Search

Your search keyword '"Inukai, T."' showing total 846 results
Start Over Author "Inukai, T."
846 results on '"Inukai, T."'

52. Efficient manufacturing system implementation based on combination between real and virtual factory.

Author

Hibino, H., Inukai, T., and Fukuda, Y.

Subjects
FACTORY design & construction, VIRTUAL reality in management, COMPUTER integrated manufacturing systems, PRODUCTION engineering, FACTORY management, PROCESS control systems, COMPUTER simulation, RESEARCH methodology
Abstract

At present, before real factories are implemented on the shop floor, methods to evaluate facility control programs for equipment, such as ladder programs for programmable logic controllers (PLC) while mixing and synchronizing real equipment and virtual factory models on the computers, have not been developed. Digital data as virtual factory models which are defined at a design stage cannot be re-used at an implementation stage. These difficulties stop precise and rapid support of a manufacturing system engineering process from the design stage to the implementation stage. In this paper, an intermediation environment to connect real factories and virtual factories is first proposed. This environment consists of a distributed real manufacturing simulation environment (DRMSE) and a distributed simulation environment (DSE). Then DRMSE, which creates evaluating facility control programs while mixing and synchronizing real equipment and virtual factory models before real factories are implemented, is proposed in detail. Production facilities simulators which simulate facility behaviours using signals and data from a real world, and a soft-wiring system which logically wire real world data and simulation world data on the production facilities simulator, are proposed in DRMSE. Finally work was carried out to evaluate the performance of cooperative work. [ABSTRACT FROM AUTHOR]

Published
2006
Full Text
View/download PDF

53. Assessment of Waist Circumference Index as a New Screening Parameter for Pre-Metabolic Syndrome

Author

Otsu H, Nishikata H, Ohba T, Morino K, Tokutake E, Aida K, Inukai T, Shuto C, Suzuki H, Tatsuro Inoue, Aoki N, Shuto H, Matsuo H, Sakai H, and Kiyomatsu Y

Subjects
medicine.medical_specialty, Index (economics), Waist, Intra-Abdominal Fat, business.industry, Odds ratio, Circumference, medicine.disease, Bioinformatics, Blood pressure, Internal medicine, medicine, Cardiology, Metabolic syndrome, business, Body mass index
Abstract

Aim: The concept of metabolic syndrome (MetS) is useful in encouraging modification of patient’s lifestyle. In order to detect prophase in MetS (pre-MetS), we evaluated waist circumference index (WCI) that was calculated by division of waist circumference (WC) by height in meter squared. Methods: A multiple logistic regression analysis was performed a the prevalence of risk factors for MetS (high blood pressure, abnormal lipid metabolism, high blood glucose) and age, WC, body mass index, WCI and intraabdominal fat area (IAFA) in 111 subjects in whom IAFA was measured at umbilicus level by CT scan. Results: WCI was the second most strongly correlated factor with the prevalence of risk factors after IAFA in terms of P values, and according to the odds ratios WCI was the most significantly correlated. Conclusion: The results suggested that the WCI might be capable of serving as an index that can substitute for a CT scan as a means of detecting pre-MetS.

Published
2015

55. Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children

Author

Kato, M, primary, Ishimaru, S, additional, Seki, M, additional, Yoshida, K, additional, Shiraishi, Y, additional, Chiba, K, additional, Kakiuchi, N, additional, Sato, Y, additional, Ueno, H, additional, Tanaka, H, additional, Inukai, T, additional, Tomizawa, D, additional, Hasegawa, D, additional, Osumi, T, additional, Arakawa, Y, additional, Aoki, T, additional, Okuya, M, additional, Kaizu, K, additional, Kato, K, additional, Taneyama, Y, additional, Goto, H, additional, Taki, T, additional, Takagi, M, additional, Sanada, M, additional, Koh, K, additional, Takita, J, additional, Miyano, S, additional, Ogawa, S, additional, Ohara, A, additional, Tsuchida, M, additional, and Manabe, A, additional

Published
2016
Full Text
View/download PDF

56. Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor

Author

Christine E. Canman, T Inaba, Richard A. Ashmun, Seyschab H, A T Look, Inukai T, Michael B. Kastan, Laken Sj, and T Yoshihara

