[Author Affiliation]Heidi M. Blanck. Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.Janet L. Collins. Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.Address correspondence to: Heidi M. Blanck, PhD, Branch Chief, Obesity Prevention and Control Branch, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, F77, Atlanta, GA 30341, E-mail: hcb3@cdc.govChildhood obesity is a serious national health problem with 17% of American youth living with obesity.1 In 2010, the Patient Protection and Affordable Care Act (ACA) appropriated $25 million for a 4-year community-based study to determine whether an integrated model of primary care and public health services can improve underserved children's risk factors for obesity. In response, the CDC established the Childhood Obesity Research Demonstration (CORD) to meet the requirements of the ACA and address the call by expert groups for comprehensive, multilevel, multisetting approaches to prevent and reduce childhood obesity.2 This commentary introduces the nine articles in this issue that describe the research collaboration funded by the CDC.Obesity-related health behaviors, such as nutrition and physical activity, are shaped by multiple sources of influence and environments, including the home, early care and education, school, healthcare, and other community settings. Therefore, a host of setting stakeholders who influence these settings, including government, education, the private setting, nonprofit organizations, and families, have a role to play in creating healthier communities. CORD will add to the limited research available on comprehensive, community-wide models for childhood obesity prevention. A recent comparative effectiveness review of the peer-reviewed childhood obesity prevention literature in developed countries found there is a need for more studies that include results from interventions occurring in multiple settings.3 The systematic review found a very limited number of articles with multiple settings and only one community-based, multiple-setting, early childhood obesity prevention study that measured weight and had at least 1 year of follow-up.4 In school-aged youth in the United States, Shape Up Somerville has been novel in its results of reducing BMI over 2 years through a community-based participatory research approach that met the community's interests and strengths and interventions that could be included into existing "platforms" (schools, afterschool, and community).5The collection of articles in this supplement to Childhood Obesity describes how CORD builds on each community's existing work, uses its stakeholders' perspectives of problems and feasible solutions, and leverages state and local infrastructure in three states: Imperial County, California; Fitchburg and New Bedford, Massachusetts; and Austin and Houston, Texas. Each of the three demonstration sites serves children ages 2-12 years and their families in communities with high childhood obesity rates.While we wait for final evaluation data from each of the demonstration sites, we are learning about novel ways that public health and primary care can work together to embed healthy eating and active living in the daily routines of children and families. CORD is increasing healthy eating and active living opportunities for young children and their families by supporting change at the individual, system, and community levels. Interventions in each setting include those reviewed and described by Foltz and colleagues on population-based research and practice-tested strategies for improving obesity-related behaviors. …