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51. Lymph node classification systems in cutaneous T-cell lymphoma: evidence for the utility of the Working Formulation of Non-Hodgkin's Lymphomas for Clinical Usage

Author

Vonderheid, Eric C., Diamond, Lawrence W., Vloten, Willem A. van, Scheffer, Erik, Meijer, Chris J.L.M., Cashell, Alan W., Hardman, Jane M., Lai, Sue-Min, Hermans, Jo, and Matthews, Mary J.

Subjects
Non-Hodgkin's lymphomas -- Diagnosis, Health
Abstract

Background. This study was undertaken to compare three classification schemes used to evaluate lymph nodes (LN) obtained from patients with cutaneous T-cell lymphoma (CTCL): a modified Rappaport classification, the National Cancer Institute-Veterans Administration (NCI-VA) classification based on the relative numbers of cerebriform cells in the paracortical areas, and the Dutch classification based on the presence of cerebriform cells with large nuclei in mycosis fungoides (MF) and diffuse infiltration by cerebriform cells in Sezary syndrome. Methods. A study set of 195 LN obtained from patients with CTCL (MF, Sezary syndrome, and nonepidermotropic T-cell lymphomas) and 14 LN from patients with benign dermatoses was reviewed independently by three groups of pathologists familiar with each classification system. Results. Each classification system provided useful prognostic information. However, contrary to prior reports, no significant difference in survival was apparent in patients with uneffaced LN when classified according to the NCI-VA (LNO-2 versus LN3) or Dutch (GrO-1 versus Gr2) ratings. In addition, all classification systems demonstrated a poor survival time associated with effaced LN. By combining results from the modified Rappaport and Dutch classifications, three prognostic groups could be identified based on cell morphology: a low-grade category with a small cell histologic subtype (median survival time, 40 months); a high-grade immunoblastic subtype (median survival time, 9 months) composed of cells with an oval nucleus containing a large, usually solitary central nucleolus; and an intermediate-grade category composed of all cases without the distinctive small cell and immunoblastic morphologies (median survival time, 26 months). Conclusions. The authors propose that clearly involved LN in CTCL can be categorized on the basis of cell morphology into prognostic groups analogous to what has been proposed for the Working Formulation for Non-Hodgkin's Lymphomas for Clinical Usage.

Published
1994

52. The value of aspiration cytologic examination of the breast: a statistical review of the medical literature

Author

Giard, Raimond W.M. and Hermans, Jo

Subjects
Breast cancer -- Diagnosis, Breast examination -- Medical examination, Biopsy, Needle, Health
Abstract

The decision to perform surgery in patients with a breast mass usually is made on the basis of combined diagnostic information, with fine-needle aspiration cytologic examination (FNAC) playing a central role. To determine and compare the quality of FNAC of the breast, a search was performed on the English literature for articles with quantitative information about their results. Twenty-nine such articles, containing 31,340 aspirations, were identified and summarized. Required data were extracted from these articles. These numbers were analyzed with the use of two-by-four contingency table to relate the FNAC result (definitely malignant, suspect, benign, or unsatisfactory cytologic material) with the final diagnosis (malignant or benign breast disease). Test characteristics such as sensitivity, specificity, and the likelihood ratios for the four different FNAC results were derived for each study and compared. There was a striking difference between studies with regard to the probability of a particular FNAC upshot (e.g., in patients with breast cancer, the chance of obtaining definitely malignant cytologic material ranged from 0.35 to 0.92), the sensitivity (range, 0.65 to 0.98), the specificity (range, 0.34 to 1.0), and likelihood ratios. In the opinion of the authors, it is virtually impossible to infer general test characteristics of FNAC of the breast from the medical literature because of differences in methods and different biases. At best, the maximum attainable performance of this test can be described. For the development of a policy for breast mass management, the local test characteristics of this highly operator-dependent test should be established. Cancer 1992; 69:2104-2110.

Published
1992

54. Chronic mesenteric vascular syndrome: results of reconstructive surgery

Author

Geelkerken, Robert H., Bockel, Hajo van, Roos, Wilfred K. de, Hermans, Jo, and Terpstra, Johan L.

