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51. Cardiac MRI for Evaluation of Radiation-Induced Cardiotoxicity in Breast Cancer Patients: A Phase II Clinical Trial

Author

Speers, C., primary, Murthy, V.L., additional, Walker, E.M., additional, Morris, E., additional, Glide-Hurst, C., additional, Schipper, M., additional, Marsh, R., additional, Weinberg, R., additional, Gits, H.C., additional, Moran, J.M., additional, Hayman, J.A., additional, Feng, M., additional, Griffith, K., additional, Balter, J., additional, Jagsi, R., additional, and Pierce, L.J., additional

Published
2019
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52. Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features

Author

Jagsi, R., primary, Griffith, K., additional, Harris, E.E., additional, Wright, J.L., additional, Recht, A., additional, Taghian, A.G., additional, Lee, L., additional, Moran, M.S., additional, Thomas, T.O., additional, Johnstone, C., additional, Rahimi, A.S., additional, Freedman, G.M., additional, Muzaffar, M., additional, Haffty, B.G., additional, Horst, K.C., additional, Powell, S.N., additional, Sharp, J., additional, Sabel, M.S., additional, Schott, A.F., additional, and El-Tamer, M., additional

Published
2019
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53. Use of Chemotherapy in Patients Receiving Hypofractionated Whole-Breast Irradiation: An Analysis within a State-Wide Quality Consortium

Author

Dilworth, J.T., primary, Griffith, K., additional, Vicini, F.A., additional, Jagsi, R., additional, Dominello, M.M., additional, Hayman, J.A., additional, Moran, J.M., additional, Radawski, J.D., additional, Gustafson, G.S., additional, Boike, T.P., additional, Walker, E.M., additional, and Pierce, L.J., additional

Published
2019
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54. Factors Associated with Patient-Reported and Physician-Assessed Acute Toxicity after Hypofractionated Breast Radiotherapy, a Report from a Large Multi-Center Cohort Study

Author

Dominello, M.M., primary, Jagsi, R., additional, Griffith, K., additional, Vicini, F.A., additional, Dilworth, J.T., additional, Moran, J.M., additional, Burmeister, J.W., additional, Hayman, J.A., additional, Paximadis, P.A., additional, Boike, T.P., additional, Gustafson, G.S., additional, Radawski, J.D., additional, Walker, E.M., additional, and Pierce, L.J., additional

Published
2019
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55. Lessons Learned from Hurricane Maria in Puerto Rico: Practical Measures to Mitigate the Impact of a Catastrophic Natural Disaster on Radiation Oncology Patients

Author

Gay, H.A., primary, Santiago, R., additional, Gil, B., additional, Remedios, C., additional, Montes-Garcia, P.J., additional, Araujo, J. Lopez, additional, Chevere, C.M., additional, Imbert, W.S., additional, White, J.R., additional, Arthur, D.W., additional, Horton, J.K., additional, Jagsi, R., additional, Rabinovitch, R.A., additional, Beriwal, S., additional, Viswanathan, A.N., additional, Erickson, B.A., additional, Rengan, R., additional, Palma, D.A., additional, Loo, B.W., additional, Kavanaugh, J., additional, Bradley, J.D., additional, Yom, S.S., additional, Harari, P.M., additional, and Burnett, O.L.L., additional

Published
2019
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56. Are We Missing Acute Toxicities Associated with Hypofractionated Breast Irradiation? A Report from a Large Multi-Center Cohort Study

Author

Beydoun, H., primary, Jagsi, R., additional, Griffith, K., additional, Burmeister, J.W., additional, Moran, J.M., additional, Vicini, F.A., additional, Dilworth, J.T., additional, Hayman, J.A., additional, Paximadis, P., additional, Boike, T.P., additional, Gustafson, G.S., additional, Radawski, J.D., additional, Walker, E.M., additional, Pierce, L.J., additional, and Dominello, M.M., additional

Published
2019
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58. Abstract P1-12-18: Mechanical properties of the shoulder and pectoralis major in women undergoing breast conserving therapy with axillary dissection and regional nodal radiotherapy versus sentinel node biopsy and radiotherapy to the breast alone

Author

Lipps, DB, primary, Leonardis, JM, additional, Lehmann, S, additional, Dess, RT, additional, McGinnis, G, additional, Strauss, JB, additional, Hayman, JA, additional, Pierce, LJ, additional, and Jagsi, R, additional

