Search

Your search keyword '"Jarius Sven"' showing total 797 results
Start Over Author "Jarius Sven"
797 results on '"Jarius Sven"'

52. Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study)

Author

Hümmert, Martin W, primary, Stern, Carlotta, additional, Paul, Friedemann, additional, Duchow, Ankelien, additional, Bellmann-Strobl, Judith, additional, Ayzenberg, Ilya, additional, Schwake, Carolin, additional, Kleiter, Ingo, additional, Hellwig, Kerstin, additional, Jarius, Sven, additional, Wildemann, Brigitte, additional, Senel, Makbule, additional, Berthele, Achim, additional, Giglhuber, Katrin, additional, Luessi, Felix, additional, Grothe, Matthias, additional, Klotz, Luisa, additional, Schülke, Rasmus, additional, Gingele, Stefan, additional, Faiss, Jürgen H, additional, Walter, Annette, additional, Warnke, Clemens, additional, Then Bergh, Florian, additional, Aktas, Orhan, additional, Ringelstein, Marius, additional, Stellmann, Jan-Patrick, additional, Häußler, Vivien, additional, Havla, Joachim, additional, Pellkofer, Hannah, additional, Kümpfel, Tania, additional, Kopp, Bruno, additional, and Trebst, Corinna, additional

Published
2023
Full Text
View/download PDF

53. Humoral COVID-19 vaccine response in patients with NMOSD/MOGAD during anti-IL-6 receptor therapy compared to other immunotherapies

Author

Schwake, Carolin, primary, Pakeerathan, Thivya, additional, Kleiter, Ingo, additional, Ringelstein, Marius, additional, Aktas, Orhan, additional, Korporal-Kuhnke, Mirjam, additional, Wildemann, Brigitte, additional, Jarius, Sven, additional, Bayas, Antonios, additional, Pul, Refik, additional, Ceylan, Ulas, additional, Faissner, Simon, additional, Hellwig, Kerstin, additional, Ayroza Galvao Ribeiro Gomes, Ana Beatriz, additional, Lipps, Philipp, additional, Pröbstel, Anne-Katrin, additional, Kümpfel, Tania, additional, Oswald, Eva, additional, Then Bergh, Florian, additional, Gödel, Clemens, additional, Hümmert, Martin W, additional, Trebst, Corinna, additional, Gold, Ralf, additional, and Ayzenberg, Ilya, additional

Published
2023
Full Text
View/download PDF

54. Effects of the COVID-19 Pandemic on Patients With NMO Spectrum Disorders and MOG-Antibody–Associated Diseases

Author

Hümmert, Martin W., primary, Bütow, Franziska, additional, Tkachenko, Daria, additional, Ayzenberg, Ilya, additional, Pakeerathan, Thivya, additional, Hellwig, Kerstin, additional, Klotz, Luisa, additional, Häußler, Vivien, additional, Stellmann, Jan-Patrick, additional, Warnke, Clemens, additional, Goereci, Yasemin, additional, Etgen, Thorleif, additional, Luessi, Felix, additional, Bronzlik, Paul, additional, Gingele, Stefan, additional, Lauenstein, Ann-Sophie, additional, Kleiter, Ingo, additional, Rommer, Paulus S., additional, Paul, Friedemann, additional, Bellmann-Strobl, Judith, additional, Duchow, Ankelien, additional, Then Bergh, Florian, additional, Pul, Refik, additional, Walter, Annette, additional, Pellkofer, Hannah, additional, Kümpfel, Tania, additional, Pompsch, Mosche, additional, Kraemer, Markus, additional, Albrecht, Philipp, additional, Aktas, Orhan, additional, Ringelstein, Marius, additional, Senel, Makbule, additional, Giglhuber, Katrin, additional, Berthele, Achim, additional, Jarius, Sven, additional, Wildemann, Brigitte, additional, and Trebst, Corinna, additional

Published
2023
Full Text
View/download PDF

56. sj-docx-1-msj-10.1177_13524585231151212 – Supplemental material for Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study)

Author

Hümmert, Martin W, Stern, Carlotta, Paul, Friedemann, Duchow, Ankelien, Bellmann-Strobl, Judith, Ayzenberg, Ilya, Schwake, Carolin, Kleiter, Ingo, Hellwig, Kerstin, Jarius, Sven, Wildemann, Brigitte, Senel, Makbule, Berthele, Achim, Giglhuber, Katrin, Luessi, Felix, Grothe, Matthias, Klotz, Luisa, Schülke, Rasmus, Gingele, Stefan, Faiss, Jürgen H, Walter, Annette, Warnke, Clemens, Then Bergh, Florian, Aktas, Orhan, Ringelstein, Marius, Stellmann, Jan-Patrick, Häußler, Vivien, Havla, Joachim, Pellkofer, Hannah, Kümpfel, Tania, Kopp, Bruno, and Trebst, Corinna

