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A series of new sinomenine derivatives were designed, synthesized, and evaluated in tumor inhibitory activity, such as human triple negative breast cancer cell line (MDA-MB-231), glioma cell line (A172), human lung cancer cell line (A549), human colon cancer cell line (HCT-8). The modifications were carried out on rings A and C of the sinomenine by esterificating on phenolic hydroxyl with good yields. The highlight of this work was that the synthetic procedures were concise and sinomenine derivatives demonstrated promising antitumor activities.

Background/Aims: Excess dietary salt is a critical risk factor of salt-sensitive hypertension. Glucagon-like peptide-1 (GLP-1) , a gut incretin hormone, conferring benefits for blood pressure by natriuresis and diuresis. We implemented a randomized trial to verify the effect of altered salt intake on serum GLP-1 level in human beings. Methods: The 38 subjects were recruited from a rural community of Northern China. All subjects were sequentially maintained a baseline diet period for 3 days, a low-salt diet period for 7 days (3.0g/day of NaCl) , and a high-salt diet period for additional 7 days (18.0g/day of NaCl). Results: Serum GLP-1 level increased significantly with the change from the baseline period to the low-salt diet period and decreased with the change from the low-salt to high-salt diet in normotensive salt-sensitive (SS) but not salt-resistant (SR) individuals. There was a significant inverse correlation between the serum GLP-1 level and the MAP in SS subjects. Inverse correlation between the serum GLP-1 level and 24-h urinary sodium excretion was also found among different dietary interventions in SS subjects. Conclusions: Our study indicates that variations in dietary salt intake affect the serum GLP-1 level in normotensive salt-sensitive Chinese adults.

Objective:Cyclooxygenase (COX)-2, inducible isoform of a major rate-limiting enzyme, contributes to the regulation of prostaglandins, which associates with injury, inflammation and proliferation. We sought to examine the associations of serum COX-2 levels and its genetic variants with salt sensitivi

The solid–liquid equilibria in quaternary system Na2B4O7–Na2SO4–NaBr–H2O and its ternary subsystem Na2B4O7–NaBr–H2O at 323 K were studied with the method of isothermal solution saturation. The solubilities of salts and equilibrium solid phases in the two systems were determined. The solubility diagram of the ternary system has one invariant point, two univariant curves and two fields of crystallization [Na2B4O7·10H2O and NaBr·2H2O]. The solubility diagram of the quaternary system has one invariant point, three univariant curves, and three crystallization fields, where the equilibrium solids are Na2B4O7·10H2O, Na2SO4 and NaBr·2H2O, respectively. According to our experimental data, the solubility of NaBr·2H2O is highest among the three salts, and that of Na2B4O7·10H2O is lowest. Therefore, the field of crystallization of Na2B4O7·10H2O(s) in ternary or quaternary system is larger than others. The addition of sodium bromide leads to rapid decrease of the solubility of Na2B4O7·10H2O(s).

Phase equilibria of the quaternary NaCl–NaBr–Na2SO4–H2O system at 323 K were studied by the isothermal dissolution equilibrium method. The solubilities of salts and densities of saturated solutions were determined. Solid solutions [Na(Cl, Br)] were found in the experiments. The phase diagram of the quaternary system has no invariant point, but has one univariant curve at the boundary of Na(Cl, Br) and Na2SO4 crystallization fields. The experimental results show that an increase of the NaBr concentration is accompanied by an obvious increase of the solution density and the decrease of the solubilities of NaCl and Na2SO4.

Because of the large diameter’s big volume, heavy weight, high thermal capacity and bad measurement environment, the workpiece’s diameter can only be detected in the processing locale. Though the rolling-wheel method can realize the large diameter online measurement, it can not achieve the diameter high precision measurement influenced by rolling-wheel skidding, compression deformation and temperature distribution. Focusing on the above problem, a new multi function rolling-wheel large diameter measurement system is designed. The designed system mainly researches the main error resource’s distinguish and amendment methods, such as the round grating graduator error, rolling-wheel shape error, rolling-wheel compression deformation, skidding of rolling-wheel to measured axis workpiece and its non-uniform temperature etc. The system can obtain the measured axis’s diameter and roundness real time while getting the needed information of error amendment by integrating multi opto-electronic switch, round grating, reference grating, micro-displacement sensor, temperature sensor etc. The system can realize diameter measurement extended uncertainty 5Dμm(D:1m～10m) and roundness measurement extended uncertainty 1.5Dμm.

Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J–M (1–4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated by spectroscopic methods and were subsequently confirmed by comparing with data of known compounds. The absolute configuration of the bicyclo[3.3.1]nonane-2,4,9-trione core was defined by the experimental and calculated electronic circular dichroism (ECD) spectra. The evaluation of their hepatoprotective activities against paracetamol-induced HepG2 cell damage showed that compounds 2 and 4 exhibited significant hepatoprotection at 10 μM.