Published
2019
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60. 20-year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years

Author

Pan, H, Gray, R, Braybrooke, J, Davies, C, Taylor, C, Mcgale, P, Peto, R, Pritchard, Ki, Bergh, J, Dowsett, M, Hayes, Df, Albain, K, Anderson, S, Arriagada, R, Barlow, W, Bartlett, J, Bergsten‐nordström, E, Bliss, J, Boccardo, F, Bradley, R, Brain, E, Cameron, D, Clarke, M, Coates, A, Coleman, R, Correa, C, Costantino, J, Cuzick, J, Davidson, N, Dodwell, D, Di Leo, A, Ewertz, M, Forbes, J, Gelber, R, Gnant, M, Goldhirsch, A, Goodwin, P, Hill, C, Ingle, J, Jagsi, R, Janni, W, Loibl, S, Mackinnon, E, Martin, M, Mukai, H, Norton, L, Ohashi, Y, Paik, S, Perez, E, Piccart, M, Pierce, L, Poortmans, P, Raina, V, Ravdin, P, Regan, M, Robertson, J, Rutgers, E, Slamon, D, Sparano, J, Swain, S, Tutt, A, Viale, G, Von Minckwitz, G, Wang, X, Whelan, T, Wilcken, N, Winer, E, Wolmark, N, Wood, W, Zambetti, M, Alberro, Ja, Ballester, B, Deulofeu, P, Fábregas, R, Fraile, M, Gubern, Jm, Janer, J, Moral, A, De Pablo Jl, Peñalva, G, Puig, P, Ramos, M, Rojo, R, Santesteban, P, Serra, C, Solà, M, Solarnau, L, Solsona, J, Veloso, E, Vidal, S, Abe, O, Abe, R, Enomoto, K, Kikuchi, K, Koyama, H, Masuda, H, Nomura, Y, Sakai, K, Sugimachi, K, Toi, M, Tominaga, T, Uchino, J, Yoshida, M, Haybittle, Jl, Leonard, Cf, Calais, G, Garaud, P, Collett, V, Delmestri, A, Sayer, J, Harvey, Vj, Holdaway, Im, Kay, Rg, Mason, Bh, Forbes, Jf, Balic, M, Bartsch, R, Fesl, C, Fitzal, F, Fohler, H, Greil, R, Jakesz, R, Marth, C, Mlineritsch, B, Pfeiler, G, Singer, Cf, Steger, Gg, Stöger, H, Canney, P, Yosef, Hma, Focan, C, Peek, U, Oates, Gd, Powell, J, Durand, M, Mauriac, L, Dolci, S, Larsimont, D, Nogaret, Jm, Philippson, C, Piccart, Mj, Masood, Mb, Parker, D, Price, Jj, Lindsay, Ma, Mackey, J, Hupperets, Psgj, Bates, T, Blamey, Rw, Chetty, U, Ellis, Io, Mallon, E, Morgan, Dal, Patnick, J, Pinder, S, Lohrisch, C, Nichol, A, Bramwell, Vh, Chen, Be, Gelmon, K, Goss, Pe, Levine, Mn, Parulekar, W, Pater, Jl, Shepherd, Le, Tu, D, Berry, D, Broadwater, G, Cirrincione, C, Muss, H, Weiss, Rb, Abu‐zahra, Ht, Portnoj, Sm, Bowden, S, Brookes, C, Dunn, J, Fernando, I, Lee, M, Poole, C, Rea, D, Spooner, D, Barrett‐lee, Pj, Mansel, Re, Monypenny, Ij, Gordon, Nh, Davis, Hl, Sestak, I, Lehingue, Y, Romestaing, P, Dubois, Jb, Delozier, T, Griffon, B, Mace Lesec’h, J, De La Lande, B, Mouret‐fourme, E, Mustacchi, G, Petruzelka, L, Pribylova, O, Owen, Jr, Harbeck, N, Jänicke, F, Meisner, C, Schmitt, M, Thomssen, C, Meier, P, Shan, Y, Shao, Yf, Zhao, Db, Chen, Zm, Howell, A, Swindell, R, Boddington, C, Burrett, Ja, Cutter, D, Duane, F, Evans, V, Gettins, L, Godwin, J, James, S, Kerr, A, Liu, H, Mannu, G, Mchugh, T, Morris, P, Read, S, Wang, Y, Wang, Z, Albano, J, De Oliveira Cf, Gervásio, H, Gordilho, J, Ejlertsen, B, Jensen, Mb, Johansen, H, Mouridsen, H, Palshof, T, Gelman, Rs, Harris, Jr, Henderson, C, Shapiro, Cl, Christiansen, P, Mouridsen, Ht, Fehm, T, Trampisch, Hj, Dalesio, O, De Vries Ege, Rodenhuis, S, Van Tinteren, H, Comis, Rl, Davidson, Ne, Robert, N, Sledge, G, Solin, Lj, Sparano, Ja, Tormey, Dc, Dixon, Jm, Forrest, P, Jack, W, Kunkler, I, Rossbach, J, Klijn, Jgm, Treurniet‐donker, Ad, Van Putten Wlj, Rotmensz, N, Veronesi, U, Bartelink, H, Bijker, N, Bogaerts, J, Cardoso, F, Cufer, T, Julien, Jp, Van De Velde Cjh, Cunningham, Mp, Brufsky, Am, Coleman, Re, Llombart, Ha, Huovinen, R, Joensuu, H, Costa, A, Bonadonna, G, Gianni, L, Valagussa, P, Goldstein, Lj, Bonneterre, J, Fargeot, P, Fumoleau, P, Kerbrat, P, Luporsi, E, Namer, M, Carrasco, E, Segui, Ma, Eiermann, W, Hilfrich, J, Jonat, W, Kaufmann, M, Kreienberg, R, Schumacher, M, Bastert, G, Rauschecker, H, Sauer, R, Sauerbrei, W, Schauer, A, Blohmer, Ju, Costa, Sd, Eidtmann, H, Gerber, B, Jackisch, C, De Schryver, A, Vakaet, L, Belfiglio, M, Nicolucci, A, Pellegrini, F, Pirozzoli, Mc, Sacco, M, Valentini, M, Mcardle, Cs, Smith, Dc, Stallard, S, Dent, Dm, Gudgeon, Ca, Hacking, A, Murray, E, Panieri, E, Werner, Id, Galligioni, E, Leone, B, Vallejo, Ct, Zwenger, A, Lopez, M, Erazo, A, Medina, Jy, Horiguchi, J, Takei, H, Fentiman, Is, Hayward, Jl, Rubens, Rd, Skilton, D, Scheurlen, H, Sohn, Hc, Untch, M, Dafni, U, Markopoulos, C, Fountzilas, G, Mavroudis, D, Klefstrom, P, Blomqvist, C, Saarto, T, Gallen, M, Tinterri, C, Margreiter, R, De