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-msj-10.1177_13524585231151212 for Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study) by Martin W Hümmert, Carlotta Stern, Friedemann Paul, Ankelien Duchow, Judith Bellmann-Strobl, Ilya Ayzenberg, Carolin Schwake, Ingo Kleiter, Kerstin Hellwig, Sven Jarius, Brigitte Wildemann, Makbule Senel, Achim Berthele, Katrin Giglhuber, Felix Luessi, Matthias Grothe, Luisa Klotz, Rasmus Schülke, Stefan Gingele, Jürgen H Faiss, Annette Walter, Clemens Warnke, Florian Then Bergh, Orhan Aktas, Marius Ringelstein, Jan-Patrick Stellmann, Vivien Häußler, Joachim Havla, Hannah Pellkofer, Tania Kümpfel, Bruno Kopp and Corinna Trebst in Multiple Sclerosis Journal

Published
2023
Full Text
View/download PDF

57. Prognostic relevance of quantitative and longitudinal MOG antibody testing in patients with MOGAD: a multicentre retrospective study

Author

Gastaldi, Matteo, primary, Foiadelli, Thomas, additional, Greco, Giacomo, additional, Scaranzin, Silvia, additional, Rigoni, Eleonora, additional, Masciocchi, Stefano, additional, Ferrari, Sergio, additional, Mancinelli, Chiara, additional, Brambilla, Laura, additional, Mancardi, Margherita, additional, Giacomini, Thea, additional, Ferraro, Diana, additional, Della Corte, Marida, additional, Gallo, Antonio, additional, Di Filippo, Massimiliano, additional, Benedetti, Luana, additional, Novi, Giovanni, additional, Versino, Maurizio, additional, Banfi, Paola, additional, Iorio, Raffaele, additional, Moiola, Lucia, additional, Turco, Emanuela, additional, Sartori, Stefano, additional, Nosadini, Margherita, additional, Ruggieri, Martino, additional, Savasta, Salvatore, additional, Colombo, Elena, additional, Ballante, Elena, additional, Jarius, Sven, additional, Mariotto, Sara, additional, and Franciotta, Diego, additional

Published
2022
Full Text
View/download PDF

62. Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder: a multicenter retrospective study

Author

Ayzenberg, Ilya, Schöllhammer, Joanna, Hoepner, Robert, Hellwig, Kerstin, Ringelstein, Marius, Aktas, Orhan, Kümpfel, Tania, Krumbholz, Markus, Trebst, Corinna, Paul, Friedemann, Pache, Florence, Obermann, Mark, Zeltner, Lena, Schwab, Matthias, Berthele, Achim, Jarius, Sven, Kleiter, Ingo, and Neuromyelitis Optica Study Group (NEMOS)

Published
2016
Full Text
View/download PDF

65. The Brain Reacting to COVID-19: Analysis of the Cerebrospinal Fluid and Serum Proteome,Transcriptome and Inflammatory Proteins

Author

Reinhold, Dirk, primary, Farztdinov, Vadim, additional, Yan, Yan, additional, Meisel, Christian, additional, Sadlowski, Henrik, additional, Kühn, Joachim, additional, Perschel, Frank H., additional, Endres, Mathias, additional, Düzel, Emrah, additional, Vielhaber, Stefan, additional, Guttek, Karina, additional, Goihl, Alexander, additional, Venø, Morten, additional, Teegen, Bianca, additional, Stöcker, Winfried, additional, Stubbemann, Paula, additional, Kurth, Florian, additional, Sander, Leif E., additional, Ralser, Markus, additional, Otto, Carolin, additional, Streit, Simon, additional, Jarius, Sven, additional, Ruprecht, Klemens, additional, Radbruch, Helena, additional, Kjems, Jørgen, additional, Mülleder, Michael, additional, Heppner, Frank, additional, and Körtvelyessy, Peter, additional

