76 results on '"Jiachen Du"'
Search Results
52. Open-Circuit Fault-Tolerant Control of Five-Phase PMSM Drives
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Wentao Huang, Minjie Huang, Liyan Luo, Jiachen Du, and Xiaofeng Zhu
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- 2022
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53. A Question Answering Approach to Emotion Cause Extraction.
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Lin Gui 0003, Jiannan Hu, Yulan He 0001, Ruifeng Xu 0001, Qin Lu 0001, and Jiachen Du
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- 2017
54. Mechanical properties analysis of medical endodontic instruments based on parameterization
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Xiulin Hu, Gongwei Zhao, Jiachen Du, and Nanhai Ye
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Biomaterials ,Titanium ,Mechanics of Materials ,Finite Element Analysis ,Materials Testing ,Biomedical Engineering ,Computer Simulation ,Equipment Design ,Stress, Mechanical ,Pliability ,Root Canal Preparation ,Dental Alloys - Abstract
To study the relationship between structural parameters and mechanical properties of endodontic instruments, the T02004B25 nickel-titanium endodontic instrument was selected for bending and torsion tests and finite element simulation analysis, which demonstrated the feasibility of simulation analysis method. Then based on the idea of parametric design, the models of the endodontic instruments with different structural parameters (cross-section, pitch, taper) were established, and the bending-torsion performance simulation analysis was completed. The results showed that the mechanical properties of endodontic instruments with different structural parameters are different. It is necessary to find the optimal parameters for different structure parameters of endodontic instruments to maximize their service life.
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- 2022
55. Reproducibility of volume and asymmetry measurements of hippocampus, amygdala, and entorhinal cortex on traveling volunteers: a multisite MP2RAGE prospective study
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Jianhui Zhong, Ting Gong, Hongjian He, Qiqi Tong, Peipeng Liang, Jiachen Du, Tianyi Qian, Kuncheng Li, and Yi Sun
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Adult ,Male ,Hippocampus ,Amygdala ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Reference Values ,medicine ,Entorhinal Cortex ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,030304 developmental biology ,0303 health sciences ,Reproducibility ,Radiological and Ultrasound Technology ,business.industry ,Reproducibility of Results ,General Medicine ,Entorhinal cortex ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Female ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Background Multisite studies can considerably increase the pool of normally aging individuals with neurodegenerative disorders and thereby expedite the associated research. Understanding the reproducibility of the parameters of related brain structures—including the hippocampus, amygdala, and entorhinal cortex—in multisite studies is crucial in determining the impact of healthy aging or neurodegenerative diseases. Purpose To estimate the reproducibility of the fascinating structures by automatic (FreeSurfer) and manual segmentation methods in a well-controlled multisite dataset. Material and Methods Three traveling individuals were scanned at 10 sites, which were equipped with the same equipment (3T Prisma Siemens). They used the same scan protocol (two inversion-contrast magnetization-prepared rapid gradient echo sequences) and operators. Validity coefficients (intraclass correlations coefficient [ICC]) and spatial overlap measures (Dice Similarity Coefficient [DSC]) were used to estimate the reproducibility of multisite data. Results ICC and DSC values varied substantially among structures and segmentation methods, and values of manual tracing were relatively higher than the automated method. ICC and DSC values of structural parameters were greater than 0.80 and 0.60 across sites, as determined by manual tracing. Low reproducibility was observed in the amygdala parameters by automatic segmentation method (ICC = 0.349–0.529, DSC = 0.380–0.873). However, ICC and DSC scores of the hippocampus were higher than 0.60 and 0.65 by two segmentation methods. Conclusion This study suggests that a well-controlled multisite study could provide a reliable MRI dataset. Manual tracing of volume assessments is recommended for low reproducibility structures that require high levels of precision in multisite studies.