Lafontan, B, Mihura, J, Roché, H, Asselain, B, Salmon, Rj, Vilcoq, Jr, André, F, Delaloge, S, Koscielny, S, Michiels, S, Rubino, C, A'Hern, R, Ellis, P, Kilburn, L, Yarnold, Jr, Benraadt, J, Kooi, M, Van De Velde Ao, Van Dongen Ja, Vermorken, Jb, Castiglione, M, Colleoni, M, Collins, J, Gelber, Rd, Lindtner, J, Price, Kn, Regan, Mm, Rudenstam, Cm, Senn, Hj, Thuerlimann, B, Bliss, Jm, Chilvers, Ced, Coombes, Rc, Hall, E, Marty, M, Buyse, M, Possinger, K, Schmid, P, Wallwiener, D, Bighin, C, Bruzzi, P, Del Mastro, L, Dozin, B, Pastorino, S, Pronzato, P, Sertoli, Mr, Foster, L, George, Wd, Stewart, Hj, Stroner, P, Borovik, R, Hayat, H, Inbar, Mj, Peretz, T, Robinson, E, Camerini, T, Formelli, F, Martelli, G, Di Mauro Mg, Perrone, F, Amadori, D, Martoni, A, Pannuti, F, Camisa, R, Musolino, A, Passalacqua, R, Iwata, H, Shien, T, Ikeda, T, Inokuchi, K, Sawa, K, Sonoo, H, Sadoon, M, Tulusan, Ah, Kohno, N, Miyashita, M, Takao, S, Ahn, Jh, Jung, Kh, Korzeniowski, S, Skolyszewski, J, Ogawa, M, Yamashita, J, Bastiaannet, E, Liefers, Gj, Christiaens, R, Neven, P, Paridaens, R, Van Den Bogaert, W, Braun, S, Martin, P, Romain, S, Janauer, M, Seifert, M, Sevelda, P, Zielinski, Cc, Hakes, T, Hudis, Ca, Wittes, R, Giokas, G, Kondylis, D, Lissaios, B, De La Huerta, R, Sainz, Mg, Ro, J, Camphausen, K, Danforth, D, Lichter, A, Lippman, M, Smart, D, Steinberg, S, D’Amico, C, Lioce, M, Paradiso, A, Ohno, S, Bass, G, Brown, A, Bryant, J, Dignam, J, Fisher, B, Geyer, C, Mamounas, Ep, Redmond, C, Wickerham, L, Aihara, T, Hozumi, Y, Baum, M, Jackson, Im, Palmer, Mk, Ingle, Jn, Suman, Vj, Bengtsson, No, Emdin, S, Jonsson, H, Venturini, M, Lythgoe, Jp, Kissin, M, Erikstein, B, Hannisdal, E, Jacobsen, Ab, Reinertsen, Kv, Varhaug, Je, Gundersen, S, Hauer‐jensen, M, Høst, H, Nissen‐meyer, R, Mitchell, Ak, Robertson, Jfr, Ueo, H, Di Palma, M, Mathé, G, Misset, Jl, Levine, M, Morimoto, K, Takatsuka, Y, Crossley, E, Harris, A, Talbot, D, Taylor, M, Cocconi, G, Di Blasio, B, Ivanov, V, Paltuev, R, Semiglazov, V, Brockschmidt, J, Cooper, Mr, Falkson, Ci, Hadji, P, A’Hern, R, Makris, A, Parton, M, Pennert, K, Powles, Tj, Smith, Ie, Gazet, Jc, Browne, L, Graham, P, Corcoran, N, Clack, G, Van Poznak, C, Deshpande, N, Di Martino, L, Douglas, P, Lindtner, A, Notter, G, Bryant, Ajs, Ewing, Gh, Firth, La, Krushen‐kosloski, Jl, Anderson, H, Killander, F, Malmström, P, Rydén, L, Arnesson, Lg, Carstensen, J, Dufmats, M, Fohlin, H, Nordenskjöld, B, Söderberg, M, Carpenter, Jt, Murray, N, Royle, Gt, Simmonds, Pd, Crowley, J, Gralow, J, Hortobagyi, G, Livingston, R, Martino, S, Osborne, Ck, Ravdin, Pm, Bondesson, T, Celebioglu, F, Dahlberg, K, Fornander, T, Fredriksson, I, Frisell, J, Göransson, E, Iiristo, M, Johansson, U, Lenner, E, Löfgren, L, Nikolaidis, P, Perbeck, L, Rotstein, S, Sandelin, K, Skoog, L, Svane, G, Af Trampe, E, Wadström, C, Maibach, R, Thürlimann, B, Holli, K, Rouhento, K, Safra, T, Brenner, H, Hercbergs, A, Yoshimoto, M, Paterson, Ahg, Fyles, A, Meakin, Jw, Panzarella, T, Bahi, J, Lemonnier, J, Martin, Al, Reid, M, Spittle, M, Bishop, H, Bundred, Nj, Forsyth, S, Pinder, Se, Deutsch, Gp, Kwong, Dlw, Pai, Vr, Senanayake, F, Rubagotti, A, Hackshaw, A, Houghton, J, Ledermann, J, Monson, K, Tobias, Js, Carlomagno, C, De Laurentiis, M, De Placido, S, Williams, L, Bell, R, Hinsley, S, Marshall, Hc, Pierce, Lj, Solomayer, E, Horsman, Jm, Lester, J, Winter, Mc, Buzdar, Au, Hsu, L, Love, Rr, Ahlgren, J, Garmo, H, Holmberg, L, Liljegren, G, Lindman, H, Wärnberg, F, Asmar, L, Jones, Se, Aft, R, Gluz, O, Liedtke, C, Nitz, U, Litton, A, Wallgren, A, Karlsson, P, Linderholm, Bk, Chlebowski, Rt, Caffier, H., Guided Treatment in Optimal Selected Cancer Patients (GUTS), Other departments, CCA - Cancer Treatment and Quality of Life, Radiotherapy, Pan, Hongchao, Gray, Richard, Braybrooke, Jeremy, Davies, Christina, Taylor, Carolyn, Mcgale, Paul, Peto, Richard, Pritchard, Kathleen I, Bergh, Jona, Dowsett, Mitch, Hayes, Daniel F, De Laurentiis, Michelino, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and Interne Geneeskunde