Subjects
Leucine zipper, Oncogene Proteins, Fusion, Molecular Sequence Data, Apoptosis, Chromosomal translocation, Biology, Translocation, Genetic, Cell Line, Fusion gene, Mice, Transcription (biology), Tumor Cells, Cultured, Animals, Humans, Amino Acid Sequence, Transcription factor, B-Lymphocytes, Leucine Zippers, Multidisciplinary, Cell growth, Cell Cycle, DNA, Molecular biology, Fusion protein, DNA-Binding Proteins, Zinc, Basic-Leucine Zipper Transcription Factors, Mutation, Interleukin-3, Tumor Suppressor Protein p53, Chromosomes, Human, Pair 19, Cell Division, Chromosomes, Human, Pair 17, Transcription Factors
Abstract

THE E2A–HLF (for hepatic leukaemia factor) fusion gene, formed by action of the t(17;19) (q22;p13) chromosomal translocation, drives the leukaemic transformation of early B-cell precursors1–4, but the mechanism of this activity remains unknown. Here we report that human leukaemia cells carrying the translocation t(17;19) rapidly died by apoptosis when programmed to express a dominant-negative suppressor of the fusion protein E2A–HLF, indicating that the chimaeric oncoprotein probably affects cell survival rather than cell growth. Moreover, when introduced into murine pro-B lymphocytes, the oncogenic E2A–HLF fusion protein reversed both interleukin-3-dependent and p53-mediated apoptosis. The close homology of the basic region/leucine zipper (bZIP) DNA-binding and dimerization domain of HLF to that of the CES-2 cell-death specification protein of Caenorhabditis elegans5 suggests a model of leukaemogenesis in which E2A–HLF blocks an early step within an evolutionarily conserved cell-death pathway6–9.

Published
1996

58. The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells

Author

Ra, Altura, Inukai T, Ra, Ashmun, Gp, Zambetti, Martine F. Roussel, and At, Look

Subjects
Cyclin-Dependent Kinase Inhibitor p21, Oncogene Proteins, Fusion, Transcription, Genetic, Recombinant Fusion Proteins, Apoptosis, Mice, Cyclins, Proto-Oncogene Proteins, Consensus Sequence, Tumor Cells, Cultured, Animals, bcl-2-Associated X Protein, Binding Sites, Gene Expression Regulation, Leukemic, Interleukin-6, Temperature, DNA, Neoplasm, Genes, p53, Neoplasm Proteins, DNA-Binding Proteins, Basic-Leucine Zipper Transcription Factors, G-Box Binding Factors, Proto-Oncogene Proteins c-bcl-2, Leukemia, Myeloid, Tumor Suppressor Protein p53, DNA Damage, Protein Binding, Transcription Factors
Abstract

Leukemic lymphoblasts expressing the E2A-HLF oncoprotein possess wild-type p53 genes, but do not undergo apoptosis in response to DNA damage. Experimentally, E2A-HLF prevents apoptosis due to growth factor deprivation or gamma-irradiation in interleukin-3 (IL-3)-dependent murine pro-B cells. To directly test the chimeric protein's ability to abrogate p53-mediated cell death, we used mouse myeloid leukemia cells (M1p53tsval) that constitutively express a temperature-sensitive (ts) mutant p53 gene and undergo apoptosis when p53 assumes an active wild-type configuration. This effect is blocked by treatment with IL-6, which allows the cells to survive in culture despite wild-type p53 activation. We introduced E2A-HLF into M1p53tsval cells and found that they were resistant to p53-mediated apoptosis and that E2A-HLF effectively substituted for the survival functions of IL-6. The expression of p53-responsive genes such as p21 and Bax was upregulated normally, suggesting that E2A-HLF acts downstream of p53 to block execution of the p53-induced apoptotic program. NFIL3, a growth factor-regulated bZIP protein that binds to the same DNA-consensus site as E2A-HLF, delays apoptosis in IL-3-dependent pro-B cells deprived of growth factor. By contrast, in the present study, enforced expression of NFIL3 failed to protect M1p53tsval cells from p53-dependent apoptosis and actively antagonized the ability of IL-6 to rescue cells from that fate, consistent with its role as either a transcriptional repressor or activator, depending on the cell type in which it is expressed. We conclude that the E2A-HLF chimera abrogates p53-induced apoptosis in leukemic cells, possibly through the transcriptional modulation of cell death pathways that are activated by p53 in response to DNA damage.