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- 2020
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56. Torque Ripple Suppression-Based Fault-Tolerant Model Predictive Current Control of Five-Phase PMSM Drives with Open-Circuit Faults
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Jiachen Du, Liyan Luo, and Wentao Huang
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- 2022
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57. Target-adaptive graph for cross-target stance detection
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Ruifeng Xu, Bin Liang, Min Yang, Yonghao Fu, Jiachen Du, Lin Gui, and Yulan He
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Boosting (machine learning) ,Dependency (UML) ,Computer science ,business.industry ,Sentiment analysis ,Context (language use) ,02 engineering and technology ,Pragmatics ,computer.software_genre ,QA76 ,0202 electrical engineering, electronic engineering, information engineering ,Graph (abstract data type) ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,computer ,Word (computer architecture) ,Natural language processing ,Sentence - Abstract
Target plays an essential role in stance detection of an opinionated review/claim, since the stance expressed in the text often depends on the target. In practice, we need to deal with targets unseen in the annotated training data. As such, detecting stance for an unknown or unseen target is an important research problem. This paper presents a novel approach that automatically identifies and adapts the target-dependent and target-independent roles that a word plays with respect to a specific target in stance expressions, so as to achieve cross-target stance detection. More concretely, we explore a novel solution of constructing heterogeneous target-adaptive pragmatics dependency graphs (TPDG) for each sentence towards a given target. An in-target graph is constructed to produce inherent pragmatics dependencies of words for a distinct target. In addition, another cross-target graph is constructed to develop the versatility of words across all targets for boosting the learning of dominant word-level stance expressions available to an unknown target. A novel graph-aware model with interactive Graphical Convolutional Network (GCN) blocks is developed to derive the target-adaptive graph representation of the context for stance detection. The experimental results on a number of benchmark datasets show that our proposed model outperforms state-of-the-art methods in cross-target stance detection.\ud \ud
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- 2021
58. ‘Sultanina’ leaves increase their trehalose content in response to grapevine brown leaf spot infection by regulating the pentose and glucuronate interchange pathway
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Chuan Zhang, Haixia Zhong, Haoyu Chen, Nuerziya Yalimaimaiti, Ju Liang, Jiachen Duan, Yameng Yang, Songlin Zhang, Vivek Yadav, Xiaoming Zhou, Xinyu Wu, Fuchun Zhang, and Jingzhe Hao
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Grapevine brown leaf spot ,Transcriptome ,Trehalose content ,Pentose and glucuronate interchange pathway ,Response mechanism ,Plant ecology ,QK900-989 - Abstract
Since the first discovery of grapevine brown leaf spot disease in Turpan, Xinjiang, China, in 2007, it has been a common occurrence in grapevine-growing regions. Grapevine brown leaf spot seriously decreases fruit yield and has become one of the most important leaf diseases in the Turpan region. However, thus far, there have been no reports on the evaluation of grapevine germplasm resources for resistance to brown leaf spot disease. In addition, the response mechanism of grapevine leaves to brown leaf spot infection has not been revealed. To better understand the resistance of grapevine germplasm resources to brown leaf spot disease, we first evaluated resistance in grapevine varieties. On this basis, the most susceptible variety ‘Sultanina’ was selected as the experimental material for this study. Transcriptome analysis and carbohydrate content analysis were performed on ‘Sultanina’ leaves with different levels of disease susceptibility. As the severity of the disease increased, the content of fructose gradually decreased, while the content of trehalose gradually increased. Transcriptome data revealed that differentially expressed genes were enriched in the pentose and glucuronate interchange pathway. These results suggest that the sugar trehalose may play an important role in the response of ‘Sultanina’ leaves to brown leaf spot infection. In addition, the pentose and glucuronate interchange pathway may be involved in the response mechanism of brown leaf spot disease. Our work provides new insights into the mechanism of the ‘Sultanina’ leaf response to brown leaf spot infection.