Subjects
0301 basic medicine, Oncology, medicine.medical_treatment, Kaplan-Meier Estimate, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Recurrence, Receptors, Neoplasm Metastasis, AMERICAN SOCIETY, Adjuvant, CLINICAL-PRACTICE GUIDELINE, Absolute risk reduction, Estrogen Antagonists, General Medicine, Estrogen Antagonist, CHEMOTHERAPY, Middle Aged, Prognosis, Neoplasm Metastasi, Local, POSTMENOPAUSAL WOMEN, Receptors, Estrogen, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, Meta-analysis, Lymphatic Metastasis, Female, Human, Estrogen Antagonists/therapeutic use, Adult, Risk, medicine.medical_specialty, Prognosi, medicine.drug_class, DISCONTINUATION, Breast Neoplasms, Article, Drug Administration Schedule, LATE DISTANT RECURRENCE, 03 medical and health sciences, Breast cancer, Breast Neoplasms/drug therapy, Internal medicine, SCORE, medicine, Humans, SURGICAL ADJUVANT BREAST, Aged, Proportional Hazards Models, Chemotherapy, business.industry, Proportional hazards model, Lymphatic Metastasi, TAMOXIFEN THERAPY, ta3122, medicine.disease, Estrogen, RANDOMIZED-TRIALS, Discontinuation, Surgery, Neoplasm Recurrence, 030104 developmental biology, Proportional Hazards Model, Neoplasm Grading, Neoplasm Recurrence, Local, business
Abstract

