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51. Slow Intravenous Iron Administration Does Not Aggravate Oxidative Stress and Inflammatory Biomarkers during Hemodialysis: A Comparative Study between Iron Sucrose and Iron Dextran

Author

Kali Makedou, Vasilios Raptis, Pantelis Sarafidis, Igor Rudenco, Areti Makedou, Pavlos Malindretos, and Dimirios M. Grekas

Subjects
Adult, Male, Anemia, medicine.medical_treatment, Intravenous iron, Inflammation, Pharmacology, Iron sucrose, medicine.disease_cause, Ferric Compounds, Glucaric Acid, Renal Dialysis, medicine, Humans, Iron dextran, Infusions, Intravenous, Serum Albumin, Aged, Aged, 80 and over, Ferric Oxide, Saccharated, Anemia, Iron-Deficiency, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Middle Aged, medicine.disease, Inflammatory biomarkers, Lipoproteins, LDL, Oxidative Stress, C-Reactive Protein, Nephrology, Immunology, Hematinics, Kidney Failure, Chronic, Female, Iron-Dextran Complex, Hemodialysis, Inflammation Mediators, medicine.symptom, business, Biomarkers, Oxidative stress, medicine.drug
Abstract

Background/Aims: Fast intravenous (i.v.) iron administration during hemodialysis (HD) is associated with the augmentation of oxidative stress and the increase in inflammatory biomarkers, which are also induced by the hemodialysis procedure itself. The aim of this study was to investigate if slow i.v. iron administration would aggravate the status of oxidative stress and inflammatory biomarkers during a hemodialysis session. Methods: Twenty dialysis patients 30–92 years of age that were iron replete and had values for hemoglobin, transferrin saturation and serum ferritin among recommended goals were evaluated in three separate hemodialysis sessions. In the first session patients did not receive any iron treatment, whereas during the second and the third session patients received slow (60 min) i.v. infusions of 100 mg of iron sucrose and 100 mg of iron dextran, respectively. Blood samples were drawn before the hemodialysis session, 15 min after the end of iron administration and at the end of the hemodialysis session in all occasions, for the measurement of markers of oxidant stress (oxidized LDL and ischemia-modified albumin) and inflammation (high-sensitivity C-reactive protein, interleukin-6 and tumor necrosis factor-α). Results: Oxidized LDL was not significantly altered during hemodialysis and this pattern was similar between the three occasions studied. In contrast, ischemia-modified albumin was significantly increased and this effect was also not different between the net hemodialysis and the occasions of iron administration. High-sensitivity CRP, IL-6 and TNF-α were all significantly elevated during hemodialysis and again both types of iron administration did not produce significant changes in this pattern. Conclusion: We did not find an increase in the markers of oxidation/inflammation studied, after slow i.v. iron administration during hemodialysis session.

Published
2007
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52. Impact of iron and folic acid supplementation on oxidative stress during pregnancy

Author

L. Kiriazi, Eleni Vagdatli, E. Lymperaki, C. Charisi, Kali Makedou, A. Tsikopoulos, and E. Paliogianni

Subjects
Adult, medicine.medical_specialty, Antioxidant, medicine.medical_treatment, Iron, Physiology, medicine.disease_cause, Young Adult, Folic Acid, Pregnancy, Statistical significance, Medicine, Humans, Volunteer, business.industry, Obstetrics and Gynecology, medicine.disease, Folic acid supplementation, Surgery, Oxidative Stress, Folic acid, Dietary Supplements, Hematinics, Gestation, Female, business, Oxidative stress
Abstract

The aim of the study was to assess serum total antioxidant capacity (TAC) and the impact of supplements on oxidative stress (OS) during pregnancy. Fifty volunteer pregnant women (21-40 years old), in the 12 ± 2 weeks' and 38 ± 2 weeks' gestation of pregnancy (study group), and 25 non-pregnant healthy women (control group) were enrolled. All pregnant women were divided into two age groups (A1: < 35 years and A2: ≥ 35 years) and four groups according to supplementation (B1: iron, B2: folic acid, B3: both and B4: none). Antioxidant activity was assayed using the TAC kit (Cayman Chemical Co.). Level of statistical significance was p < 0.05. Serum TAC values in all pregnant women in the first trimester were significantly lower, as compared with those of the control group. Levels of TAC increased significantly in the third trimester of pregnancy, especially with folic acid or no supplementation. In conclusion, pregnancy is associated with OS, which is promoted by the administration of iron supplementation.

