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Male albino rats were fed isocalorically on diets containing 5%, 20%, and 40% protein (casein) and 10% corn oil by weight at environmental temperatures of 22 °C and 2 °C. Since the 5% protein fed group consumed less than normal amounts of food, consequently the food intake of all groups was moderately restricted. Measurements were made of urinary excretion of nitrogen, potassium, sodium, phosphorus, and creatinine, of blood levels of glucose, urea, amino nitrogen, packed cell volume, and serum total proteins and of total body content of protein, water, and crude fatty acids. Metabolic effects of dietary protein level were readily apparent at both environmental temperatures. Unlike earlier studies with ad libitum and severely restricted feeding, superimposition of cold exposure did not eliminate metabolic differences among groups. As observed in previous studies, reduction of dietary protein level from 20% to 5% had a deleterious effect in cold-exposed rats. In the present study no beneficial effects due to increasing dietary protein level from 20% to 40% were observed.

Male albino rats were fed ad libitum isocaloric diets containing 5%, 20%, and 40% protein and 10% corn oil by weight. Measurements were made of nitrogen retention, urine volume, water intake, body composition, and blood levels of glucose, amino nitrogen, and urea at environmental temperatures of 22 ± 2 °C (7 days) followed by 2 ± 1 °C (8 days). Significant metabolic differences were evident among the three dietary groups at 22 °C but these differences were, in general, reduced under conditions of cold exposure. It is of interest that the rats on the 40% protein diet did not exhibit the typical increases in food consumption and urine volume when exposed to cold and, further, that these animals appeared able to maintain body weight and synthesize body fat during cold exposure. It seems that dietary protein level may play an important role during exposure to cold.

In these studies, male albino rats were exposed to cold (2–3 °C) for a 7-day period. In vivo studies included the daily measurement of body weight gain, food intake, urine volume, body and liver composition, and nitrogen retention. In vitro, the activities of the following liver enzymes were measured: aspartic acid transaminase, alanine transaminase, arginase, glutamic acid dehydrogenase, and phosphate-activated glutaminase. The results of these experiments demonstrate that exposure of rats to cold increases amino acid catabolism, in part at least to meet increased energy requirements, and reduces protein synthesis as a consequence in the period 2–5 days inclusive, despite a marked increase in food intake. Cold exposure was without effect upon protein absorption but, after 24 hours in the cold, the nitrogen which appeared in the urine increased from about 55% (at 22 °C) to about 76% of the amount that had been absorbed. No effect of cold exposure on nitrogen retention was apparent in the first 24 hours of cold exposure. The subsequent decreased nitrogen retention, on a time basis, appears to bear a relationship to changes in liver enzyme activities, particularly to the increased activities of liver transaminases and arginase.

Male, growing rats were injected daily with anterior pituitary growth hormone (3 mg/100 g body weight) and fed ad libitum for 7 days at environmental temperatures of 22 °C and 2–3 °C. Body weight gain, nitrogen retention, and four liver enzyme activities were measured. As observed previously, cold exposure retarded body weight gain and decreased nitrogen retention despite an increased food intake. These effects of cold were not eliminated by administration of growth hormone. The increased activities of liver arginase, alanine-glutamic transminase, and phosphate-activated glutaminase consequent upon cold exposure were not significantly affected by growth hormone although, at 22 °C, growth hormone decreased the activities of liver arginase and alanine-glutamic transaminase. Cold exposure eliminated the lowering effect of growth hormone on liver glutamic acid dehydrogenase activity observed at 22 °C. It is concluded that, under these conditions, growth hormone does not overcome the protein catabolic effects of cold exposure but rather, cold exposure eliminates the protein anabolic effects of the hormone.

Several studies have been made to obtain larger classes of non-associative algebras from classes of algebras with a known structure. Thus, we have right alternative algebras (2)* and non-commutative Jordan algebras (6), (7), (8), and (9). These algebras are defined by a subset of the set of identities of the algebras from which they derive their names. Also, Albert (1), among others has studied Jordan admissible algebras. This paper is concerned with algebras which are related to Lie algebras in that they satisfy some of the identities of a Lie algebra and are Lie admissible. Theorem 2 answers a question raised by Albert in (1).