Background The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)–positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment. Methods In this meta-analysis of the results of 88 trials involving 62,923 women with ER-positive breast cancer who were disease-free after 5 years of scheduled endocrine therapy, we used Kaplan–Meier and Cox regression analyses, stratified according to trial and treatment, to assess the associations of tumor diameter and nodal status (TN), tumor grade, and other factors with patients’ outcomes during the period from 5 to 20 years. Results Breast-cancer recurrences occurred at a steady rate throughout the study period from 5 to 20 years. The risk of distant recurrence was strongly correlated with the original TN status. Among the patients with stage T1 disease, the risk of distant recurrence was 13% with no nodal involvement (T1N0), 20% with one to three nodes involved (T1N1–3), and 34% with four to nine nodes involved (T1N4–9); among those with stage T2 disease, the risks were 19% with T2N0, 26% with T2N1–3, and 41% with T2N4–9. The risk of death from breast cancer was similarly dependent on TN status, but the risk of contralateral breast cancer was not. Given the TN status, the factors of tumor grade (available in 43,590 patients) and Ki-67 status (available in 7692 patients), which are strongly correlated with each other, were of only moderate independent predictive value for distant recurrence, but the status regarding the progesterone receptor (in 54,115 patients) and human epidermal growth factor receptor type 2 (HER2) (in 15,418 patients in trials with no use of trastuzumab) was not predictive. During the study period from 5 to 20 years, the absolute risk of distant recurrence among patients with T1N0 breast cancer was 10% for low-grade disease, 13% for moderate-grade disease, and 17% for high-grade disease; the corresponding risks of any recurrence or a contralateral breast cancer were 17%, 22%, and 26%, respectively. Conclusions After 5 years of adjuvant endocrine therapy, breast-cancer recurrences continued to occur steadily throughout the study period from 5 to 20 years. The risk of distant recurrence was strongly correlated with the original TN status, with risks ranging from 10 to 41%, depending on TN status and tumor grade. (Funded by Cancer Research UK and others.)

Published
2017

61. A cardiac contouring atlas for radiotherapy

Author

Duane, F, Aznar, MC, Cutter, DJ, Darby, SC, Jagsi, R, Lorenzen, EL, McArdle, O, McGale, P, Myerson, S, Rahimi, K, Vivekanandan, S, Warren, S, and Taylor, CW

