Search

Your search keyword '"Jeng, Long‐Bin"' showing total 776 results
Start Over Author "Jeng, Long‐Bin"
776 results on '"Jeng, Long‐Bin"'

58. Non‐Contrast‐Enhanced MR Arteriography of Potential Living‐Related Liver Donor: Using Contrast Enhanced CT Arteriography as Standard Reference

Author

Lin, Wei‐Ching, primary, Chen, Chun‐Ming, additional, Westphalen, Antonio Carlos, additional, Lin, Tzu‐Yang, additional, Chang, Chia Hao, additional, Chen, Li‐Kuang, additional, Lin, Chia‐Wei, additional, Yeh, Chun‐Chieh, additional, Yu, Jiaxin, additional, Jeng, Long‐Bin, additional, and Chen, Jeon‐Hor, additional

Published
2022
Full Text
View/download PDF

59. Integrated genomic analyses of hepatocellular carcinoma

Author

Chang, Ya-Sian, primary, Tu, Siang-Jyun, additional, Chen, Hong-Da, additional, Hsu, Ming-Hon, additional, Chen, Yu-Chia, additional, Chao, Dy-San, additional, Chung, Chin-Chun, additional, Chou, Yu-Pao, additional, Chang, Chieh-Min, additional, Lee, Ya-Ting, additional, Yen, Ju-Chen, additional, Jeng, Long-Bin, additional, and Chang, Jan-Gowth, additional

Published
2022
Full Text
View/download PDF

60. Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipients with Hepatocellular Carcinoma

Author

Sapisochin, Gonzalo, primary, Lee, Wei Chen, additional, Joo, Dong Jin, additional, Joh, Jae-Won, additional, Hata, Koichiro, additional, Soin, Arvinder Singh, additional, Veldandi, Uday Kiran, additional, Kaneko, Shuhei, additional, Meier, Matthias, additional, Leclair, Denise, additional, Sunkara, Gangadhar, additional, and Jeng, Long Bin, additional

Published
2022
Full Text
View/download PDF

64. Non‐Contrast‐Enhanced MR Arteriography of Potential Living‐Related Liver Donor: Using Contrast Enhanced CT Arteriography as Standard Reference.

Author

Lin, Wei‐Ching, Chen, Chun‐Ming, Westphalen, Antonio Carlos, Lin, Tzu‐Yang, Chang, Chia Hao, Chen, Li‐Kuang, Lin, Chia‐Wei, Yeh, Chun‐Chieh, Yu, Jiaxin, Jeng, Long‐Bin, and Chen, Jeon‐Hor

Subjects
MAGNETIC resonance angiography, ARTERIOGRAPHY, WILCOXON signed-rank test, HEPATIC artery, CONTRAST media, IMAGE enhancement (Imaging systems), CONTRAST-enhanced magnetic resonance imaging
Abstract

Background: Contrast‐enhanced computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are the primary modalities to assess donors' vessels before transplant surgery. Radiation and contrast medium are potentially harmful to donors. Purpose: To compare the image quality and visualization scores of hepatic arteries on CTA and balanced steady‐state free‐precession (bSSFP) non‐contrast‐enhanced MRA (NC‐MRA), and to evaluate if bSSFP NC‐MRA can potentially be a substitute for CTA. Study Type: Prospective. Population: Fifty‐six consecutive potential living‐related liver donors (30.9 ± 8.4 years; 31 men). Field Strength/Sequence: 1.5T; four bSSFP NC‐MRA sequences: respiratory‐triggered (Inhance inflow inversion recovery [IFIR]) and three breath‐hold (BH); and CTA. Assessment: The artery‐to‐liver contrast (Ca‐l) was quantified. Three radiologists independently assigned visualization scores using a four‐point scale to potential origins, segments, and branches of the hepatic arteries, determined the anatomical variants based on Hiatt's classification, and assessed the image quality of NC‐MRA sequences. Statistical Tests: Fleiss' kappa to evaluate the readers' agreement. Repeat measured ANOVA or Friedman test to compare Ca‐l of each NC‐MRA. Friedman test to compare overall image quality and visualization scores; post hoc analysis using Wilcoxon signed‐rank test. P‐value <0.05 was considered statistically significant. Results: Inhance IFIR Ca‐l was significantly higher than all BH bSSFP Ca‐l (0.56 [0.45–0.64] vs. 0.37 [0.29–0.47] to 0.41 [0.23–0.51]). Overall image quality score of BH bSSFP TI1200 was significantly higher than other NC‐MRA (4 [4–4] vs. 4 [3 to 4–4]). The median visualization scores of almost all arteries on CTA were significantly higher than on NC‐MRA (4 [3 to 4–4] vs. 1 [1–2] to 4 [4–4]). The median visualization scores were all 4 [4–4 ] on Inhance IFIR with >92.3% observed scores ≥3, except the segment 4 branch (3 [1–4], 53.6%). The identification rates of arterial variants were 92.9%–97% on Inhance IFIR. Data Conclusions: Although CTA is superior to the NC‐MRA, all NC‐MRA depict the donor arterial anatomy well. Inhance IFIR can potentially be an alternative image modality for CTA to evaluate the arterial variants of living donors. Level of Evidence: 3 Technical Efficacy: Stage 2 [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

