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The red meat supply chain is a complex network transferring product from producers to consumers in a safe and secure way. There can be times when fragmentation can arise within the supply chain, which could be exploited. This risk needs reduction so that meat products enter the market with the desired attributes. Rapid Evaporative Ionisation Mass Spectrometry (REIMS) is a novel ambient mass spectrometry technique originally developed for rapid and accurate classification of biological tissue which is now being considered for use in a range of additional applications. It has subsequently shown promise for a range of food provenance, quality and safety applications with its ability to conduct ex vivo and in situ analysis. These are regarded as critical characteristics for technologies which can enable real-time decision making in meat processing plants and more broadly throughout the sector. This review presents an overview of the REIMS technology, and its application to the areas of provenance, quality and safety to the red meat industry, particularly in an Australian context.

Shockwaves generate instantaneous high pressures, which could affect meat shelf-life or quality. This study assessed microbiological counts, pH, drip, cook and moisture loss and texture of striploin (longissimus lumborum) and brisket (pectoralis profundus) treated with electrical shockwave (25 kV, 8 pulses) and subsequently stored (−0.5 °C) for 0, 4, 8, 12, 16 and 20 weeks. Shockwave did not affect total viable counts (p>0.05), with all samples considered microbiologically acceptable ( 0.05). Shockwave × storage time increased moisture losses in striploin (p

Mitochondrial disorders are a clinically and biochemically diverse group of disorders which may involve multiple organ systems. General anaesthesia (GA) poses a potential risk of decompensation in children with mitochondrial disorders, and there is little guidance for anaesthetists and other clinicians regarding the optimal anaesthetic agents and perioperative management to provide to patients with mitochondrial disease[15]. The aim of this review was to document adverse events and perioperative complications from GA in patients with genetically confirmed mitochondrial disorders. A retrospective chart review of patients with genetically confirmed mitochondrial disorders who had undergone GA was undertaken. The indication for GA, anaesthetic agents utilised, length of admission and post anaesthetic complications were documented and analysed. Twenty-six patients with genetically proven mitochondrial disease underwent 65 GAs. Thirty-four (52%), received propofol as their induction agent. Thirty-three (51%) patients received sevoflurane for the maintenance of anaesthesia, while 8 (12%) received isoflurane and 24 (37%) received propofol. The duration of most GAs was short with 57 (87%) lasting less than 1 h. Perioperative complications occurred in five patients while under GA including ST segment depression, hypotension and metabolic acidosis in one. All five patients were stabilised successfully and none required ICU admission as a consequence of their perioperative complications. The duration of hospital stay post GA was24 h in 25 (38%) patients.No relationship between choice of anaesthetic agent and subsequent perioperative complication was observed. It is likely that individual optimisation on a case-by-case basis is more important overall than choice of any one particular technique. What is Known: • General anaesthesia (GA) poses a potential risk of decompensation in children with mitochondrial disorders. • There is a great diversity in the anaesthetic approaches undertaken in this cohort, and little guidance exists for anaesthetists and other clinicians regarding the optimal anaesthetic agents and perioperative management to provide to patients with mitochondrial disease. What is New: • In this study of 26 patients with genetically confirmed mitochondrial disease who underwent 65 GAs, no relationship between choice of anaesthetic agent and subsequent perioperative complication was observed • It is likely that individual optimisation on a case-by-case basis is more important overall than choice of any one particular technique.

In divided societies, the promotion of cross-cultural contact through the education system has been central to efforts to improve intergroup relations. This approach is informed by an understanding of the contact hypothesis, which suggests that positive contact with a member of a different group should contribute to improvements in attitudes towards the group as a whole. While a substantial body of research provides support for contact theory, critics have argued that its emphasis on harmonious encounters can result in the neglect of group differences and associated issues of conflict and discrimination during contact. The research discussed in this article explores this tension with reference to two shared education projects in Northern Ireland. Research data, gathered primarily through interviews with pupils, confirms that divisive issues are rarely addressed during contact and explores several influences on this: the nature of pupils’ relationships, the programme structure, and the prevailing social norms of avoidance.

Dysfunction of mitochondrial gene expression, caused by mutations in either the mitochondrial or nuclear genomes, is associated with a diverse group of human disorders characterized by impaired mitochondrial respiration. Within this group, an increasing number of mutations have been identified in nuclear genes involved in mitochondrial RNA metabolism. For instance, pathogenic mutations have been identified in the genes encoding enzymes involved in the precursor transcript processing, including ELAC2. The ELAC2 gene codes for the mitochondrial RNase Z, which is responsible for endonucleolytic cleavage of the 3’ ends of mitochondrial pre-tRNAs. Here, we report the identification of sixteen novel ELAC2 variants in individuals presenting with mitochondrial respiratory chain deficiency, hypertrophic cardiomyopathy and lactic acidosis. We provided further evidence for the pathogenicity of the three previously reported variants by studying the RNase Z activity in an in vitro system and applied this recombinant system to investigate all novel missense variants, confirming the pathogenic role of these new ELAC2 mutations. We also modelled the residues affected by missense mutation in solved RNase Z structures, providing insight into enzyme structure and function. Finally, we show that primary fibroblasts from the individuals with novel ELAC2 variants have elevated levels of unprocessed mitochondrial RNA precursors. Our study thus broadly confirms the correlation of ELAC2 variants with severe infantile-onset forms of hypertrophic cardiomyopathy and mitochondrial respiratory chain dysfunction. One rare missense variant associated with the occurrence of prostate cancer (p.Arg781His) impairs the mitochondrial RNase Z activity of ELAC2, possibly indicating a functional link between tumorigenesis and mitochondrial RNA metabolism.