Subjects
Mesentery -- Abnormalities, Health
Abstract

The abdominal organs are covered and supported by strong connective tissue called mesentery, which extends from the abdominal wall. The blood vessels that supply the abdominal organs with blood travel to their destination through this connective tissue. Many people have atherosclerotic plaques within these blood vessels. However, in contrast to the blood vessels of the heart or the brain, the occlusions of the mesenteric arteries rarely cause symptoms. Chronic mesenteric vascular syndrome results when these occlusions of the blood vessels significantly affect the flow of blood to the abdominal organs and cause pain, usually after eating. The condition causes noises or murmurs which can be heard on physical examination. In such cases, the flow of blood may be further interrupted by a blood clot blocking the already narrowed arteries. The blood flow to the bowel may be interrupted sufficiently to cause a bowel infarction, a destruction of bowel tissues. The rate of death due to bowel obstruction is very high, and many physicians believe the risk of bowel infarction is sufficient to justify surgery for chronic mesenteric vascular disease. The condition may be treated by surgical reconstruction of the damage and occluded blood vessels. However, it is difficult to determine how successful this surgical treatment is, since many of the published studies included a variety of different patients with widely disparate extent of disease, age, and general health. A series of 42 arteries were examined in 14 patients. Thirty-one of these arteries were severely obstructed or stenotic and 23 were surgically repaired. Thirteen of the patients remain alive at an average of 11.8 years after their surgery. Detailed examination using X-ray techniques was performed as a part of the follow-up for eight patients. These eight patients had received surgery on 13 arteries; 11 of these reconstructed arteries were still open to the flow of blood. The follow-up of these patients demonstrates that surgical reconstruction of the mesenteric arteries provides long-lasting benefits including improved blood flow and relief of pain. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

58. Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific immune response has only a systemic effect - a histopathological and immunohistochemical study

Author

Mulder-Stapel Adri, Kranenbarg Elma Klein, Marijnen Corrie AM, Nagtegaal Iris D, Hermans Jo, van de Velde Cornelis JH, and van Krieken J Han JM

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Invasion and metastasis is a complex process governed by the interaction of genetically altered tumor cells and the immunological and inflammatory host reponse. Specific T-cells directed against tumor cells and the nonspecific inflammatory reaction due to tissue damage, cooperate against invasive tumor cells in order to prevent recurrences. Data concerning involvement of individual cell types are readily available but little is known about the coordinate interactions between both forms of immune response. Patients and methods The presence of inflammatory infiltrate and eosinophils was determined in 1530 patients with rectal adenocarcinoma from a multicenter trial. We selected 160 patients to analyze this inflammatory infiltrate in more detail using immunohistochemistry. The association with the development of local and distant relapses was determined using univariate and multivariate log rank testing. Results Patients with an extensive inflammatory infiltrate around the tumor had lower recurrence rates (3.4% versus 6.9%, p = 0.03), showing the importance of host response against tumor cells. In particular, peritumoral mast cells prevent local and distant recurrence (44% versus 15%, p = 0.007 and 86% versus 21%, p < 0.0001, respectively), with improved survival as a consequence. The presence of intratumoral T-cells had independent prognostic value for the occurrence of distant metastases (32% versus 76%, p < 0.0001). Conclusions We showed that next to properties of tumor cells, the amount and type of inflammation is also relevant in the control of rectal cancer. Knowledge of the factors involved may lead to new approaches in the management of rectal cancer.

Published
2001
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59. L'énergie sous toutes ses formes II : ses différentes sources