Let m,n"1,n"2,...,n"m and c be positive integers. Let A = {A"1, A"2, ... A"m} be a system of sequences of integers A"i = (a"i"1 < a"1"2 < ... < a"i"n"i; i=1,...,m, and let D"i = {a"i"j - a"i"k @? 1 =< k < j =< n"i} be the difference set of A"j. Then S = {D"2, D"2,...,D"m} is a perfect system of difference sets if D=D"[email protected]?D"[email protected][email protected]?D"m=c,c+1,...,[email protected]?i=1mn"i2 Such a system is trivial if n"i = 2 for at least one i. Paul Erdos conjectured that, for every positive integer e, except for a finite number of them, there is a non-trivial perfect system of difference sets whose differences are the first e positive integers. These exceptions are discussed and a proof of the conjecture is given.

More than 90 squirrel monkeys with bilateral myringotomies (a small hole in each ear drum) were rapidly decompressed in a hyperbaric chamber according to a special diving profile in which 35% of attempts produced disorders ("hits") confined to the inner ear. Monkeys receiving inner ear hits (as determined by the sudden onset of vigorous head or eye nystagmus during decompression) were tested and killed at times ranging from 1 h to more than 12 mo following the dive. Histologically, in monkeys killed 1 mo or less after the hit, hemorrhage and/or a deep purple-staining precipitated material were frequently found in the otic fluid spaces. In those monkeys killed more than 1 mo after a hit, ectopic new bone growth in the arms of the semicircular canals was a common sequela. New bone growth never appeared in the cochlea. In unaffected ears, and in both ears of control animals, the precipitated material was somewhat less than in ears damaged by decompression; and, furthermore, new bone growth did not occur. Behaviorally, the hit monkeys showed vestibular deficits that were consistent with the structural damage revealed by histology.

Histological examination of the gingivovestibular lesion in the first case with known kidney cancer, confirmed the metastatic nature of the buccal tumor and its origin. The second case raised the problem of the diagnosis of a labial swelling occurring during widespread metastases from breast cancer. The third case was more complex as the palatine lesion was seen initially, and metastatic seeding extremely rapid. This led to the hypothesis only, that bronchial cancer was the primary lesion.

Rapid regression of all symptoms was obtained after moderate chemotherapy in two women aged 69 and 77 years respectively with malignant non-Hodgkin's lymphomas. Cervico-facial locations of these tumors are discussed in relation to definition, etiology, geographic factors, genetic markers, and associated immunologic disorders. Diagnosis requires a series of explorations including, obviously as a last resort, exploratory cervicotomy. Other regions may be involved and must be investigated, but lesions not affecting lymph nodes occur in only approximately 2 p. cent of patients with cervico-facial malignant non-Hodgkin's lymphoma (approximately 10 p. cent of all malignant non-Hodgkin's lymphomas). Other localizations include the hard palate, gums, sinuses, and salivary glands. Burkitt's lymphoma represents, on the contrary, 30 p. cent of malignant non-Hodgkin's lymphoma seen in European children. The different therapeutic modalities available are discussed.

There recently treated cases of primary buccal syphilis are reported. The lesions are discussed, with the aid of photographs, and overall symptomatology described with the aim of providing permanent training of the young. A review of primary, secondary and tertiary syphilis is followed by a summary of diagnostic criteria and therapy.

A case of polymorphic erythema which could have been caused by a gonococcal infection is used as a basis for retracing the evolution of the gonococcus at the present time, describing the conditions necessary for its diagnosis, and discussing the possible interpretation of this case.

Publisher Summary This chapter discusses instability and turbulence in fully developed flows. In the past, the instability and turbulence were treated quite separately and differently. The former was cast into an eigen-value problem in which an unsteady, linear partial differential equation, the well-known Orr-Summerfeld equation, was solved; the point of departure of the latter one is the Reynolds equations, a set of time averaged, nonlinear partial differential equations that are incomplete. The main objective was to study the behavior of these structures in space and time and, in particular, to understand the dynamics of their motion. It was also seen that the results described were deduced using a deterministic point of view: the vortex structures generated by the unstable shear layer interact with each other through an induction mechanism. The random behavior was caused by outside and self-induced disturbances that produce phase fluctuations in the interaction process. Finally, if the description of the flow development is a realistic one, one must conclude that the turbulent transport process is actuated by a long range force field, the induced pressure field and, therefore, cannot be expressed in terms of a local gradient diffusion model.