The Metabolic Dietetic Team in the National Centre for Inherited Metabolic Disorders (NCIMD) in Ireland deals with approximately 120 weekly phenylalanine (Phe) levels for both adults and children. A review of 500 Phe levels highlighted that 52% of the results were within the target range. Collaboration between information and communication technologies (ICT) departments, metabolic laboratory, and metabolic dietitians enabled the development of the PKU texting system. Following a successful pilot study, the system was then offered to all PKU patients aged over 2 years. The Phe is analysed and authorised on the laboratory system. The demographics are matched with the patient mobile phone number. Text messages are then validated and sent by the dietitian via a web portal using the Defero SMS texting service. Approximately 290 patients/families currently use the texting system. In order to assess the effectiveness of this quality improvement initiative, a patient survey was carried out in 2017. This showed 87% rated the system as either very good or excellent. 94% agreed it was time saving. 84% felt there was no influence on dietary compliance. Analysis of financial implications on dietetic time over 21 months revealed savings of €3,275 and 580 hours of dietetic time. There is no evidence, two years after implementation, that the system has had an effect on either the Phe levels in terms of recommended range or frequency of sampling.

Short-chain enoyl-CoA hydratase (SCEH or ECHS1) deficiency is a rare inborn error of metabolism caused by biallelic mutations in the gene ECHS1 (OMIM 602292). Clinical presentation includes infantile-onset severe developmental delay, regression, seizures, elevated lactate, and brain MRI abnormalities consistent with Leigh syndrome (LS). Characteristic abnormal biochemical findings are secondary to dysfunction of valine metabolism. We describe four patients from two consanguineous families (one Pakistani and one Irish Traveler), who presented in infancy with LS. Urine organic acid analysis by GC/MS showed increased levels of erythro-2,3-dihydroxy-2-methylbutyrate and 3-methylglutaconate (3-MGC). Increased urine excretion of methacrylyl-CoA and acryloyl-CoA related metabolites analyzed by LC-MS/MS, were suggestive of SCEH deficiency; this was confirmed in patient fibroblasts. Both families were shown to harbor homozygous pathogenic variants in the ECHS1 gene; a c.476A > G (p.Gln159Arg) ECHS1variant in the Pakistani family and a c.538A > G, p.(Thr180Ala) ECHS1 variant in the Irish Traveler family. The c.538A > G, p.(Thr180Ala) ECHS1 variant was postulated to represent a Canadian founder mutation, but we present SNP genotyping data to support Irish ancestry of this variant with a haplotype common to the previously reported Canadian patients and our Irish Traveler family. The presence of detectable erythro-2,3-dihydroxy-2-methylbutyrate is a nonspecific marker on urine organic acid analysis but this finding, together with increased excretion of 3-MGC, elevated plasma lactate, and normal acylcarnitine profile in patients with a Leigh-like presentation should prompt consideration of a diagnosis of SCEH deficiency and genetic analysis of ECHS1. ECHS1 deficiency can be added to the list of conditions with 3-MGA.

A low methionine diet is the mainstay of treatment for pyridoxine nonresponsive homocystinuria (HCU). There are various guidelines for recommended protein intakes for HCU and clinical practice varies. Poor growth has been associated with low cystine levels. This retrospective review of 48 Irish pyridoxine nonresponsive HCU patients assessed weight, height, body mass index (BMI), protein intake, and metabolic control up to 18 years at nine set time points. Patients diagnosed through newborn screening (NBS) were compared to late diagnosed (LD) patients. At 18 years the LD group (n=12, mean age at diagnosis 5.09 years) were heavier (estimated effect +4.97 Kg,P=0.0058) and taller (estimated effect +7.97 cmP=0.0204) than the NBS group (n=36). There was no difference in growth rate between the groups after 10 years of age. The HCU population were heavier and taller than the general population by one standard deviation with no difference in BMI. There was no association between intermittently low cystine levels and height. Three protein intake guidelines were compared; there was no difference in adult height between those who met the lowest of the guidelines (Genetic Metabolic Dietitians International) and those with a higher protein intake.