Abstract

Background and Purpose: The heart is a complex anatomical organ and contouring the cardiac substructures is challenging. This study presents a reproducible method for contouring left ventricular and coronary arterial segments on radiotherapy CT-planning scans. Material and Methods: Segments were defined from cardiology models and agreed by two cardiologists. Reference atlas contours were delineated and written guidelines prepared. Six radiation oncologists tested the atlas. Spatial variation was assessed using the DICE similarity coefficient (DSC) and the directed Hausdorff average distance (𝑑⃗𝐻,𝑎𝑣𝑔). The effect of spatial variation on doses was assessed using six different breast cancer regimens. Results: The atlas enabled contouring of 15 cardiac segments. Inter-observer contour overlap (mean DSC) was 0.60-0.73 for five left ventricular segments and 0.10-0.53 for ten coronary arterial segments. Inter-observer contour separation (mean 𝑑⃗𝐻,𝑎𝑣𝑔 ) was 1.5-2.2 mm for left ventricular segments and 1.3-5.1 mm for coronary artery segments. This spatial variation resulted in Conclusions: This cardiac atlas enables reproducible contouring of segments of the left ventricle and main coronary arteries to facilitate future studies relating cardiac radiation doses to clinical outcomes.

Published
2017

62. NRG Oncology/RTOG 1014: Patient Reported Outcomes (PRO) and Cosmesis From a Phase II Study of Repeat Breast Preserving Surgery and 3D Conformal (3D-CRT) Partial Breast Re-Irradiation (PBrI) for In-Breast Recurrence.

Author

Arthur, D.W., primary, Moughan, J., additional, Kuerer, H.M., additional, Haffty, B.G., additional, Cuttino, L.W., additional, Woodward, W.A., additional, Todor, D.A., additional, Simone, N.L., additional, Anderson, P.R., additional, Strom, E.A., additional, McCormick, B., additional, Cohen, R.J., additional, Sahijdak, W.M., additional, Matunlonis, U., additional, Brown, D.R., additional, Currey, A.D., additional, Fisher, C.M., additional, Jagsi, R., additional, Winter, K., additional, and White, J.R., additional

Published
2018
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64. Increasing use of Hypofractionated Whole Breast Irradiation: An Analysis of Practice Patterns within a State-Wide Quality Consortium

Author

Dilworth, J.T., primary, Griffith, K., additional, Vicini, F.A., additional, Hayman, J.A., additional, Moran, J.M., additional, Radawski, J.D., additional, Jagsi, R., additional, Gustafson, G.S., additional, Boike, T.P., additional, Walker, E.M., additional, Dominello, M.M., additional, and Pierce, L.J., additional

Published
2018
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65. Gene Expression Changes Predict Acute and Late Toxicity to Combined PARP1 Inhibition and Radiation (RT) in High Risk Breast Cancer Patients- Results of the Biomarker Analysis of TBCRC 024

Author

Speers, C., primary, Chandler, B., additional, Olsen, E., additional, Moubadder, L., additional, Thomas, D., additional, Liu, M., additional, Griffith, K., additional, Bellon, J.R., additional, Woodward, W.A., additional, Horton, J.K., additional, Ho, A.Y., additional, Overmoyer, B., additional, Sabel, M.S., additional, Schott, A.F., additional, Feng, F.Y., additional, Pierce, L.J., additional, and Jagsi, R., additional

Published
2018
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66. Gender, Professional Experiences, and Personal Characteristics of Academic Radiation Oncology Chairs

Author

Beeler, W.H., primary, Griffith, K., additional, Jones, R.D., additional, Chapman, C.H., additional, Holliday, E., additional, Lalani, N., additional, Wilson, E., additional, Bonner, J.A., additional, Formenti, S.C., additional, Hahn, S.M., additional, Kalnicki, S., additional, Liu, F.F., additional, Movsas, B., additional, Thomas, C.R., additional, and Jagsi, R., additional

Published
2018
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69. Abstract OT1-02-04: SWOG S1418/NRG -BR006: A randomized, phase III trial to evaluate the efficacy and safety of MK-3475 as adjuvant therapy for triple receptor-negative breast cancer with > 1 cm residual invasive cancer or positive lymph nodes (>pN1mic) after neoadjuvant chemotherapy

Author

Pusztai, L, primary, Barlow, WE, additional, Ganz, PA, additional, Henry, NL, additional, White, J, additional, Jagsi, R, additional, Mammen, JMV, additional, Lew, D, additional, Mejia, J, additional, Karantza, V, additional, Aktan, G, additional, Sharon, E, additional, Korde, L, additional, Hortobagyi, GN, additional, and Mamounas, E, additional