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- 2024
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59. All‐In‐One Integrated Multifunctional Broadband Metasurface for Analogue Signal Processing, Polarization Conversion, Beam Manipulation, and Near‐Field Sensing
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Baiyang Liu, Jiachen Du, Xiaonan Jiang, Yin Li, Sai‐Wai Wong, Qiang Cheng, Tie Jun Cui, and Qingfeng Zhang
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Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2022
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60. Exploring the Relationship between Gray and White Matter in Healthy Adults: A Hybrid Research of Cortical Reconstruction and Tractography
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Hongjian He, Qianqian Li, Yongxiang Zhao, Jiachen Du, Kuncheng Li, Jie Lu, and Peipeng Liang
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Adult ,Male ,Article Subject ,Biology ,Gray (unit) ,General Biochemistry, Genetics and Molecular Biology ,030218 nuclear medicine & medical imaging ,Correlation ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Fractional anisotropy ,medicine ,Humans ,Gray Matter ,General Immunology and Microbiology ,General Medicine ,Human brain ,White Matter ,medicine.anatomical_structure ,Diffusion Tensor Imaging ,Medicine ,Female ,Neuroscience ,030217 neurology & neurosurgery ,Tractography ,Diffusion MRI ,Research Article - Abstract
The gray matter (GM) and white matter (WM) are structurally and functionally related in the human brain. Among the numerous neuroimaging studies, yet only a few have investigated these two structures in the same sample. So, there is limited and inconsistent information about how they are correlated in the brain of healthy adults. In this study, we combined cortical reconstruction with diffusion spectrum imaging (DSI) tractography to investigate the relationship between cortical morphology and microstructural properties of major WM tracts in 163 healthy young adults. The results showed that cortical thickness (CTh) was positively correlated with the coherent tract-wise fractional anisotropy (FA) value, and the correlation was stronger in the dorsal areas than in the ventral areas. For other diffusion parameters, CTh was positively correlated with axial diffusivity (AD) of coherent fibers in the frontal areas and negatively correlated with radial diffusivity (RD) of coherent fibers in the dorsal areas. These findings suggest that the correlation between GM and WM is inhomogeneity and could be interpreted with different mechanisms in different brain regions. We hope our research could provide new insights into the studies of diseases in which the GM and WM are both affected.
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- 2021
61. Jointly Learning Aspect-Focused and Inter-Aspect Relations with Graph Convolutional Networks for Aspect Sentiment Analysis
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Jiachen Du, Ruifeng Xu, Rongdi Yin, Bin Liang, and Lin Gui
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Theoretical computer science ,Computer science ,Sentiment analysis ,02 engineering and technology ,Graph ,GeneralLiterature_MISCELLANEOUS ,QA76 ,Dependency graph ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Embedding ,Graph (abstract data type) ,020201 artificial intelligence & image processing ,Dependency tree ,Sentence - Abstract
In this paper, we explore a novel solution of constructing a heterogeneous graph for each instance by leveraging aspect-focused and inter-aspect contextual dependencies for the specificaspect. Based on it, we propose a novel graph-aware model with Interactive Graph Convolutional Networks (InterGCN) for aspect sentiment analysis. Specifically, an ordinary dependencygraph is first constructed for each sentence over the dependency tree. Then we refine the graph byconsidering the syntactical dependencies between contextual words and aspect-specific words toderive the aspect-focused graph. Subsequently, the aspect-focused graph and the correspondingembedding matrix are fed into the aspect-focused GCN to capture the key aspect and contextualwords. Besides, to interactively extract the dependencies between the aspect words and otheraspects, an inter-aspect GCN is adopted to model the representations learned by aspect-focusedGCN based on the inter-aspect graph. Hence, the model can be aware of the significant contextual and aspect words when interactively learning the sentiment features for a specific aspect.Experimental results on four benchmark datasets illustrate that our proposed model outperformsstate-of-the-art methods and substantially boosts the performance in comparison with BERT.