Background Infants presenting with lysosomal acid lipase deficiency have marked failure to thrive, diarrhea, massive hepatosplenomegaly, anemia, rapidly progressive liver disease, and death typically in the first 6 months of life; the only available potential treatment has been hematopoietic stem cell transplantation, which is associated with high morbidity and mortality in this population. The study objective was to evaluate safety and efficacy (including survival) of enzyme replacement with sebelipase alfa in infants with lysosomal acid lipase deficiency. This is an ongoing multicenter, open-label, phase 2/3 study conducted in nine countries. The study enrolled infants with growth failure prior to 6 months of age with rapidly progressive lysosomal acid lipase deficiency; they received once-weekly doses of sebelipase alfa initiated at 0.35 mg/kg with intrapatient dose escalation up to 5 mg/kg. The main outcome of interest is survival to 12 months and survival beyond 24 months of age. Results Nine patients were enrolled; median age at baseline was 3.0 months (range 1.1–5.8 months). Sixty-seven percent (exact 95% CI 30%–93%) of sebelipase alfa–treated infants survived to 12 months of age compared with 0% (exact 95% CI 0%–16%) for a historical control group (n = 21). Patients who survived to age 12 months exhibited improvements in weight-for-age, reductions in markers of liver dysfunction and hepatosplenomegaly, and improvements in anemia and gastrointestinal symptoms. Three deaths occurred early (first few months of life), two patients died because of advanced disease, and a third patient died following complications of non-protocol-specified abdominal paracentesis. A fourth death occurred at 15 months of age and was related to other clinical conditions. The five surviving patients have survived to age ≥24 months with continued sebelipase alfa treatment; all have displayed marked improvement in growth parameters and liver function. Serious adverse events considered related to sebelipase alfa were reported in one of the nine infants (infusion reaction: tachycardia, pallor, chills, and pyrexia). Most infusion-associated reactions were mild and non-serious. Conclusion Sebelipase alfa markedly improved survival with substantial clinically meaningful improvements in growth and other key disease manifestations in infants with rapidly progressive lysosomal acid lipase deficiency Trial registration Clinicaltrials.gov NCT01371825. Registered 9 June 2011. Electronic supplementary material The online version of this article (doi:10.1186/s13023-017-0587-3) contains supplementary material, which is available to authorized users.

We present new SDSS and Washington photometry of the young, outer-halo stellar system, Segue 3. Combined with archival VI-observations, our most consistent results yield: $Z=0.006$, $\log(Age)=9.42$, $(m-M)_0=17.35$, $E(B-V)=0.09$, with a high binary fraction of $0.39\pm 0.05$, using the Padova models. We confirm that mass segregation has occurred, supporting the hypothesis that this cluster is being tidally disrupted. A 3-parameter King model yields a cluster radius of $r_{cl}=0.017^\circ$, a core radius of $r_{c}=0.003^\circ$, and a tidal radius of $r_t=0.04^\circ \pm 0.02^\circ$. A comparison of Padova and Dartmouth model-grids indicates that the cluster is not significantly $\alpha$-enhanced, with a mean [Fe/H]$=-0.55^{+0.15}_{-0.12}$ dex, and a population age of only $2.6\pm 0.4$ Gyr. We rule out a statistically-significant age spread at the main sequence turnoff because of a narrow subgiant branch, and discuss the role of stellar rotation and cluster age, using Dartmouth and Geneva models: approximately 70% of the Seg 3 stars at or below the main sequence turnoff have enhanced rotation. Our results for Segue 3 indicate that it is younger and more metal-rich than all previous studies have reported to-date. From colors involving Washington-C and SDSS-u filters, we identify several giants and a possible blue-straggler for future follow-up spectroscopic studies, and we produce spectral energy distributions of previously known members and potential Segue 3 sources with Washington ($CT_1$), Sloan (ugri), and VI-filters. Segue 3 shares the characteristics of unusual stellar systems which have likely been stripped from external dwarf galaxies as they are being accreted by the Milky Way, or that have been formed during such an event. Its youth, metallicity, and location are all inconsistent with Segue 3 being a cluster native to the Milky Way., Comment: 24 pages, 13 figures, accepted for publication in AJ

This article considers how the education systems of divided societies have been shaped in response to the experience of ethnic and religious conflict. The analysis identifies two competing priorities in such contexts – the development of social cohesion and the protection of cultural, ethnic and religious identities – and explores how these may be reconciled through a model of ‘shared education’. Drawing on research evidence and recent experience of shared education in Northern Ireland, the Former Yugoslav Republic of Macedonia and Cyprus, we reflect on the advantages and challenges of this model in areas experiencing conflict and division.

