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Francis and Callender1 were able to obtain and study histologically material from only ten of the 323 cases of tularemia reported prior to 1927. During the first nine months of 1927 we have reviewed twenty-five additional case reports but have not found any further reference to the pathologic histology. The tissue in three of the ten cases studied by Francis and Callender was obtained at necropsy; study of the other seven cases was limited to the surgical material. Bacterium tularense was demonstrated in three of the ten cases. The clinical observations together with the agglutination test were assumed specific enough to brand the remaining seven cases as tularemia. The time elapsing between the onset of illness and the time the material for histologic study was taken ranged from eighteen to ninety-nine days in the cases examined at necropsy and from twelve to 240 days in those examined at biopsy.

Scattered through the literature are a number of records of damage associated with the use of various ointments containing insoluble compounds of mercury. It is a common belief that such use may be associated not only with varying degrees of local irritation but also with general effects varying from slight functional disturbance to fatal damage. Indeed, merely because such materials contain the potentially dangerous mercury, little hesitation is manifested in accepting such views without further question.Today the problem has assumed a new and practical aspect for two reasons. The first is that the new food and drug laws have given the authorities the power to remove dangerous materials from public availability; the second, that new physiologic and pathologic conceptions of repair processes raise the interesting question whether small, individually innocuous doses of this type of material can really lead to poisoning.The use of mercury on the skin by

The occurrence of retroperitoneal neoplasms arising independently of the adult urogenital organs has, to date, eluded scientific explanation. Until about 1880, these tumors were diagnosed as sarcoma or pancreatic cyst and dismissed without further consideration or study. Howship, in 1871, had observed a composite tumor possessing certain characteristics similar to dermoid teratomas commonly found in the ovary. In 1889, Bassini described a cystic adenoma morphologically resembling a pseudomucinous cystadenoma of the ovary, and Frank, in 1894, observing a similar tumor, attributed its histogenesis to an accessory ovary. Since 1894, instances of unattached retroperitoneal tumors have been reported in the medical literature, averaging somewhat less than one case a year. Occasionally, authors of these case reports have added to the diversity of histologic features that may be associated with these neoplasms. These now include glomeruli, renal tubules, rete structures, bone, hair, sweat glands, fat, smooth muscle, uterine mucosa and chorion epithelium.

The descriptions of the tumors arising in the nose and in the accessory sinuses give rise to considerable confusion and do not appear to be adequately understood either from the clinical or from the pathologic viewpoints. The textbooks have little to say concerning these lesions and the nomenclature is especially confusing. This is particularly true concerning that type of vascular tumor variously described as angioma, angiosarcoma, and hemangio-endothelio fibroblastoma. The reasons for these innumerable diagnoses of the blood vessel neoplasms in the nasal mucous membrane apparently are: the rarity of the condition, the fact that the tissues obtained for histologic examination are very scanty in amount or are traumatized in removal, or the fact that the histologic picture may be altered by previous radium therapy and infection. PATHOLOGY Hemangio-endotheliomas of the nasal mucous membrane are designated by many names. Some of the tumors that have been described as angioma, angiosarcoma,

Since the review of the literature and the report of a case by one of us (Dr. Hansmann), which coupled certain gross as well as histologic features of the tumor concerned with residual structures of the neurenteric canal, reports of composite tumors immediately anterior to the sacrum have from time to time appeared in the medical literature. A review of these cases has convinced us that the idea of histogenesis is still vague in the reported cases. If the interpretation is correct that no inconsiderable number of these retrorectal tumors arise from remnants of the neurenteric canal, this information would be important in the study of the clinical cases preliminary to the therapeutic removal of the aberrant tissue. We have recently had another patient with a rather unusual retrorectal tumor. The nature of the tumor, the excellent result from surgical removal and the apparent need for a reiteration of the

The literature on intra-abdominal hernia is composed for the most part of individual case reports, studies of limited groups of cases and reviews of special types of hernia. Moynihan and Dobson described various peritoneal fossae and made a fairly complete review of the cases of intra-abdominal hernia reported up to 1906. Short reviewed the cases reported between 1906 and 1915. In 1925 Short also reviewed cases in which there were clinical symptoms. No complete survey of the subject has been offered since 1906. Such a survey appears to us timely.In this article we propose to review the entire subject of intra-abdominal hernia, report a unique case and make conclusions based on the experience with our own case and on the records of previously reported cases. We believe that such information, concretely assembled, will be of value to others. REPORT OF CASE The patient was a 58 year old man,

