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51. Quality of life and its association with work, the Internet, participation in groups and physical activity among the elderly from the EpiFloripa survey, Florianópolis, Santa Catarina State, Brazil

Author: Larissa Pruner Marques, Ione Jayce Ceola Schneider, and Eleonora d'Orsi
Subjects: Qualidade de Vida, Idoso, Rede Social, Atividade Motora, Medicine, Public aspects of medicine, RA1-1270
Abstract: Abstract: The study aimed to investigate the association between changes in social relations and physical activity on the quality of life of the elderly in the city of Florianópolis, Santa Catarina state, Brazil. Data on 1,197 elderly from two waves of the population and household survey, EpiFloripa Idoso, were analyzed. Multiple linear regression was performed to estimate association of social change variables and lifestyle on quality of life score (QoL; measured by CASP-16 Brazil, score can range from 0, which represents no QoL to 48, total satisfaction in all domains of CASP). The average QoL score in the sample was 37.6 (95%CI: 37.2; 38.1). The social relations that were associated with positive QoL score were to start to work, to continue to use the Internet, to start participating in religious or lifestyle groups, to remain and to become physically active, and for those who were physically active, but became inactive in the second wave. To remain living with family had a negative effect on QoL score for the elderly. Some changes in social relations had a positive effect on QoL, and results reaffirmed the importance of physical activity to healthy aging, since to pursue it in some of the waves was better than to remain inactive.
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52. Impacto da vacinação contra influenza em idosos no Brasil

Author: Alana Patrício Stols Cruzeta, Ione Jayce Ceola Schneider, and Jefferson Traebert
Subjects: Medicine, Public aspects of medicine, RA1-1270
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53. Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Rajesh Sharma, Mohsen Abbasi-Kangevari, Rami Abd-Rabu, Hassan Abidi, Eman Abu-Gharbieh, Juan Manuel Acuna, Sangeet Adhikari, Shailesh M Advani, Muhammad Sohail Afzal, Mohamad Aghaie Meybodi, Bright Opoku Ahinkorah, Sajjad Ahmad, Ali Ahmadi, Sepideh Ahmadi, Haroon Ahmed, Luai A Ahmed, Muktar Beshir Ahmed, Hanadi Al Hamad, Fares Alahdab, Fahad Mashhour Alanezi, Turki M Alanzi, Fadwa Alhalaiqa Naji Alhalaiqa, Yousef Alimohamadi, Vahid Alipour, Syed Mohamed Aljunid, Motasem Alkhayyat, Sami Almustanyir, Rajaa M Al-Raddadi, Saba Alvand, Nelson Alvis-Guzman, Saeed Amini, Robert Ancuceanu, Amir Anoushiravani, Ali Arash Anoushirvani, Alireza Ansari-Moghaddam, Jalal Arabloo, Armin Aryannejad, Mohammad Asghari Jafarabadi, Seyyed Shamsadin Athari, Floriane Ausloos, Marcel Ausloos, Atalel Fentahun Awedew, Mamaru Ayenew Awoke, Tegegn Mulatu Ayana, Sina Azadnajafabad, Hiva Azami, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Ashish D Badiye, Sara Bagherieh, Saeed Bahadory, Atif Amin Baig, Jennifer L Baker, Maciej Banach, Amadou Barrow, Alemshet Yirga Berhie, Sima Besharat, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Krittika Bhattacharyya, Vijayalakshmi S Bhojaraja, Sadia Bibi, Ali Bijani, Antonio Biondi, Tone Bjørge, Belay Boda Abule Bodicha, Dejana Braithwaite, Hermann Brenner, Daniela Calina, Chao Cao, Yin Cao, Giulia Carreras, Felix Carvalho, Ester Cerin, Raja Chandra Chakinala, William C S Cho, Dinh-Toi Chu, Joao Conde, Vera Marisa Costa, Natália Cruz-Martins, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Anna Danielewicz, Feleke Mekonnen Demeke, Getu Debalkie Demissie, Rupak Desai, Deepak Dhamnetiya, Mostafa Dianatinasab, Daniel Diaz, Mojtaba Didehdar, Saeid Doaei, Linh Phuong Doan, Milad Dodangeh, Fatemeh Eghbalian, Debela Debela Ejeta, Michael Ekholuenetale, Temitope Cyrus Ekundayo, Iman El Sayed, Muhammed Elhadi, Daniel Berhanie Enyew, Tahir Eyayu, Rana Ezzeddini, Ildar Ravisovich Fakhradiyev, Umar Farooque, Hossein Farrokhpour, Farshad Farzadfar, Ali Fatehizadeh, Hamed Fattahi, Nima Fattahi, Masood Fereidoonnezhad, Eduarda Fernandes, Getahun Fetensa, Irina Filip, Florian Fischer, Masoud Foroutan, Peter Andras Gaal, Mohamed M Gad, Silvano Gallus, Tushar Garg, Tamiru Getachew, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Nermin Ghith, Maryam Gholamalizadeh, Jamshid Gholizadeh Navashenaq, Abraham Tamirat Gizaw, James C Glasbey, Mahaveer Golechha, Pouya Goleij, Kebebe Bekele Gonfa, Giuseppe Gorini, Avirup Guha, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Nima Hafezi-Nejad, Arvin Haj-Mirzaian, Rabih Halwani, Shafiul Haque, Sanam Hariri, Ahmed I Hasaballah, Soheil Hassanipour, Simon I Hay, Claudiu Herteliu, Ramesh Holla, Mohammad-Salar Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Mowafa Househ, Junjie Huang, Ayesha Humayun, Ivo Iavicoli, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Farhad Islami, Masao Iwagami, Mohammad Ali Jahani, Mihajlo Jakovljevic, Tahereh Javaheri, Ranil Jayawardena, Rime Jebai, Ravi Prakash Jha, Tamas Joo, Nitin Joseph, Farahnaz Joukar, Jacek Jerzy Jozwiak, Ali Kabir, Rohollah Kalhor, Ashwin Kamath, Neeti Kapoor, Ibraheem M Karaye, Amirali Karimi, Joonas H Kauppila, Asma Kazemi, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Rovshan Khalilov, Javad Khanali, Maryam Khayamzadeh, Mahmoud Khodadost, Hanna Kim, Min Seo Kim, Adnan Kisa, Sezer Kisa, Ali-Asghar Kolahi, Hamid Reza Koohestani, Jacek A Kopec, Rajasekaran Koteeswaran, Ai Koyanagi, Yuvaraj Krishnamoorthy, G Anil Kumar, Manoj Kumar, Vivek Kumar, Carlo La Vecchia, Faris Hasan Lami, Iván Landires, Caterina Ledda, Sang-woong Lee, Wei-Chen Lee, Yeong Yeh Lee, Elvynna Leong, Bingyu Li, Stephen S Lim, Stany W Lobo, Joana A Loureiro, Raimundas Lunevicius, Farzan Madadizadeh, Ata Mahmoodpoor, Azeem Majeed, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Fariborz Mansour-Ghanaei, Lorenzo Giovanni Mantovani, Miquel Martorell, Sahar Masoudi, Prashant Mathur, Jitendra Kumar Meena, Entezar Mehrabi Nasab, Walter Mendoza, Alexios-Fotios A Mentis, Tomislav Mestrovic, Junmei Miao Jonasson, Bartosz Miazgowski, Tomasz Miazgowski, Gelana Fekadu Worku Mijena, Seyyedmohammadsadeq Mirmoeeni, Mohammad Mirza-Aghazadeh-Attari, Hamed Mirzaei, Sanjeev Misra, Karzan Abdulmuhsin Mohammad, Esmaeil Mohammadi, Saeed Mohammadi, Seyyede Momeneh Mohammadi, Abdollah Mohammadian-Hafshejani, Shafiu Mohammed, Teroj Abdulrahman Mohammed, Nagabhishek Moka, Ali H Mokdad, Zeinab Mokhtari, Mariam Molokhia, Sara Momtazmanesh, Lorenzo Monasta, Ghobad Moradi, Rahmatollah Moradzadeh, Paula Moraga, Joana Morgado-da-Costa, Sumaira Mubarik, Francesk Mulita, Mohsen Naghavi, Mukhammad David Naimzada, Hae Sung Nam, Zuhair S Natto, Biswa Prakash Nayak, Javad Nazari, Ehsan Nazemalhosseini-Mojarad, Ionut Negoi, Cuong Tat Nguyen, Son Hoang Nguyen, Nurulamin M Noor, Maryam Noori, Seyyed Mohammad Ali Noori, Virginia Nuñez-Samudio, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Oluwakemi Ololade Odukoya, Ayodipupo Sikiru Oguntade, Hassan Okati-Aliabad, Andrew T Olagunju, Tinuke O Olagunju, Sokking Ong, Samuel M Ostroff, Alicia Padron-Monedero, Reza Pakzad, Adrian Pana, Anamika Pandey, Fatemeh Pashazadeh Kan, Urvish K Patel, Uttam Paudel, Renato B Pereira, Navaraj Perumalsamy, Richard G Pestell, Zahra Zahid Piracha, Richard Charles G Pollok, Akram Pourshams, Naeimeh Pourtaheri, Akila Prashant, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Sima Rafiei, Mosiur Rahman, Amir Masoud Rahmani, Vahid Rahmanian, Nazanin Rajai, Aashish Rajesh, Vajiheh Ramezani-Doroh, Kiana Ramezanzadeh, Kamal Ranabhat, Sina Rashedi, Amirfarzan Rashidi, Mahsa Rashidi, Mohammad-Mahdi Rashidi, Mandana Rastegar, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Andre M N Renzaho, Negar Rezaei, Nima Rezaei, Saeid Rezaei, Mohsen Rezaeian, Sahba Rezazadeh-Khadem, Gholamreza Roshandel, Maha Mohamed Saber-Ayad, Bahar Saberzadeh-Ardestani, Basema Saddik, Hossein Sadeghi, Umar Saeed, Maryam Sahebazzamani, Amirhossein Sahebkar, Amir Salek Farrokhi, Amir Salimi, Hamideh Salimzadeh, Pouria Samadi, Mehrnoosh Samaei, Abdallah M Samy, Juan Sanabria, Milena M Santric-Milicevic, Muhammad Arif Nadeem Saqib, Arash Sarveazad, Brijesh Sathian, Maheswar Satpathy, Ione Jayce Ceola Schneider, Mario Šekerija, Sadaf G Sepanlou, Allen Seylani, Feng Sha, Sayed Mohammad Shafiee, Zahra Shaghaghi, Saeed Shahabi, Elaheh Shaker, Maedeh Sharifian, Javad Sharifi-Rad, Sara Sheikhbahaei, Jeevan K Shetty, Reza Shirkoohi, Parnian Shobeiri, Sudeep K Siddappa Malleshappa, Diego Augusto Santos Silva, Guilherme Silva Julian, Achintya Dinesh Singh, Jasvinder A Singh, Md Shahjahan Siraj, Gholam Reza Sivandzadeh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Bogdan Socea, Marco Solmi, Mohammad Sadegh Soltani-Zangbar, Suhang Song, Viktória Szerencsés, Miklós Szócska, Rafael Tabarés-Seisdedos, Elnaz Tabibian, Majid Taheri, Yasaman TaheriAbkenar, Amir Taherkhani, Iman M Talaat, Ker-Kan Tan, Abdelghani Tbakhi, Bekele Tesfaye, Amir Tiyuri, Daniel Nigusse Tollosa, Mathilde Touvier, Bach Xuan Tran, Biruk Shalmeno Tusa, Irfan Ullah, Saif Ullah, Marco Vacante, Sahel Valadan Tahbaz, Massimiliano Veroux, Bay Vo, Theo Vos, Cong Wang, Ronny Westerman, Melat Woldemariam, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Fereshteh Yazdanpanah, Chuanhua Yu, Deniz Yuce, Ismaeel Yunusa, Vesna Zadnik, Mazyar Zahir, Iman Zare, Zhi-Jiang Zhang, Mohammad Zoladl, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Sharma, Rajesh, Abbasi-Kangevari, Mohsen, Abd-Rabu, Rami, Abidi, Hassan, Ahmed, Muktar Beshir, Zoladl, Mohammad, GBD 2019 Colorectal Cancer Collaborators, Sharma, R, Abbasi-Kangevari, M, Abd-Rabu, R, Abidi, H, Abu-Gharbieh, E, Manuel Acuna, J, Adhikari, S, M Advani, S, Sohail Afzal, M, Aghaie Meybodi, M, Opoku Ahinkorah, B, Ahmad, S, Ahmadi, A, Ahmadi, S, Ahmed, H, A Ahmed, L, Beshir Ahmed, M, Al Hamad, H, Alahdab, F, Mashhour Alanezi, F, M Alanzi, T, Alhalaiqa Naji Alhalaiqa, F, Alimohamadi, Y, Alipour, V, Mohamed Aljunid, S, Alkhayyat, M, Almustanyir, S, M Al-Raddadi, R, Alvand, S, Alvis-Guzman, N, Amini, S, Ancuceanu, R, Anoushiravani, A, Arash Anoushirvani, A, Ansari-Moghaddam, A, Arabloo, J, Aryannejad, A, Asghari Jafarabadi, M, Shamsadin Athari, S, Ausloos, F, Ausloos, M, Fentahun Awedew, A, Ayenew Awoke, M, Mulatu Ayana, T, Azadnajafabad, S, Azami, H, Azangou-Khyavy, M, Azari Jafari, A, D Badiye, A, Bagherieh, S, Bahadory, S, Amin Baig, A, L Baker, J, Banach, M, Barrow, A, Yirga Berhie, A, Besharat, S, S Bhagat, D, Srikanth Bhagavathula, A, Bhala, N, Bhattacharyya, K, S Bhojaraja, V, Bibi, S, Bijani, A, Biondi, A, Bj??rge, T, Boda Abule Bodicha, B, Braithwaite, D, Brenner, H, Calina, D, Cao, C, Cao, Y, Carreras, G, Carvalho, F, Cerin, E, Chandra Chakinala, R, S Cho, W, Chu, D, Conde, J, Marisa Costa, V, Cruz-Martins, N, Dadras, O, Dai, X, Dandona, L, Dandona, R, Danielewicz, A, Mekonnen Demeke, F, Debalkie Demissie, G, Desai, R, Dhamnetiya, D, Dianatinasab, M, Diaz, D, Didehdar, M, Doaei, S, Phuong Doan, L, Dodangeh, M, Eghbalian, F, Debela Ejeta, D, Ekholuenetale, M, Cyrus Ekundayo, T, El Sayed, I, Elhadi, M, Berhanie Enyew, D, Eyayu, T, Ezzeddini, R, Ravisovich Fakhradiyev, I, Farooque, U, Farrokhpour, H, Farzadfar, F, Fatehizadeh, A, Fattahi, H, Fattahi, N, Fereidoonnezhad, M, Fernandes, E, Fetensa, G, Filip, I, Fischer, F, Foroutan, M, Andras Gaal, P, M Gad, M, Gallus, S, Garg, T, Getachew, T, Ghamari, S, Ghashghaee, A, Ghith, N, Gholamalizadeh, M, Gholizadeh Navashenaq, J, Tamirat Gizaw, A, C Glasbey, J, Golechha, M, Goleij, P, Bekele Gonfa, K, Gorini, G, Guha, A, Gupta, S, Bala Gupta, V, Kumar Gupta, V, Haddadi, R, Hafezi-Nejad, N, Haj-Mirzaian, A, Halwani, R, Haque, S, Hariri, S, I Hasaballah, A, Hassanipour, S, I Hay, S, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Stephen Ilesanmi, O, M Ilic, I, D Ilic, M, Islami, F, Iwagami, M, Ali Jahani, M, Jakovljevic, M, Javaheri, T, Jayawardena, R, Jebai, R, Prakash Jha, R, Joo, T, Joseph, N, Joukar, F, Jerzy Jozwiak, J, Kabir, A, Kalhor, R, Kamath, A, Kapoor, N, M Karaye, I, Karimi, A, H Kauppila, J, Kazemi, A, Keykhaei, M, Saleh Khader, Y, Khajuria, H, Khalilov, R, Khanali, J, Khayamzadeh, M, Khodadost, M, Kim, H, Seo Kim, M, Kisa, A, Kisa, S, Kolahi, A, Reza Koohestani, H, A Kopec, J, Koteeswaran, R, Koyanagi, A, Krishnamoorthy, Y, Anil Kumar, G, Kumar, M, Kumar, V, La Vecchia, C, Hasan Lami, F, Landires, I, Ledda, C, Lee, S, Lee, W, Yeh Lee, Y, Leong, E, Li, B, S Lim, S, W Lobo, S, A Loureiro, J, Lunevicius, R, Madadizadeh, F, Mahmoodpoor, A, Majeed, A, Malekpour, M, Malekzadeh, R, Azam Malik, A, Mansour-Ghanaei, F, Mantovani, L, Martorell, M, Masoudi, S, Mathur, P, Kumar Meena, J, Mehrabi Nasab, E, Mendoza, W, A Mentis, A, Mestrovic, T, Miao Jonasson, J, Miazgowski, B, Miazgowski, T, Fekadu Worku Mijena, G, Mirmoeeni, S, Mirza-Aghazadeh-Attari, M, Mirzaei, H, Misra, S, Abdulmuhsin Mohammad, K, Mohammadi, E, Mohammadi, S, Momeneh Mohammadi, S, Mohammadian-Hafshejani, A, Mohammed, S, Abdulrahman Mohammed, T, Moka, N, H Mokdad, A, Mokhtari, Z, Molokhia, M, Momtazmanesh, S, Monasta, L, Moradi, G, Moradzadeh, R, Moraga, P, Morgado-da-Costa, J, Mubarik, S, Mulita, F, Naghavi, M, David Naimzada, M, Sung Nam, H, S Natto, Z, Prakash Nayak, B, Nazari, J, Nazemalhosseini-Mojarad, E, Negoi, I, Tat Nguyen, C, Hoang Nguyen, S, M Noor, N, Noori, M, Mohammad Ali Noori, S, Nu??ez-Samudio, V, Igwegbe Nzoputam, C, Oancea, B, Ololade Odukoya, O, Sikiru Oguntade, A, Okati-Aliabad, H, T Olagunju, A, O Olagunju, T, Ong, S, M Ostroff, S, Padron-Monedero, A, Pakzad, R, Pana, A, Pandey, A, Pashazadeh Kan, F, K Patel, U, Paudel, U, B Pereira, R, Perumalsamy, N, G Pestell, R, Zahid Piracha, Z, G Pollok, R, Pourshams, A, Pourtaheri, N, Prashant, A, Rabiee, M, Rabiee, N, Radfar, A, Rafiei, S, Rahman, M, Masoud Rahmani, A, Rahmanian, V, Rajai, N, Rajesh, A, Ramezani-Doroh, V, Ramezanzadeh, K, Ranabhat, K, Rashedi, S, Rashidi, A, Rashidi, M, Rastegar, M, Laith Rawaf, D, Rawaf, S, Rawassizadeh, R, Sadegh Razeghinia, M, N Renzaho, A, Rezaei, N, Rezaei, S, Rezaeian, M, Rezazadeh-Khadem, S, Roshandel, G, Mohamed Saber-Ayad, M, Saberzadeh-Ardestani, B, Saddik, B, Sadeghi, H, Saeed, U, Sahebazzamani, M, Sahebkar, A, Salek Farrokhi, A, Salimi, A, Salimzadeh, H, Samadi, P, Samaei, M, M Samy, A, Sanabria, J, M Santric-Milicevic, M, Arif Nadeem Saqib, M, Sarveazad, A, Sathian, B, Satpathy, M, Jayce Ceola Schneider, I, ekerija, M, G Sepanlou, S, Seylani, A, Sha, F, Mohammad Shafiee, S, Shaghaghi, Z, Shahabi, S, Shaker, E, Sharifian, M, Sharifi-Rad, J, Sheikhbahaei, S, K Shetty, J, Shirkoohi, R, Shobeiri, P, K Siddappa Malleshappa, S, Augusto Santos Silva, D, Silva Julian, G, Dinesh Singh, A, A Singh, J, Shahjahan Siraj, M, Reza Sivandzadeh, G, Yurievich Skryabin, V, Aleksandrovna Skryabina, A, Socea, B, Solmi, M, Sadegh Soltani-Zangbar, M, Song, S, Szerencs??s, V, Sz??cska, M, Tabar??s-Seisdedos, R, Tabibian, E, Taheri, M, Taheriabkenar, Y, Taherkhani, A, M Talaat, I, Tan, K, Tbakhi, A, Tesfaye, B, Tiyuri, A, Nigusse Tollosa, D, Touvier, M, Xuan Tran, B, Shalmeno Tusa, B, Ullah, I, Ullah, S, Vacante, M, Valadan Tahbaz, S, Veroux, M, Vo, B, Vos, T, Wang, C, Westerman, R, Woldemariam, M, Hossein Yahyazadeh Jabbari, S, Yang, L, Yazdanpanah, F, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Zahir, M, Zare, I, Zhang, Z, Zoladl, M, Sharma, R., Abbasi-Kangevari, M., Abd-Rabu, R., Abidi, H., Abu-Gharbieh, E., Acuna, J. M., Adhikari, S., Advani, S. M., Afzal, M. S., Aghaie Meybodi, M., Ahinkorah, B. O., Ahmad, S., Ahmadi, A., Ahmadi, S., Ahmed, H., Ahmed, L. A., Ahmed, M. B., Al Hamad, H., Alahdab, F., Alanezi, F. M., Alanzi, T. M., Alhalaiqa, F. A. N., Alimohamadi, Y., Alipour, V., Aljunid, S. M., Alkhayyat, M., Almustanyir, S., Al-Raddadi, R. M., Alvand, S., Alvis-Guzman, N., Amini, S., Ancuceanu, R., Anoushiravani, A., Anoushirvani, A. A., Ansari-Moghaddam, A., Arabloo, J., Aryannejad, A., Asghari Jafarabadi, M., Athari, S. S., Ausloos, F., Ausloos, M., Awedew, A. F., Awoke, M. A., Ayana, T. M., Azadnajafabad, S., Azami, H., Azangou-Khyavy, M., Azari Jafari, A., Badiye, A. D., Bagherieh, S., Bahadory, S., Baig, A. A., Baker, J. L., Banach, M., Barrow, A., Berhie, A. Y., Besharat, S., Bhagat, D. S., Bhagavathula, A. S., Bhala, N., Bhattacharyya, K., Bhojaraja, V. S., Bibi, S., Bijani, A., Biondi, A., Bjorge, T., Bodicha, B. B. A., Braithwaite, D., Brenner, H., Calina, D., Cao, C., Cao, Y., Carreras, G., Carvalho, F., Cerin, E., Chakinala, R. C., Cho, W. C. S., Chu, D. -T., Conde, J., Costa, V. M., Cruz-Martins, N., Dadras, O., Dai, X., Dandona, L., Dandona, R., Danielewicz, A., Demeke, F. M., Demissie, G. D., Desai, R., Dhamnetiya, D., Dianatinasab, M., Diaz, D., Didehdar, M., Doaei, S., Doan, L. P., Dodangeh, M., Eghbalian, F., Ejeta, D. D., Ekholuenetale, M., Ekundayo, T. C., El Sayed, I., Elhadi, M., Enyew, D. B., Eyayu, T., Ezzeddini, R., Fakhradiyev, I. R., Farooque, U., Farrokhpour, H., Farzadfar, F., Fatehizadeh, A., Fattahi, H., Fattahi, N., Fereidoonnezhad, M., Fernandes, E., Fetensa, G., Filip, I., Fischer, F., Foroutan, M., Gaal, P. A., Gad, M. M., Gallus, S., Garg, T., Getachew, T., Ghamari, S. -H., Ghashghaee, A., Ghith, N., Gholamalizadeh, M., Gholizadeh Navashenaq, J., Gizaw, A. T., Glasbey, J. C., Golechha, M., Goleij, P., Gonfa, K. B., Gorini, G., Guha, A., Gupta, S., Gupta, V. B., Gupta, V. K., Haddadi, R., Hafezi-Nejad, N., Haj-Mirzaian, A., Halwani, R., Haque, S., Hariri, S., Hasaballah, A. I., Hassanipour, S., Hay, S. I., Herteliu, C., Holla, R., Hosseini, M. -S., Hosseinzadeh, M., Hostiuc, M., Househ, M., Huang, J., Humayun, A., Iavicoli, I., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Islami, F., Iwagami, M., Jahani, M. A., Jakovljevic, M., Javaheri, T., Jayawardena, R., Jebai, R., Jha, R. P., Joo, T., Joseph, N., Joukar, F., Jozwiak, J. J., Kabir, A., Kalhor, R., Kamath, A., Kapoor, N., Karaye, I. M., Karimi, A., Kauppila, J. H., Kazemi, A., Keykhaei, M., Khader, Y. S., Khajuria, H., Khalilov, R., Khanali, J., Khayamzadeh, M., Khodadost, M., Kim, H., Kim, M. S., Kisa, A., Kisa, S., Kolahi, A. -A., Koohestani, H. R., Kopec, J. A., Koteeswaran, R., Koyanagi, A., Krishnamoorthy, Y., Kumar, G. A., Kumar, M., Kumar, V., La Vecchia, C., Lami, F. H., Landires, I., Ledda, C., Lee, S. -W., Lee, W. -C., Lee, Y. Y., Leong, E., Li, B., Lim, S. S., Lobo, S. W., Loureiro, J. A., Lunevicius, R., Madadizadeh, F., Mahmoodpoor, A., Majeed, A., Malekpour, M. -R., Malekzadeh, R., Malik, A. A., Mansour-Ghanaei, F., Mantovani, L. G., Martorell, M., Masoudi, S., Mathur, P., Meena, J. K., Mehrabi Nasab, E., Mendoza, W., Mentis, A. -F. A., Mestrovic, T., Miao Jonasson, J., Miazgowski, B., Miazgowski, T., Mijena, G. F. W., Mirmoeeni, S., Mirza-Aghazadeh-Attari, M., Mirzaei, H., Misra, S., Mohammad, K. A., Mohammadi, E., Mohammadi, S., Mohammadi, S. M., Mohammadian-Hafshejani, A., Mohammed, S., Mohammed, T. A., Moka, N., Mokdad, A. H., Mokhtari, Z., Molokhia, M., Momtazmanesh, S., Monasta, L., Moradi, G., Moradzadeh, R., Moraga, P., Morgado-da-Costa, J., Mubarik, S., Mulita, F., Naghavi, M., Naimzada, M. D., Nam, H. S., Natto, Z. S., Nayak, B. P., Nazari, J., Nazemalhosseini-Mojarad, E., Negoi, I., Nguyen, C. T., Nguyen, S. H., Noor, N. M., Noori, M., Noori, S. M. A., Nunez-Samudio, V., Nzoputam, C. I., Oancea, B., Odukoya, O. O., Oguntade, A. S., Okati-Aliabad, H., Olagunju, A. T., Olagunju, T. O., Ong, S., Ostroff, S. M., Padron-Monedero, A., Pakzad, R., Pana, A., Pandey, A., Pashazadeh Kan, F., Patel, U. K., Paudel, U., Pereira, R. B., Perumalsamy, N., Pestell, R. G., Piracha, Z. Z., Pollok, R. C. G., Pourshams, A., Pourtaheri, N., Prashant, A., Rabiee, M., Rabiee, N., Radfar, A., Rafiei, S., Rahman, M., Rahmani, A. M., Rahmanian, V., Rajai, N., Rajesh, A., Ramezani-Doroh, V., Ramezanzadeh, K., Ranabhat, K., Rashedi, S., Rashidi, A., Rashidi, M., Rashidi, M. -M., Rastegar, M., Rawaf, D. L., Rawaf, S., Rawassizadeh, R., Razeghinia, M. S., Renzaho, A. M. N., Rezaei, N., Rezaei, S., Rezaeian, M., Rezazadeh-Khadem, S., Roshandel, G., Saber-Ayad, M. M., Saberzadeh-Ardestani, B., Saddik, B., Sadeghi, H., Saeed, U., Sahebazzamani, M., Sahebkar, A., Salek Farrokhi, A., Salimi, A., Salimzadeh, H., Samadi, P., Samaei, M., Samy, A. M., Sanabria, J., Santric-Milicevic, M. M., Saqib, M. A. N., Sarveazad, A., Sathian, B., Satpathy, M., Schneider, I. J. C., Sekerija, M., Sepanlou, S. G., Seylani, A., Sha, F., Shafiee, S. M., Shaghaghi, Z., Shahabi, S., Shaker, E., Sharifian, M., Sharifi-Rad, J., Sheikhbahaei, S., Shetty, J. K., Shirkoohi, R., Shobeiri, P., Siddappa Malleshappa, S. K., Silva, D. A. S., Silva Julian, G., Singh, A. D., Singh, J. A., Siraj, M. S., Sivandzadeh, G. R., Skryabin, V. Y., Skryabina, A. A., Socea, B., Solmi, M., Soltani-Zangbar, M. S., Song, S., Szerencses, V., Szocska, M., Tabares-Seisdedos, R., Tabibian, E., Taheri, M., Taheriabkenar, Y., Taherkhani, A., Talaat, I. M., Tan, K. -K., Tbakhi, A., Tesfaye, B., Tiyuri, A., Tollosa, D. N., Touvier, M., Tran, B. X., Tusa, B. S., Ullah, I., Ullah, S., Vacante, M., Valadan Tahbaz, S., Veroux, M., Vo, B., Vos, T., Wang, C., Westerman, R., Woldemariam, M., Yahyazadeh Jabbari, S. H., Yang, L., Yazdanpanah, F., Yu, C., Yuce, D., Yunusa, I., Zadnik, V., Zahir, M., Zare, I., Zhang, Z. -J., Zoladl, M., Epidemiologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, and Bill & Melinda Gates Foundation
Subjects: Adult, MED/42 - IGIENE GENERALE E APPLICATA, IMPACT, colorectal cancer, Colorectal Neoplasm, GBD 2019 Colorectal Cancer Collaborators, HEREDITARY, Global Burden of Disease, Cancer screening, DISPARITIES, SDG 3 - Good Health and Well-being, Cancer treatment strategies, Risk Factors, Quality-Adjusted Life Year, COLON, Global studies, DALY, GBD, colorectal cancer, risk factors, Humans, Global Burden of Disease Study, Early Detection of Cancer, Hepatology, MORTALITY, Gastroenterology, Cancer incidence rates, Middle Aged, Cancer burden, SURVIVAL, SEX, GENDER, Quality-Adjusted Life Years, Colorectal Neoplasms, Human
Abstract: Correction to Lancet Gastroenterol Hepatol 2022; 7: 627-47. Lancet Gastroenterol Hepatol. 2022 Aug;7(8):704. doi: 10.1016/S2468-1253(22)00210-2. PMID: 35809605. Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990-2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408-868 574) to 2·17 million (2·00-2·34), and deaths increased from 518 126 (493 682-537 877) to 1·09 million (1·02-1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3-23·0) per 100 000 to 26·7 (24·6-28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5-14·9) per 100 000 to 13·7 (12·6-14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7-320·7) per 100 000 to 295·5 (275·2-313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9-80·0] per 100 000), Monaco (60·7 [48·5-73·6] per 100 000), and Andorra (56·6 [42·8-71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0-37·1] per 100 000), Brunei (30·3 [26·6-34·1] per 100 000), and Hungary (28·6 [23·6-34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence rates was observed in younger adults (age
Published: 2022

54. Funções cognitivas de mulheres diagnosticadas com câncer de mama em tratamento quimioterápico adjuvante

Author: Tainara de Lima Mello, Juliedy Kupske, Janice de Fátima Pavan Zanella, Ione Jayce Ceola Schneider, and Rodrigo de Rosso Krug
Abstract: Objetivo: O objetivo deste estudo é revisar subsídios sobre o perfil neuropsicológico de mulheres com câncer de mama em tratamento quimioterápico. Metodologia: Tratou-se de uma revisão de escopo a partir do levantamento dos últimos cinco anos nas bases de dados PubMed, Scielo e Lilacs. Foram seguidos os parâmetros propostos pelo PRISMA e utilizados os seguintes descritores: “câncer de mama/ breast neoplasms” e “avaliação neuropsicológica/ neuropsychological evaluation”. Resultados: Foram encontrados 8 artigos. Os autorrelatos de comprometimento cognitivo ainda são maiores em comparação com resultados obtidos através de instrumentos neuropsicológicos, no entanto, os déficits cognitivos apresentados com maior intensidade se referem a funções executivas, memória, atenção e velocidade de processamento. Conclusões: Não existe consenso quanto ao impacto do tratamento oncológico (quimioterapia) na cognição, devendo haver padronização dos instrumentos para avaliação, bem como, implementação de novas tecnologias de neuroimagem.
Published: 2021

55. Rehabilitation in Survivors of COVID-19 (RE2SCUE): a non-randomized, controlled and open study

Author: Maria Cristine Campos, Tatyana Nery, Ana Elisa Speck, Maiqueli Arpini, Moisés Moraes Antunes, Ana Cristina de Bem Alves, Naiara de Souza Santos, Maria Paula Pereira Matos, Nelson Schmidt Junior, Letícia Roehe Bicca, Camila Mascarelo Panisson, Mariana Alves Freitas, Fernando Diefenthaeler, Heloyse Uliam Kuriki, Vanessa Damin, Rodrigo Oliveira Da Rosa, Josiane Bueno Gress, Ione Jayce Ceola Schneider, Danielle Soares Rocha Vieira, Livia Arcêncio, and Aderbal Silva Aguiar
Abstract: The sequelae of coronavirus disease-2019 (COVID-19) are another socio-economic problem of the pandemic. Fatigue and dyspnea are the most prevalent symptoms. It is not known whether exercise can be used to treat long COVID-19. This study aimed to investigate the effects of an 8-week face-to-face rehabilitation program on COVID-19 compared to a remote monitoring group. A total of 37 participants (24.3% hospitalized) were assessed before and after rehabilitation (n = 22; 40.8 ± 10.0 years) or remote monitoring (n = 15; 45.4 ± 10.5 years). The participants were allocated according to their preferences. Both groups showed improved fatigue and exercise capacity (Incremental Shuttle Walk Test). Participants in the face-to-face rehabilitation group showed improved dyspnea (Pulmonary Functional Status and Dyspnea Questionnaire), anxiety (Hospital Anxiety and Depression Scale), attention, and short-term memory (d2-R and Rey's Auditory-Verbal Learning Test). Of the main sequelae, fatigue improves naturally, whereas dyspnea requires rehabilitation. Our results demonstrated the benefits of exercise for COVID-19 sequelae.
Published: 2022

56. Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Chi Linh Hoang, Christopher J L Murray, Faheem Hyder Pottoo, Feng Sha, Simon I. Hay, Jianrong Zhang, Nikita Otstavnov, Eman Abu-Gharbieh, Azeem Majeed, Lorenzo Monasta, Jasvinder A. Singh, Zhi-Jiang Zhang, Jalal Arabloo, Jonathan M. Kocarnik, Sadaf G. Sepanlou, Rahmatollah Moradzadeh, Freddy Sitas, Sanjeev Misra, Lisa M. Force, Irina Filip, Rafael Tabarés-Seisdedos, Shahabeddin Rezaei, Amir Radfar, Luca Ronfani, Iván Landires, Rovshan Khalilov, Brijesh Sathian, Bingyu Li, Farhad Pishgar, Mario Šekerija, Priya Rathi, Catalina Liliana Andrei, Michael T. Chung, Ali Bijani, Ritesh G. Menezes, Odgerel Chimed-Ochir, Ken Takahashi, Nobuyuki Horita, Supreet Kaur, Rakhi Dandona, Alan D. Lopez, Alireza Rafiei, Joana Morgado-da-Costa, Kelly Compton, Akram Pourshams, G Anil Kumar, Dinh-Toi Chu, Deniz Yuce, Huong Lan Thi Nguyen, Virginia Núñez-Samudio, Ahmad Ghashghaee, Cuong Tat Nguyen, Kazem Zendehdel, Maria Teresa Bustamante-Teixeira, Aaron Cohen, Mohsen Naghavi, Mukhammad David Naimzada, Lalit Dandona, Pradhum Ram, Ione Jayce Ceola Schneider, Thomas Roberts, Michael Brauer, Meseret Derbew Molla, Vesna Zadnik, Syed Mohamed Aljunid, Morteza Arab-Zozani, Lidia Morawska, Abebaw Alemayehu Desta, Qing Lan, Rajesh Sharma, Mahesh P A, David Laith Rawaf, Ali H. Mokdad, Tomasz Miazgowski, Zabihollah Yousefi, Seyed Sina Naghibi Irvani, Reza Malekzadeh, Paul J. Villeneuve, Masood Ali Shaikh, Muhammad Aziz Rahman, Sohail Ahmad, Abdollah Mohammadian-Hafshejani, Gholamreza Roshandel, Atalel Fentahun Awedew, Hassan Abolhassani, Hermann Brenner, Sara Sheikhbahaei, Elvynna Leong, Mohammad Rabiee, Abdallah M. Samy, Eyayou Girma Tadesse, Milena Santric-Milicevic, Silvano Gallus, Carlos A Castañeda-Orjuela, Mowafa Househ, Xiaochen Dai, Marco Vacante, Mihaela Hostiuc, Adrian Pana, Salman Rawaf, Sahar Saeedi Moghaddam, Francesco Saverio Violante, Weijia Fu, Paschalis Steiropoulos, Vahid Alipour, Tone Bjørge, Savita Lasrado, Burcu Kucuk Bicer, Farshad Farzadfar, Shafiu Mohammed, Fares Alahdab, Paolo Lauriola, Saeed Amini, Eugenio Traini, Maryam Zamanian, Samer Hamidi, Rajan Nikbakhsh, Pawan Faris, Birhan Gebresillassie Gebregiorgis, Emerito Jose A. Faraon, Stanislav S. Otstavnov, Shane D. Morrison, Marcel Ausloos, Aziz Sheikh, Eun-Kee Park, Antonio Biondi, Zahra Aryan, Claudiu Herteliu, Ivo Iavicoli, Hedyeh Ebrahimi, Nicholas L S Roberts, Navid Rabiee, Tudorel Andrei, Catherine Bisignano, Giulia Carreras, Andrew T Olagunju, Ejaz Ahmad Khan, Dejana Braithwaite, Alex Molassiotis, Kebebe Bekele Gonfa, Bárbara Niegia Garcia de Goulart, Javad Nazari, Giuseppe Gorini, Mahaveer Golechha, Bach Xuan Tran, Ravensara S. Travillian, Zahid A Butt, Baye Dagnew, Atif Amin Baig, Nima Rezaei, Nima Hafezi-Nejad, Khanh Bao Tran, Malke Asaad, Tim Driscoll, Navid Manafi, Frances E. Dean, Shailesh Advani, Stephen S Lim, Robert Ancuceanu, Milena Ilic, Maximiliano Ribeiro Guerra, Ashwin Kamath, Carlo La Vecchia, Farhad Islami, Sudeep K Siddappa Malleshappa, Irena Ilic, Emma Elizabeth Spurlock, Florian Fischer, GBD 2019 Respiratory Tract Cancer Collaborator, and Francesco S. Violante
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, CELL LUNG-CANCER, EGFR, Respiratory System, GBD 2019 Respiratory Tract Cancers Collaborators, Global Burden of Disease, 1117 Public Health and Health Services, Critical Care Medicine, Risk Factors, Neoplasms, General & Internal Medicine, Internal medicine, Tobacco Smoking, Humans, Medicine, Risk factor, Lung cancer, Bronchus, Science & Technology, SARS-CoV-2, MUTATIONS, business.industry, Risk Factor, MORTALITY, Incidence, Mortality rate, Incidence (epidemiology), cancer, GBD, respiratory tract, Smoking, COVID-19, Cancer, 1103 Clinical Sciences, Articles, AIR-POLLUTION, respiratory system, medicine.disease, Respiratory Tract Neoplasms, Respiratory Tract Neoplasm, medicine.anatomical_structure, Years of potential life lost, Socioeconomic Factors, Relative risk, CIGARETTE-SMOKING, business, Life Sciences & Biomedicine, Human, SMOKERS, 1199 Other Medical and Health Sciences
Abstract: Summary Background Prevention, control, and treatment of respiratory tract cancers are important steps towards achieving target 3.4 of the UN Sustainable Development Goals (SDGs)—a one-third reduction in premature mortality due to non-communicable diseases by 2030. We aimed to provide global, regional, and national estimates of the burden of tracheal, bronchus, and lung cancer and larynx cancer and their attributable risks from 1990 to 2019. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 methodology, we evaluated the incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs) of respiratory tract cancers (ie, tracheal, bronchus, and lung cancer and larynx cancer). Deaths from tracheal, bronchus, and lung cancer and larynx cancer attributable to each risk factor were estimated on the basis of risk exposure, relative risks, and the theoretical minimum risk exposure level input from 204 countries and territories, stratified by sex and Socio-demographic Index (SDI). Trends were estimated from 1990 to 2019, with an emphasis on the 2010–19 period. Findings Globally, there were 2·26 million (95% uncertainty interval 2·07 to 2·45) new cases of tracheal, bronchus, and lung cancer, and 2·04 million (1·88 to 2·19) deaths and 45·9 million (42·3 to 49·3) DALYs due to tracheal, bronchus, and lung cancer in 2019. There were 209 000 (194 000 to 225 000) new cases of larynx cancer, and 123 000 (115 000 to 133 000) deaths and 3·26 million (3·03 to 3·51) DALYs due to larynx cancer globally in 2019. From 2010 to 2019, the number of new tracheal, bronchus, and lung cancer cases increased by 23·3% (12·9 to 33·6) globally and the number of larynx cancer cases increased by 24·7% (16·0 to 34·1) globally. Global age-standardised incidence rates of tracheal, bronchus, and lung cancer decreased by 7·4% (−16·8 to 1·6) and age-standardised incidence rates of larynx cancer decreased by 3·0% (−10·5 to 5·0) in males over the past decade; however, during the same period, age-standardised incidence rates in females increased by 0·9% (−8·2 to 10·2) for tracheal, bronchus, and lung cancer and decreased by 0·5% (−8·4 to 8·1) for larynx cancer. Furthermore, although age-standardised incidence and death rates declined in both sexes combined from 2010 to 2019 at the global level for tracheal, bronchus, lung and larynx cancers, some locations had rising rates, particularly those on the lower end of the SDI range. Smoking contributed to an estimated 64·2% (61·9–66·4) of all deaths from tracheal, bronchus, and lung cancer and 63·4% (56·3–69·3) of all deaths from larynx cancer in 2019. For males and for both sexes combined, smoking was the leading specific risk factor for age-standardised deaths from tracheal, bronchus, and lung cancer per 100 000 in all SDI quintiles and GBD regions in 2019. However, among females, household air pollution from solid fuels was the leading specific risk factor in the low SDI quintile and in three GBD regions (central, eastern, and western sub-Saharan Africa) in 2019. Interpretation The numbers of incident cases and deaths from tracheal, bronchus, and lung cancer and larynx cancer increased globally during the past decade. Even more concerning, age-standardised incidence and death rates due to tracheal, bronchus, lung cancer and larynx cancer increased in some populations—namely, in the lower SDI quintiles and among females. Preventive measures such as smoking control interventions, air quality management programmes focused on major air pollution sources, and widespread access to clean energy should be prioritised in these settings. Funding Bill & Melinda Gates Foundation.
Published: 2021