Published
2015

53. Study of frozen low density lipoprotein particles by using nanotechnology

Author

Maria Seitanidou, V. Karagiozaki, Stergios Logothetidis, Maria Trachana, V. Sgouropoulou, and Kali Makedou

Subjects
Mean diameter, Cryopreservation, Adolescent, Atomic force microscopy, Clinical Biochemistry, Healthy subjects, Nanotechnology, General Medicine, Microscopy, Atomic Force, Edta plasma, Lipoproteins, LDL, chemistry.chemical_compound, chemistry, Low-density lipoprotein, Freezing, Low density, Particle, Humans, lipids (amino acids, peptides, and proteins), Ultracentrifuge, Particle Size, Child, Ultracentrifugation
Abstract

Objectives To investigate the impact of freezing in − 80 °C on the structure of isolated low density lipoproteins (LDLs), using nanotechnology, such as Atomic Force Microscopy (AFM). Design and methods Blood EDTA plasma was obtained from healthy subject and used immediately to isolate LDL by sequential ultracentrifugation at 10 °C in 55,000 rpm for 3 h, using a Beckmann XL-90 ultracentrifuge (75Ti rotor), in the presence of KBr in PBS. LDLs were then diluted with PBS until final concentrations of 5 and 15 mg LDL/dl. After initial observation, samples were frozen in − 80 °C for two weeks and observed again after thawing. Experiments were performed in triplicate on two smooth and clean substrates of different hydrophobicity, glass (HOPG) and Si (c-Si). Statistical significance was set at 0.05. Results Macroscopically, LDL particles formed aggregations in a dendroid layout. There were no differences between images taken from both substrates (HOPG and c-Si). Frozen samples presented significantly smaller LDL particles, than fresh ones. In specific, mean diameter of LDL particle in the fresh LDL sample was 19.77 nm, ranging from 13.34 to 28.76 nm. The frozen LDL sample had a mean diameter of 5.2 nm, ranging from 2.0 to 8.0 nm, which was significantly different from the unfrozen. Conclusions Atomic Force Microscopy showed that freezing of LDL causes alterations in their size.

Published
2015

55. Serum vaspin levels in women with and without gestational diabetes mellitus during pregnancy and postpartum

Author

Athina Gkiomisi, David Rousso, Elpida Gavana, Themistoklis Dagklis, Anargyros Kourtis, Athanasios D. Anastasilakis, Stergios A. Polyzos, Kali Makedou, Spyridon Gerou, and Giannoulis C

Subjects
Adult, Blood Glucose, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, Immunology, Adipokine, Carbohydrate metabolism, Biochemistry, chemistry.chemical_compound, Insulin resistance, Pregnancy, Diabetes mellitus, Internal medicine, Immunology and Allergy, Medicine, Humans, Insulin, Molecular Biology, Serpins, business.industry, Quantitative insulin sensitivity check index, Postpartum Period, nutritional and metabolic diseases, Hematology, medicine.disease, Lipids, female genital diseases and pregnancy complications, Uric Acid, Gestational diabetes, Diabetes, Gestational, Endocrinology, Glucose, chemistry, Gestation, Uric acid, Female, Insulin Resistance, business
Abstract

Although vaspin is regarded an insulin-sensitizing adipokine, its role in gestational diabetes mellitus (GDM) is currently unknown. We aimed to evaluate serum vaspin levels and their correlation with insulin resistance in women with and without GDM. Forty-four women with GDM [GDM Group - 20 managed with diet only (GDM-diet) and 24 with diet plus insulin (GDM-insulin)] and 44 age-matched pregnant women with normal glucose tolerance (Control Group) were studied. Serum glucose, lipids, uric acid, insulin and vaspin were measured at the 2nd and 3rd trimester of pregnancy and postpartum. The quantitative insulin sensitivity check index (QUICKI) and homeostasis model of assessment-insulin resistance (HOMA-IR) were calculated. Circulating vaspin levels decreased significantly postpartum in all groups (p

Published
2012

56. Lipid profile, low-density lipoprotein oxidation and ceruloplasmin in the progeny of families with a positive history of cardiovascular diseases and/or hyperlipidemia

Author

Dimitri P. Mikhailidis, Georgios Papageorgiou, Areti Makedou, Anargyros Kourtis, Kali Makedou, Norma Vavatsi-Christaki, and Stavros Iliadis