As Northern Ireland transitions from violence to sustainable peace, one area in particular that remains deeply divided is the parallel education system that operates for Catholic and Protestant pupils. Working within the existing system of separate education, and underpinned by contact theory, the Sharing Education Programme (SEP) was launched in 2007 to deliver shared classes for pupils from the different sectors. While SEP is a relatively new initiative, evidence suggests that the programme positively impacts intergroup attitudes and behaviours of participants, and contrary to existing polemic that denounces the separate faith schools as a site for reconciliation in divided societies, the effectiveness of the programme suggests that separate education can be harnessed to promote more positive intergroup relations. Indeed, we argue that the value of the shared education approach lies in the fact that it can balance the aspirations of those who advocate separate education as a fundamental right in liberal democratic societies, and those who see integrated or common education as the only solution to ethnic/racial divisions. This ideological bridging enhances the appeal of the shared education model in other similarly divided jurisdictions – a point taken up in the discussion. * Danielle Blaylock is a Post-Doctoral Research Fellow in the Centre for Shared Education in the School of Education at Queen’s University, Belfast. Her main research interests and areas of expertise are group process and intergroup relations, intergroup contact theory, and the role of education in divided societies. Her work is closely associated with the social identity theory. ** Professor Joanne Hughes is Director of the Centre for Shared Education in the School of Education, Queen’s University, Belfast. Her main research interests are in intergroup relations and the role of education in divided societies. bs_bs_banner

Northern Ireland is still riven by segregation, caught between peace and reconciliation. Extensive survey research shows that inter-group contact has a key role to play in achieving reconciliation, whether through generic contact, cross-group friends (most effective) or indirect. Segregation is most profound in education. The new Shared Education Programme (SEP), which provides children with the opportunity to study with and meet pupils from the other community, has demonstrated benefits. The Northern Ireland Assembly's support for SEP is based on sound psychological principles and robust research evidence.

One approach to tackling problems of division in society has been to promote collaboration and engagement between schools separated on ethno-religious lines. Based on some variant of contact theory, the received wisdom is that inter-group encounters can contribute to prejudice reduction and promote more harmonious relationships. Evidence to support this analysis is convincing; however, relatively little is known about the environmental factors that impede or enhance the potential for contact in different contexts. The importance of understanding such factors is underscored in divided jurisdictions, where separate education has been linked to the perpetuation of division and hostility. This paper adopts a qualitative approach to exploring the impact of two inter-school initiatives in Northern Ireland. The projects are located in contrasting socio-political and demographic environments, and research findings point to very different contact outcomes for participants in each. Seemingly relevant factors includ...

Northern Ireland (NI) is emerging from a violent period in its troubled history and remains a society characterized by segregation between its two main communities. Nowhere is this more apparent than in education, where for the most part Catholic and Protestant pupils are educated separately. During the last 30 years there has been twofold pressure placed on the education system in NI – at one level to respond to intergroup tensions by promoting reconciliation, and at another, to deal with national policy demands derived from a global neoliberalist economic agenda. With reference to current efforts to promote shared education between separate schools, we explore the uneasy dynamic between a school-based reconciliation programme in a transitioning society and system-wide values that are driven by neoliberalism and its organizational manifestation – new managerialism. We argue that whilst the former seeks to promote social democratic ideals in education that can have a potentially transformative effect at the societal level, neoliberal priorities have the potential to both subvert shared education and also to embed it.

Social identity complexity defines people's more or less complex cognitive representations of the interrelationships among their multiple ingroup identities. Being high in complexity is contingent on situational, cognitive, or motivational factors, and has positive consequences for intergroup relations. Two survey studies conducted in Northern Ireland examined the extent to which intergroup contact and distinctiveness threat act as antecedents, and outgroup attitudes as consequences, of social identity complexity. In both studies, contact was positively, and distinctiveness threat negatively, associated with complex multiple ingroup perceptions, whereas respondents with more complex identity structures also reported more favorable outgroup attitudes. Social identity complexity also mediated the effects of contact and distinctiveness threat on attitudes. This research highlights that the extent to which individuals perceive their multiple ingroups in more or less complex and differentiated ways is of central importance to understanding intergroup phenomena.

One manifestation of division and the history of conflict in Northern Ireland is the parallel education system that exists for Protestants and Catholics. Although recent decades have seen some advances in the promotion of integrated education, around 95% of children continue to attend schools separated on ethno-religious lines. In 2007 a programme for sharing education was established. Underpinned by intergroup contact theory, and reflecting educational priorities shared by all school sectors, the programme seeks to offer children from different denominational schools an opportunity to engage with each other on a sustained basis. In this article the authors adopt a quantitative approach to examining the impact of participation in the Sharing Education Programme on a range of outcomes (out-group attitudes, positive action tendencies and out-group trust) via, first, intergroup contact (cross-group friendships) and, second, intergroup anxiety. Their findings confirm the value of contact as a mechanism for promoting more harmonious relationships, and affirm the Sharing Education Programme as an initiative that can help promote social cohesion in a society that remains deeply divided.

Debate continues about the relationship between schools divided on ethno-religious lines and their implications for social cohesion. One argument against the existence of separate schools is that they limit opportunities for children from different groups to engage with each other, promoting intergroup suspicion and sectarianism. Using intergroup contact theory we examine the impact on outgroup attitudes of pupils attending mixed and separate post-primary schools in Northern Ireland. Data were collected through a survey of more than 3,500 pupils and analyses show that, irrespective of school type, intergroup contact at school is strongly associated with more positive orientations to the ethno-religious outgroup. The policy implications of these findings are discussed. © 2013 Taylor and Francis.