57. Mortalidade em idosos como desfecho da associação de sintomas depressivos e deficiência de 25(OH)D: uma revisão integrativa

Author: Bruna Daniel Rabelo and Ione Jayce Ceola Schneider
Subjects: General Earth and Planetary Sciences, General Environmental Science
Abstract: A depressão é uma doença que causa grande incapacidade e possui alta prevalência entre idosos. Também de expressiva distribuição se encontra a deficiência de vitamina D, que favorece o desenvolvimento de sintomas depressivos. Tanto a depressão quanto baixos níveis de vitamina D isoladamente são preditores de maior mortalidade. Esta revisão integrativa teve o objetivo de levantar informações acerca da combinação de deficiência de vitamina D e presença de depressão, e a influência na mortalidade em idosos. Foi realizada pesquisa nas bases de dados eletrônicas BVS, Embase, Cochrane e PubMed, sem restrição do tipo de estudo, linguística ou de tempo, com os descritores “depressão”, “deficiência de vitamina D”, “idosos”, “mortalidade”, e suas variações. A busca inicial identificou 302 artigos. Após exclusão dos duplicados e dos trabalhos que não englobaram todos os descritores de interesse, foram incluídos dois artigos para a presente revisão integrativa. Identificou-se que a população estudada tinha baixos níveis de 25(OH)D, e que isto se associou à ocorrência de sintomas depressivos. A análise conjunta de depressão e deficiência de 25(OH)D, e o impacto na mortalidade foi realizada em apenas um dos artigos. Neste, os indivíduos deprimidos com maior risco de óbito apresentavam deficiência de 25(OH)D. Em conclusão, observou-se associação entre depressão e baixos níveis de vitamina D, relacionando-se à maior mortalidade. Estas variáveis são modificáveis, porém, a literatura apresenta poucos dados neste contexto para permitir uma tomada de decisão. Mais pesquisas na área poderão esclarecer a relação que existe entre depressão, deficiência de vitamina D e mortalidade, e possibilitar modificação no curso deste desfecho.
Published: 2023

58. O efeito da utilização de computadores e Internet na função cognitiva de idosos

Author: Eleonora d'Orsi, Ione Jayce Ceola Schneider, Luiz Roberto Ramos, Anna Quialheiro Abreu da Silva, André Junqueira Xavier, and Rodrigo de Rosso Krug
Subjects: medicine.medical_specialty, business.industry, Statistical significance, Physical therapy, Medicine, Cognition, The Internet, Odds ratio, business, Cognitive impairment, Logistic regression, Confidence interval, Odds
Abstract: Objetivo: Estimar o efeito da participação em grupos de estimulação e reabilitação cognitiva mediados pelo uso de computadores e Internet sobre a função cognitiva de idosos. Métodos: Estudo prospectivo de intervenção controlada e randomizado por sorteio realizado de 2010 a 2011 com pacientes voluntários atendidos em uma Clínica de Memória do Sul de Santa Catarina, Brasil. O grupo de intervenção (n=56) recebeu um programa de estimulação cognitiva de 20 sessões quinzenais de 1,5 horas cada. O grupo controle (n=53) recebeu acompanhamento médico de rotina. Ambos os grupos receberam orientações de saúde, atividade física e não faziam uso prévio de computadores e Internet. O desfecho foi o ganho de 4 pontos ou mais no Mini Exame de Estado Mental, entre as avaliações. Foi realizada análise de regressão logística com resultados expressos em Odds Ratio (OR) e seus respectivos intervalos de confiança de 95% (IC95%), com nível de significância de p≤0,05. Resultados: O grupo de intervenção obteve uma probabilidade 4,63 vezes maior do desfecho (OR= 4,63; IC 95%: 1,43-14,94) em relação ao grupo controle. Conclui-se que a participação em grupos de estimulação cognitiva mediado pelo uso de computadores e Internet está associado a melhora significativa na função cognitiva de idosos com comprometimento cognitivo leve.
Published: 2021

59. Internet of Things as support to reduce hospital errors related to medication administration

Author: Luis Fernando Espinosa Cocian, Analúcia Schiaffino Morales, and Ione Jayce Ceola Schneider
Subjects: General Earth and Planetary Sciences, General Environmental Science
Abstract: Objective: The high potential of digital technologies to reduce medication errors in patients hospitalized or under hospital care was explored in this investigation. The study identifies common types of medication errors and their probable causes. Furthermore, examines the technological innovation solutions available that have not yet been applied in this context, specifically the Internet of Things usage to reduce medication errors through a practical example. Methods: A rapid review was applied, exploring the papers from two databases. The analysis was limited to the period from 2017 to 2021, resulting in 147 articles from the VHL Regional Portal – Virtual Health Library and 257 articles from the PubMed database. Results: There were analyzed 40 studies. An error mapping related to the theme was made. Also, the technology application and their effectiveness were identified in the studies. According to the research, inattention or distraction due to the excessive journey of work was pointed out as the main reason that leads to medication errors with the systems employed. Conclusion: There are several opportunities to improve hospital procedures with new technological approaches. By implementing innovative technologies, hospital medication errors can be managed more efficiently and reduce costs and waste with errors medication.
Published: 2023

60. Trends in mortality due to traffic accidents in Brazil during the period from 1997 to 2015 for the male population

Author: Ameg Dalpiaz, Ione Jayce Ceola Schneider, Amanda Pereira, Ramon Bauer Cardoso, Alexandre Márcio Marcolino, and Rafael Inácio Barbosa
Subjects: mortalidade, external causes, causas externas, acidentes de transporte, accidents, acidentes, General Medicine, mortality, traffic accidents
Abstract: Background Traffic accidents are one of the main causes of death in Brazil and the increase in the mortality rate is concerning. Objective The study aims to perform a temporal analysis of mortality trends related to traffic accidents in Brazil and its states. Method This is an ecological study of time series of mortality from traffic accidents in Brazil and its Federative Units. Data was obtained from the Information System for Mortality (SIM), processed by Datasus and classified under the headings V01 to V89 (CID-10). Specific mortality rates were calculated and adjusted by age. The temporal tendency analysis was run on the Joinpoint Regression Program. Results The Brazilian male population showed no change in the average annual percentage for the mortality rate (-0.8%; CI 95% -1.7;0.1). Ten states showed increased mortality rates; nine presented a decline, and eight remained constant throughout the period. Conclusion The male population showed no change in the rates, but the mortality rate for the general Brazilian population decreased by 1% per year from 1997 to 2015. Both general and male populations had a decrease of 4.6% and 4.9% per year during the last years, respectively (2012-2015). Resumo Introdução Acidentes de trânsito são uma das principais causas de morte no Brasil e no mundo. Objetivo O estudo teve por objetivo realizar uma análise temporal da tendência de mortalidade por acidentes de transportes terrestres no Brasil. Método Estudo ecológico de séries temporais da mortalidade por acidentes de transporte terrestre no Brasil no período de 1997 a 2015 para a população masculina. Os dados são provenientes do Sistema de Informação sobre Mortalidade (SIM), processados pelo Datasus e classificados nas rubricas V01 a V89 (CID-10). Foram calculadas as taxas específicas de mortalidade, ajustadas por idade, e realizada análise da tendência temporal através do software Joinpoint Regression Program. Resultados A população brasileira masculina não apresentou mudanças na taxa de mortalidade ao longo dos anos (-0.8%; CI 95% - 1.7;0.1). Dez estados tiveram aumento nas taxas de mortalidade, nove reduziram e oito mantiveram as taxas. Conclusão A população masculina não apresentou diferença nas taxas, entretanto, a população geral apresentou redução de 1% ao ano na taxa mortalidade. Além disso, ambas populações geral e masculina mostraram uma redução de 4,6% e 4,9% ao ano durante os últimos anos (2012- 2015).
Published: 2022

61. The combined effect of anemia and dynapenia on mortality risk in older adults: 10-Year evidence from the ELSA cohort study

Author: Mariane Marques Luiz, Ione Jayce Ceola Schneider, Heloyse Uliam Kuriki, André Fattori, Vanessa Pereira Corrêa, Andrew Steptoe, Tiago da Silva Alexandre, and Cesar de Oliveira
Subjects: Male, Aging, Health (social science), Hand Strength, Anemia, Cohort Studies, Risk Factors, Humans, Female, Longitudinal Studies, Geriatrics and Gerontology, Gerontology, Aged, Follow-Up Studies
Abstract: Anemia and dynapenia can occur simultaneously. Separately, both conditions increase the mortality risk with advancing age. However, there is no epidemiological evidence on the combined effect of these conditions on mortality in older adults. We investigated whether combined anemia and dynapenia increase the mortality risk, and whether there are gender differences.A 10-year follow-up study was conducted involving 5,310 older adults from the English Longitudinal Study of Ageing (ELSA). According to the diagnosis of anemia (hemoglobin concentration13.0 g/dL in men and12.0 g/dL in women) and dynapenia (grip strength26 kg for men and16 kg for women), individuals at baseline were categorized as "non-anemic/non-dynapenic", "dynapenic", "anemic" and "anemic/dynapenic". The outcome was all-cause mortality during the follow-up period.A total of 984 deaths were computed during the follow-up (63.7% in non-anemic/non-dynapenic, 22.8% in dynapenic, 7.5% in anemic and 6.0% in anemic/dynapenic). Adjusted Cox proportional hazard models stratified by sex showed that anemia and dynapenia combined was associated with an increased mortality risk in men (HR: 1.64; 95% IC 1.08 - 2.50) and women (HR: 2.17; 95% CI 1.44 - 3.26). Anemia in men (HR: 1.68; 95% CI 1.22 - 2.32) and dynapenia in women (HR: 1.37; 95% CI 1.09 - 1.72) were also risk factors for mortality.The coexistence of anemia and dynapenia increases the mortality risk, highlighting the need for early identification, prevention, and treatment of these conditions to reduce their complications and the mortality risk.
Published: 2022

62. The global burden of cancer attributable to risk factors, 2010–19 : A systematic analysis for the Global Burden of Disease Study 2019

Author: Khanh Bao Tran, Justin J Lang, Kelly Compton, Rixing Xu, Alistair R Acheson, Hannah Jacqueline Henrikson, Jonathan M Kocarnik, Louise Penberthy, Amirali Aali, Qamar Abbas, Behzad Abbasi, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Michael Abdelmasseh, Sherief Abd-Elsalam, Ahmed Abdelwahab Abdelwahab, Gholamreza Abdoli, Hanan Abdulkadir Abdulkadir, Aidin Abedi, Kedir Hussein Abegaz, Hassan Abidi, Richard Gyan Aboagye, Hassan Abolhassani, Abdorrahim Absalan, Yonas Derso Abtew, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Basavaprabhu Achappa, Juan Manuel Acuna, Daniel Addison, Isaac Yeboah Addo, Oyelola A Adegboye, Miracle Ayomikun Adesina, Mohammad Adnan, Qorinah Estiningtyas Sakilah Adnani, Shailesh M Advani, Sumia Afrin, Muhammad Sohail Afzal, Manik Aggarwal, Bright Opoku Ahinkorah, Araz Ramazan Ahmad, Rizwan Ahmad, Sajjad Ahmad, Sohail Ahmad, Sepideh Ahmadi, Haroon Ahmed, Luai A Ahmed, Muktar Beshir Ahmed, Tarik Ahmed Rashid, Wajeeha Aiman, Marjan Ajami, Gizachew Taddesse Akalu, Mostafa Akbarzadeh-Khiavi, Addis Aklilu, Maxwell Akonde, Chisom Joyqueenet Akunna, Hanadi Al Hamad, Fares Alahdab, Fahad Mashhour Alanezi, Turki M Alanzi, Saleh Ali Alessy, Abdelazeem M Algammal, Mohammed Khaled Al-Hanawi, Robert Kaba Alhassan, Beriwan Abdulqadir Ali, Liaqat Ali, Syed Shujait Ali, Yousef Alimohamadi, Vahid Alipour, Syed Mohamed Aljunid, Motasem Alkhayyat, Sadeq Ali Ali Al-Maweri, Sami Almustanyir, Nivaldo Alonso, Shehabaldin Alqalyoobi, Rajaa M Al-Raddadi, Rami H Hani Al-Rifai, Salman Khalifah Al-Sabah, Ala'a B Al-Tammemi, Haya Altawalah, Nelson Alvis-Guzman, Firehiwot Amare, Edward Kwabena Ameyaw, Javad Javad Aminian Dehkordi, Mohammad Hosein Amirzade-Iranaq, Hubert Amu, Ganiyu Adeniyi Amusa, Robert Ancuceanu, Jason A Anderson, Yaregal Animut Animut, Amir Anoushiravani, Ali Arash Anoushirvani, Alireza Ansari-Moghaddam, Mustafa Geleto Ansha, Benny Antony, Maxwell Hubert Antwi, Sumadi Lukman Anwar, Razique Anwer, Anayochukwu Edward Anyasodor, Jalal Arabloo, Morteza Arab-Zozani, Olatunde Aremu, Ayele Mamo Argaw, Hany Ariffin, Timur Aripov, Muhammad Arshad, Al Artaman, Judie Arulappan, Raphael Taiwo Aruleba, Armin Aryannejad, Malke Asaad, Mulusew A Asemahagn, Zatollah Asemi, Mohammad Asghari-Jafarabadi, Tahira Ashraf, Reza Assadi, Mohammad Athar, Seyyed Shamsadin Athari, Maha Moh'd Wahbi Atout, Sameh Attia, Avinash Aujayeb, Marcel Ausloos, Leticia Avila-Burgos, Atalel Fentahun Awedew, Mamaru Ayenew Awoke, Tewachew Awoke, Beatriz Paulina Ayala Quintanilla, Tegegn Mulatu Ayana, Solomon Shitu Ayen, Davood Azadi, Sina Azadnajafabad, Saber Azami-Aghdash, Melkalem Mamuye Azanaw, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Hosein Azizi, Ahmed Y Y Azzam, Amirhesam Babajani, Muhammad Badar, Ashish D Badiye, Nayereh Baghcheghi, Nader Bagheri, Sara Bagherieh, Saeed Bahadory, Atif Amin Baig, Jennifer L Baker, Ahad Bakhtiari, Ravleen Kaur Bakshi, Maciej Banach, Indrajit Banerjee, Mainak Bardhan, Francesco Barone-Adesi, Fabio Barra, Amadou Barrow, Nasir Z Bashir, Azadeh Bashiri, Saurav Basu, Abdul-Monim Mohammad Batiha, Aeysha Begum, Alehegn Bekele Bekele, Alemayehu Sayih Belay, Melaku Ashagrie Belete, Uzma Iqbal Belgaumi, Arielle Wilder Bell, Luis Belo, Habib Benzian, Alemshet Yirga Berhie, Amiel Nazer C Bermudez, Eduardo Bernabe, Akshaya Srikanth Bhagavathula, Neeraj Bhala, Bharti Bhandari Bhandari, Nikha Bhardwaj, Pankaj Bhardwaj, Krittika Bhattacharyya, Vijayalakshmi S Bhojaraja, Soumitra S Bhuyan, Sadia Bibi, Awraris Hailu Bilchut, Bagas Suryo Bintoro, Antonio Biondi, Mesfin Geremaw Birega Birega, Habitu Eshetu Birhan, Tone Bjørge, Oleg Blyuss, Belay Boda Abule Bodicha, Srinivasa Rao Bolla, Archith Boloor, Cristina Bosetti, Dejana Braithwaite, Michael Brauer, Hermann Brenner, Andrey Nikolaevich Briko, Nikolay Ivanovich Briko, Christina Maree Buchanan, Norma B Bulamu, Maria Teresa Bustamante-Teixeira, Muhammad Hammad Butt, Nadeem Shafique Butt, Zahid A Butt, Florentino Luciano Caetano dos Santos, Luis Alberto Cámera, Chao Cao, Yin Cao, Giulia Carreras, Márcia Carvalho, Francieli Cembranel, Ester Cerin, Promit Ananyo Chakraborty, Periklis Charalampous, Vijay Kumar Chattu, Odgerel Chimed-Ochir, Jesus Lorenzo Chirinos-Caceres, Daniel Youngwhan Cho, William C S Cho, Devasahayam J Christopher, Dinh-Toi Chu, Isaac Sunday Chukwu, Aaron J Cohen, Joao Conde, Sandra Cortés, Vera Marisa Costa, Natália Cruz-Martins, Garland T Culbreth, Omid Dadras, Fentaw Teshome Dagnaw, Saad M A Dahlawi, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, Anna Danielewicz, An Thi Minh Dao, Reza Darvishi Cheshmeh Soltani, Aso Mohammad Darwesh, Saswati Das, Dragos Virgil Davitoiu, Elham Davtalab Esmaeili, Fernando Pio De la Hoz, Sisay Abebe Debela, Azizallah Dehghan, Biniyam Demisse, Fitsum Wolde Demisse, Edgar Denova-Gutiérrez, Afshin Derakhshani, Meseret Derbew Molla, Diriba Dereje, Kalkidan Solomon Deribe, Rupak Desai, Markos Desalegn Desalegn, Fikadu Nugusu Dessalegn, Samuel Abebe A Dessalegni, Gashaw Dessie, Abebaw Alemayehu Desta, Syed Masudur Rahman Dewan, Samath Dhamminda Dharmaratne, Meghnath Dhimal, Mostafa Dianatinasab, Nancy Diao, Daniel Diaz, Lankamo Ena Digesa, Shilpi Gupta Dixit, Saeid Doaei, Linh Phuong Doan, Paul Narh Doku, Deepa Dongarwar, Wendel Mombaque dos Santos, Tim Robert Driscoll, Haneil Larson Dsouza, Oyewole Christopher Durojaiye, Sareh Edalati, Fatemeh Eghbalian, Elham Ehsani-Chimeh, Ebrahim Eini, Michael Ekholuenetale, Temitope Cyrus Ekundayo, Donatus U Ekwueme, Maha El Tantawi, Mostafa Ahmed Elbahnasawy, Iffat Elbarazi, Hesham Elghazaly, Muhammed Elhadi, Waseem El-Huneidi, Mohammad Hassan Emamian, Luchuo Engelbert Bain, Daniel Berhanie Enyew, Ryenchindorj Erkhembayar, Tegegne Eshetu, Babak Eshrati, Sharareh Eskandarieh, Juan Espinosa-Montero, Farshid Etaee, Azin Etemadimanesh, Tahir Eyayu, Ifeanyi Jude Ezeonwumelu, Sayeh Ezzikouri, Adeniyi Francis Fagbamigbe, Saman Fahimi, Ildar Ravisovich Fakhradiyev, Emerito Jose A Faraon, Jawad Fares, Abbas Farmany, Umar Farooque, Hossein Farrokhpour, Abidemi Omolara Fasanmi, Ali Fatehizadeh, Wafa Fatima, Hamed Fattahi, Ginenus Fekadu, Berhanu Elfu Feleke, Allegra Allegra Ferrari, Simone Ferrero, Lorenzo Ferro Desideri, Irina Filip, Florian Fischer, Roham Foroumadi, Masoud Foroutan, Takeshi Fukumoto, Peter Andras Gaal, Mohamed M Gad, Muktar A Gadanya, Abduzhappar Gaipov, Nasrin Galehdar, Silvano Gallus, Tushar Garg, Mariana Gaspar Fonseca, Yosef Haile Gebremariam, Teferi Gebru Gebremeskel, Mathewos Alemu Gebremichael, Yohannes Fikadu Geda, Yibeltal Yismaw Gela, Belete Negese Belete Gemeda, Melaku Getachew, Motuma Erena Getachew, Kazem Ghaffari, Mansour Ghafourifard, Seyyed-Hadi Ghamari, Mohammad Ghasemi Nour, Fariba Ghassemi, Ajnish Ghimire, Nermin Ghith, Maryam Gholamalizadeh, Jamshid Gholizadeh Navashenaq, Sherief Ghozy, Syed Amir Gilani, Paramjit Singh Gill, Themba G Ginindza, Abraham Tamirat T Gizaw, James C Glasbey, Justyna Godos, Amit Goel, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Mohamad Golitaleb, Giuseppe Gorini, Bárbara Niegia Garcia Goulart, Giuseppe Grosso, Habtamu Alganeh Guadie, Mohammed Ibrahim Mohialdeen Gubari, Temesgen Worku Gudayu, Maximiliano Ribeiro Guerra, Damitha Asanga Gunawardane, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Mekdes Kondale Gurara, Alemu Guta, Parham Habibzadeh, Atlas Haddadi Avval, Nima Hafezi-Nejad, Adel Hajj Ali, Arvin Haj-Mirzaian, Esam S Halboub, Aram Halimi, Rabih Halwani, Randah R Hamadeh, Sajid Hameed, Samer Hamidi, Asif Hanif, Sanam Hariri, Netanja I Harlianto, Josep Maria Haro, Risky Kusuma Hartono, Ahmed I Hasaballah, S M Mahmudul Hasan, Hamidreza Hasani, Seyedeh Melika Hashemi, Abbas M Hassan, Soheil Hassanipour, Khezar Hayat, Golnaz Heidari, Mohammad Heidari, Zahra Heidarymeybodi, Brenda Yuliana Herrera-Serna, Claudiu Herteliu, Kamal Hezam, Yuta Hiraike, Mbuzeleni Mbuzeleni Hlongwa, Ramesh Holla, Marianne Holm, Nobuyuki Horita, Mohammad Hoseini, Md Mahbub Hossain, Mohammad Bellal Hossain Hossain, Mohammad-Salar Hosseini, Ali Hosseinzadeh, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Junjie Huang, Fernando N Hugo, Ayesha Humayun, Salman Hussain, Nawfal R Hussein, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Pulwasha Maria Iftikhar, Kevin S Ikuta, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Mustapha Immurana, Kaire Innos, Pooya Iranpour, Lalu Muhammad Irham, Md Shariful Islam, Rakibul M Islam, Farhad Islami, Nahlah Elkudssiah Ismail, Gaetano Isola, Masao Iwagami, Linda Merin J, Abhishek Jaiswal, Mihajlo Jakovljevic, Mahsa Jalili, Shahram Jalilian, Elham Jamshidi, Sung-In Jang, Chinmay T Jani, Tahereh Javaheri, Umesh Umesh Jayarajah, Shubha Jayaram, Seyed Behzad Jazayeri, Rime Jebai, Bedru Jemal, Wonjeong Jeong, Ravi Prakash Jha, Har Ashish Jindal, Yetunde O John-Akinola, Jost B Jonas, Tamas Joo, Nitin Joseph, Farahnaz Joukar, Jacek Jerzy Jozwiak, Mikk Jürisson, Ali Kabir, Salah Eddine Oussama Kacimi, Vidya Kadashetti, Farima Kahe, Pradnya Vishal Kakodkar, Laleh R Kalankesh, Leila R Kalankesh, Rohollah Kalhor, Vineet Kumar Kamal, Farin Kamangar, Ashwin Kamath, Tanuj Kanchan, Eswar Kandaswamy, Himal Kandel, HyeJung Kang, Girum Gebremeskel Kanno, Neeti Kapoor, Sitanshu Sekhar Kar, Shama D Karanth, Ibraheem M Karaye, André Karch, Amirali Karimi, Bekalu Getnet Kassa, Patrick DMC Katoto, Joonas H Kauppila, Harkiran Kaur, Abinet Gebremickael Kebede, Leila Keikavoosi-Arani, Gemechu Gemechu Kejela, Phillip M Kemp Bohan, Maryam Keramati, Mohammad Keykhaei, Himanshu Khajuria, Abbas Khan, Abdul Aziz Khan Khan, Ejaz Ahmad Khan, Gulfaraz Khan, Md Nuruzzaman Khan, Moien AB Khan, Javad Khanali, Khaled Khatab, Moawiah Mohammad Khatatbeh, Mahalaqua Nazli Khatib, Maryam Khayamzadeh, Hamid Reza Khayat Kashani, Mohammad Amin Khazeei Tabari, Mehdi Khezeli, Mahmoud Khodadost, Min Seo Kim, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Miloslav Klugar, Jitka Klugarová, Ali-Asghar Kolahi, Pavel Kolkhir, Farzad Kompani, Parvaiz A Koul, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Kewal Krishan, Yuvaraj Krishnamoorthy, Burcu Kucuk Bicer, Nuworza Kugbey, Mukhtar Kulimbet, Akshay Kumar, G Anil Kumar, Narinder Kumar, Om P Kurmi, Ambily Kuttikkattu, Carlo La Vecchia, Arista Lahiri, Dharmesh Kumar Lal, Judit Lám, Qing Lan, Iván Landires, Bagher Larijani, Savita Lasrado, Jerrald Lau, Paolo Lauriola, Caterina Ledda, Sang-woong Lee, Shaun Wen Huey Lee, Wei-Chen Lee, Yeong Yeh Lee, Yo Han Lee, Samson Mideksa Legesse, James Leigh, Elvynna Leong, Ming-Chieh Li, Stephen S Lim, Gang Liu, Jue Liu, Chun-Han Lo, Ayush Lohiya, Platon D Lopukhov, László Lorenzovici, Mojgan Lotfi, Joana A Loureiro, Raimundas Lunevicius, Farzan Madadizadeh, Ahmad R Mafi, Sameh Magdeldin, Soleiman Mahjoub, Ata Mahmoodpoor, Morteza Mahmoudi, Marzieh Mahmoudimanesh, Rashidul Alam Mahumud, Azeem Majeed, Jamal Majidpoor, Alaa Makki, Konstantinos Christos Makris, Elaheh Malakan Rad, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Tauqeer Hussain Mallhi, Sneha Deepak Mallya, Mohammed A Mamun, Ana Laura Manda, Fariborz Mansour-Ghanaei, Borhan Mansouri, Mohammad Ali Mansournia, Lorenzo Giovanni Mantovani, Santi Martini, Miquel Martorell, Sahar Masoudi, Seyedeh Zahra Masoumi, Clara N Matei, Elezebeth Mathews, Manu Raj Mathur, Vasundhara Mathur, Martin McKee, Jitendra Kumar Meena, Khalid Mehmood, Entezar Mehrabi Nasab, Ravi Mehrotra, Addisu Melese, Walter Mendoza, Ritesh G Menezes, SIsay Derso Mengesha, Laverne G Mensah, Alexios-Fotios A Mentis, Andry Yasmid Mera Mera-Mamián, Tuomo J Meretoja, Mehari Woldemariam Merid, Amanual Getnet Mersha, Belsity Temesgen Meselu, Mahboobeh Meshkat, Tomislav Mestrovic, Junmei Miao Jonasson, Tomasz Miazgowski, Irmina Maria Michalek, Gelana Fekadu Worku Mijena, Ted R Miller, Shabir Ahmad Mir, Seyed Kazem Mirinezhad, Seyyedmohammadsadeq Mirmoeeni, Mohammad Mirza-Aghazadeh-Attari, Hamed Mirzaei, Hamid Reza Mirzaei, Abay Sisay Misganaw, Sanjeev Misra, Karzan Abdulmuhsin Mohammad, Esmaeil Mohammadi, Mokhtar Mohammadi, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Arif Mohammed, Shafiu Mohammed, Syam Mohan, Mohammad Mohseni, Nagabhishek Moka, Ali H Mokdad, Alex Molassiotis, Mariam Molokhia, Kaveh Momenzadeh, Sara Momtazmanesh, Lorenzo Monasta, Ute Mons, Ahmed Al Montasir, Fateme Montazeri, Arnulfo Montero, Mohammad Amin Moosavi, Abdolvahab Moradi, Yousef Moradi, Mostafa Moradi Sarabi, Paula Moraga, Lidia Morawska, Shane Douglas Morrison, Jakub Morze, Abbas Mosapour, Ebrahim Mostafavi, Seyyed Meysam Mousavi, Haleh Mousavi Isfahani, Amin Mousavi Khaneghah, Christine Mpundu-Kaambwa, Sumaira Mubarik, Francesk Mulita, Daniel Munblit, Sandra B Munro, Efrén Murillo-Zamora, Jonah Musa, Ashraf F Nabhan, Ahamarshan Jayaraman Nagarajan, Shankar Prasad Nagaraju, Gabriele Nagel, Mohammadreza Naghipour, Mukhammad David Naimzada, Tapas Sadasivan Nair, Atta Abbas Naqvi, Sreenivas Narasimha Swamy, Aparna Ichalangod Narayana, Hasan Nassereldine, Zuhair S Natto, Biswa Prakash Nayak, Rawlance Ndejjo, Sabina Onyinye Nduaguba, Wogene Wogene Negash, Seyed Aria Nejadghaderi, Kazem Nejati, Sandhya Neupane Kandel, Huy Van Nguyen Nguyen, Robina Khan Niazi, Nurulamin M Noor, Maryam Noori, Nafise Noroozi, Hasti Nouraei, Ali Nowroozi, Virginia Nuñez-Samudio, Chimezie Igwegbe Nzoputam, Ogochukwu Janet Nzoputam, Bogdan Oancea, Oluwakemi Ololade Odukoya, Onome Bright Oghenetega, Ropo Ebenezer Ogunsakin, Ayodipupo Sikiru Oguntade, In-Hwan Oh, Hassan Okati-Aliabad, Akinkunmi Paul Okekunle, Andrew T Olagunju, Tinuke O Olagunju, Babayemi Oluwaseun Olakunde, Isaac Iyinoluwa Olufadewa, Emad Omer, Abidemi E Emmanuel Omonisi, Sokking Ong, Obinna E Onwujekwe, Hans Orru, Stanislav S Otstavnov, Abderrahim Oulhaj, Bilcha Oumer, Oluwatomi Funbi Owopetu, Babatunji Emmanuel Oyinloye, Mahesh P A, Alicia Padron-Monedero, Jagadish Rao Padubidri, Babak Pakbin, Keyvan Pakshir, Reza Pakzad, Tamás Palicz, Adrian Pana, Anamika Pandey, Ashok Pandey, Suman Pant, Shahina Pardhan, Eun-Cheol Park, Eun-Kee Park, Seoyeon Park, Jay Patel, Siddhartha Pati, Rajan Paudel, Uttam Paudel, Mihaela Paun, Hamidreza Pazoki Toroudi, Minjin Peng, Jeevan Pereira, Renato B Pereira, Simone Perna, Navaraj Perumalsamy, Richard G Pestell, Raffaele Pezzani, Cristiano Piccinelli, Julian David Pillay, Zahra Zahid Piracha, Tobias Pischon, Maarten J Postma, Ashkan Pourabhari Langroudi, Akram Pourshams, Naeimeh Pourtaheri, Akila Prashant, Mirza Muhammad Fahd Qadir, Zahiruddin Quazi Syed, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Raghu Anekal Radhakrishnan, Venkatraman Radhakrishnan, Mojtaba Raeisi, Ata Rafiee, Alireza Rafiei, Nasiru Raheem, Fakher Rahim, Md Obaidur Rahman, Mosiur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Shayan Rahmani, Vahid Rahmanian, Nazanin Rajai, Aashish Rajesh, Pradhum Ram, Kiana Ramezanzadeh, Juwel Rana, Kamal Ranabhat, Priyanga Ranasinghe, Chythra R Rao, Sowmya J Rao, Sina Rashedi, Amirfarzan Rashidi, Mahsa Rashidi, Mohammad-Mahdi Rashidi, Zubair Ahmed Ratan, David Laith Rawaf, Salman Rawaf, Lal Rawal, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Ashfaq Ur Rehman, Inayat ur Rehman, Marissa B Reitsma, Andre M N Renzaho, Maryam Rezaei, Nazila Rezaei, Negar Rezaei, Nima Rezaei, Saeid Rezaei, Mohsen Rezaeian, Aziz Rezapour, Abanoub Riad, Reza Rikhtegar, Maria Rios-Blancas, Thomas J Roberts, Peter Rohloff, Esperanza Romero-Rodríguez, Gholamreza Roshandel, Godfrey M Rwegerera, Manjula S, Maha Mohamed Saber-Ayad, Bahar Saberzadeh-Ardestani, Siamak Sabour, Basema Saddik, Erfan Sadeghi, Mohammad Reza Saeb, Umar Saeed, Mohsen Safaei, Azam Safary, Maryam Sahebazzamani, Amirhossein Sahebkar, Harihar Sahoo, Mirza Rizwan Sajid, Hedayat Salari, Sana Salehi, Marwa Rashad Salem, Hamideh Salimzadeh, Yoseph Leonardo Samodra, Abdallah M Samy, Juan Sanabria, Senthilkumar Sankararaman, Francesco Sanmarchi, Milena M Santric-Milicevic, Muhammad Arif Nadeem Saqib, Arash Sarveazad, Fatemeh Sarvi, Brijesh Sathian, Maheswar Satpathy, Nicolas Sayegh, Ione Jayce Ceola Schneider, Michaël Schwarzinger, Mario Šekerija, Subramanian Senthilkumaran, Sadaf G Sepanlou, Allen Seylani, Kenbon Seyoum, Feng Sha, Omid Shafaat, Pritik A Shah, Saeed Shahabi, Izza Shahid, Mohammad Amin Shahrbaf, Hamid R Shahsavari, Masood Ali Shaikh, Mohammed Feyisso Shaka, Elaheh Shaker, Mohammed Shannawaz, Mequannent Melaku Sharew Sharew, Azam Sharifi, Javad Sharifi-Rad, Purva Sharma, Bereket Beyene Shashamo, Aziz Sheikh, Mahdi Sheikh, Sara Sheikhbahaei, Rahim Ali Sheikhi, Ali Sheikhy, Peter Robin Shepherd, Adithi Shetty, Jeevan K Shetty, Ranjitha S Shetty, Kenji Shibuya, Reza Shirkoohi, Hesamaddin Shirzad-Aski, K M Shivakumar, Siddharudha Shivalli, Velizar Shivarov, Parnian Shobeiri, Zahra Shokri Varniab, Seyed Afshin Shorofi, Sunil Shrestha, Migbar Mekonnen Sibhat, Sudeep K Siddappa Malleshappa, Negussie Boti Sidemo, Diego Augusto Santos Silva, Luís Manuel Lopes Rodrigues Silva, Guilherme Silva Julian, Nicola Silvestris, Wudneh Simegn, Achintya Dinesh Singh, Ambrish Singh, Garima Singh, Harpreet 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Kenny Thomas, Jansje Henny Vera Ticoalu, Amir Tiyuri, Daniel Nigusse Tollosa, Roman Topor-Madry, Mathilde Touvier, Marcos Roberto Tovani-Palone, Eugenio Traini, Mai Thi Ngoc Tran, Jaya Prasad Tripathy, Gebresilasea Gendisha Ukke, Irfan Ullah, Saif Ullah, Sana Ullah, Bhaskaran Unnikrishnan, Marco Vacante, Maryam Vaezi, Sahel Valadan Tahbaz, Pascual R Valdez, Constantine Vardavas, Shoban Babu Varthya, Siavash Vaziri, Diana Zuleika Velazquez, Massimiliano Veroux, Paul J Villeneuve, Francesco S Violante, Sergey Konstantinovitch Vladimirov, Vasily Vlassov, Bay Vo, Linh Gia Vu, Abdul Wadood Wadood, Yasir Waheed, Mandaras Tariku Walde, Richard G Wamai, Cong Wang, Fang Wang, Ning Wang, Yu Wang, Paul Ward, Abdul Waris, Ronny Westerman, Nuwan Darshana Wickramasinghe, Melat Woldemariam, Berhanu Woldu, Hong Xiao, Suowen Xu, Xiaoyue Xu, Lalit Yadav, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Fereshteh Yazdanpanah, Yigizie Yeshaw, Yazachew Yismaw, Naohiro Yonemoto, Mustafa Z Younis, Zabihollah 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Thomas, N, Ticoalu, J, Tiyuri, A, Tollosa, D, Topor-Madry, R, Touvier, M, Tovani-Palone, M, Traini, E, Tran, M, Tripathy, J, Ukke, G, Ullah, I, Ullah, S, Unnikrishnan, B, Vacante, M, Vaezi, M, Valadan Tahbaz, S, Valdez, P, Vardavas, C, Varthya, S, Vaziri, S, Velazquez, D, Veroux, M, Villeneuve, P, Violante, F, Vladimirov, S, Vlassov, V, Vo, B, Vu, L, Wadood, A, Waheed, Y, Walde, M, Wamai, R, Wang, C, Wang, F, Wang, N, Wang, Y, Ward, P, Waris, A, Westerman, R, Wickramasinghe, N, Woldemariam, M, Woldu, B, Xiao, H, Xu, S, Xu, X, Yadav, L, Yahyazadeh Jabbari, S, Yang, L, Yazdanpanah, F, Yeshaw, Y, Yismaw, Y, Yonemoto, N, Younis, M, Yousefi, Z, Yousefian, F, Yu, C, Yu, Y, Yunusa, I, Zahir, M, Zaki, N, Zaman, B, Zangiabadian, M, Zare, F, Zare, I, Zareshahrabadi, Z, Zarrintan, A, Zastrozhin, M, Zeineddine, M, Zhang, D, Zhang, J, Zhang, Y, Zhang, Z, Zhou, L, Zodpey, S, Zoladl, M, Vos, T, Hay, S, Force, L, Murray, C, Epidemiologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Bill & Melinda Gates Foundation, Kuwait University (Kuwait), Ministry of Higher Education (Malasia), Lega Italiana per la Lotta ai Tumori, Health Effects Institute (Estados Unidos), Unión Europea. Comisión Europea. European Research Council (ERC), Unión Europea. Comisión Europea. H2020, Fundação para a Ciência e Tecnologia (Portugal), African-German Network of Excellence in Science (AGNES), Federal Ministry of Education & Research (Alemania), Alexander von Humboldt Foundation, Novo Nordisk Foundation, National Institute for Health Research (Reino Unido), National Health and Medical Research Council (Australia), Romanian National Authority for Scientific Research and Innovation, Romanian Ministry of Research Innovation and Digitalization, Ministry of Education, Science and Technological Development (Serbia), Sigrid Jusélius Foundation, Finnish Cancer Foundation, Datta Meghe Institute of Medical Sciences (India), Xiamen University (Malasia), Manipal Academy of Higher Education (India), Panjab University (India), Sistema Nacional de Investigación (Panamá), Secretaría Nacional de Ciencia, Tecnología e Innovación (Panamá), Ministry of Science and Technology (Taiwan), Lung Foundation Australia, National Natural Science Foundation of China, Wellcome Trust, UNSW Sydney (Australia), ICMR - National Institute of Epidemiology (India), University of Tasmania (Australia), National Council for Scientific and Technological Development (Brasil), Coordenação de Aperfeicoamento de Pessoal de Nível Superior (Brasil), Institute for Advanced Studies in Basic Sciences (Irán), Ain Shams University (Egipto), International Center of Medical Sciences Research (Islamabad), National Institutes of Health (Estados Unidos), University of Oxford (Reino Unido), National Institute of Genetic Engineering and Biotechnology (Irán), Marga und Walter Boll - Stiftung, Ministero della Salute (Italia), IRCCS Materno Infantile Burlo Garofolo (Italia), King College London, Wellcome Trust/DBT India Alliance (India), Public Health, University of St Andrews. School of Medicine, and University of St Andrews. Population and Behavioural Science Division
Subjects: Male, DEATHS, DALY, cancer, risk factors, Medizin, systematic analysis, Global Health, Risk Assessment, Cancer prevention, Global Burden of Disease, RC0254, Risk-attributable cancer deaths, SDG 3 - Good Health and Well-being, RA0421, Risk Factors, RA0421 Public health. Hygiene. Preventive Medicine, Quality-Adjusted Life Year, Neoplasms, cancer, Humans, Global Burden of Disease Study, UK, Medicine(all), MCC, RC0254 Neoplasms. Tumors. Oncology (including Cancer), Risk Factor, Smoking, COVID-19, 3rd-DAS, General Medicine, Disability-adjusted life-years, SOCIAL DETERMINANTS, Risk assessments, risk factor, Cardiovascular and Metabolic Diseases, 3121 General medicine, internal medicine and other clinical medicine, OBESITY, Cancer burden, Neoplasm, Female, LIFE-STYLE, Quality-Adjusted Life Years, HEALTH, RA, Human, RC
Abstract: Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9-42·8] and 33·3% [25·8-42·0]). Interpretation: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. We are grateful to the surveillance systems, including cancer registries, that generated and shared observed cancer burden data. S M Aljunid acknowledges the Department of Health Policy and Management, College of Public Health, Kuwait University for the approval and support to participate in this research project. H Ariffin acknowledges support from the Ministry of Higher Education, Malaysia (grant FRGS/1/2021/SKK0/UM/01/1). F Barra acknowledges support from Lega Italiana per la Lotta contro i Tumori - LILT - Bando 5 x 1000 anno 2019. L Belo and M Carvalho acknowledge the support from FCT in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of UCIBIO and the project LA/P/0140/2020 of i4HB. A J Cohen was supported by the Health Effects Institute, Boston, MA, USA. J Conde acknowledges financial support from the European Research Council - ERC Starting Grant 848325. V M Costa acknowledges her grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006. T C Ekundayo was supported by the African-German Network of Excellence in Science (AGNES), the Federal Ministry of Education and Research (BMBF) and the Alexander von Humboldt Foundation (AvH). N Ghith acknowledges support from a grant from Novo Nordisk Foundation (NNF16OC0021856). J C Glasbey is support by a Doctoral Research Fellowship from the National Institute of Health Research (NIHR300175). V K Gupta and V B Gupta acknowledge funding support from National Health and Medical Research Council (NHMRC), Australia. C Herteliu, A Pana, and M Ausloos acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. C Herteliu is also partially supported by a grant of the Romanian Ministry of Research Innovation and Digitalization, MCID, project number ID-585-CTR-42-PFE-2021. S Hussain was supported from Operational Programme Research, Development and Education–Project, Postdoc2MUNI (number CZ.02.2. 69/0.0/0.0/18_053/0016952). M Jakovljevic acknowledges partial support through the grant OI 175 014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. J H Kauppila acknowledges research grants from Sigrid Jusélius Foundation and the Finnish Cancer Foundation. M N Khatib acknowledges support from Datta Meghe Institute of Medical Sciences (deemed-to-be-university). Y J Kim was supported by the Research Management Centre, Xiamen University Malaysia [XMUMRF/2020-C6/ITCM/0004]. S L Koulmane Laxminarayana acknowledges institutional assistance by Manipal Academy of Higher Education, Manipal. K Krishan is supported by the UGC Centre of Advanced Study (Phase II), awarded to the Department of Anthropology, Panjab University, Chandigarh, India. I Landires is a member of the Sistema Nacional de Investigación (SNI), which is supported by Panama’s Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT). M-C Li was supported by the Ministry of Science and Technology, Taiwan (MOST 110-2314-B-003-001). G Liu acknowledges support from the CREATE Hope scientific fellowship from Lung Foundation Australia. J Liu acknowledges support from the National Natural Science Foundation (72122001). J A Loureiro was supported by Scientific Employment Stimulus (FCT; CEECINST/00049/2018). E Mathews is supported by a Clinical and Public Health Early Career Fellowship (grant number IA/CPHE/17/1/503345) from the DBT India Alliance/Wellcome Trust Department of Biotechnology, India Alliance (2018–2023). T J Meretoja was supported by an unrestricted grant from Cancer Foundation Finland sr. S Mohammed acknowledges a fellowship grant from Alexander von Humboldt Foundation, outside the submitted work. M Molokhia is supported by the National Institute for Health Research Biomedical Research Center at Guy’s and St Thomas’ National Health Service Foundation Trust and King’s College London. L Monasta received support from the Italian Ministry of Health at the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste - Italy (RC 34/2017). U Mons is supported by the Marga and Walter Boll Foundation, Kerpen, Germany. M A Moosavi acknowledges the financial support of National Institute of Genetics Engineering and Biotechnology (NIGEB). J Musa acknowledges support from the NIH/FICK43TW011416 for research-protected time for cervical cancer research and career development at University of Jos. V Nuñez-Samudio is a member of the Sistema Nacional de Investigación (SNI), which is supported by Panama’s Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT). O O Odukoya acknowledges support by the Fogarty International Center of the National Institutes of Health under the award number K43TW010704 for research-protected time. The content is solely the responsibility of all the authors and does not necessarily represent the official views of the National Institutes of Health. A S Oguntade acknowledges funding by a doctoral scholarship from the Nuffield Department of Population Health, University of Oxford (Oxford Population Health). J R Padubidri acknowledges Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal for their constant support in research collaborations. R G Pestell acknowledges support from NIH grant W81XWH1810605 Breast Cancer Research, Breakthrough Grant R21 CA235139-01. Z Z Piracha acknowledges the International Center of Medical Sciences Research (ICMSR), Islamabad (44000), Pakistan. R A Radhakrishnan acknowledges support from Wellcome Trust/DBT India Alliance - IA/CPHI/18/1/503927. U Saeed acknowledges the International Center of Medical Sciences Research (ICMSR), Islamabad, Pakistan. A M Samy acknowledges the support from Ain Shams University and the Egyptian Fulbright Mission Program. F Sha was supported by the Shenzhen Science and Technology Program (grant number KQTD20190929172835662). H R Shahsavari acknowledges the Institute for Advanced Studies in Basic Sciences (IASBS) Research Council. A Shetty acknowledges Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal for all the academic support. D A S Silva acknowledges financing in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil (CAPES)—Finance Code 001 and D A S Silva is supported in part by CNPq-Brazil (309589/2021-5). L M L R Silva was supported by project CENTRO-04-3559-FSE-000162, Fundo Social Europeu (FSE). Am Singh is supported by the International Graduate Research Scholarship, University of Tasmania. R Suliankatchi Abdulkader acknowledges support from ICMR—National Institute of Epidemiology. B Unnikrishnan acknowledges Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal. H Xiao acknowledges support from the Public Health Sciences Division of the Fred Hutchinson Cancer Research Center. X Xu is supported by the University of New South Wales (Australia) Scientia Program. C Yu was supported by the National Natural Science Foundation of China (grant number 82173626) and Wuhan Medical Research Program of Joint Fund of Hubei Health Committee (grant number WJ2019H304). Sí
Published: 2022