Subjects
medicine.medical_specialty, Apolipoprotein B, Adolescent, Blood lipids, Hyperlipidemias, Lipid peroxidation, chemistry.chemical_compound, Young Adult, Internal medicine, Malondialdehyde, Hyperlipidemia, medicine, Humans, Genetic Predisposition to Disease, Child, biology, medicine.diagnostic_test, Greece, business.industry, Cholesterol, Ceruloplasmin, Cholesterol, LDL, medicine.disease, Lipids, Pedigree, Lipoproteins, LDL, Endocrinology, chemistry, Cardiovascular Diseases, Low-density lipoprotein, Case-Control Studies, Apolipoprotein B-100, biology.protein, lipids (amino acids, peptides, and proteins), Lipid Peroxidation, Cardiology and Cardiovascular Medicine, business, Lipid profile, Biomarkers, Lipoprotein
Abstract

Fifty-eight healthy progeny (mean age ± SD 13.9 ± 7.9 years) of 39 families with a positive history for Cardiovascular Diseases ([CVD] n = 44) or hyperlipidemia (n = 14) were included in the study and were compared with 30 age-matched control participants, with a negative family history, to evaluate lipid profile, ceruloplasmin (Cp), and lipid peroxidation product (malondialdehyde [MDA]) levels, as well as in vitro copper-induced Low-density lipoprotein (LDL) oxidizability. Mean serum levels of total cholesterol, LDL cholesterol (LDL-C), apolipoprotein B-100, and MDA of the participants were significantly higher than those of the controls. Lag time, an LDL resistance oxidation marker, was lower in the study group and negatively correlated with LDL-C ( r = -.437, P < .05) and Cp ( r = -.272, P < .05) serum levels. In conclusion, progeny with a positive family history for CVD or hyperlipidemia have an atherogenic lipid profile and increased LDL susceptibility to oxidation. High Cp levels seem to be related to lower resistance of LDL to oxidation.

Published
2009

57. Lipid profile of children with a family history of coronary heart disease or hyperlipidemia: 9-year experience of an outpatient clinic for the prevention of cardiovascular diseases

Author

George Varlamis, Areti Makedou, Maria Kourti, Kali Makedou, and Sofia Lazaridou

Subjects
Male, medicine.medical_specialty, Apolipoprotein B, Adolescent, Arteriosclerosis, Coronary Disease, Hyperlipidemias, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Reference Values, Risk Factors, Internal medicine, Hyperlipidemia, medicine, Ambulatory Care, Outpatient clinic, Humans, 030212 general & internal medicine, Family history, Child, Triglycerides, biology, medicine.diagnostic_test, business.industry, medicine.disease, Lipids, Endocrinology, Cardiovascular Diseases, Child, Preschool, biology.protein, lipids (amino acids, peptides, and proteins), Apolipoprotein A1, Female, Cardiology and Cardiovascular Medicine, Lipid profile, business, Dyslipidemia
Abstract

The authors evaluated the lipid profile of children with a positive family history of coronary heart disease (CHD), cerebrovascular disease (CVD), or hyperlipidemia and compared them with controls in order to identify risk indicators for atherosclerosis. A group of 315 children (group A) aged more than 2 years old with a positive family history were evaluated for serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), highdensity lipoprotein cholesterol (HDL-C), triglycerides (TG), apolipoprotein B100 (ApoB100), apolipoprotein A1 (Apo A1), and lipoprotein (a) (Lp[a]). These values were compared with the levels of a control group of 214 children of comparable age (group B). The median age of children in groups A and B was 10.6 (range 2.3-16) and 9.8 (range 3-13.7) years of age, respectively. Among these children, 196 (52%), 47 (12.5%), and 72 (19.1%) had a positive family history of CHD (group A1), cerebrovascular disease (CVD) (group A2), and hypercholesterolemia (group A3), respectively. We identified 8 children with genetically determined dyslipidemia: 2 children with homozygous and 6 with heterozygous familial hypercholesterolemia. Children in group A3 had significantly higher concentrations of TC, TG, LDL-C, and ApoB100 and lower concentrations of Apo A1 compared with controls, while no significant differences were found in concentrations of lipid variables among children of group A1, A2, and A3. Significant differences were also noted in the concentrations of TC, LDL-C, and Lp(a) between children of group A1 and controls. Screening the progeny of young patients with CHD or familial hypercholesterolemia can identify children at excessive risk for future vascular disease.

