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Investigators at the Taipei Medical University Hospital and other centers in Taiwan conducted a case-control study in 2002-2014 among 105 cases with phenytoin-related severe cutaneous adverse reactions (n = 61 Stevens-Johnson syndrome/toxic epidermal necrolysis and n = 44 drug reactions with eosinophilia and systemic symptoms), 78 cases with maculopapular exanthema, 130 phenytoin-tolerant control participants, and 3655 population controls from Taiwan, Japan, and Malaysia.

Investigators from the Children's Hospital of Philadelphia, PA, and McGill University, Montreal, Quebec, CA, report an adolescent learning-disabled girl who presented at age 14 years with an epilepsy syndrome initially diagnosed as juvenile myoclonic epilepsy.

Investigators at the National Institute of Mental Health, Bethesda, MD, compared the prevalence and clinical correlates of DSM-IV-TR versus DSM-5-defined ADHD and subtypes in a nationally representative sample of US youth based on age-of-onset criterion.

Investigators from Okazaki City Hospital, and other centers in Japan retrospectively evaluated the clinical features, ultrasonography, and EEG findings in 22 preterm infants with PVHI and 49 with PVL.

Investigators at Seoul National Hospital, and other centers in Seoul, Korea, studied the genetic, perinatal, and developmental risk factors in 147 children, ages 6 to 15 years, diagnosed with ADHD.

Investigators at University of Toronto, Canada, report detection of atypical (dysplastic) neuronal elements in 4 of 5 teratomas resected from cases with NMDAR encephalitis but not in 39 controls.

Investigators at Utrecht University, the Netherlands; and centers in Australia and Detroit, MI, evaluated the lapses of attention during on-road highway driving in 18 adult ADHD patients during treatment with methylphenidate (MPH) or placebo.

Investigators at the Boston Children's Hospital, MA, and other centers evaluated the role of copy number variants (CNVs) detected using chromosomal microarray (CMA) testing in 805 patients seen between 2006 and 2011 and having ICD-9 codes for epilepsy or seizures.

Investigators at Fujita University School of Medicine, Toyoake, Aichi, Japan, performed a nation-wide survey to determine the incidence and clinical features of rotavirus-associated encephalitis/encephalopathy (RV-AE) and sudden unexpected death (SUD) in Japan.

Investigators at University of Minnesota, Minneapolis, report cardiac autonomic dysfunction and arterial stiffness among children and adolescents with ADHD treated with stimulants.

Investigators at University of Columbo, Sri Lanka, studied the efficacy of oral prednisolone (40-60 mg/day) and intramuscular adrenocorticotrophin hormone (40-60 IU synthetic ACTH every other day) for 14 days in improving hypsarrhythmia in children (age 2 mos-2 yrs) with previously untreated West syndrome.

Investigators at the Research Institute Brainclinics, Nijmegen, Netherlands, conducted a meta-analysis on the Theta/Beta ratio (TBR) during Eyes Open from location Cz (the electrode halfway between the inion and the nasion) in the EEG of children/adolescents 6-18 years of age with and without ADHD.

Investigators at University of Gaziantep, Turkey, studied the frequency of celiac disease (CD) among children with occipital epilepsy.

Investigators at Bambino Genu Children's Hospital, Rome, and multiple additional centers in Italy conducted a retrospective and prospective study of clinical manifestations at diagnosis and during follow-up of 228 patients with 22q11.2 deletion syndrome.

Investigators at the University of Queensland, Brisbane, Australia, and the University of California, Benioff Children's Hospital, studied the clinical features of syndromes associated with agenesis of the corpus callosum (ACC) and their relation to the genetic causes and developmental processes involved.

Investigators at Erasmus MC, Rotterdam, The Netherlands, evaluated the 2012 revised IPMSSG consensus definitions in a cohort of children with acquired demyelinating syndromes (ADS) prospectively followed for 2 years from Jan 2007.

Investigators at Boston Children's Hospital and at University of Florida, Gainesville, studied the comparative efficacy of plasmapheresis (PLEX) vs immunoglobulin (IVIG) as maintenance therapy in juvenile myasthenia gravis (MG).

Investigators at University of California, San Francisco, and other centers, report a case of leptospirosis in a 14-year-old boy with severe combined immunodeficiency.

Investigators at University Hospital, Zurich, Switzerland, and multiple centers in Europe and Canada, sequenced the pyridoxal 5-phosphate oxidase (PNPO) gene in 31 patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene.

Investigators from University of California, San Diego, and other centers in the US, assayed markers for neurons and glia and genes implicated in the risk of autism, in prefrontal, temporal, and occipital neocortex.

Investigators at the Division of Emergency Medicine, Children's National Medical Center, Washington, DC, and ten additional US centers in the Pediatric Emergency Care Applied Research Network (PECARN), conducted a double-blind, randomized clinical trial comparing the efficacy and safety of lorazepam and diazepam in the treatment of generalized convulsive status epilepticus (SE) in children aged 3 months to younger than 18 years.

Investigators at University of Toronto and McMaster University, Canada, report a 22-year-old woman with multiple episodes of status epilepticus and migratory cortical stroke-like lesions.

Investigators from the Epilepsy Center, Lurie Children's Hospital of Chicago, and Yale School of Medicine, New Haven, CT, examined the possible association between long-term seizure outcome of childhood absence epilepsy (CAE) and the initial treatment with ethosuximide (ESM) or valproic acid (VPA).

Investigators from Taichung, Taiwan, conducted a nationwide population-based retrospective study of the association between febrile seizure (FS) and allergic rhinitis.

Investigators at King Abdulaziz University, Jeddah, Saudi Arabia, report their experience with IV pulse methylprednisolone in the treatment of children with severe drug-resistant epilepsy.