Author

Hermans, Jo, Hermans, Jo, Hermans, Jo, and Hermans, Jo

Abstract

L’énergie baigne notre Monde : sans elle, pas un mouvement, pas une action, pas de vie. Elle est omniprésente dans notre quotidien – transport, eau chaude, électroménager – et dans le débat public. Quelles énergies pour demain ? Quel impact sur le climat ? Quels défis techniques, quels risques ? Jusqu’à nos spots de pub : « L’énergie est notre avenir, économisons-là » ! Nous connaissons en effet une parenthèse enchantée mais provisoire de l’histoire humaine : celle de l’énergie disponible et bon marché. Pour autant, ce qui se cache derrière le mot « énergie » n’est pas si clair. Pas facile de comprendre les enjeux des débats sur la transition énergétique, souvent trop techniques ou partisans. Cet ouvrage aborde avec pédagogie mais sans simplisme des grands sujets de l’énergie. En parcourant ce deuxième tome, vous verrez comment exploiter l’énergie solaire et celle du vent, mais aussi celle des vagues, des marées, des lacs et du centre de la Terre. Vous recevrez un éclairage technique sur les opportunités et les risques du nucléaire ainsi que sur les espoirs placés dans la fusion. Vous mettrez de l’hydrogène dans votre réservoir et réf échirez au stockage d’énergie de demain. En parcourant les différentes sources d’énergie, vous comprendrez la complexité des choix et la richesse des opportunités qui s’offrent à nous. Jo Hermans est professeur émérite de physique à l’Université de Leiden, aux Pays-Bas. En complément de son engagement dans l’enseignement et la recherche, il est l’auteur de plusieurs ouvrages de vulgarisation scientifique où il explique avec clarté, rigueur et humour les phénomènes physiques qui accompagnent notre quotidien. Pierre Manil est ingénieur-chercheur au Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA). Il dirige le bureau d’études mécaniques de l’Institut de Recherche sur les lois Fondamentales de l’Univers (Irfu).

Published
2014

60. L'énergie sous toutes ses formes I : Comment se transforme t-elle?

Author

Hermans, Jo, Hermans, Jo, Hermans, Jo, and Hermans, Jo

Abstract

L’énergie baigne notre Monde : sans elle, pas un mouvement, pas une action, pas de vie. Elle est omniprésente dans notre quotidien – transport, eau chaude, électroménager – et dans le débat public. Quelles énergies pour demain ? Quel impact sur le climat ? Quels défis techniques, quels risques ? Jusqu’à nos spots de pub : « L’énergie est notre avenir, économisons-là » ! Nous connaissons en effet une parenthèse enchantée mais provisoire de l’histoire humaine : celle de l’énergie disponible et bon marché. Pour autant, ce qui se cache derrière le mot « énergie » n’est pas si clair. Pas facile de comprendre les enjeux des débats sur la transition énergétique, souvent trop techniques ou partisans. Cet ouvrage aborde avec pédagogie mais sans simplisme des grands sujets de l’énergie. Avec ce premier tome, vous en saurez plus sur la nature de l’énergie et sa place dans nos vies quotidiennes, en France et ailleurs. Vous verrez comment on la consomme et son lien avec le réchauffement climatique. Vous vous poserez la question du mode de transport le moins énergivore et mettrez en balance les bons et les mauvais côté d’un bain chaud. Vous reviendrez au temps des moulins à vent, touillerez la soupe, monterez les marches et embarquerez sur un dirigeable. En découvrant comment elle se transforme, vous verrez l’énergie sous toutes ses formes. Jo Hermans est professeur émérite de physique à l’Université de Leiden, aux Pays-Bas. En complément de son engagement dans l’enseignement et la recherche, il est l’auteur de plusieurs ouvrages de vulgarisation scientifique où il explique avec clarté, rigueur et humour les phénomènes physiques qui accompagnent notre quotidien. Pierre Manil est ingénieur-chercheur au Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA). Il dirige le bureau d’études mécaniques de l’Institut de Recherche sur les lois Fondamentales de l’Univers (Irfu).

Published
2014

61. No effect of intramuscular gold therapy on serological parameters of Helicobacter pylori infection in patients with rheumatoid arthritis: a 12 month prospective study

Author

Wolde, Saskia ten, Janssen, Matthijs, Duijn, Wim van, Lamers, Cornelis B.H.W., Hermans, Jo, and Dijkmans, Ben A.C.

Subjects
Gold -- Health aspects, Rheumatoid arthritis -- Care and treatment, Helicobacter infections -- Physiological aspects, Health
Abstract

Injection of gold to treat rheumatoid arthritis (RA) may not be effective against Helicobacter pylori infections. A study of 50 RA patients found that 12 months of gold therapy by intramuscular injection did not eradicate Helicobacter pylori from the patients' blood. H. pylori is often found in RA patients, and may cause peptic ulcer disease. The gold therapy did not significantly lower the prevalence of H. pylori nor did it decrease Immunoglobulin A or Immunoglobulin G antibodies. Conventional antibiotic triple therapy consisting of colloidal bismuth subcitrate, metronidazole and amoxicillin is much more effective in eradicating H. pylori in RA patients.

