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The analysis of 20 years of spectrophotometric data of the double shell planetary nebula PM\,1-188 is presented, aiming to determine the time evolution of the emission lines and the physical conditions of the nebula, as a consequence of the systematic fading of its [WC\,10] central star whose brightness has declined by about 10 mag in the past 40 years. Our main results include that the [\ion{O}{iii}], [\ion{O}{ii}], [\ion{N}{ii}] line intensities are increasing with time in the inner nebula as a consequence of an increase in electron temperature from 11,000 K in 2005 to more than 14,000 K in 2018, due to shocks. The intensity of the same lines are decreasing in the outer nebula, due to a decrease in temperature, from 13,000 K to 7,000 K, in the same period. The chemical composition of the inner and outer shells was derived and they are similar. Both nebulae present subsolar O, S and Ar abundances, while they are He, N and Ne rich. For the outer nebula the values are 12+log He/H= 11.13$\pm$0.05, 12+log O/H = 8.04$\pm$0.04, 12+log N/H= 7.87$\pm$0.06, 12+log S/H = 7.18$\pm$0.10 and 12+log Ar = 5.33$\pm$0.16. The O, S and Ar abundances are several times lower than the average values found in disc non-Type I PNe, and are reminiscent of some halo PNe. From high resolution spectra, an outflow in the N-S direction was found in the inner zone. Position-velocity diagrams show that the outflow expands at velocities in the $-$150 to 100 km s$^{-1}$ range, and both shells have expansion velocities of about 40 km s$^{-1}$., Comment: 15 pages, 6 figures, acepted in MNRAS

Orion BN/KL is an example of a poorly understood phenomena in star forming regions involving the close encounter of young stellar objects. The explosive structure, the great variety of molecules observed, the energy involved in the event and the mass of the region suggest a contribution in the {chemical diversity} of the local interstellar medium. Nevertheless, the frequency and duration of other events like this have not been determined. In this paper, we explore a recent analytic model that takes into account the interaction of a clump with its molecular environment. We show that the widespread kinematic ages of the Orion fingers -- 500 to 4000 years -- is a consequence of the interaction of the explosion debris with the surrounding medium. This model explains satisfactorily the age discrepancy of the Orion fingers, and infers the initial conditions together with the lifetime of the explosion. Moreover, our model can explain why some CO streamers do not have a H$_2$ finger associated., Comment: 10 figures, 7 pages

Biexcitons have been considered as one of the fundamental building blocks for quantum technology because of its overwhelming advantages in generating entangled photon pairs. Although many-body complexes have been demonstrated recently in mono-layer transition metal dichalcogenides (TMDs), the low emission efficiency and scale up capability hinder their applications. Colloidal nanomaterials, with high quantum efficiency and ease of synthesis/processing, are regarded to be an appealing complement to TMDs for biexciton sources. However, a progress towards biexciton emission in colloidal nanomaterials has been challenging largely by small binding energy and ultrafast non-radiative multiexciton recombination. Here, we demonstrate room-temperature biexciton emission in Cu-doped CdSe colloidal quantum wells (CQWs) under continuous-wave excitation with intensity as low as ~10 W/cm2. The characteristics of radiative biexciton states are investigated by their super linear emission with respect to excitation power, thermal stability and transient photophysics. The interaction between the quantum confined host carriers and the dopant ions increases biexciton binding energy by two folds compared to the undoped CQWs. Such strong binding energy together with suppressed Auger recombination and efficient, spectrally narrow photoluminescence in a quasi-2D semiconductor enables sustained biexciton emission at room temperature, providing a potential solution for efficient, scalable and stand-alone quantum devices., Comment: 11 pages, 5 Figures

