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68 results on '"Jiménez Vacas, Juan M."'

51. Potential therapeutic role of somatostatin and cortistatin in prostate cancer

Author

Gomez, Jesus Perez, primary, Sáez-Mart, Prudencio, additional, Jiménez-Vacas, Juan M., additional, Herrero-Aguayo, nez-Vacas, additional, Pedraza-Arévalo, Sergio, additional, Enrique, Gómez-Gómez, additional, León-González, Antonio J., additional, Martínez-Fuentes, Antonio J., additional, Castaño, Antonio J., additional, Gahete, Manuel D., additional, and Luque, Raúl M., additional

Published
2021
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53. JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

Author

Paschalis, Alec, primary, Welti, Jonathan, additional, Neeb, Antje J., additional, Yuan, Wei, additional, Figueiredo, Ines, additional, Pereira, Rita, additional, Ferreira, Ana, additional, Riisnaes, Ruth, additional, Rodrigues, Daniel Nava, additional, Jiménez-Vacas, Juan M., additional, Kim, Soojin, additional, Uo, Takuma, additional, Micco, Patrizio Di, additional, Tumber, Anthony, additional, Islam, Md. Saiful, additional, Moesser, Marc A., additional, Abboud, Martine, additional, Kawamura, Akane, additional, Gurel, Bora, additional, Christova, Rossitza, additional, Gil, Veronica S., additional, Buroni, Lorenzo, additional, Crespo, Mateus, additional, Miranda, Susana, additional, Lambros, Maryou B., additional, Carreira, Suzanne, additional, Tunariu, Nina, additional, Alimonti, Andrea, additional, Al-Lazikani, Bissan, additional, Schofield, Christopher J., additional, Plymate, Stephen R., additional, Sharp, Adam, additional, and de Bono, Johann S., additional

Published
2021
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54. Cytotoxic effect of hydroxytyrosol and its semisynthetic derivatives against prostate cancer cells

Author

León-González, Antonio J., primary, Luque, Raúl M., primary, Sáez-Martínez, Prudencio, additional, Jiménez-Vacas, Juan M., additional, Herrero-Aguayo, Vicente, additional, Montero Hidalgo, Antonio J., additional, Gómez-Gómez, Enrique, additional, Madrona, Andrés, additional, Castaño, Justo P., additional, Espartero, José L., additional, and Gahete, Manuel D., additional

Published
2020
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55. Clinical, Cellular, and Molecular Evidence of the Additive Antitumor Effects of Biguanides and Statins in Prostate Cancer

Author

Jiménez-Vacas, Juan M, primary, Herrero-Aguayo, Vicente, additional, Montero-Hidalgo, Antonio J, additional, Sáez-Martínez, Prudencio, additional, Gómez-Gómez, Enrique, additional, León-González, Antonio J, additional, Fuentes-Fayos, Antonio C, additional, Yubero-Serrano, Elena M, additional, Requena-Tapia, María J, additional, López, Miguel, additional, Castaño, Justo P, additional, Gahete, Manuel D, additional, and Luque, Raúl M, additional

Published
2020
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56. Influence of Obesity in the miRNome: miR-4454, a Key Regulator of Insulin Response Via Splicing Modulation in Prostate

Author

Herrero-Aguayo, Vicente, primary, Jiménez-Vacas, Juan M, additional, Sáez-Martínez, Prudencio, additional, Gómez-Gómez, Enrique, additional, López-Cánovas, Juan L, additional, Garrido-Sánchez, Lourdes, additional, Herrera-Martínez, Aura D, additional, García-Bermejo, Laura, additional, Macías-González, Manuel, additional, López-Miranda, José, additional, Castaño, Justo P, additional, Gahete, Manuel D, additional, and Luque, Raúl M, additional

Published
2020
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58. Influence of obesity in the miRNome landscape: miR-4454, a tissue-specific regulator of insulin response

Author

Sáez-Martínez, Prudencio, primary, Herrero-Aguayo, Vicente, additional, Jiménez-Vacas, Juan M, additional, López-Cánovas, Juan L, additional, Garrido-Sánchez, Lourdes, additional, Macías-González, Manuel, additional, López-Miranda, José, additional, Gómez--Gómez, Enrique, additional, Castaño-Fuentes, Justo P, additional, Gahete-Ortíz, Manuel D, additional, and Luque-Huertas, Raúl M, additional