Published
2022
Full Text
View/download PDF

66. Costs and Health-Related Quality of Life in Patients With NMO Spectrum Disorders and MOG-Antibody–Associated Disease

Author

Hümmert, Martin, Schöppe, Louisa, Bellmann-Strobl, Judith, Siebert, Nadja, Paul, Friedemann, Duchow, Ankelien, Pellkofer, Hannah, Kümpfel, Tania, Havla, Joachim, Jarius, Sven, Wildemann, Brigitte, Berthele, Achim, Bergh, Florian, Pawlitzki, Marc, Klotz, Luisa, Kleiter, Ingo, Stangel, Martin, Gingele, Stefan, Weber, Martin, Faiss, Juergen, Pul, Refik, Walter, Annette, Zettl, Uwe, Senel, Makbule, Stellmann, Jan-Patrick, Häußler, Vivien, Hellwig, Kerstin, Ayzenberg, Ilya, Aktas, Orhan, Ringelstein, Marius, Schreiber-Katz, Olivia, Trebst, Corinna, Department of Neurology, Hannover Medical School, Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background and Objectives To evaluate costs and health-related quality of life (HRQoL) of neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods In this multicenter cross-sectional study, data on consumption of medical and nonmedical resources and work ability were assessed via patient questionnaires. Costs were analyzed in Euros for 2018 from the societal perspective. HRQoL was captured by the EuroQoL Group 5 Dimension 5 Level Scale (EQ-5D-5L) questionnaire. Clinical data were retrieved from the Neuromyelitis Optica Study Group (NEMOS) database. Results Two hundred twelve patients (80% women, median age 50 [19-83] years, median disease duration 7 [0-43] years, median Expanded Disability Status Scale [EDSS] score 3.5 [0-8.5], 66% aquaporin-4 immunoglobulin G [IgG] positive, 22% MOG IgG positive, 12% double seronegative) were analyzed. The mean total annual per capita cost of illness accounted for €59,574 (95% CI 51,225-68,293 or US dollars [USD] 70,297, 95% CI 60,445-80,586), and the mean index value of the EQ-5D-5L was 0.693 (95% CI 0.65-0.73). The most important cost drivers were informal care costs (28% of total costs), indirect costs (23%), and drugs (16%)

Published
2022
Full Text
View/download PDF

67. Additional file 1 of Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Author

Jarius, Sven, Pache, Florence, K��rtvelyessy, Peter, Jel��i��, Ilijas, Stettner, Mark, Franciotta, Diego, Keller, Emanuela, Neumann, Bernhard, Ringelstein, Marius, Senel, Makbule, Regeniter, Axel, Kalantzis, Rea, Willms, Jan F., Berthele, Achim, Busch, Markus, Capobianco, Marco, Eisele, Amanda, Reichen, Ina, Dersch, Rick, Rauer, Sebastian, Sandner, Katharina, Ayzenberg, Ilya, Gross, Catharina C., Hegen, Harald, Khalil, Michael, Kleiter, Ingo, Lenhard, Thorsten, Haas, J��rgen, Aktas, Orhan, Angstwurm, Klemens, Kleinschnitz, Christoph, Lewerenz, Jan, Tumani, Hayrettin, Paul, Friedemann, Stangel, Martin, Ruprecht, Klemens, and Wildemann, Brigitte

Abstract

Additional file 1. Table S1. Patient and subgroup characteristics.

Published
2022
Full Text
View/download PDF

68. Additional file 2 of Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD

Author

Schroeder-Castagno, Maria, Del Rio-Serrato, Alba, Wilhelm, Andreas, Romero-Suárez, Silvina, Schindler, Patrick, Alvarez-González, Cesar, Duchow, Ankelien-Solveig, Bellmann-Strobl, Judith, Ruprecht, Klemens, Hastermann, Maria, Grütz, Gerald, Wildemann, Brigitte, Jarius, Sven, Schmitz-Hübsch, Tanja, Paul, Friedemann, and Infante-Duarte, Carmen

Abstract

Additional file 2: Figure S2. Evaluation of spontaneous and PMA induced ROS production in AQP4 + NMOSD, MOGAD patients and HC granulocytes. Granulocytes from patients and matched HC were isolated and analyzed simultaneously and cultured without (black dots, none) and with PMA (red dots). Intracellular ROS were indirectly assessed by flow cytometry analysis of DHR 123. Depicted is the mean fluorescence intensity (MFI) of oxidized-DHR123. A) Data are represented with lines connecting the unstimulated and PMA-stimulated data points of the same patient sample B) Depicted are the data from unstimulated and MOGAD samples in a different scale to show group differences. Each dot represents an individual subject. HC: n = 17; AQP4 + NMOSD: n = 9; MOGAD: n = 8.

Published
2022
Full Text
View/download PDF

69. Additional file 3 of Impaired response of blood neutrophils to cell-death stimulus differentiates AQP4-IgG-seropositive NMOSD from MOGAD

Author

Schroeder-Castagno, Maria, Del Rio-Serrato, Alba, Wilhelm, Andreas, Romero-Suárez, Silvina, Schindler, Patrick, Alvarez-González, Cesar, Duchow, Ankelien-Solveig, Bellmann-Strobl, Judith, Ruprecht, Klemens, Hastermann, Maria, Grütz, Gerald, Wildemann, Brigitte, Jarius, Sven, Schmitz-Hübsch, Tanja, Paul, Friedemann, and Infante-Duarte, Carmen

Abstract

Additional file 3: Figure S3. Evaluation of serum cytokines and chemokines in AQP4 + NMOSD, MOGAD patients and HC. Levels of GM-CSF (A), IL-6 (B), IL-8 (C), IL-15 (D), TNF-alpha (E) and IL-10 (F) were investigated using the Meso Scale Diagnostics MULTISPOT Assay System in serum samples from AQP4 + NMOSD (left panel) and MOGAD (right panel) patients compared with their respective HC. Data are represented as median and IQR in scatter plot with a bar graph. Each dot represents an individual subject. HC: n = 37; AQP4 + NMOSD: n = 24; MOGAD: n = 13.