63. The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Author: Elysia M Alvarez, Lisa M Force, Rixing Xu, Kelly Compton, Dan Lu, Hannah Jacqueline Henrikson, Jonathan M Kocarnik, James D Harvey, Alyssa Pennini, Frances E Dean, Weijia Fu, Martina T Vargas, Theresa H M Keegan, Hany Ariffin, Ronald D Barr, Yana Arturovna Erdomaeva, D Sanjeeva Gunasekera, Yetunde O John-Akinola, Tyler G Ketterl, Tezer Kutluk, Marcio Henrique Malogolowkin, Prashant Mathur, Venkatraman Radhakrishnan, Lynn Ann Gloeckler Ries, Carlos Rodriguez-Galindo, Garik Barisovich Sagoyan, Iyad Sultan, Behzad Abbasi, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Michael Abdelmasseh, Sherief Abd-Elsalam, Amir Abdoli, Haimanot Abebe, Aidin Abedi, Hassan Abidi, Hassan Abolhassani, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Basavaprabhu Achappa, Juan Manuel Acuna, Isaac Akinkunmi Adedeji, Oyelola A Adegboye, Qorinah Estiningtyas Sakilah Adnani, Shailesh M Advani, Muhammad Sohail Afzal, Mohamad Aghaie Meybodi, Bahman Ahadinezhad, Bright Opoku Ahinkorah, Sajjad Ahmad, Sepideh Ahmadi, Muktar Beshir Ahmed, Tarik Ahmed Rashid, Yusra Ahmed Salih, Wajeeha Aiman, Gizachew Taddesse Akalu, Hanadi Al Hamad, Fares Alahdab, Abdulhadi A AlAmodi, Fahad Mashhour Alanezi, Turki M Alanzi, Adugnaw Zeleke Alem, Dejene Tsegaye Alem, Yosef Alemayehu, Fadwa Naji Alhalaiqa, Robert Kaba Alhassan, Saqib Ali, Gianfranco Alicandro, Vahid Alipour, Syed Mohamed Aljunid, Motasem Alkhayyat, Sunitha Alluri, Nihad A Almasri, Sadeq Ali Al-Maweri, Sami Almustanyir, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Edward Kwabena Ameyaw, Saeed Amini, Hubert Amu, Robert Ancuceanu, Catalina Liliana Andrei, Tudorel Andrei, Fereshteh Ansari, Alireza Ansari-Moghaddam, Davood Anvari, Anayochukwu Edward Anyasodor, Jalal Arabloo, Morteza Arab-Zozani, Ayele Mamo Argaw, Muhammad Arshad, Judie Arulappan, Armin Aryannejad, Zatollah Asemi, Mohammad Asghari Jafarabadi, Mohammad Reza Atashzar, Prince Atorkey, Alok Atreya, Sameh Attia, Avinash Aujayeb, Marcel Ausloos, Leticia Avila-Burgos, Atalel Fentahun Awedew, Beatriz Paulina Ayala Quintanilla, Alemu Degu Ayele, Solomon Shitu Ayen, Mohammed A Azab, Sina Azadnajafabad, Hiva Azami, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Ghasem Azarian, Ahmed Y Azzam, Saeed Bahadory, Jianjun Bai, Atif Amin Baig, Jennifer L Baker, Maciej Banach, Till Winfried Bärnighausen, Francesco Barone-Adesi, Fabio Barra, Amadou Barrow, Huda Basaleem, Abdul-Monim Mohammad Batiha, Masoud Behzadifar, Niguss Cherie Bekele, Rebuma Belete, Uzma Iqbal Belgaumi, Arielle Wilder Bell, Alemshet Yirga Berhie, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Nikha Bhardwaj, Pankaj Bhardwaj, Sonu Bhaskar, Krittika Bhattacharyya, Vijayalakshmi S Bhojaraja, Sadia Bibi, Ali Bijani, Antonio Biondi, Setognal Birara, Tone Bjørge, Obasanjo Afolabi Bolarinwa, Srinivasa Rao Bolla, Archith Boloor, Dejana Braithwaite, Hermann Brenner, Norma B Bulamu, Katrin Burkart, Maria Teresa Bustamante-Teixeira, Nadeem Shafique Butt, Zahid A Butt, Florentino Luciano Caetano dos Santos, Chao Cao, Yin Cao, Giulia Carreras, Ferrán Catalá-López, Francieli Cembranel, Ester Cerin, Raja Chandra Chakinala, Promit Ananyo Chakraborty, Vijay Kumar Chattu, Pankaj Chaturvedi, Akhilanand Chaurasia, Prachi P Chavan, Odgerel Chimed-Ochir, Jee-Young Jasmine Choi, Devasahayam J Christopher, Dinh-Toi Chu, Michael T Chung, Joao Conde, Vera Marisa Costa, Omar B Da'ar, Omid Dadras, Saad M A Dahlawi, Xiaochen Dai, Giovanni Damiani, Emanuele D'Amico, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, Amira Hamed Darwish, Ahmad Daryani, Fernando Pio De la Hoz, Sisay Abebe Debela, Takele Gezahegn G Demie, Getu Debalkie Demissie, Zeleke Geto Demissie, Edgar Denova-Gutiérrez, Meseret Derbew Molla, Rupak Desai, Abebaw Alemayehu Desta, Deepak Dhamnetiya, Samath Dhamminda Dharmaratne, Mandira Lamichhane Dhimal, Meghnath Dhimal, Mostafa Dianatinasab, Mojtaba Didehdar, Mengistie Diress, Shirin Djalalinia, Huyen Phuc Do, Saeid Doaei, Fariba Dorostkar, Wendel Mombaque dos Santos, Thomas M Drake, Michael Ekholuenetale, Iman El Sayed, Maysaa El Sayed Zaki, Maha El Tantawi, Hassan El-Abid, Mostafa Ahmed Elbahnasawy, Iffat Elbarazi, Hala Rashad Elhabashy, Muhammed Elhadi, Shaimaa I El-Jaafary, Daniel Berhanie Enyew, Ryenchindorj Erkhembayar, Babak Eshrati, Sharareh Eskandarieh, Mohammed Faisaluddin, Jawad Fares, Umar Farooque, Abidemi Omolara Fasanmi, Wafa Fatima, José Miguel P Ferreira de Oliveira, Simone Ferrero, Lorenzo Ferro Desideri, Getahun Fetensa, Irina Filip, Florian Fischer, James L Fisher, Masoud Foroutan, Takeshi Fukumoto, Peter Andras Gaal, Mohamed M Gad, Piyada Gaewkhiew, Silvano Gallus, Tushar Garg, Teferi Gebru Gebremeskel, Belete Negese Belete Gemeda, Tamiru Getachew, Mansour Ghafourifard, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Fariba Ghassemi, Nermin Ghith, Ali Gholami, Jamshid Gholizadeh Navashenaq, Syed Amir Gilani, Themba G Ginindza, Abraham Tamirat Gizaw, James C Glasbey, Amit Goel, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Sameer Vali Gopalani, Giuseppe Gorini, Houman Goudarzi, Bárbara Niegia Garcia Goulart, Ayman Grada, Mohammed Ibrahim Mohialdeen Gubari, Maximiliano Ribeiro Guerra, Avirup Guha, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Nima Hafezi-Nejad, Alemayehu Hailu, Arvin Haj-Mirzaian, Rabih Halwani, Randah R Hamadeh, Mitiku Teshome Hambisa, Sajid Hameed, Samer Hamidi, Shafiul Haque, Sanam Hariri, Josep Maria Haro, Ahmed I Hasaballah, S M Mahmudul Hasan, Seyedeh Melika Hashemi, Treska S Hassan, Soheil Hassanipour, Simon I Hay, Khezar Hayat, Sultan H Hebo, Golnaz Heidari, Mohammad Heidari, Brenda Yuliana Herrera-Serna, Claudiu Herteliu, Demisu Zenbaba Heyi, Kamal Hezam, Michael K Hole, Ramesh Holla, Nobuyuki Horita, Md Mahbub Hossain, Mohammad Bellal Hossain, Mohammad-Salar Hosseini, Mostafa Hosseini, Ali Hosseinzadeh, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Mohamed Hsairi, Junjie Huang, Nawfal R Hussein, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Kaire Innos, Lalu Muhammad Irham, Rakibul M Islam, Sheikh Mohammed Shariful Islam, Nahlah Elkudssiah Ismail, Gaetano Isola, Masao Iwagami, Louis Jacob, Farhad Jadidi-Niaragh, Vardhmaan Jain, Mihajlo Jakovljevic, Roksana Janghorban, Amirreza Javadi Mamaghani, Shubha Jayaram, Ranil Jayawardena, Seyed Behzad Jazayeri, Rime Jebai, Ravi Prakash Jha, Tamas Joo, Nitin Joseph, Farahnaz Joukar, Mikk Jürisson, Billingsley Kaambwa, Ali Kabir, Leila R Kalankesh, Feroze Kaliyadan, Zul Kamal, Ashwin Kamath, Himal Kandel, Sitanshu Sekhar Kar, Ibraheem M Karaye, Amirali Karimi, Bekalu Getnet Kassa, Joonas H Kauppila, Phillip M Kemp Bohan, Andre Pascal Kengne, Amene Abebe Kerbo, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Nastaran Khalili, Neda Khalili, Ejaz Ahmad Khan, Gulfaraz Khan, Maseer Khan, Md Nuruzzaman Khan, Moien AB Khan, Javad Khanali, Maryam Khayamzadeh, Omid Khosravizadeh, Jagdish Khubchandani, Roba Khundkar, Min Seo Kim, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Katarzyna Kissimova-Skarbek, Ali-Asghar Kolahi, Jacek A Kopec, Rajasekaran Koteeswaran, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Nuworza Kugbey, G Anil Kumar, Nithin Kumar, Alexander Kwarteng, Carlo La Vecchia, Qing Lan, Iván Landires, Savita Lasrado, Paolo Lauriola, Caterina Ledda, Sang-woong Lee, Wei-Chen Lee, Yeong Yeh Lee, Yo Han Lee, James Leigh, Elvynna Leong, Bingyu Li, Jiarui Li, Ming-Chieh Li, Stephen S Lim, Xuefeng Liu, Stany W Lobo, Joana A Loureiro, Alessandra Lugo, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Morteza Mahmoudi, Azeem Majeed, Alaa Makki, Shilpa Male, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Mohammed A Mamun, Navid Manafi, Fariborz Mansour-Ghanaei, Borhan Mansouri, Mohammad Ali Mansournia, Santi Martini, Seyedeh Zahra Masoumi, Clara N Matei, Manu Raj Mathur, Colm McAlinden, Ravi Mehrotra, Walter Mendoza, Ritesh G Menezes, Alexios-Fotios A Mentis, Tuomo J Meretoja, Amanual Getnet Mersha, Mohamed Kamal Mesregah, Tomislav Mestrovic, Junmei Miao Jonasson, Bartosz Miazgowski, Irmina Maria Michalek, Ted R Miller, Alemu Basazin Mingude, Seyyedmohammadsadeq Mirmoeeni, Hamed Mirzaei, Sanjeev Misra, Prasanna Mithra, Karzan Abdulmuhsin Mohammad, Mokhtar Mohammadi, Seyyede Momeneh Mohammadi, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Arif Mohammed, Shafiu Mohammed, Teroj Abdulrahman Mohammed, Nagabhishek Moka, Ali H Mokdad, Mariam Molokhia, Sara Momtazmanesh, Lorenzo Monasta, Mohammad Ali Moni, Ghobad Moradi, Yousef Moradi, Maliheh Moradzadeh, Rahmatollah Moradzadeh, Paula Moraga, Shane Douglas Morrison, Ebrahim Mostafavi, Amin Mousavi Khaneghah, Christine Mpundu-Kaambwa, Sumaira Mubarik, Lillian Mwanri, Ashraf F Nabhan, Shankar Prasad Nagaraju, Chie Nagata, Mohsen Naghavi, Mukhammad David Naimzada, Luigi Naldi, Vinay Nangia, Atta Abbas Naqvi, Sreenivas Narasimha Swamy, Aparna Ichalangod Narayana, Biswa Prakash Nayak, Vinod C Nayak, Javad Nazari, Sabina Onyinye Nduaguba, Ionut Negoi, Serban Mircea Negru, Seyed Aria Nejadghaderi, Samata Nepal, Sandhya Neupane Kandel, Haruna Asura Nggada, Cuong Tat Nguyen, Chukwudi A Nnaji, Hamed Nosrati, Hasti Nouraei, Ali Nowroozi, Virginia Nuñez-Samudio, Vincent Ebuka Nwatah, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Oluwakemi Ololade Odukoya, Ayodipupo Sikiru Oguntade, In-Hwan Oh, Andrew T Olagunju, Tinuke O Olagunju, Babayemi Oluwaseun Olakunde, Mojisola Morenike Oluwasanu, Emad Omar, Ahmed Omar Bali, Sokking Ong, Obinna E Onwujekwe, Doris V Ortega-Altamirano, Nikita Otstavnov, Stanislav S Otstavnov, Bilcha Oumer, Mayowa O Owolabi, Mahesh P A, Alicia Padron-Monedero, Jagadish Rao Padubidri, Keyvan Pakshir, Adrian Pana, Anamika Pandey, Shahina Pardhan, Fatemeh Pashazadeh Kan, Maja Pasovic, Jenil R Patel, Siddhartha Pati, Sanjay M Pattanshetty, Uttam Paudel, Renato B Pereira, Mario F P Peres, Arokiasamy Perianayagam, Maarten J Postma, Hadi Pourjafar, Akram Pourshams, Akila Prashant, Thejodhar Pulakunta, Mirza Muhammad Fahd Fahd Qadir, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Raghu Anekal Radhakrishnan, Ata Rafiee, Alireza Rafiei, Sima Rafiei, Fakher Rahim, Shadi Rahimzadeh, Mosiur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Aashish Rajesh, Vajiheh Ramezani-Doroh, Kamal Ranabhat, Priyanga Ranasinghe, Chythra R Rao, Sowmya J Rao, Sina Rashedi, Mahsa Rashidi, Mohammad-Mahdi Rashidi, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Lal Rawal, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Misganu Teshoma Regasa, Andre M N Renzaho, Maryam Rezaei, Negar Rezaei, Nima Rezaei, Mohsen Rezaeian, Aziz Rezapour, Sahba Rezazadeh-Khadem, Abanoub Riad, Ligia Estefania Rios Lopez, Jefferson Antonio Buendia Rodriguez, Luca Ronfani, Gholamreza Roshandel, Godfrey M Rwegerera, Maha Mohamed Saber-Ayad, Siamak Sabour, Basema Saddik, Erfan Sadeghi, Saeid Sadeghian, Umar Saeed, Amirhossein Sahebkar, KM Saif-Ur-Rahman, S Mohammad Sajadi, Sarvenaz Salahi, Sana Salehi, Marwa Rashad Salem, Hamideh Salimzadeh, Abdallah M Samy, Juan Sanabria, Francesco Sanmarchi, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Susan M Sawyer, Mete Saylan, Ione Jayce Ceola Schneider, Abdul-Aziz Seidu, Mario Šekerija, Endalew Gemechu Sendo, Sadaf G Sepanlou, Allen Seylani, Kenbon Seyoum, Feng Sha, Omid Shafaat, Masood Ali Shaikh, Erfan Shamsoddin, Mohammed Shannawaz, Rajesh Sharma, Sara Sheikhbahaei, Adithi Shetty, B Suresh Kumar Shetty, Pavanchand H Shetty, Jae Il Shin, Reza Shirkoohi, K M Shivakumar, Parnian Shobeiri, Soraya Siabani, Migbar Mekonnen Sibhat, Sudeep K Siddappa Malleshappa, Negussie Boti Sidemo, Diego Augusto Santos Silva, Guilherme Silva Julian, Achintya Dinesh Singh, Jasvinder A Singh, Jitendra Kumar Singh, Surjit Singh, Abiy H Sinke, Yitagesu Sintayehu, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Lee Smith, Ahmad Sofi-Mahmudi, Mohammad Sadegh Soltani-Zangbar, Suhang Song, Emma Elizabeth Spurlock, Paschalis Steiropoulos, Kurt Straif, Ranjeeta Subedi, Mu'awiyyah Babale Sufiyan, Rizwan Suliankatchi Abdulkader, Saima Sultana, Viktória Szerencsés, Miklós Szócska, Seidamir Pasha Tabaeian, Rafael Tabarés-Seisdedos, Mohammadreza Tabary, Takahiro Tabuchi, Hooman Tadbiri, Majid Taheri, Amir Taherkhani, Ken Takahashi, Mircea Tampa, Ker-Kan Tan, Vivian Y Tat, Ahmad Tavakoli, Abdelghani Tbakhi, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Fisaha Haile Tesfay, Bekele Tesfaye, Jarnail Singh Thakur, Rekha Thapar, Aravind Thavamani, Arulmani Thiyagarajan, Nihal Thomas, Ruoyan Tobe-Gai, Munkhsaikhan Togtmol, Seyed Abolfazl Tohidast, Hamid Reza Tohidinik, Musliu Adetola Tolani, Daniel Nigusse Tollosa, Mathilde Touvier, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Mai Thi Ngoc Tran, Jaya Prasad Tripathy, Biruk Shalmeno Tusa, Gebresilasea Gendisha Ukke, Irfan Ullah, Saif Ullah, Krishna Kishore Umapathi, Bhaskaran Unnikrishnan, Era Upadhyay, Tolassa Wakayo Ushula, Marco Vacante, Sahel Valadan Tahbaz, Shoban Babu Varthya, Massimiliano Veroux, Paul J Villeneuve, Francesco S Violante, Vasily Vlassov, Giang Thu Vu, Yasir Waheed, Ning Wang, Paul Ward, Adisu Birhanu Weldesenbet, Yi Feng Wen, Ronny Westerman, Andrea Sylvia Winkler, Befikadu Legesse Wubishet, Suowen Xu, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Sanni Yaya, Vahid Yazdi-Feyzabadi, Taklo Simeneh Yazie, Sisay Shewasinad Yehualashet, Alex Yeshaneh, Yigizie Yeshaw, Birhanu Wubale Yirdaw, Naohiro Yonemoto, Mustafa Z Younis, Zabihollah Yousefi, Chuanhua Yu, Ismaeel Yunusa, Vesna Zadnik, Mazyar Zahir, Telma Zahirian Moghadam, Mohammad Zamani, Maryam Zamanian, Hamed Zandian, Fariba Zare, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Jianrong Zhang, Zhi-Jiang Zhang, Arash Ziapour, Mohammad Zoladl, Christopher J L Murray, Christina Fitzmaurice, Archie Bleyer, Nickhill Bhakta, Alvarez E.M., Force L.M., Xu R., Compton K., Lu D., Henrikson H.J., Kocarnik J.M., Harvey J.D., Pennini A., Dean F.E., Fu W., Vargas M.T., Keegan T.H.M., Ariffin H., Barr R.D., Erdomaeva Y.A., Gunasekera D.S., John-Akinola Y.O., Ketterl T.G., Kutluk T., Malogolowkin M.H., Mathur P., Radhakrishnan V., Ries L.A.G., Rodriguez-Galindo C., Sagoyan G.B., Sultan I., Abbasi B., Abbasi-Kangevari M., Abbasi-Kangevari Z., Abbastabar H., Abdelmasseh M., Abd-Elsalam S., Abdoli A., Abebe H., Abedi A., Abidi H., Abolhassani H., Abubaker Ali H., Abu-Gharbieh E., Achappa B., Acuna J.M., Adedeji I.A., Adegboye O.A., Adnani Q.E.S., Advani S.M., Afzal M.S., Aghaie Meybodi M., Ahadinezhad B., Ahinkorah B.O., Ahmad S., Ahmadi S., Ahmed M.B., Ahmed Rashid T., Ahmed Salih Y., Aiman W., Akalu G.T., Al Hamad H., Alahdab F., AlAmodi A.A., Alanezi F.M., Alanzi T.M., Alem A.Z., Alem D.T., Alemayehu Y., Alhalaiqa F.N., Alhassan R.K., Ali S., Alicandro G., Alipour V., Aljunid S.M., Alkhayyat M., Alluri S., Almasri N.A., Al-Maweri S.A., Almustanyir S., Al-Raddadi R.M., Alvis-Guzman N., Ameyaw E.K., Amini S., Amu H., Ancuceanu R., Andrei C.L., Andrei T., Ansari F., Ansari-Moghaddam A., Anvari D., Anyasodor A.E., Arabloo J., Arab-Zozani M., Argaw A.M., Arshad M., Arulappan J., Aryannejad A., Asemi Z., Asghari Jafarabadi M., Atashzar M.R., Atorkey P., Atreya A., Attia S., Aujayeb A., Ausloos M., Avila-Burgos L., Awedew A.F., Ayala Quintanilla B.P., Ayele A.D., Ayen S.S., Azab M.A., Azadnajafabad S., Azami H., Azangou-Khyavy M., Azari Jafari A., Azarian G., Azzam A.Y., Bahadory S., Bai J., Baig A.A., Baker J.L., Banach M., Barnighausen T.W., Barone-Adesi F., Barra F., Barrow A., Basaleem H., Batiha A.-M.M., Behzadifar M., Bekele N.C., Belete R., Belgaumi U.I., Bell A.W., Berhie A.Y., Bhagat D.S., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhaskar S., Bhattacharyya K., Bhojaraja V.S., Bibi S., Bijani A., Biondi A., Birara S., Bjorge T., Bolarinwa O.A., Bolla S.R., Boloor A., Braithwaite D., Brenner H., Bulamu N.B., Burkart K., Bustamante-Teixeira M.T., Butt N.S., Butt Z.A., Caetano dos Santos F.L., Cao C., Cao Y., Carreras G., Catala-Lopez F., Cembranel F., Cerin E., Chakinala R.C., Chakraborty P.A., Chattu V.K., Chaturvedi P., Chaurasia A., Chavan P.P., Chimed-Ochir O., Choi J.-Y.J., Christopher D.J., Chu D.-T., Chung M.T., Conde J., Costa V.M., Da'ar O.B., Dadras O., Dahlawi S.M.A., Dai X., Damiani G., D'Amico E., Dandona L., Dandona R., Daneshpajouhnejad P., Darwish A.H., Daryani A., De la Hoz F.P., Debela S.A., Demie T.G.G., Demissie G.D., Demissie Z.G., Denova-Gutierrez E., Derbew Molla M., Desai R., Desta A.A., Dhamnetiya D., Dharmaratne S.D., Dhimal M.L., Dhimal M., Dianatinasab M., Didehdar M., Diress M., Djalalinia S., Do H.P., Doaei S., Dorostkar F., dos Santos W.M., Drake T.M., Ekholuenetale M., El Sayed I., El Sayed Zaki M., El Tantawi M., El-Abid H., Elbahnasawy M.A., Elbarazi I., Elhabashy H.R., Elhadi M., El-Jaafary S.I., Enyew D.B., Erkhembayar R., Eshrati B., Eskandarieh S., Faisaluddin M., Fares J., Farooque U., Fasanmi A.O., Fatima W., Ferreira de Oliveira J.M.P., Ferrero S., Ferro Desideri L., Fetensa G., Filip I., Fischer F., Fisher J.L., Foroutan M., Fukumoto T., Gaal P.A., Gad M.M., Gaewkhiew P., Gallus S., Garg T., Gebremeskel T.G., Gemeda B.N.B., Getachew T., Ghafourifard M., Ghamari S.-H., Ghashghaee A., Ghassemi F., Ghith N., Gholami A., Gholizadeh Navashenaq J., Gilani S.A., Ginindza T.G., Gizaw A.T., Glasbey J.C., Goel A., Golechha M., Goleij P., Golinelli D., Gopalani S.V., Gorini G., Goudarzi H., Goulart B.N.G., Grada A., Gubari M.I.M., Guerra M.R., Guha A., Gupta B., Gupta S., Gupta V.B., Gupta V.K., Haddadi R., Hafezi-Nejad N., Hailu A., Haj-Mirzaian A., Halwani R., Hamadeh R.R., Hambisa M.T., Hameed S., Hamidi S., Haque S., Hariri S., Haro J.M., Hasaballah A.I., Hasan S.M.M., Hashemi S.M., Hassan T.S., Hassanipour S., Hay S.I., Hayat K., Hebo S.H., Heidari G., Heidari M., Herrera-Serna B.Y., Herteliu C., Heyi D.Z., Hezam K., Hole M.K., Holla R., Horita N., Hossain M.M., Hossain M.B., Hosseini M.-S., Hosseini M., Hosseinzadeh A., Hosseinzadeh M., Hostiuc M., Hostiuc S., Househ M., Hsairi M., Huang J., Hussein N.R., Hwang B.-F., Ibitoye S.E., Ilesanmi O.S., Ilic I.M., Ilic M.D., Innos K., Irham L.M., Islam R.M., Islam S.M.S., Ismail N.E., Isola G., Iwagami M., Jacob L., Jadidi-Niaragh F., Jain V., Jakovljevic M., Janghorban R., Javadi Mamaghani A., Jayaram S., Jayawardena R., Jazayeri S.B., Jebai R., Jha R.P., Joo T., Joseph N., Joukar F., Jurisson M., Kaambwa B., Kabir A., Kalankesh L.R., Kaliyadan F., Kamal Z., Kamath A., Kandel H., Kar S.S., Karaye I.M., Karimi A., Kassa B.G., Kauppila J.H., Kemp Bohan P.M., Kengne A.P., Kerbo A.A., Keykhaei M., Khader Y.S., Khajuria H., Khalili N., Khan E.A., Khan G., Khan M., Khan M.N., Khan M.A., Khanali J., Khayamzadeh M., Khosravizadeh O., Khubchandani J., Khundkar R., Kim M.S., Kim Y.J., Kisa A., Kisa S., Kissimova-Skarbek K., Kolahi A.-A., Kopec J.A., Koteeswaran R., Koulmane Laxminarayana S.L., Koyanagi A., Kugbey N., Kumar G.A., Kumar N., Kwarteng A., La Vecchia C., Lan Q., Landires I., Lasrado S., Lauriola P., Ledda C., Lee S.-W., Lee W.-C., Lee Y.Y., Lee Y.H., Leigh J., Leong E., Li B., Li J., Li M.-C., Lim S.S., Liu X., Lobo S.W., Loureiro J.A., Lugo A., Lunevicius R., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahmoudi M., Majeed A., Makki A., Male S., Malekpour M.-R., Malekzadeh R., Malik A.A., Mamun M.A., Manafi N., Mansour-Ghanaei F., Mansouri B., Mansournia M.A., Martini S., Masoumi S.Z., Matei C.N., Mathur M.R., McAlinden C., Mehrotra R., Mendoza W., Menezes R.G., Mentis A.-F.A., Meretoja T.J., Mersha A.G., Mesregah M.K., Mestrovic T., Miao Jonasson J., Miazgowski B., Michalek I.M., Miller T.R., Mingude A.B., Mirmoeeni S., Mirzaei H., Misra S., Mithra P., Mohammad K.A., Mohammadi M., Mohammadi S.M., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mohammed A., Mohammed S., Mohammed T.A., Moka N., Mokdad A.H., Molokhia M., Momtazmanesh S., Monasta L., Moni M.A., Moradi G., Moradi Y., Moradzadeh M., Moradzadeh R., Moraga P., Morrison S.D., Mostafavi E., Mousavi Khaneghah A., Mpundu-Kaambwa C., Mubarik S., Mwanri L., Nabhan A.F., Nagaraju S.P., Nagata C., Naghavi M., Naimzada M.D., Naldi L., Nangia V., Naqvi A.A., Narasimha Swamy S., Narayana A.I., Nayak B.P., Nayak V.C., Nazari J., Nduaguba S.O., Negoi I., Negru S.M., Nejadghaderi S.A., Nepal S., Neupane Kandel S., Nggada H.A., Nguyen C.T., Nnaji C.A., Nosrati H., Nouraei H., Nowroozi A., Nunez-Samudio V., Nwatah V.E., Nzoputam C.I., Oancea B., Odukoya O.O., Oguntade A.S., Oh I.-H., Olagunju A.T., Olagunju T.O., Olakunde B.O., Oluwasanu M.M., Omar E., Omar Bali A., Ong S., Onwujekwe O.E., Ortega-Altamirano D.V., Otstavnov N., Otstavnov S.S., Oumer B., Owolabi M.O., P A M., Padron-Monedero A., Padubidri J.R., Pakshir K., Pana A., Pandey A., Pardhan S., Pashazadeh Kan F., Pasovic M., Patel J.R., Pati S., Pattanshetty S.M., Paudel U., Pereira R.B., Peres M.F.P., Perianayagam A., Postma M.J., Pourjafar H., Pourshams A., Prashant A., Pulakunta T., Qadir M.M.F.F., Rabiee M., Rabiee N., Radfar A., Radhakrishnan R.A., Rafiee A., Rafiei A., Rafiei S., Rahim F., Rahimzadeh S., Rahman M., Rahman M.A., Rahmani A.M., Rajesh A., Ramezani-Doroh V., Ranabhat K., Ranasinghe P., Rao C.R., Rao S.J., Rashedi S., Rashidi M., Rashidi M.-M., Rath G.K., Rawaf D.L., Rawaf S., Rawal L., Rawassizadeh R., Razeghinia M.S., Regasa M.T., Renzaho A.M.N., Rezaei M., Rezaei N., Rezaeian M., Rezapour A., Rezazadeh-Khadem S., Riad A., Rios Lopez L.E., Rodriguez J.A.B., Ronfani L., Roshandel G., Rwegerera G.M., Saber-Ayad M.M., Sabour S., Saddik B., Sadeghi E., Sadeghian S., Saeed U., Sahebkar A., Saif-Ur-Rahman K.M., Sajadi S.M., Salahi S., Salehi S., Salem M.R., Salimzadeh H., Samy A.M., Sanabria J., Sanmarchi F., Sarveazad A., Sathian B., Sawhney M., Sawyer S.M., Saylan M., Schneider I.J.C., Seidu A.-A., Sekerija M., Sendo E.G., Sepanlou S.G., Seylani A., Seyoum K., Sha F., Shafaat O., Shaikh M.A., Shamsoddin E., Shannawaz M., Sharma R., Sheikhbahaei S., Shetty A., Shetty B.S.K., Shetty P.H., Shin J.I., Shirkoohi R., Shivakumar K.M., Shobeiri P., Siabani S., Sibhat M.M., Siddappa Malleshappa S.K., Sidemo N.B., Silva D.A.S., Silva Julian G., Singh A.D., Singh J.A., Singh J.K., Singh S., Sinke A.H., Sintayehu Y., Skryabin V.Y., Skryabina A.A., Smith L., Sofi-Mahmudi A., Soltani-Zangbar M.S., Song S., Spurlock E.E., Steiropoulos P., Straif K., Subedi R., Sufiyan M.B., Suliankatchi Abdulkader R., Sultana S., Szerencses V., Szocska M., Tabaeian S.P., Tabares-Seisdedos R., Tabary M., Tabuchi T., Tadbiri H., Taheri M., Taherkhani A., Takahashi K., Tampa M., Tan K.-K., Tat V.Y., Tavakoli A., Tbakhi A., Tehrani-Banihashemi A., Temsah M.-H., Tesfay F.H., Tesfaye B., Thakur J.S., Thapar R., Thavamani A., Thiyagarajan A., Thomas N., Tobe-Gai R., Togtmol M., Tohidast S.A., Tohidinik H.R., Tolani M.A., Tollosa D.N., Touvier M., Tovani-Palone M.R., Traini E., Tran B.X., Tran M.T.N., Tripathy J.P., Tusa B.S., Ukke G.G., Ullah I., Ullah S., Umapathi K.K., Unnikrishnan B., Upadhyay E., Ushula T.W., Vacante M., Valadan Tahbaz S., Varthya S.B., Veroux M., Villeneuve P.J., Violante F.S., Vlassov V., Vu G.T., Waheed Y., Wang N., Ward P., Weldesenbet A.B., Wen Y.F., Westerman R., Winkler A.S., Wubishet B.L., Xu S., Yahyazadeh Jabbari S.H., Yang L., Yaya S., Yazdi-Feyzabadi V., Yazie T.S., Yehualashet S.S., Yeshaneh A., Yeshaw Y., Yirdaw B.W., Yonemoto N., Younis M.Z., Yousefi Z., Yu C., Yunusa I., Zadnik V., Zahir M., Zahirian Moghadam T., Zamani M., Zamanian M., Zandian H., Zare F., Zastrozhin M.S., Zastrozhina A., Zhang J., Zhang Z.-J., Ziapour A., Zoladl M., Murray C.J.L., Fitzmaurice C., Bleyer A., Bhakta N., Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), HUS Comprehensive Cancer Center, University of Helsinki, Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St. Baldrick's Foundation, NIH - National Cancer Institute (NCI) (Estados Unidos), Epidemiologie, and RS: NUTRIM - R3 - Respiratory & Age-related Health
Subjects: adolescent cancer, global burden of disease, epidemiology, Adult, Male, Adolescent, 3122 Cancers, UNITED-STATES, Disability-Adjusted Life Year, Adolescents, Socioeconomic Factor, Global Health, Global Burden of Disease, Young Adult, Life Expectancy, SDG 3 - Good Health and Well-being, Risk Factors, WORLDWIDE, Neoplasms, Cause of Death, Prevalence, Humans, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, Mortality, Cancer burden analyses, Cancer, ACUTE LYMPHOBLASTIC-LEUKEMIA, disease, Global burden, OUTCOMES, CHILDHOOD-CANCER, Incidence, Risk Factor, the GBD 2019 methodology, Disability-Adjusted Life Years, GBD 2019 Adolescent Young Adult Cancer Collaborators, CARE, Cancer control efforts, Socioeconomic Factors, Oncology, Neoplasm, Female, Young adults, Human
Abstract: Funding: J A Loureiro acknowledges support from Base Funding UIDB/00511/2020 of the LEPABE funded by national funds through the FCT/MCTES (PIDDAC) and Scientific Employment Stimulus (FCT) [CEECINST/00049/2018]. Background: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15–39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15–39 years to define adolescents and young adults. Findings: There were 1·19 million (95% UI 1·11–1·28) incident cancer cases and 396 000 (370 000–425 000) deaths due to cancer among people aged 15–39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5–65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8–57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9–15·6] per 100 000 person-years) and middle SDI (13·6 [12·6–14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9–25·2) DALYs to the global burden of disease, of which 2·7% (1·9–3·6) came from YLDs and 97·3% (96·4–98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation: Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Funding: Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute. publishersversion published
Published: 2022

64. Actividades de trabajo y lumbalgia crónica inespecífica en trabajadores de enfermería

Author: Dulcinéia Ghizoni Schneider, Zulamar Aguiar Cargnin, Mara Ambrosina de Oliveira Vargas, and Ione Jayce Ceola Schneider
Subjects: Advanced and Specialized Nursing, 030506 rehabilitation, Pain measurement, Medição da dor, Profissionais de enfermagem, RT1-120, Nursing, Dolor de la región lumbar, Enfermeras practicantes, 03 medical and health sciences, Medical–Surgical Nursing, 0302 clinical medicine, Nurse practitioners, Low back pain, 030212 general & internal medicine, Ergonomics, Dor lombar, Ergonomía, 0305 other medical science, Dimensión del dolor, Ergonomia
Abstract: Resumo Objetivo: Determinar as atividades laborais associadas à dor lombar crônica inespecífica em trabalhadores de enfermagem. Métodos: Estudo transversal com 90 trabalhadores entre auxiliares, técnicos e enfermeiros. Dois instrumentos foram utilizados: o Work-Related Activities that may Contribute to Job-Related Pain and/or injury e Escala Visual Numérica. Os dados foram analisados de forma descritiva e analítica, comparados por meio dos testes Qui-quadrado ou exato de Fischer, correlações de Pearson ou de Spearman e o Teste U de Mann-Whitney. O nível de significância adotado foi p0,05. Resultados: Las actividades laborales con mayor puntuación de riesgo y asociadas al dolor lumbar incluyeron posturas inadecuadas con flexión y torsión de la columna y posiciones incómodas, esfuerzos físicos, como carga y movimiento de peso, condición física de continuar trabajando con dolor y al límite físico, relacionadas con las características del ambiente de trabajo y el tipo de tarea. El nivel promedio de intensidad del dolor fue moderado y con asociación estadísticamente significativa con algunas actividades. Conclusión: Se debe prestar atención a las actividades ergonómicas que predisponen episodios de dolor lumbar para orientar cambios en los puestos de trabajo. Abstract Objective: To determine work activities associated with non-specific chronic low back pain in nursing workers. Métodos: Cross-sectional study with 90 workers, including nursing assistants, nursing technicians and nurses. Two instruments were used: Work-Related Activities that may Contribute to Job-Related Pain and/or Injury and Visual Numeric Scale. Data were descriptively and analytically analyzed, compared using Chi-square or Fischer's exact tests, Pearson's or Spearman's correlations and the Mann-Whitney U test. The significance level adopted was p
Published: 2019

65. Rehabilitation in Survivors of COVID-19 (RE2SCUE): a nonrandomized, controlled, and open protocol

Author: Ana Elisa Speck, Maria Paula Pereira Matos, Ione Jayce Ceola Schneider, Tatyana Nery, Ana Cristina de Bem Alves, Danielle Soares Rocha Vieira, Maria Cristine Campos, Livia Arcêncio, and Aderbal S. Aguiar
Subjects: medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, Consolidated Standards of Reporting Trials, law.invention, Treatment and control groups, Randomized controlled trial, law, Joint pain, medicine, Physical therapy, Heart rate variability, Anxiety, medicine.symptom, business, Depression (differential diagnoses)
Abstract: ObjectiveThis study aimed to evaluate the effects of physical rehabilitation for adults with sequelae after COVID-19.MethodsThis clinical, nonrandomized, controlled, and open study will examine 82 participants who have met the inclusion criteria and who will be divided into treatment and control groups according to participant preference. The intervention group will receive face-to-face care; the control group will receive remote educational guidance for 8 weeks, with pre-post evaluations. The primary outcomes are dyspnea, fatigue, and exercise capacity; the secondary outcomes are lung function, heart rate variability, handgrip strength, knee extensor strength and electrical activity, physical activity, functional limitation, cognitive function, depression and anxiety, and biochemical measures of hypoxia, inflammation, oxidative stress, blood glucose, and lactate blood tests. The survey will follow theStandard Protocol Items for Randomized Trialsguidelines, and the results will be reported according to theConsolidated Standards of Reporting Trialsguidelines. Effects will be assessed based on the intent-to-treat data collected. Analysis of covariance will be used for the initial and final evaluations, with a significance level of 5%.Results and ConclusionsThe results will show the effectiveness of rehabilitation in adults with post-COVID-19 sequelae.ImpactFatigue, dyspnea, cough, and muscle and joint pain are common sequelae of post-COVID-19 syndrome. Physical rehabilitation is one modality for treating these sequelae. This protocol can provide a treatment model for patients with post-COVID-19 sequelae.
Published: 2021

