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10,355 results on '"Itoh T"'

53. Microwave-Photonics Systems

Author

Wake, D., Lane, P., Joindot, M., Cadiou, J. F., Jaffré, P., Pénard, E., Kalbe, G., Qian, Y., Deal, W. R., Itoh, T., Lee, J. J., Sparks, R. A., Chazelas, J., Dolfi, D., Daryoush, A. S., Vilcot, Anne, editor, Cabon, Béatrice, editor, and Chazelas, Jean, editor

Published
2003
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66. Caspase Recruitment Domain-Containing Protein 9 Expression is a Novel Prognostic Factor for Lung Adenocarcinoma

Author

Miwa N, Nagano T, Jimbo N, Dokuni R, Kiriu T, Mimura C, Yasuda Y, Katsurada M, Yamamoto M, Tachihara M, Tanaka Y, Kobayashi K, Itoh T, Maniwa Y, and Nishimura Y

Subjects
spiral array, immunohistochemistry, lung adenocarcinoma, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, card9
Abstract

Nanako Miwa,1 Tatsuya Nagano,1 Naoe Jimbo,2 Ryota Dokuni,1 Tatsunori Kiriu,1 Chihiro Mimura,1 Yuichiro Yasuda,1 Masahiro Katsurada,1 Masatsugu Yamamoto,1 Motoko Tachihara,1 Yugo Tanaka,3 Kazuyuki Kobayashi,1 Tomoo Itoh,2 Yoshimasa Maniwa,3 Yoshihiro Nishimura1 1Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan; 2Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; 3Division of Thoracic Surgery, Kobe University Graduate School of Medicine, Kobe, JapanCorrespondence: Tatsuya Nagano Tel +81 78 382 5660Fax +81 78 382 5661Email tnagano@med.kobe-u.ac.jpPurpose: Caspase recruitment domain-containing protein 9 (CARD9) is expressed at high levels in bone marrow cells and has a crucial role in innate immunity. Current studies indicate that CARD9 also plays a key role in tumor progression, but there are few reports on the role of CARD9 in lung cancer. The aim of this study was to clarify the role of CARD9 in lung adenocarcinoma.Patients and Methods: Lung adenocarcinoma tumor samples from 74 patients who underwent complete resection at Kobe University Hospital from January 2014 to December 2014 were analyzed by immunohistochemistry. The role of CARD9 in cancer cells was analyzed using lung cancer cell lines treated with CARD9 siRNA.Results: High expression of CARD9 was observed in 32.4% of tumors, and compared to low expression of CARD9, high expression was associated with poorer overall survival (P = 0.0365). Univariate and multivariate analyses showed that high expression of CARD9 was an independent prognostic factor. Knockdown of CARD9 in lung adenocarcinoma cells inhibited proliferation but did not increase apoptosis. In addition, CARD9 activated the NF-κB pathway in a lung adenocarcinoma cell line.Conclusion: CARD9 was shown to be an independent prognostic factor of poor outcome for lung cancer and may represent a molecular target for treatment.Keywords: CARD9, lung adenocarcinoma, spiral array, immunohistochemistry

Published
2020

85. Provably Secure Key-Updating Schemes in Identity-Based Systems

Author

Shinozaki, S., Itoh, T., Fujioka, A., Tsujii, S., Goos, G., editor, Hartmanis, J., editor, Barstow, D., editor, Brauer, W., editor, Hansen, P. Brinch, editor, Gries, D., editor, Luckham, D., editor, Moler, C., editor, Pnueli, A., editor, Seegmüller, G., editor, Stoer, J., editor, Wirth, N., editor, and Damgård, Ivan Bjerre, editor

Published
1991
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91. Pulmonary involvements of anti-neutrophil cytoplasmic autoantibody-associated renal vasculitis in Japan

Author

Hirayama, Kouichi, Kobayashi, Masaki, Usui, Joichi, Arimura, Yoshihiro, Sugiyama, Hitoshi, Nitta, Kosaku, Muso, Eri, Wada, Takashi, Matsuo, Seiichi, Yamagata, Kunihiro, Fujimoto, S., Hirawa, S., Horikoshi, S., Hosoya, T., Itoh, T., Inaguma, O., Kaname, S., Kawamura, T., Kimura, K., Maruyama, S., Nakabayashi, N., Ogura, M., Saitoh, T., Tabei, T., Taguma, Y., Tsuruya, K., Watanabe, T., Yasunaga, S., Yoshida, M., Yumura, W., Yuzawa, Y., and Sada, K.

Published
2015
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