We report a female child from an Irish Traveller family presenting with severe intellectual disability, dysmorphic features, renal anomalies, dental caries and cyclical vomiting. Current health issues include global developmental delay, mild concentric left ventricular hypertrophy, dental malocclusion and caries and a single duplex left kidney. The proband and her mother also have multiple epiphyseal dysplasia. Whole-exome sequencing was performed to identify the underlying genetic cause. DNA from the proband was enriched with the Agilent Sure Select v5 Exon array and sequenced on an Illumina HiSeq. Rare homozygous variants were prioritized. Whole-exome sequencing identified three linked homozygous missense variants in THOC6 (c.298T>A, p.Trp100Arg; c.700G>C, p.Val234Leu; c.824G>A, p.Gly275Asp) as the likely cause of this child's intellectual disability syndrome, resulting in a molecular diagnosis of Beaulieu-Boycott-Innes syndrome (BBIS). This is the first report of BBIS in Europe. BBIS has been reported previously in two Hutterite families and one Saudi family. A review of all patients to date shows a relatively homogenous phenotype. Core clinical features include low birth weight with subsequent growth failure, short stature, intellectual disability with language delay, characteristic facies, renal anomalies and dental malocclusion with caries. Some patients also have cardiac defects. All patients show characteristic dysmorphic facial features including a tall forehead with high anterior hairline and deep-set eyes with upslanting palpebral fissures. The coexistence of intellectual disability together with these characteristic facies should provide a diagnostic clue for BBIS during patient evaluation.

The sensory attributes and flavor chemistry of grilled beef striploins (M. longissimus lumborum, n = 42) varying widely in marbling from commercial production types typical for Southern Australia were extensively characterized. Striploins from Angus grass-fed yearlings (5.2-9.9% intramuscular fat), Angus grain-finished steers (10.2-14.9%), and Wagyu grass-fed heifers (7.8-17.5%) were evaluated. Inherent differences between samples from grass- and grain-fed Angus cattle were minimal when the intramuscular fat content was above ∼5%. After adjusting for intramuscular fat, Wagyu samples had more intense flavor and higher tenderness and juiciness compared to Angus grass-fed samples. Grilled beef flavor, dairy fat, and sweetness increased with the marbling level, and sourness and astringency decreased. Tenderness and juiciness increased with the marbling level and were correlated with Warner-Bratzler peak force measurements. Trained panel sensory differences in flavor corresponded with increases in aroma volatiles and changes in nonvolatile flavor compounds. Unsaturated fatty acids with potential health benefits (vaccenic, oleic, and rumenic acids) increased with the level of marbling.

It is generally accepted that education has a significant role to play in anysociety transitioning from conflict to a more peaceful dispensation. Indeed,some have argued that the education system potentially represents the singlemost effective agent of social change with the capacity to bridge ethnicdivision in conflict affected countries. Despite the potential, educationalpolicy-makers grapple with the dilemma as to precisely how school systemscan best facilitate this agenda. This paper thus attempts to shed lightupon the dilemma by exploring pupil identity and associated intergroupattitudes across various school types in Northern Ireland. Five schools wereselected for the study with each one representing a particular sector withinthe Northern Irish education system (maintained grammar, maintainedsecondary, controlled grammar, controlled secondary, integrated). This led toa total sample size of 265 pupils. The main findings show that children acrossseparate Catholic, separate Protestant and mixed Catholic and Protestanteducational contexts construct and interpret identity differently. At thesame time, our data suggest that no one school setting has supremacy inpromoting social cohesion. The implications of these findings are discussed.

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: Study 1 was supported by a grant from the Community Relations Unit, Northern Ireland, awarded to Miles Hewstone, Ed Cairns, and Joanne Hughes. We gratefully acknowledge the Russell Sage Foundation for their grant support for studies 2 and 3. Across one longitudinal and two cross-sectional surveys in Northern Ireland, we tested a model of intergroup relations in which out-group attitudes and behavioral tendencies are predicted by cross-group friendship and positive intergroup appraisals, mediated by intergroup emotions and out-group trust. In study 1, out-group friendship at time 1 predicted out-group trust at time 2 (one year later), controlling for prior out-group trust. In study 2, positive and negative intergroup emotions mediated the effects of friendship on positive and negative behavioral tendencies and attitudes. In study 3, a confirmatory factor analysis indicated that trust and emotions are distinct constructs with unique predictive contributions. We then tested a model in which cross-group friendship predicted intergroup emotions and trust through intimate self-disclosure in out-group friendships. Our findings support an integration of an intergroup emotions framework with research highlighting the importance of cross-group friendship in fostering positive intergroup outcomes. Postprint