Purpose: To validate the performance of a commercially-available, CE-certified deep learning (DL) system, RetCAD v.1.3.0 (Thirona, Nijmegen, The Netherlands), for the joint automatic detection of diabetic retinopathy (DR) and age-related macular degeneration (AMD) in color fundus (CF) images on a dataset with mixed presence of eye diseases. Methods: Evaluation of joint detection of referable DR and AMD was performed on a DR-AMD dataset with 600 images acquired during routine clinical practice, containing referable and non-referable cases of both diseases. Each image was graded for DR and AMD by an experienced ophthalmologist to establish the reference standard (RS), and by four independent observers for comparison with human performance. Validation was furtherly assessed on Messidor (1200 images) for individual identification of referable DR, and the Age-Related Eye Disease Study (AREDS) dataset (133821 images) for referable AMD, against the corresponding RS. Results: Regarding joint validation on the DR-AMD dataset, the system achieved an area under the ROC curve (AUC) of 95.1% for detection of referable DR (SE=90.1%, SP=90.6%). For referable AMD, the AUC was 94.9% (SE=91.8%, SP=87.5%). Average human performance for DR was SE=61.5% and SP=97.8%; for AMD, SE=76.5% and SP=96.1%. Regarding detection of referable DR in Messidor, AUC was 97.5% (SE=92.0%, SP=92.1%); for referable AMD in AREDS, AUC was 92.7% (SE=85.8%, SP=86.0%). Conclusions: The validated system performs comparably to human experts at simultaneous detection of DR and AMD. This shows that DL systems can facilitate access to joint screening of eye diseases and become a quick and reliable support for ophthalmological experts.

The interaction of a high velocity clump of gas has been described by the plasmon model, which considers balance between ram pressure and the internal stratified structure of the decelerated clump. In this paper we propose an analytical model to describe the mass loss of such a clump due the interaction with the environment, describing its influence on the plasmon dynamics. We carry out comparisons between an analytic model and axisymetric gasdynamic simulations of plasmon evolution. From our simulations we were able to find the values of the friction constants $\alpha$ and $\lambda$. Comparing with the complete analytic model from which we can infer the position and the mass loss of the clump as function of the clump's density and the environment ratio.

We present chemical abundance determinations of two H II regions in the dIrr galaxy Leo A, from GTC OSIRIS long-slit spectra. Both H II regions are of low excitation and seem to be ionised by stars later than O8V spectral type. In one of the H II regions we used the direct method: O$^{+2}$ ionic abundance was calculated using an electronic temperature determined from the [O III] $\lambda\lambda$4363/5007 line ratio; ionic abundances of O$^+$, N$^+$, and S$^+$ were calculated using a temperature derived from a parameterised formula. O, N and S total abundances were calculated using Ionisation Correction Factors from the literature for each element. Chemical abundances using strong-line methods were also determined, with similar results. For the second H II region, no electron temperature was determined thus the direct method cannot be used. We computed photoionisation structure models for both H II regions in order to determine their chemical composition from the best-fitted models. It is confirmed that Leo A in a very low metallicity galaxy, with 12+log(O/H)=7.4$\pm$0.2, log(N/O)=$-$1.6, and log(S/O)=$-$1.1. Emission lines of the only PN detected in Leo A were reanalysed and a photoionisation model was computed. This PN shows 12+log(O/H) very similar to the ones of the H II regions and a low N abundance, although its log(N/O) ratio is much larger than the values of the H II regions. Its central star seems to have had an initial mass lower than 2 M$_\odot$., Comment: Accepted in MNRAS

One of the simplest model of immune surveillance and neoplasia was proposed by Delisi and Resigno. Later Liu et al proved the existence of non-degenerate Takens-Bogdanov bifurcations defining a surface in the whole set of five positive parameters. In this paper we prove the existence of Bautin bifurcations completing the scenario of possible codimension two bifurcations that occur in this model. We give an interpretation of our results in terms of the three phases immunoediting theory:elimination, equilibrium and escape., Comment: 22 pages, 17 figures

We describe a new method for determining proper motions of extended objects, and a pipeline developed for the application of this method. We then apply this method to an analysis of four epochs of [S~II] HST images of the HH~1 jet (covering a period of $\sim 20$~yr). We determine the proper motions of the knots along the jet, and make a reconstruction of the past ejection velocity time-variability (assuming ballistic knot motions). This reconstruction shows an "acceleration" of the ejection velocities of the jet knots, with higher velocities at more recent times. This acceleration will result in an eventual merging of the knots in $\sim 450$~yr and at a distance of $\sim 80"$ from the outflow source, close to the present-day position of HH~1., Comment: 12 pages, 8 figures