Published
1994

66. Energy survival guide: insight and outlook

Author

Hermans, Jo

Subjects
Science in General
Abstract

Do those huge windmills really make sense? Can solar energy provide the entire world’s electricity? Should we stop building nuclear power plants after Fukushima? Why don’t we use wave power? How much do I save by installing double glazing? What about using solar panels? Is taking the train more efficient than travelling by plane or car? What’s wrong with electric cars? These are just examples of questions people ask. This book provides the answers. It comes to the rescue of anyone who wants to know the facts. It makes the world of energy accessible to all. This book provides the answers, presenting clear insights into the current state of affairs and exploring future prospects. Every statement is backed by facts and figures, leading to conclusions that are hard to contest.

Published
2011

68. The Dutch Normal-Pressure Hydrocephalus Study. How to select patients for shunting? An analysis of four diagnostic criteria

Author

Boon, Agnita J.W., Tans, Joseph Th J., Delwel, Ernst J., Egeler-Peerdeman, Saskia M., Hanlo, Patrick W., Wurzer, Hans A.L., Hermans, Jo, Neurosurgery, AII - Cancer immunology, and CCA - Cancer biology and immunology

Abstract

BACKGROUND. Comparison of the predictive value of four 'diagnostic tests' for the outcome of shunting in patients with normal-pressure hydrocephalus (NPH). METHODS. Ninety-five NPH patients who received shunts were followed for 1 year. Gait disturbance and dementia were quantified by an NPH scale and handicap by a modified Rankin scale. Primary outcome measures were differences between the preoperative and last scores on both the NPH scale and the modified Rankin scale. Clinical and computed tomographic (CT) findings typical of NPH, absence of cerebrovascular disease, and a resistance to outflow of cerebrospinal fluid (CSF) ≥ 18 mmHg/ml/minute were designated as a positive test outcome; clinical and CT findings compatible with NPH, presence of cerebrovascular disease, and an outflow resistance < 18 mmHg/ml/minute as a negative test outcome. RESULTS. For each of the four tests the percentage of patients classified as improved was significantly greater for those with positive than with negative test results. Measurement of CSF outflow resistance was the only significant prognostic factor for the improvement ratio in NPH scale and CT in the modified Rankin scale according to multivariate logistic regression analysis. The accurate predictive value of the combination of typical clinical and CT findings was 0.65, that of the positive test results of outflow resistance, clinical and CT findings was 0.74. CONCLUSION. The best strategy is to shunt NPH patients if their outflow resistance is ≥ 18 mmHg/ml/minute or, when the outflow resistance is lower, if their clinical as well as their CT findings are typical of NPH. Copyright (C) 2000 Elsevier Science Inc.

Published
2000

77. European therapeutic trials in ANCA-associated systemic vasculitis: Disease scoring, consensus regimens and proposed clinical trials EUROPEAN COMMUNITY STUDY GROUP ON CLINICAL TRIALS IN SYSTEMIC VASCULITIS ECSYSVASTRIAL (BMHl-Cr93-1078)