Background. In this paper, we focused on mixing in educational settings between members of Catholic and Protestant ethnoreligious groups in Northern Ireland. Aims. In Study 1, we examined whether opportunities for contact at home and at university were associated with greater actual out-group friendships, and whether this friendship was associated with a reduction in prejudice. We also assessed whether the impact of out-group friendships at university was moderated by experience of out-group friendships outside university, such that the prejudice-reducing effect of university friendships was stronger for those with fewer friendships at home. In Study 2, we assessed opportunities for contact and actual out-group friendships at prior stages of the educational system and their relationship with prejudice. Sample(s). In both studies, our participants were students at universities in Northern Ireland (Study 1 N= 304 and Study 2 N= 157). Methods. We analysed the data using multiple regression and structural equation modelling. Results. First, opportunities for contact were positively associated with self-reported out-group friendships in all domains and stages of the educational system. Second, having more out-group friends was associated with reduced prejudice. Finally, the relationship between out-group friendships and current levels of prejudice was moderated by prior levels of out-group friendships (at home in Study 1; and at secondary and primary school in Study 2). Conclusions. Contact, in the form of out-group friendships, was more powerful when it was a novel feature in a person's life. We discuss these findings in terms of the impact of mixing in educational contexts, especially in Northern Ireland, and outline suggestions for future research.

In Northern Ireland, where the majority of children are educated at schools attended mainly by coreligionists, the debate concerning the role of schools in perpetuating intergroup hostilities has recently been reignited. Against questions regarding the efficacy of community relations policy in education, the research reported in this paper employs qualitative methods to examine social identity and intergroup attitudes amongst children attending a state controlled Protestant school and the school’s response to dealing with issues of diversity and difference. Findings suggest a relationship between ethnic isolation experienced by children and negative intergroup social attitudes and the discussion focuses on issues germane to the separateness of the school that are likely to contribute to strong ‘own’ group bias, stereotyping and prejudice. The implication of the school’s separate status for its engagement with a policy framework for relationship building is also considered. The paper concludes with some po...

International audience; In a recent paper, Robert Putnam (2007) challenges the contact hypothesis by arguing that ethnic diversity causes people to 'hunker down' and essentially withdraw themselves from society. Drawing on qualitative data collected from three mixed communities in Northern Ireland, this paper explores the extent and quality of contact experienced by Protestants and Catholics in their everyday lives. Themes emerging from our data are generally consistent with the contact hypothesis. There is also some support for Putnam's theory that mixed environments can induce 'hunkering down' and that inter-group trust may be compromised. However, our data challenge Putnam's argument that these responses are a consequence of 'anomie' or 'social malaise'. Rather, we find that withdrawal from social activity in the neighbourhoods we observed was a calculated response at times of threat, often aimed at protecting existent positive inter-ethnic relations.

In recent years, there has been a general trend in democratic societies to develop and exploit social capital. Reflecting this trend, a recent policy programme for Northern Ireland, A Shared Future, emphasized the importance of relationship building, both within and across communities, and between communities and statutory organizations. The research presented in this paper explores the potential of social capital as a policy concept and the value of the concept for interpreting community dynamics, devising strategies to enhance community relations and development and ultimately building a more sustainable society post-conflict. © Oxford University Press and Community Development Journal. 2008.

Despite some significant political developments and the advent of paramilitary cease-fires, Northern Ireland remains a deeply divided society characterized by high levels of residential segregation. Although a causal link between segregation and intercommunity conflict has not been established, a wealth of research data points to the benefits of intercommunity contact in divided societies. Drawing on theoretical literature from social psychology, this paper explores responses to the out-group in ethnically mixed and segregated Belfast communities. It concludes that the opportunity presented for intergroup contact in the mixed community seems to have, at the very least, an ameliorating effect on the fear and sense of threat posed by the out-group.

Developments in the late 1990s, including paramilitary cease-fires and the advent (albeit, short-lived) of devolved Government, offered a new dispensation from which to appraise the community relations problem in Northern Ireland and advocate policy action. This paper considers an emergent policy framework entitled A Shared Future. Drawing on the experience of delivering better relations through education in Northern Ireland, it argues that whilst A Shared Future reflects progress in how the problem of community relations is defined, many uncritical assumptions are made about the potential of suggested actions to address problems of intergroup fear, mistrust and hostility.

We present Washington photometry of the giant branches of the relatively metal-rich globular cluster NGC 6388 and compare it with 47 Tuc. By examining the spatial distribution of stellar colors across the red giant branch and using spectroscopic data on several bright giants, we found that NGC 6388's center is affected by differential reddening of at least ΔE(B - V) ~ 0.1. Most of the width of the red giant branch is caused by that differential reddening. The southeastern outer regions of the cluster seem to be less affected by variable dust extinction, and we find that NGC 6388 is slightly more metal-rich than 47 Tuc, with a distinct asymptotic giant branch. We have put an upper limit on possible variations in [Fe/H] for NGC 6388, finding that it must be less than ~0.2 dex. It is unlikely that such a small range in metallicity could be responsible for the blue horizontal branch and blue tail stars in a cluster with a metallicity similar to the more massive 47 Tuc, which only exhibits a red horizontal branch.

