51. Successful Surgical Treatment of Severe Calciphylaxis Using a Bilayer Dermal Replacement Matrix.
- Author
-
Solanky D, Hwang SM, Stone G, Gillenwater J, and Carey JN
- Subjects
- Adult, Calciphylaxis complications, Calciphylaxis physiopathology, Combined Modality Therapy, Comorbidity, Disease Progression, Female, Humans, Liver Diseases complications, Liver Function Tests, Necrosis pathology, Negative-Pressure Wound Therapy methods, Renal Insufficiency complications, Skin pathology, Thigh pathology, Thigh surgery, Treatment Outcome, Wound Healing, Calciphylaxis surgery, Debridement methods, Liver Diseases physiopathology, Necrosis surgery, Renal Insufficiency physiopathology, Skin blood supply, Skin Transplantation methods, Thigh blood supply
- Abstract
Cutaneous calciphylaxis is a rare and often intractable disease that involves subcutaneous vascular calcification, ischemia, and subsequent necrosis. Calciphylaxis has an associated 60%-80% mortality rate with sepsis as the leading cause of death. However, despite variable success rates, the proper treatment of calciphylaxis remains controversial. In this case report, the authors present a 42-year-old female who presented with bilateral lower extremity calciphylaxis in conjunction with long-standing liver disease and acute renal failure. Cure of the patient's calciphylaxis was achieved through a surgical approach using staged debridement, placement of a dermal regenerative template (Integra Dermal Regeneration Template, Integra Lifesciences, Plainsboro, NJ), and followed by successful skin grafting. This is the first successful treatment of calciphylaxis in the literature to date using dermal regenerative template material.
- Published
- 2015