive disease (PAOD) and in healthy volunteers., Methods: The number of circulating EPCs was analyzed by flow cytometry in PAOD patients (n = 23) with exercise-induced limb ischemia for up to 72 h after a maximal treadmill test and in healthy volunteers (n = 17) who underwent a 15-min suprasystolic occlusion of one lower extremity to induce limb ischemia. Plasma concentrations of vascular endothelial growth factor, basic fibroblast growth factor, tumor necrosis factor-α, and granulocyte macrophage-colony stimulating factor were determined by ELISA., Results: EPCs (CD 34 pos/KDRpos) increased significantly in both PAOD patients from 82 ± 20 to 256 ± 52 (P < 0.05) and healthy volunteers from 144 ± 39 to 590 ± 61 cells per 1 million events (P < 0.05) in response to induced ischemia, with a maximum after 24 h and returned to baseline within 72 h. The relative increase in EPC numbers was significantly lower in patients with PAOD as compared with healthy volunteers (P < 0.05). Plasma levels of vascular endothelial growth factor increased from 27.4 ± 3.1 to 126.4 ± 12 pg/ml in patients with PAOD (P < 0.05) and from 30.7 ± 6.1 to 134.1 ± 12.4 pg/ml in healthy volunteers (P < 0.05)., Conclusion: Both patients with symptomatic PAOD and healthy volunteers respond to a single episode of limb ischemia with a time-dependent increase in circulating EPCs. The increase of EPC numbers in response to ischemia is reduced when vascular disease is present, underlining the reduced vasculogenic potential of patients with PAOD.

Published
2011
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67. Endothelial progenitor cells: implications for cardiovascular disease.

Author

Möbius-Winkler S, Höllriegel R, Schuler G, and Adams V

Subjects
Animals, Bone Marrow Cells cytology, Bone Marrow Cells physiology, Cardiovascular Diseases metabolism, Chemokine CXCL12 metabolism, Endothelial Cells cytology, Erythropoietin metabolism, Exercise physiology, Humans, Insulin-Like Growth Factor I metabolism, Regeneration physiology, Stem Cells cytology, Vascular Endothelial Growth Factor A metabolism, Cardiovascular Diseases therapy, Endothelial Cells physiology, Endothelial Cells transplantation, Stem Cell Transplantation, Stem Cells physiology
Abstract

Endothelial progenitor cells (EPCs) reside in the bone marrow and are mobilized into the circulation by specific stimuli such as certain drugs, ischemia, and exercise training. Once in the circulation EPCs are thought to participate in the maintenance of the endothelial cell layer. Recently it was clearly demonstrated that the amount and function of EPCs is significantly impaired in different cardiovascular diseases. Furthermore, the level of circulating EPCs predicts the occurrence of cardiovascular events and death from cardiovascular causes and may help to identify patients at increased cardiovascular risk. After demonstrating the beneficial effect of applied EPCs in several animal experiments, these cells were also used to treat humans with different cardiovascular diseases. This review will focus on the characterization and liberation of EPCs from the bone marrow, as well as on the most important clinical cardiovascular diseases for which EPCs were used therapeutically.

Published
2009
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