Bilingual, bi-national schools in Israel aim to educate, together, children from linguistically and culturally diverse Arab and Jewish backgrounds. They reflect an ideological commitment to a more peaceful society and are based on the theoretical premises of the contact hypothesis. In its earliest manifestation, contact theory identified conditions under which inter-group contact was likely to improve negative social attitudes. More recently, and as a consequence of various critical analyses, the theory has evolved to focus more on process or intervening variables during contact, and wider contextual factors that can facilitate or impede the development of better relations. Based on qualitative research in two bilingual/bi-national schools in Israel, this paper examines the nature of the contact experienced by Arabs and Jews in the schools, as well as some of the contextual and process variables that seemingly mediate the quality, and moderate the effectiveness of the inter-group setting. It argues that, ...

In Northern Ireland it is estimated that 35–40 per cent of Protestants and Catholics live in communities divided along ethno-sectarian lines, and some research suggests increasing segregation in recent years. A recent policy initiative to promote a ‘Shared Future’ acknowledges that the problems of residential segregation relate, at least in part, to endemic fear and sense of threat in divided communities. The research presented in this article reflects on this ‘psychological’ analysis of the problem through an exploration of the basis of negative emotional responses in two of Belfast's most segregated areas, and examines potential mediators of more positive responses towards the ‘outgroup’. The article concludes with policy recommendations for mitigating fear and anxiety associated with residential segregation.

Background: Recessive LARS mutations were recently reported to cause a novel syndrome, infantile liver failure syndrome type 1 (ILFS1), in six Irish Travellers. We have since identified four additional patients, including one of Ashkenazi origin, representing the largest ILFS1 cohort to date. Our study aims to define the ILFS1 clinical phenotype to help guide diagnosis and patient management. Methods: We clinically evaluated and reviewed the medical records of ten ILFS1 patients. Clinical features, histopathology and natural histories were compared and patient management strategies reviewed. Results: Early failure to thrive, recurrent liver dysfunction, anemia, hypoalbuminemia and seizures were present in all patients. Most patients (90 %) had developmental delay. Encephalopathic episodes triggered by febrile illness have occurred in 80 % and were fatal in two children. Two patients are currently >28 years old and clinically well. Leucine supplementation had no appreciable impact on patient well-being. However, we suggest that the traditional management of reducing/stopping protein intake in patients with metabolic hepatopathies may not be appropriate for ILFS1. We currently recommend ensuring sufficient natural protein intake when unwell. Conclusions: We report the first non-Irish ILFS1 patient, suggesting ILFS1 may be more extensive than anticipated. Low birth weight, early failure to thrive, anemia and hypoalbuminemia are amongst the first presenting features, with liver dysfunction before age 1. Episodic hepatic dysfunction is typically triggered by febrile illness, and becomes less severe with increasing age. While difficult to anticipate, two patients are currently >28 years old, suggesting that survival beyond childhood may be associated with a favourable long-term prognosis. Health Research Board The Children's Fund for Health, Temple Street Children's University Hospital

Policy initiatives in inter‐group education evolved in Northern Ireland and Israel at around the same time. In each jurisdiction, the emphasis is on improving relations between protagonist groups in ethnically divided societies. Central to this objective and at the core of integrated education (Northern Ireland) and bilingual/bi‐national education (Israel) is sustained contact in a shared learning environment. Based on qualitative research in four schools, this paper examines the nature of the contact experience in two integrated schools in Northern Ireland and two bilingual/bi‐national schools in Israel. Through comparative analysis, and with reference to contact theory, it illuminates some of the contextual and process variables that seemingly mediate the quality and moderate the effectiveness of contact in each school setting.

SummarySpinal fusion surgery for alleviation of intractable lower back pain in humans is currently a primary therapeutic technique, with failure rates averaging between 5 to 35%. Implanted and external source-based electrical stimulation devices have been investigated in an attempt to increase osteogenesis at the fusion site in an attempt to reduce spinal fusion failure rates. The purpose of our study was to evaluate the efficacy of two co-processor systems and an additional system with an SIS generation field at 15.8 mA (rms) using biomechanical, dual-energy X-ray absorptiometry (DXA), and histomorphometric analyses, in rabbits following dorsolateral (= posteriolateral [in humans]) spinal fusion. Fifty-six male New Zealand White underwent bilateral lumbar spinal fusion by performing decortication of the transverse processes of lumbar vertebrae four and five with placement of autogenic cancellous bone graft harvested from the ilial wings. Four study groups were designated based on the type of IES device used for stimulation or as a control. Eight weeks after surgery all subjects were sacrificed and the quality and strength of the fusion masses were compared using radiographic, biomechanical, histomorphometry, and qualitative histological evaluation. While some variation existed within and between groups, Group 2 showed a significant improvement in all parameters measured as compared to the control group (P

This article uses attitudinal data to explore Catholic and Protestant perspectives on community relations and equality since the paramilitary cease fires in 1994. Although attitudes tend to fluctuate with the ‘headline grabbing’ events of the day, the article argues that there are signs that some fundamental changes have taken place in the post cease fire period. Of particular importance in this regard is the positive response recorded by the Catholic community towards government measures to tackle disadvantage and inequality. Equally significant is the protestant response to many of these measures which is often one of ambivalence rather than derision. In so far as the data appear to challenge the ‘zero-sum’ game that traditionally underpins relations between the two communities in Northern Ireland, they provide some grounds for optimism. Yet such optimism is tempered somewhat by the seeds of discontent which are manifest within the protestant community, particularly around issues of equality in employme...