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- 2020
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62. Aspect-Invariant Sentiment Feature Learning: Adversarial Multi-task Learning for Aspect-based Sentiment Analysi
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Bin Liang, Rongdi Yin, Lin Gui, Jiachen Du, Yulan He, and Ruifeng Xu
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Sentiment analysis ,Machine leanring ,GAN - Abstract
In most previous studies, information about aspects in sentences is considered important for the Aspect-based Sentiment Analysis (ABSA task and therefore various attention mechanisms have been explored to leverage interactions between aspects and context. However, some sentiment expressions carry the same polarity regardless of the aspects they are associated with. In such cases, it is not necessary to incorporate aspect information for ABSA. In fact, in our experiments, we find that blindly leveraging interactions between aspects and context as features may introduce noise when analyzing those aspect-invariant sentiment expressions, especially when facing with limited aspect-related annotated data. Hence, in this paper, we propose an Adversarial Multi-task Learning Framework to identify the aspect-invariant/dependent sentiment expressions automatically without requiring extra annotations. In addition, we use a gating mechanism to control the contribution of representations derived from aspect-invariant and aspect-dependent hidden states when generating the final contextual sentiment representations for the given aspect. This essentially allows the exploitation of aspect-invariant sentiment features for better ABSA results. Experimental results on two benchmark datasets show that extending existing neural models using our proposed framework achieves superior performance. In addition, the aspect-invariant data extracted by our framework can be considered as pivot features for better transfer learning of the ABSA models on unseen aspects. 
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- 2020
63. Commonsense Knowledge Enhanced Memory Network for Stance Classification
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Xuan Wang, Erik Cambria, Lin Gui, Jiachen Du, Yunqing Xia, and Ruifeng Xu
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Relation (database) ,Commonsense knowledge ,Computer Networks and Communications ,business.industry ,Computer science ,Knowledge engineering ,Sentiment analysis ,02 engineering and technology ,Representation (arts) ,computer.software_genre ,SemEval ,Memory module ,Artificial Intelligence ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,Affective computing ,computer ,Natural language processing - Abstract
Stance classification aims at identifying, in the text, the attitude toward the given targets as favorable, negative, or unrelated. In existing models for stance classification, only textual representation is leveraged, while commonsense knowledge is ignored. In order to better incorporate commonsense knowledge into stance classification, we propose a novel model named commonsense knowledge enhanced memory network, which jointly represents textual and commonsense knowledge representation of given target and text. The textual memory module in our model treats the textual representation as memory vectors, and uses attention mechanism to embody the important parts. For commonsense knowledge memory module, we jointly leverage the entity and relation embeddings learned by TransE model to take full advantage of constraints of the knowledge graph. Experimental results on the SemEval dataset show that the combination of the commonsense knowledge memory and textual memory can improve stance classification.
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- 2020
64. Convolution-Based Neural Attention With Applications to Sentiment Classification
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Xuan Wang, Ruifeng Xu, Lin Gui, Jiachen Du, and Yulan He
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General Computer Science ,02 engineering and technology ,QA76 ,Convolution ,Mathematical explanation ,sentiment classification ,convolutional neural networks ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,QA ,Network architecture ,Quantitative Biology::Neurons and Cognition ,business.industry ,Mechanism (biology) ,Natural language processing ,General Engineering ,020206 networking & telecommunications ,Attention model ,Recurrent neural network ,Salient ,neural attention model ,020201 artificial intelligence & image processing ,Artificial intelligence ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,business ,lcsh:TK1-9971 ,Sentence - Abstract
Neural attention mechanism has achieved many successes in various tasks in natural language processing. However, existing neural attention models based on a densely connected network are loosely related to the attention mechanism found in psychology and neuroscience. Motivated by the finding in neuroscience that human possesses the template-searching attention mechanism, we propose to use convolution operation to simulate attentions and give a mathematical explanation of our neural attention model. We then introduce a new network architecture, which combines a recurrent neural network with our convolution-based attention model and further stacks an attention-based neural model to build a hierarchical sentiment classification model. The experimental results show that our proposed models can capture salient parts of the text to improve the performance of sentiment classification at both the sentence level and the document level.