Polygon ranging-based space coordinate measurement network, which has high measurement accuracy and simple structure, is suitable for large-scale metrology. In practice, the measurement network should be constructed flexibly according to coverage and shape and measurement accuracy of different measurand. Based on this, a universal analysis model of structural optimization is proposed. The relation between structural parameters (amount and layout of measurement base stations) and distribution of measurement accuracy of the measurement network are researched on the model. The model can provide theoretic basis for optimized and flexible design of the measurement network. A case is used to illustrate this model. The results verify that the module can be used for scientifically establishing measurement system of ultra-large size, and also preliminarily simulating and optimally designing the being adopted measurement network and measurement method for meeting requirements of size and measurement accuracy (including global and local accuracy) of different work pieces.

Wireless Sensor Networks (WSN) has been increasingly used in various fields of modern production and life, such as industrial control and environmental monitoring. However, there is no effective and universal algorithm at present for optimizing the deployment of WSN nodes in buildings. The main reason is the complex environment of the monitoring region which brings about the difficulty in determining the attenuation of wireless signal. The relationship between the Received Signal Strength Indicator (RSSI) and Packet Error Rate (PER) are discovered by the experimental method, then the corresponding mathematical model is also established by the experimental data. Based on different PER value, one method for optimizing the deployment of nodes in buildings is proposed by the RSSI value of the sensor node. This method can use fewer sensor nodes to cover the required monitoring region, which has the advantage of low-cost network construction, easy maneuverability and good versatility and et al. Finally, the deployment method of sensor nodes and the deployment example of temperature and humidity monitoring system are given in the paper.

In this paper, a new type of ship lights controller is presented, which is based on AVR microcontroller, and adopts modular design with isolation between electricity and electronics. The control panel uses LED lattice to indicate the actual layout of the lights and vary lights brightness. Electrical current detection device is used to monitor ship lights. So that the alarm rings when any of the lights is burnt out. The software is developed based on Windows environment, with graphical interface, so that it is easy to use. The proposed controller can be redeveloped to adapt to different configuration of different ship lights.

IC- (Integrated circuits) sorting machine is a kind of special equipment used for testing, classifying and grading IC chips, which is of significances in IC industry. Traditionally, IC- sorting machine is controlled by industry personal computer (IPC), which bears disadvantages such as large size and high cost. By contrast, the control system for IC-sorting machines presented in this paper is based on micro control unit (MCU), which is of relatively high reliability as well as high stability but low cost. First, we gave an outline of the configuration and operation principle of the sorting machine. Second, the input and output (I/O) signals that should be controlled were classified. Last but not least, the control strategy was presented both from the hardware side and the software side. In terms of the hardware design, touch screen was adopted as the human interface device (HID) for the sake of convenience, and isolated power module as well as optical isolated module were applied to improve the anti- electro magnetic interference (EMI) performance; In terms of software design, mechanisms such as multi-task by-turn and timer interrupt delay were adopted to improve the operation efficiency.

Location information is the most important for wireless sensor network (WSN). Due to the limitation of energy, cost and influence of environment, range-free localization schemes are more suitable for WSN despite of their low localization accuracy. Two methods, which are improved grids SCAN and multiple locating and averaging scheme, are presented to improve localization accuracy of range-free localization schemes and performed through performance evaluation based on ROCRSSI (Ring Overlapping based on Comparison of Received Signal Strength Indicator). By simulation it is concluded that ROCRSSI applying both methods can get better localization performances.

We-the-media (aka wedia) is a concept where the users of social networking sites, such as Facebook, turn into the broadcasters. This study used the popular application Bitstrips as the experiment tool. Facebook was used as the Wedia platform for publishing designed comics, then used the three elements of Goffman’s dramaturgy model—role, scene and dialog—to analyze 265 comics created by 3 researchers and observe the audience’s responses within 9 months. The results showed that people want to see a good story with positive dialogue, and prefer scene is school more than work. As all these elements are controllable, Wedia communication has the potential for more applications. We also found that including the elements of news, gambling and gift-giving tended to trigger greater response. Furthermore, We suggesting that such embedding of product information in web episodes (webisodes) with caricature could be a successful marketing strategy.

An environment-friendly method is developed to fabricate close-packed Au nanoparticle (AuNP) monolayers with sub-10 nm interparticle spacing simply by covering n-butanol on the surface of an Au aqueous colloid. The close-packed nanostructure can further transform into two-dimensional (2D) aggregates with different aggregation degrees upon aging for several days. This structural evolution process was disclosed by transition electron microscopy (TEM) and UV-vis spectroscopy and its influence on the ensemble optical properties was further demonstrated by surface-enhanced Raman scattering (SERS). It was revealed that creating sub-10 nm interparticle spacing and particle dimers are highly desirable for engendering strong SERS activity under a 632.8 nm excitation. Further aging the film leads to the formation of larger aggregates, which moves the surface plasmon resonance of the aggregates gradually 'off-resonance' from the 632.8 nm excitation line and costs some numbers of sub-10 nm interparticle spacings. The two parameters together decrease the SERS activity of the close-packed AuNP monolayers. The present strategy thus provides an easy way to finely tune the SERS properties of thin nanoparticle films and other ensemble properties, which can easily be realized by creating sub-10 interparticle spacing, controlling the particle aggregation degree and by adopting suitable particle sizes and shapes.