66. Survival and burden of cancer: A population-based analysis in a medium size city in Brazil

Author: Tauana Prestes Schmidt, Eliane Traebert, Ione Jayce Ceola Schneider, Leandro Pereira Garcia, Rodrigo Dias Nunes, Jefferson Traebert, Paula Stefânia da Mota de Souza Patrício, and Rafael Aiello Bomfim
Subjects: Oncology, medicine.medical_specialty, Survival, Epidemiology, Rectum, Carga de doença, Sobrevivência, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Incidência, Epidemiología, 030212 general & internal medicine, Mortality, Epidemiologia, Disease burden, General Environmental Science, Cancer, Public health, business.industry, Incidence (epidemiology), Incidence, Thyroid, Saúde pública, medicine.disease, medicine.anatomical_structure, Years of potential life lost, 030220 oncology & carcinogenesis, Mortalidade, General Earth and Planetary Sciences, Câncer, business, Cohort study
Abstract: Objective: The aim of this study was to estimate 5-year survival and the burden of cancer in a medium-sized city in Southern Brazil. Methods: A cohort study was performed using governmental data of incidence and mortality from cancer at Florianopolis/SC, Southern Brazil. Survival rates were performed using Kaplan Meier methods and log-rank test to compare curves. Disability-adjusted life years (DALY), years lived with disability (YLD) and years of life lost (YLL) and age-standardized rates of each indicator were estimated. Results: Thyroid, prostate and melanoma of skin had higher survival rates. Cancers presenting the highest burden, in decreasing order, were thyroid, prostate, breast, trachea, bronchus and lung, followed by colon and rectum. Conclusion: The estimates in local level could be help the health services to improve their quality. Highest burden was related to thyroid, prostate and breast due to the highest survival rates. Other cancer as trachea, bronchus and lung, and colon and rectum had high burden due to mortality. Objetivo: Estimar a sobrevida em cinco anos e a carga de câncer em uma cidade de médio porte no sul do Brasil. Métodos: Foi realizado um estudo de coorte utilizando datos de gobierno de incidência e mortalidade por cáncer en Florianópolis/SC, Sul do Brasil. As taxas de sobrevivência forram used using os métodos Kaplan Meier e teste de log-rank para comparar as curvas. Anos de vida ajustados por incapacidade (DALY), anos vividos com incapacidade (YLD) e anos de vida perdidos (YLL) e taxas padronizadas por idade de cada indicador foram estimadas. Resultados: Tireoide, próstata e melanoma da pele tiveram maiores taxas de sobrevivência. Os cânceres que apresentaram maior carga, em ordem decrescente, foram tireoide, próstata, mama, traqueia, brônquios e pulmão, seguidos por cólon e reto. Conclusión: Como estimativas em nível local podem ajudar os serviços de saúde a melhorar sua qualidade. A maior carga foi relacionada à tireoide, próstata e mama devido às maiores taxas de sobrevivência. Outros tipos de câncer, como traqueia, brônquios e pulmões, e cólon e reto, apresentaram alta carga devido à mortalidade. Objetivo: Estimar a sobrevida em cinco anos e a carga de câncer em uma cidade de médio porte no sul do Brasil. Métodos: Foi realizado um estudo de coorte utilizando dados governamentais de incidência e mortalidade por câncer em Florianópolis/SC, Sul do Brasil. As taxas de sobrevivência foram realizadas usando os métodos Kaplan Meier e teste de log-rank para comparar as curvas. Anos de vida ajustados por incapacidade (DALY), anos vividos com incapacidade (YLD) e anos de vida perdidos (YLL) e taxas padronizadas por idade de cada indicador foram estimadas. Resultados: Tireoide, próstata e melanoma da pele tiveram maiores taxas de sobrevivência. Os cânceres que apresentaram maior carga, em ordem decrescente, foram tireoide, próstata, mama, traqueia, brônquios e pulmão, seguidos por cólon e reto. Conclusão: As estimativas em nível local podem ajudar os serviços de saúde a melhorar sua qualidade. A maior carga foi relacionada à tireoide, próstata e mama devido às maiores taxas de sobrevivência. Outros tipos de câncer, como traqueia, brônquios e pulmões, e cólon e reto, apresentaram alta carga devido à mortalidade.
Published: 2021

67. Câncer de Próstata: análise de sobrevida e fatores prognósticos por faixa etária de diagnóstico

Author: Heloísa Nunes Zardeto, Tauana Prestes Schmidt, and Ione Jayce Ceola Schneider
Subjects: General Earth and Planetary Sciences, General Environmental Science
Abstract: Objetivo: Analisar a probabilidade de sobrevida e fatores prognósticos após cinco anos do diagnóstico de câncer de próstata em Florianópolis (SC). Métodos: Trata-se de um estudo de coorte com dados do Registro de Câncer de Base Populacional (2008-2012), e do Sistema de Informação sobre Mortalidade (2008-2017). O tempo de sobrevida foi o intervalo entre a data do diagnóstico e a data do óbito ou final do acompanhamento. As variáveis independentes foram idade, etnia, grau de instrução, estado civil e extensão da doença. As análises foram estratificadas por faixa etária. Resultados: Foram incluídos 836 homens e 103 foram a óbito por câncer durante o acompanhamento. A probabilidade de sobrevida encontrada foi de 87,7%. O aumento da idade reduziu a sobrevida, enquanto a extensão metastática foi o fator independente para o óbito. Conclusão: A idade e o estadiamento avançado são determinantes para o prognóstico do paciente com essa neoplasia. Ressalta-se a importância em reduzir o tempo entre manifestação de sintomas e diagnóstico do câncer.
Published: 2022

68. Tendência dos anos de vida perdidos ajustados por incapacidade em pessoas com câncer de pulmão em Florianópolis no período de 2008 a 2012

Author: Paula Stefânia da Mota de Souza Patrício, Tauana Prestes Schmidt, Vanessa Pereira Corrêa, Camila Thais Adam, and Ione Jayce Ceola Schneider
Subjects: General Earth and Planetary Sciences, General Environmental Science
Abstract: Introdução: Os anos de vida perdidos ajustados por incapacidade (DALY), conhecido como carga de doença, mensuram o impacto de uma doença na população. O câncer de pulmão está entre as principais causas de carga de doença no mundo. Objetivo: Analisar a tendência dos anos de vida perdidos ajustados por incapacidade em pessoas com diagnóstico de câncer de pulmão em Florianópolis, no período de 2008 a 2012. Métodos: Foi realizado um estudo ecológico com dados do Sistema de Informações sobre Mortalidade para estimar os Anos de Vida Perdidos (YLL) e do Registro de Câncer de Base Populacional de Florianópolis para os Anos Vividos com Incapacidade (YLD), e a soma destes, gerou o DALY. Foram calculadas as taxas ajustadas geral, por sexo e faixas etárias. As tendências foram estimadas pelo programa Joinpoint. Resultados: Estimou-se 8.791,17 DALYs, 98,2% relacionados ao YLL. Os indicadores apresentaram estabilidade durante o período. O sexo masculino representou 58,1% da carga. Conclusão: A tendência da carga do câncer de pulmão apresentou estabilidade. Entretanto as faixas etárias de 50 a 69 anos tiveram maiores taxas. Isto reforça a importância da redução do tabagismo na população de Florianópolis, para redução da carga estimada.
Published: 2022

69. Neoplasias relacionadas ao tabaco: análise de sobrevivência e risco de óbito de dados populacionais de Florianópolis, SC

Author: Ione Jayce Ceola Schneider, Tauana Prestes Schmidt, Vanessa Pereira Correa, Ana Maria Martins dos Santos, Bruna Vanti da Rocha, Leandro Pereira Garcia, and Roger Flores Ceccon
Subjects: Public Health, Environmental and Occupational Health
Abstract: OBJETIVO Estimar a probabilidade de sobrevivência e os fatores prognósticos das neoplasias relacionados ao tabagismo em uma coorte de base populacional. MÉTODOS Trata-se de uma coorte com dados do Registro de Câncer de Base Populacional de Florianópolis, região Sul do Brasil, de 2008 a 2012. Utilizou-se o software Stata 16.0 para estimar as probabilidades de sobrevivência em cinco anos após o diagnóstico, pelo método de Kaplan Meier, e os riscos de óbito, pela regressão de Cox. RESULTADOS Foram incluídos 2.829 registros de câncer relacionados ao tabagismo, mais prevalentes entre pessoas do sexo masculino, com mais de 70 anos, nove anos ou mais de escolaridade, cor branca, com companheiro e diagnóstico metastático. Os agrupamentos mais frequentes foram cólon e reto (28,7%), traqueia, brônquios e pulmões (18,6%) e estômago (11,8%). No acompanhamento, 1.450 foram a óbito. O câncer de pâncreas foi o que apresentou pior probabilidade de sobrevivência (14,3%), seguido pelo câncer de fígado (19,4%). CONCLUSÃO Os fatores de risco para o óbito e as taxas de sobrevivência diferem entre os 13 tipos de câncer relacionados ao tabaco. O diagnóstico precoce e a prevenção primária são estratégias que devem ser aprimoradas para melhorar a sobrevivência e diminuir a carga relacionada a esses tipos de câncer.
Published: 2022

70. Tobacco-related neoplasms: survival analysis and risk of death of population data from Florianópolis, SC

Author: Ione Jayce Ceola, Schneider, Tauana Prestes, Schmidt, Vanessa Pereira, Correa, Ana Maria Martins Dos, Santos, Bruna Vanti da, Rocha, Leandro Pereira, Garcia, and Roger Flores, Ceccon
Subjects: Aged, 80 and over, Male, Pancreatic Neoplasms, Survival Rate, Neoplasms, Tobacco, Humans, Female, Kaplan-Meier Estimate, Survival Analysis, Brazil, Aged
Abstract: To estimate the probability of survival and prognostic factors for tobacco-related neoplasms in a population-based cohort.This is a cohort with data from the Population-Based Cancer Registry of Florianópolis, southern Brazil, from 2008 to 2012. The Stata 16.0 software was used to estimate the probabilities of survival in five years after diagnosis, by the Kaplan Meier method, and the risk of death, by the Cox regression.A total of 2,829 cancer records related to smoking were included, more prevalent among males, over 70 years of age, nine years or more of schooling, white, with a partner and metastatic diagnosis. The most frequent groupings were colon and rectum (28.7%), trachea, bronchi and lungs (18.6%) and stomach (11.8%). At follow-up, 1,450 died. Pancreatic cancer had the worst probability of survival (14.3%), followed by liver cancer (19.4%).Risk factors for death and survival rates differ across the 13 types of tobacco-related cancers. Early diagnosis and primary prevention are strategies that must be improved to improve survival and decrease the burden related to these types of cancer.
Published: 2021

71. Complete Tooth Loss and Allostatic Load Changes Later in Life: A 12-Year Follow-Up Analysis of the English Longitudinal Study of Ageing

Author: Cesar de Oliveira, Ione Jayce Ceola Schneider, Wael Sabbah, and Eduardo Bernabé
Subjects: Adult, Male, Longitudinal study, Aging, Waist, CI = confidence interval, 03 medical and health sciences, chemistry.chemical_compound, Tooth Loss, ELSA = English Longitudinal Study of Ageing, 0302 clinical medicine, AL = allostatic load, Tooth loss, Medicine, Humans, Longitudinal Studies, Applied Psychology, business.industry, Confounding, biomarkers, Original Articles, Allostatic load, Confidence interval, 030227 psychiatry, Psychiatry and Mental health, Cross-Sectional Studies, chemistry, Allostasis, LME = linear mixed effects, Cohort, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, fruit and vegetable consumption, Female, Glycated hemoglobin, medicine.symptom, business, SD = standard deviation, metabolism, 030217 neurology & neurosurgery, allostatic load, Demography, Follow-Up Studies
Abstract: Supplemental digital content is available in the text., Objective There is little evidence of the association between complete tooth loss and allostatic load (AL). We investigated, firstly, the association between complete tooth loss and changes in AL for 12 years among older English adults. A second aim was to explore the role of fruit and vegetable consumption in explaining the aforementioned association. Methods AL was calculated for 2430 English Longitudinal Study of Ageing cohort (2004/5–2016/17) participants 50 years and older based on nine biomarkers: systolic and diastolic blood pressures, glycated hemoglobin, high- and low-density lipoprotein cholesterol, triglycerides, fibrinogen, C-reactive protein, and waist circumference. The exposure was complete tooth loss. Participants were classified as dentate or edentulous. A linear mixed-effects model was fitted to model the 12-year change in AL score and its association with complete tooth loss after adjustments for confounders (demographic factors, socioeconomic position, and health behaviors). Results Around 11% of the participants were edentulous. Complete tooth loss was positively associated with baseline AL scores but not with its rate of change over time. The predicted mean AL scores were 3.60 (95% confidence interval [CI] = 3.53–3.68) and 3.98 (95% CI = 3.76–4.21) as well as 4·28 (95% CI = 4·18, 4·39) and 4·66 (95% CI = 4·42, 4·90) for dentate and edentulous participants, at baseline and end of follow-up, respectively. Fruit and vegetable consumption was not associated with baseline AL or its rate of change. Conclusions Complete tooth loss was associated with baseline AL score but not with its development over time, whereas the consumption of fruit and vegetables did not help to explain this association. Both conditions may share common determinants earlier in life.
Published: 2021

72. PREVALENCIA Y FACTORES ASOCIADOS A LA LUMBALGIA NO ESPECÍFICA EN TRABAJADORES DE ENFERMERÍA

Author: Dulcinéia Ghizoni Schneider, Zulamar Aguiar Cargnin, and Ione Jayce Ceola Schneider
Subjects: Activities of daily living, Multivariate analysis, Nursing, Professional diseases, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, medicine, Prevalence, Low back pain, Prevalência, 030212 general & internal medicine, General Nursing, Doenças profissionais, 030504 nursing, Fatores de risco, business.industry, Enfermagem, Odds ratio, Confidence interval, Risk factors, Lumbalgia, Public hospital, Enfermería, Dor lombar, medicine.symptom, 0305 other medical science, business, Prevalencia, Psychosocial, Enfermedades profesionales, Factores de riesgo
Abstract: Objective: to determine the prevalence and factors associated with nonspecific low back pain in nursing workers in a public hospital in the South of the country. Method: a cross-sectional study involving 301 nursing workers. Data collection was carried out from May to October 2017 and, in addition to a questionnaire with sociodemographic, work, health conditions, lifestyle and psychosocial conditions, the Nordic Musculoskeletal Questionnaire was used as a screening tool for low back pain and the Self Report Questionnaire to assess the possibility of minor psychiatric disorders. The Chi-Square test was used to analyze the association between variables, and multivariate analysis with Binary Logistic Regression to estimate the Odds Ratio and the 95% confidence intervals. Results: the prevalence of nonspecific low back pain was 51.4% (95% CI: 45.5-57.3) in the last 12 months and 45.4% (95% CI: 39.4-51.3) in the last seven days, and limitation for activities of daily living and work of 18.1% (95% CI: 13.5-22.7). The presence of other diseases and psychosocial and psychological factors increased the chances of presenting or low back pain discomfort. Conclusion: the results demonstrate the need for greater attention to nursing workers, mainly related to the presence of musculoskeletal pain and to their mental suffering. RESUMEN Objetivo: determinar la prevalencia y los factores asociados a la lumbalgia no específica en trabajadores de Enfermería de un hospital público del sur del país. Método: estudio transversal en el que participaron 301 trabajadores de Enfermería. La recolección de datos se realizó entre mayo y octubre de 2017 y, además de un cuestionario con datos sociodemográficos, laborales, afecciones de salud, estilo de vida y condiciones psicosociales, se aplicó el Nordic Musculoskeletal Questionnaire como instrumento de rastreo para la lumbalgia y el Self Report Questionnaire para evaluar la posibilidad de trastornos psíquicos menores. Se utilizó la prueba de Chi-Cuadrado para analizar la asociación entre las variables y análisis multivariado con Regresión Logística Binaria para estimar el Odds Ratio y los intervalos de confianza del 95%. Resultados: la prevalencia de la lumbalgia no específica fue del 51,4% (IC95%: 45,5-57,3) en los últimos 12 meses y del 45,4% (IC95%: 39,4-51,3) en los últimos siete días, además de limitación en actividades de la vida diaria e de trabajo del 18,1% (IC95%: 13,5-22,7). La presencia de otras enfermedades y de otros factores psicosociales y psicológicos aumentaron las probabilidades de presentar dolor o malestar lumbar. Conclusión: los resultados demuestran que es necesario prestar mayor atención a los trabajadores de Enfermería, principalmente en relación con la presencia de dolores musculoesqueléticos y con el sufrimiento mental. RESUMO Objetivo: determinar a prevalência e fatores associados à dor lombar inespecífica em trabalhadores de enfermagem em um hospital público do sul do país. Método: estudo transversal envolvendo 301 trabalhadores de enfermagem. A coleta de dados foi realizada no período de maio a outubro de 2017 e foram aplicados, além de um questionário com dados sociodemográficos, laborais, condições de saúde, estilo de vida e condições psicossociais, o Nordic Musculoskeletal Questionnaire como instrumento de rastreio para dor lombar e o Self Report Questionnaire para avaliação da possibilidade de distúrbios psíquicos menores. Utilizou-se o teste Qui-Quadrado para analisar a associação entre as variáveis e análise multivariável com Regressão Logística Binária para estimar o Odds Ratio e os intervalos de confiança de 95%. Resultados: a prevalência de dor lombar inespecífica foi de 51,4% (IC95%: 45,5-57,3) nos últimos 12 meses e 45,4% (IC95%: 39,4-51,3) nos últimos sete dias e limitação para atividades de vida diária e de trabalho de 18,1% (IC95%: 13,5-22,7). A presença de outras doenças e fatores psicossociais e psicológicos aumentaram as chances de apresentar dor ou desconforto lombar. Conclusão: os resultados demonstram a necessidade de maior atenção aos trabalhadores de enfermagem, principalmente relacionada à presença de dores musculoesqueléticas e ao seu sofrimento mental.
Published: 2021

73. Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems

Author: Simachew Animen Bante, Carlo Eduardo Medina-Solís, Rodrigo Sarmiento-Suárez, Deniz Yuce, Ninuk Hariyani, Virginia Núñez-Samudio, Zhi-Jiang Zhang, Lucas Guimarães Abreu, Sindhura Lakshmi Koulmane Laxminarayana, Ejaz Ahmad Khan, Natalie Maria Cormier, Ghulam Mustafa, Arielle Wilder Eagan, Shirin Djalalinia, Jalal Arabloo, Bay Vo, Mukhammad David Naimzada, Farahnaz Joukar, Arvin Haj-Mirzaian, Julia Moreira Pescarini, Getinet Kassahun, Robert Ancuceanu, Mohammad Ali Mansournia, Amin Soheili, Félix Carvalho, Edgar Denova-Gutiérrez, Aubrey J. Cook, Jasvinder A. Singh, Maysaa El Sayed Zaki, Sergio I. Prada, Seyedeh Zahra Masoumi, Rajesh Sagar, Emmanuel Peprah, Fenta Hun Y. Beyene, Mikhail Sergeevich Zastrozhin, Dimas Ria Angga Pribadi, Yun Jin Kim, Maryam Adabi, Feleke Mekonnen Demeke, Valentin Yurievich Skryabin, Mathew M. Baumann, Bárbara Niegia Garcia de Goulart, Ali Kazemi Karyani, Nooshin Abbasi, Eyayou Girma Tadesse, Sanjay Basu, Hadi Hassankhani, Keyghobad Ghadiri, Keshab Deuba, Dilshad Manzar, Robert L. Thompson, Keivan Ahmadi, Rahmatollah Moradzadeh, Shaimaa I. El-Jaafary, Alessandra C. Goulart, Diana Fernanda Bejarano Ramirez, Samata Nepal, Marcos Roberto Tovani-Palone, Gebiyaw Wudie Tsegaye, Irina Filip, Ian D. Letourneau, Ramesh Holla, Neda Kianipour, Maha El Tantawi, Lucas Earl, Paul S. F. Yip, Miguel A Barboza, Rajan Nikbakhsh, Nauman Khalid, Kimberly B. Johnson, Iván Landires, Manasi Kumar, Babak Moazen, Rohol Lah Kalhor, Dinh-Toi Chu, Lauren E. Schaeffer, Nima Rezaei, Alexandre C. Pereira, Susan F. Rumisha, Mehdi Hosseinzadeh, Xuefeng Liu, Feng Sha, Mahaveer Golechha, Davood Anvari, Urvish K Patel, Bing-Fang Hwang, Samath D Dharmaratne, Muhammad Aqeel, Kebede Deribe, Nelsensius Klau Fauk, Lillian Mwanri, Nuruzzaman Khan, Yunquan Zhang, Paula Moraga, Ai Koyanagi, Abdallah M. Samy, Nithin Kumar, Rahul Gupta, Samad Azari, Soheil Hassanipour, Archith Boloor, Kiana Ramezanzadeh, Andrew J. Croneberger, Enrico Rubagotti, Jaykaran Charan, Khezar Hayat, Amir Masoud Rahmani, Kio Mars Sharafi, Ionut Negoi, Simon I. Hay, Deborah Carvalho Malta, Yasser Vasseghian, Yihienew M. Bezabih, Jean Jacques Noubiap, Nazir Fattahi, Adnan Kisa, Alok Atreya, Devasahayam J. Christopher, Ayenew Kassie Tesema, Nuwan Darshana Wickramasinghe, Jaffar Abbas, Daniel Diaz, Desta Debalkie Atnafu, Malke Asaad, Arief Hargono, Zahid A Butt, Dharmesh Kumar Lal, Pankaj Bhardwaj, Amir Radfar, Salman Rawaf, Vardhmaan Jain, Amir Almasi-Hashiani, Krittika Bhattacharyya, João Mauricio Castaldelli-Maia, Behzad Karami Matin, Mohammad Rifat Haider, Emily Haeuser, S. Mohammad Sajadi, Francisco Rogerlândio Martins-Melo, Jagadish Rao Padubidri, Carlos Alberto Marrugo Arnedo, Beatriz Paulina Ayala Quintanilla, Tomislav Mestrovic, Hawraz Ibrahim M. Amin, Bhaskaran Unnikrishnan, Seithikurippu R. Pandi-Perumal, Arash Ziapour, Samantha Perkins, Deepa Jahagirdar, Akshaya Srikanth Bhagavathula, Eduarda Fernandes, Nataliya Foigt, Audrey L. Serfes, Fissaha Tekulu Welay, Savita Lasrado, Saad M.A. Dahlawi, Segun Emmanuel Ibitoye, Hedayat Abbastabar, Om P Kurmi, Hung Chak Ho, Faheem Hyder Pottoo, Priya Rathi, Chukwuma David Umeokonkwo, Ali Bijani, Shanshan Li, Reza Rawassizadeh, Vishnu Renjith, Barthelemy Kuate Defo, Giang Thu Vu, Farah Daoud, Tudorel Andrei, Ricardo de Souza Kuchenbecker, Fakher Rahim, Adeyinka Emmanuel Adegbosin, Sezer Kisa, Rajesh Elayedath, Shafiu Mohammed, Vinod C. Nayak, Fisaha Haile Tesfay, Cuong Tat Nguyen, Masoud Foroutan, Mingyou Yang, Yousef Mohammad, Abdul-Aziz Seidu, Benjamin K. Mayala, Diego Augusto Santos Silva, Amin Mousavi Khaneghah, Nikha Bhardwaj, Masoud Moradi, Charles Ugochukwu Ibeneme, Olatunji O. Adetokunboh, Carlo La Vecchia, Tesfay B.B. Gebremariam, Ritesh G. Menezes, Olatunde Aremu, Bogdan Oancea, Mohiuddin Ahsanul Kabir Chowdhury, Stefanie Watson, Yousef Moradi, Souranshu Chatterjee, Ugo Gori, Isabela M. Benseñor, Khem Narayan Pokhrel, Hailay Abrha Gesesew, Paul Ward, Carlos A Castañeda-Orjuela, Usman Iqbal, Rekha Thapar, Naser Mohammad Gholi Mezerji, Yasir Waheed, Ziad A. Memish, Vijay Kumar Chattu, Daiane Borges Machado, Shrikant Pawar, Soosanna Kumary Chattu, Sanni Yaya, Ketema Bizuwork Gebremedhin, Naohiro Yonemoto, Ahmad Ghashghaee, Marcela Agudelo-Botero, Amber Sligar, Nicole Davis Weaver, Kenji Shibuya, Claudiu Herteliu, Andreea Mirica, André Karch, Asif Hanif, Atif Amin Baig, Salah Eddin Karimi, Gulfaraz Khan, David Laith Rawaf, Andrew T Olagunju, Chuanhua Yu, Darshan B B, Olayinka Stephen Ilesanmi, Takeshi Fukumoto, Neeraj Bedi, Claudio Alberto Dávila-Cervantes, Muktar Beshir Ahmed, Deepak Madi, Ione Jayce Ceola Schneider, Masood Ali Shaikh, Juwel Rana, Tanuj Kanchan, Mohamed M. Gad, Syed Amir Gilani, Victor Adekanmbi, Mu'awiyyah Babale Sufiyan, Harish Chander Gugnani, Tadele G. Adal, Mohammad Hifz Ur Rahman, Leila R Kalankesh, Gbenga A. Kayode, Bach Xuan Tran, Ana Isabel Ribeiro, Basavaprabhu Achappa, Andem Effiong, André Faro, Javad Nazari, Abdollah Mohammadian-Hafshejani, Soewarta Kosen, Vahid Alipour, Sowmya J. Rao, Rosario Cárdenas, Milena Ilic, Ravi Prakash Jha, Zebenay Workneh Bitew, Nelson Alvis-Guzman, Dian Kusuma, Yum Ing Guo, Mowafa Househ, Arya Haj-Mirzaian, Krista M. Steuben, Hadush Negash, Ahamarshan Jayaraman Nagarajan, Irena Ilic, Laura Dwyer-Lindgren, Godfrey Mutashambara Rwegerera, Florian Fischer, Gebreamlak Gebremedhn Gebremeskel, Kate E. LeGrand, Ravishankar Nagaraja, Reza Mohammadpourhodki, Mark Drew Crosland Guimarães, Kewal Krishan, Maryam Zamanian, Paul H. Lee, Emerito Jose A. Faraon, Rafael Alves Guimarães, Aziz Sheikh, Marwa Rashad Salem, Michael A. Cork, Francesco Saverio Violante, Bright Opoku Ahinkorah, Liliana Preotescu, Somayeh Bohlouli, Aziz Rezapour, Ana Melisa Pardo-Montaño, Huong Lan Thi Nguyen, Khaled Khatab, Teklehaimanot Gereziher Haile, Mohammad Ali Moni, Govinda Prasad Dhungana, Leonardo Roever, Carlos Magis-Rodriguez, Andre R. Brunoni, Nathaniel J. Henry, Brijesh Sathian, Bingyu Li, Maciej Banach, Hasan Yusefzadeh, Nikita Otstavnov, Bruno Ramos Nascimento, Fernando de la Hoz, Georges Nguefack-Tsague, Zulfiqar A Bhutta, Robert Kaba Alhassan, Jae Il Shin, Andre Rodrigues Duraes, Yuan-Pang Wang, Felix Akpojene Ogbo, Mihajlo Jakovljevic, Eman Abu-Gharbieh, Vaman Kulkarni, Anna Aleksandrovna Skryabina, Sait Mentes Birlik, Maarten J. Postma, Chhabi Lal Ranabhat, Walter Mendoza, Yanzhong Wang, Maryam Keramati, Mahesh P A, Ali H. Mokdad, Muhammad Naveed, Nitin Joseph, Ronny Westerman, Bill & Melinda Gates Foundation, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), Cork M.A., Henry N.J., Watson S., Croneberger A.J., Baumann M., Letourneau I.D., Yang M., Serfes A.L., Abbas J., Abbasi N., Abbastabar H., Abreu L.G., Abu-Gharbieh E., Achappa B., Adabi M., Adal T.G., Adegbosin A.E., Adekanmbi V., Adetokunboh O.O., Agudelo-Botero M., Ahinkorah B.O., Ahmadi K., Ahmed M.B., Alhassan R.K., Alipour V., Almasi-Hashiani A., Alvis-Guzman N., Ancuceanu R., Andrei T., Anvari D., Aqeel M., Arabloo J., Aremu O., Asaad M., Atnafu D.D., Atreya A., Quintanilla B.P.A., Azari S., B D.B., Baig A.A., Banach M., Bante S.A., Barboza M.A., Basu S., Bedi N., Ramirez D.F.B., Bensenor I.M., Beyene F.-H.Y., Bezabih Y.M., Bhagavathula A.S., Bhardwaj N., Bhardwaj P., Bhattacharyya K., Bhutta Z.A., Bijani A., Birlik S.M., Bitew Z.W., Bohlouli S., Boloor A., Brunoni A.R., Butt Z.A., Cardenas R., Carvalho F., Castaldelli-Maia J.M., Casta-neda-orjuela C.A., Charan J., Chatterjee S., Chattu V.K., Chattu S.K., Chowdhury M.A.K., Christopher D.J., Chu D.-T., Cook A.J., Cormier N.M., Dahlawi S.M.A., Daoud F., Davila-Cervantes C.A., Weaver N.D., De la Hoz F.P., Demeke F.M., Denova-Gutierrez E., Deribe K., Deuba K., Dharmaratne S.D., Dhungana G.P., Diaz D., Djalalinia S., Duraes A.R., Eagan A.W., Earl L., Effiong A., Zaki M.E.S., Tantawi M.E., Elayedath R., El-Jaafary S.I., Faraon E.J.A., Faro A., Fattahi N., Fauk N.K., Fernandes E., Filip I., Fischer F., Foigt N.A., Foroutan M., Fukumoto T., Gad M.M., Gebremariam T.B.B., Gebremed-Hin K.B., Gebremeskel G.G., Gesesew H.A., Ghadiri K., Ghashghaee A., Gilani S.A., Golechha M., Gori U., Goulart A.C., Goulart B.N.G., Gugnani H.C., Guimaraes M.D.C., Guimaraes R.A., Guo Y.-I., Gupta R., Haeuser E., Haider M.R., Haile T.G., Haj-Mirzaian A., Hanif A., Hargono A., Hariyani N., Hassanipour S., Hassankhani H., Hayat K., Herteliu C., Ho H.C., Holla R., Hosseinzadeh M., Househ M., Hwang B.-F., Ibeneme C.U., Ibitoye S.E., Ile-Sanmi O.S., Ilic M.D., Ilic I.M., Iqbal U., Jahagir-Dar D., Jain V., Jakovljevic M., Jha R.P., Johnson K.B., Joseph N., Joukar F., Kalankesh L.R., Kalhor R.-L., Kanchan T., Matin B.K., Karch A., Karimi S.E., Kassahun G., Kayode G.A., Karyani A.K., Keramati M., Khalid N., Khan E.A., Khan G., Khan M.N.N., Khatab K., Kianipour N., Kim Y.J., Kisa S., Kisa A., Kosen S., Laxminarayana S.L.K., Koyanagi A., Krishan K., Defo B.K., Kuchenbecker R.S., Kulkarni V., Kumar N., Kumar M., Kurmi O.P., Kusuma D., Vecchia C.L., Lal D.K., Landires I., Lasrado S., Lee P.H., Legrand K.E., Li B., Li S., Liu X., Amin H.I.M., Machado D.B., Madi D., Magis-Rodriguez C., Malta D.C., Mansournia M.A., Manzar M.D., Arnedo C.A.M., Martins-Melo F.R., Masoumi S.Z., Mayala B.K., Medina-Solis C.E., Memish Z.A., Mendoza W., Menezes R.G., Mestrovic T., Mirica A., Moazen B., Mohammad Y., Mezerji N.M.G., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mohammed S., Mokdad A.H., Moni M.A., Moradi M., Moradi Y., Moradzadeh R., Moraga P., Khaneghah A.M.-S., Mustafa G., Mwanri L., Nagaraja R., Nagarajan A.J., Naim-Zada M.D., Nascimento B.R., Naveed D.M., Nayak V.C., Nazari J., Negash H., Negoi I., Nepal S., Nguefack-Tsague G., Nguyen C.T., Nguyen H.L.T., Nikbakhsh R., Noubiap J.J., Nunez-Samudio V., Oancea B., Ogbo F.A., Olagunju A.T., Otstav-Nov N., A M.P., Padubidri J.R., Pandi-Perumal S.R., Pardo-Montano A.M., Patel U.K., Pawar S., Peprah E.K., Pereira A., Perkins S., Pescarini J.M., Pokhrel K.N., Postma M.J., Pot-Too F.H., Prada S.I., Preotescu L., Pribadi D.R.A., Radfar A., Rahim F., Rahman M.H.U., Rahmani A.M., Ramezanzadeh K., Rana J., Ranabhat C.L., Rao S.J., Rathi P., Rawaf S., Rawaf D.L., Rawassizadeh R., Renjith V., Rezaei N., Rezapour A., Ribeiro A.I., Roever L., Rubagotti E., Rumisha S.F., Rwegerera G.M., Sagar R., Sajadi S.M., Salem M.R., Samy A.M., Sarmiento-Suarez R., Sathian B., Schaeffer L.E., Schneider I.J.C., Seidu A.-A., Sha F., Shaikh M.A., Sharafi K.-M., Sheikh A., Shibuya K., Shin J.I., Silva D.A.S., Singh J.A., Skryabin V.Y., Skryabina A.A., Sligar A., Soheili A., Steuben K.M., Sufiyan M.B., Tadesse E.G., Tesema A.K.T., Tesfay F.H., Thapar R., Thompson R.L., Tovani-Palone M.R., Tran B.X., Tsegaye G.W., Umeokonkwo C.D., Unnikrish-Nan B., Vasseghian Y., Violante F.S., Vo B., Vu G.T., Waheed Y., Wang Y.-P., Wang Y., Ward P., Welay F.T., Westerman R., Wickramasinghe N.D., Yaya S., Yip P., Yonemoto N., Yu C., Yuce D., Yusefzadeh H., Zamanian M., Zastroz-Hin M.S., Zhang Z.-J., Zhang Y., Ziapour A., Hay S.I., Dwyer-Lindgren L., Local Burden of Disease HIV Collaborators, Clinicum, HUS Comprehensive Cancer Center, Cork, Michael A, Henry, Nathaniel J, Watson, Stefanie, Croneberger, Andrew J, Ahmed, Muktar B, Dwyer-Lindgren, Laura, Instituto de Saúde Pública da Universidade do Porto, and Collaborators, Local Burden of Disease HIV
Subjects: Male, Latin Americans, lcsh:Medicine, LOW-INCOME, HIV Infections, HIV mortality, HIV/AIDS, Latin America, Mapping, Small area estimation, Spatial statistics, Vital registration, Vital registrations, 0302 clinical medicine, ANTIRETROVIRAL THERAPY, Medicine, 030212 general & internal medicine, Registries, 11 Medical and Health Sciences, media_common, Mortality rate, 1. No poverty, DEATH, Regression analysis, General Medicine, Middle Aged, BRAZIL, Local Burden of Disease HIV Collaborators, 3. Good health, AIDS, SEX, A990 Medicine and Dentistry not elsewhere classified, Female, HEALTH, 0305 other medical science, Life Sciences & Biomedicine, Research Article, Adult, medicine.medical_specialty, Inequality, Adolescent, media_common.quotation_subject, TUBERCULOSIS, Small area estimations, 03 medical and health sciences, Medicine, General & Internal, Sex Factors, Acquired immunodeficiency syndrome (AIDS), HIV mortalities, General & Internal Medicine, Humans, Aged, Science & Technology, 030505 public health, business.industry, Public health, lcsh:R, Ecological study, HIV, Bayes Theorem, GLOBAL BURDEN, medicine.disease, TRENDS, Vital Statistics, Spatial statistic, 3121 General medicine, internal medicine and other clinical medicine, Human medicine, business, Demography
Abstract: Background Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. This paucity is partially due to incomplete vital registration (VR) systems and statistical challenges related to estimating mortality rates in areas with low numbers of HIV deaths. In this analysis, we address this gap and provide novel estimates of the HIV mortality rate and the number of HIV deaths by age group, sex, and municipality in Brazil, Colombia, Costa Rica, Ecuador, Guatemala, and Mexico. Methods We performed an ecological study using VR data ranging from 2000 to 2017, dependent on individual country data availability. We modeled HIV mortality using a Bayesian spatially explicit mixed-effects regression model that incorporates prior information on VR completeness. We calibrated our results to the Global Burden of Disease Study 2017. Results All countries displayed over a 40-fold difference in HIV mortality between municipalities with the highest and lowest age-standardized HIV mortality rate in the last year of study for men, and over a 20-fold difference for women. Despite decreases in national HIV mortality in all countries—apart from Ecuador—across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. In all six countries included in this analysis, 50% or more HIV deaths were concentrated in fewer than 10% of municipalities in the latest year of study. In addition, national age patterns reflected shifts in mortality to older age groups—the median age group among decedents ranged from 30 to 45 years of age at the municipality level in Brazil, Colombia, and Mexico in 2017. Conclusions Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. This analysis provides a framework for incorporating data and uncertainty from incomplete VR systems and can help guide more geographically precise public health intervention to support HIV-related care and reduce HIV-related deaths.
Published: 2021

74. Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study

Author: Tauana Prestes Schmidt, Danielle Soares Rocha Vieira, Cesar de Oliveira, Ione Jayce Ceola Schneider, Camila Thaís Adam, and Fernando C. Wehrmeister
Subjects: European People, Longitudinal study, Pulmonology, Physiology, Glycobiology, Pulmonary Function, Fibrinogen, Biochemistry, Hemostatics, Pulmonary function testing, Medical Conditions, Elderly, Blood plasma, Medicine and Health Sciences, Ethnicities, Longitudinal Studies, education.field_of_study, Multidisciplinary, Confounding, Middle Aged, Body Fluids, Blood, Research Design, Biomarker (medicine), Medicine, Anatomy, Research Article, medicine.drug, medicine.medical_specialty, Chronic Obstructive Pulmonary Disease, Inflammatory Diseases, Science, Population, British People, English People, Research and Analysis Methods, Blood Plasma, FEV1/FVC ratio, Internal medicine, medicine, Humans, Adults, education, Aged, Glycoproteins, business.industry, Biology and Life Sciences, Age Groups, People and Places, Population Groupings, business, Follow-Up Studies
Abstract: Background Fibrinogen is an important biomarker of inflammation, but findings from longitudinal studies that correlated fibrinogen with lung function in older adults are inconsistent. Aim To investigate the relationship between fibrinogen plasma levels and lung function impairment later in life. Methods Longitudinal analysis of 2,150 participants of the English Longitudinal Study of Ageing (ELSA) aged 50 years and older. Associations between changes in plasma fibrinogen between waves 2 (2004–05) and 4 (2008–09) and lung function in wave 6 (2012–13) were performed using multiple linear regression adjusted by potential confounders. Results Regarding the fibrinogen profile, 18.5% of the participants presented higher levels in both waves. In the adjusted models, the maintenance of high fibrinogen levels was associated with a significant reduction of lung function only for men. FEV1 showed a reduction of 0.17L, FVC of 0.22L, and the percentages predicted were 5.16% for FEV1 and 6.21% for FVC compared to those that maintained normal levels of fibrinogen. Discussion To the best of our knowledge, this was the first study investigating the relationship between changes in fibrinogen levels over a long follow-up period and lung function in older adults without pre-existing chronic diseases. ELSA has information on critical demographic and clinical parameters, which allowed to adjust for potential confounding factors. Conclusion It was found that the persistence of high levels of plasma fibrinogen in older English men, but not women, is associated with lung function decline. Therefore, plasma fibrinogen showed to be an important biomarker of pulmonary dysfunction in this population.
Published: 2021

75. Envelhecimento e dependência no Brasil: características sociodemográficas e assistenciais de idosos e cuidadores

Author: Carlos Alberto Severo Garcia Júnior, Virgínia de Menezes Portes, Roger Flores Ceccon, Luiza Jane Eyre de Souza Vieira, Konrad Gutterres Soares, Christina César Praça Brasil, Ione Jayce Ceola Schneider, and Antônio Augusto Ferreira Carioca
Subjects: Aging, 030505 public health, business.industry, Envelhecimento, Saúde do idoso, Health Policy, Public Health, Environmental and Occupational Health, Cuidador, Idoso dependente, 03 medical and health sciences, Frail older adult, 0302 clinical medicine, Caregivers, Elderly health, Medicine, Frail elderly, 030212 general & internal medicine, Public aspects of medicine, RA1-1270, 0305 other medical science, business, Humanities
Abstract: Resumo O artigo tem como objetivo identificar características sociodemográficas e assistenciais de idosos dependentes, cuidadores formais e familiares em municípios de diferentes regiões brasileiras. Realizou-se um estudo transversal com amostra de 175 pessoas, sendo 64 idosos, 27 cuidadores formais e 84 cuidadores familiares. Foram realizadas entrevistas semiestruturadas, com questões específicas para cada grupo sobre a temática do cuidado e dependência. A maioria dos idosos era do sexo feminino, com idade igual ou maior a 80 anos, com baixa escolaridade e dependente há quatro anos ou mais. Os idosos relataram sentimentos de solidão, apontaram dificuldades na assistência médica e 29% tinham acesso apenas a ações da Atenção Primária à Saúde. Entre os cuidadores familiares, encontrou-se desigualdades, sobrecargas, adoecimentos e problemas sociais. Entre os formais predominou o sexo feminino, a raça negra, sem vínculo legal de trabalho, pouca ou nenhuma formação para a função e baixa remuneração; o cuidado associou-se aos afazeres domésticos. Conclui-se que perduram as desigualdades de gênero e raça no cuidado às pessoas idosas em situação de dependência. Observou-se também que a rigidez dos papeis sociais atribuídos a homens e mulheres no Brasil persistem nas dinâmicas familiares e laborais no cuidado ao idoso dependente. Abstract This paper aims to identify sociodemographic and care characteristics of dependent older adults, formal and family caregivers in municipalities from different Brazilian regions. A cross-sectional study was carried out with a sample of 175 people, of whom 64 were older adults, 27 formal caregivers, and 84 family caregivers. Semi-structured interviews were conducted with specific questions for each group on the theme of care and dependence. Most older adults were female, aged 80 years or older, with low education and have been dependent for four years or more. Older adults reported feelings of loneliness, pointed out difficulties in medical care, and 29% had only access to Primary Health Care actions. Inequalities, burden, illnesses, and social problems were found among family caregivers. Black females with no formal employment, little or no training for the function, and low remuneration predominated among formal caregivers, and care was associated with domestic chores. We can conclude that gender and race inequalities persist in the care of dependent older adults, and we observed that the rigid social roles assigned to men and women in Brazil persist in the family and work dynamics in caring for the dependent older adults.
Published: 2021

76. Patrones de multimorbilidad e incapacidad funcional en ancianos brasileños: estudio transversal con datos de la Encuesta Nacional de Salud