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- 2019
65. sj-pdf-1-acr-10.1177_0284185120963919 - Supplemental material for Reproducibility of volume and asymmetry measurements of hippocampus, amygdala, and entorhinal cortex on traveling volunteers: a multisite MP2RAGE prospective study
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Jiachen Du, Peipeng Liang, Hongjian He, Qiqi Tong, Gong, Ting, Tianyi Qian, Sun, Yi, Jianhui Zhong, and Kuncheng Li
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110320 Radiology and Organ Imaging ,FOS: Clinical medicine - Abstract
Supplemental material, sj-pdf-1-acr-10.1177_0284185120963919 for Reproducibility of volume and asymmetry measurements of hippocampus, amygdala, and entorhinal cortex on traveling volunteers: a multisite MP2RAGE prospective study by Jiachen Du, Peipeng Liang, Hongjian He, Qiqi Tong, Ting Gong, Tianyi Qian, Yi Sun, Jianhui Zhong and Kuncheng Li in Acta Radiologica
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- 2020
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66. A Knowledge Regularized Hierarchical Approach for Emotion Cause Analysis
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Hongyu Yan, Min Yang, Chuang Fan, Ruifeng Xu, Jiachen Du, Mao Ruibin, Lidong Bing, and Lin Gui
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Artificial neural network ,business.industry ,Computer science ,Sentiment analysis ,BF ,Context (language use) ,02 engineering and technology ,010502 geochemistry & geophysics ,computer.software_genre ,Lexicon ,01 natural sciences ,Focus (linguistics) ,Variety (cybernetics) ,P1 ,Common knowledge ,0202 electrical engineering, electronic engineering, information engineering ,Key (cryptography) ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,QA ,computer ,Natural language processing ,0105 earth and related environmental sciences - Abstract
Emotion cause analysis, which aims to identify the reasons behind emotions, is a key topicin sentiment analysis. A variety of neuralnetwork models have been proposed recently,however, these previous models mostly focuson the learning architecture with local textual information, ignoring the discourse andprior knowledge, which play crucial roles inhuman text comprehension. In this paper,we propose a new method to extract emotion cause with a hierarchical neural modeland knowledge-based regularizations, whichaims to incorporate discourse context information and restrain the parameters by sentiment lexicon and common knowledge. Theexperimental results demonstrate that our proposed method achieves the state-of-the-art performance on two public datasets in differentlanguages (Chinese and English), outperforming a number of competitive baselines by atleast 2.08% in F-measure.
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- 2019
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67. Context-aware Embedding for Targeted Aspect-based Sentiment Analysis
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Hejiao Huang, Bin Liang, Binyang Li, Ruifeng Xu, and Jiachen Du
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FOS: Computer and information sciences ,050101 languages & linguistics ,Computer Science - Computation and Language ,business.industry ,Computer science ,05 social sciences ,Sentiment analysis ,Context (language use) ,02 engineering and technology ,Machine learning ,computer.software_genre ,Task (project management) ,Computer Science - Information Retrieval ,0202 electrical engineering, electronic engineering, information engineering ,Benchmark (computing) ,Embedding ,020201 artificial intelligence & image processing ,0501 psychology and cognitive sciences ,Artificial intelligence ,business ,computer ,Computation and Language (cs.CL) ,Information Retrieval (cs.IR) - Abstract
Attention-based neural models were employed to detect the different aspects and sentiment polarities of the same target in targeted aspect-based sentiment analysis (TABSA). However, existing methods do not specifically pre-train reasonable embeddings for targets and aspects in TABSA. This may result in targets or aspects having the same vector representations in different contexts and losing the context-dependent information. To address this problem, we propose a novel method to refine the embeddings of targets and aspects. Such pivotal embedding refinement utilizes a sparse coefficient vector to adjust the embeddings of target and aspect from the context. Hence the embeddings of targets and aspects can be refined from the highly correlative words instead of using context-independent or randomly initialized vectors. Experiment results on two benchmark datasets show that our approach yields the state-of-the-art performance in TABSA task.