Published
2018
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71. Abstract P2-11-01: Effects of radiotherapy on breast cancer outcomes among stage I, low-Recurrence risk, hormone-Sensitive breast cancer: Pooled analysis of individual data from phase III trials

Author

Jayasekera, JC, primary, Schechter, C, additional, Jagsi, R, additional, White, J, additional, Chapman, J-AW, additional, Whelan, T, additional, Sparano, JA, additional, Anderson, SJ, additional, Fyles, A, additional, Sauerbrei, W, additional, Zellars, RC, additional, Li, Y, additional, Song, J, additional, Julian, T, additional, Berry, D, additional, Feuer, EJ, additional, Luta, G, additional, and Mandelblatt, JS, additional

Published
2018
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76. A global call for action to include gender in research impact assessment

Author

Ovseiko, PV, Greenhalgh, T, Adam, P, Grant, J, Hinrichs-Krapels, S, Graham, KE, Valentine, PA, Sued, O, Boukhris, OF, Al Olaqi, NM, Al Rahbi, IS, Dowd, A-M, Bice, S, Heiden, TL, Fischer, MD, Dopson, S, Norton, R, Pollitt, A, Wooding, S, Balling, GV, Jakobsen, U, Kuhlmann, E, Klinge, I, Pololi, LH, Jagsi, R, Smith, HL, Etzkowitz, H, Nielsen, MW, Carrion, C, Solans-Domesnech, M, Vizcaino, E, Naing, L, Cheok, QHN, Eckelmann, B, Simuyemba, MC, Msiska, T, Declich, G, Edmunds, LD, Kiparoglou, V, Buchan, AMJ, Williamson, C, Lord, GM, Channon, KM, Surender, R, Buchan, AM, Ovseiko, PV, Greenhalgh, T, Adam, P, Grant, J, Hinrichs-Krapels, S, Graham, KE, Valentine, PA, Sued, O, Boukhris, OF, Al Olaqi, NM, Al Rahbi, IS, Dowd, A-M, Bice, S, Heiden, TL, Fischer, MD, Dopson, S, Norton, R, Pollitt, A, Wooding, S, Balling, GV, Jakobsen, U, Kuhlmann, E, Klinge, I, Pololi, LH, Jagsi, R, Smith, HL, Etzkowitz, H, Nielsen, MW, Carrion, C, Solans-Domesnech, M, Vizcaino, E, Naing, L, Cheok, QHN, Eckelmann, B, Simuyemba, MC, Msiska, T, Declich, G, Edmunds, LD, Kiparoglou, V, Buchan, AMJ, Williamson, C, Lord, GM, Channon, KM, Surender, R, and Buchan, AM

Abstract

Global investment in biomedical research has grown significantly over the last decades, reaching approximately a quarter of a trillion US dollars in 2010. However, not all of this investment is distributed evenly by gender. It follows, arguably, that scarce research resources may not be optimally invested (by either not supporting the best science or by failing to investigate topics that benefit women and men equitably). Women across the world tend to be significantly underrepresented in research both as researchers and research participants, receive less research funding, and appear less frequently than men as authors on research publications. There is also some evidence that women are relatively disadvantaged as the beneficiaries of research, in terms of its health, societal and economic impacts. Historical gender biases may have created a path dependency that means that the research system and the impacts of research are biased towards male researchers and male beneficiaries, making it inherently difficult (though not impossible) to eliminate gender bias. In this commentary, we - a group of scholars and practitioners from Africa, America, Asia and Europe - argue that gender-sensitive research impact assessment could become a force for good in moving science policy and practice towards gender equity. Research impact assessment is the multidisciplinary field of scientific inquiry that examines the research process to maximise scientific, societal and economic returns on investment in research. It encompasses many theoretical and methodological approaches that can be used to investigate gender bias and recommend actions for change to maximise research impact. We offer a set of recommendations to research funders, research institutions and research evaluators who conduct impact assessment on how to include and strengthen analysis of gender equity in research impact assessment and issue a global call for action.