Published
2020
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59. Unleashing the Diagnostic, Prognostic and Therapeutic Potential of the Neuronostatin/GPR107 System in Prostate Cancer

Author

Sáez-Martínez, Prudencio, primary, Jiménez-Vacas, Juan M., additional, León-González, Antonio J., additional, Herrero-Aguayo, Vicente, additional, Montero Hidalgo, Antonio J., additional, Gómez-Gómez, Enrique, additional, Sánchez-Sánchez, Rafael, additional, Requena-Tapia, María J., additional, Castaño, Justo P., additional, Gahete, Manuel D., additional, and Luque, Raúl M., additional

Published
2020
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60. Clinical Utility of Ghrelin-O-Acyltransferase (GOAT) Enzyme as a Diagnostic Tool and Potential Therapeutic Target in Prostate Cancer

Author

Jiménez-Vacas, Juan M., primary, Gómez-Gómez, Enrique, additional, Montero-Hidalgo, Antonio J., additional, Herrero-Aguayo, Vicente, additional, L-López, Fernando, additional, Sánchez-Sánchez, Rafael, additional, Guler, Ipek, additional, Blanca, Ana, additional, Méndez-Vidal, María José, additional, Carrasco, Julia, additional, Lopez-Miranda, José, additional, Requena-Tapia, María J., additional, Castaño, Justo P., additional, Gahete, Manuel D., additional, and Luque, Raúl M., additional

Published
2019
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62. Mouse models of endocrine tumors

Author

Gahete, Manuel D, primary, Jiménez-Vacas, Juan M, additional, Alors-Pérez, Emilia, additional, Herrero-Aguayo, Vicente, additional, Fuentes-Fayos, Antonio C, additional, Pedraza-Arévalo, Sergio, additional, Castaño, Justo P, additional, and Luque, Raúl M, additional

Published
2019
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63. Clinical, Cellular, and Molecular Evidence of the Additive Antitumor Effects of Biguanides and Statins in Prostate Cancer.

Author

Jiménez-Vacas, Juan M., Herrero-Aguayo, Vicente, Montero-Hidalgo, Antonio J., Sáez-Martínez, Prudencio, Gómez-Gómez, Enrique, León-González, Antonio J., Fuentes-Fayos, Antonio C., Yubero-Serrano, Elena M., Requena-Tapia, María J., López, Miguel, Castaño, Justo P., Gahete, Manuel D., and Luque, Raúl M.

Subjects
ANDROGEN receptors, PROSTATE cancer, CASTRATION-resistant prostate cancer, INSULIN-like growth factor receptors, PACLITAXEL, SOMATOMEDIN C, TANDEM repeats, EXTRACELLULAR signal-regulated kinases
Published
2021
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64. Influence of Obesity in the miRNome: miR-4454, a Key Regulator of Insulin Response Via Splicing Modulation in Prostate.

Author

Herrero-Aguayo, Vicente, Jiménez-Vacas, Juan M., Sáez-Martínez, Prudencio, Gómez-Gómez, Enrique, López-Cánovas, Juan L., Garrido-Sánchez, Lourdes, Herrera-Martínez, Aura D., García-Bermejo, Laura, Macías-González, Manuel, López-Miranda, José, Castaño, Justo P., Gahete, Manuel D., and Luque, Raúl M.

Subjects
RNA splicing, INSULIN receptors, INSULIN, OBESITY, LEPTIN, HYPERINSULINISM, SOMATOMEDIN, RNA metabolism
Published
2021
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65. Plasma ghrelin O-acyltransferase (GOAT) enzyme levels: A novel non-invasive diagnosis tool for patients with significant prostate cancer

Author

Gómez-Gómez, Enrique, primary, Jiménez-Vacas, Juan M., additional, Carrasco-Valiente, Julia, additional, Herrero-Aguayo, Vicente, additional, Blanca-Pedregosa, Ana M., additional, León-González, Antonio J., additional, Valero-Rosa, José, additional, Fernández-Rueda, José L., additional, González-Serrano, Teresa, additional, López-Miranda, José, additional, Gahete, Manuel D., additional, Castaño, Justo P., additional, Requena-Tapia, María J., additional, and Luque, Raúl M., additional