Published
2005

58. Changes in antibiotic resistance of the most common Gram-negative bacteria isolated in intensive care units

Author

A.A. Halvantzis, A.G. Bisiklis, Maria Chatzidimitriou, E.P. Tsiakiri, S. Alexiou-Daniel, Kali Makedou, and K. Ntoutsou

Subjects
Microbiology (medical), Imipenem, Ceftazidime, Microbial Sensitivity Tests, Tazobactam, Microbiology, Intensive care, Drug Resistance, Bacterial, medicine, Tobramycin, Humans, Acinetobacter calcoaceticus, biology, Greece, business.industry, General Medicine, Acinetobacter, biology.organism_classification, Anti-Bacterial Agents, Intensive Care Units, Klebsiella pneumoniae, Infectious Diseases, Amikacin, Pseudomonas aeruginosa, business, medicine.drug, Piperacillin
Abstract

We studied the changes in antibiotic resistance of the most common Gram-negative bacteria isolated in the intensive care units at our hospital in 2000 and 2002. Bacterial identification was performed by use of the VITEK 60 analyser, and antibiotic susceptibilities were tested by the VITEK 60 analyser and the disk diffusion agar method. The bacteria isolated most frequently were Pseudomonas aeruginosa (132 strains in 2000 and 106 in 2002), Acinetobacter calcoaceticus (98 and 109 strains, respectively) and Klebsiella pneumoniae (53 and 83 strains, respectively). Acinetobacters presented the highest percentage resistance, with significant increases in resistance to imipenem (15% in 2000 and 67% in 2002) and piperacillin/tazobactam (41% and 72%, respectively). P. aeruginosa presented a significant increase in resistance to all antibiotics, except ceftazidime. A large increase was observed in the resistance of K. pneumoniae to amikacin (from 10% to 50%), ceftazidime (from 80% to 90%) and tobramycin (from 80% to 90%). No imipenem-resistant strains of K. pneumoniae were found.

Published
2004

59. Corrigendum to 'Biomarkers of endothelial dysfunction in preeclampsia and neonatal morbidity: A case-control study' [Eur. J. Obstet. Gynecol. Reprod. Biol. 175 (2014) 119–123]

Author

Apostolos Athanasiadis, Spyros Gerou, Ioannis Kalogiannidis, Katerina Koiou, Kali Makedou, Theodoros Theodoridis, Theodoros Agorastos, and S Masoura

Subjects
Gynecology, Neonatal morbidity, medicine.medical_specialty, Reproductive Medicine, business.industry, medicine, Case-control study, Obstetrics and Gynecology, Endothelial dysfunction, medicine.disease, business, Preeclampsia
Published
2014
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60. Consultants for the American Journal of Nephrology 2007

Author

Robert J. Schotzinger, Shou-Shang Chiang, Yingjie Liang, Tun-Jun Tsai, Janet B. McGill, Masayo Aizawa, Hsueh-Fang Chuang, Areti Makedou, L. Ferder, Jun Miyoshi, F. Inserra, Colin E. Murdoch, Katsunori Sawada, Shigeo Yamamoto, Kimihiko Yanase, Chih-Ching Yang, Mark E. Williams, Eiji Kawasaki, Ariela Benigni, Rajiv Agarwal, Niansheng Yang, Carla Zoja, Fabio Sangalli, Kuan-Yu Hung, Rintarou Moriguchi, Flavio Gaspari, Katsumi Eguchi, Raja G. Khalifah, M. Ferder, Pavlos Malindretos, Masaaki Izumi, Fabiola Carrara, Min Zhang, Daniela Corna, Mingqian Luo, Tsuyoshi Tanimoto, Chwei-Shiun Yang, Yu-Sen Peng, Yukiko Hasuike, Alex Sirker, W. Kline Bolton, Takeshi Nakanishi, Ajay M. Shah, Yoshimi Takai, Kouji Miyagawa, Kali Makedou, Kei Maki, Dario Cattaneo, Thorsten P. Degenhardt, Chun-Fu Lai, Yuefang Huang, Diego Brancaccio, Vasilios Raptis, Mario Cozzolino, Toshiji Iwasaka, Maurizio Gallieni, Pantelis Sarafidis, Giuseppe Remuzzi, Gian Vico Melzi d’Eril, Reiko Hata, Andrea Remuzzi, Maria Luisa Biondi, Yih-Ron Lien, Kunihiro Ichinose, Ming-Shiou Wu, Chung-Hsin Chang, Xueqing Yu, Takahiro Kuragano, Andrea Galassi, Dimirios M. Grekas, Rong Li, Igor Rudenco, Satoshi Morimoto, Ching-Jyh Shiah, Norberto Perico, Kwan-Dun Wu, Rui Zhang, Chia-Sheng Lu, Yu-Ting Wang, E.M.V. de Cavanagh, Fang Wang, Lili Zhang, Wang-Yu Chen, and Yutaka Yano