Author: Ana Lúcia Danielewicz, Katia Jakovljevic Pudla Wagner, Tauana Prestes Schmidt, and Ione Jayce Ceola Schneider
Subjects: medicine.medical_specialty, Epidemiology, Anciano, 03 medical and health sciences, 0302 clinical medicine, Activities of Daily Living, Medicine, Atividades Cotidianas, Epidemiología, 030212 general & internal medicine, Epidemiologia, Aged, Gynecology, National health, 030505 public health, business.industry, Idoso, Public Health, Environmental and Occupational Health, Multimorbidity, Multimorbilidad, Functional disability, Public aspects of medicine, RA1-1270, 0305 other medical science, business, Multimorbidade, Actividades Cotidianas
Abstract: A presença de padrões de multimorbidade tem sido relacionada à incapacidade funcional nas atividades básicas (ABVD) e instrumentais (AIVD) de vida diária, que são essenciais ao autocuidado e autonomia do idoso. Assim, o objetivo do estudo foi estimar a associação dos padrões de multimorbidade com a presença de incapacidade funcional em idosos brasileiros. Tratou-se de um estudo transversal, utilizando dados da Pesquisa Nacional de Saúde (PNS 2013), realizada com idosos brasileiros (≥ 60 anos). As medidas de incapacidade funcional foram provenientes de questionários autorreferidos, categorizadas em atividades básicas de vida diária (ABVD) e atividades instrumentais de vida diária (AIVD). Os padrões de multimorbidade analisados foram: (1) cardiorespiratório; (2) vascular-metabólico; e (3) mental-musculoesquelético. As variáveis de ajuste incluíram idade, sexo, anos de estudo e região do país. Foram realizadas análises de regressão logística multivariável, estimando-se as odds ratio (OR) brutas e ajustadas, pelo software Stata 16.0. Os idosos classificados nos padrões mental-musculoesquelético tiveram maiores chances de ter incapacidade nas ABVD (OR = 2,72; IC95%: 2,33; 3,18), enquanto aqueles com padrão cardiopulmonar mostraram maiores chances de incapacidade nas AIVD (OR = 2,65; IC95%: 1,95; 3,60), quando comparados aos que não tinham os mesmos padrões de acometimento. Concluiu-se que todos os padrões de multimorbidade analisados foram associados à presença de incapacidade nas ABVD e AIVD e, assim, devem ser considerados no planejamento das ações para prevenção de incapacidades em idosos com multimorbidades. The presence of multimorbidity patterns has been related to functional disability in basic activities (BADLs) and instrumental activities of daily living (IADLs), which are essential for elder individuals’ self-care and autonomy. The study thus aimed to estimate the association between multimorbidity patterns and presence of functional disability in elderly Brazilians. This was a cross-sectional study using data from the Brazilian National Health Survey (PNS 2013) in a sample of elderly Brazilians (≥ 60 years). The measures of functional disability were from self-completed questionnaires, categorized in basic activities of daily living (BADLs) and instrumental activities of daily living (IADLs). The multimorbidity patterns analyzed here were: (1) cardiorespiratory; (2) vascular-metabolic; and (3) mental-musculoskeletal. The adjustment variables included age, sex, schooling, and region of Brazil. Multivariate logistic regression analyses were performed, estimating crude and adjusted odds ratios (OR) with Stata 16.0. Elderly individuals classified in the mental-musculoskeletal patterns showed the highest odds of disability in BADLs (OR = 2.72; 95%CI: 2.33; 3.18), while those with the cardiopulmonary pattern showed the highest odds of disability in IADLs (OR = 2.65; 95%CI: 1.95; 3.60), compared to those without the same patterns. All the multimorbidity patterns analyzed here were associated with disability in BADLs and IADLs and should thus be considered when planning measures to prevent disabilities in elderly individuals with multimorbidity. La presencia de patrones de multimorbilidad ha sido relacionada con la incapacidad funcional en actividades básicas (ABVDs) e instrumentales (AIVDs) de la vida diaria, las cuales son esenciales para el autocuidado y autonomía del anciano. De esta forma, el objetivo del estudio fue estimar la asociación de los patrones de multimorbilidad con la presencia de incapacidad funcional en ancianos brasileños. Se trató de un estudio transversal, utilizando datos de la Encuesta Nacional de Salud (PNS 2013), realizada con ancianos brasileños (≥ 60 años). Las medidas de incapacidad funcional provinieron de cuestionarios autoinformados, categorizadas en actividades básicas de vida diaria (ABVDS) y actividades instrumentales de vida diaria (AIVDS). Los patrones de multimorbilidad analizados fueron: (1) Cardiorrespiratorio; (2) Vascular-metabólico; y (3) Mental-musculoesquelético. Las variables de ajuste incluyeron edad, sexo, años de estudio y región del país. Se realizaron análisis de regresión logística multivariada, estimándose las odds ratio (OR) brutas y ajustadas, mediante el software Stata 16.0. Los ancianos clasificados en los patrones mental-musculoesquelético tuvieron mayores oportunidades de tener incapacidad en las ABVDs (OR = 2,72; IC95%: 2,33; 3,18), mientras que aquellos con patrón cardiopulmonar mostraron mayores oportunidades de incapacidad en las AIVDs (OR = 2,65; IC95%: 1,95; 3,60), cuando se comparan a los que no tenían los mismos patrones de alteraciones. Se concluyó que todos los patrones de multimorbilidad analizados estuvieron asociados con la presencia de incapacidad en las ABVDs y AIVDs, y de este modo deben ser considerados en la planificación de las acciones para la prevención de incapacidades en ancianos con multimorbilidades.
Published: 2020

77. Caffeine decreases neuromuscular fatigue in the lumbar muscles – a randomized blind study

Author: Maielen Teixeira Gonçalves, Aderbal S. Aguiar, Maria Carolina Speck, Ione Jayce Ceola Schneider, Ana Cristina de Bem Alves, Viviane José de Oliveira Bristot, Tatyana Nery, Heloyse Uliam Kuriki, Liziane Rosa Cardoso, Thais Gonçalves, and Débora da Luz Scheffer
Subjects: Rating of perceived exertion, business.industry, medicine.medical_treatment, Crossover study, chemistry.chemical_compound, Lumbar, Blood pressure, chemistry, Anesthesia, Heart rate, Motor unit recruitment, medicine, Caffeine, business, Saline
Abstract: BackgroundErgogenic evidence for caffeine is robust in sports and isolated limb tasks. Our objective was to evaluate a possible ergogenic effect on postural muscles, still unknown, through the Biering-Sørensen’s lumbar extension test.MethodsA double-blind, controlled placebo, crossover study. Fifty-one healthy, physically inactive male subjects (18-25 years) with average body mass (BMI 18.5 – 24.9 kg/m2) were recruited. The subjects received oral caffeine (6 mg/kg) and saline (0.3%) in two cross-evaluations separated by one week. The primary outcome was the time in the Biering-Sørensen test after 1 hour of treatment. The secondary outcomes were peak lumbar extension force, rating of perceived exertion, EMG’s median frequency and muscle recruitment of multifidus spinae and transversalis/interne oblique muscles, and cardiovascular variables (heart rate and blood pressure).Results27 subjects were blindly treated with caffeine and saline. Caffeine was ergogenic during the Biering-Sørensen test. It increased lumbar extension time (d = 0.34, Pd = 0.37, Pη2 = 0.49, Pmultifidus spinae. In the transversalis/interne oblique muscles, caffeine increased the median frequency η2 = 0.13, Pη2 = 0.13, PConclusionsOur results show that caffeine is ergogenic for postural muscles. Decreased RPE and improved muscle activity suggest central mechanisms of caffeine.Trial registrationUTN U1111-1234-2079.BULLET POINTSCaffeine increases the extension time of the lumbar spine in the Biering-Sørensen test.Caffeine decreases perceived exertion during the Biering-Sørensen test.Caffeine increases muscle stimulation and recruitment of the multifidus spinae during the Biering-Sørensen test.Caffeine increases muscle stimulation of the transversalis/interne oblique muscles during the Biering-Sørensen test.
Published: 2020

78. Aging and dependence in Brazil: sociodemographic and care characteristics of older adults and caregivers

Author: Roger Flores, Ceccon, Luiza Jane Eyre de Souza, Vieira, Christina César Praça, Brasil, Konrad Gutterres, Soares, Virgínia de Menezes, Portes, Carlos Alberto Severo, Garcia Júnior, Ione Jayce Ceola, Schneider, and Antonio Augusto Ferreira, Carioca
Subjects: Male, Aging, Cross-Sectional Studies, Caregivers, Activities of Daily Living, Humans, Female, Brazil, Aged
Abstract: This paper aims to identify sociodemographic and care characteristics of dependent older adults, formal and family caregivers in municipalities from different Brazilian regions. A cross-sectional study was carried out with a sample of 175 people, of whom 64 were older adults, 27 formal caregivers, and 84 family caregivers. Semi-structured interviews were conducted with specific questions for each group on the theme of care and dependence. Most older adults were female, aged 80 years or older, with low education and have been dependent for four years or more. Older adults reported feelings of loneliness, pointed out difficulties in medical care, and 29% had only access to Primary Health Care actions. Inequalities, burden, illnesses, and social problems were found among family caregivers. Black females with no formal employment, little or no training for the function, and low remuneration predominated among formal caregivers, and care was associated with domestic chores. We can conclude that gender and race inequalities persist in the care of dependent older adults, and we observed that the rigid social roles assigned to men and women in Brazil persist in the family and work dynamics in caring for the dependent older adults.O artigo tem como objetivo identificar características sociodemográficas e assistenciais de idosos dependentes, cuidadores formais e familiares em municípios de diferentes regiões brasileiras. Realizou-se um estudo transversal com amostra de 175 pessoas, sendo 64 idosos, 27 cuidadores formais e 84 cuidadores familiares. Foram realizadas entrevistas semiestruturadas, com questões específicas para cada grupo sobre a temática do cuidado e dependência. A maioria dos idosos era do sexo feminino, com idade igual ou maior a 80 anos, com baixa escolaridade e dependente há quatro anos ou mais. Os idosos relataram sentimentos de solidão, apontaram dificuldades na assistência médica e 29% tinham acesso apenas a ações da Atenção Primária à Saúde. Entre os cuidadores familiares, encontrou-se desigualdades, sobrecargas, adoecimentos e problemas sociais. Entre os formais predominou o sexo feminino, a raça negra, sem vínculo legal de trabalho, pouca ou nenhuma formação para a função e baixa remuneração; o cuidado associou-se aos afazeres domésticos. Conclui-se que perduram as desigualdades de gênero e raça no cuidado às pessoas idosas em situação de dependência. Observou-se também que a rigidez dos papeis sociais atribuídos a homens e mulheres no Brasil persistem nas dinâmicas familiares e laborais no cuidado ao idoso dependente.
Published: 2020

79. Tecnologias leves e educação em saúde no enfrentamento à pandemia da COVID-19

Author: Roger Flores Ceccon and Ione Jayce Ceola Schneider
Subjects: Nursing, Political science, Biomedical technology, Coronavirus Infections
Abstract: Este ensaio de cunho reflexivo tem o objetivo de discutir a importância das tecnologias leves e da educação em saúde no enfrentamento à pandemia da COVID-19. O texto aborda o contexto epidemiológico e as medidas de prevenção ao Coronavírus, especialmente a quarentena e o isolamento social. Além do mais, propõe um conjunto de estratégias micropolíticas que contribuem para o enfrentamento à pandemia, especialmente as tecnologias leves e a educação em saúde. Defendemos que, em tempos de pandemia, é fundamental a humanização do cuidado, o diálogo e as relações de confiança entre profissionais e usuários. As reflexões suscitadas constituem-se como práxis transversais ao trabalho e caracterizam-se como compromissos éticos, estéticos e políticos no enfrentamento à pandemia, necessárias para a produção de sentido e sensibilização das ações impostas por autoridades sanitárias.
Published: 2020

80. Racial inequities in tooth loss among older Brazilian adults: A decomposition analysis

Author: Rafael Aiello Bomfim, Maria Fernanda Lima-Costa, Paulo Frazão, Richard G. Watt, Vanessa Pereira Corrêa, Fabíola Bof de Andrade, João Luiz Bastos, Ione Jayce Ceola Schneider, and Cesar de Oliveira
Subjects: Adult, Longitudinal study, medicine.medical_specialty, Decomposition analysis, Logistic regression, 03 medical and health sciences, Tooth Loss, Young Adult, 0302 clinical medicine, stomatognathic system, Epidemiology, Tooth loss, medicine, Humans, 030212 general & internal medicine, Longitudinal Studies, General Dentistry, Socioeconomic status, Depression (differential diagnoses), Aged, business.industry, Public Health, Environmental and Occupational Health, 030206 dentistry, Middle Aged, stomatognathic diseases, Cross-Sectional Studies, Socioeconomic Factors, Income, Educational Status, Smoking status, medicine.symptom, business, Brazil, Demography
Abstract: Objective To determine the extent to which racial inequities in tooth loss and functional dentition are explained by individual socioeconomic status, smoking status and frequency/reason for the use of dental services. Methods Data came from the Brazilian Longitudinal Study of Ageing, a nationally representative sample of community-dwelling people aged 50 years and over. Tooth loss and functional dentition (ie 20+ natural teeth) were the outcomes. The main explanatory variable was self-classified race. Covariates included dental visits in the past 12 months, dental visits for check-ups only, smoking status, self-reported chronic conditions, depression and cognitive function. Logistic regression and Blinder-Oaxaca decomposition analysis were used to estimate the share of each factor in race-related tooth loss inequities. Results The analytical sample comprised of 7126 respondents. While the prevalence of functional dentition in White Brazilians was 37% (95% CI: 33.5;40.9), it was 29% (95% CI: 26.4;31.6) among Browns and 30% (95% CI: 25.1;35.4) among Blacks. The average number of lost teeth among Whites, Browns and Blacks were 18.7 (95% CI: 17.8;19.6), 20.4 (95% CI: 19.7;21.1) and 20.8 (95% CI: 19.5;22.0), respectively. Decomposition analysis showed that the selected covariates explained 71% of the racial inequalities in tooth loss. Dental visits in the previous year and smoking status explained nearly half of race-related gaps. Other factors, such as per capita income, education and cognitive status, also had an important contribution to the examined inequalities. The proportion of racial inequities in tooth loss that was explained by dental visits (frequency and reason) and smoking status decreased from 40% for those 50-59 years of age to 22% among participants aged 70-79 years. Conclusions Frequency and reason for dental visits and smoking status explained nearly half of the racial inequity in tooth loss among Brazilian older adults. The Brazilian Family Health Strategy Program should target older adults from racial groups living in deprived areas.
Published: 2020

81. Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017

Author: Hassan Haghparast Bidgoli, Young Eun Kim, Duduzile Ndwandwe, Marilita M Moschos, Diego De Leo, Mark A. Stokes, Faris Lami, Lorenzo Monasta, Amit Arora, Hamid Asayesh, Dhirendra N Sinha, Ferrán Catalá-López, Ana Maria Nogales Vasconcelos, Swayam Prakash, Rafael Tabarés-Seisdedos, Melkamu Merid Mengesha, Yuichiro Yano, Olalekan A. Uthman, Amir Radfar, Manasi Kumar, Kamarul Imran Musa, Babak Moazen, Spencer L. James, Ahmad Daryani, Achala Upendra Jayatilleke, Siavash Rahimi, Carl Abelardo T. Antonio, Morteza Abdullatif Khafaie, Meysam Behzadifar, Dan J. Stein, Kathryn H. Jacobsen, Jiabin Shen, Rajesh Kumar Rai, Ehimario U. Igumbor, Amir Kasaeian, Ali Kabir, Morteza Shamsizadeh, Ziad El-Khatib, Sharareh Eskandarieh, Sorin Hostiuc, Jarnail Singh Thakur, Takeshi Fukumoto, Shai Linn, João Pedro Silva, Olayinka Stephen Ilesanmi, Gizachew Assefa Tessema, Naohiro Yonemoto, Jacek Jerzy Jozwiak, Masood Ali Shaikh, Seyyed Meysam Mousavi, Syed Mohamed Aljunid, Azeem Majeed, Alexandra Brazinova, Nader Jahanmehr, Yuming Guo, Sonia Saxena, Juanita A. Haagsma, Devasahayam J. Christopher, Lorainne Tudor Car, Shamsa Zafar, Roghayeh Mohammadibakhsh, Khanh Bao Tran, Reza Malekzadeh, Martha Híjar, Addisu Melese, Tinuke O Olagunju, Guoqing Hu, Yousef Khader, Olatunde Aremu, Yahya Salimi, Corina Benjet, Seyed-Mohammad Fereshtehnejad, Julio Cesar Campuzano Rincon, Rizwan Kalani, Bach Xuan Tran, Serge Resnikoff, Félix Carvalho, Suzanne Barker-Collo, Basema Saddik, Abraham Getachew Kelbore, Chris D Castle, Andre Pascal Kengne, Joan B. Soriano, Aliasghar Ahmad Kiadaliri, Derrick A Bennett, Pedro R. Olivares, Ali Bijani, Shanshan Li, Srinivas Murthy, Dragos Virgil Davitoiu, Farid Najafi, Seyed Sina Naghibi Irvani, Maziar Moradi-Lakeh, Adauto Martins Soares Filho, Vasily Vlassov, Alessandra C. Goulart, Alireza Ahmadi, Theo Vos, Heather Orpana, Narayan Bahadur Mahotra, Dillon O Sylte, Tuomo J. Meretoja, Ireneous N. Soyiri, Susan M Sawyer, Nauman Khalid, Louisa Degenhardt, Kebede Embaye Gezae, Ubai Alsharif, Richard C. Franklin, Shane D. Morrison, Randah R. Hamadeh, G. K. Mini, Naznin Hossain, Zachary V Dingels, Kate Dolan, Florian Fischer, Atte Meretoja, Yasir Waheed, Milena M Santric Milicevic, Ai Koyanagi, Sadaf G. Sepanlou, Manisha Dubey, Michael Phillips, Koustuv Dalal, Maysaa El Sayed Zaki, Elena Varavikova, Rahul Gupta, Rajaa Al-Raddadi, Sergey Soshnikov, David Laith Rawaf, Zoubida Zaidi, David C. Schwebel, Hassan Magdy Abd El Razek, Jost B. Jonas, Flávia Ribeiro Machado, Yoshan Moodley, Stefania Mondello, Nicholas L S Roberts, N. Bedi, Amrit Banstola, Yong Zhao, Vladimir I. Starodubov, Beatriz Paulina Ayala Quintanilla, Juan Jesus Carrero, Manzoor Ahmad Malik, George C Patton, André Faro, In-Hwan Oh, Anwar Rafay, Simon I. Hay, Deborah Carvalho Malta, Erin B Hamilton, Man Mohan Mehndiratta, Suliman Alghnam, Olanrewaju Oladimeji, Sojib Bin Zaman, Ratilal Lalloo, Zichen Liu, Mahmood Moosazadeh, Isabela M. Benseñor, Muluken Azage Yenesew, Ivy Shiue, Hilton Lam, Soraya Seedat, Mete Saylan, Eduarda Fernandes, Khalid A Altirkawi, Chuanhua Yu, Jasvinder A. Singh, Pascual R. Valdez, Jan-Walter De Neve, Guilherme Borges, Seth Christopher Yaw Appiah, Linh Phuong Doan, Christopher S. Crowe, Andualem Henok, Carlos A Castañeda-Orjuela, Mina Anjomshoa, Bruno Ramos Nascimento, Paul S. F. Yip, Samath D Dharmaratne, Ayman Grada, Christian Lycke Ellingsen, Zulfiqar A Bhutta, Gurudatta Naik, Shahrzad Bazargan-Hejazi, Tomislav Mestrovic, Long Hoang Nguyen, Karen M. Tabb, Kebede Deribe, Mustafa Z. Younis, Yuan-Pang Wang, Van C. Lansingh, Felix Akpojene Ogbo, Mihajlo Jakovljevic, Till Bärnighausen, Naser Mohammad Gholi Mezerji, Kiana Ramezanzadeh, Muhammed Magdy Abd El Razek, Rasmus Havmoeller, Konrad Pesudovs, Salman Rawaf, Walter Mendoza, Smita Pakhale, Mahesh P A, Ted R. Miller, Rebecca Ivers, Gabrielle deVeber, Pallab K. Maulik, Ali H. Mokdad, Burcu Kucuk Bicer, Andre M. N. Renzaho, Muhammad Aziz Rahman, Fares Alahdab, Vafa Rahimi-Movaghar, Dipan Bose, Alireza Rafiei, Payman Salamati, Engida Yisma, Huong Lan Thi Nguyen, Juan Sanabria, Priyanka Yadav, Andrew T Olagunju, Ejaz Ahmad Khan, Irina Filip, Shahab Rezaeian, Ghobad Moradi, Mohammad Zamani, Rosario Cárdenas, Delia Hendrie, Yogesh Sabde, Marek Majdan, Mariam Molokhia, Adnan Kisa, Jacob E. Sunshine, Narayanaswamy Venketasubramanian, Mahdi Sharif-Alhoseini, Sanjay Zodpey, Ashish Awasthi, Rahman Shiri, Zahra Jorjoran Shushtari, Shivanthi Balalla, Samer Hamidi, Hailemariam Abiy Alemu Meheretu, Raimundas Lunevicius, Suzanne Polinder, Tomasz Miazgowski, Sheikh Mohammed Shariful Islam, Tim Driscoll, Son Hoang Nguyen, Mika Shigematsu, Bryan L. Sykes, Arash Tehrani-Banihashemi, Dina Nur Anggraini Ningrum, Josep Maria Haro, Leonardo Roever, Gholamreza Roshandel, Andrea Sylvia Winkler, Mehran Shams-Beyranvand, Ilais Moreno Velásquez, Luca Ronfani, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Jee-Young Jasmine Choi, Mohammad Ali Mansournia, Daniel Kim, Maheswar Satpathy, Ionut Negoi, Michael K. Hole, Miloud Taki Eddine Aichour, Erkin M. Mirrakhimov, Barthelemy Kuate Defo, Alan D. Lopez, Masoud Behzadifar, Rohan Borschmann, Ana-Laura Manda, Ione Jayce Ceola Schneider, Lydia R. Lucchesi, Trang Huyen Nguyen, Mu'awiyyah Babale Sufiyan, Janet L Leasher, Shafiu Mohammed, Lidia Morawska, Getenet Dessie, Reza Assadi, Tiffany K. Gill, Francesco Saverio Violante, Monika Sawhney, Enayatollah Homaie Rad, Yirga Legesse Nirayo, Muktar Beshir Ahmed, Oladimeji Adebayo, Mikk Jürisson, Soumyadeep Bhaumik, Hadi Hassankhani, Stanislav S. Otstavnov, Aziz Sheikh, Benjamin Uzochukwu, Aman Yesuf Endries, Eun-Kee Park, Jack T Fox, Abdallah M. Samy, Richard Ofori-Asenso, Ravi Prakash Jha, Inbal Salz, Benjamin B. Massenburg, Soufiane Boufous, Hamid Yimam Hassen, Pablo Montero-Zamora, Tissa Wijeratne, Abdullah T Khoja, Lidia Sanchez Riera, Vinay Nangia, Bill & Melinda Gates Foundation, Haagsma, Juanita A, James, Spencer L, Castle, Chris D, Dingels, Zachary V, Yisma, Engida, Vos, Theo, Haagsma J.A., James S.L., Castle C.D., Dingels Z.V., Fox J.T., Hamilton E.B., Liu Z., Lucchesi L.R., Roberts N.L.S., Sylte D.O., Adebayo O.M., Ahmadi A., Ahmed M.B., Aichour M.T.E., Alahdab F., Alghnam S.A., Aljunid S.M., Al-Raddadi R.M., Alsharif U., Altirkawi K., Anjomshoa M., Antonio C.A.T., Appiah S.C.Y., Aremu O., Arora A., Asayesh H., Assadi R., Awasthi A., Ayala Quintanilla B.P., Balalla S., Banstola A., Barker-Collo S.L., Barnighausen T.W., Bazargan-Hejazi S., Bedi N., Behzadifar M., Benjet C., Bennett D.A., Bensenor I.M., Bhaumik S., Bhutta Z.A., Bijani A., Borges G., Borschmann R., Bose D., Boufous S., Brazinova A., Campuzano Rincon J.C., Cardenas R., Carrero J.J., Carvalho F., Castaneda-Orjuela C.A., Catala-Lopez F., Choi J.-Y.J., Christopher D.J., Crowe C.S., Dalal K., Daryani A., Davitoiu D.V., Degenhardt L., De Leo D., De Neve J.-W., Deribe K., Dessie G.A., Deveber G.A., Dharmaratne S.D., Doan L.P., Dolan K.A., Driscoll T.R., Dubey M., El-Khatib Z., Ellingsen C.L., El Sayed Zaki M., Endries A.Y., Eskandarieh S., Faro A., Fereshtehnejad S.-M., Fernandes E., Filip I., Fischer F., Franklin R.C., Fukumoto T., Gezae K.E., Gill T.K., Goulart A.C., Grada A., Guo Y., Gupta R., Haghparast Bidgoli H., Haj-Mirzaian A., Hamadeh R.R., Hamidi S., Haro J.M., Hassankhani H., Hassen H.Y., Havmoeller R., Hendrie D., Henok A., Hijar M., Hole M.K., Homaie Rad E., Hossain N., Hostiuc S., Hu G., Igumbor E.U., Ilesanmi O.S., Irvani S.S.N., Islam S.M.S., Ivers R.Q., Jacobsen K.H., Jahanmehr N., Jakovljevic M., Jayatilleke A.U., Jha R.P., Jonas J.B., Jorjoran Shushtari Z., Jozwiak J.J., Jurisson M., Kabir A., Kalani R., Kasaeian A., Kelbore A.G., Kengne A.P., Khader Y.S., Khafaie M.A., Khalid N., Khan E.A., Khoja A.T., Kiadaliri A.A., Kim Y.-E., Kim D., Kisa A., Koyanagi A., Kuate Defo B., Kucuk Bicer B., Kumar M., Lalloo R., Lam H., Lami F.H., Lansingh V.C., Leasher J.L., Li S., Linn S., Lunevicius R., MacHado F.R., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahotra N.B., Majdan M., Majeed A., Malekzadeh R., Malik M.A., Malta D.C., Manda A.-L., Mansournia M.A., Massenburg B.B., Maulik P.K., Meheretu H.A.A., Mehndiratta M.M., Melese A., Mendoza W., Mengesha M.M., Meretoja T.J., Meretoja A., Mestrovic T., Miazgowski T., Miller T.R., Mini G.K., Mirrakhimov E.M., Moazen B., Mohammad Gholi Mezerji N., Mohammadibakhsh R., Mohammed S., Molokhia M., Monasta L., Mondello S., Montero-Zamora P.A., Moodley Y., Moosazadeh M., Moradi G., Moradi-Lakeh M., Morawska L., Velasquez I.M., Morrison S.D., Moschos M.M., Mousavi S.M., Murthy S., Musa K.I., Naik G., Najafi F., Nangia V., Nascimento B.R., Ndwandwe D.E., Negoi I., Nguyen T.H., Nguyen S.H., Nguyen L.H., Nguyen H.L.T., Ningrum D.N.A., Nirayo Y.L., Ofori-Asenso R., Ogbo F.A., Oh I.-H., Oladimeji O., Olagunju A.T., Olagunju T.O., Olivares P.R., Orpana H.M., Otstavnov S.S., Mahesh P.A., Pakhale S., Park E.-K., Patton G.C., Pesudovs K., Phillips M.R., Polinder S., Prakash S., Radfar A., Rafay A., Rafiei A., Rahimi S., Rahimi-Movaghar V., Rahman M.A., Rai R.K., Ramezanzadeh K., Rawaf S., Rawaf D.L., Renzaho A.M.N., Resnikoff S., Rezaeian S., Roever L., Ronfani L., Roshandel G., Sabde Y.D., Saddik B., Salamati P., Salimi Y., Salz I., Samy A.M., Sanabria J., Sanchez Riera L., Santric Milicevic M.M., Satpathy M., Sawhney M., Sawyer S.M., Saxena S., Saylan M., Schneider I.J.C., Schwebel D.C., Seedat S., Sepanlou S.G., Shaikh M.A., Shams-Beyranvand M., Shamsizadeh M., Sharif-Alhoseini M., Sheikh A., Shen J., Shigematsu M., Shiri R., Shiue I., Silva J.P., Singh J.A., Sinha D.N., Soares Filho A.M., Soriano J.B., Soshnikov S., Soyiri I.N., Starodubov V.I., Stein D.J., Stokes M.A., Sufiyan M.B., Sunshine J.E., Sykes B.L., Tabares-Seisdedos R., Tabb K.M., Tehrani-Banihashemi A., Tessema G.A., Thakur J.S., Tran K.B., Tran B.X., Tudor Car L., Uthman O.A., Uzochukwu B.S.C., Valdez P.R., Varavikova E., Vasconcelos A.M.N., Venketasubramanian N., Violante F.S., Vlassov V., Waheed Y., Wang Y.-P., Wijeratne T., Winkler A.S., Yadav P., Yano Y., Yenesew M.A., Yip P., Yisma E., Yonemoto N., Younis M.Z., Yu C., Zafar S., Zaidi Z., Zaman S.B., Zamani M., Zhao Y., Zodpey S., Hay S.I., Lopez A.D., Mokdad A.H., Vos T., Public Health, HUS Comprehensive Cancer Center, Clinicum, Department of Surgery, University of Helsinki, Helsinki University Hospital Area, and HUS Neurocenter
Subjects: Epidemiology, burden of disease, descriptive epidemiology, epidemiology, ECONOMIC-DEVELOPMENT, 1106 Human Movement and Sports Sciences, Poison control, Global Health, Global Burden of Disease, 0302 clinical medicine, Quality-Adjusted Life Year, Global health, 030212 general & internal medicine, 10. No inequality, 1. No poverty, Burden of disease, DALYS, 3142 Public health care science, environmental and occupational health, ddc, 3. Good health, Descriptive epidemiology, Epidemiological transition, REGISTRATION, Disabled Person, Public Health, Human, medicine.medical_specialty, DEATHS, Adolescent, 1117 Public Health and Health Services, 03 medical and health sciences, Life Expectancy, Injury prevention, SYSTEMATIC ANALYSIS, medicine, Disability-adjusted life year, Disease burden, Estimation, burden of disease, descriptive epidemiology, epidemiology, MORTALITY, Public health, EPIDEMIOLOGIC TRANSITION, Public Health, Environmental and Occupational Health, 030208 emergency & critical care medicine, TRENDS, EXPECTANCY HALE, 1701 Psychology, Wounds and Injuries, Human medicine, Demography
Abstract: Incluye: Correction: Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017. Inj Prev. 2020 Oct;26(Supp 1):i164. doi: 10.1136/injuryprev-2019-043296corr1. Epub 2020 Sep 28. PMID: 32989004 Background: The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates. Methods: Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate. Results: For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced. Conclusions: The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum. Funding for GBD 2017 was provided by the Bill and Melinda Gates Foundation. Sí
Published: 2020

82. [Multimorbidity patterns and functional disability in elderly Brazilians: a cross-sectional study with data from the Brazilian National Health Survey]

Author: Tauana Prestes, Schmidt, Katia Jakovljevic Pudla, Wagner, Ione Jayce Ceola, Schneider, and Ana Lúcia, Danielewicz
Subjects: Cross-Sectional Studies, Activities of Daily Living, Humans, Multimorbidity, Disabled Persons, Health Surveys, Brazil, Aged
Abstract: The presence of multimorbidity patterns has been related to functional disability in basic activities (BADLs) and instrumental activities of daily living (IADLs), which are essential for elder individuals' self-care and autonomy. The study thus aimed to estimate the association between multimorbidity patterns and presence of functional disability in elderly Brazilians. This was a cross-sectional study using data from the Brazilian National Health Survey (PNS 2013) in a sample of elderly Brazilians (≥ 60 years). The measures of functional disability were from self-completed questionnaires, categorized in basic activities of daily living (BADLs) and instrumental activities of daily living (IADLs). The multimorbidity patterns analyzed here were: (1) cardiorespiratory; (2) vascular-metabolic; and (3) mental-musculoskeletal. The adjustment variables included age, sex, schooling, and region of Brazil. Multivariate logistic regression analyses were performed, estimating crude and adjusted odds ratios (OR) with Stata 16.0. Elderly individuals classified in the mental-musculoskeletal patterns showed the highest odds of disability in BADLs (OR = 2.72; 95%CI: 2.33; 3.18), while those with the cardiopulmonary pattern showed the highest odds of disability in IADLs (OR = 2.65; 95%CI: 1.95; 3.60), compared to those without the same patterns. All the multimorbidity patterns analyzed here were associated with disability in BADLs and IADLs and should thus be considered when planning measures to prevent disabilities in elderly individuals with multimorbidity.A presença de padrões de multimorbidade tem sido relacionada à incapacidade funcional nas atividades básicas (ABVD) e instrumentais (AIVD) de vida diária, que são essenciais ao autocuidado e autonomia do idoso. Assim, o objetivo do estudo foi estimar a associação dos padrões de multimorbidade com a presença de incapacidade funcional em idosos brasileiros. Tratou-se de um estudo transversal, utilizando dados da Pesquisa Nacional de Saúde (PNS 2013), realizada com idosos brasileiros (≥ 60 anos). As medidas de incapacidade funcional foram provenientes de questionários autorreferidos, categorizadas em atividades básicas de vida diária (ABVD) e atividades instrumentais de vida diária (AIVD). Os padrões de multimorbidade analisados foram: (1) cardiorespiratório; (2) vascular-metabólico; e (3) mental-musculoesquelético. As variáveis de ajuste incluíram idade, sexo, anos de estudo e região do país. Foram realizadas análises de regressão logística multivariável, estimando-se as odds ratio (OR) brutas e ajustadas, pelo software Stata 16.0. Os idosos classificados nos padrões mental-musculoesquelético tiveram maiores chances de ter incapacidade nas ABVD (OR = 2,72; IC95%: 2,33; 3,18), enquanto aqueles com padrão cardiopulmonar mostraram maiores chances de incapacidade nas AIVD (OR = 2,65; IC95%: 1,95; 3,60), quando comparados aos que não tinham os mesmos padrões de acometimento. Concluiu-se que todos os padrões de multimorbidade analisados foram associados à presença de incapacidade nas ABVD e AIVD e, assim, devem ser considerados no planejamento das ações para prevenção de incapacidades em idosos com multimorbidades.La presencia de patrones de multimorbilidad ha sido relacionada con la incapacidad funcional en actividades básicas (ABVDs) e instrumentales (AIVDs) de la vida diaria, las cuales son esenciales para el autocuidado y autonomía del anciano. De esta forma, el objetivo del estudio fue estimar la asociación de los patrones de multimorbilidad con la presencia de incapacidad funcional en ancianos brasileños. Se trató de un estudio transversal, utilizando datos de la Encuesta Nacional de Salud (PNS 2013), realizada con ancianos brasileños (≥ 60 años). Las medidas de incapacidad funcional provinieron de cuestionarios autoinformados, categorizadas en actividades básicas de vida diaria (ABVDS) y actividades instrumentales de vida diaria (AIVDS). Los patrones de multimorbilidad analizados fueron: (1) Cardiorrespiratorio; (2) Vascular-metabólico; y (3) Mental-musculoesquelético. Las variables de ajuste incluyeron edad, sexo, años de estudio y región del país. Se realizaron análisis de regresión logística multivariada, estimándose las odds ratio (OR) brutas y ajustadas, mediante el software Stata 16.0. Los ancianos clasificados en los patrones mental-musculoesquelético tuvieron mayores oportunidades de tener incapacidad en las ABVDs (OR = 2,72; IC95%: 2,33; 3,18), mientras que aquellos con patrón cardiopulmonar mostraron mayores oportunidades de incapacidad en las AIVDs (OR = 2,65; IC95%: 1,95; 3,60), cuando se comparan a los que no tenían los mismos patrones de alteraciones. Se concluyó que todos los patrones de multimorbilidad analizados estuvieron asociados con la presencia de incapacidad en las ABVDs y AIVDs, y de este modo deben ser considerados en la planificación de las acciones para la prevención de incapacidades en ancianos con multimorbilidades.
Published: 2019

83. Abandono do tratamento e cessação do tabagismo: análise dos dados de um programa de controle

Author: Ione Jayce Ceola Schneider, Bruna Vanti da Rocha, and Danielle Soares Rocha Vieira
Subjects: business.industry, medicine.medical_treatment, Tobacco control, General Medicine, Impulsivity, Quit smoking, Nicotine Addiction, Nicotine, medicine, Smoking cessation, Health information, medicine.symptom, business, Depressive symptoms, medicine.drug, Demography
Abstract: Objetivo: analisar o perfil dos tabagistas em tratamento e os fatores associados ao abandono do tratamento e cessação do tabagismo em um programa municipal. Método: estudo transversal realizado em Araranguá, Santa Catarina com 109 pessoas do Programa Controle do Tabagismo, entre março e dezembro de 2018. Foram coletadas informações sociodemográficas e de saúde, incluindo sintomas depressivos, impulsividade e capacidade de enfrentamento. Realizou-se análises descritivas e inferenciais. Resultados: 40,4% dos participantes abandonaram o tratamento, grupo que obteve maior média para impulsividade. Os principais motivos relatados para o abandono do tratamento foram: “estar bem sem fumar”, situações relacionadas ao trabalho e sintomas de abstinência. Observou-se que 7,64% cessaram o tabagismo e 93,8% apresentavam dependência leve à nicotina. Conclusão: apesar do abandono ser alto, alguns permaneceram em cessação. Os com 49 anos ou menos foram tiveram abandono significativamente maior e a dependência à nicotina apresenta-se como dificultador significativo da cessação.
Published: 2021

84. Anthropometric indicators as a screening tool for sarcopenia in older adults from Florianópolis, Santa Catarina: EpiFloripa Ageing study

Author: Aline Rodrigues Barbosa, Susana Cararo Confortin, Lariane Mortean Ono, Eleonora d'Orsi, Vandrize Meneghini, and Ione Jayce Ceola Schneider
Subjects: Gerontology, Sarcopenia, Waist, Population, Medicine (miscellaneous), lcsh:TX341-641, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Força da mão, 030502 gerontology, Medicine, 030212 general & internal medicine, education, Aged, education.field_of_study, Nutrition and Dietetics, Anthropometry, Receiver operating characteristic, business.industry, Idoso, Curva ROC, musculoskeletal system, Circumference, medicine.disease, ROC curve, body regions, Hand strength, 0305 other medical science, business, lcsh:Nutrition. Foods and food supply, human activities, Body mass index, Antropometria
Abstract: Objective This cross-sectional population-based study aimed to determine the cutoff points of anthropometric indicators to screen for sarcopenia and the association between sarcopenia and these indicators. Methods The sample consisted of 601 older adults. Sarcopenia was detected by appendicular skeletal muscle index. The receiver operating characteristic curve identified the cutoff points for body mass index, waist-to-height ratio, waist circumference, and handgrip strength to screen for sarcopenia. Based on the cut-off points, principal component analysis determined which indicators had a better fit as discriminants to compose an indicator. Finally, logistic regression analysis was performed with this indicator as the main independent variable. Results The results showed that all anthropometric indicators and handgrip strength were capable of discriminating sarcopenia; however, body mass index, waist circumference, and waist-to-height ratio were the best discriminants in principal components analysis, composing the new indicator. Adjusted logistic regression analysis showed that sarcopenia was associated with the indicator in both sexes. Conclusion The concomitant presence of low body mass index, low waist circumference, and low waist-to-height ratio may help to discriminate sarcopenia. RESUMO Objetivo Este estudo transversal, populacional, teve como objetivo determinar pontos de corte de indicadores antro-pométricos e força de preensão manual para triagem de sarcopenia e verificar a associação entre sarcopenia e estes indicadores. Métodos A amostra foi composta por 601 idosos e a sarcopenia foi identificada pelo índice de massa muscular apendicular. A curva Receiver Operating Characteristic identificou os valores de pontos de corte para: índice de massa corporal, razão cintura-estatura, perímetro de cintura e força de preensão manual para triagem da sarcopenia. A partir dos pontos de corte foi realizada análise de componentes principais para definir os que mais se adequaram como discriminantes, compondo um indicador, e realizado análise de regressão logística com este indicador como variável independente principal. Resultados Os resultados mostraram que todos os indicadores antropométricos e a força de preensão manual foram considerados discriminadores de sarcopenia, entretanto o índice de massa corporal, o perímetro da cintura e a razão cintura estatura mostram-se como os melhores discriminantes na análise de componentes principais, compondo o novo indicador. A análise de regressão logística (ajustada) mostrou que a sarcopenia foi associada com o indicador em ambos os sexos. Conclusão A presença de índice de massa corporal baixo, baixa relação cintura estatura e baixo perímetro da cintura concomitantemente podem auxiliar na discriminação da sarcopenia.
Published: 2017

85. Municipalities Stratification for Health Performance Evaluation

Author: Thiago Augusto Hernandes Rocha, Ione Jayce Ceola Schneider, Claudia Flemming Colussi, Josimari Telino de Lacerda, and Maria Cristina Marino Calvo
Subjects: Health Management, Health Evaluation, lcsh:Public aspects of medicine, Research, 030503 health policy & services, lcsh:R, Methodology, lcsh:Medicine, Metodologia, lcsh:RA1-1270, General Medicine, Metodología, Pesquisa, Gestão em Saúde, 03 medical and health sciences, 0302 clinical medicine, Gestión en Salud, Investigación, Avaliação em Saúde, 030212 general & internal medicine, 0305 other medical science, Evaluación en Salud
Abstract: Resumo OBJETIVO: propor e apresentar aplicação de estratificação dos municípios brasileiros em grupos homogêneos para estudos de avaliação de desempenho da gestão em saúde. MÉTODOS: estudo metodológico com classificação dos municípios segundo as condições que influenciam a gestão em saúde e porte populacional; dados referentes ao ano de 2010 foram compilados de bases demográficas e de saúde; testes de correlação e análise fatorial foram utilizados. RESULTADOS: identificaram-se sete estratos - Grande porte; Médio porte com influentes favoráveis, regulares ou desfavoráveis; e Pequeno porte com influentes favoráveis, regulares ou desfavoráveis -; houve concentração de municípios com influentes favoráveis nas faixas de melhor poder aquisitivo e de financiamento, e concentração de municípios com influentes desfavoráveis nas regiões Norte e Nordeste. CONCLUSÃO: a classificação proposta agrupou municípios semelhantes quanto aos fatores influentes da gestão em saúde, permitindo a identificação de grupos comparáveis de municípios e configurando uma alternativa consistente para estudos de avaliação de desempenho. Abstract OBJECTIVE: to propose and present a stratification of Brazilian municipalities into homogeneous groups for evaluation studies of health management performance. METHODS: this was a methodological study, with selected indicators which classify municipalities according to conditions that influence the health management and population size; data for the year 2010 were collected from demographic and health databases; correlation tests and factor analysis were used. RESULTS: seven strata were identified - Large-sized; Medium-sized with favorable, regular or unfavorable influences; and Small-sized with favorable, regular or unfavorable influences -; there was a concentration of municipalities with favorable influences in strata with better purchasing power and funding, as well as a concentration of municipalities with unfavorable influences in the North and Northeast regions. CONCLUSION: the proposed classification grouped similar municipalities regarding influential factors in health management, which allowed the identification of comparable groups of municipalities, setting up a consistent alternative to performance evaluation studies. Resumen OBJETIVO: proponer y presentar la estratificación de municipios brasileños en grupos homogéneos para estudios de evaluación del desempeño de la gestión en salud. MÉTODOS: estudio metodológico, con la clasificación de municipios en función de las condiciones que influyen en la gestión de la salud y tamaño de población; los datos para el año 2010 fueran compilados en las bases demográficas y de salud; se utilizaron pruebas de correlación y análisis factorial. RESULTADOS: se identificaron siete estratos según el tamaño - grande; medio con condiciones favorables, regular o desfavorables; y pequeño con condiciones favorables, regular o desfavorables -; los municipios con condiciones favorables se centran en las mejores condiciones de poder adquisitivo y financiamiento, así como la condición desfavorable en el Norte y Nordeste. CONCLUSIÓN: la clasificación propuesta agrupa municipios similares, lo que permitió la identificación de grupos comparables entre municipios, constituyendo una alternativa coherente con estudios de evaluación de desempeño.
Published: 2016