Published
2022
Full Text
View/download PDF

75. Neuromyelitis Optica: Evaluation of 871 Attacks and 1,153 Treatment Courses

Author

Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Wegner, Brigitte, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Krumbholz, Markus, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Winkelmann, Alexander, Marouf, Wael, Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, and Trebst, Corinna

Published
2016
Full Text
View/download PDF

76. Clinical, serological and genetic predictors of response to immunotherapy in anti-IgLON5 disease.

Author

Grüter, Thomas, Möllers, Franziska E, Tietz, Anja, Dargvainiene, Justina, Melzer, Nico, Heidbreder, Anna, Strippel, Christine, Kraft, Andrea, Höftberger, Romana, Schöberl, Florian, Thaler, Franziska S, Wickel, Jonathan, Chung, Ha-Yeun, Seifert, Frank, Tschernatsch, Marlene, Nagel, Michael, Lewerenz, Jan, Jarius, Sven, Wildemann, Brigitte C, and Azevedo, Lucie de

Subjects
GLIAL fibrillary acidic protein, AUTOIMMUNE diseases, IMMUNOTHERAPY, BLOOD proteins, ATTENTION-deficit hyperactivity disorder, DISEASE exacerbation
Abstract

Anti-IgLON5 disease is a newly defined clinical entity characterized by a progressive course with high disability and mortality rate. While precise pathogenetic mechanisms remain unclear, features characteristic of both autoimmune and neurodegenerative diseases were reported. Data on immunotherapy are limited, and its efficacy remains controversial. In this study, we retrospectively investigated an anti-IgLON5 disease cohort with special focus on clinical, serological and genetic predictors of the immunotherapy response and long-term outcome. Patients were recruited from the GENERATE (German Network for Research on Autoimmune Encephalitis) registry. Along with clinical parameters, anti-IgLON5 immunoglobulin (Ig)G in serum and CSF, anti-IgLON5 IgG1-4, IgA and IgM in serum, neurofilament light chain and glial fibrillary acidic protein in serum as well as human leukocyte antigen-genotypes were determined. We identified 53 patients (symptom onset 63.8 ± 10.3 years, female:male 1:1.5). The most frequent initial clinical presentations were bulbar syndrome, hyperkinetic syndrome or isolated sleep disorder [at least one symptom present in 38% (20/53)]. At the time of diagnosis, the majority of patients had a generalized multi-systemic phenotype; nevertheless, 21% (11/53) still had an isolated brainstem syndrome and/or a characteristic sleep disorder only. About one third of patients [28% (15/53)] reported subacute disease onset and 51% (27/53) relapse-like exacerbations during the disease course. Inflammatory CSF changes were evident in 37% (19/51) and increased blood-CSF-barrier permeability in 46% (21/46). CSF cell count significantly decreased, while serum anti-IgLON5 IgG titre increased with disease duration. The presence of human leukocyte antigen-DRB1*10:01 [55% (24/44)] was associated with higher serum anti-IgLON5 IgG titres. Neurofilament light chain and glial fibrillary acidic protein in serum were substantially increased (71.1 ± 103.9 pg/ml and 126.7 ± 73.3 pg/ml, respectively). First-line immunotherapy of relapse-like acute-to-subacute exacerbation episodes resulted in improvement in 41% (11/27) of patients and early initiation within the first 6 weeks was a predictor for therapy response. Sixty-eight per cent (36/53) of patients were treated with long-term immunotherapy and 75% (27/36) of these experienced no further disease progression (observation period of 20.2 ± 15.4 months). Long-term immunotherapy initiation during the first year after onset and low pre-treatment neurofilament light chain were significant predictors for a better outcome. In conclusion, subacute disease onset and early inflammatory CSF changes support the primary role of autoimmune mechanisms at least at initial stages of anti-IgLON5 disease. Early immunotherapy, prior to advanced neurodegeneration, is associated with a better long-term clinical outcome. Low serum neurofilament light chain at treatment initiation may serve as a potential biomarker of the immunotherapy response. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

77. Glial fibrillary acidic protein as a biomarker in neuromyelitis optica spectrum disorder: a current review.

Author

Schindler, Patrick, Aktas, Orhan, Ringelstein, Marius, Wildemann, Brigitte, Jarius, Sven, Paul, Friedemann, and Ruprecht, Klemens

