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65 results on '"KODAMA, Yusuke"'

51. Coronary Arterial Plaque Characterized by Multislice Computed Tomography Predicts Complications Following Coronary Intervention

Author

Kinohira, Yukihiko, primary, Akutsu, Yasushi, additional, Li, Hui-Ling, additional, Hamazaki, Yuji, additional, Sakurai, Masayuki, additional, Saiki, Yuka, additional, Kodama, Yusuke, additional, Nishimura, Hideki, additional, Yamanaka, Hideyuki, additional, Shinozuka, Akira, additional, Gokan, Takehiko, additional, and Katagiri, Takashi, additional

Published
2007
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52. Coronary Arterial Plaque Characterized by Multislice Computed Tomography Predicts Coronary Events Following Coronary Intervention

Author

KINOHIRA, Yukihiko, primary, AKUTSU, Yasushi, additional, LI, Hui-Ling, additional, HAMAZAKI, Yuji, additional, SAKURAI, Masayuki, additional, SAIKI, Yuka, additional, KODAMA, Yusuke, additional, NISHIMURA, Hideki, additional, YAMANAKA, Hideyuki, additional, SHINOZUKA, Akira, additional, GOKAN, Takehiko, additional, and KATAGIRI, Takashi, additional

Published
2006
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53. Significance of Cardiac Sympathetic Nervous System Abnormality for Predicting Origin of Tachyarrhythmia in Patients with a History of Paroxysmal Palpitation

Author

SAIKI, Yuka, primary, AKUTSU, Yasushi, additional, KODAMA, Yusuke, additional, LI, Hui-Ling, additional, KINOHIRA, Yukihiko, additional, ADACHI, Taro, additional, YAMANAKA, Hideyuki, additional, SHINOZUKA, Akira, additional, GOKAN, Takehiko, additional, KOBAYASHI, Youichi, additional, and KATAGIRI, Takashi, additional

Published
2006
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56. Quantitative Analysis Using Overlap Images with Technetium-99m Pyrophosphate Thallium-201 Dual-isotope SPECT to Evaluate Microvascular Reperfusion Injury Following Successful Coronary Intervention in Patients with Acute Myocardial Infarction

Author

NISHIMURA, Hideki, primary, AKUTSU, Yasushi, additional, HAMAZAKI, Yuji, additional, SAKURAI, Masayuki, additional, SHIGEMITSU, Meiei, additional, KODAMA, Yusuke, additional, LI, Hui-Ling, additional, KONDO, Takeshi, additional, EZUMI, Hitoshi, additional, YAMANAKA, Hideyuki, additional, SHINOZUKA, Akira, additional, and KATAGIRI, Takashi, additional

Published
2004
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58. Contractile Reserve, Thallium-201 Reverse Redistribution and Mismatch Between Perfusion and Metabolism in Reperfused Infarct-related Myocardium With Delayed and Incomplete Functional Recovery

Author

Akutsu, Yasushi, primary, Kodama, Yusuke, additional, Nishimura, Hideki, additional, Kinohira, Yukihiko, additional, Li, Hui-Ling, additional, Yamanaka, Hideyuki, additional, Kayano, Hiroyuki, additional, Hamazaki, Yuji, additional, Shinozuka, Akira, additional, and Katagiri, Takashi, additional

Published
2004
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65. Association between loss of hypercoagulable phenotype, clinical features and complement pathway consumption in COVID-19.

Author

Kasugai D, Tanaka T, Suzuki T, Ito Y, Nishida K, Ozaki M, Kutsuna T, Yokoyama T, Kaneko H, Ogata R, Matsui R, Goshima T, Hamada H, Ishii A, Kodama Y, Jingushi N, Ishikura K, Kamidani R, Tada M, Okada H, Yamamoto T, and Goto Y

Subjects
Humans, Prospective Studies, Blood Coagulation, Phenotype, COVID-19, Thrombophilia etiology
Abstract

Background: Coronavirus disease 2019 (COVID-19) features a hypercoagulable state, but therapeutic anticoagulation effectiveness varies with disease severity. We aimed to evaluate the dynamics of the coagulation profile and its association with COVID-19 severity, outcomes, and biomarker trajectories., Methods: This multicenter, prospective, observational study included patients with COVID-19 requiring respiratory support. Rotational thromboelastometry findings were evaluated for coagulation and fibrinolysis status. Hypercoagulable status was defined as supranormal range of maximum clot elasticity in an external pathway. Longitudinal laboratory parameters were collected to characterize the coagulation phenotype., Results: Of 166 patients, 90 (54%) were severely ill at inclusion (invasive mechanical ventilation, 84; extracorporeal membrane oxygenation, 6). Higher maximum elasticity ( P =0.02) and lower maximum lysis in the external pathway ( P =0.03) were observed in severely ill patients compared with the corresponding values in patients on non-invasive oxygen supplementation. Hypercoagulability components correlated with platelet and fibrinogen levels. Hypercoagulable phenotype was associated with favorable outcomes in severely ill patients, while normocoagulable phenotype was not (median time to recovery, 15 days vs. 27 days, P =0.002), but no significant association was observed in moderately ill patients. In patients with severe COVID-19, lower initial C3, minimum C3, CH50, and greater changes in CH50 were associated with the normocoagulable phenotype. Changes in complement components correlated with dynamics of coagulation markers, hematocrit, and alveolar injury markers., Conclusions: While hypercoagulable states become more evident with increasing severity of respiratory disease in patients with COVID-19, normocoagulable phenotype is associated with triggered by alternative pathway activation and poor outcomes., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Kasugai, Tanaka, Suzuki, Ito, Nishida, Ozaki, Kutsuna, Yokoyama, Kaneko, Ogata, Matsui, Goshima, Hamada, Ishii, Kodama, Jingushi, Ishikura, Kamidani, Tada, Okada, Yamamoto and Goto.)

Published
2024
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