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56. Radiation therapy for locally advanced pancreatic adenocarcinoma: a therapeutic option which should not be forgotten. Letter to the Editor regarding: "Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up" by Huguet et al

Author

Huguet, F., Bouchart, C., Bruynzeel, A.M.E., Hawkins, M.A., Mukherjee, S., Nuyttens, J.J., Riou, O., Scorsetti, M., Versteijne, E., Loi, M., and Vendrely, V.

Subjects
*PANCREATIC cancer, *RADIOTHERAPY, *DIAGNOSIS, *ADENOCARCINOMA, *PANCREATIC tumors
Published
2024
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57. Tracheal Cancers

Author

Touboul, E., Huguet, F., Belkacémi, Yazid, editor, Mirimanoff, René-Olivier, editor, and Ozsahin, Mahmut, editor

Published
2010
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62. Repo-Man/PP1 SUMOylation mediates binding to lamin A and Serine 22 dephosphorylation

Author

Huguet, F, Gokhan, E, Foster, HA, Amin, HA, and Vagnarelli, P

Subjects
mitosis, animal structures, phosphorylation, protein phosphatase 1, embryonic structures, macromolecular substances, SUMOylation, lamin A
Abstract

Data accessibility. The microscopy data are available from the corre- sponding author upon request and will be released via Figshare. Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.5912878. ORCiD: Paola Vagnarelli, 0000-0002-0000-2271 Copyright © 2022 The Authors. Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit. Several kinases have been identified as responsible for these phosphorylations, but no protein phosphatase has been implicated in their reversal. One of the mitotic phosphosites in lamin A responsible for its dynamic behaviour is serine 22 (S22) which is de-phosphorylated during mitotic exit. Recent evidence has also linked the nuclear pool of lamin A S22ph in interphase to gene expression regulation. Previous work suggested that the phosphatase responsible for lamin A S22 de-phosphorylation is chromatin bound and interacts with lamin A via SUMO-SIM motives. We have previously reported that Repo-Man/protein phosphatase 1 (PP1) is a chromatin-associated phosphatase that regulates NE reformation. Here we propose that Repo-Man/PP1 phosphatase mediates lamin A S22 de-phosphorylation. We indeed show that depletion of Repo-Man leads to NE defects, causes hyperphosphorylation of lamin A S22 that can be rescued by a wild-type but not a SUMOylation-deficient mutant. Lamin A and Repo-Man interact in vivo and in vitro, and the interaction is mediated by SUMOylation. Moreover, the localization of Repo-Man/PP1 to the chromatin is essential for lamin A S22 de-phosphorylation. Wellcome Trust Investigator award 3 210742/Z/18/Z to Paola Vagnarelli.

Published
2022

67. P477: PHENOTYPICALLY-DEFINED STAGES OF LEUKEMIA ARREST PREDICT MAIN DRIVER MUTATIONS SUBGROUPS, AND OUTCOME IN ACUTE MYELOID LEUKEMIA

Author

Vergez, F., primary, Largeaud, L., additional, Bertoli, S., additional, Nicolau-Travers, M.-L., additional, Rieu, J.-B., additional, Vergnolle, I., additional, Saland, E., additional, Sarry, A., additional, Tavitian, S., additional, Huguet, F., additional, Picard, M., additional, Vial, J.-P., additional, Lechevalier, N., additional, Bidet, A., additional, Dumas, P.-Y., additional, Pigneux, A., additional, Luquet, I., additional, Mansat-De Mas, V., additional, Delabesse, E., additional, Carroll, M., additional, Danet-Desnoyers, G., additional, Sarry, J.-E., additional, and Recher, C., additional

Published
2022
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68. OC-0108 Impact of the Radiation Therapy Quality Assurance in the phase II/III CONCORDE trial.

Author

Lopez, H., primary, Créhange, G., additional, Blanc, J., additional, M'vondo, C., additional, Pereira, R., additional, Rio, E., additional, Peiffert, D., additional, Gnep, K., additional, Benezery, K., additional, Ronchin, P., additional, Noel, G., additional, Mineur, L., additional, Drouillard, A., additional, Rouffiac, M., additional, Boustani, J., additional, Bertaut, A., additional, and Huguet, F., additional

Published
2022
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69. MO-0226 Clinical outcomes of HIV-positive patients with anal cancer in the ANABASE multicentric cohort

Author

Evin, C., primary, Quéro, L., additional, Le Malicot, K., additional, Blanchet-Deverly, S., additional, François, E., additional, Buchalet, C., additional, Lemanski, C., additional, Baba Hamed, N., additional, Rivin del Campo, E., additional, Bauwens, L., additional, Pommier, P., additional, Lièvre, A., additional, Tougeron, D., additional, Macé, V., additional, Sergent, G., additional, Diaz, O., additional, Zucman, D., additional, Mornex, F., additional, Locher, C., additional, De la Rochefordière, A., additional, Vendrely, V., additional, and Huguet, F., additional