Subjects
NEUROMYELITIS optica, GLIAL fibrillary acidic protein, TRANSVERSE myelitis, OPTIC neuritis, BIOMARKERS, SYMPTOMS
Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, often debilitating neuroinflammatory disease, whose predominant clinical manifestations are longitudinally extensive transverse myelitis and optic neuritis. About 80% of the patients with an NMOSD phenotype have pathogenic autoantibodies against the astrocyte water channel aquaporin-4 (AQP4-IgG). While therapeutic options for NMOSD have greatly expanded in recent years, well-established biomarkers for prognosis or treatment response are still lacking. Glial fibrillary acidic protein (GFAP) is mainly expressed in astrocytes and can be detected in cerebrospinal fluid (CSF) and blood of patients with NMOSD. Here, we comprehensively review the current knowledge on GFAP as a biomarker in NMOSD. In patients with AQP4-IgG+ NMOSD, GFAP levels are elevated in CSF and serum during acute attacks and correlate with disability, consistent with the pathophysiology of this antibody-mediated astrocytopathy. Serum GFAP levels tend to be higher in AQP4-IgG+ NMOSD than in its differential diagnoses, multiple sclerosis, and myelin oligodendrocyte antibody-associated disease. Importantly, serum GFAP levels in AQP4-IgG+ NMOSD during remission may be predictive of future disease activity. Serial serum GFAP measurements are emerging as a biomarker to monitor disease activity in AQP4-IgG+ NMOSD and could have the potential for application in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

79. Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients

Author

Jarius, Sven, Lechner, Christian, Wendel, Eva M, Baumann, Matthias, Breu, Markus, Schimmel, Mareike, Karenfort, Michael, Marina, Adela Della, Merkenschlager, Andreas, Thiels, Charlotte, Blaschek, Astrid, Salandin, Michela, Leiz, Steffen, Leypoldt, Frank, Pschibul, Alexander, Hackenberg, Annette, Hahn, Andreas, Syrbe, Steffen, Strautmanis, Jurgis, Häusler, Martin, Krieg, Peter, Eisenkölbl, Astrid, Stoffels, Johannes, Eckenweiler, Matthias, Ayzenberg, Ilya, Haas, Jürgen, Höftberger, Romana, Kleiter, Ingo, Korporal-Kuhnke, Mirjam, et al, University of Zurich, and Jarius, Sven

Subjects
2403 Immunology, Cellular and Molecular Neuroscience, Neurology, 10036 Medical Clinic, 2808 Neurology, General Neuroscience, Immunology, 2804 Cellular and Molecular Neuroscience, 2800 General Neuroscience, 610 Medicine & health
Published
2020

80. Neurofilament ELISA validation

Author

Petzold, Axel, Altintas, Ayse, Andreoni, Laura, Bartos, Ales, Berthele, Achim, Blankenstein, Marinus A., Buee, Luc, Castellazzi, Massimiliano, Cepok, Sabine, Comabella, Manuel, Constantinescu, Cris S., Deisenhammer, Florian, Deniz, Gunnur, Erten, Gaye, Espiño, Mercedes, Fainardi, Enrico, Franciotta, Diego, Freedman, Mark S., Giedraitis, Vilmantas, Gilhus, Nils Erik, Giovannoni, Gavin, Glabinski, Andrzej, Grieb, Pawel, Hartung, Hans-Peter, Hemmer, Bernhard, Herukka, Sanna-Kaisa, Hintzen, Rogier, Ingelsson, Martin, Jackson, Samuel, Jacobsen, Steve, Jafari, Naghmeh, Jalosinski, Marcin, Jarius, Sven, Kapaki, Elisabeth, Kieseier, Bernd C., Koel-Simmelink, Marleen J.A., Kornhuber, Johannes, Kuhle, Jens, Kurzepa, Jacek, Lalive, Patrice H., Lannfelt, Lars, Lehmensiek, Vera, Lewczuk, Piotr, Livrea, Paolo, Marnetto, Fabiana, Martino, Davide, Menge, Til, Norgren, Niklas, Papuć, Eva, Paraskevas, George P., Pirttilä, Tuula, Rajda, Cecília, Rejdak, Konrad, Ricny, Jan, Ripova, Daniela, Rosengren, Lars, Ruggieri, Maddalena, Schraen, Susanna, Shaw, Gerry, Sindic, Christian, Siva, Aksel, Stigbrand, Torgny, Stonebridge, Iva, Topcular, Baris, Trojano, Maria, Tumani, Hayrettin, Twaalfhoven, Harry A.M., Vécsei, László, Van Pesch, Vincent, Vanderstichele, Hugo, Vedeler, Christian, Verbeek, Marcel M., Villar, Luisa Maria, Weissert, Robert, Wildemann, Brigitte, Yang, Cui, Yao, Karen, and Teunissen, Charlotte E.

Published
2010
Full Text
View/download PDF

81. COVID-19-related severe MS exacerbation with life-threatening Takotsubo cardiomyopathy in a previously stable patient and interference of MS therapy with long-term immunity against SARS-CoV-2

Author

Wildemann, Brigitte, primary, Jarius, Sven, additional, Lehmann, Lorenz H., additional, André, Florian, additional, Frey, Norbert, additional, Schnitzler, Paul, additional, Jäger, Laura, additional, Gumbinger, Christoph, additional, and Viehöver, Andrea, additional

Published
2021
Full Text
View/download PDF

82. VIEWPOINT: Neurology—the next 10 years

Author

Baron, Ralf, Ferriero, Donna M., Frisoni, Giovanni B., Bettegowda, Chetan, Gokaslan, Ziya L., Kessler, John A., Vezzani, Annamaria, Waxman, Stephen G., Jarius, Sven, Wildemann, Brigitte, and Weller, Michael