Author

Rasmussen, Niels, Jayne, David R.W.David, Lockwood, Christopher Martin, Abramowicz, Daniel, Andrassy, Konrad, Bacon, Paul P.A., Savage, Caroline, Cohen Tervaert, Jan J.W., Kallenberg, Cees Gm, Dadonlené, J., Feighery, Conleth, Van Es, Leendert L.A., Hermans, Jo, van der Woude, Fokko J, Ferrario, Franco, Sinico, Renato A, Gaskin, Gill, Pusey, Charles Dickson, Gregorini, Gina, De Groot, Kirsten, Gross, Wolfgang Ludwig, Gronhagen-Riska, Carola, Guillevin, Loïc, Hagen, Ernst Christiaan, Heigl, Z., Landais, Paul, Lesavre, Philippe, Luqmani, R., Mirapeix, Eduard, Pettersson, Erna, Specks, Ulrich, Tzioufas, Athanasios, Westman, Kerstin W A, Wiik, Allan, Rasmussen, Niels, Jayne, David R.W.David, Lockwood, Christopher Martin, Abramowicz, Daniel, Andrassy, Konrad, Bacon, Paul P.A., Savage, Caroline, Cohen Tervaert, Jan J.W., Kallenberg, Cees Gm, Dadonlené, J., Feighery, Conleth, Van Es, Leendert L.A., Hermans, Jo, van der Woude, Fokko J, Ferrario, Franco, Sinico, Renato A, Gaskin, Gill, Pusey, Charles Dickson, Gregorini, Gina, De Groot, Kirsten, Gross, Wolfgang Ludwig, Gronhagen-Riska, Carola, Guillevin, Loïc, Hagen, Ernst Christiaan, Heigl, Z., Landais, Paul, Lesavre, Philippe, Luqmani, R., Mirapeix, Eduard, Pettersson, Erna, Specks, Ulrich, Tzioufas, Athanasios, Westman, Kerstin W A, and Wiik, Allan

Abstract

SCOPUS: ar.j, FLWIN, info:eu-repo/semantics/published

Published
1995

78. Haematopoietic stem cell transplantation for patients with myelo‐dysplastic syndromes and secondary acute myeloid leukaemias: a report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

Author

De Witte, Theo, primary, Hermans, Jo, additional, Vossen, Jaak, additional, Bacigalupo, Andrea, additional, Meloni, Giovanna, additional, Jacobsen, Niels, additional, Ruutu, Tapani, additional, Ljungman, Per, additional, Gratwohl, Alois, additional, Runde, Volker, additional, Niederwieser, Dietger, additional, Van Biezen, Anja, additional, Devergie, Agnes, additional, Cornelissen, Jan, additional, Jouet, Jean‐Pierre, additional, Arnold, Renate, additional, and Apperley, Jane, additional

Published
2000
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80. Complications of Hysteroscopy

Author

JANSEN, FRANK WILLEM, primary, VREDEVOOGD, CORLA B., additional, VAN ULZEN, KARIN, additional, HERMANS, JO, additional, TRIMBOS, J. BAPTIST, additional, and TRIMBOS-KEMPER, TRUDY C. M., additional

Published
2000
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86. Detection and typing of human papillomavirus in cervical carcinomas in Russian women

Author

van Muyden, Ruud C. P. A., primary, ter Harmsel, Bram W. A., additional, Smedts, Frank M. M., additional, Hermans, Jo, additional, Kuijpers, Johan C., additional, Raikhlin, Nathan T., additional, Petrov, Semyon, additional, Lebedev, Anatoly, additional, Ramaekers, Frans C. S., additional, Trimbos, J. Baptist, additional, Kleter, Bernhard, additional, and Quint, Wim G. V., additional

Published
1999
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90. Treatment, patterns of failure, and survival of patients with Stage I nodal and extranodal non-Hodgkin's lymphomas, according to data in the population-based registry of the comprehensive cancer centre west

Author

Krol, Augustinus D., primary, Hermans, Jo, additional, Dawson, Lilian, additional, Snijder, Simone, additional, Wijermans, Pierre W., additional, Kluin-Nelemans, Hanneke C., additional, Kluin, Philip M., additional, Krieken, J. Han van, additional, and Noordijk, Evert M., additional

Published
1998
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96. Dutch Normal-Pressure Hydrocephalus Study: prediction of outcome after shunting by resistance to outflow of cerebrospinal fluid

Author

Boon, Agnita J. W., primary, Tans, Joseph T. J., additional, Delwel, Ernst J., additional, Egeler-Peerdeman, Saskia M., additional, Hanlo, Patrick W., additional, Wurzer, Hans A. L., additional, Avezaat, Cees J. J., additional, de Jong, Dirk A., additional, Gooskens, Rob H. J. M., additional, and Hermans, Jo, additional

Published
1997
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98. Complications of Laparoscopy

Author

Jansen, Frank Willem, primary, Kapiteyn, Kitty, additional, Trimbos-Kemper, Trudy, additional, Hermans, Jo, additional, and Trimbos, J. Baptist, additional

Published
1997
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