86. INCAPACIDADE FUNCIONAL E INTENSIDADE DA DOR NA LOMBALGIA CRÔNICA INESPECÍFICA EM TRABALHADORES DE ENFERMAGEM

Author: Mara Ambrosina de Oliveira Vargas, Dulcinéia Ghizoni Schneider, Zulamar Aguiar Cargnin, and Ione Jayce Ceola Schneider
Subjects: Nursing, Pain measurement, Worker’s health: Occupational Diseases. [Low Back Pain], Dor Lombar, Enfermagem, Medição da Dor, Saúde do Trabalhador, Doenças Profissionais, Saúde do trabalhador, doenças ocupacionais, General Nursing, Dolor Lumbar, Enfermería, Medición del Dolor, Salud del Trabajador, Enfermedades Profesionales
Abstract: Objetivo: determinar a intensidade da dor e a incapacidade funcional em portadores de dor lombarcrônica inespecífica.Método: estudo transversal com 90 trabalhadores da enfermagem de um hospital público entreagosto e outubro de 2017. Empregou-se Questionário de Roland Morris e Escala Visual Numérica.Procederam-se análises bivariadas, correlações de Pearson ou Spearman e teste Anova paracomparação de médias.Resultado: a intensidade da dor foi moderada e associada com Índice de Massa Corpórea e limitaçãoem atividades de vida diária e trabalho. A incapacidade funcional mostrou-se baixa e relacionadaao duplo emprego na enfermagem e faixa etária de 41 a 50 anos. A relação entre intensidade dador e incapacidade foi significativa, positiva e moderada.Conclusão: a intensidade da dor lombar e incapacidade funcional associaram-se a fatores laborais eindividuais. A identificação desses fatores pode favorecer a implementação de medidas preventivase guiar intervenções reabilitativas mais elaboradas e específicas. Objetivo: determinar la intensidad del dolor y la incapacidad funcional en portadores dedolor lumbar crónica inespecífica.Método: estudio trasversal con 90 trabajadores de enfermería de un hospital público, hechoentre agosto y octubre de 2017. Se utilizó cuestionario de Roland Morris y Escala VisualNumérica. Se hicieron análisis bivariados, correlaciones de Pearson o Spearman y test Anovapara comparación de promedios.Resultado: la intensidad del dolor fue moderada y se la asoció al Índice de Masa Corpóreay limitación en actividades de vida diaria y trabajo. La incapacidad funcional se reveló baja yrelacionada a la doble jornada en la enfermería, además de franja etaria de 41 a 50 años. Larelación entre intensidad del dolor e incapacidad fue significativa, positiva y moderada.Conclusión: la intensidad del dolor lumbar así como la incapacidad funcional se asociarona factores laborales e individuales. La identificación de esos factores puede favorecer laimplementación de medidas preventivas y orientar intervenciones de rehabilitación másapropiadas y específicas. Objective: To determine pain intensity and functional disability in patients with non-specificchronic low back pain.Method: Cross-sectional study with 90 nursing workers of a public hospital conducted betweenAugust and October 2017. The Roland Morris Questionnaire and Visual Numerical Scale wereused. Bivariate analyzes, Pearson or Spearman correlations and Anova test for comparison ofmeans were performed.Result: Pain intensity was moderate and associated with Body Mass Index and limitation inactivities of daily living and reduction of work productivity. Functional disability was low andrelated to having more than one nursing job and aged 41- 50 years.Conclusion: Low back pain intensity and functional disability were associated with workand individual factors. The identification of these factors may favor the implementation ofpreventive measures and guide more accurate and specific rehabilitation interventions. Therelationship between the intensity of pain and disability was significant, positive and moderate.
Published: 2019
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87. Indicadores antropométricos associados à demência em idosos de Florianópolis – SC, Brasil: Estudo EpiFloripa Idoso

Author: Aline Rodrigues Barbosa, Ione Jayce Ceola Schneider, Susana Cararo Confortin, Lariane Mortean Ono, Eleonora d'Orsi, Vandrize Meneghini, and Karyne Claudete Garcia
Subjects: Gynecology, Waist-to-height ratio, medicine.medical_specialty, Índice de massa corporal, business.industry, lcsh:Public aspects of medicine, Health Policy, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Anthropometry, Gordura abdominal, medicine, Abdominal fat, Desordem cognitiva, business, Antropometria
Abstract: Resumo O objetivo deste artigo é investigar a associação entre demência e indicadores antropométricos em idosos de Florianópolis. Estudo transversal, de base populacional, realizado com 1.197 idosos (≥ 60 anos) em 2013/2014. A demência foi considerada como a presença conjunta de escore baixo no Miniexame do Estado Mental (MEEM) e a incapacidade funcional moderada/grave nas atividades de vida diária (AVD). As variáveis independentes avaliadas foram: índice de massa corporal (IMC), perímetro da cintura (PC), índice de conicidade e relação cintura/estatura (RCEst). A regressão logística (bruta e ajustada) foi utilizada para identificar os fatores associados. A prevalência estimada de demência foi de 15,1%. Após ajustes para características sociodemográficas, estilo de vida e sintomas depressivos, a demência foi positivamente associada aos tercis superiores do IMC (OR: 2,32; IC95%: 1,26-4,25), PC (OR: 2,22; IC95%: 1,20-4,11) e RCEst. (OR: 2,30; IC95%: 1,19-4,43). De acordo com os resultados, tanto a obesidade quanto a gordura abdominal foram associados ao desfecho, sugerindo que o IMC, o PC e a RCEst. devam ser considerados na investigação dessa relação.
Published: 2019

88. Tooth Loss and Allostatic Load Changes Later in Life: A 12-Year Follow-Up Analysis of the English Longitudinal Study of Ageing (ELSA)

Author: Cesar de Oliveira, Wael Sabah, Ione Jayce Ceola Schneider, and Eduardo Bernabe
Published: 2019

89. Incidência e mortalidade por COVID-19 nos municípios de Santa Catarina: associação com indicadores sociodemográficos

Author: Ione Jayce Ceola Schneider, Maruí Weber Corseuil Giehl, Sabrina Leal Pscheidt, Edson da Silva Santos, and Roger Flores Ceccon
Subjects: Coronavirus disease 2019 (COVID-19), 0211 other engineering and technologies, 02 engineering and technology, Biology, lcsh:Social Sciences, Ecological Studies, Estudios ecologicos, 03 medical and health sciences, 0302 clinical medicine, Indicadores sociais, Incidência, 030212 general & internal medicine, Mortality, lcsh:Science (General), General Environmental Science, lcsh:LC8-6691, 021110 strategic, defence & security studies, lcsh:Special aspects of education, Incidence, Social indicators, COVID-19, Estudos ecológicos, lcsh:H, Indicadores sociales, Mortalidad, Mortalidade, General Earth and Planetary Sciences, Incidencia, Humanities, lcsh:Q1-390
Abstract: Objective: To analyze Covid-19 incidence and mortality and its relationship with social indicators of the municipalities of Santa Catarina. Methods: An ecological study with data from the 1st to 14th epidemiological weeks in the year 2020. The independent variables were sociodemographic indicators. The outcomes were the incidence and mortality rates for Covid-19 for each municipality. Negative inflated zero binomial regression was used, considering 95% confidence intervals and thematic maps were created. Results: In the period, 17,368 cases and 253 deaths were recorded. The incidence of Covid-19 was associated with greater population size, demographic density, and Gini index, and decreased with increasing aging rates. Mortality, on the other hand, was associated with an increase in population size and demographic density. Conclusion: Although Covid-19 has potential for dissemination to all municipalities in Santa Catarina, social and demographic characteristics are related to pandemic behavior. Objetivo: analizar la relación entre incidencia y mortalidad por Covid-19 con indicadores sociodemográficos en los municipios de Santa Catarina. Métodos: estudio ecológico con datos de la 1ª a la 14ª semana epidemiológica del año 2020. Las variables independientes fueron indicadores sociodemográficos y los resultados fueron las tasas de incidencia y mortalidad debidas a Covid-19. Se utilizó una regresión binomial negativa inflada de ceros, con los respectivos intervalos de confianza del 95% y se elaboraron mapas temáticos. Resultados: en el período, se registraron 17.368 casos y 253 muertes. La incidencia de Covid-19 se asoció con un mayor tamaño de la población y la densidad demográfica y el índice Gini y disminuyó con el aumento de las tasas de envejecimiento. La mortalidad se asoció con un aumento en el tamaño de la población y la densidad demográfica. Conclusión: Aunque Covid-19 tiene potencial de difusión a todos los municipios del estado de Santa Catarina, las características sociales y demográficas están relacionadas con el comportamiento de la pandemia. Objetivo: Analisar a relação entre incidência e mortalidade por Covid-19 com os indicadores sociodemográficos nos municípios de Santa Catarina. Métodos: estudo ecológico com dados da 1ª a 14ª semana epidemiológica do ano de 2020. As variáveis independentes foram indicadores sociodemográficos e os desfechos foram as taxas de incidência e de mortalidade por Covid-19. Foi utilizada a regressão binomial negativa inflada de zeros, com os respectivos intervalos de confiança de 95% e elaborados mapas temáticos. Resultados: No período foram registrados 17.368 casos e 253 óbitos. A incidência da Covid-19 foi associada com maior porte populacional e densidade demográfica e índice de Gini e reduziu com aumento taxas de envelhecimento. A mortalidade associou-se ao aumento do porte populacional e densidade demográfica. Conclusão: Embora a Covid-19 apresente potencial de disseminação para todos os municípios do estado de Santa Catarina, as características sociais e demográficas estão relacionados ao comportamento da pandemia.
Published: 2020

90. Anthropometric measures change and quality of life in elderly people: a longitudinal population-based study in Southern Brazil

Author: Maruí Weber Corseuil Giehl, Ana Aparecida Tessari, Ione Jayce Ceola Schneider, and David Alejandro González-Chica
Subjects: Male, Aging, Waist, Population, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Humans, Medicine, Longitudinal Studies, 030212 general & internal medicine, education, Aged, Aged, 80 and over, education.field_of_study, 030505 public health, Anthropometry, business.industry, Confounding, Public Health, Environmental and Occupational Health, Middle Aged, humanities, Quartile, Quality of Life, Female, 0305 other medical science, business, Body mass index, Brazil, Demography, Cohort study
Abstract: To analyze the effects of anthropometric measures change on quality of life (QoL) in elderly, using measured anthropometric data on body mass index (BMI) and waist circumference (WC). Population-based cohort study investigating a sample of elderly (≥60) assessed in 2009 (n = 1705) and followed up in 2013 (n = 1197). QoL was evaluated in 2013 using the CASP-19. Variables evaluated as exposure including BMI and WC in 2009 (both standardized), categories of anthropometric measures change from 2009 to 2013 (excess weight = BMI ≥ 25.0 kg/m2; large WC = top quartile), and the absolute BMI and WC change in same period. Multivariate linear regressions adjusted for possible confounding factors and mediators were used. Both BMI and WC at baseline were associated with lower QoL scores, even after adjustment for confounding variables (β BMI = −0.9; 95 % CI −1.5; −0.3 and β WC = −1.0; 95 % CI −1.7; −0.4). Additionally, QoL scores were lower among elderly with excess weight (β = −1.4; 95 % CI −2.9; 0.0) or large WC (β = −3.3; 95 % CI −5.2; −1.4) in both waves than among those whose BMI and WC were always normal, but changes in anthropometric measures did not affect QoL. The presence of chronic diseases was a partial mediator of these associations, especially for effects of BMI change. Anthropometric measures change treated as a continuous variable was not associated with QoL. Having excess weight and large WC in both waves was associated with lower QoL scores in elderly, but changing the anthropometric measures did not affect this outcome. Maintaining weight and WC within normal limits during aging can help to preserve QoL.
Published: 2016

91. Built Environment and Walking Behavior Among Brazilian Older Adults: A Population-Based Study

Author: Maruí Weber Corseuil Giehl, Pedro C. Hallal, Claudia Weber Corseuil, Eleonora d'Orsi, and Ione Jayce Ceola Schneider
Subjects: Male, Population, Poison control, Walking, Suicide prevention, Occupational safety and health, 03 medical and health sciences, 0302 clinical medicine, Injury prevention, Humans, Medicine, Orthopedics and Sports Medicine, 030212 general & internal medicine, education, Exercise, Built environment, Aged, Aged, 80 and over, education.field_of_study, 030505 public health, business.industry, Odds ratio, Middle Aged, Confidence interval, Female, 0305 other medical science, business, Brazil, Demography
Abstract: Background:Understanding the built environment influence on specific domains of walking is important for public health interventions to increase physical activity levels among older adults.Purpose:The purpose was to investigate the association between built environment characteristics and walking among older adults.Methods:A population-based study was performed in 80 census tracts in Florianópolis, Brazil, including 1,705 older adults (60+ years old). Walking was measured using the International Physical Activity Questionnaire. Built environment characteristics were assessed through a geographic information system. All analyses were conducted through a multilevel logistic regression.Results:Individuals living in neighborhoods with a higher population density (odds ratio [OR]: 2.19; 95% confidence interval [CI], 1.40–3.42), with a higher street connectivity (OR: 1.85; 95% CI, 1.16–2.94), a higher sidewalk proportion (OR: 1.77; 95% CI, 1.11–2.83), and paved streets (medium tertile: OR: 1.61, 95% CI, 1.04–2.49; highest tertile: OR: 2.11; 95% CI, 1.36–3.27) were more likely to walk for transportation. Regarding walking for leisure, only 2 predictors were associated, area income (OR: 1.48; 95% CI, 1.04–2.12) and street density (OR: 1.47; 95% CI, 1.02–2.10).Conclusions:Improving the neighborhood built environment is an important step for achieving higher levels of walking in the elderly population in a middle-income country.
Published: 2016

92. The burden of infectious diseases in the Brazilian Southern state of Santa Catarina

Author: Daniela Alba Nickel, Eliane Traebert, Jefferson Traebert, Ione Jayce Ceola Schneider, and Juan Jc Escalante
Subjects: Male, Gerontology, Human immunodeficiency virus (HIV), medicine.disease_cause, 0302 clinical medicine, Prevalence, Measurements in epidemiology, 030212 general & internal medicine, Child, Aged, 80 and over, education.field_of_study, Geography, lcsh:Public aspects of medicine, Age Factors, Burden of disease, General Medicine, Hepatitis C, Middle Aged, Hepatitis B, Child, Preschool, Infectious diseases, Female, Brazil, Adult, Tuberculosis, Adolescent, Basic indicados for health, 030231 tropical medicine, Population, Infectious dissesses, Communicable Diseases, lcsh:Infectious and parasitic diseases, Young Adult, 03 medical and health sciences, Sex Factors, Acquired immunodeficiency syndrome (AIDS), Environmental health, medicine, Humans, lcsh:RC109-216, education, Aged, business.industry, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, Ecological study, lcsh:RA1-1270, medicine.disease, Survival Analysis, Epidemiologic Studies, Years of potential life lost, Basic indicators for health, business
Abstract: Summary: Infectious diseases are still significant causes of deaths in Brazil. The objective of this study was to estimate the burden of selected infectious diseases in the Brazilian Southern state of Santa Catarina in 2011. An ecological study was conducted. The infectious diseases included were HIV/AIDS, tuberculosis, hepatitis B, hepatitis C, Chagas disease, diarrheal diseases and other infectious diseases. Data were collected from official health information systems. Disability Adjusted Life Years (DALY) were estimated by the sum of Years of Life Lost (YLL) and Years Lived with Disability (YLD). 45,237.33 DALYs were estimated, with a rate of 685.46 DALYs per 100,000 population. 92.9% was due to YLL and 7.1% to YLD. Men and the age range of 0–4 years presented higher burden. The highest burden was attributed to HIV/AIDS. There was a high concentration of burden rates in the coast regions of the state. It could be concluded that more than 90% of the burden was attributed to the early mortality component. The highest burden was observed among men, children under 5 years of age and at the coast regions of the state. The highest levels of burden were due to HIV/AIDS. Keywords: Measurements in epidemiology, Infectious diseases, Basic indicators for health, Burden of disease
Published: 2016

93. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013

Author: Yong Zhao, Hadi Danawi, Bach Xuan Tran, Gene Bukhman, Vasiliki Stathopoulou, Taavi Tillmann, Nelson Alvis-Guzman, Yongmei Li, Jerry Puthenpurakal Abraham, Sudan Prasad Neupane, Jack Caravanos, Ben Schöttker, Rafael Lozano, Damian G Hoy, Yoshihiro Kokubo, Nicholas J K Breitborde, Sergey Soshnikov, Yukito Shinohara, Randall V. Martin, Michael Brainin, Fernando Perez-Ruiz, Yingfeng Zheng, Santosh Mishra, Julio Cesar Montañez Hernandez, Michael Phillips, Belinda J. Gabbe, Hebe N. Gouda, Ziad A. Memish, Rupert R A Bourne, Guoqing Hu, Emmanuel A. Ameh, Abigail McLain, Michelle L. Bell, Christopher Margono, Marissa Iannarone, Wilkister N. Moturi, Donald H. Silberberg, Carl Abelardo T. Antonio, Nataliya Foigt, Anand Dayama, Yanping Wang, Amanda J. Mason-Jones, Bolajoko O. Olusanya, Monica S. Vavilala, Katherine B Gibney, David Tanne, Sidibe S Kany Roseline, Marcella Montico, Abhishek Singh, Sarah Derrett, Alireza Esteghamati, Seok Jun Yoon, Corine Karema, Rakhi Dandona, David M. Pereira, Kazem Rahimi, Gitanjali M. Singh, Vivekanand Jha, John Hornberger, Anne M. Riederer, Kathryn H. Jacobsen, Andrea Pedroza, Lily Alexander, Fiona M. Blyth, Tommi Vasankari, Kyle J Foreman, Rana J. Asghar, Tilahun Nigatu Haregu, Yousef Khader, Rafael Alfonso-Cristancho, Suzanne Barker-Collo, Lydia S. Atkins, Simerjot K. Jassal, Mohammad Ali Sahraian, Peter Scarborough, Hans W. Hoek, E. Ray Dorsey, Muluken Dessalegn, David C. Schwebel, Gavin Shaddick, Thomas D. Fleming, Mohammad Tavakkoli, Dorairaj Prabhakaran, Mohammad H. Forouzanfar, Christopher C. Mapoma, Jost B. Jonas, Erin C Mullany, Gene F. Kwan, Johanna M. Geleijnse, Antonio Luiz Pinho Ribeiro, Roberto Tchio Talongwa, Tolesa Bekele, Jed D. Blore, Gunn Marit Aasvang, Philimon Gona, Miguel Angel Alegretti, Babak Eshrati, Mitsuru Mukaigawara, Richard F. Gillum, Odgerel Chimed-Ochir, Ubai Alsharif, Richard C. Franklin, Felix Masiye, Richard T. Burnett, Sanjay Krishnaswami, Martin McKee, John J Huang, Lucía Cuevas-Nasu, Wagner Marcenes, Walid Ammar, Knud Juel, Joseph R. Zunt, Martha M Téllez Rojo, Mamta Swaroop, Noela M Prasad, Azmeraw T. Amare, Tim Driscoll, Michael Kravchenko, Heresh Amini, Amir Sapkota, Theo Vos, Charlotte Watts, Dennis Odai Laryea, D. Alex Quistberg, Justin Beardsley, Cheng Huang, Adnan M. Durrani, Sarah V Thackway, Rita Van Dingenen, Manami Inoue, Martha Híjar, Honglei Chen, Amany H. Refaat, Yichong Li, Vineet K. Chadha, Wenzhi Wang, Louisa Degenhardt, Kingsley N. Ukwaja, Nayu Ikeda, James D. Wilkinson, Linh N Bui, Maria Hagströmer, Gonghuan Yang, Ann Kristin Knudsen, David J. Margolis, Soewarta Kosen, Hans Kromhout, Atsushi Goto, Man Mohan Mehndiratta, Thomas N. Williams, Michael Soljak, Yun Jin Kim, Hideaki Toyoshima, Jeyaraj D Pandian, Borja del Pozo-Cruz, Soufiane Boufous, Ivy Shiue, Anders Larsson, Guilherme V. Polanczyk, John Powles, Yara A. Halasa, Robin Room, Ratilal Lalloo, Carolina Batis Ruvalcaba, Panniyammakal Jeemon, Elisabete Weiderpass, Jürgen Rehm, Ejaz Ahmad Khan, Alicia Aleman, Zacharie Tsala Dimbuene, Elena Alvarez, Rachelle Buchbinder, Randah R. Hamadeh, Bryan Hubbell, Sadaf G. Sepanlou, Farhad Islami, Costas A. Christophi, Heidi Stöckl, Ismael R. Campos-Nonato, Nigel Bruce, Edward J Mills, Samuel A L Perry, Taavi Lai, Baffour Awuah, Mete Saylan, Karen J. Courville, Arindam Basu, Vanessa De la Cruz-Góngora, Teresita González de Cosío, Naohiro Yonemoto, Frida Namnyak Ngalesoni, Muluken Azage Yenesew, Atte Meretoja, Michael Brauer, Cyrus Cooper, Giorgia Giussani, Valentina S. Arsic Arsenijevic, Vasiliy Victorovich Vlassov, André Karch, Leilei Duan, Matthew M Coates, Omid Ameli, Gelin Xu, Matthias Endres, Ganesan Karthikeyan, Ione Jayce Ceola Schneider, Mohamed Hsairi, Palwasha Anwari, Mazin J. Al Khabouri, Dariush Mozaffarian, Juan R. Sanabria, Pablo M. Lavados, Sumeet S. Chugh, Johan Ärnlöv, Ivo Rakovac, Maurice Giroud, Haidong Kan, Ibrahim Abdelmageem Mohamed Ginawi, José Luis Texcalac-Sangrador, Luigi Naldi, Erica Leigh Slepak, Deena Alasfoor, James E. Saunders, Richard Matzopoulos, Talal Bakfalouni, Stein Emil Vollset, Andrea Werdecker, Lennert J. Veerman, Lorenzo Monasta, Henrica A. F. M. Jansen, Reyna A Gutiérrez, Brittany Wurtz, Luz Maria Sanchez, Lijing L. Yan, M. Patrice Lindsay, Michele Meltzer, Sanjay Basu, Steven van de Vijver, Alaa Badawi, Thomas Claßen, Young-Ho Khang, Brett M. Kissela, Jun Zhu, In-Hwan Oh, Fiona J Charlson, Maria Cecilia Bahit, Dinorah González-Castell, Rosario Cárdenas, Dan Poenaru, Sayed Saidul Alam, Mitchell T. Wallin, Harish Chander Gugnani, James Leigh, Ferrán Catalá-López, Lidia Morawska, Jim van Os, Stephanie J. London, Kaire Innos, Isabelle Romieu, Fiorella Cavalleri, Adrian Davis, Hwee Pin Phua, Chakib Nejjari, Héctor Gómez Dantés, Boris I. Pavlin, Karen Sliwa, Lynne Gaffikin, Constance D. Pond, Michael F. MacIntyre, Blake Thomson, Norberto Perico, Ronny Westerman, Samantha M. Colquhoun, Michael H. Criqui, Ana Maria Nogales Vasconcelos, Wubegzier Mekonnen, Bulat Idrisov, Ana Basto-Abreu, Andrew G. M. Bulloch, Jasvinder A. Singh, Vinod K. Paul, Emin Murat Tuzcu, Svetlana Popova, Hmwe H Kyu, Richard L. Guerrant, Mohammed I. Albittar, Srikanth Mangalam, Steven E. Lipshultz, Lela Sturua, Semaw Ferede Abera, Eduardo Bernabé, George D. Thurston, Bruno F. Sunguya, Tiffany Ku, Alejandra G. Contreras, Abdullah Sulieman Terkawi, Charles Atkinson, Ashkan Afshin, Heidi J. Larson, Abdullatif Husseini, Jose C. Adsuar, Reza Assadi, Ademola Lukman Adelekan, Joshua A. Salomon, Yousef M. Elshrek, Gokalp Kadri Yentur, Devina Nand, Narayanaswamy Venketasubramanian, Graça Maria Ferreira De Lima, Maheswar Satpathy, Fotis Topouzis, Traolach S. Brugha, Hywel C Williams, Coen H. Van Gool, Andrew H. Kemp, Awoke Misganaw, Amado D Quezada, Norito Kawakami, Bert Brunekreef, Peter Burney, Tati S. Warouw, Jongmin Lee, Inga Dora Sigfusdottir, Marcel Tanner, Solveig A. Cunningham, Benjamin O. Anderson, Tariku Jibat Beyene, Lars Barregard, Xia Wan, Giuseppe Remuzzi, Bernadette Thomas, Lilia S Pedraza, Massimo Cirillo, Alina Rodriguez, Ricky Leung, Farshad Pourmalek, K. Srinath Reddy, Charles D.A. Wolfe, Ulrich O Mueller, Neeraj Bedi, Al Artaman, Lucia Hernandez, Itamar S. Santos, C. Arden Pope, Norlinah Mohamed Ibrahim, Carlo Irwin A. Panelo, Selen Begüm Uzun, Miltiadis K. Tsilimbaris, Anwar Rafay, Daniel Dicker, Melvin Barrientos Marzan, Sajjad Ur Rahman, Mohammed O. Basulaiman, Edgar P. Simard, Mohammad T Mashal, Maysaa El Sayed Zaki, Shiwei Liu, Don C. Des Jarlais, Bo Norrving, Salvador Villalpando, Miia Kivipelto, Yang Liu, Carolina Maria Teixeira, Catalina Medina, Sudha Jayaraman, Josep Maria Haro, Diego De Leo, Angel J Paternina Caicedo, Abigail C. McKay, Eric L. Ding, Mukesh Dherani, Ljiljana Pejin Stokic, Vinay Nangia, Sukanta Saha, Juan Liang, Elisabeth Cardis, Zourkaleini Younoussi, José R Nogueira, Braden Te Ao, Vasco Manuel Pedro Machado, Lionel Racapé, Ting Wu Chuang, Shahab Khatibzadeh, E Filipa de Castro, Barthelemy Kuate Defo, Ulises Trujillo, Alan D. Lopez, Soraya Seedat, Lope H Barrero, Linhong Wang, Daniel Pope, Alexandra Brazinova, Faris Lami, Valentina Colistro, G Anil Kumar, Derek F J Fay, Haidong Wang, Hwashin H. Shin, Raimundas Lunevicius, Suzanne Polinder, Dietrich Plass, David Rojas-Rueda, Stephen S Lim, Tania G Sánchez-Pimienta, K.M. Venkat Narayan, Yuantao Hao, Jung-Chen Chang, Corina Benjet, Seyed-Mohammad Fereshtehnejad, Luciano A. Sposato, Stan Biryukov, Kunihiro Matsushita, Beth E. Ebel, Cleusa P. Ferri, Soumya Swaminathan, K. Ryan Wessells, Gustavo Velasquez-Melendez, Leslie T. Cooper, David O. Carpenter, Nancy Lopez, Bryan L. Sykes, Sandra Nolte, Murray B. Stein, Paul N. Jensen, Fabiola Mejía-Rodríguez, Xiaonong Zou, Bradford D. Gessner, Dhruv S. Kazi, Dragos Virgil Davitoiu, Alejandra Jáuregui, Pouria Heydarpour, Megan Bohensky, Harvey Whiteford, Berrak Bora Basara, Zhengming Chen, Gregory R. Wagner, Paul I. Dargan, Hermann Brenner, Nima Hafezi-Nejad, John Nelson Opio, Scott Weichenthal, Deborah Salvo, Jun She, Tea Lallukka, Carolyn C. Gotay, Stephen G. Waller, Christian Kieling, Shivanthi Balalla, Valery L. Feigin, Qing Lan, Matias Trillini, Adam D M Briggs, Sungroul Kim, Niveen M E Abu-Rmeileh, Renata Micha, Sergey Petrovich Ermakov, Ole Frithjof Norheim, Zulfiqar A Bhutta, Paul S. F. Yip, Grant Nguyen, Ralph L. Sacco, Biju Abraham, Ken Takahashi, Jixiang Ma, Peter A. Meaney, Ayse Abbasoglu Ozgoren, Kimberly Cooperrider, M Rifat Kose, Shams Eldin Ali Hassan Khalifa, Rasmus Havmoeller, Alize J. Ferrari, Kebede Deribe, Nadim E. Karam, George A. Mensah, Bongani M. Mayosi, Konrad Pesudovs, Joanna Moschandreas, Ziad Nahas, James Damsere-Derry, Nsanzimana Sabin, Tonatiuh Barrientos-Gutiérrez, Ying Jiang, Andre Pascal Kengne, Peter Allebeck, Jonas Minet Kinge, Shankuan Zhu, Guy B. Marks, Daniel C Casey, Marco A Avila, Anna Roca, Lalit Dandona, Ami R. Moore, Adansi A. Amankwaa, David Gunnell, Andre Keren, Yohannes Adama Melaku, Nhung T Nguyen, Anthony D. Woolf, Mayuree Rao, Peter J. Allen, Christina Papachristou, Karzan Abdulmuhsin Mohammad, Ravi Kumar Balu, Marie Ng, Marcello Tonelli, Maziar Moradi-Lakeh, Maigeng Zhou, Emmanuela Gakidou, Mohammed K. Ali, Amanda W Pain, Dan J. Stein, Kawkab Shishani, Fortuné Gbètoho Gankpé, Howard J. Hoffman, James Scott, Nadine Steckling, Samia Alhabib, Deborah Jarvis, Kara Estep, Arsène Kouablan Adou, Ricardo Orozco, Holly Hagan, K. C. Astha, Reza Malekzadeh, Klara Dokova, Aliya Naheed, Ernst J. Kuipers, Valeria Caso, Derrick A Bennett, Andrea B. Feigl, Uche S. Uchendu, Holly E. Erskine, Shireen Sindi, Arjun Lakshmana Balaji, Francesco Saverio Violante, Monika Sawhney, Alejandra Cantoral, Ketevan Goginashvili, Raghib Ali, Fan Jiang, Robert G. Weintraub, Homie Razavi, Myriam Tobollik, Howard Hu, Emerito Jose A. Faraon, Irma Khonelidze, Patricia M. Riccio, Eun-Kee Park, Julio Cesar Campuzano, Ibrahim Abubakar, Jürgen C Schmidt, Konstantinos Stroumpoulis, Aref A. Bin Abdulhak, Graeme J. Hankey, Natan M. Bornstein, Mouhanad Hammami, Lee Richardson, Rintaro Mori, Alanur Çavlin, Ruth W Kimokoti, Samir Soneji, Mark J. Nieuwenhuijsen, John Q. Wong, Joseph Frostad, Tom Achoki, Rahman Shiri, Ashish Bhalla, Kurt Straif, Simon I. Hay, Scott B. Patten, Kalpana Balakrishnan, Awoke Misganaw Temesgen, Chandrashekhar T Sreeramareddy, Ryan M Barber, Rosana E. Norman, JianLi Wang, Siyi Shangguan, Luke Nyakarahuka, Kovin Naidoo, Charles D. H. Parry, Mercedes Colomar, H. Ross Anderson, Carlos Magis-Rodriguez, Joan M. Nolla, Muhammad Imran Nisar, Karen Devries, Andrew L. Thorne-Lyman, Denis Nash, Marape Marape, Rajiv Chowdhury, Dima M. Qato, Luca Ronfani, Nobhojit Roy, Daniel Kim, Yuichiro Yano, Luke D. Knibbs, Margaret Robinson, Hilda L Harb, Rogelio Pérez-Padilla, Janet L Leasher, Jonathan L. Wright, Peter Brooks, Cristiana Abbafati, Belinda K Lloyd, Victor Aboyans, Nikhil Tandon, Charles R. Newton, Simón Barquera, Ted R. Miller, Kinnari S. Murthy, Habib Benzian, Glen Mola, Paulo A. Lotufo, Burcu Kucuk Bicer, Peggy Pei-Chia Chiang, Alexander Kraemer, Solomon Meseret Woldeyohannes, Saman Fahimi, Lesley Rushton, Kim Moesgaard Iburg, Vafa Rahimi-Movaghar, Logan Sandar, Bruce Neal, Teresa Shamah Levy, Karen M. Tabb, Jeffrey A. Towbin, Christopher J L Murray, Ramesh Sahathevan, Aaron Cohen, Chanda Kulkarni, Van C. Lansingh, François Alla, Tasara T. Mazorodze, Murugesan Raju, Saeid Shahraz, Uchechukwu K.A. Sampson, Rajeev Gupta, Neil Pearce, Mustafa Z. Younis, Veena S. Kulkarni, Francisco A García-Guerra, Amanda G. Thrift, Stefan Ma, Samaya Ismayilova, Evariste Gasana, Amitava Banerjee, Aslam Pervaiz, Emilie Agardh, Abraham D. Flaxman, Farshad Farzadfar, Peter W. Gething, Ileana Heredia-Pi, Boris Bikbov, Wanqing Chen, Saad B. Omer, Ruben Castro, Neeraj Bhala, Sara Sheikhbahaei, Hilton Lam, Urbano Fra Paleo, Lidia Sanchez-Riera, Alicia Elena Beatriz Lawrynowicz, Kristen Delwiche, Richard G. Ellenbogen, Max Petzold, Yuri Y Varakin, Guilherme Borges, Guohong Jiang, Francis Guillemin, Kyle R. Heuton, Yohannes Kinfu, Victoria F Bachman, Joseph A Wagner, Carlos A Castañeda-Orjuela, Leonardo Trasande, Abbas Ali Mahdi, Josef Coresh, Chuanhua Yu, Kenji Shibuya, Berrin Serdar, Laetitia Huiart, Xiaofeng Liang, Jean de Dieu Ngirabega, Takayoshi Ohkubo, Natalie Stephens, Francis Apolinary Mhimbira, Jefferson Traebert, Amiran Gamkrelidze, Kjetil Søreide, Samath D Dharmaratne, Robert P. Dellavalle, George Mugambage Ruhago, Lakshmi Vijayakumar, Joannie Lortet-Tieulent, Dipan Bose, Tania C Aburto, Saleem M Rana, Miriam Levi, Mohammad Taghi Hedayati, Rodolfo S Pagcatipunan, Ron T. Gansevoort, H. D. Hosgood, Michael Burch, Mohsen Naghavi, Vegard Skirbekk, Ayfer Pekericli, Walter Mendoza, Pengpeng Ye, Gabrielle deVeber, Ali H. Mokdad, David M. Broday, Koranteng Adofo, Zewdie Aderaw Alemu, Shifalika Goenka, Carrie Beth Peterson, Nicolas J. C. Stapelberg, Edson Serván-Mori, Anil Kaul, Foad Abd-Allah, Marek Majdan, Rahul Gupta, Giancarlo Logroscino, Kardiyoloji, Peterson, Carrie B., Laboratoire de Physique des Solides (LPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Wisconsin Division of Public Health, Laboratoire de psychologie sociale et de psychologie cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Erosion torrentielle neige et avalanches (UR ETGR (ETNA)), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), London South Bank University, Metropolitan Police Service, Hong Kong Baptist University (HKBU), Institut für Informatik [München/Munich] (LMU), Ludwig-Maximilians-Universität München (LMU), Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Insight Centre for Data Analytics [Galway] (INSIGHT), National University of Ireland [Galway] (NUI Galway), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Karolinska Institute, karolinska institute, Department of Molecular Biosciences, Department of Molecular Biosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Centro de Estudios Avanzados en Zonas Aridas (CEAZA), Ecole Polytechnique Fédérale de Lausanne (EPFL), Regional Genetic Service, St Mary's Hospital, Manchester, Laboratoire d'Ingénierie des Matériaux (LIM), Centre National de la Recherche Scientifique (CNRS), Computer Science Department [Bristol], University of Bristol [Bristol], Universität Mannheim [Mannheim], Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) (SRI-B), Computational Science and Engineering Department [Daresbury] (STFC), Science & Technologie Facilities Council, Multimedia Research Center (MRC), University of Alberta, Division of Biostatistics (Biostat - MINNEAPOLIS), University of Minnesota [Twin Cities], University of Minnesota System-University of Minnesota System, University of Southampton, Imperial College London, Neurology Department, Ichilov Medical Center, Interactions, transferts, ruptures artistiques et culturels - EA 6301 (InTRu), Université de Tours, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Risk Assessment Sciences Institute, Utrecht University [Utrecht], Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Respiratory Epidemiology and Public Health, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], CIBER de Epidemiología y Salud Pública (CIBERESP), STAR laboratory, Stanford University [Stanford], Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), Tennent Institute of Ophthalmology, National University of Singapore (NUS), Centre de Robotique (CAOR), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Multidisciplinary Nanotechnology Centre, Swansea University, Cyprus International Institute for the Environment and Public Health, Harvard School of Public Health, Genomics Research Center, Academia Sinica, Neuro Rehab Services LLP [New Delhi], Department of Signal Theory and Communications (TSC), Univ. Politec. de Catalunya, King‘s College London, Dept. Mat. Engn. De Ma, Sao Carlos, Fed. Univ. Sao Carlos UFSCar, RESPEC (RESPEC), RESPEC, Advanced Laboratories on Embedded Systems [Roma] (ALES), Department of Biology [Miami], University of Miami [Coral Gables], Health Care, Minister Of Labour-Ministry of Labor, Health and Social Affairs, Department of Nephrology, University Medical Center, University of Groningen, Division of Human Nutrition, Wageningen University and Research Centre [Wageningen] (WUR), Spatial Ecology and Epidemiology Group, University of Oxford [Oxford], College of Medicine, University of Hail, Saudi Arabia, Laboratory of Neurologic Diseases, Mario Negri Institute, Milan, Department of Civil Engineering [Hamirpur], National Institute of Technology [Hamirpur], GEMMA — Environmental Engineering and Microbiology Research Group, Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya [Barcelona] (UPC), Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Institut National de Recherche et d'Analyse Physico-chimique (Ariana, Tunisie) (INRAP), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences [Tehran] (SBUMS), Shahid Beheshti University-Shahid Beheshti University, Center for Applied Medical Research (CIMA), University of Tehran, Secretariat of the Pacific Community, Public Health Division, Sociétés, Acteurs, Gouvernement en Europe (SAGE), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), College of Precision Instrument and Optoelectronics Engineering, Tianjin University, George Washington University (GW), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universiteit Gent [Ghent], Washington State University (WSU), Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, School of Computer Science - China University of Geosciences (China University of Geosciences (East Area)), Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Catholique de Louvain (UCL), Fachbereich Physik [Berlin], Freie Universität Berlin, Div Cyclotron & Radiopharmaceut Sci (DRDO, INMAS), Univ New Delhi, School of Physics and Astronomy, University of St Andrews [Scotland], University of Cape Town, Department of Neuroscience, Department of Computer Science and Engineering [Daejeon] (Chungnam National University), Lawrence University, Gastroenterology & Hepatology, Tata Research Development and Design Center (TRDDC), TCS Innovation Labs, University of Helsinki, Google Inc [Mountain View], Research at Google, Swedish Defense Research Agency (FOI), Servicio de Neurologia (SANTIAGO - Neurologie), Universidad del Desarrollo, Novartis Pharmaceutical Corporation, Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Observatoire des Sciences de l'Univers de Grenoble [1985-2015] (OSUG [1985-2015]), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Department of Mechanical and Automation Engineering (CAD Laboratory), The Chinese University of Hong Kong [Hong Kong], Università degli studi di Bari, Department of Health and Human Services, National Institutes of Health [Bethesda] (NIH), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Heuristique et Diagnostic des Systèmes Complexes [Compiègne] (Heudiasyc), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), College of Information and Electrical Engineering [Beijing] (CIEE), China Agricultural University (CAU), Thales Research and Technology [Palaiseau], THALES, Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (QMUL), Centre d'économie de la Sorbonne (CES), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), École supérieure du professorat et de l'éducation - Académie de Grenoble [2013-2019] (ESPE Grenoble [2013-2019]), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Department of Mathematics, University of Iowa [Iowa City], College of Medicine, Alfaisal University, Saudi Ministry of Health, Institut national des recherches agricoles du Bénin, Centre de Recherches agricoles du Sud, Departments of Epidemiology and Nutrition, Unit of Human Nutrition, Agricultural University of Athens, Department of Animal Science, Pennsylvania State University (Penn State), Penn State System-Penn State System, University of Virginia, University of Virginia [Charlottesville], Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health - IRCCS ‘‘Burlo Garofolo', Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Division of Cardiovascular Medicine and Channing Division of Network Medicine, Brigham and Women's Hospital [Boston], American University of Beirut [Beyrouth] (AUB), Department of Chemistry, Scientific Computing Research Unit, Department of dermatology, Milano University-Azienda Ospedaleria Ospedali Riuniti di Bergamo, Mailman School of Public Health, Columbia University [New York], The Georges Institute for International Health, The University of Sydney, Department of epidemiology and Public Health, Faculty of Medicine, Département Optique (OPT), Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT), Laboratoire des signaux et systèmes (L2S), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Universitat Pompeu Fabra [Barcelona], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Nutriments Lipidiques et Prévention des Maladies Métaboliques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université de la Méditerranée - Aix-Marseille 2, Department of Neurology Lunds University Hospital Lund, Unit of Functional Bionanomaterials, School of Biosciences, University of Birmingham [Birmingham], Electrical Engineering and Computer Science Department - Case Western Reserve University, Case Western Reserve University [Cleveland], World Health Organization, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Nordic School of Public Health, The James Hutton Institute, Horia Hulubei National Institute for Physics and Nuclear Engineering, Department of Pediatrics, University of Washington [Seattle], Institute of Public Health, Department of Physics, Clarendon Laboratory, Center for TeleInFrastruktur (CTIF), Aalborg University [Denmark] (AAU), Physikalisches Institut [Freiburg], Albert-Ludwigs-Universität Freiburg, Savoirs, Textes, Langage (STL) - UMR 8163 (STL), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Dept.of Computer Science, Indian Institute of Technology Madras (IIT Madras), Istituto Mario Negri Bergamo, Centro Ricerche e Trapianti Villa Camozzi, Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut geològic de Catalunya (IGC), Institut Geològic de Catalunya-IGC, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Recherche Agronomique (INRA), Politecnico di Milano [Milan] (POLIMI), Symantec, University of Oviedo, European Microsoft Innovation Center (EMIC), Microsoft Corporation [Redmond, Wash.], Technion - Israel Institute of Technology [Haifa], Laboratoire de Mécanique, Physique et Géosciences (LMPG), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU), Department of Physics, Cavendish Laboratory, University of Cambridge [UK] (CAM), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Departments of Applied Physics [New Haven], Yale University [New Haven], Center for Mathematical Modeling (CMM), Department of Global Health and Development, London School of Hygiene and Tropical Medicine (LSHTM), University of Occupational and Environmental Health [Kitakyushu] (UEOH), Department of Computer Science and Engineering [New Delhi], Indian Institute of Technology Delhi (IIT Delhi), Institut de Recherche sur les Phénomènes Hors Equilibre (IRPHE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), GlaxoSmithKline, Imperial College London-Clinical Imaging Center, Universidade Federal de Pernambuco [Recife] (UFPE), Maclean Building, Benson Lane, Crowmarsh Gifford, Centre for Ecology and Hydrology, Nanoscience Institute (NEST), Dipartimento di Fisica, Università di Pisa, Aristotle University of Thessaloniki, Laboratory Of Immune Cell Biology (LICB), JRC Institute for Environment and Sustainability (IES), European Commission - Joint Research Centre [Ispra] (JRC), Institute of Human Genetics, Rheinische Friedrich-Wilhelms-Universität Bonn, Laboratorio Nacional de Computação Cientifica [Rio de Janeiro] (LNCC / MCT), Occupational Health Unit, Bologna University Hospital-Sant'Orsola-Malpighi Polyclinic, Royal Institute of Technology [Stockholm] (KTH ), NICTA [Eveleigh], National ICT Australia [Sydney] (NICTA), Division of Solid Mechanics, Lund University [Lund], University of Calgary, BioWare Corp, Manchester Academic Health Sciences Centre, Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Ghent University [Belgium] (UGENT), Imaging Sciences and Biomedical Engineering Division [London], Guy's and St Thomas' Hospital [London]-King‘s College London, Children’s Hospital of Philadelphia (CHOP ), Perelman School of Medicine, University of Pennsylvania [Philadelphia], Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Génie Civil et Mécanique (GeM), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Department of Physiology, Augusta University - Medical College of Georgia, University System of Georgia (USG)-University System of Georgia (USG), Neurorestoration Group, Wolfson Centre for Age-related Diseases-King‘s College London, Electronic Navigation Research Institute (ENRI), Ministry of Land, Infrastructure, Transport and Tourism, Department of Computer Science [KAIST] (CS), Korea Advanced Institute of Science and Technology (KAIST), Centre for Undergraduate Studies, University of the Punjab, Siemens Corporate Research, Siemens AG [Munich], University of Massachusetts [Boston] (UMass Boston), University of Massachusetts System (UMASS), Department of Materials Science, Sichuan University [Chengdu] (SCU), Natl Engn Res Ctr Vegetables, Key Lab Biol & Genet Improvement Hort Crops N Chi, Beijing Acad Agr & Forestry Sci, University Hospital Puerta de Hierro, Madrid, Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University (PSL), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Shahid Beheshti University of Medical Sciences, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), MOLTECH-ANJOU (MOLTECH-ANJOU), Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), Universidad de Santiago de Chile [Santiago] (USACH)-Universidad del Desarrollo, Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), École supérieure du professorat et de l'éducation - Académie de Grenoble (ESPE Grenoble), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Grenoble Alpes (UGA), California Institute of Technology (CALTECH)-NASA, Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Sud - Paris 11 (UP11), Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universidad de Santiago de Chile [Santiago] (USACH), École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), King‘s College London-Wolfson Centre for Age-related Diseases, Sichuan University, Universitat de Barcelona, Interne Geneeskunde, Medische Sociologie, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Mines-Télécom [Paris] (IMT)-Télécom Bretagne-Université européenne de Bretagne - European University of Brittany (UEB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), RS: MHeNs - R2 - Mental Health, Laboratoire de Physique des Solides ( LPS ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de psychologie sociale et de psychologie cognitive ( LAPSCO ), Université Blaise Pascal - Clermont-Ferrand 2 ( UBP ) -Centre National de la Recherche Scientifique ( CNRS ), Erosion torrentielle neige et avalanches ( UR ETGR ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture ( IRSTEA ), Hong Kong Baptist University ( HKBU ), Institut für Informatik [München/Munich] ( LMU ), Ludwig-Maximilians-Universität München, Neuroépidémiologie Tropicale ( NET ), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ), Insight Centre for Data Analytics (National University of Ireland Galway (NUIG)) ( INSIGHT ), Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), University of Oslo ( UiO ) -University of Oslo ( UiO ), Centro de Estudios Avanzados en Zonas Aridas ( CEAZA ), Ecole Polytechnique Fédérale de Lausanne ( EPFL ), Laboratoire d'Ingénierie des Matériaux ( LIM ), Centre National de la Recherche Scientifique ( CNRS ), Lawrence Berkeley National Laboratory [Berkeley] ( LBNL ), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) ( SRI-B ), Computational Science and Engineering Department [Daresbury] ( STFC ), Multimedia Research Center ( MRC ), University of Alberta [Edmonton], Division of Biostatistics ( Biostat - MINNEAPOLIS ), University of Minnesota [Minneapolis], University of Southampton [Southampton], Interactions, transferts, ruptures artistiques et culturels - EA 6301 ( InTRu ), Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), University Medical Center Utrecht, Biologie Fonctionnelle et Adaptative ( BFA ), Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, Unité de recherche Virologie et Immunologie Moléculaires ( VIM ), Institut National de la Recherche Agronomique ( INRA ), National University of Singapore ( NUS ), Centre de Robotique ( CAOR ), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University ( PSL ), Department of Signal Theory and Communications ( TSC ), RESPEC ( RESPEC ), Advanced Laboratories on Embedded Systems [Roma] ( ALES ), Wageningen University and Research Centre [Wageningen] ( WUR ), Universitat Politècnica de Catalunya [Barcelona] ( UPC ), Institut National de Recherche et d'Analyse Physico-Chimique ( INRAP ), Institut National de Recherche et d'Analyse Physico-chimique (INRAP-Tunisie), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) ( FEMTO-ST ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ), Tehran University, Sociétés, Acteurs, Gouvernement en Europe ( SAGE ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale ( SESSTIM - U912 INSERM - AMU - IRD ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Washington State University ( WSU ), Laboratoire de Physique de l'ENS Lyon ( Phys-ENS ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut des Sciences Chimiques de Rennes ( ISCR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Ecole Nationale Supérieure de Chimie de Rennes-Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en informatique de Toulouse ( IRIT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Toulouse 1 Capitole ( UT1 ) -Université Toulouse - Jean Jaurès ( UT2J ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche en Automatique de Nancy ( CRAN ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Université Catholique de Louvain ( UCL ), Freie Universität Berlin [Berlin], Div Cyclotron & Radiopharmaceut Sci ( DRDO, INMAS ), Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Tata Research Development and Design Center ( TRDDC ), Laboratoire MOLTECH-Anjou [Angers] ( MOLTECH ANJOU ), Université d'Angers ( UA ) -Centre National de la Recherche Scientifique ( CNRS ), University of Helsinki [Helsinki], Swedish Defense Research Agency ( FOI ), Servicio de Neurologia ( SANTIAGO - Neurologie ), Universidad de Santiago de Chile [Santiago] ( USACH ) -Universidad del Desarrollo, Novartis Pharmaceutical Corp., East Hanover NJ 07936, USA, Laboratoire de glaciologie et géophysique de l'environnement ( LGGE ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Mechanical and Automation Engineering ( CAD Laboratory ), National Institutes of Health ( NIH ), Centre d'étude et de recherche en informatique et communications ( CEDRIC ), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise ( ENSIIE ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ), Heuristique et Diagnostic des Systèmes Complexes [Compiègne] ( Heudiasyc ), Université de Technologie de Compiègne ( UTC ) -Centre National de la Recherche Scientifique ( CNRS ), College of Information and Electrical Engineering [Beijing] ( CIEE ), China Agricultural University ( CAU ), Queen Mary University of London ( QMUL ), Centre d'économie de la Sorbonne ( CES ), Université Panthéon-Sorbonne ( UP1 ) -Centre National de la Recherche Scientifique ( CNRS ), Paris School of Economics ( PSE ), École supérieure du professorat et de l'éducation - Académie de Grenoble ( ESPE Grenoble ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Université Grenoble Alpes ( UGA ), PennState University [Pennsylvania] ( PSU ), Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), American University of Beirut [Beyrouth], The University of Sydney [Sydney], Département Optique ( OPT ), Université européenne de Bretagne ( UEB ) -Télécom Bretagne-Institut Mines-Télécom [Paris], Laboratoire des signaux et systèmes ( L2S ), Université Paris-Sud - Paris 11 ( UP11 ) -CentraleSupélec-Centre National de la Recherche Scientifique ( CNRS ), Center for Research in Environmental Epidemiology ( CREAL ), Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique ( INRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for TeleInFrastruktur ( CTIF ), Aalborg University [Denmark] ( AAU ), Savoirs, Textes, Langage (STL) - UMR 8163 ( STL ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Indian Institute of Technology Madras ( IIT Madras ), Universidade Estadual Paulista Júlio de Mesquita ( UNESP ), Laboratoire de Génie Informatique et Ingénierie de Production ( LGI2P ), IMT - Mines Alès Ecole Mines - Télécom ( IMT - MINES ALES ), Institut geològic de Catalunya ( IGC ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physiologie et Génomique des Poissons ( LPGP ), Institut National de la Recherche Agronomique ( INRA ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Politecnico di Milano [Milan], European Microsoft Innovation Center ( EMIC ), Laboratoire de Mécanique, Physique et Géosciences ( LMPG ), Université Le Havre Normandie ( ULH ), Normandie Université ( NU ) -Normandie Université ( NU ), University of Cambridge [UK] ( CAM ), Laboratoire de Probabilités et Modèles Aléatoires ( LPMA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Génétique et de Biologie Moléculaire et Cellulaire ( IGBMC ), Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Center for Mathematical Modeling ( CMM ), Universidad de Santiago de Chile [Santiago] ( USACH ), London School of Hygiene and Tropical Medicine ( LSHTM ), University of Occupational and Environmental Health [Kitakyushu] ( UEOH ), Indian Institute of Technology Delhi ( IIT Delhi ), Institut de Recherche sur les Phénomènes Hors Equilibre ( IRPHE ), Aix Marseille Université ( AMU ) -Ecole Centrale de Marseille ( ECM ) -Centre National de la Recherche Scientifique ( CNRS ), Universidade Federal de Pernambuco [Recife] ( UFPE ), Nanoscience Institute ( NEST ), Laboratory Of Immune Cell Biology ( LICB ), JRC Institute for Environment and Sustainability ( IES ), European Commission - Joint Research Centre [Ispra] ( JRC ), Bonn Universität [Bonn], Laboratorio Nacional de Computação Cientifica [Rio de Janeiro] ( LNCC / MCT ), Royal Institute of Technology [Stockholm] ( KTH ), National ICT Australia [Sydney] ( NICTA ), Institut d'Histoire et de Philosophie des Sciences et des Techniques ( IHPST ), Université Panthéon-Sorbonne ( UP1 ) -Département d'Etudes Cognitives - ENS Paris ( DEC ), École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ), Ghent University [Belgium] ( UGENT ), Children’s Hospital of Philadelphia ( CHOP ), Univeristy of Pennsylvania Medical School, Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique ( LHEEA ), École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche en Génie Civil et Mécanique ( GeM ), Université de Nantes ( UN ) -École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Medical College of Georgia, Electronic Navigation Research Institute ( ENRI ), Department of Computer Science [KAIST] ( CS ), Korea Advanced Institute of Science and Technology ( KAIST ), Laboratoire de l'Accélérateur Linéaire ( LAL ), University of Massachusetts [Boston] ( UMass Boston ), Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H. Ro, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Kc, Astha, Kyu, Hmwe H, Moradi Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu Rmeileh, Niveen M. E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, Françoi, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Cunningham, Solveig Argeseanu, Arnlöv, Johan, Arsenijevic, Valentina S. Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charle, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker Collo, Suzanne L, Barquera, Simon, Barregard, Lar, Barrero, Lope H, Barrientos Gutierrez, Tonatiuh, Basto Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Ruvalcaba, Carolina Bati, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Bori, Abdulhak, Aref A. Bin, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Başara, Berrak Bora, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D. M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G. 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Subjects: Male, Fine particulate matter, Nutrition and Disease, MESH : Sanitation, Health Behavior, Diseases, MESH: Metabolic Diseases, MESH: Global Health, 030204 cardiovascular system & hematology, MESH: Risk Assessment, Global Health, MESH : Nutritional Status, MESH: Occupational Exposure, 0302 clinical medicine, Unsafe Sex, MESH: Risk Factors, Risk Factors, Voeding en Ziekte, Medicine, Air-pollution, MESH : Female, 030212 general & internal medicine, MESH : Risk Assessment, Sanitation, Wasting, 2. Zero hunger, Factors de risc en les malalties, Medicine (all), [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, MESH : Occupational Diseases, MESH: Nutritional Status, All-cause mortality, MESH : Risk Factors, humanities, Environmental Exposure, Female, Humans, Metabolic Diseases, Nutritional Status, Occupational Diseases, Occupational Exposure, Risk Assessment, Tobacco smoking, 3. Good health, Nutritional Statu, MESH : Occupational Exposure, MESH : Metabolic Diseases, Cohort, medicine.symptom, Risk assessment, Blood-pressure, Human, MESH: Occupational Diseases, Risk factors in diseases, Coronary-heart-disease, MESH : Male, MESH: Health Behavior, MESH: Environmental Exposure, Population health, Body-mass index, 03 medical and health sciences, Household cooking, Cardiovascular-disease, Environmental health, General & Internal Medicine, parasitic diseases, Life Science, MESH: Sanitation, Risk factor, MESH : Health Behavior, VLAG, GBD2013, MESH: Humans, business.industry, Risk Factor, Global Burden of Disease Study, 79 behavioural, environmental and occupational, and metabolic risks, Long-term exposure, MESH : Humans, CAUSE-SPECIFIC MORTALITY, MESH: Male, Metabolic Disease, Occupational Disease, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, MALE BRITISH DOCTORS, Years of potential life lost, Relative risk, Malalties, MESH : Global Health, OUTDOOR AIR-POLLUTION, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH : Environmental Exposure, MESH: Female
Abstract: Summary Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation. Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the fi rst of a series of annual updates of the GBD. Risk factor quantifi cation, particularly of modifi able risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the fi rst level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular fi ltration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8–58·5) of deaths and 41·6% (40·1–43·0) of DALYs. Risks quantified account for 87·9% (86·5−89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa. Interpretation Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks. Funding Bill & Melinda Gates Foundation.
Published: 2015

94. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013

Author: Meghan D. Mooney, Ken Takahashi, Andrea Stewart, Jonathan C Brown, Shireen Sindi, Amany H Refaat, Ruben Castro, Sara Sheikhbahaei, Kyle R. Heuton, Gillian M. Hansen, Chante Karimkhani, Bryan K. Phillips, Ibrahim Abubakar, Yohannes Kinfu, Victoria F Bachman, Konstantinos Stroumpoulis, Megan Coggeshall, Lucía Cuevas-Nasu, Yichong Li, Vineet K. Chadha, Andrew G. M. Bulloch, Takayoshi Ohkubo, Don C. Des Jarlais, Giancarlo Logroscino, Francis Apolinary Mhimbira, Jefferson G Fernandes, Cheng Huang, Ejaz Ahmad Khan, Fortuné Gbètoho Gankpé, Roderick J Hay, Itamar S. Santos, Zanfina Ademi, Fiona J Charlson, Norlinah Mohamed Ibrahim, Anwar Rafay, Andrew L. Thorne-Lyman, Juanita A. Haagsma, Emmanuel A. Ameh, John J. McGrath, Massimo Cirillo, Wubegzier Mekonnen, Holly Hagan, Naohiro Yonemoto, Frida Namnyak Ngalesoni, Dietrich Plass, Matias Trillini, David Phillips, Braden Te Ao, Wanqing Chen, Yun Jin Kim, David Rojas-Rueda, Christina Papachristou, Andrew E. Moran, Richard A. Gosselin, Maziar Moradi-Lakeh, Soraya Seedat, Janet L Leasher, Belinda K Lloyd, Lorenzo Monasta, Bruno F. Sunguya, Eun-Kee Park, Eduardo A. Undurraga, Mohammad A. AlMazroa, Mohammad H. Forouzanfar, Young-Ho Khang, Vasiliki Stathopoulou, Dima M. Qato, James Scott, Ileana Heredia-Pi, Luca Ronfani, Haidong Kan, Tasara T. Mazorodze, Murugesan Raju, Saeid Shahraz, Taavi Tillmann, Wang Wenzhi, Neil Pearce, Eric Y. Tenkorang, Aliya Naheed, Ferrán Catalá-López, Sudan Prasad Neupane, Emily Dansereau, Michael McKee, Derrick A Bennett, Mazeda Hossain, Paul S. F. Yip, Grant Nguyen, Norberto Perico, Miguel Angel Alegretti, Babak Eshrati, Boris Bikbov, Palwasha Anwari, Guoqing Hu, Amelia Bertozzi-Villa, Peter A. Meaney, Farshad Farzadfar, Svetlana Popova, Tara Templin, Hmwe H Kyu, Uche S. Uchendu, Kebede Deribe, Sergey Soshnikov, Nobhojit Roy, Daniel Kim, Ilana N. Ackerman, Homie Razavi, Leslie T. Cooper, Sandra Nolte, David T. Felson, John J Huang, Yang Liu, Fiorella Cavalleri, Adrian Davis, Héctor Gómez Dantés, Klara Dokova, Yuantao Hao, Catalina Medina, Austin E Schumacher, Stan Biryukov, Jane Rowley, Arindam Basu, Jose C. Adsuar, Rosana E. Norman, Yousef Khader, Rafael Alfonso-Cristancho, Sukanta Saha, Simón Barquera, Diego Gonzalez-Medina, Philip B. Mitchell, Lars Barregard, Haidong Wang, Yongmei Li, Ami R. Moore, Marie Ng, Raghib Ali, Peter T. Serina, Lijing L Yan, Ayse Abbasoglu Ozgoren, Ricky Leung, Michelle L. Bell, Tim Driscoll, Azmeraw T. Amare, Farshad Pourmalek, Tea Lallukka, Benjamin O Anderson, Raimundas Lunevicius, Corine Karema, Robert G. Weintraub, Erin C Mullany, Anders Larsson, Glen Mola, Paulo A. Lotufo, Luke Nyakarahuka, Sayed Saidul Alam, Louisa Degenhardt, Hugh R. Taylor, E. Ray Dorsey, Suzanne Polinder, Hilton Lam, Urbano Fra Paleo, David Zonies, Rahman Shiri, Marco A Avila, Alicia Elena Beatriz Lawrynowicz, Katya Anne Shackelford, Lynne Gaffikin, Konstantin Kazanjan, Mark T Mackay, Jasvinder A. Singh, Bryan L. Sykes, Sadaf G. Sepanlou, Chantal Huynh, Rakhi Dandona, Logan Sandar, Lavanya Singh, Dietrich Rothenbacher, Theo Vos, Steven E. Lipshultz, Coen H. Van Gool, Peggy P. Chiang, Mark G. Shrime, Christopher J L Murray, Scott Weichenthal, Jae-Hyun Park, Samia Alhabib, Philimon Gona, Christian Kieling, Yuichiro Yano, Ronny Westerman, Thomas Truelsen, Rajeev Gupta, Megan Bohensky, Abdullatif Husseini, Qing Lan, Luke D. Knibbs, Yousef M. Elshrek, H. Ross Anderson, Guohong Jiang, Madeline L. Moyer, Vinod K. Paul, Wim H. van Brakel, Emin Murat Tuzcu, Kara Estep, Lalit Dandona, Uchechukwu K.A. Sampson, Mohammad Tavakkoli, Ying Jiang, Joseph A Wagner, Mitsuru Mukaigawara, In-Hwan Oh, Siyi Shangguan, Noela M. Prasad, Charles D.A. Wolfe, Borja del Pozo-Cruz, Gokalp Kadri Yentur, Hilda L Harb, Elena Alvarez, Carlos A Castañeda-Orjuela, Mustafa Z. Younis, Herbert C. Duber, Erica Leigh Slepak, George A. Mensah, Knud Juel, Graeme J. Hankey, Natan M. Bornstein, Martha Híjar, Johan Ärnlöv, Mohamed Hsairi, Katherine T. Lofgren, Murray B. Stein, Renata Micha, Luigi Naldi, Margreet ten Have, Bolajoko O. Olusanya, Kyle J Foreman, Kenji Shibuya, F. Gerry R. Fowkes, Abdullah Sulieman Terkawi, Rana J. Asghar, Karen M. Tabb, Kovin Naidoo, Rogelio Pérez-Padilla, Honglei Chen, Antônio Luiz Pinho Ribeiro, Rasmus Havmoeller, Yukito Shinohara, Bongani M. Mayosi, Ernst J Kuipers, Konrad Pesudovs, Mouhanad Hammami, Lee Richardson, Rintaro Mori, Thomas D. Fleming, Pouria Heydarpour, Stephen G. Waller, Nicholas Graetz, Chanda Kulkarni, Peter Brooks, Gulfaraz Khan, Marcel Tanner, Van C. Lansingh, François Alla, Jamie Hancock, Yohannes Adama Melaku, Neeraj Bedi, Anthony D. Woolf, Tariku Jibat Beyene, Amanda W Pain, Eric L. Ding, Narayanaswamy Venketasubramanian, Semaw Ferede Abera, Devina Nand, Odgerel Chimed-Ochir, George D Thurston, Victor Aboyans, Alanur Çavlin, Jefferson Traebert, Michael R. Phillips, Yingfeng Zheng, Baffour Awuah, Carlo Irwin A. Panelo, Selen Begüm Uzun, Muhammad Imran Nisar, Samir Soneji, Veena S. Kulkarni, Mukesh Dherani, Stephen S Lim, Andre Keren, Kingsley N. Ukwaja, Sajjad Ur Rahman, Giuseppe Remuzzi, Kjetil Søreide, Blake Thomson, Samath D Dharmaratne, Christopher D. Blosser, David H. Rothstein, Amanda G. Thrift, Fabrizio Tediosi, Andrew H. Kemp, H. Dean Hosgood, Yoshihiro Kokubo, Miia Kivipelto, Amitava Banerjee, Edgar P. Simard, Reza Malekzadeh, Maggie Lind, Robert P. Dellavalle, Emerito Jose A. Faraon, Lydia S. Atkins, Tom Achoki, Aslam Pervaiz, Peter Scarborough, Hans W. Hoek, Ettore Beghi, Emilie Agardh, Abraham D. Flaxman, Dariush Mozaffarian, Juan R. Sanabria, Muluken Dessalegn, David C. Schwebel, Caitlyn Steiner, Ubai Alsharif, Richard C. Franklin, Gail Davey, Gelin Xu, Reyna A Gutiérrez, Joannie Lortet-Tieulent, Ashish Bhalla, Jost B. Jonas, Paul N. Jensen, Simon I. Hay, Xiaonong Zou, Andre Pascal Kengne, Tolesa Bekele, Brittany Wurtz, Jung-Chen Chang, Joseph Murray, Luciano A. Sposato, Stefan Ma, Summer Lockett Ohno, Charles R. Newton, Bradford D. Gessner, JianLi Wang, Scott B. Patten, Thomas Fürst, Carol Brayne, Christina Fitzmaurice, Peilin Shi, Ted R. Miller, Kinnari S. Murthy, Habib Benzian, Peter W. Gething, Cesar Diaz-Torne, Burcu Kucuk Bicer, Bo Norrving, Carly E Levitz, Adam D M Briggs, Sungroul Kim, Isabela M. Benseñor, John A. Crump, Sergey Petrovich Ermakov, Kalpana Balakrishnan, Awoke Misganaw Temesgen, Marcella Montico, Sanjay Krishnaswami, Kim Moesgaard Iburg, Ann Kristin Knudsen, Sun Ha Jee, Valery L. Feigin, Christine M. Budke, Anne Bulchis, Anand Dayama, Jonathan R. Carapetis, Cyrus Cooper, Teresa Shamah Levy, Ismael R. Campos-Nonato, Nataliya A. Foigt, Beth E. Ebel, Max Petzold, Heresh Amini, Ole Frithjof Norheim, Zulfiqar A Bhutta, Dan Poenaru, Jim van Os, Michele E. Murdoch, Samantha M. Colquhoun, Michael H. Criqui, Giorgia Giussani, Man Mohan Mehndiratta, Thomas N. Williams, Chandrashekhar T Sreeramareddy, Chuanhua Yu, Luis M. Coppola, Thomas J. Montine, Alaa Badawi, Eduardo Bernabé, Melvin Barrientos Marzan, James Leigh, Frédéric B. Piel, Ratilal Lalloo, Panniyammakal Jeemon, Maheswar Satpathy, Hélène Carabin, Corina Benjet, Seyed-Mohammad Fereshtehnejad, Ryan M Barber, Fotis Topouzis, Bin Li, Serge Resnikoff, Taavi Lai, Rachelle Buchbinder, Randah R. Hamadeh, Valeria Caso, Holly E. Erskine, Dragos Virgil Davitoiu, Miltiadis K. Tsilimbaris, Rachel L. Pullan, Ben Schöttker, Rafael Lozano, Damian G Hoy, Fiona M. Blyth, Belinda J. Gabbe, Hebe N. Gouda, Farhad Islami, Atte Meretoja, Christopher Margono, Marissa Iannarone, Ronan A Lyons, Wilkister N. Moturi, Donald H. Silberberg, Alexandra Brazinova, Monica Cortinovis, Deena Alasfoor, Richard Matzopoulos, Jerry Abraham, Francesco Saverio Violante, Monika Sawhney, Dorairaj Prabhakaran, Valentina Colistro, Derek F J Fay, Mamta Swaroop, Nima Hafezi-Nejad, John Nelson Opio, Hanne Christensen, Jun She, Soewarta Kosen, Atsushi Goto, Costas A. Christophi, Jeyaraj D. Pandian, Peter J. Hotez, K. Srinath Reddy, Al Artaman, Peter Allebeck, Jonas Minet Kinge, Graham S Cooke, Dan J. Stein, Kawkab Shishani, Laith J. Abu-Raddad, Katrina F Ortblad, Deborah Jarvis, Arsène Kouablan Adou, Barthelemy Kuate Defo, Alan D. Lopez, G Anil Kumar, K.M. Venkat Narayan, Yong Zhao, Rajiv Chowdhury, Hadi Danawi, George C Patton, Vasiliy Victorovich Vlassov, André Karch, Tommi J. Vasankari, Matthias Endres, Ione Jayce Ceola Schneider, Nelson Alvis-Guzman, Charles N Mock, Katharine J Looker, Bach Xuan Tran, Fernando Perez-Ruiz, Harish Chander Gugnani, Reza Assadi, Hannah Hamavid, Rosario Cárdenas, Mohammed I. Albittar, Sarah Derrett, Mohammad Yahya Saeedi, Traolach S. Brugha, Jan Hendrik Richardus, Alireza Esteghamati, Seok Jun Yoon, Josep Maria Haro, Michael Brainin, Ziad A. Memish, Rupert R A Bourne, Katherine B Gibney, David M. Pereira, Kathryn H. Jacobsen, Luc E. Coffeng, Joshua A. Salomon, Xia Wan, Ian Bolliger, Boris I. Pavlin, Karen Sliwa, Tati S. Warouw, Geoffrey Buckle, Chakib Nejjari, Diego De Leo, Ashkan Afshin, Vinay Nangia, Daniel Pope, Johanna M. Geleijnse, Nikhil Tandon, Kelly Bienhoff, Jed D. Blore, Walid Ammar, D. Allen Roberts, Elisabete Weiderpass, Gregory A. Roth, Manami Inoue, James D. Wilkinson, Hideaki Toyoshima, Soufiane Boufous, Ivy Shiue, Edward J Mills, Leilei Duan, Matthew M Coates, Ganesan Karthikeyan, Alberto Ortiz, Steven van de Vijver, David Carpenter, Suzanne Lyn Barker-Collo, Antony Stevens, Sanjay Basu, Maria Cecilia Bahit, Kaire Innos, Lindsay N. Boyers, Nicholas J K Breitborde, Alize J. Ferrari, Timothy M. Wolock, Simerjot K. Jassal, Mohammad Ali Sahraian, Joanna Moschandreas, Howard J. Hoffman, Hideki Higashi, George M. Ruhago, Karzan Abdulmuhsin Mohammad, Mohammed Basulaiman, D. Alex Quistberg, Justin Beardsley, Marcello Tonelli, Maurice Giroud, Karen Edmond, Norito Kawakami, Mohammad T Mashal, Neeraj Bhala, Carl Abelardo T. Antonio, David Tanne, Abhishek Singh, Kazem Rahimi, Vivekanand Jha, Wagner Marcenes, David J. Margolis, Yara A. Halasa, Zewdie Aderaw Alemu, Carrie Beth Peterson, Edson Serván-Mori, Anil Kaul, Foad Abd-Allah, Marek Majdan, Rahul Gupta, Robyn M. Lucas, Sarah Wulf, Lars Jacob Stovner, Mohsen Naghavi, Vegard Skirbekk, Ulrich Otto Mueller, Pengpeng Ye, Ali H. Mokdad, Dipan Bose, Saleem M Rana, Jeffrey D Stanaway, Abigail Mclain, Timothy J. Steiner, Amira Shaheen, Stein Emil Vollset, Andrea Werdecker, Michele Meltzer, Richie G Poulton, Joseph R. Masci, Inga Dora Sigfusdottir, Daniel Dicker, Maysaa El Sayed Zaki, Shiwei Liu, Julio C. 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L, Barber, Ryan M., Foreman, Kyle J., Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Abera, Semaw F., Aboyans, Victor, Abraham, Jerry P., Abubakar, Ibrahim, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M., Achoki, Tom, Ackerman, Ilana N., Ademi, Zanfina, Adou, Arsène K., Adsuar, José C., Afshin, Ashkan, Agardh, Emilie E., Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I., Alegretti, Miguel A., Alemu, Zewdie A., Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Alla, Françoi, Allebeck, Peter, Almazroa, Mohammad A., Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T., Ameh, Emmanuel A., Amini, Heresh, Ammar, Walid, Anderson, H. Ro, Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwari, Palwasha, Arnlöv, Johan, Arsenijevic, Valentina S. Arsic, Artaman, Al, Asghar, Rana J., Assadi, Reza, Atkins, Lydia S., Avila, Marco A., Awuah, Baffour, Bachman, Victoria F., Badawi, Alaa, Bahit, Maria C., Balakrishnan, Kalpana, Banerjee, Amitava, Barker-Collo, Suzanne L., Barquera, Simon, Barregard, Lar, Barrero, Lope H., Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O., Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bekele, Tolesa, Bell, Michelle L., Benjet, Corina, Bennett, Derrick A., Bensenor, Isabela M., Benzian, Habib, Bernabé, Eduardo, Bertozzi-Villa, Amelia, Beyene, Tariku J., Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A., Bienhoff, Kelly, Bikbov, Bori, Biryukov, Stan, Blore, Jed D., Blosser, Christopher D., Blyth, Fiona M., Bohensky, Megan A., Bolliger, Ian W., Başara, Berrak Bora, Bornstein, Natan M., Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R. A., Boyers, Lindsay N., Brainin, Michael, Brayne, Carol E., Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Briggs, Adam D., Brooks, Peter M., Brown, Jonathan C., Brugha, Traolach S., Buchbinder, Rachelle, Buckle, Geoffrey C., Budke, Christine M., Bulchis, Anne, Bulloch, Andrew G., Campos-Nonato, Ismael R., Carabin, Hélène, Carapetis, Jonathan R., Cárdenas, Rosario, Carpenter, David O., Caso, Valeria, Castañeda-Orjuela, Carlos A., Castro, Ruben E., Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K., Chang, Jung-Chen, Charlson, Fiona J., Chen, Honglei, Chen, Wanqing, Chiang, Peggy P., Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christensen, Hanne, Christophi, Costas A., Cirillo, Massimo, Coates, Matthew M., Coffeng, Luc E., Coggeshall, Megan S., Colistro, Valentina, Colquhoun, Samantha M., Cooke, Graham S., Cooper, Cyru, Cooper, Leslie T., Coppola, Luis M., Cortinovis, Monica, Criqui, Michael H., Crump, John A., Cuevas-Nasu, Lucia, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dansereau, Emily, Dargan, Paul I., Davey, Gail, Davis, Adrian, Davitoiu, Dragos V., Dayama, Anand, De Leo, Diego, Degenhardt, Louisa, Del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribe, Kebede, Derrett, Sarah, Des Jarlais, Don C., Dessalegn, Muluken, Dharmaratne, Samath D., Dherani, Mukesh K., Diaz-Torné, Cesar, Dicker, Daniel, Ding, Eric L., Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R., Duan, Leilei, Duber, Herbert C., Ebel, Beth E., Edmond, Karen M., Elshrek, Yousef M., Endres, Matthia, Ermakov, Sergey P., Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Estep, Kara, Faraon, Emerito Jose A., Farzadfar, Farshad, Fay, Derek F., Feigin, Valery L., Felson, David T., Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G., Ferrari, Alize J., Fitzmaurice, Christina, Flaxman, Abraham D., Fleming, Thomas D., Foigt, Nataliya, Forouzanfar, Mohammad H., Fowkes, F Gerry R., Paleo, Urbano Fra., Franklin, Richard C., Fürst, Thoma, Gabbe, Belinda, Gaffikin, Lynne, Gankpé, Fortuné G., Geleijnse, Johanna M., Gessner, Bradford D., Gething, Peter, Gibney, Katherine B., Giroud, Maurice, Giussani, Giorgia, Dantes, Hector Gomez, Gona, Philimon, González-Medina, Diego, Gosselin, Richard A., Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Graetz, Nichola, Gugnani, Harish C., Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A., Haagsma, Juanita, Hafezi-Nejad, Nima, Hagan, Holly, Halasa, Yara A., Hamadeh, Randah R., Hamavid, Hannah, Hammami, Mouhanad, Hancock, Jamie, Hankey, Graeme J., Hansen, Gillian M., Hao, Yuantao, Harb, Hilda L., Haro, Josep Maria, Havmoeller, Rasmu, Hay, Simon I., Hay, Roderick J., Heredia-Pi, Ileana B., Heuton, Kyle R., Heydarpour, Pouria, Higashi, Hideki, Hijar, Martha, Hoek, Hans W., Hoffman, Howard J., Hosgood, H Dean, Hossain, Mazeda, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Hu, Guoqing, Huang, Cheng, Huang, John J., Husseini, Abdullatif, Huynh, Chantal, Iannarone, Marissa L., Iburg, Kim M., Innos, Kaire, Inoue, Manami, Islami, Farhad, Jacobsen, Kathryn H., Jarvis, Deborah L., Jassal, Simerjot K., Jee, Sun Ha, Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jiang, Guohong, Jiang, Ying, Jonas, Jost B., Juel, Knud, Kan, Haidong, Karch, André, Karema, Corine K., Karimkhani, Chante, Karthikeyan, Ganesan, Kassebaum, Nicholas J., Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Kemp, Andrew H., Kengne, Andre P., Keren, Andre, Khader, Yousef S., Khalifa, Shams Eldin A., Khan, Ejaz A., Khan, Gulfaraz, Khang, Young-Ho, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kinfu, Yohanne, Kinge, Jonas M., Kivipelto, Miia, Knibbs, Luke D., Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kosen, Soewarta, Krishnaswami, Sanjay, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J., Kulkarni, Chanda, Kulkarni, Veena S., Kumar, G Anil, Kyu, Hmwe H., Lai, Taavi, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C., Larsson, Ander, Lawrynowicz, Alicia E. B., Leasher, Janet L., Leigh, Jame, Leung, Ricky, Levitz, Carly E., Li, Bin, Li, Yichong, Li, Yongmei, Lim, Stephen S., Lind, Maggie, Lipshultz, Steven E., Liu, Shiwei, Liu, Yang, Lloyd, Belinda K., Lofgren, Katherine T., Logroscino, Giancarlo, Looker, Katharine J., Lortet-Tieulent, Joannie, Lotufo, Paulo A., Lozano, Rafael, Lucas, Robyn M., Lunevicius, Raimunda, Lyons, Ronan A., Ma, Stefan, Macintyre, Michael F., Mackay, Mark T., Majdan, Marek, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David J., Margono, Christopher, Marzan, Melvin B., Masci, Joseph R., Mashal, Mohammad T., Matzopoulos, Richard, Mayosi, Bongani M., Mazorodze, Tasara T., Mcgill, Neil W., Mcgrath, John J., Mckee, Martin, Mclain, Abigail, Meaney, Peter A., Medina, Catalina, Mehndiratta, Man Mohan, Mekonnen, Wubegzier, Melaku, Yohannes A., Meltzer, Michele, Memish, Ziad A., Mensah, George A., Meretoja, Atte, Mhimbira, Francis A., Micha, Renata, Miller, Ted R., Mills, Edward J., Mitchell, Philip B., Mock, Charles N., Ibrahim, Norlinah Mohamed, Mohammad, Karzan A., Mokdad, Ali H., Mola, Glen L. D., Monasta, Lorenzo, Hernandez, Julio C. Montañez, Montico, Marcella, Montine, Thomas J., Mooney, Meghan D., Moore, Ami R., Moradi-Lakeh, Maziar, Moran, Andrew E., Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N., Moyer, Madeline L., Mozaffarian, Dariush, Msemburi, William T., Mueller, Ulrich O., Mukaigawara, Mitsuru, Mullany, Erin C., Murdoch, Michele E., Murray, Joseph, Murthy, Kinnari S., Naghavi, Mohsen, Naheed, Aliya, Naidoo, Kovin S., Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K M. Venkat, Nejjari, Chakib, Neupane, Sudan P., Newton, Charles R., Ng, Marie, Ngalesoni, Frida N., Nguyen, Grant, Nisar, Muhammad I., Nolte, Sandra, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Ohno, Summer L., Olusanya, Bolajoko O., Opio, John Nelson, Ortblad, Katrina, Ortiz, Alberto, Pain, Amanda W., Pandian, Jeyaraj D., Panelo, Carlo Irwin A., Papachristou, Christina, Park, Eun-Kee, Park, Jae-Hyun, Patten, Scott B., Patton, George C., Paul, Vinod K., Pavlin, Boris I., Pearce, Neil, Pereira, David M., Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B., Petzold, Max, Phillips, Michael R., Phillips, Bryan K., Phillips, David E., Piel, Frédéric B., Plass, Dietrich, Poenaru, Dan, Polinder, Suzanne, Pope, Daniel, Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M., Pullan, Rachel L., Qato, Dima M., Quistberg, D Alex, Rafay, Anwar, Rahimi, Kazem, Rahman, Sajjad U., Raju, Murugesan, Rana, Saleem M., Razavi, Homie, Reddy, K Srinath, Refaat, Amany, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L., Richardson, Lee, Richardus, Jan Hendrik, Roberts, D Allen, Rojas-Rueda, David, Ronfani, Luca, Roth, Gregory A., Rothenbacher, Dietrich, Rothstein, David H., Rowley, Jane T., Roy, Nobhojit, Ruhago, George M., Saeedi, Mohammad Y., Saha, Sukanta, Sahraian, Mohammad Ali, Sampson, Uchechukwu K. A., Sanabria, Juan R., Sandar, Logan, Santos, Itamar S., Satpathy, Maheswar, Sawhney, Monika, Scarborough, Peter, Schneider, Ione J., Schöttker, Ben, Schumacher, Austin E., Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Serina, Peter T., Servan-Mori, Edson E., Shackelford, Katya A., Shaheen, Amira, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shi, Peilin, Shibuya, Kenji, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga D., Silberberg, Donald H., Simard, Edgar P., Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A., Singh, Lavanya, Skirbekk, Vegard, Slepak, Erica Leigh, Sliwa, Karen, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stanaway, Jeffrey D., Stathopoulou, Vasiliki, Stein, Dan J., Stein, Murray B., Steiner, Caitlyn, Steiner, Timothy J., Stevens, Antony, Stewart, Andrea, Stovner, Lars J., Stroumpoulis, Konstantino, Sunguya, Bruno F., Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L., Tabb, Karen M., Takahashi, Ken, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Taylor, Hugh R., Te Ao, Braden J., Tediosi, Fabrizio, Temesgen, Awoke M., Templin, Tara, Ten Have, Margreet, Tenkorang, Eric Y., Terkawi, Abdullah S., Thomson, Blake, Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tillmann, Taavi, Tonelli, Marcello, Topouzis, Foti, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X., Trillini, Matia, Truelsen, Thoma, Tsilimbaris, Miltiadi, Tuzcu, Emin M., Uchendu, Uche S., Ukwaja, Kingsley N., Undurraga, Eduardo A., Uzun, Selen B., Van Brakel, Wim H., Van De Vijver, Steven, Van Gool, Coen H., Van Os, Jim, Vasankari, Tommi J., Venketasubramanian, N, Violante, Francesco S., Vlassov, Vasiliy V., Vollset, Stein Emil, Wagner, Gregory R., Wagner, Joseph, Waller, Stephen G., Wan, Xia, Wang, Haidong, Wang, Jianli, Wang, Linhong, Warouw, Tati S., Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Wenzhi, Wang, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A., Wilkinson, James D., Williams, Thomas N., Wolfe, Charles D., Wolock, Timothy M., Woolf, Anthony D., Wulf, Sarah, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L., Yano, Yuichiro, Ye, Pengpeng, Yentür, Gökalp K., Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Yu, Chuanhua, Zaki, Maysaa E., Zhao, Yong, Zheng, Yingfeng, Zonies, David, Zou, Xiaonong, Salomon, Joshua A., Lopez, Alan D., Vos, Theo, Medische Sociologie, MUMC+: Hersen en Zenuw Centrum (3), MUMC+: MA Psychiatrie (3), Psychiatrie & Neuropsychologie, Barber, Ryan M, Foreman, Kyle J, Abd Allah, Foad, Abera, Semaw F, Abraham, Jerry P, Abu Raddad, Laith J, Abu Rmeileh, Niveen M, Ackerman, Ilana N, Adou, Arsène K, Adsuar, José C, Agardh, Emilie E, Albittar, Mohammed I, Alegretti, Miguel A, Alemu, Zewdie A, Alfonso Cristancho, Rafael, Almazroa, Mohammad A, Alvis Guzman, Nelson, Amare, Azmeraw T, Ameh, Emmanuel A, Anderson, Benjamin O, Antonio, Carl Abelardo T, Asghar, Rana J, Atkins, Lydia S, Avila, Marco A, Bachman, Victoria F, Bahit, Maria C, Barker Collo, Suzanne L, Barrero, Lope H, Basulaiman, Mohammed O, Bell, Michelle L, Bennett, Derrick A, Bensenor, Isabela M, Bertozzi Villa, Amelia, Beyene, Tariku J, Bhutta, Zulfiqar A, Blore, Jed D, Blosser, Christopher D, Blyth, Fiona M, Bohensky, Megan A, Bolliger, Ian W, Bornstein, Natan M, Bourne, Rupert R. A, Boyers, Lindsay N, Brayne, Carol E, Breitborde, Nicholas J. K, Briggs, Adam D, Brooks, Peter M, Brown, Jonathan C, Brugha, Traolach S, Buckle, Geoffrey C, Budke, Christine M, Bulloch, Andrew G, Campos Nonato, Ismael R, Carapetis, Jonathan R, Carpenter, David O, Castañeda Orjuela, Carlos A, Castro, Ruben E, Catalá López, Ferrán, Chadha, Vineet K, Chang, Jung Chen, Charlson, Fiona J, Chiang, Peggy P, Chimed Ochir, Odgerel, Christophi, Costas A, Coates, Matthew M, Coffeng, Luc E, Coggeshall, Megan S, Colquhoun, Samantha M, Cooke, Graham S, Cooper, Leslie T, Coppola, Luis M, Criqui, Michael H, Crump, John A, Cuevas Nasu, Lucia, Dargan, Paul I, Davitoiu, Dragos V, Del Pozo Cruz, Borja, Dellavalle, Robert P, Jarlais, Don C. De, Dharmaratne, Samath D, Dherani, Mukesh K, Diaz Torné, Cesar, Ding, Eric L, Dorsey, E. 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Dean, Hotez, Peter J, Hoy, Damian G, Huang, John J, Iannarone, Marissa L, Iburg, Kim M, Jacobsen, Kathryn H, Jarvis, Deborah L, Jassal, Simerjot K, Jensen, Paul N, Jonas, Jost B, Karema, Corine K, Kassebaum, Nicholas J, Kemp, Andrew H, Kengne, Andre P, Khader, Yousef S, Khalifa, Shams Eldin A, Khan, Ejaz A, Khang, Young Ho, Kinge, Jonas M, Knibbs, Luke D, Kuipers, Ernst J, Kulkarni, Veena S, Kumar, G. Anil, Kyu, Hmwe H, Lansingh, Van C, Lawrynowicz, Alicia E. B, Leasher, Janet L, Levitz, Carly E, Lim, Stephen S, Lipshultz, Steven E, Lloyd, Belinda K, Lofgren, Katherine T, Looker, Katharine J, Lortet Tieulent, Joannie, Lotufo, Paulo A, Lucas, Robyn M, Lyons, Ronan A, Macintyre, Michael F, Mackay, Mark T, Margolis, David J, Marzan, Melvin B, Masci, Joseph R, Mashal, Mohammad T, Mayosi, Bongani M, Mazorodze, Tasara T, Mcgill, Neil W, Mcgrath, John J, Meaney, Peter A, Melaku, Yohannes A, Memish, Ziad A, Mensah, George A, Mhimbira, Francis A, Miller, Ted R, Mills, Edward J, Mitchell, Philip B, Mock, Charles N, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L. D, Montine, Thomas J, Mooney, Meghan D, Moore, Ami R, Moradi Lakeh, Maziar, Moran, Andrew E, Moturi, Wilkister N, Moyer, Madeline L, Msemburi, William T, Mueller, Ulrich O, Mullany, Erin C, Murdoch, Michele E, Murthy, Kinnari S, Naidoo, Kovin S, Narayan, K. M. Venkat, Neupane, Sudan P, Newton, Charles R, Ngalesoni, Frida N, Nisar, Muhammad I, Norheim, Ole F, Norman, Rosana E, Oh, In Hwan, Ohno, Summer L, Olusanya, Bolajoko O, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Park, Eun Kee, Park, Jae Hyun, Patten, Scott B, Patton, George C, Paul, Vinod K, Pavlin, Boris I, Pereira, David M, Perez Padilla, Rogelio, Perez Ruiz, Fernando, Peterson, Carrie B, Phillips, Michael R, Phillips, Bryan K, Phillips, David E, Piel, Frédéric B, Poulton, Richie G, Prasad, Noela M, Pullan, Rachel L, Qato, Dima M, Quistberg, D. Alex, Rahman, Sajjad U, Rana, Saleem M, Reddy, K. Srinath, Ribeiro, Antonio L, Roberts, D. Allen, Rojas Rueda, David, Roth, Gregory A, Rothstein, David H, Rowley, Jane T, Ruhago, George M, Saeedi, Mohammad Y, Sampson, Uchechukwu K. A, Sanabria, Juan R, Santos, Itamar S, Schneider, Ione J, Schumacher, Austin E, Schwebel, David C, Scott, James G, Sepanlou, Sadaf G, Serina, Peter T, Servan Mori, Edson E, Shackelford, Katya A, Shrime, Mark G, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Singh, Jasvinder A, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Stein, Dan J, Stein, Murray B, Steiner, Timothy J, Stovner, Lars J, Sunguya, Bruno F, Sykes, Bryan L, Tabb, Karen M, Taylor, Hugh R, Ao, Braden J. Te, Temesgen, Awoke M, Tenkorang, Eric Y, Terkawi, Abdullah S, Thorne Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tran, Bach X, Tuzcu, Emin M, Uchendu, Uche S, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uzun, Selen B, Van Brakel, Wim H, van Gool, Coen H, Vasankari, Tommi J, Violante, Francesco S, Vlassov, Vasiliy V, Wagner, Gregory R, Waller, Stephen G, Warouw, Tati S, Weintraub, Robert G, Whiteford, Harvey A, Wilkinson, James D, Williams, Thomas N, Wolfe, Charles D, Wolock, Timothy M, Woolf, Anthony D, Yan, Lijing L, Yentür, Gökalp K, Yoon, Seok Jun, Younis, Mustafa Z, Zaki, Maysaa E, Salomon, Joshua A, Lopez, Alan D, Computational Science and Engineering Department [Daresbury] ( STFC ), Science & Technologie Facilities Council, Neuroépidémiologie Tropicale ( NET ), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ), Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Weill Cornell Medical College - Qatar, Qatar Foundation - Education City, Doha, Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Karolinska Institute, karolinska institute, Centro de Estudios Avanzados en Zonas Aridas ( CEAZA ), Ecole Polytechnique Fédérale de Lausanne ( EPFL ), Wisconsin Division of Public Health, Regional Genetic Service, St Mary's Hospital, Manchester, Laboratoire d'Ingénierie des Matériaux ( LIM ), Centre National de la Recherche Scientifique ( CNRS ), Computer Science Department [Bristol], University of Bristol [Bristol], Lawrence Berkeley National Laboratory [Berkeley] ( LBNL ), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) ( SRI-B ), Multimedia Research Center ( MRC ), University of Alberta [Edmonton], Division of Biostatistics ( Biostat - MINNEAPOLIS ), University of Minnesota [Minneapolis], Laboratory of Neurologic Diseases, Mario Negri Institute, Milan, University of Southampton [Southampton], Imperial College London, Neurology Department, Ichilov Medical Center, Department of Public Health and Primary Care, Cambridge University, Interactions, transferts, ruptures artistiques et culturels - EA 6301 ( InTRu ), Université de Tours, Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Institute of Parasitology, STAR laboratory, Stanford University [Stanford], Unité de recherche Virologie et Immunologie Moléculaires ( VIM ), Institut National de la Recherche Agronomique ( INRA ), Tennent Institute of Ophthalmology, National University of Singapore ( NUS ), Multidisciplinary Nanotechnology Centre, Swansea University, Department of Computer Sciences [Scheffield], University of Sheffield [Sheffield], Cyprus International Institute for the Environment and Public Health, Harvard School of Public Health, Glasgow Centre for Physical Organic Chemistry, University of Glasgow, King‘s College London, Université Panthéon-Sorbonne - UFR Science Politique ( UP1 UFR11 ), Université Panthéon-Sorbonne ( UP1 ), National Diagnostics Centre ( NDC ), National University of Ireland [Galway] ( NUI Galway ), Arthritis Research UK Epidemiology Unit ( MANCHESTER - Arthritis Research ), University of Manchester [Manchester], CEGOT - Porto, Universidade do Porto [Porto], Advanced Laboratories on Embedded Systems [Roma] ( ALES ), Department of Biology [Miami], University of Miami [Coral Gables], Division of Human Nutrition, Wageningen University and Research Centre [Wageningen] ( WUR ), Spatial Ecology and Epidemiology Group, University of Oxford [Oxford], Department of Civil Engineering [Hamirpur], National Institute of Technology [Hamirpur], GEMMA — Environmental Engineering and Microbiology Research Group, Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya [Barcelona] ( UPC ), Institut National de Recherche et d'Analyse Physico-Chimique ( INRAP ), Institut National de Recherche et d'Analyse Physico-chimique (INRAP-Tunisie), University of Connecticut ( UCONN ), Norwegian Institute for Air Research ( NILU ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) ( FEMTO-ST ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ), Tehran University, Friedrich-Alexander Universität Erlangen-Nürnberg ( FAU ), Secretariat of the Pacific Community, Public Health Division, Sociétés, Acteurs, Gouvernement en Europe ( SAGE ), Université de Strasbourg ( UNISTRA ) -Centre National de la Recherche Scientifique ( CNRS ), School of Physics and Astronomy, Washington State University ( WSU ), Laboratoire de Physique de l'ENS Lyon ( Phys-ENS ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en informatique de Toulouse ( IRIT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Toulouse 1 Capitole ( UT1 ) -Université Toulouse - Jean Jaurès ( UT2J ) -Université Toulouse III - Paul Sabatier ( UPS ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique ( CNRS ), School of Computer Science - China University of Geosciences (China University of Geosciences (East Area)), Université Catholique de Louvain ( UCL ), Div Cyclotron & Radiopharmaceut Sci ( DRDO, INMAS ), Univ New Delhi, University of St Andrews [Scotland], University of Cape Town, Department of Neuroscience, Karolinska Institutet [Stockholm], Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Computer Science and Engineering [Daejeon] (Chungnam National University), Lawrence University, Gastroenterology & Hepatology, Tata Research Development and Design Center ( TRDDC ), TCS Innovation Labs, Laboratoire MOLTECH-Anjou [Angers] ( MOLTECH ANJOU ), Université d'Angers ( UA ) -Centre National de la Recherche Scientifique ( CNRS ), University of Helsinki [Helsinki], Google Inc [Mountain View], Research at Google, Swedish Defense Research Agency ( FOI ), Centre de Recherche en Information Biomédicale sino-français ( CRIBS ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratory of Image Science and Technology [Nanjing] ( LIST ), Southeast University [Jiangsu]-School of Computer Science and Engineering, Laboratoire de glaciologie et géophysique de l'environnement ( LGGE ), Observatoire des Sciences de l'Univers de Grenoble ( OSUG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Centre National de la Recherche Scientifique ( CNRS ), School of Business and Informatics, University of Boras, Department of Mechanical and Automation Engineering ( CAD Laboratory ), The Chinese University of Hong Kong [Hong Kong], Università degli studi di Bari, Heuristique et Diagnostic des Systèmes Complexes [Compiègne] ( Heudiasyc ), Université de Technologie de Compiègne ( UTC ) -Centre National de la Recherche Scientifique ( CNRS ), Department of plant pathology and microbiology - centre for sustainable pest and disease management, Rothamsted Research, RGU, Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Barts and The London School of Medicine and Dentistry, Queen Mary University of London ( QMUL ), Centre d'économie de la Sorbonne ( CES ), Université Panthéon-Sorbonne ( UP1 ) -Centre National de la Recherche Scientifique ( CNRS ), Paris School of Economics ( PSE ), Istituto Dalle Molle di Studi sull'Intelligenza Artificiale ( IDSIA ), Università della Svizzera italiana ( USI ) -Scuola universitaria professionale della Svizzera italiana [Manno] ( SUPSI ), Anaesthetics, Southampton University Hospital, Department of Mathematics, University of Iowa [Iowa City], College of Medicine, Alfaisal University, Saudi Ministry of Health, Institut national des recherches agricoles du Bénin, Centre de Recherches agricoles du Sud, Departments of Epidemiology and Nutrition, Unit of Human Nutrition, Agricultural University of Athens, Department of Animal Science, PennState University [Pennsylvania] ( PSU ), University of Virginia, University of Virginia [Charlottesville], Epidemiology and Biostatistics Unit, Institute for Maternal and Child Health - IRCCS ‘‘Burlo Garofolo', Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), Division of Cardiovascular Medicine and Channing Division of Network Medicine, Brigham and Women's Hospital [Boston], Division of Gastroenterology and Hepatology, Department of Immunology, Mayo Clinic, Department of Chemistry, Scientific Computing Research Unit, Department of dermatology, Milano University-Azienda Ospedaleria Ospedali Riuniti di Bergamo, Department of epidemiology and Public Health, Faculty of Medicine, Hong Kong Baptist University ( HKBU ), Département Optique ( OPT ), Université européenne de Bretagne ( UEB ) -Télécom Bretagne-Institut Mines-Télécom [Paris], Department of Neurology Lunds University Hospital Lund, Services répartis, Architectures, MOdélisation, Validation, Administration des Réseaux ( SAMOVAR ), Institut Mines-Télécom [Paris]-Télécom SudParis ( TSP ) -Centre National de la Recherche Scientifique ( CNRS ), Département Réseaux et Services Multimédia Mobiles ( RS2M ), Institut Mines-Télécom [Paris]-Télécom SudParis ( TSP ), Electrical Engineering and Computer Science Department - Case Western Reserve University, Case Western Reserve University [Cleveland], Institut Lumière Matière [Villeurbanne] ( ILM ), Université Claude Bernard Lyon 1 ( UCBL ), World Health Organization, Nordic School of Public Health, The James Hutton Institute, Sero, Sero consulting, Evolutionary Ecology of Infectious Disease Group, Department of Zoology, Horia Hulubei National Institute for Physics and Nuclear Engineering, Dunedin School of Medicine, University of Otago, Department of Physics, Clarendon Laboratory, Center for TeleInFrastruktur ( CTIF ), Aalborg University [Denmark] ( AAU ), Physikalisches Institut [Freiburg], Albert-Ludwigs-Universität Freiburg, Savoirs, Textes, Langage (STL) - UMR 8163 ( STL ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Dept.of Computer Science, Indian Institute of Technology Madras ( IIT Madras ), Istituto Mario Negri Bergamo, Centro Ricerche e Trapianti Villa Camozzi, Universidade Estadual Paulista Júlio de Mesquita ( UNESP ), Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Université Grenoble Alpes - UFR Médecine ( UGA UFRM ), Université Grenoble Alpes ( UGA ), Clinical Epidemiology and Aging Research, German Cancer Research Center, Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Symantec, European Microsoft Innovation Center ( EMIC ), Microsoft Corporation [Redmond, Wash.], Laboratoire de Mécanique, Physique et Géosciences ( LMPG ), Université Le Havre Normandie ( ULH ), Normandie Université ( NU ) -Normandie Université ( NU ), Novartis institute for tropical diseases, Institut de Génétique et de Biologie Moléculaire et Cellulaire ( IGBMC ), Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Departments of Anatomy and Cell Biology, Wayne State University School of Medicine, Departments of Ophthalmology, Departments of Applied Physics [New Haven], Yale University [New Haven], Center for Mathematical Modeling ( CMM ), Universidad de Santiago de Chile [Santiago] ( USACH ), Laboratory for Atmospheric and Space Physics [Boulder] ( LASP ), University of Colorado Boulder [Boulder], University of Occupational and Environmental Health [Kitakyushu] ( UEOH ), Department of Computer Science and Engineering [New Delhi], Indian Institute of Technology Delhi ( IIT Delhi ), Institut de Recherche sur les Phénomènes Hors Equilibre ( IRPHE ), Aix Marseille Université ( AMU ) -Ecole Centrale de Marseille ( ECM ) -Centre National de la Recherche Scientifique ( CNRS ), GlaxoSmithKline, Imperial College London-Clinical Imaging Center, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, Yale School of Medicine-Yale School of Medicine-Yale Stem Cell Center, Maclean Building, Benson Lane, Crowmarsh Gifford, Centre for Ecology and Hydrology, Nanoscience Institute ( NEST ), Dipartimento di Fisica, Università di Pisa, Aristotle University of Thessaloniki, Laboratory Of Immune Cell Biology ( LICB ), National Institutes of Health ( NIH ), Institute of Human Genetics, Bonn Universität [Bonn], Occupational Health Unit, Bologna University Hospital-Sant'Orsola-Malpighi Polyclinic, Royal Institute of Technology [Stockholm] ( KTH ), Institut für Informatik [München/Munich] ( LMU ), Ludwig-Maximilians-Universität München, NICTA [Eveleigh], National ICT Australia [Sydney] ( NICTA ), Manchester Academic Health Sciences Centre, Institut d'Histoire et de Philosophie des Sciences et des Techniques ( IHPST ), Université Panthéon-Sorbonne ( UP1 ) -Département d'Etudes Cognitives - ENS Paris ( DEC ), École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris ) -Centre National de la Recherche Scientifique ( CNRS ), Ghent University [Belgium] ( UGENT ), German Research Centre for Geosciences - Helmholtz-Centre Potsdam ( GFZ ), Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique ( LHEEA ), École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche en Génie Civil et Mécanique ( GeM ), Université de Nantes ( UN ) -École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Neurorestoration Group, King‘s College London-Wolfson Centre for Age-related Diseases, Department of Computer Science [KAIST] ( CS ), Korea Advanced Institute of Science and Technology ( KAIST ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Natl Engn Res Ctr Vegetables, Key Lab Biol & Genet Improvement Hort Crops N Chi, Beijing Acad Agr & Forestry Sci, University Hospital Puerta de Hierro, Madrid, Computational Science and Engineering Department [Daresbury] (STFC), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Weill Cornell Medicine [Qatar], Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Centro de Estudios Avanzados en Zonas Aridas (CEAZA), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratoire d'Ingénierie des Matériaux (LIM), Centre National de la Recherche Scientifique (CNRS), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Samsung Research &Development Institute India - Bangalore (Groupe Samsung) (SRI-B), Multimedia Research Center (MRC), University of Alberta, Division of Biostatistics (Biostat - MINNEAPOLIS), University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, University of Southampton, University of Cambridge [UK] (CAM), Interactions, transferts, ruptures artistiques et culturels - EA 6301 (InTRu), Université de Tours (UT), Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Stanford University, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), National University of Singapore (NUS), Université Paris 1 Panthéon-Sorbonne - UFR Science Politique (UP1 UFR11), Université Paris 1 Panthéon-Sorbonne (UP1), National Diagnostics Centre (NDC), National University of Ireland [Galway] (NUI Galway), Arthritis Research UK Epidemiology Unit (MANCHESTER - Arthritis Research), Universidade do Porto = University of Porto, Advanced Laboratories on Embedded Systems [Roma] (ALES), Wageningen University and Research [Wageningen] (WUR), University of Oxford, Universitat Politècnica de Catalunya [Barcelona] (UPC), Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), University of Connecticut (UCONN), Norwegian Institute for Air Research (NILU), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Tehran, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Sociétés, Acteurs, Gouvernement en Europe (SAGE), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The George Washington University (GW), Washington State University (WSU), Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Université Catholique de Louvain = Catholic University of Louvain (UCL), Div Cyclotron & Radiopharmaceut Sci (DRDO, INMAS), School of Physics and Astronomy [St Andrews], Tata Research Development and Design Center (TRDDC), MOLTECH-Anjou, Université d'Angers (UA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Swedish Defense Research Agency (FOI), Centre de Recherche en Information Biomédicale sino-français (CRIBS), Université de Rennes (UR)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratory of Image Science and Technology [Nanjing] (LIST), Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Mechanical and Automation Engineering (CAD Laboratory), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Heuristique et Diagnostic des Systèmes Complexes [Compiègne] (Heudiasyc), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Biotechnology and Biological Sciences Research Council (BBSRC)-Biotechnology and Biological Sciences Research Council (BBSRC), Queen Mary University of London (QMUL), Centre d'économie de la Sorbonne (CES), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), Université Paris 1 Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA), Università della Svizzera italiana = University of Italian Switzerland (USI)-Scuola universitaria professionale della Svizzera italiana = University of Applied Sciences and Arts of Southern Switzerland [Manno] (SUPSI), Pennsylvania State University (Penn State), Penn State System-Penn State System, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Hong Kong Baptist University (HKBU), Département Optique (OPT), Université européenne de Bretagne - European University of Brittany (UEB)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT), Services répartis, Architectures, MOdélisation, Validation, Administration des Réseaux (SAMOVAR), Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP), Département Réseaux et Services Multimédia Mobiles (TSP - RS2M), University of Melbourne, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Otago [Dunedin, Nouvelle-Zélande], Center for TeleInFrastruktur (CTIF), Aalborg University [Denmark] (AAU), Savoirs, Textes, Langage (STL) - UMR 8163 (STL), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Indian Institute of Technology Madras (IIT Madras), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Microsoft Innovation Center (EMIC), Laboratoire de Mécanique, Physique et Géosciences (LMPG), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU), Novartis Institute for Tropical Diseases (NITD), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Center for Mathematical Modeling (CMM), Universidad de Chile = University of Chile [Santiago] (UCHILE), Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], University of Occupational and Environmental Health [Kitakyushu] (UEOH), Indian Institute of Technology Delhi (IIT Delhi), Institut de Recherche sur les Phénomènes Hors Equilibre (IRPHE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Yale University [New Haven]-Yale School of Medicine [New Haven, Connecticut] (YSM), Nanoscience Institute (NEST), University of Pisa - Università di Pisa, Laboratory Of Immune Cell Biology (LICB), National Institutes of Health [Bethesda] (NIH), Rheinische Friedrich-Wilhelms-Universität Bonn, Royal Institute of Technology [Stockholm] (KTH ), Institut für Informatik [München/Munich] (LMU), Ludwig-Maximilians-Universität München (LMU), National ICT Australia [Sydney] (NICTA), Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), Université Paris 1 Panthéon-Sorbonne (UP1)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Universiteit Gent = Ghent University (UGENT), German Research Centre for Geosciences - Helmholtz-Centre Potsdam (GFZ), Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Génie Civil et Mécanique (GeM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Department of Computer Science [KAIST] (CS), Korea Advanced Institute of Science and Technology (KAIST), Kardiyoloji, Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Minnesota [Twin Cities], Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Unité de recherche Virologie et Immunologie Moléculaires (VIM), Université Panthéon-Sorbonne - UFR Science Politique (UP1 UFR11), Université Panthéon-Sorbonne (UP1), Wageningen University and Research Centre [Wageningen] (WUR), Institut National de Recherche et d'Analyse Physico-chimique (Ariana, Tunisie) (INRAP), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), George Washington University (GW), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université Toulouse 1 Capitole (UT1)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Catholique de Louvain (UCL), MOLTECH-ANJOU (MOLTECH-ANJOU), Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), University of Helsinki, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Southeast University [Jiangsu]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Università della Svizzera italiana (USI)-Scuola universitaria professionale della Svizzera italiana [Manno] (SUPSI), California Institute of Technology (CALTECH)-NASA, Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP)-Centre National de la Recherche Scientifique (CNRS), Département Réseaux et Services Multimédia Mobiles (RS2M), Universidade Estadual Paulista Júlio de Mesquita Filho [São José do Rio Preto] (UNESP), Université Grenoble Alpes (UGA), Universidad de Santiago de Chile [Santiago] (USACH), Yale University [New Haven]-Yale University School of Medicine, Université Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Ghent University [Belgium] (UGENT), Université de Nantes - Faculté des Sciences et des Techniques, Grelier, Elisabeth, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Universidade do Porto, Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Toulouse 1 Capitole (UT1), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Università degli studi di Bari Aldo Moro (UNIBA), École des Ponts ParisTech (ENPC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università della Svizzera italiana = University of Italian Switzerland (USI)-Scuola universitaria professionale della Svizzera italiana [Manno] (SUPSI), Institut Mines-Télécom [Paris] (IMT)-Télécom Bretagne-Université européenne de Bretagne - European University of Brittany (UEB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Universiteit Gent = Ghent University [Belgium] (UGENT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-CHU Limoges-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM), Institut de Chimie du CNRS (INC)-Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Nantes (ECN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Wolfson Centre for Age-related Diseases-King‘s College London, Cell biology, Public Health, Epidemiology, Health Technology Assessment (HTA), Erasmus MC other, Pathology, and Cardiothoracic Surgery
Subjects: Gerontology, Male, CHANGING RELATION, Nutrition and Disease, MESH : Life Expectancy, MESH : Aged, ECONOMIC-DEVELOPMENT, Poison control, MESH: Global Health, Global Health, Socioeconomic Factor, Communicable Disease, MESH : Chronic Disease, Health Transition, Voeding en Ziekte, Quality-Adjusted Life Year, SELF-RATED HEALTH, MESH : Socioeconomic Factors, Medicine, MESH : Female, MESH: Mortality, Premature, 2. Zero hunger, MESH: Aged, education.field_of_study, MESH: Middle Aged, Mortality rate, Medicine (all), GBD2013 diseases, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, Middle Aged, 3. Good health, MESH : Wounds and Injuries, Epidemiological transition, MESH: Quality-Adjusted Life Years, MESH: Communicable Diseases, NONCOMMUNICABLE DISEASES, Female, Quality-Adjusted Life Years, MESH: Life Expectancy, MESH: Health Transition, Human, MESH: Socioeconomic Factors, ACUTE MYOCARDIAL-INFARCTION, MESH : Male, MORTALITY TRENDS, Population, MESH : Health Transition, Communicable Diseases, Article, Life Expectancy, EUROPEAN-UNION, SDG 3 - Good Health and Well-being, General & Internal Medicine, SYSTEMATIC ANALYSIS, Disability-adjusted life year, Humans, Life Science, MESH : Middle Aged, Mortality, education, Premature, MESH : Mortality, Premature, VLAG, Aged, MESH: Humans, business.industry, Mortality, Premature, MESH: Chronic Disease, MESH : Communicable Diseases, Wounds and Injurie, MESH : Humans, MESH : Quality-Adjusted Life Years, Non-communicable disease, Chronic Disease, Socioeconomic Factors, Wounds and Injuries, medicine.disease, MESH: Male, LOW SOCIOECONOMIC-STATUS, Years of potential life lost, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Wounds and Injuries, Life expectancy, RISK-FACTORS, MESH : Global Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age–sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. Methods We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. Findings Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6–6·6), from 65·3 years (65·0–65·6) in 1990 to 71·5 years (71·0–71·9) in 2013, HALE at birth rose by 5·4 years (4·9–5·8), from 56·9 years (54·5–59·1) to 62·3 years (59·7–64·8), total DALYs fell by 3·6% (0·3–7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6–29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non–communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries. Interpretation Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition—in which increasing sociodemographic status brings structured change in disease burden—is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions. Funding Bill & Melinda Gates Foundation. BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. METHODS: We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. FINDINGS: Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0·3-7·4), and age-standardised DALY rates per 100 000 people fell by 26·7% (24·6-29·1). For communicable, maternal, neonatal, and nutritional disorders, global DALY numbers, crude rates, and age-standardised rates have all declined between 1990 and 2013, whereas for non-communicable diseases, global DALYs have been increasing, DALY rates have remained nearly constant, and age-standardised DALY rates declined during the same period. From 2005 to 2013, the number of DALYs increased for most specific non-communicable diseases, including cardiovascular diseases and neoplasms, in addition to dengue, food-borne trematodes, and leishmaniasis; DALYs decreased for nearly all other causes. By 2013, the five leading causes of DALYs were ischaemic heart disease, lower respiratory infections, cerebrovascular disease, low back and neck pain, and road injuries. Sociodemographic status explained more than 50% of the variance between countries and over time for diarrhoea, lower respiratory infections, and other common infectious diseases; maternal disorders; neonatal disorders; nutritional deficiencies; other communicable, maternal, neonatal, and nutritional diseases; musculoskeletal disorders; and other non-communicable diseases. However, sociodemographic status explained less than 10% of the variance in DALY rates for cardiovascular diseases; chronic respiratory diseases; cirrhosis; diabetes, urogenital, blood, and endocrine diseases; unintentional injuries; and self-harm and interpersonal violence. Predictably, increased sociodemographic status was associated with a shift in burden from YLLs to YLDs, driven by declines in YLLs and increases in YLDs from musculoskeletal disorders, neurological disorders, and mental and substance use disorders. In most country-specific estimates, the increase in life expectancy was greater than that in HALE. Leading causes of DALYs are highly variable across countries. INTERPRETATION: Global health is improving. Population growth and ageing have driven up numbers of DALYs, but crude rates have remained relatively constant, showing that progress in health does not mean fewer demands on health systems. The notion of an epidemiological transition-in which increasing sociodemographic status brings structured change in disease burden-is useful, but there is tremendous variation in burden of disease that is not associated with sociodemographic status. This further underscores the need for country-specific assessments of DALYs and HALE to appropriately inform health policy decisions and attendant actions. FUNDING: Bill & Melinda Gates Foundation.
Published: 2015