Published
1998

62. BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia

Author

Kuroda, I, primary, Inukai, T, additional, Zhang, X, additional, Kikuchi, J, additional, Furukawa, Y, additional, Nemoto, A, additional, Akahane, K, additional, Hirose, K, additional, Honna-Oshiro, H, additional, Goi, K, additional, Kagami, K, additional, Yagita, H, additional, Tauchi, T, additional, Maeda, Y, additional, and Sugita, K, additional

Published
2012
Full Text
View/download PDF

64. Fine mapping of major genes for blast resistance in rice

Author

Mew, T. W., Parco, A., Hittalmani, S., Inukai, T., Nelson, R., Zeigler, R. S., and Huang, N.

Subjects
Gene Mapping, Blast, Disease Resistance
Abstract

This article 'Fine Mapping of Major Genes for Blast Resistance in Rice' appeared in the International Rice Research Notes series, created by the International Rice Research Institute (IRRI) to expedite communication among scientists concerned with the development of improved technology for rice and rice-based systems. The series is a mechanism to help scientists keep each other informed of current rice research findings. The concise scientific notes are meant to encourage rice scientists to communicate with one another to obtain details on the research reported.

Published
1994
Full Text
View/download PDF

69. Allelism between blast (BI) resistance genes Pi-4a(t) and Pi-ta

Author

Inukai, T., Nelson, R., Sarkarung, S., and Zeigler, R. S.

Subjects
Blast Resistance Genes, Allelism
Abstract

This article 'Allelism between blast (BI) resistance genes Pi-4a(t) and Pi-ta' appeared in the International Rice Research Notes series, created by the International Rice Research Institute (IRRI) to expedite communication among scientists concerned with the development of improved technology for rice and rice-based systems. The series is a mechanism to help scientists keep each other informed of current rice research findings. The concise scientific notes are meant to encourage rice scientists to communicate with one another to obtain details on the research reported., IRRI publication.

Published
1993
Full Text
View/download PDF

78. ACTS TDMA network control

Author

Inukai, T and Campanella, S. J

Subjects
Communications And Radar
Abstract

This paper presents basic network control concepts for the Advanced Communications Technology Satellite (ACTS) System. Two experimental systems, called the low-burst-rate and high-burst-rate systems, along with ACTS ground system features, are described. The network control issues addressed include frame structures, acquisition and synchronization procedures, coordinated station burst-time plan and satellite-time plan changes, on-board clock control based on ground drift measurements, rain fade control by means of adaptive forward-error-correction (FEC) coding and transmit power augmentation, and reassignment of channel capacities on demand. The NASA ground system, which includes a primary station, diversity station, and master control station, is also described.

Published
1984

79. Planning assistance for the NASA 30/20 GHz program. Network control architecture study.

Author

Inukai, T, Bonnelycke, B, and Strickland, S

Subjects
Communications And Radar
Abstract

Network Control Architecture for a 30/20 GHz flight experiment system operating in the Time Division Multiple Access (TDMA) was studied. Architecture development, identification of processing functions, and performance requirements for the Master Control Station (MCS), diversity trunking stations, and Customer Premises Service (CPS) stations are covered. Preliminary hardware and software processing requirements as well as budgetary cost estimates for the network control system are given. For the trunking system control, areas covered include on board SS-TDMA switch organization, frame structure, acquisition and synchronization, channel assignment, fade detection and adaptive power control, on board oscillator control, and terrestrial network timing. For the CPS control, they include on board processing and adaptive forward error correction control.

Published
1982

80. Little impact of donor/recipient major mismatch for neutrophil-specific antigen NA2 on neutrophil recovery after allogeneic SCT

Author

Inukai, T, primary, Goi, K, additional, Tezuka, T, additional, Uno, K, additional, Nemoto, A, additional, Takahashi, K, additional, Sato, H, additional, Akahane, K, additional, Hirose, K, additional, Honna, H, additional, Kuroda, I, additional, Kagami, K, additional, Nakamoto, K, additional, Taniguchi, K, additional, Nakazawa, S, additional, and Sugita, K, additional

Published
2008
Full Text
View/download PDF

84. Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19

Author

Inukai, T, primary, Hirose, K, additional, Inaba, T, additional, Kurosawa, H, additional, Hama, A, additional, Inada, H, additional, Chin, M, additional, Nagatoshi, Y, additional, Ohtsuka, Y, additional, Oda, M, additional, Goto, H, additional, Endo, M, additional, Morimoto, A, additional, Imaizumi, M, additional, Kawamura, N, additional, Miyajima, Y, additional, Ohtake, M, additional, Miyaji, R, additional, Saito, M, additional, Tawa, A, additional, Yanai, F, additional, Goi, K, additional, Nakazawa, S, additional, and Sugita, K, additional

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results