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- 2019
68. A Uniplanar Vivaldi Antenna
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Xia Fen, Amir Khurrum Rasahid, Qingfeng Zhang, and Jiachen Du
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Fabrication ,Materials science ,business.industry ,Coplanar waveguide ,Bandwidth (signal processing) ,Ultra-wideband ,020206 networking & telecommunications ,02 engineering and technology ,law.invention ,Radiation pattern ,Optics ,law ,0202 electrical engineering, electronic engineering, information engineering ,Reflection coefficient ,Wideband ,business ,Vivaldi antenna - Abstract
A very wideband uniplanar quasi-Vivaldi antenna is presented. Based on its easy fabrication, low cost, and wideband high gain performance, it appears suitable for imaging and other useful applications. It consists of a coplanar waveguide feed, and a pair Vivaldi patches. It exhibits a 10 dB reflection coefficient bandwidth of 1.9 GHz - 20 GHz. Its radiation pattern is also stable over a wide range of frequencies.
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- 2019
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69. Dynamic Coal-Rock Interface Identification Based on Infrared Thermal Image Characteristics
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Zhishen Liangl, Jiachen Du, Qing Shao, Xiaoxuan Huangl, Xu Li, Alla ALdeen Housein, Haijian Wangl, and Xuemei Zhaol
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Fuzzy entropy ,Infrared ,business.industry ,Computer science ,Thermal ,Fuzzy set ,Feature extraction ,Entropy (information theory) ,Coal ,Pattern recognition ,Artificial intelligence ,business ,complex mixtures - Abstract
In this study, a new method was proposed to identify the coal-rock interface based on infrared thermal image characteristics during cutting process, which overcomes the problem of low identification accuracy. The cutting signals change significantly with the coal-rock proportion, thus, seven coal-rock mixture test specimens with different proportions were poured. Then, the infrared thermal images of peak were tested while cutting coal-rock specimens with different proportions. Furthermore, by analyzing the flash temperature characteristics of picks, a temperature characteristic database of peaks while cutting different coal-rock specimens was built. Finally, a dynamic recognition model for coal-rock interface identification was established based on minimum fuzzy entropy. The experimental results show that, the total recognition error was merely 3.24%, which proved that the proposed method improved the identification accuracy effectively and provided the theoretical foundation and technical premise to realize automatic and intelligent mining.
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- 2019
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70. Characterization of Trap States in AlGaN/GaN MIS-High-Electron-Mobility Transistors under Semi-on-State Stress
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Ye Liang, Jiachen Duan, Ping Zhang, Kain Lu Low, Jie Zhang, and Wen Liu
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AlGaN/GaN MIS-HEMT ,current collapse ,trap states ,energy level ,trap density ,Chemistry ,QD1-999 - Abstract
Devices under semi-on-state stress often suffer from more severe current collapse than when they are in the off-state, which causes an increase in dynamic on-resistance. Therefore, characterization of the trap states is necessary. In this study, temperature-dependent transient recovery current analysis determined a trap energy level of 0.08 eV under semi-on-state stress, implying that interface traps are responsible for current collapse. Multi-frequency capacitance–voltage (C-V) testing was performed on the MIS diode, calculating that interface trap density is in the range of 1.37×1013 to 6.07×1012cm−2eV−1 from EC−ET=0.29 eV to 0.45 eV.
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- 2024
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71. A question answering approach for emotion cause extraction
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Ruifeng Xu, Lin Gui, Yulan He, Jiannan Hu, Jiachen Du, and Qin Lu
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Computer science ,business.industry ,Emotion classification ,Context (language use) ,02 engineering and technology ,computer.software_genre ,Convolutional neural network ,Task (project management) ,Identification (information) ,Reading comprehension ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Question answering ,020201 artificial intelligence & image processing ,Artificial intelligence ,business ,computer ,Word (computer architecture) ,Natural language processing - Abstract
Emotion cause extraction aims to identify the reasons behind a certain emotion expressed in text. It is a much more difficult task compared to emotion classification. Inspired by recent advances in using deep memory networks for question answering (QA), we propose a new approach which considers emotion cause identification as a reading comprehension task in QA. Inspired by convolutional neural networks, we propose a new mechanism to store relevant context in different memory slots to model context information. Our proposed approach can extract both word level sequence features and lexical features. Performance evaluation shows that our method achieves the state-of-the-art performance on a recently released emotion cause dataset, outperforming a number of competitive baselines by at least 3.01% in F-measure.