Three hundred volunteers were divided into two age groups, 14-30 years and 31-60 years. Each participant was immunized intramuscularly with a subunit, whole virus or absorbed whole virus vaccine, containing A/Bangkok/1/79 (H3N2), A/Brazil/11/78 (H1N1) and B/Singapore/222/79 influenza virus. Serum haemagglutination-inhibition (HI) antibody response, protection, and reactogenicity were studied after one and two doses of the vaccines. Primary immunization induced much higher percentages of HI antibody titres greater than or equal to 100 against all three vaccine viruses and much higher geometric mean titres (GMT) in volunteers with pre-immunization titres greater than or equal to 18 as compared to those with pre-immunization titres less than 18. Secondary immunization did not result in an increase of GMTs or antibody titres greater than or equal to 100 in volunteers with pre-immunization titres less than 18. On the whole, the response to the subunit vaccine was similar to that to the other two vaccines. To influenza B/Singapore/222/79 virus the response was lowest after administration of the whole virus vaccine in the age group 31-60 years. Over 50% of the HI titres greater than or equal to 100 found after immunization in the different vaccine and age groups were still present after one year. Serologically established infections during the winter months following immunization amounted to 15% in the subunit vaccine group, 6% in the whole virus vaccine group, and 10% in the adsorbed whole virus vaccine group. Local and systemic reactions to all three vaccines were mild in nature. Local reactions after primary immunization were much less frequent following administration of the subunit vaccine as compared to the other two vaccines, especially in the younger age group. In comparison to primary immunization, after booster immunization the incidence of local reactions was higher for the subunit vaccine and lower for the adsorbed whole virus vaccine. In the age group 14-30 years the incidence of local reactions after primary as well as booster immunization was much greater in females than in males, especially when the adsorbed whole virus vaccine was used.

The authors describe several cases of zoster, including some patients who developed skin or bone necrosis, and discuss the principal therapeutics proposed at the present time.

Buccal lesions observed in the clinical setting of human immunodeficiency virus (HIV) infection constitute a diverse group of pathological entities. Several are related to the opportunistic infections observed in association with HIV infection. "Hairy leukoplakia" is a recently described benign lesion that is presumably related to infection by Epstein-Barr virus (E.B.V.). Kaposi's sarcoma is seen somewhat frequently in the oral cavity, especially involving the palate of HIV infected patients. We have observed this lesion 19 times in this location. The diagnosis is usually relatively straight-forward. Both vascular inflammatory and more typical sarcomatous morphology sub-types are present. The salivary glands may show an important lymphoplasmocytic infiltration which is unusual in that associated epithelial changes are not observed. The salivary glands seem to be a seat of the lymphocytic infiltration seen in other organs during the course of HIV infection. As for the changes encountered in the lymph nodes in HIV infection, they represent different stages in the evolution of a dynamic process, which progresses from hyperplasia to atrophy of the lymph nodes.

Using the technique of central diamonds' suggested by A. Kotzig, we resolve the problem of determining all perfect (6, 5, 1)-systems and a special class of perfect systems for the case (8, 5, 1).

The authors report a case of ulcerovegetating lesions of the buccal mucosa in a patient with confirmed cutaneous and biological secondary syphilis, and discuss the diagnostic features of ulcerovegetating mucous syphilids which correspond to the lesion originally described by Milian, and to the diagram illustrating the work by Grinspan quoted in the references.

Three cases treated by medical means are reported, and reports in the published literature briefly reviewed. --Anatomically the temporal styloid process is related to four main structures : the carotid artery and vein, and the facial and glossopharyngeal nerves. --Hypotheses as to the pathogenesis of these lesions are based on clinical findings. The anomalies may be discovered : 1) On radiological examination. 2) Present as pain in the tonsillar region radiating to the neck. 3) Fronto-orbital or temporo-occipital headaches. 4) Sudden repetitive bouts of syncope. --Therapy includes psychotherapy, local infiltration of an anesthetic, or removal of a fragment of the calcified styloid process by a cervical or pharyngeal approach.