Under the terms of the Belfast Agreement (1998), community relations policy and practice have progressed from tackling symptoms of the conflict towards adopting a more holistic approach that aims to also address its root causes. In an effort to gauge the impact of political and policy developments on relations between the Protestant and the Catholic communities, this paper examines longitudinal survey evidence of attitudes towards community relations issues amongst a representative sample of the Northern Ireland population. The data (collected in 1989, 1996 and 1999) reveal a growing disparity between Protestant and Catholic responses over time that reflect a Catholic community growing in confidence and a Protestant community feeling increasingly marginalised by wider political developments. In the final analysis we argue that the increasingly negative Protestant response reflects a perception that the current conflict resolution model promotes a Nationalist/Republican agenda that de-legitimises Unionist ...

The role of macro‐level processes in determining the effectiveness or otherwise of micro‐level initiatives is a theme that is developed in this paper. Based on efforts to tackle division between Protestants and Catholics in Northern Ireland through cross‐community contact, the paper will argue that the structural context within which contact occurs has important implications for the extent to which achievements of particular encounters are extrapolated to the wider community.

We have observed (with vby filters) a field north of the core of the most massive globular cluster in our galaxy, ω Centauri. We have found a correlation of age and metallicity in a region that avoids the dense core and the inhomogeneous foreground dust emission shown by IRAS. Our observations show that the comparatively metal-rich stars (as defined by the b-y and m1 colors) are younger than the metal-poor stars by at least 3 Gyr. This correlation of metallicity with age suggests that ω Cen has enriched itself over a timescale of about 3 Gyr, and possibly longer. It is remarkable that ejecta from stellar winds combined with supernovae of Type II failed to disperse the cluster's interstellar matter at an earlier epoch but were captured by the cluster instead. Star formation would have ceased as Type Ia supernovae dispersed the remaining interstellar matter. This work and other recent evidence suggests that ω Cen could have been part of a small satellite galaxy in which all the activity occurred before it was captured by the Milky Way.

The last ten years have seen a concerted effort on the part of policy makers in Northern Ireland to address the community relations problem. Ostensibly, there have been significant achievements with a community relations infrastructure now well established and augmented by relevant policy and legislation. Despite this, a consequence of contentious Orange Order parades during the last three summers has been an upsurge in sectarianism and intimidation reminiscent of the worst periods in the troubled history of Northern Ireland. Community relations practitioners and professionals have been the target for much criticism, directed mainly at the effectiveness of the cross‐community initiatives which they have supported. This article examines approaches to community relations in Northern Ireland in the light of these criticisms. On the basis of social psychology and theories of intergroup behaviour, it argues that most interventions currently supported do make some contribution towards improving relatio...

The last ten years have seen the most sustained attempt by the British government to address the underlying problems of segregation and division in Northern Ireland through a reexamination of public policy issues (housing, education, and employment). This paper examines the contribution of one such policy initiative, a “bottom-up” approach to community relations under the auspices of the Central Community Relations Unit. Official evaluations of twenty-two projects are reviewed and assessed against principles of good practice emerging from a growing body of theoretical literature on effective intergroup contact.

In this paper, we focused on mixing in educational settings between members of Catholic and Protestant ethnoreligious groups in Northern Ireland.In Study 1, we examined whether opportunities for contact at home and at university were associated with greater actual out-group friendships, and whether this friendship was associated with a reduction in prejudice. We also assessed whether the impact of out-group friendships at university was moderated by experience of out-group friendships outside university, such that the prejudice-reducing effect of university friendships was stronger for those with fewer friendships at home. In Study 2, we assessed opportunities for contact and actual out-group friendships at prior stages of the educational system and their relationship with prejudice. Sample(s). In both studies, our participants were students at universities in Northern Ireland (Study 1 N= 304 and Study 2 N= 157).We analysed the data using multiple regression and structural equation modelling.First, opportunities for contact were positively associated with self-reported out-group friendships in all domains and stages of the educational system. Second, having more out-group friends was associated with reduced prejudice. Finally, the relationship between out-group friendships and current levels of prejudice was moderated by prior levels of out-group friendships (at home in Study 1; and at secondary and primary school in Study 2).Contact, in the form of out-group friendships, was more powerful when it was a novel feature in a person's life. We discuss these findings in terms of the impact of mixing in educational contexts, especially in Northern Ireland, and outline suggestions for future research.