67. Mesenchymal stem cell therapy on top of triple therapy with remdesivir, dexamethasone, and tocilizumab improves PaO2/FiO2 in severe COVID-19 pneumonia

Author

Chen, Chih-Hao, primary, Chang, Kuan-Cheng, additional, Lin, Yen-Nien, additional, Ho, Mao-Wang, additional, Cheng, Meng-Yu, additional, Shih, Wen-Hsin, additional, Chou, Chia-Huei, additional, Lin, Po-Chang, additional, Chi, Chih-Yu, additional, Lu, Min-Chi, additional, Tien, Ni, additional, Wu, Mei-Yao, additional, Chang, Shih-Sheng, additional, Hsu, Wu-Huei, additional, Shyu, Woei-Cheang, additional, Cho, Der-Yang, additional, and Jeng, Long-Bin, additional

Published
2022
Full Text
View/download PDF

70. First-in-human pilot trial of combined intracoronary and intravenous mesenchymal stem cell therapy in acute myocardial infarction

Author

Hsiao, Lien-Cheng, primary, Lin, Yen-Nien, additional, Shyu, Woei-Cherng, additional, Ho, Ming, additional, Lu, Chiung-Ray, additional, Chang, Shih-Sheng, additional, Wang, Yu-Chen, additional, Chen, Jan-Yow, additional, Lu, Shang-Yeh, additional, Wu, Mei-Yao, additional, Li, Keng-Yuan, additional, Lin, Yu-Kai, additional, Tseng, Wen-Yih I., additional, Su, Mao-Yuan, additional, Hsu, Chin-Ting, additional, Tsai, Cheng-Kang, additional, Chiu, Lu-Ting, additional, Chen, Chien-Lin, additional, Lin, Cheng-Li, additional, Hu, Kai-Chieh, additional, Cho, Der-Yang, additional, Tsai, Chang-Hai, additional, Chang, Kuan-Cheng, additional, and Jeng, Long-Bin, additional

Published
2022
Full Text
View/download PDF

71. Increased Expression of Programmed Death Ligand 1 in Hepatocellular Carcinoma of Patients with Hepatitis B Virus Pre-S2 Mutant

Author

Teng, Chiao-Fang, Li, Tsai-Chung, Wang, Ting, Wu, Tzu-Hua, Wang, John, Wu, Han-Chieh, Shyu, Woei-Cherng, Su, Ih-Jen, and Jeng, Long-Bin

Subjects
pre-S2 mutant, programmed death 1, programmed death ligand 1, hepatocellular carcinoma, hepatitis B virus, Journal of Hepatocellular Carcinoma, digestive system diseases, Original Research
Abstract

Chiao-Fang Teng,1– 3 Tsai-Chung Li,4,5 Ting Wang,2 Tzu-Hua Wu,2 John Wang,6 Han-Chieh Wu,7 Woei-Cherng Shyu,1,8– 10 Ih-Jen Su,11 Long-Bin Jeng2 1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; 2Organ Transplantation Center, China Medical University Hospital, Taichung, Taiwan; 3Research Center for Cancer Biology, China Medical University, Taichung, Taiwan; 4Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan; 5Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan; 6Department of Pathology, China Medical University Hospital, Taichung, Taiwan; 7National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan; 8Department of Occupational Therapy, Asia University, Taichung, Taiwan; 9Department of Neurology, China Medical University Hospital, Taichung, Taiwan; 10Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; 11Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, TaiwanCorrespondence: Chiao-Fang TengGraduate Institute of Biomedical Sciences, China Medical University, No. 91, Hsueh-Shih Road, Northern Dist., Taichung City 404, TaiwanTel + 886-4-2205-2121Fax + 886-4-2202-9083Email chiaofangteng@gmail.comLong-Bin JengOrgan Transplantation Center, China Medical University Hospital, No. 2, Yude Road, Northern Dist., Taichung City 404, TaiwanTel + 886-4-2205-2121Fax + 886-4-2202-9083Email longbin.cmuh@gmail.comPurpose: Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC), a leading cause of cancer-related death worldwide. The HCC patients who harbor HBV pre-S2 mutant, an oncoprotein that plays key roles in HCC development, have been closely associated with a worse prognosis after curative surgical resection, suggesting an urgent need for alternative therapeutic options to improve their survival. In this study, we aimed to evaluate the expression profiles of programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1), two of the most well-studied immune checkpoint molecules that promote tumor immune evasion, in tumor of the pre-S2 mutant-positive/high HCC patients.Methods: We classified 40 HBV-related HCC patients into the pre-S2-positive/high and -negative/low groups by a next-generation sequencing-based approach. The fluorescent immunohistochemistry staining was performed to detect the expression of PD-1 and PD-L1 in HCC tissues of patients.Results: We showed that patients with either deletion spanning pre-S2 gene segment or high percentage of pre-S2 plus pre-S1+pre-S2 deletion (the pre-S2 mutant-positive/high group) exhibited a significantly higher density of PD-L1-positive cells in HCC tissues than those without. Moreover, the percentage of pre-S2 plus pre-S1+pre-S2 deletion displayed a high positive correlation with the density of PD-L1-positive cells in HCC tissues.Conclusion: The increased expression of PD-L1 in tumor tissues of the pre-S2 mutant-positive HCC patients suggest that pre-S2 mutant may play a potential role in dysregulation of tumor immune microenvironment in the progression of HBV-related HCC, implicating for the development of future therapeutic strategies.Keywords: hepatitis B virus, hepatocellular carcinoma, pre-S2 mutant, programmed death 1, programmed death ligand 1