The membrane effects of 4 sea anemone and 6 scorpion toxins have been studied under current clamp and voltage clamp conditions. Micromolar concentrations of the purified toxins were applied externally on single giant axons of the american cockroach. Periplaneta americana in a double oil-gap arrangement and the effects on the resting potential, action potential and underlying currents analysed. The 4 sea anemone toxins (Condylactis toxin, Anemonia toxin 2, Anthopleurin toxin A and Parasicyonis toxin) were found to considerably prolong the action potential. This effect is frequency dependent and long plateau spikes (100-500 ms in duration) are consistently seen for frequencies lower than 0.2 Hz. This effect is due to a considerable delay in the turning-off of the sodium current during square membrane depolarizations associated, for large concentrations, with a decrease in the potassium conductance. Toxin effects on the sodium current are not prevented by pretreatment with STX. From the 4 purified toxins extracted from the venom of the scorpion, Androctonus australis Hector, 3 (Mammal toxins 1 and 2 and crustacean toxin) were found to have sea anemone toxin like effects and to induce long duration plateau action potentials. As for sea anemone toxins, this effect is due to a lengthening of the falling phase of the sodium current associated with a small decrease in the potassium conductance. The 4th toxin (insect toxin or ITAaH) depolarizes the membrane and induces repetitive firing of short action potentials.(ABSTRACT TRUNCATED AT 250 WORDS)

Gardner's syndrome is an association of rectopolyposis, to which the prognosis is related, with bony lesions : osteomas, essentially craniofacial, and osteocementosis : dental : multiple inclusions, supernumerary teeth; and cutaneous manifestations : lipomas, adenomas, fibromas ; and sometimes desmoid tumours, either cutaneous at the site of an abdominal scar, sometimes mesenteric. This complex histodysplasia, subject to the possibility of complications where it occurs (in particular craniofacial osteomas) requires digestive surveillance and further treatment when necessary : colectomy with colo-rectal anastomosis associated with coagulation diathermy of rectal polyps. When the latter is impossible, abdominoperineal excision of the rectum is followed by permanent ileostomy.

Postmortem human tissue from recently deceased divers was processed histologically to assess any inner and middle ear damage that could have resulted from the effects of pressure during diving. The following new findings are particularly noteworthy. In one diver, ascent while breath holding resulted in the rupture of the ear drum and blood in the middle ear, in addition to pulmonary barotrauma. In a second diver, following inner ear decompression sickness, new bone growth, similar to that described earlier in experimental studies with the squirrel monkey, was observed in the arms of one of the semicircular canals. These observations are further confirmation that otologic disorders can be a serious threat to divers.

The mouse was selected to provide an experimental model for Sjögren's disease. A comparative study was made between the normal mouse (C 57 Bl 6) and the spontaneously auto-immune mouse (NZB) from an immunological and scintigraphic standpoint. The first immunological results involve study of the effects of sub-mandibulectomy on the thymus of the C 57 Bl 6 mouse. The are of little significance. First scintigraphic results show marked differences from the point of view of the uptake and excretion of Technetium 99 between normal old mice (17 months) (C 57 Bl 6) and those with spontaneous auto-immune behavior. Dynamic graphs of the uptake and excretion of Technetium 99 in the latter are closely similar to those found in mice after sub-mandibulectomy.

Hemolymphangioma of the tongue is a benign vascular tumor. Episodes of activity lead progressively to the development of macroglossia which causes secondary complications. The clinical diagnosis of the tumor is confirmed by arteriography with superselective catheterisation. Arteriography assesses blood flow in the malformation, serving as a basis for classification and permitting embolisation of the tumor, the first stage of treatment.

A personal series of eight patients with Heck's disease is reviewed and the historical background, clinical aspects and pathologic and viral substrates of this affection discussed. No attempt is made to provide an exhaustive bibliography because of the very numerous publications on the subject. (Four clinical photography documents, 29 references concerning clinical and histologic data and a short series of 7 articles on virologic aspects).