Published
2016

79. NRG Oncology/RTOG 1014: 3 Year Efficacy Report From a Phase II Study of Repeat Breast Preserving Surgery and 3D Conformal Partial Breast Re-Irradiation (PBrI) for In-Breast Recurrence

Author

Arthur, D.W., primary, Moughan, J., additional, Kuerer, H.M., additional, Haffty, B.G., additional, Cuttino, L.W., additional, Todor, D.A., additional, Simone, N.L., additional, Hayes, S.B., additional, Woodward, W.A., additional, McCormick, B., additional, Cohen, R.J., additional, Sahijdak, W.M., additional, Canaday, D.J., additional, Brown, D.R., additional, Currey, A.D., additional, Fisher, C.M., additional, Jagsi, R., additional, and White, J.R., additional

Published
2016
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80. Comparative Effectiveness Analysis of 3DCRT versus Intensity Modulated Radiation Therapy in a Prospective Multicenter Cohort of Breast Cancer Patients

Author

Jagsi, R., primary, Griffith, K.A., additional, Moran, J.M., additional, Matuszak, M.M., additional, Feng, M., additional, Marsh, R., additional, Boike, T.P., additional, Grills, I.S., additional, Gustafson, G.S., additional, Heimburger, D.K., additional, Nurushev, T.S., additional, Radawski, J.D., additional, Walker, E.M., additional, Hayman, J.A., additional, and Pierce, L.J., additional

Published
2016
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81. The 21-Gene Recurrence Score and Locoregional Recurrence Rates in Patients With Node-Positive Breast Cancer Treated on SWOG S8814

Author

Woodward, W.A., primary, Barlow, W.E., additional, Jagsi, R., additional, Buchholz, T.A., additional, Shak, S., additional, Baehner, F., additional, Yoshizawa, C.N., additional, Whelan, T.J., additional, Davidson, N.E., additional, Ingle, J.N., additional, King, T.A., additional, Ravdin, P.M., additional, Osborne, C.K., additional, Tripathy, D., additional, Livingston, R.B., additional, Gralow, J.R., additional, Hortobagyi, G.N., additional, Hayes, D.F., additional, and Albain, K.S., additional

Published
2016
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82. Time Trends and Predictors of Heart Dose From Breast Radiation Therapy in a Large Consortium of Community and Academic Practices

Author

Feng, M., primary, Moran, J.M., additional, Benedetti, L., additional, Boike, T.P., additional, Dryden, D., additional, Fraser, C., additional, Griffith, K.A., additional, Gustafson, G.S., additional, Haywood, J., additional, Jagsi, R., additional, Matuszak, M.M., additional, Nurushev, T.S., additional, Radawski, J.D., additional, Speers, C., additional, Walker, E.M., additional, Hayman, J.A., additional, and Pierce, L.J., additional

Published
2016
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90. Impact of Cardiac Sparing Techniques on Cardiac Doses for Left Breast Cancer Patients: A Multicenter Analysis

Author

Moran, J.M., primary, Feng, M., additional, Marsh, R., additional, Griffith, K.A., additional, Benedetti, L., additional, Grills, I.S., additional, Walker, E.M., additional, Fraser, C., additional, Raymond, S., additional, Blauser, J.P., additional, Gielda, B.T., additional, Vicini, F.A., additional, Wilson, M., additional, Dryden, D.A., additional, Parent, K., additional, Ewald, A., additional, Matuszak, M.M., additional, Jagsi, R., additional, Grubb, M., additional, and Pierce, L.J., additional

Published
2015
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91. Radiation Use and Field Design in Women With Node Positive Breast Cancer Treated With Preoperative Systemic Therapy and Breast Surgery Including Axillary Dissection on a Prospective Clinical Trial ACOSOG Z1071 [Alliance]

Author

Haffty, B.G., primary, McCall, L.M., additional, Ballman, K.V., additional, McLaughlin, S., additional, Jagsi, R., additional, Ollila, D.W., additional, Hunt, K.K., additional, Buchholz, T.A., additional, and Boughey, J.C., additional

Published
2015
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92. NRG Oncology/RTOG 1014: 1-Year Toxicity Report From a Phase II Study of Repeat Breast Preserving Surgery and 3D Conformal Partial-Breast Reirradiation (PBrI) for In-Breast Recurrence

Author

Arthur, D.W., primary, Winter, K., additional, Kuerer, H.M., additional, Haffty, B.G., additional, Cuttino, L.W., additional, Todor, D.A., additional, Simone, N.L., additional, Hayes, S.B., additional, Woodward, W.A., additional, McCormick, B., additional, Cohen, R.J., additional, Sahijdak, W.M., additional, Canaday, D.J., additional, Brown, D.R., additional, Currey, A.D., additional, Fisher, C.M., additional, Jagsi, R., additional, and White, J.R., additional

Published
2015
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