Published
2022
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78. Étude Raibeca : radiotherapy for inflammatory breast cancer

Author

Roge, M., primary, Salleron, J., additional, Kirova, Y., additional, Guigo, M., additional, Huguet, F., additional, Nebbache, R., additional, Rivera, S., additional, Nunez Baez, M., additional, Lazarescu, I., additional, Servagi Vernat, S., additional, Cailleteau, A., additional, Supiot, S., additional, Thariat, J., additional, and Thureau, S., additional

Published
2021
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79. Efficacité et toxicité de la (chimio)radiothérapie chez les patients séropositifs pour le VIH atteints d’un carcinome épidermoïde du canal anal, analyse en sous-groupe de la cohorte multicentrique Anabase

Author

Evin, C., primary, Quéro, L., additional, Le Malicot, K., additional, Blanchet-Deverly, S., additional, François, E., additional, Buchalet, C., additional, Lemanski, C., additional, Baba Hamed, N., additional, Rivin Del Campo, E., additional, Bauwens, L., additional, Pommier, P., additional, Lièvre, A., additional, Tougeron, D., additional, Mace, V., additional, Sergent, G., additional, Diaz, O., additional, Zucman, D., additional, Mornex, F., additional, Locher, C., additional, de La Rochefordiere, A., additional, Vendrely, V., additional, and Huguet, F., additional

Published
2021
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80. Évaluation du questionnement éthique en radiothérapie

Author

Leseur, J., primary, Créhange, G., additional, Pasquier, D., additional, Supiot, S., additional, Pommier, P., additional, Latorzeff, I., additional, Blanchard, P., additional, Mahé, M., additional, Sargos, P., additional, Colliaux, J., additional, Huguet, F., additional, Haaser, T., additional, Clavère, P., additional, Peiffert, D., additional, Lartigau, É., additional, Giraud, P., additional, Noël, G., additional, Simon, J.-M., additional, Hasbini, A., additional, Chauveinc, L., additional, Hennequin, C., additional, Lagrange, J.L., additional, and de Crevoisier, R., additional

Published
2021
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81. Prospective Study Comparing Idarubicin and Daunorubicin in Elderly Patients with Acute Myeloid Leukemia

Author

Reiffers, J., Rigal-Huguet, F., Stoppa, A. M., Michallet, M., Marit, G., Attal, M., Gastaut, J. A., Corront, B., Lepeu, G., Routy, M., Cony-Makhoul, P., Pris, J., Hollard, D., Maraninchi, D., Mercier, M., Hurteloup, P., Hiddemann, W., editor, Büchner, T., editor, Wörmann, B., editor, Plunkett, W., editor, Keating, M., editor, and Andreeff, M., editor

Published
1992
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85. PO-1263 Exclusive radiotherapy in early stage anal cancer - outcomes, patterns and predictors of relapse

Author

Briens, A., primary, Neuzillet, C., additional, Huguet, F., additional, Rivin Del Campo, E., additional, Guimas, V., additional, Fallet, E., additional, Garcia Molina, S., additional, François, E., additional, Montagne, L., additional, Schick, U., additional, Lesueur, P., additional, Siphroudis, L., additional, Edeline, J., additional, Castelli, J., additional, de Crevoisier, R., additional, Lièvre, A., additional, and Gnep, K., additional

Published
2021
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89. Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL

Author

Garand, R, Beldjord, K, Cavé, H, Fossat, C, Arnoux, I, Asnafi, V, Bertrand, Y, Boulland, M-L, Brouzes, C, Clappier, E, Delabesse, E, Fest, T, Garnache-Ottou, F, Huguet, F, Jacob, M-C, Kuhlein, E, Marty-Grès, S, Plesa, A, Robillard, N, Roussel, M, Tkaczuk, J, Dombret, H, Macintyre, E, Ifrah, N, Béné, M C, and Baruchel, A

Published
2013
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97. PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

Author

Familiades, J, Bousquet, M, Lafage-Pochitaloff, M, Béné, M-C, Beldjord, K, De Vos, J, Dastugue, N, Coyaud, E, Struski, S, Quelen, C, Prade-Houdellier, N, Dobbelstein, S, Cayuela, J-M, Soulier, J, Grardel, N, Preudhomme, C, Cavé, H, Blanchet, O, Lhéritier, V, Delannoy, A, Chalandon, Y, Ifrah, N, Pigneux, A, Brousset, P, Macintyre, E A, Huguet, F, Dombret, H, Broccardo, C, and Delabesse, É

Published
2009
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