Hyalinosis cutis et mucosae is a rare genetic disorder, primarily involving skin and mucous membranes, that has been described under various titles as lipoidosis lipoproteinosis and Urbach-Wiethe disease. A 17-year-old girl presented cutaneous macular lesions, skin scars, thickened lips and enlarged firm tongue; hoarseness was known since birth. The labial biopsy specimen was investigated by light and electron microscopy. Histologically there are deposits of amorphous, extra-cellular eosinophilic hyaline material in the upper thickened connective tissue. In the lower part changes are focal with hyaline mantle around the vessels. Histochemical studies have revealed that the deposits were PAS-positive and amylase-resistant, indicating the presence of neutral mucopolysaccharides. Lipid stains were positive, especially in vessel walls. Ultrastructurally hyaline substance is composed of 1 to 2 nm protofilaments, larger ones (5 to 10 nm wide) and amorphous material. Fibroblasts contain in their dilated cisternae amorphous material. A frequent feature is marked multilamination of the capillary basal lamina which is interpenetrated by hyaline substance. Pathogenesis is still unknown but recently it is suggested hyalinosis cutis et mucosae could be a systemic disease of basal lamina.

LAV/HTL VIII virus found in 1983, renamed HIV in 1986, is doing with many clinical manifestations among which AIDS is only ultimate one, and the more serious aspect of infection by the virus. At each stage of the disease, oro-facial manifestations can be encountered, often the first one. That emphasises for oral medicine the need of perfect knowledge of these clinical aspects concerning 111 patients, we will describe these clinical aspects and hygienical and preventive precautions we choose.

The third case of Cowden's disease to be discovered in France is reported. The authors emphasize the means for the diagnosis of multiple hamartomata, the typical symptoms and signs in the case reported, and that the family history included a daughter aged 8 years with macrocephaly, and slight mental retardation, who had already been operated upon twice for tonsillectomy.

Concerning five observations of cervico-facial actinomycosis in two hospital wards, the authors recall that this pathology, although rare, still exists. It appears as a chronic cellulitis, usually occurring among subjects lacking in dental hygiene. The authors insist on the necessity of asking for a bacteriological test by taking a sample of pus with a pipette to look for the responsible actinomyces. The cure consists in the extracting of the teeth concerned, the removal of the necrosed tissues, a drainage, and an antibiotic treatment based on high doses of Penicilline for about three months.

After a brief account of the history and pathogeny, two cases are described of sub-angiomal bone hypo and hypertrophy. Other cases in the literature are recalled. Finally, a differential diagnosis is given.

Morphometric measurements were made from serial sections of the vestibular system in four classes of vertebrates: Reptilia, Aves, Amphibia, and Pisces. Representative species of reptile studied were the lizard (Gekko gecko), the common garter snake (Thamnophis sp.), and the common turtle (Chelonia sp.). The budgie (Melopsittacus undulatas), the common pigeon (Columba domestica), the yellow-bellied sapsucker (Sphyrapicus varius), and the horned owl (Bubo virginianus) were chosen as representative of the bird. For the amphibian, the leopard frog (Rana pipiens), and the mud puppy (Necturus maculatus) were chosen for study. As representative of the fish, the goldfish (Carassius auratus), the tilapia (Tilapia mossambica), the guppy (Lebistes sp.), and the sea horse (Hippocampus sp.) were used in these measurements. The morphometric data obtained were then used in estimates of the time constants in the Steinhausen equation which describes the biophysics of fluid flow in the semicircular canals. In general, the time constants (theta/II in the Steinhausen equation) of these representatives of Reptilia, Aves, and Amphibia were of magnitude similar to those reported in mammals, despite the dissimilarities in the diameters of the ducts, the duct radii of curvature, the dimensions of the cristae ampullares and the utricle, and volumes of endolymph within the vestibular system. However, the short-time constants in Pisces were larger (therefore providing a slower response) than those in other vertebrates, and were similar to that of the turtle and the mud puppy.