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- 2017
72. Experimental realization of quantum walks near synthetic horizons on photonic lattices
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Runqiu He, Yule Zhao, Chong Sheng, Jiachen Duan, Ying Wei, Changwei Sun, Liangliang Lu, Yan-Xiao Gong, Shining Zhu, and Hui Liu
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Physics ,QC1-999 - Abstract
Entanglement plays crucial roles in quantum optics, providing a prerequisite for these recent unprecedented leaps. Nevertheless, the study of quantum entanglement under the influence of relativity, an important ingredient of quantum optics, still needs to be explored. In parallel, integrated photonic chips, particularly those with the aid of transformation optics, have simulated various relativity phenomena including gravitational lensing and Unruh radiation. However, thus far, studying relativistic quantum optics on this type of platform has not yet occurred. Here, we propose and experimentally realize quantum walks of entangled photons near an emulated Rindler horizon. Remarkably, we find that quantum interference near the synthetic horizon leads to a counterintuitive phenomenon of optical escape. Our study paves the way to a tabletop platform for studying quantum phenomena in various relativistic space-time metrics, and may bring an implication for the test of quantum theory in relativity.
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- 2024
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73. Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells
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Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu, and Mingzhi Zhang
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EZH2 ,NF-κB ,Prostate cancer (PCa) ,SOX9 ,TNFRSF11A (RANK) ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Background Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life. The up-regulation of EZH2 is associated with advanced PCa and poor prognosis, making it a promising therapeutic target. However, the EZH2 inhibitors-based treatment is basically ineffective against PCa, which limits its clinical application. Methods Microarray data (GSE107779) from LNCaP cells treated with either siRNA against EZH2 or a EZH2 inhibitor EPZ6438 was analyzed by Limma R package. Western blot, real-time PCR and luciferase reporter assays were used to determine the EZH2-SOX9-TNFRSF11A axis and the activity of NF-κB signaling in PCa cells. CCK-8 assay was used to determine the viability of PCa cells following various treatments. Results Genetic ablation or pharmacological inhibition of EZH2 leads to feedback activation of NF-κB signaling in PCa cells. EZH2-dependent SOX9 expression regulates the activation of NF-κB signaling. TNFRSF11A, also known as receptor activator of NF-κB (RANK), is a downstream target of SOX9 in PCa cells. SOX9 recognizes two putative SOX9 response elements in the promoter region of TNFRSF11A gene to drive TNFRSF11A expression and downstream NF-κB signaling activation. Suppression of the NF-κB signaling by either TNFRSF11A silencing or BAY11-7082 treatment rendered PCa cells to EZH2 inhibitors. Conclusion Collectively, our finding reveals a EZH2-SOX9-TNFRSF11A axis in the regulation of activity of NF-κB signaling in PCa cells and suggests that a combination of EZH2 inhibitors and BAY11-7082 would be an effective approach for the treatment of PCa patients in the future.
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- 2021
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74. Semaphorin 6D as an independent predictor for better prognosis in clear cell renal cell carcinoma
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Jiachen Duan, Mengyuan Jin, and Baoping Qiao
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Biomarker ,Bioinformation ,Diagnosis ,Tumor suppressor gene ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Clear cell renal cell carcinoma (ccRCC) is the most common type of RCC and is associated with poor survival. However, the mechanisms underlying its development have not been thoroughly investigated. Semaphorin 6D (SEMA6D) is differentially expressed in various cancers, including lung adenocarcinoma and colorectal cancer. However, the role and mechanism of SEMA6D in ccRCC remain unexplored. Materials and methods: We obtained 25 pairs of ccRCC tissue samples and 57 urine samples from patients with ccRCC and 52 urine samples from healthy volunteers. We performed RNA sequencing and compared the results with data from The Cancer Genome Atlas database to identify our gene of interest, SEMA6D. To verify the differential expression of SEMA6D, we used real-time quantitative polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay. Finally, we conducted in vitro proliferation, migration and invasion experiments. Results: SEMA6D expression was significantly lower in ccRCC tissue compared to that in normal tissue. Comparative analysis of our results with data from online databases revealed that the expression level of SEMA6D in ccRCC tissue correlated with the clinical stage and pathological grade of ccRCC. Furthermore, higher SEMA6D expression was associated with improved quality of life of patients with ccRCC. In addition, the diagnostic value of SEMA6D was confirmed using data from two Gene Expression Omnibus ccRCC databases. The results showed that SEMA6D can be used as a predictor for ccRCC diagnosis, with an area under the curve of 0.9642. Conclusion: SEMA6D may serve as a diagnostic and prognostic biomarker for ccRCC.