Subjects
Nephrology, medicine.medical_specialty, business.industry, Internal medicine, Family medicine, medicine, business
Published
2007
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61. Subject Index Vol. 27, 2007

Author

Mark E. Williams, Chwei-Shiun Yang, Kuan-Yu Hung, Areti Makedou, L. Ferder, Igor Rudenco, Kimihiko Yanase, M. Ferder, Satoshi Morimoto, Daniela Corna, Rajiv Agarwal, Kali Makedou, Janet B. McGill, Masayo Aizawa, Katsumi Eguchi, F. Inserra, Katsunori Sawada, Colin E. Murdoch, Yukiko Hasuike, Pantelis Sarafidis, Giuseppe Remuzzi, Chun-Fu Lai, Andrea Remuzzi, Fabio Sangalli, Kunihiro Ichinose, Thorsten P. Degenhardt, Toshiji Iwasaka, Eiji Kawasaki, Takahiro Kuragano, Dario Cattaneo, Ariela Benigni, Kei Maki, Hsueh-Fang Chuang, Shigeo Yamamoto, Rong Li, Vasilios Raptis, Fabiola Carrara, Gian Vico Melzi d’Eril, Ching-Jyh Shiah, Norberto Perico, Yuefang Huang, Maurizio Gallieni, Robert J. Schotzinger, Chung-Hsin Chang, Kwan-Dun Wu, Yih-Ron Lien, Flavio Gaspari, Chia-Sheng Lu, Fang Wang, Xueqing Yu, Ming-Shiou Wu, Min Zhang, Tun-Jun Tsai, Reiko Hata, Dimirios M. Grekas, Lili Zhang, Yingjie Liang, W. Kline Bolton, Yoshimi Takai, Shou-Shang Chiang, Pavlos Malindretos, Takeshi Nakanishi, Niansheng Yang, Rintarou Moriguchi, Yu-Sen Peng, Andrea Galassi, Ajay M. Shah, Maria Luisa Biondi, Raja G. Khalifah, Yutaka Yano, Alex Sirker, E.M.V. de Cavanagh, Jun Miyoshi, Kouji Miyagawa, Wang-Yu Chen, Mario Cozzolino, Chih-Ching Yang, Tsuyoshi Tanimoto, Carla Zoja, Rui Zhang, Yu-Ting Wang, Masaaki Izumi, Diego Brancaccio, and Mingqian Luo

Subjects
Index (economics), Nephrology, business.industry, Statistics, Medicine, Subject (documents), business
Published
2007
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63. Lab methods, progression & risk factors for CKD - 2

