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52. Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front.

Author

Tadayuki Oshima, Jing Shan, Takuya Okugawa, Xin Chen, Kazutoshi Hori, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, and Hiroto Miwa

Subjects
Medicine, Science
Abstract

BACKGROUND: Claudins are known as tight junction proteins, and their expression pattern in gastric cancer is still controversial. The relationship between the expression patterns of tight junction proteins and tumor proliferation in early gastric cancer is still far from clear. AIMS: To investigate the expression patterns of claudin-18 and Ki-67 in early gastric cancer at the invasive front and surrounding normal gastric mucosa and to investigate the biological function of claudin-18 in the proliferation and invasion of cancer cells. METHODS: Seventy-five early gastric cancer lesions removed via endoscopic mucosal resection or endoscopic submucosal resection were evaluated. All gastric cancer lesions were diagnosed as differentiated adenocarcinoma using the Japanese Classification of Gastric Carcinoma. To assess epithelial proliferation, immunostaining with Ki-67 was performed, and the labeling index was calculated. To assess the expression of epithelial tight junction proteins, immunofluorescent staining of claudin-18 was performed. The immunoreactivity of claudin-18 was graded according to the number of stained cells. Correlation analysis was performed by Spearman's rank correlation coefficient. Transfection of claudin-18 small interfering RNA (siRNA) was accomplished in MKN74, a claudin-18-positive gastric cancer cell line, to investigate the effect of claudin-18 on proliferation and invasion of cancer cells. RESULTS: Claudin-18 was significantly down-regulated in gastric cancer compared to surrounding gastric normal mucosa or intestinal metaplasia. The Ki-67 labeling index of gastric cancer at the invasive front was inversely correlated with the claudin-18 level, but that at the mucosal lesion was not correlated. Claudin-18 knockdown significantly promoted the proliferation of MKN74 compared with control siRNA-transfected cells. MKN74 invasion increased significantly with claudin-18 siRNA transfection compared with control siRNA transfection. CONCLUSIONS: Down-regulation of claudin-18 is associated with the proliferative potential at the invasive front of gastric cancer, suggesting that it has a pivotal role in gastric cancer progression.

Published
2013
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58. A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs

Author

Shue, Yan Ting, Drainas, Alexandros P, Li, Nancy Yanzhe, Pearsall, Sarah M, Morgan, Derrick, Sinnott-Armstrong, Nasa, Hipkins, Susan Q, Coles, Garry L, Lim, Jing Shan, Oro, Anthony E, Simpson, Kathryn L, Dive, Caroline, and Sage, Julien

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Lung, Aetiology, 2.1 Biological and endogenous factors, Cell Differentiation, Humans, Lung Neoplasms, Neuroendocrine Cells, Receptors, Notch
Abstract

The Notch pathway is a conserved cell-cell communication pathway that controls cell fate decisions. Here we sought to determine how Notch pathway activation inhibits the neuroendocrine cell fate in the lungs, an archetypal process for cell fate decisions orchestrated by Notch signaling that has remained poorly understood at the molecular level. Using intratumoral heterogeneity in small-cell lung cancer as a tractable model system, we uncovered a role for the transcriptional regulators REST and YAP as promoters of the neuroendocrine to non-neuroendocrine transition. We further identified the specific neuroendocrine gene programs repressed by REST downstream of Notch in this process. Importantly, we validated the importance of REST and YAP in neuroendocrine to non-neuroendocrine cell fate switches in both developmental and tissue repair processes in the lungs. Altogether, these experiments identify conserved roles for REST and YAP in Notch-driven inhibition of the neuroendocrine cell fate in embryonic lungs, adult lungs, and lung cancer.

Published
2022

60. Screw Dynamics of the Upper Limb of a Humanoid Robot

Author

Sun, Han-Lin, Zhao, Dong-Jie, Zhao, Jing-Shan, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Yang, Huayong, editor, Liu, Honghai, editor, Zou, Jun, editor, Yin, Zhouping, editor, Liu, Lianqing, editor, Yang, Geng, editor, Ouyang, Xiaoping, editor, and Wang, Zhiyong, editor

Published
2023
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61. A Construction Robot Based on Mobile Manipulator and Sensor Fusion

Author

Ji, Junjie, Wei, Songtao, Zhao, Jing-Shan, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, and Liu, Xinjun, editor

Published
2023
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62. Overview of DDoS Attack Research Under SDN

Author

Guo, Lei, Jing, Shan, Zhao, Chuan, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Xu, Yuan, editor, Yan, Hongyang, editor, Teng, Huang, editor, Cai, Jun, editor, and Li, Jin, editor

Published
2023
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63. Research and Practice of Case Teaching in Network Engineering Course Teaching Under OBE Concept

Author

Wang, Qian, Zhao, Chuan, Jing, Shan, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Yau, Yung, editor, and Hage Chehade, Fadi, editor

Published
2023
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64. Overview of Data Center Link Load Balancing Technology Based on SDN

Author

Hao, Feifan, Jing, Shan, Zhao, Chuan, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Joby, P. P., editor, Balas, Valentina E., editor, and Palanisamy, Ram, editor

Published
2023
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72. A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects

Author

Yang, Xin-Mei, Yang, Yang, Yao, Bu-Fan, Ye, Pan-Pan, Xu, Yan, Peng, Shao-Ping, Yang, Yu-Mei, Shu, Pan, Li, Pei-Jin, Li, Shan, Hu, Hong-Lin, Li, Qian, Song, Lin-Lin, Chen, Ke-Guang, Zhou, Hai-Yan, Zhang, Ye-Hui, Zhao, Fu-Rong, Tang, Bo-Hao, Zhang, Wei, Zhang, Xin-Fang, Fu, Shu-Meng, Hao, Guo-Xiang, Zheng, Yi, Shen, Jing-Shan, Xu, Ye-Chun, Jiang, Xiang-Rui, Zhang, Lei-Ke, Tang, Ren-Hong, and Zhao, Wei

Published
2023
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95. FL-DP: Differential Private Federated Neural Network

Author

Irfan, Muhammad Maaz, Wang, Lin, Ali, Sheraz, Jing, Shan, Zhao, Chuan, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin (Sherman), Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Shi, Wenbo, editor, Chen, Xiaofeng, editor, and Choo, Kim-Kwang Raymond, editor

Published
2022
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96. Planning and Deployment of IPv6 Campus Network Based on eNSP

Author

Jing, Shan, Cheng, Junjie, Wang, Qian, Zhao, Qi, Xiao, Bin, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Hung, Jason C., editor, Chang, Jia-Wei, editor, Pei, Yan, editor, and Wu, Wei-Chen, editor

Published
2022
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97. Efficient Federated Learning Framework Based on Multi-Key Homomorphic Encryption

Author

Zhang, Qian, Jing, Shan, Zhao, Chuan, Zhang, Bo, Chen, Zhenxiang, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Barolli, Leonard, editor

Published
2022
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