Published
2015
Full Text
View/download PDF

84. Immunopathogenesis of Neuromyelitis Optica

Author

Levy, Michael, primary, Wildemann, Brigitte, additional, Jarius, Sven, additional, Arellano, Benjamine, additional, Sasidharan, Saranya, additional, Weber, Martin S., additional, and Stuve, Olaf, additional

Published
2014
Full Text
View/download PDF

90. Eculizumab Use in Neuromyelitis Optica Spectrum Disorders

Author

Ringelstein, Marius, Asseyer, Susanna, Lindenblatt, Gero, Fischer, Katinka, Pul, Refik, Skuljec, Jelena, Revie, Lisa, Giglhuber, Katrin, Häußler, Vivien, Karenfort, Michael, Hellwig, Kerstin, Paul, Friedemann, Bellmann-Strobl, Judith, Otto, Carolin, Ruprecht, Klemens, Ziemssen, Tjalf, Emmer, Alexander, Rothhammer, Veit, Nickel, Florian T., Angstwurm, Klemens, Linker, Ralf, Laurent, Sarah A., Warnke, Clemens, Jarius, Sven, Korporal-Kuhnke, Mirjam, Wildemann, Brigitte, Wolff, Stephanie, Seipelt, Maria, Yalachkov, Yavor, Retzlaff, Nele, Zettl, Uwe K., Rommer, Paulus S., Kowarik, Markus C., Wickel, Jonathan, Geis, Christian, Hümmert, Martin W., Trebst, Corinna, Senel, Makbule, Gold, Ralf, Klotz, Luisa, Kleinschnitz, Christoph, Meuth, Sven G., Aktas, Orhan, Berthele, Achim, and Ayzenberg, Ilya

Published
2024
Full Text
View/download PDF

91. Pain, Depression, and Quality of Life in Neuromyelitis Optica Spectrum Disorder

Author

Ayzenberg, Ilya, Richter, Daniel, Henke, Eugenia, Asseyer, Susanna, Paul, Friedemann, Trebst, Corinna, Hümmert, Martin W., Havla, Joachim, Kümpfel, Tania, Ringelstein, Marius, Aktas, Orhan, Wildemann, Brigitte, Jarius, Sven, Häußler, Vivien, Stellmann, Jan-Patrick, Senel, Makbule, Klotz, Luisa, Pellkofer, Hannah L., Weber, Martin S., Pawlitzki, Marc, Rommer, Paulus S., Berthele, Achim, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Gold, Ralf, and Kleiter, Ingo

Subjects
ddc
Published
2020

92. Differences in advanced magnetic resonance imaging in MOG-IgG and AQP4-IgG seropositive neuromyelitis optica spectrum disorders: a comparative study

Author

Schmidt, Felix A., Chien, Claudia, Kuchling, Joseph, Bellmann-Strobl, Judith, Ruprecht, Klemens, Siebert, Nadja, Asseyer, Susanna, Jarius, Sven, Brandt, Alexander U., Scheel, Michael, and Paul, Friedemann

Subjects
Neurology, nervous system, DTI, advanced imaging, NMOSD, MOG, sense organs, Function and Dysfunction of the Nervous System, AQP4, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Original Research, MRI
Abstract

Aims: To explore differences in advanced brain magnetic resonance imaging (MRI) characteristics between myelin oligodendrocyte (MOG) immunoglobulin (IgG) and aquaporin-4 (AQP4) IgG seropositive (+) neuromyelitis optica spectrum disorders (NMOSD). Methods: 33 AQP4-IgG and 18 MOG-IgG seropositive NMOSD patients and 61 healthy control (HC) subjects were included. All 112 participants were scanned with the same standardized MRI-protocol on a 3-Tesla MRI-scanner. Brain volume and diffusion tensor imaging (DTI) parameters were assessed. Results: MOG-IgG+ patients showed reduced parallel diffusivity within white matter tracts compared to HC whereas AQP4-IgG+ showed no significant brain parenchymal damage in DTI analysis. AQP4-IgG+ patients showed reduced whole brain volumes and reduced volumes of several deep gray matter structures compared to HC whereas MOG-IgG+ patients did not show reduced brain or deep gray matter volumes compared to HC. Conclusions: Microstructural brain parenchymal damage in MOG-IgG+ patients was more pronounced than in AQP4-IgG+ patients, compared with HC, whereas normalized brain volume reduction was more severe in AQP4-IgG+ patients. Longitudinal imaging studies are warranted to further investigate this trend in NMOSD. Our results suggest that MOG-IgG+ and AQP4-IgG+ NMOSD patients differ in cerebral MRI characteristics. Advanced MRI analysis did not help to differentiate between MOG-IgG+ and AQP4-IgG+ patients in our study.