Author

Athanasios Sioulis, Xiao Li, N. P. Singh, Morten Grundtvig, Maximilian Nerlander, Leon Schuster, Yingyos Avihingsanon, Marek Kretowicz, Jan A. Krikken, Raymed Bacallao Méndez, Svetlana Semina, Minoru Ando, Isabel Millán, Edson de Andrade Pessoa, T. Johnson, Sathit Kurathong, Ana Luiza Ribeiro Bard De Carvalho, Benedita C. Novaes, Suzon Collette, Vasilios Raptis, Tao Su, Grażyna Goszka, Giusy Chiarelli, Yuko Kikuchi, Richard J. Johnson, Fabiola Martin del Campo, Adolfo Reyes, Hitoshi Minakuchi, Carlos Culebras, Cesar Garcia-Cantón, Leonardo Cabrera, Visnja Lezaic, Reynaldo Mañalich, Omar R. Santos, Robert Ekart, Michel White, Barbara Brancati, Sudheer Sankar, Giacomina Loriga, Maria Helena Victor, Giovanna Farre, Gianina Gabriela Sotila, Ken-ichi Koga, James E. Sharman, Cesar González, Alfonso M. Cueto-Manzano, Keiko Sueyasu, L. Barsan, Xavier Barber, Reem Al-Jayyousi, Abdul Abdellatif, Mitsuteru Koizumi, Gordana Perunicic-Pekovic, Radovan Hojs, Ana Esther Sirvent, Agustin Toledo, Tatiana Piminova, Giuseppe Remuzzi, Yi-Mei Hong, Masayuki Kanazawa, Ahmed El-Ghandor, Elena Shachnova, K. van der Putten, Minghui Zhao, Yasuhiro Komatsu, Elena Platova, Dimitrios Grekas, Yusuke Watanabe, Osamu Ito, Cheri Hotu, Natavudh Townamchai, Linda Lim, Oran Chalapipat, Yana Reznik, Stergios Kapoulas, Norberto Perico, Gerjan Navis, Femke Waanders, Koichi Hayashi, Yong Gu, Nan Chen, Francesca Borghetti, Francisco Amorós, Maksimiljan Gorenjak, Minmin Zhang, Zhaohui Wang, Tawatchai Chawatanarat, Kali Makedou, Aphrodite Avdelidou, Raka Widiana, Martin Shearer, Nestor Schor, Mikhail Likstanov, Kazuhiro Kobayashi, Yipu Chen, Susan Ordaz, Robert G. Fassett, Peng-yu Cao, A. Stanciu, Ying Qian, Bert Dikkeschei, Fumika Taki, Hiroshi Itoh, Paul E. de Jong, Kazuhiro Hasegawa, Jing Chen, Mathias Alexandre Volkmann, La-or Chailurkit, Kanika Kalra, Wei-Song Qin, Nynke Halbesma, Naofumi Ikeda, Kearkiat Praditpornsilpa, Hong Wei, Khajohn Tiranathanagul, Sue Carr, B.C. Koch, Ludvik Puklavec, Mhairi K. Sigrist, Helene Lord, J. Ibrini, C.A. Gaillard, Ljubica Djukanovic, Alexandria Romann, Stephan J. L. Bakker, Mark Reinhard, Hong Zhang, A. M. El Nahas, Maarten W. Taal, Qiaolin Sun, Luiz Paulo José Marques, Yuji Nishizaki, Adelina Mihaescu, Constanza Glücksman, Larisa Belyaeva, Jonathan Gelfond, Domonic Harrington, Marcia Bastos Convento, Li Zhu, Emma L. Clapp, John Feehally, Jamal El-Kheshen, Joao R.M. Santanna, Liffert Vogt, Vera Kushnir, Alastair Ferraro, Mercedes Mitjavila, J.E. Nagtegaal, Hector Martinez, Catherine Weber, Ivo A. Nesralla, Akihiko Suganuma, Gurmeen Kaur, Kieren Voong, Hirofumi Tokuyama, Liudmila Chesnokova, Shoko Ohno, Ricardo Enríquez, Gema Fernandez Juarez, Masahiro Kohzuki, Liliana Tuta, Takahiko Sato, Lynne Senécal, Zhao-Hong Chen, Guy B. Pelletier, Juan