51. Circulating white blood cells and lung function impairment: the observational studies and Mendelian randomization analysis
- Author
-
Xiulong Wu, Chenming Wang, Hang Li, Hua Meng, Jiali Jie, Ming Fu, Yansen Bai, Guyanan Li, Wei Wei, Yue Feng, Mengying Li, Xin Guan, Meian He, Xiaomin Zhang, and Huan Guo
- Subjects
Lung function ,white blood cell counts ,LASSO regression ,epidemiology ,Mendelian randomization ,Medicine - Abstract
AbstractBackground Circulating white blood cell (WBC) counts have been related to lung function impairment, but causal relationship was not established. We aimed to evaluate independent effects and causal relationships of WBC subtypes with lung function.Methods The 19,159 participants from NHANES 2011–2012 (n = 3570), coke-oven workers (COW, n = 1762) and Dongfeng-Tongji (DFTJ, n = 13,827) cohorts were included in the observational studies. The associations between circulating counts of WBC subtypes and prebronchodilator lung function were evaluated by linear regression models and LASSO regression was used to select effective WBC subtypes. Summary statistics for WBC-associated SNPs were extracted from literature, and Mendelian randomization (MR) analysis with inverse-variance weighted (IVW) method was applied to estimate the causal effects of total WBC and subtypes on lung function among 4012 subjects from COW (n = 1126) and DFTJ cohorts (n = 2886).Results Total WBC counts were negatively associated with lung function among three populations and their pooled analysis indicated that per 1 × 109 cells/L increase in total WBC was associated with 36.13 (95% CI: 30.35, 41.91) mL and 25.23 (95% CI: 19.97, 30.50) mL decrease in FVC and FEV1, respectively. Independent associations with lung function were found for neutrophils, monocytes, eosinophils and basophils (all p
- Published
- 2021
- Full Text
- View/download PDF