Published
2020

93. Additional file 7 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

Author

Jarius, Sven, Pellkofer, Hannah, Siebert, Nadja, Korporal-Kuhnke, Mirjam, Hümmert, Martin W., Ringelstein, Marius, Rommer, Paulus S., Ayzenberg, Ilya, Ruprecht, Klemens, Klotz, Luisa, Asgari, Nasrin, Zrzavy, Tobias, Höftberger, Romana, Tobia, Rafik, Buttmann, Mathias, Fechner, Kai, Schanda, Kathrin, Weber, Martin, Asseyer, Susanna, Haas, Jürgen, Lechner, Christian, Kleiter, Ingo, Aktas, Orhan, Trebst, Corinna, Rostasy, Kevin, Reindl, Markus, Kümpfel, Tania, Paul, Friedemann, and Wildemann, Brigitte

Abstract

Additional file 7: Supplementary Figure 3. Regression analysis of QAlb and CSF total protein demonstrated a close relationship between the two parameters (r2=0.75, p

Published
2020
Full Text
View/download PDF

94. Additional file 1 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

Author

Jarius, Sven, Pellkofer, Hannah, Siebert, Nadja, Korporal-Kuhnke, Mirjam, Hümmert, Martin W., Ringelstein, Marius, Rommer, Paulus S., Ayzenberg, Ilya, Ruprecht, Klemens, Klotz, Luisa, Asgari, Nasrin, Zrzavy, Tobias, Höftberger, Romana, Tobia, Rafik, Buttmann, Mathias, Fechner, Kai, Schanda, Kathrin, Weber, Martin, Asseyer, Susanna, Haas, Jürgen, Lechner, Christian, Kleiter, Ingo, Aktas, Orhan, Trebst, Corinna, Rostasy, Kevin, Reindl, Markus, Kümpfel, Tania, Paul, Friedemann, and Wildemann, Brigitte

Abstract

Additional file 1: Supplementary Table 1. CSF findings during acute attacks and during remission in the ‘acute MY subgroup’, the ‘acute ON subgroup’ and the ‘acute BRAIN subgroup’ (stratified results from Table 11).

Published
2020
Full Text
View/download PDF

95. Additional file 4 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients

Author

Jarius, Sven, Lechner, Christian, Wendel, Eva M., Baumann, Matthias, Breu, Markus, Schimmel, Mareike, Karenfort, Michael, Marina, Adela Della, Merkenschlager, Andreas, Thiels, Charlotte, Blaschek, Astrid, Salandin, Michela, Leiz, Steffen, Leypoldt, Frank, Pschibul, Alexander, Hackenberg, Annette, Hahn, Andreas, Syrbe, Steffen, Strautmanis, Jurgis, Häusler, Martin, Krieg, Peter, Eisenkölbl, Astrid, Stoffels, Johannes, Eckenweiler, Matthias, Ayzenberg, Ilya, Haas, Jürgen, Höftberger, Romana, Kleiter, Ingo, Korporal-Kuhnke, Mirjam, Ringelstein, Marius, Ruprecht, Klemens, Siebert, Nadja, Schanda, Kathrin, Aktas, Orhan, Paul, Friedemann, Reindl, Markus, Wildemann, Brigitte, and Rostásy, Kevin

Abstract

Additional file 4: Supplementary Figure 4. Influence of age at LP on CSF parameters as detected by a pooled linear regression analysis of data from the pediatric and the adult cohort (r2=0.089 for CSF TP, p

Published
2020
Full Text
View/download PDF

96. Additional file 5 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients

Author

Jarius, Sven, Lechner, Christian, Wendel, Eva M., Baumann, Matthias, Breu, Markus, Schimmel, Mareike, Karenfort, Michael, Marina, Adela Della, Merkenschlager, Andreas, Thiels, Charlotte, Blaschek, Astrid, Salandin, Michela, Leiz, Steffen, Leypoldt, Frank, Pschibul, Alexander, Hackenberg, Annette, Hahn, Andreas, Syrbe, Steffen, Strautmanis, Jurgis, Häusler, Martin, Krieg, Peter, Eisenkölbl, Astrid, Stoffels, Johannes, Eckenweiler, Matthias, Ayzenberg, Ilya, Haas, Jürgen, Höftberger, Romana, Kleiter, Ingo, Korporal-Kuhnke, Mirjam, Ringelstein, Marius, Ruprecht, Klemens, Siebert, Nadja, Schanda, Kathrin, Aktas, Orhan, Paul, Friedemann, Reindl, Markus, Wildemann, Brigitte, and Rostásy, Kevin

Abstract

Additional file 5: Supplementary Table 1. CSF findings during acute attacks and during remission in the ‘acute MY’ subgroup, the ‘acute ON’ subgroup and the ‘acute BRAIN’ subgroup (stratified results from Table 10).