Jose Gorgojo, Dominic P. Geraghty, Esther Meijer, Shinichi Watanabe, Laura Sottini, Yoshikazu Muroya, Dolores Checa, Caroline B. Scorsato, Sebastjan Bevc, Normand Racine, Luciana Scalone, Liz Lightstone, G.S. Toteja, Yu Wu, Vicente Barrio, Tomohiro Kikuta, Warwick Bagg, Giovanni Cancarini, J.P. Wielders, Graham Lipkin, Li You, Ketut Suwitra, Ryoko Kasori, Chinatsu Okamoto, Mar Lago, Alketa Koroshi, Daisuke Ito, Geesje Dallinga-Thie, N. Brunskill, Boris Bikbov, Jyunji Tanaka, E.J.W. van Someren, A. Sburlan, Pisut Katawatin, Nada Dimkovic, Alexander Salmayer, Geeta Hampson, Erland J. Erlandsen, Danica Bukvic, Benereta Hoxha, Kim Sinammon, Hongliang Rui, Naoki Washida, Francisco Javier Fernández, Lorenzo Mantovani, Areti Hitoglou-Makedou, Adrian Zugravu, John F. Collins, XiaoMei Li, Anne Boucher, Shanyan Lin, Yoshikazu Hara, Koichi Seta, Satoru Tatematsu, Iain K Robertson, Kyoko Yoshioka, Masahiro Tsuda, Akira Sugawara, Else Randers, Richard Fluck, Thananda Trakarnvanich, Yusuke Tsugawa, Jodi Loekman, Simona Stancu, David Goldsmith, Lars Gullestad, Matthew Hall, Karen Tullett, Eito Kozawa, Rafael Fuentes, Geoff Braatvedt, D. Dumitru, Yi-Zhou Lu, Laura Cortes, Mariève Cossette, Talerngsak Kanjanabuch, João L. Viana, Nicolette C. Bishop, Flavio Gaspari, Lei-Shi Li, Kriang Tungsanga, George Kosmadakis, Wajeh Y. Qunibi, Etleva Emrullai, Bastianina Scanu, Sinee Disthabanchong, Andrea Satta, María E. Vázquez, Adeera Levin, Yuki Kaneshiro, Kensei Yahata, Natasha J. McIntyre, Kenta Takashima, Robin P. F. Dullaart, Sanja Bajcetic, P.M. ter Wee, Renato A.K. Kalil, Natalya Kozlovskaya, Nestor Thereska, Shaojun Liu, Carolina Batis, Chuanming Hao, Ruth da Silvera, Madeleine J. Ball, Julián García, Estela Noguiera, Arne Westheim, Wasana Stitchantrakul, Regina Rocco, Keiichi Tamagaki, R.S. Chana, Paulo Roberto Cardoso Consoni, Nigel J. Brunskill, Somchai Eiam-Ong, Elena Corchete, Jiong Zhang, Naoki Yanagisawa, Torstein Hole, Vladimir Sadovnikov, Miyuki Futatsuyama, Alice C. Smith, Manuela Sanna, Greg D. Gamble, Anupam Prakash, Atsushi Ajisawa, Wen Zhang, Padmini Manghat, Michel Carrier, M. Lipan, Jonde Arai, Jeff S. Coombes, Pavlos Mallindretos, Kosaku Nitta, Caihong Zeng, Pilar Rossique, Ron T. Gansevoort, Ramses Miotto, Javiel Cubas, Tsutomu Inoue, Ana Ramirez, Elisabetta Pisanu, Jacek Manitius, Jayme Eduardo Burmeister, Alan Bevington, Battista Fabio Viola, Ingrid Auyanet, Raymond Dandavino, Tatyna Kirsanova, Paulo R. Prates, Gabriel Mircescu, Jiaxiang Ding, Christopher W. McIntyre, Baard Waldum, Rita Gerra, Akifumi Imamura, Oksana Lutsenko, Fernanda Borges, Ken Tsuchiya, Zhihong Liu, Elvira Bosch, Abdel-Bassit El Shaarawy, Andres Cadena, Hiromichi Suzuki, Joachim Struck, S. Darwish, Paulo E. Behr, Xiaojie Lin, Shu Wakino, Giuliano Brunori, and Ingrid Os