Since Filatow's1 first allusion in 1885 to an idiopathic lymph adenopathy there have been more than 110 articles published on glandular fever, and about half as many articles on similar or identical conditions variously named. In the eighteen nineties numerous small epidemics were reported in England, on the Continent, and in this country. In 1907 Turk2 reported blood observations in cases with lymphadenopathy, and since 1920 there has been a generalized feeling that mononucleosis is a constant feature of glandular fever.Even now, forty-one years after the first recorded observations on the disease, there is considerable confusion, and some able clinicians are inclined to disregard the whole group of cases rather than draw definite conclusions as to the existence of a true disease entity among them. Until recently most important textbooks and systems of medicine contained at most only brief mention of the condition. The clinical features of glandular fever,

Mycotic aneurysms of the aorta occasionally develop during the course of intravascular infection. In most instances they are associated with a subacute bacterial endocarditis. They are usually small and rarely discovered until necropsy. This case is of interest because of the size and location of the aneurysm and the associated pathology. REPORT OF CASE HISTORY. —R. F., a boy, aged 17 years, was admitted to the University Hospital, Jan. 7, 1925. He complained of distress in the precordial region; pain in the left hip; weakness, and epistaxis. He stated that he had had measles and whooping cough in early childhood and rheumatic fever in 1919. After the latter illness the medical history was negative except for an occasional cold.The present illness began in October, 1924, with fever, night sweats, loss of weight and frequent nosebleeds. He had had a daily afternoon temperature which usually reached 102 F. In November

During the past three years we have carried out about 180 renal dietary tests and blood analyses. Most of the cases were diagnosed nephritis or arteriosclerosis, though a number of other diseases have been included in the tables. The routine employed was as follows: The blood for analysis was collected before breakfast. The patients were in bed during the dietary test. They received a uniform quantity of water and food. In most instances the Mosenthal1 modification of the Hedinger and Schlayer2 diet was administered. The urine was collected in two hour periods from 8 a. m. to 8 p. m., and in one period from 8 p. m. to 8 a. m.Recently Mosenthal3 and Schlayer and Beckmann4 compared the effect of a low protein or bland diet with that of the usual test diet. The former author found that both had approximately the same effect on the urine. Schlayer

The material for this study consisted of twenty-seven cases of pernicious anemia, and as pathologic controls nine miscellaneous conditions which included one case each of chlorosis, carcinoma ventriculi, purpura, familial hemolytic icterus, Banti's disease, lymphosarcoma, acute cholecystitis, hemochromatosis, and tabes dorsalis.The method was a modification of Wilbur and Addis'1 spectroscopic method. The modification was instrumental and has been described recently by J. D. Boyd,2 working in our laboratory under the direction of Dr. Louis Baumann. The instrument "was constructed from a Hellige colorimeter and a hand spectroscope and consisted essentially of a hollow glass wedge which can be moved vertically before a fixed spectroscope" (8 cm.). The sample is prepared in the usual manner. "The cell, which holds about 10 c.c., is filled with the solution, and the point is found when the spectrum just disappears with moderate light3 but reappears when the light is diminished by

The recent prevalence of syphilis as claimed by the propaganda arising from the United States Public Health Service was outright astounding to me. During twenty-four years of endeavor as a medical student and worker in laboratory medicine, in the course of which time thousands of postmortem examinations, examinations of surgical specimens and serum tests for syphilis were both accomplished personally and personally directed, I have witnessed syphilis in four sections of the country dwindle from a common experience with full blown active lesions to an occasional positive serologic test, a few scars of the aorta, a rare scarred liver presumably syphilitic, a slightly more frequent syphilis scarred central nervous system, and about twice a year an actual case of congenital syphilis.I had not insisted on a routine serologic test for syphilis because syphilis rarely was evident at postmortem and surgical specimen examinations, in the run of clinical cases, in