859 results on '"Hubbuch, Jürgen"'
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52. Feasibility of using continuous chromatography in downstream processing: Comparison of costs and product quality for a hybrid process vs. a conventional batch process
53. Corrigendum: Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions
54. Size-selective downstream processing of virus particles and non-enveloped virus-like particles
55. An adaptive soft‐sensor for advanced real‐time monitoring of an antibody‐drug conjugation reaction
56. Analytics in Extrusion-Based Bioprinting: Standardized Methods Improving Quantification and Comparability of the Performance of Bioinks
57. Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions
58. Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks
59. Orientation of monoclonal antibodies in ion-exchange chromatography: A predictive quantitative structure–activity relationship modeling approach
60. Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology
61. Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks
62. An orientation sensitive approach in biomolecule interaction quantitative structure–activity relationship modeling and its application in ion-exchange chromatography
63. Investigation and prediction of protein precipitation by polyethylene glycol using quantitative structure–activity relationship models
64. A mechanistic model of ion-exchange chromatography on polymer fiber stationary phases
65. Mechanical Properties of Protein-Based Hydrogels Derived from Binary Protein Mixtures—A Feasibility Study
66. Antibody Sequence-Based Prediction of Ph Gradient Elution in Multimodal Chromatography
67. Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography
68. High-throughput downstream process development for cell-based products using aqueous two-phase systems
69. Concentration-dependent changes in apparent diffusion coefficients as indicator for colloidal stability of protein solutions
70. Prediction of salt effects on protein phase behavior by HIC retention and thermal stability
71. Quantification of PEGylated proteases with varying degree of conjugation in mixtures: An analytical protocol combining protein precipitation and capillary gel electrophoresis
72. Impact of polymer surface characteristics on the microrheological measurement quality of protein solutions – A tracer particle screening
73. Application of spectral deconvolution and inverse mechanistic modelling as a tool for root cause investigation in protein chromatography
74. High-throughput characterization of virus-like particles by interlaced size-exclusion chromatography
75. High-throughput process development of an alternative platform for the production of virus-like particles in Escherichia coli
76. Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles
77. Manipulation of lysozyme phase behavior by additives as function of conformational stability
78. Effect of lysozyme solid-phase PEGylation on reaction kinetics and isoform distribution
79. Machine-assisted cultivation and analysis of biofilms
80. Custom-tailored adsorbers: A molecular dynamics study on optimal design of ion exchange chromatography material
81. Light extinction and scattering by agarose based resin beads and applications in high-throughput screening
82. Influence of binding pH and protein solubility on the dynamic binding capacity in hydrophobic interaction chromatography
83. Integrated development of up- and downstream processes supported by the Cherry-Tag™ for real-time tracking of stability and solubility of proteins
84. Robust high-throughput batch screening method in 384-well format with optical in-line resin quantification
85. Downstream processing of virus-like particles: Single-stage and multi-stage aqueous two-phase extraction
86. A comprehensive molecular dynamics approach to protein retention modeling in ion exchange chromatography
87. Determination of protein phase diagrams by microbatch experiments: Exploring the influence of precipitants and pH
88. Predicting recombinant protein expression experiments using molecular dynamics simulation
89. Calibration-free PAT: Locating selective crystallization or precipitation sweet spot in screenings with multi-way PARAFAC models
90. A Novel Approach for the Manufacturing of Gelatin-Methacryloyl
91. Systematic evaluation of agarose- and agar-based bioinks for extrusion-based bioprinting of enzymatically active hydrogels
92. Magnetic Resonance Imaging: Time-Dependent Wetting and Swelling Behavior of an Auxetic Hydrogel Based on Natural Polymers
93. A multiscale modeling method for therapeutic antibodies in ion exchange chromatography
94. Characterization of aqueous two phase systems by combining lab-on-a-chip technology with robotic liquid handling stations
95. Model-based integrated optimization and evaluation of a multi-step ion exchange chromatography
96. Changing mechanical properties of photopolymerized, dityrosine-crosslinked protein-based hydrogels
97. A Novel MATLAB®-Algorithm-Based Video Analysis to Quantitatively Determine Solution Creeping in Intact Pharmaceutical Glass Vials
98. Structured Data Storage for Data-Driven Process Optimisation in Bioprinting
99. Effects of Different Lengths of a Nucleic Acid Binding Region and Bound Nucleic Acids on the Phase Behavior and Purification Process of HBcAg Virus-Like Particles
100. Adjoint-based estimation and optimization for column liquid chromatography models
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