95. Cohort Profile: The Cohorts Consortium of Latin America and the Caribbean (CC-LAC)

Author: Leila Beltrami Moreira, Betty S Manrique-Espinoza, Elard Koch, Dalia Stern, Catterina Ferreccio, Claudia Bambs, Adrian Cortes-Valencia, Ione Jayce Ceola Schneider, Marselle B Amadio, José Geraldo Mill, José Boggia, Gilbert Brenes-Camacho, Lariane M Ono, Alvaro Cc Maciel, Walter G Espeche, Poli Mara Spritzer, Fernando Luiz Herkenhoff, J. Jaime Miranda, Adolfo Rubinstein, Horacio A Carbajal, Cecilia Baccino, Andrea R. V. R. Horimoto, Anselm Hennis, Gonzalo Grazioli, Mariachiara Di Cesare, Katia Vergetti Bloch, Ricardo Oliveira Guerra, Gloria L. Beckles, João Luiz Bastos, Álvaro Ruiz-Morales, Alexandre C. Pereira, Ramon A Sanchez, Fiorella Tartaglione, Antonio Bernabe-Ortiz, Roberto de Sa Cunha, Luis Rosero-Bixby, Vilma Irazola, Rodrigo M. Carrillo-Larco, Martin R Salazar, Thiago L N Silva, Pollyanna Kássia de Oliveira Borges, Ian Hambleton, Juan E. Blümel, Flávio Danni Fuchs, Aaron Salinas-Rodriguez, Ramón Álvarez-Vaz, Eleonora d'Orsi, David Alejandro González-Chica, Paulo A. Lotufo, Sérgio Viana Peixoto, Sandra Cortés, Goodarz Danaei, Rosalba Rojas-Martínez, Suely Godoy Agostinho Gimeno, Karen Glazer Peres, Jackie A. Cooper, Maria Fernanda Lima-Costa, Larissa Pruner Marques, Marco Aurélio Peres, Nohora I Rodriguez, William H. Dow, Edward W. Gregg, Laura Gutierrez, Clicerio González-Villalpando, Liam Smeeth, Jorge Tartaglione, Miguel Bravo, Oscar Muñoz, Maria S. Castillo Rascon, Karen Oppermann, María-Elena González-Villalpando, Blanca H. Ceballos, Susana Cararo Confortin, Ruy Lopez-Ridaura, Majid Ezzati, Andrea Huidobro, Carlos A. Aguilar-Salinas, Verônica Colpani, Sandra C. Fuchs, Nelson A S Silva, Donaji Gomez-Velasco, Pablo Perel, Martin Lajous, and Carla de Oliveira Bernardo
Subjects: 0301 basic medicine, medicine.medical_specialty, Framingham Risk Score, Latin Americans, Epidemiology, business.industry, General Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Health care, Cohort, Global health, Medicine, AcademicSubjects/MED00860, 030212 general & internal medicine, business, Cohort Profiles, Disease burden, Demography, Cohort study
Abstract: Why was the cohort set up? Latin America and the Caribbean (LAC) are characterized by much diversity in terms of socio-economic status, ecology, environment, access to health care,1,2 as well as the frequency of risk factors for and prevalence or incidence of non-communicable diseases;3–7 importantly, these differences are observed both between and within countries in LAC.8,9 LAC countries share a large burden of non-communicable (e.g. diabetes and hypertension) and cardiovascular (e.g. ischaemic heart disease) diseases, with these conditions standing as the leading causes of morbidity, disability and mortality in most of LAC.10–12 These epidemiological estimates—e.g. morbidity—cannot inform about risk factors or risk prediction, which are relevant to identify prevention avenues. Cohort studies, on the other hand, could provide this evidence. Pooled analysis, using data from multiple cohort studies, have additional strengths such as increased statistical power and decreased statistical uncertainty.13 LAC cohort studies have been under-represented,14 or not included at all,15–17 in international efforts aimed at pooling data from multiple cohort studies. We therefore set out to pool data from LAC cohorts to address research questions that individual cohort studies would not be able to answer. Drawing from previous successful regional enterprises (e.g. Asia Pacific Cohort Studies Collaboration),18,19 we established the Cohorts Consortium of Latin America and the Caribbean (CC-LAC). The main aim of the CC-LAC is to start a collaborative cohort data pooling in LAC to examine the association between cardio-metabolic risk factors (e.g. blood pressure, glucose and lipids) and non-fatal and fatal cardiovascular outcomes (e.g. stroke or myocardial infarction). In so doing, we aim to provide regional risk estimates to inform disease burden metrics, as well as other ambitious projects including a cardiovascular risk score to strengthen cardiovascular prevention in LAC. Initial funding has been provided by a fellowship from the Wellcome Trust Centre for Global Health Research at Imperial College London (Strategic Award, Wellcome Trust–Imperial College Centre for Global Health Research, 100693/Z/12/Z). Additional funding is being provided by an International Training Fellowship from the Wellcome Trust (214185/Z/18/Z). At the time of writing, the daily operations and pooled database are hosted at Imperial College London, though a mid-term goal is to transfer this expertise and operations to LAC. The collaboration relies fundamentally on a strong regional network of health researchers and practitioners
Published: 2020

96. Mortalidad prematura por las principales enfermedades crónicas no transmisibles en los estados de Brasil

Author: Ione Jayce Ceola Schneider, Aline Rodrigues Barbosa, Vandrize Meneghini, Viviana Mariá Draeger, Susana Cararo Confortin, and Selma Regina de Andrade
Subjects: Adult, Male, medicine.medical_specialty, Estudos Ecológicos, RT1-120, Estudios Ecológicos, Geographic Mapping, Nursing, Salud Pública, Saúde Pública, Enfermedad Crónica, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Diabetes mellitus, Medicine, Humans, 030212 general & internal medicine, Mortality, Mortality trends, Noncommunicable Diseases, General Nursing, Doença Crônica, Aged, 030505 public health, business.industry, Mortality, Premature, Public health, Mortality rate, Ecological Studies, Age Factors, Ecological study, Mortalidad Prematura, Middle Aged, medicine.disease, Chronic disease, Enfermedades no Transmisibles, Chronic Disease, Female, Morte Prematura, Public Health, Doenças Não Transmissíveis, 0305 other medical science, business, Brazil
Abstract: Objective: To verify the variation of the premature mortality rate caused the group of the main chronic noncommunicable diseases. Method: This is a time-series ecological study, which used secondary data of the Mortality Information System, from 2006 to 2014, from the 26 federal units and from the Federal District. Deaths caused by circulatory system diseases, cancer, diabetes and chronic respiratory diseases were included. The trend of adjusted mortality rate was analyzed by segmented linear regression. Results: Premature mortality tended to be reduced in most states, except for Maranhão and Rio Grande do Norte, which presented a stable premature mortality rate. Bahia, Pernambuco, Sergipe, Roraima and all the states from the South, Southeast and Central-West Regions reached the goal of reducing 2% per year in premature mortality caused by main diseases. Conclusion: Most of the states showed a reduced mortality rate and are reaching the proposed target. RESUMEN Objetivo: Verificar la variación de la tasa de mortalidad prematura por el conjunto de las principales enfermedades crónicas no transmisibles. Método: Estudio ecológico de series temporales, en que se utilizaron datos secundarios del Sistema de Información sobre Mortalidad, de 2006 a 2014, de las 26 Unidades Federativas y del Distrito Federal. Se incluyeron muertes con causa básica las enfermedades del aparato circulatorio, cáncer, diabetes y enfermedades respiratorias crónicas. La tendencia de la tasa ajustada de mortalidad se analizó por la regresión lineal segmentada. Resultados: Hubo tendencia de reducción de la mortalidad prematura en la mayoría de los estados, excepto Maranhão y Rio Grande do Norte que presentaron estabilidad de la tasa de mortalidad prematura. Los estados de Bahía, Pernambuco, Sergipe, Roraima y todos de la Región Sur, Sudeste y Centro-Oeste alcanzaron la meta de reducción del 2% al año en la mortalidad prematura por las principales enfermedades. Conclusión: La mayoría de los estados presentan reducción de la tasa de mortalidad y están alcanzando la meta propuesta. RESUMO Objetivo: Verificar a variação da taxa de mortalidade prematura pelo conjunto das principais doenças crônicas não transmissíveis. Método: Estudo ecológico de séries temporais, que utilizou dados secundários do Sistema de Informações sobre Mortalidade, de 2006 a 2014, das 26 unidades federativas e do Distrito Federal. Foram incluídos óbitos que tiveram como causa básica doenças do aparelho circulatório, câncer, diabetes e doenças respiratórias crônicas. A tendência da taxa ajustada de mortalidade foi analisada pela regressão linear segmentada. Resultados: Houve tendência de redução da mortalidade prematura na maioria dos estados, exceto Maranhão e Rio Grande do Norte, que apresentaram estabilidade da taxa de mortalidade prematura. Os estados da Bahia, Pernambuco, Sergipe, Roraima e todos das regiões Sul, Sudeste e Centro-Oeste atingiram a meta de redução de 2% ao ano na mortalidade prematura pelas principais doenças. Conclusão: A maioria dos estados apresentaram redução da taxa de mortalidade e estão atingindo a meta proposta.
Published: 2018

97. Fatores sociodemográficos, comportamentais e de saúde associados à autopercepção de saúde positiva de idosos longevos residentes em Florianópolis, Santa Catarina

Author: Maruí Weber Corseuil Giehl, Rodrigo de Rosso Krug, Danielle Ledur Antes, André Junqueira Xavier, Giovana Zarpellon Mazo, Eleonora d'Orsi, Ione Jayce Ceola Schneider, and Susana Cararo Confortin
Subjects: Gerontology, Tratamento, Epidemiology, Comorbidade, Comorbidity, Saúde, Estilo de vida, 03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, Self report, 030505 public health, Life style, lcsh:Public aspects of medicine, Autoavaliação, Public Health, Environmental and Occupational Health, Self perceived health, lcsh:RA1-1270, General Medicine, Treatment, Elderly people aged 80 and older, Self-assessment, Health, Idosos de 80 anos ou mais, 0305 other medical science, Psychology
Abstract: RESUMO: O objetivo deste estudo foi verificar os fatores associados à autopercepção de saúde positiva de idosos longevos (80+). Estudo transversal conduzido no município de Florianópolis, Santa Catarina, Brasil, com 239 idosos participantes do EpiFloripa Idoso. Foram aplicados instrumentos de coleta para verificar dados sociodemográficos e econômicos, autorrelato do estado de saúde, quedas e estilo de vida. Para identificar os fatores associados à autopercepção de saúde positiva, utilizou-se regressão de Poisson ajustada por sexo. A autopercepção de saúde positiva foi mais prevalente nos idosos longevos sem a presença de depressão (RP = 0,49) e que faziam consumo de álcool (RP = 1,99). Compreender quais variáveis podem interferir na autopercepção de saúde de idosos longevos auxilia em melhores ações de saúde para essa população, principalmente para evitar depressão, além de reduzir custos com internações, medicamentos e tratamentos de saúde, muito frequentes em idosos longevos.
Published: 2018

98. Effects of using lubricant during the speculum examination for Pap smear collection

Author: Jefferson Traebert, Ione Jayce Ceola Schneider, Rodrigo Dias Nunes, and Maisa Cascaes
Subjects: Adult, Gynecological examination, Histology, Efficacy, Adolescent, Dentistry, Uterine Cervical Neoplasms, Pathology and Forensic Medicine, 03 medical and health sciences, Vaginal Lubricant, Young Adult, 0302 clinical medicine, Cytology, Statistical significance, Medicine, Humans, Lubricants, Vaginal Smears, 030219 obstetrics & reproductive medicine, business.industry, Medical school, General Medicine, Odds ratio, Papanicolaou Test, Papanicolaou test, Surgical Instruments, Gynecological Examination, Confidence interval, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Female, business
Abstract: Objective: To evaluate the effect of using lubricant during speculum examination for Pap smear collection. Methods: A cross-sectional study was conducted involving 83 patients attending a medical school clinic. Participants were allocated into two groups: Group 1—Lubricant using; Group 2—No lubricant using. All patients were submitted to two successive collections and after were asked about their level of discomfort. Differences between groups regarding quality, artifacts, cytology, and level of discomfort were observed through chi-squared test. Odds ratios and 95% confidence intervals were also estimated. Statistical significance was set at P < .05. Results: No significant differences between groups regarding quality, presence of artifacts, and cytological results were observed. Significant lower discomfort level in Group 1 (lubricant using). Conclusion: The use of vaginal lubricant did not affect the results of cytology and could be a useful tool to reduce the discomfort during Pap smear collection.
Published: 2018

99. Tendência da carga da tuberculose em um estado do sul do Brasil

Author: Pamela Nogueira Silva Vilela, Eliane Traebert, Jefferson Traebert, and Ione Jayce Ceola Schneider
Subjects: Male, Epidemiology, Carga da doença, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Young adult, Child, Aged, 80 and over, lcsh:Public aspects of medicine, Age Factors, Burden of disease, General Medicine, Middle Aged, Impact, Child, Preschool, Disease Notification, Mortalidade, Female, 0305 other medical science, Brazil, Adult, medicine.medical_specialty, Tuberculosis, Adolescent, Developing country, Age and gender, Young Adult, 03 medical and health sciences, Age groups, Environmental health, Humans, Tuberculose, Disabled Persons, Mortality, Epidemiologia, Aged, Ambiente, 030505 public health, business.industry, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, medicine.disease, Morbidade, Epidemiologic Studies, Morbidity, business
Abstract: Introduction: The burden of tuberculosis has been scarcely explored in developing countries. Objective: To estimate the trend of the burden of tuberculosis in the state of Santa Catarina, southern Brazil, from 2007 to 2011. Methods: Epidemiological time-series study on tuberculosis notifications and deaths reported in the Disease Notification System and the Mortality Information System between 2007 and 2011. Crude rates of Disability-Adjusted Life Years (DALY) and subcomponents were calculated and standardized by gender and age groups. Segmented linear regression was used to estimate the trends for burden of tuberculosis during the study period. Results: There were 696 deaths and 8,598 notifications during the study period. The highest rate was found in 2009, with 91.8 DALY/100,000 inhabitants, and the lowest in 2007, with 67.2 DALY/100,000 inhabitants. The highest burden was among men in economically active age groups. The study showed a non-significant increase of 3.8% per year in DALY rates. Conclusion: The burden of tuberculosis remained stable in Santa Catarina, Brazil between 2007 and 2011. RESUMO: Introdução: A carga da tuberculose vem sendo pouco estudada nos países em desenvolvimento. Objetivo: Estimar a tendência da carga da tuberculose no estado de Santa Catarina no período de 2007 a 2011. Métodos: Estudo epidemiológico de séries temporais realizado com base em dados de óbitos e notificações por tuberculose reportadas no Sistema de Informação de Mortalidade e no Sistema de Informação de Agravos de Notificação dos residentes no estado de Santa Catarina entre 2007 e 2011. Taxas brutas de anos de vida perdidos ajustados por incapacidade (DALY) e seus subcomponentes foram calculadas e posteriormente padronizadas segundo sexo e faixas etárias. Foi feita análise de regressão linear segmentada para estimar a tendência da carga no período estudado. Resultados: Foram observados 696 óbitos e 8.598 notificações de tuberculose nos anos em estudo. A maior taxa deu-se no ano de 2009, com 91,8 DALY/100 mil habitantes, e a menor, no ano de 2007, com 67,2 DALY/100 mil habitantes. Maior carga de tuberculose foi verificada no sexo masculino e em faixas etárias economicamente ativas. Encontrou-se aumento não significativo de 3,8% ao ano nas taxas de DALY no estado no período estudado. Conclusão: A carga da tuberculose manteve-se estável em Santa Catarina entre 2007 e 2011.
Published: 2018

100. Condiciones vida y salud de adultos mayores: resultados del estudio de cohortes EpiFloripa Idoso

Author: Susana Cararo Confortin, Ione Jayce Ceola Schneider, Danielle Ledur Antes, Francieli Cembranel, Lariane Mortean Ono, Larissa Pruner Marques, Lucélia Justino Borges, Rodrigo de Rosso Krug, and Eleonora d’Orsi
Subjects: medicine.medical_specialty, Aging, Injury control, Accident prevention, Salud del Anciano, Anciano, Envejecimiento, Saúde do Idoso, lcsh:Medicine, Poison control, Estudos Longitudinais, 03 medical and health sciences, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Longitudinal Studies, Aged, Gynecology, 030505 public health, business.industry, Envelhecimento, lcsh:Public aspects of medicine, Idoso, lcsh:R, lcsh:RA1-1270, General Medicine, Estudios Longitudinales, Health of the Elderly, 0305 other medical science, business
Abstract: Resumo OBJETIVO: identificar as mudanças sociodemográficas, comportamentais e de saúde ocorridas ao longo do tempo nos participantes do estudo de coorte EpiFloripa Idoso. MÉTODOS: estudo longitudinal de base populacional com idosos de Florianópolis-SC, Brasil. RESULTADOS: entrevistou-se 1.702 idosos em 2009-2010 e 1.197 em 2013-2014 (proporções de resposta: 89,1% e 70,2%, respectivamente); após aproximadamente 4 anos, a maioria manteve-se com companheiro (53,4%), morando acompanhado (76,0%), sem trabalhar (78,0%), com percepção positiva de saúde (44,0%), sem usar internet (67,5%), sem fumar (57,5%), sem consumir bebida alcoólica (53,3%), insuficientemente ativo (56,3%), consumindo
Published: 2017

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