Published
2018
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66. The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness

Author

Hormaechea-Agulla, Daniel, primary, Gahete, Manuel D., additional, Jiménez-Vacas, Juan M., additional, Gómez-Gómez, Enrique, additional, Ibáñez-Costa, Alejandro, additional, L-López, Fernando, additional, Rivero-Cortés, Esther, additional, Sarmento-Cabral, André, additional, Valero-Rosa, José, additional, Carrasco-Valiente, Julia, additional, Sánchez-Sánchez, Rafael, additional, Ortega-Salas, Rosa, additional, Moreno, María M., additional, Tsomaia, Natia, additional, Swanson, Steve M., additional, Culler, Michael D., additional, Requena, María J., additional, Castaño, Justo P., additional, and Luque, Raúl M., additional

Published
2017
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67. The oncogenic role of the spliced somatostatin receptor sst5TMD4 variant in prostate cancer

Author

Hormaechea‐Agulla, Daniel, primary, Jiménez‐Vacas, Juan M., additional, Gómez‐Gómez, Enrique, additional, López, Fernando L.‐, additional, Carrasco‐Valiente, Julia, additional, Valero‐Rosa, José, additional, Moreno, María M., additional, Sánchez‐Sánchez, Rafael, additional, Ortega‐Salas, Rosa, additional, Gracia‐Navarro, Francisco, additional, Culler, Michael D., additional, Ibáñez‐Costa, Alejandro, additional, Gahete, Manuel D., additional, Requena, María J., additional, Castaño, Justo P., additional, and Luque, Raúl M., additional

Published
2017
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68. Oncogenic Role of Secreted Engrailed Homeobox 2 (EN2) in Prostate Cancer.

Author

Gómez-Gómez, Enrique, Jiménez-Vacas, Juan M., Pedraza-Arévalo, Sergio, López-López, Fernando, Herrero-Aguayo, Vicente, Hormaechea-Agulla, Daniel, Valero-Rosa, José, Ibáñez-Costa, Alejandro, León-González, Antonio J., Sánchez-Sánchez, Rafael, González-Serrano, Teresa, Requena-Tapia, Maria J., Castaño, Justo P., Carrasco-Valiente, Julia, Gahete, Manuel D., and Luque, Raúl M.

Subjects
*PROSTATE cancer, *CELL migration, *CELL proliferation, *INDEPENDENT sets, *CELL lines
Abstract

Engrailed variant-2 (EN2) has been suggested as a potential diagnostic biomarker; however, its presence and functional role in prostate cancer (PCa) cells is still controversial or unknown. Here, we analyzed 1) the expression/secretion profile of EN2 in five independent samples cohorts from PCa patients and controls (prostate tissues and/or urine) to determine its utility as a PCa biomarker; and 2) the functional role of EN2 in normal (RWPE1) and tumor (LNCaP/22Rv1/PC3) prostate cells to explore its potential value as therapeutic target. EN2 was overexpressed in our two cohorts of PCa tissues compared to control and in tumor cell lines compared with normal-like prostate cells. This profile was corroborated in silico in three independent data sets [The Cancer Genome Atlas(TCGA)/Memorial Sloan Kettering Cancer Center (MSKCC)/Grasso]. Consistently, urine EN2 levels were elevated and enabled discrimination between PCa and control patients. EN2 treatment increased cell proliferation in LNCaP/22Rv1/PC3 cells, migration in RWPE1/PC3 cells, and PSA secretion in LNCaP cells. These effects were associated, at least in the androgen-sensitive LNCaP cells, with increased AKT and androgen-receptor phosphorylation levels and with modulation of key cancer-associated genes. Consistently, EN2 treatment also regulated androgen-receptor activity (full-length and splicing variants) in androgen-sensitive 22Rv1 cells. Altogether, this study demonstrates the potential utility of EN2 as a non-invasive diagnostic biomarker for PCa and provides novel and valuable information to further investigate its putative utility to develop new therapeutic tools in PCa. [ABSTRACT FROM AUTHOR]

Published
2019
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