Published
2020

88. Contribution of matrix metalloproteinases-1 genotypes to gastric cancer susceptibility in Taiwan

Author

Yang Mei-Due, Lin Kuo-Cheng, Lu Meng-Chun, Jeng Long-Bin, Hsiao Chieh-Lun, Yueh Te-Cheng, Fu Chun-Kai, Li Hsin-Ting, Yen Shiou-Ting, Lin Chia-Wen, Wu Cin-Wun, Pang Su-Yi, Bau Da-Tian, and Tsai Fuu-Jen

Subjects
Drinking, Gastric cancer, Genotype, MMP1, Polymorphism, Smoking, Taiwan, Medicine
Abstract

Expression of matrix metalloproteinase-1 (MMP1), an interstitial collagenase regulating the extracellular matrix, plays a major role in carcinogenesis of gastric cancer, a leading cause of death worldwide. In literature, the single-nucleotide polymorphism (SNP) promoter -1607 1G/2G (rs1799750) at the MMP1 gene promoter has been reported to alter its own transcription level. While the importance’s of the genotype of MMP1 promoter -1607 has not yet been studied in gastric cancer in Taiwan, our aim was to investigate MMP1 promoter -1607 genotypes and gastric cancer (GC) susceptibility in central Taiwan population. In the current hospital-based case-control study, the contribution of MMP1 promoter -1607 genotypes to GC risk was investigated among 121 GC patients and 363 gender- and age-matched healthy controls recruited and genotyped by the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology. We found that the genotypic and allelic frequencies were not differentially distributed between GC patient and control groups. The variant 1G containing genotypes have interactions with cigarrete smoking behaviors and Helicobacter pylori infection status, but not alcoholism on GC susceptibility determination. Our findings suggest that the variant 1G allele on MMP1 promoter -1607 may contribute to GC carcinogenesis and may be useful for GC early detection and prevention when combined with cigarrete smoking behaviors and Helicobacter pylori infection status.

Published
2017
Full Text
View/download PDF

90. Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage

Author

Liu, Chun-Jen, Lee, Po-Huang, Lin, Deng-Yn, Wu, Cheng-Chung, Jeng, Long-Bin, Lin, Pin-Wen, Mok, King-Tong, Lee, Wei-Chen, Yeh, Hong-Zen, Ho, Ming-Chih, Yang, Sheng-Shun, Lee, Ching-Chih, Yu, Ming-Chin, Hu, Rey-Heng, Peng, Cheng-Yuan, Lai, Kuan-Lang, Chang, Stanley Shi-Chung, and Chen, Pei-Jer

Published
2009
Full Text
View/download PDF

97. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

Author

Ding, Qingqing, Chang, Chun-Ju, Xie, Xiaoming, Xia, Weiya, Yang, Jer-Yen, Wang, Shao-Chun, Wang, Yan, Xia, Jiahong, Chen, Libo, Cai, Changchung, Li, Huabin, Yen, Chia-Jui, Kuo, Hsu-Ping, Lee, Dung-Fang, Lang, Jingyu, Huo, Longfei, Cheng, Xiaoyun, Chen, Yun-Ju, Li, Chia-Wei, Jeng, Long-Bin, Hsu, Jennifer L., Li, Long-Yuan, Tan, Alai, Curley, Steven A., Ellis, Lee M., DuBois, Raymond N., and Hung, Mien-Chie

Subjects
Development and progression, Genetic aspects, Research, Cancer cells -- Genetic aspects, Colorectal cancer -- Development and progression, Liver -- Genetic aspects, Cancer metastasis -- Development and progression -- Genetic aspects, Gene expression -- Research, Metastasis -- Development and progression -- Genetic aspects
Abstract

Colorectal cancer is the second leading cause of death from cancer in the United States. Metastases in the liver, the most common metastatic site for colorectal cancer, are found in [...]

Published
2011
Full Text
View/download PDF

99. Pyogenic liver abscess in the elderly: clinical features, outcomes and prognostic factors

Author

Chen, Shiuan-Chih, Lee, Yuan-Ti, Yen, Chi-Hua, Lai, Kuang-Chi, Jeng, Long-Bin, Lin, Ding-Bang, Wang, Po-Hui, Chen, Chun-Chieh, Lee, Meng-Chih, and Bell, William R.

Subjects
Liver diseases -- Demographic aspects, Liver diseases -- Care and treatment, Aged patients -- Care and treatment, Health, Psychology and mental health, Seniors, Social sciences
Published
2009

Catalog

Books, media, physical & digital resources
See catalog results