Investigators at the National Institute of Mental Health and Neurosciences, Bangalore, India, conducted a retrospective analysis of semiologic patterns of psychogenic non-epileptic seizures (PNES) diagnosed by video EEG in 56 children aged < 18 years (mean age 12.3 yrs; range 2-17 yrs).

Investigators at University of Texas Southwestern Medical Center, Dallas, TX, report 2 male patients, an infant and adult, with confirmed herpes simplex encephalitis (HSE) and anti-NMDA receptor antibody encephalitis.

Investigators from the Oncology Unit, Royal Children's Hospital, Melbourne, Australia, compared the frequency of headache and procedure time following lumbar puncture (LP) in a randomized crossover trial using a 25-gauge compared to a 22-gauge needle.

Investigators at Danish Headache Centre, University of Copenhagen, Glostrup, Denmark, studied the incidence of migraine during and after intravenous infusion of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide (VIP) in 22 female migraine patients without aura (mean age 24 years [range 19-36]).

Investigators from National University Hospital, Singapore, review the clinical features of 13 cases of pharyngeal-cervical-brachial (PCB) variant of Guillain-Barre syndrome (GBS) and outline new diagnostic criteria.

Investigators at Leiden University Medical Centre, The Netherlands, studied the symptoms, video data of signs, and EEG changes during tilt-induced vasovagal syncope in 69 subjects, age range 12-84 years (mean 46 years).

Researchers in Chang Gung University, Kaohsiung, and National Cheng Kung University, Tainan, Taiwan, assessed the prevalence and spectrum of paraneoplastic neurological disorders (PND) in children with benign ovarian tumor and the long-term outcome.

Investigators at Montreal Neurological Institute and Hospital, Canada, studied intracranial electroencephalographic seizure-onset patterns associated with different epileptogenic lesions, and defined high-frequency oscillation correlates of each pattern.

Investigators at Queen Mary Hospital, Hong Kong, report a case of Ohtahara syndrome with transient folinic acid responsiveness but without evidence of antiquitin dysfunction in a girl later found to have a known STXBP1 mutation.

Investigators from Albert Einstein College of Medicine, Bronx, NY, recorded the gait characteristics and prevalence of toe walking, the range of passive joint mobility, and age at walking in children with DSM IV autism spectrum disorders (ASDs) and in age- and gender-matched healthy peers (mean age 4 years 6 months, range 22 months – 10 years 9 months).

Investigators from Aristotle University of Thessaloniki, Greece, identified prognostic factors for subsequent epilepsy in a prospective study of 501 children with a first febrile seizure (FS).

Investigators at Children's Hospital of Pittsburgh, PA; UCLA; and Univ Wisconsin, Madison, WI, draw attention to the lack of attention to comorbidities in the treatment of epilepsy.

Investigators at Wakayama Medical University, Japan, report the neuroimaging features soon after birth in 2 siblings with molybdenum cofactor deficiency (MoCoD) type A.

Investigators at Brown University, Providence, RI, and other imaging genetic centers in the US, compare MRI measurements of white matter myelin water fraction (MWF) and gray matter volume (GMV) in healthy infant carriers and noncarriers of the apolipoprotein E (APOE) e4 allele, the major susceptibility gene for late-onset Alzheimer disease (AD).

Investigators from Baylor College of Medicine, Texas Children's Hospital, Houston, TX; Kennedy Krieger Institute, Baltimore, MD; and University of Minnesota, MN, report 3 patients from 2 unrelated families with a complex neuropathy phenotype characterized by axonal sensorimotor neuropathy, severe nonprogressive microcephaly and cerebral dysgenesis

Epileptologists from the Case Medical Center, Cleveland, Ohio; and the Comprehensive Epilepsy Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, are guest editors of the December 2013 Epilepsia Supplement on Tumors and Tumoral Epilepsy.

Investigators from Mayo Clinic, Rochester, MN, retrospectively identified 13 patients with type II Alexander disease (AxD) evaluated from Jan 1996 to Feb 2012.

Investigators from Great Ormond Street Hospital, and Institute of Child Health, London, UK, reviewed the case notes of all patients treated with methylphenidate (MPH) for ADHD at an epilepsy center between 1998 and 2005.

Investigators from Boston Children's Hospital; the Lahey Clinic, Burlington, MA; and Ohio State University, report 3 children presenting between ages 9 and 10 years with proximal lower extremity weakness with areflexia and low-amplitude compound muscle action potentials, and diagnosed with Lambert-Eaton myasthenic syndrome.

Investigators at Cincinnati Children's Hospital, OH, studied the prevalence of hypopituitarism in children with inflicted traumatic brain injury.

Investigators at UCSF, British Columbia, and Toronto studied the pattern and areas of brain injury on MRI at third day of life of children with infantile spasms following neonatal hypoxic-ischemic encephalopathy (H-IE).

Investigators at Children's Hospital of Chongqing Medical University, China, reviewed children diagnosed with acute transverse myelitis (ATM) between 1995 and 2008 and selected 39 patients diagnosed according to the new Johns Hopkins Consortium criteria.

Investigators at Kocaeli University, Pediatric Neurology OP Clinic, Turkey, studied the relationship between fine motor skills and seizure and treatment parameters in 44 children with rolandic epilepsy (RE) and compared to 44 healthy controls.

Investigators at Georgia Regents University, Augusta, GA, and multiple centers (25) in the USA and UK, studied the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD Study) in 195 children of pregnant women with epilepsy who had received AED monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) from 1999 to 2004.

Investigators from Tubingen and Munster, Germany, report the case of a 32-year-old woman who at 32 weeks of pregnancy developed a change in personality, disorientation, ataxia, dysarthria, and hemispasticity.