Published
2020
Full Text
View/download PDF

97. Additional file 8 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients

Author

Jarius, Sven, Lechner, Christian, Wendel, Eva M., Baumann, Matthias, Breu, Markus, Schimmel, Mareike, Karenfort, Michael, Marina, Adela Della, Merkenschlager, Andreas, Thiels, Charlotte, Blaschek, Astrid, Salandin, Michela, Leiz, Steffen, Leypoldt, Frank, Pschibul, Alexander, Hackenberg, Annette, Hahn, Andreas, Syrbe, Steffen, Strautmanis, Jurgis, Häusler, Martin, Krieg, Peter, Eisenkölbl, Astrid, Stoffels, Johannes, Eckenweiler, Matthias, Ayzenberg, Ilya, Haas, Jürgen, Höftberger, Romana, Kleiter, Ingo, Korporal-Kuhnke, Mirjam, Ringelstein, Marius, Ruprecht, Klemens, Siebert, Nadja, Schanda, Kathrin, Aktas, Orhan, Paul, Friedemann, Reindl, Markus, Wildemann, Brigitte, and Rostásy, Kevin

Subjects
nervous system, immune system diseases, mental disorders, hemic and immune systems, nervous system diseases
Abstract

Additional file 8: Supplementary Table 4. CSF findings in MOG-IgG-positive acute bilateral ON and in MOG-IgG-positive acute unilateral ON.

Published
2020
Full Text
View/download PDF

98. Additional file 6 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

Author

Jarius, Sven, Pellkofer, Hannah, Siebert, Nadja, Korporal-Kuhnke, Mirjam, Hümmert, Martin W., Ringelstein, Marius, Rommer, Paulus S., Ayzenberg, Ilya, Ruprecht, Klemens, Klotz, Luisa, Asgari, Nasrin, Zrzavy, Tobias, Höftberger, Romana, Tobia, Rafik, Buttmann, Mathias, Fechner, Kai, Schanda, Kathrin, Weber, Martin, Asseyer, Susanna, Haas, Jürgen, Lechner, Christian, Kleiter, Ingo, Aktas, Orhan, Trebst, Corinna, Rostasy, Kevin, Reindl, Markus, Kümpfel, Tania, Paul, Friedemann, and Wildemann, Brigitte

Abstract

Additional file 6: Supplementary Figure 2. No statistically significant differences in serum IgG, IgM, IgA and albumin levels between the ‘acute MY’, the ‘acute ON’ and the ‘acute BRAIN’ (B) subgroup.

Published
2020
Full Text
View/download PDF

99. Additional file 4 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients

Author

Jarius, Sven, Pellkofer, Hannah, Siebert, Nadja, Korporal-Kuhnke, Mirjam, Hümmert, Martin W., Ringelstein, Marius, Rommer, Paulus S., Ayzenberg, Ilya, Ruprecht, Klemens, Klotz, Luisa, Asgari, Nasrin, Zrzavy, Tobias, Höftberger, Romana, Tobia, Rafik, Buttmann, Mathias, Fechner, Kai, Schanda, Kathrin, Weber, Martin, Asseyer, Susanna, Haas, Jürgen, Lechner, Christian, Kleiter, Ingo, Aktas, Orhan, Trebst, Corinna, Rostasy, Kevin, Reindl, Markus, Kümpfel, Tania, Paul, Friedemann, and Wildemann, Brigitte

Subjects
nervous system, immune system diseases, mental disorders, hemic and immune systems, nervous system diseases
Abstract

Additional file 4: Supplementary Table 4. CSF findings in MOG-IgG-positive acute bilateral ON and in MOG-IgG-positive acute unilateral ON.

Published
2020
Full Text
View/download PDF

100. Additional file 2 of Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients

Author

Jarius, Sven, Lechner, Christian, Wendel, Eva M., Baumann, Matthias, Breu, Markus, Schimmel, Mareike, Karenfort, Michael, Marina, Adela Della, Merkenschlager, Andreas, Thiels, Charlotte, Blaschek, Astrid, Salandin, Michela, Leiz, Steffen, Leypoldt, Frank, Pschibul, Alexander, Hackenberg, Annette, Hahn, Andreas, Syrbe, Steffen, Strautmanis, Jurgis, Häusler, Martin, Krieg, Peter, Eisenkölbl, Astrid, Stoffels, Johannes, Eckenweiler, Matthias, Ayzenberg, Ilya, Haas, Jürgen, Höftberger, Romana, Kleiter, Ingo, Korporal-Kuhnke, Mirjam, Ringelstein, Marius, Ruprecht, Klemens, Siebert, Nadja, Schanda, Kathrin, Aktas, Orhan, Paul, Friedemann, Reindl, Markus, Wildemann, Brigitte, and Rostásy, Kevin

Abstract

Additional file 2: Supplementary Figure 2. No marked differences in serum IgG, IgM, IgA and albumin levels between the ‘acute MY’, the ‘acute ON’ and the ‘acute BRAIN’ (B) subgroup, except for slightly higher median IgM values in the ‘acute BRAIN’ subgroup as compared to the acute ‘ON’ subgroup.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results