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- 2022
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75. LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p
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Zhuo Ye, Jiachen Duan, Lihui Wang, Yanli Ji, and Baoping Qiao
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Clear cell renal cell carcinoma ,LncRNA-LET ,miR-373-3p ,Cell cycle ,Cell apoptosis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common renal cell carcinoma subtype with a poor prognosis. LncRNA-LET is a long non-coding RNA (lncRNA) that is down-regulated in ccRCC tissues. However, its role in ccRCC development and progress is unclear. Methods LncRNA-LET expression was detected in ccRCC tissues and ccRCC cells using quantitative real-time PCR. The overexpression and knockdown experiments were performed in ccRCC cells and xenograft mouse model to evaluate role of lncRNA-LET. Cell cycle, apoptosis and JC-1 assays were conducted via flow cytometer. The protein levels were measured through western blot analysis and the interaction between lncRNA-LET and miR-373-3p was identified via luciferase reporter assay. Results LncRNA-LET expression was lower in ccRCC tissues than that in the matched adjacent non-tumor tissues (n = 16). In vitro, lncRNA-LET overexpression induced cell cycle arrest, promoted apoptosis and impaired mitochondrial membrane potential, whereas its knockdown exerted opposite effects. Moreover, we noted that lncRNA-LET may act as a target for oncomiR miR-373-3p. In contrast to lncRNA-LET, miR-373-3p expression was higher in ccRCC tissues. The binding between lncRNA-LET and miR-373-3p was validated. Two downstream targets of miR-373-3p, Dickkopf-1 (DKK1) and tissue inhibitor of metalloproteinase-2 (TIMP2), were positively regulated by lncRNA-LET in ccRCC cells. MiR-373-3p mimics reduced lncRNA-LET-induced up-regulation of DKK1 and TIMP2 levels, and attenuated lncRNA-LET-mediated anti-tumor effects in ccRCC cells. In vivo, lncRNA-LET suppressed the growth of ccRCC xenograft tumors. Conclusion These findings indicate that lncRNA-LET plays a tumor suppressive role in ccRCC by regulating miR-373-3p.
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- 2019
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76. Variational autoregressive decoder for neural response generation
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Lidong Bing, Xuan Wang, Wenjie Li, Ruifeng Xu, Jiachen Du, and Yulan He
- Subjects
Sequence ,Artificial neural network ,Series (mathematics) ,business.industry ,Computer science ,02 engineering and technology ,Latent variable ,010501 environmental sciences ,Machine learning ,computer.software_genre ,01 natural sciences ,Recurrent neural network ,Autoregressive model ,Bag-of-words model ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Artificial intelligence ,business ,computer ,Word (computer architecture) ,0105 earth and related environmental sciences - Abstract
Combining the virtues of probability graphic models and neural networks, Conditional Variational Auto-encoder (CVAE) has shown promising performance in applications such as response generation. However, existing CVAE-based models often generate responses from a single latent variable which may not be sufficient to model high variability in responses. To solve this problem, we propose a novel model that sequentially introduces a series of latent variables to condition the generation of each word in the response sequence. In addition, the approximate posteriors of these latent variables are augmented with a backward Recurrent Neural Network (RNN), which allows the latent variables to capture long-term dependencies of future tokens in generation. To facilitate training, we supplement our model with an auxiliary objective that predicts the subsequent bag of words. Empirical experiments conducted on Opensubtitle and Reddit datasets show that the proposed model leads to significant improvement on both relevance and diversity over state-of-the-art baselines.
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