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, medicine, Intensive care medicine, business
Published
2009
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64. Bone disease - 2

Author

Ebru Sevinc, Cheryl Arko, J. Prado Rome, Ercan Ok, Joan Casellas, Marc Benhamou, F. Perretta, Ananda Sen, D. Verbeelen, Mary B. Leonard, Benyounes Ramdani, B. Benavides, M. Farh, Piergiorgio Messa, Svetlana Ignjatovic, Dimitrios Grekas, Paulina Dumnicka, Andreas Margioris, Vasilios Zafiropulos, Tatsuya Shoji, David Ansell, Stergios Kapoulas, Giuseppe Cannella, P.Y. Martin, Jing-fang Zhao, Vanda Jorgetti, M. Norbi, Mohamed Zamd, D. Andress, Lucila Maria Valente, F. Riad, Robert Rakowski, Hiroaki Ogata, Erika Aguilar, F.J. Ariza, Lenicio Andrade Filho, Fumihiko Koiwa, Fabiana G. Graciolli, Nathan W. Levin, Władysław Sułowicz, Feyza Sen, Susan C. Schiavi, R.L. Pisoni, Juergen Floege, Eugene Daphnis, C. Sagliker, W. Kleophas, M. Ferrero, Aureli Machado, D.S. Fuller, A. Citarelli, Takuya Uehata, Akihiro Shimomura, Jochen G. Raimann, H. Ben Maiz, R. Wilberg, Ekaterini Michalaki, M. Esenturk, S.H. Jacobson, Eriko Kinugasa, Hua Zhou, Alaa Sabry, A. Lafalla, Maria Luisa Muci, M. El Khasmi, Sonya Steppan, Katia R. Neves, A. Aralde, S. Fishbane, Renato C. Monteiro, Bruce M. Robinson, E.W. Young, G. Gomez, Andrea O. Magalhães, Aphrodite Avdelidou, Jose Maria Cruzado, Tadao Akizawa, Yoko Nishikawa, Tamara Jemcov, Analuzia Medeiros, David Goldsmith, Svetlana Pejanovic, David Fuster, Monika Krasnicka, Christopher T. Chan, Jelena Marinkovic, Marie-Claude Monier-Faugere, Shigeru Nakai, Liliana Gonzalez, Takayuki Hamano, W. Douthat, Siddik Momin Adam, Franco Citterio, Geoffrey Block, Antonio R. Gargiulo, D. Grbavac, Selda Sarikaya, Rosa M.A. Moysés, R. Cutrona, Joanne M. Bargman, Benjamín Gómez, Mario Cozzolino, Sherry Liu, Madiha Ez-Zahidy, Y. Maccio, Adrian Covic, Tetsuya Kaneko, J M Campistol, Mümtaz Yilmaz, F. De Rosa, Visnja Lezaic, Kimberly Nieman, O. Demirhan, J.V. Torregrosa, J. Bommer, O. Golea, F.D. Tentori, Elizabeth Shane, David M.J. Naimark, Ivan Gamez, John L. Griffith, L. Zarate, Takuma Hazama, Marzia Pasquali, Peter Kotanko, Srinivas Hariachar, Verônica Gouveia, Marijana Dajak, Thomas L. Nickolas, Miguel Medina, F. Gotch, Areti Hitoglou-Makedou, M. Pudu, Lidija Orlić, N. Paylar, Adriana Penalba, Assia Lahboub, C. Hsu Chen, David Zaun, X. Edward Guo, Takuo Kusumoto, W.J. Bos, Takashi Shigematsu, M. Lludgard, V. Altobelli, Dakshina Jayasena, Hartmut H. Malluche, J. Ziella, Sandra Neiva Coelho, Eyup Kulah, Marek Kuzniewski, G. Rosa Diez, Manasi Desai, Irene Katsipi, Duygu Yoruk, P.S. Ozkaynak, Mehmet Ozkahya, James Onwubalili, K. Eyupoglu, Steven Fishbane, Noriyuki Okada, J. Nagy, Fabiola Martin del Campo, H. Moretto, Fatih Kircelli, Gulay Asci, Peter J. Dupont, Martin Wagner, Kali Makedou, J.L. Fernandez-Martin, Anastasia Markaki, José Edevanilson de Barros Gueiros, Navdeep Tangri, Sylvie Schwarzova, F. Chavez, D. Pavlovic, Rolina Natso, Thomas Oates, Jose-Vicente Torregrosa, Chiaki Kumata-Maeta, Sandro Mazzaferro, G. Ibanez, F. Tornero, Irene Dermitzaki, Marisa Battistella, A. Hansen, C. Mascheroni, Geoff A. Block, A. Marcozzi, Carolina Batis, A. Kruse, Robert M. Richardson, Pavlos Mallindretos, Giusy Mandanici, Seiya Okuda, R. Kramar, Dimitrios Memmos, Bin Sun, Fumiko Kondo, Ana Paula Santana Gueiros, V. Bhalani, Athanasios Sioulis, Y. Sagliker, G. Aguirre, Francesco Pugliese, Patrik Letocha, Raffaella Lavini, Daniella G. Batista, Mohamed Gharbi Benghanem, Osamu Tamai, Jorge B. Cannata-Andía, Jana Smrzova, Marie Marsova, M. Ketteler, Diego Brancaccio, M. Sipahioglu, Yusuke Sakaguchi, Vidosava Nesic, Giuliana Pirrò, J. Bover, Sharon M. Moe, M. Molina, Jiannong Liu, Naoufal Mtioui, Beata Kusnierz-Cabala, L. Garneata, S. Setti, Huseyin Toz, R. Pérez García, R.P. Wüthrich, Jeremy Heaton, I. Yildiz, Nurcan Kara, J.L. Gorriz, Elisavet Pouliou, Changying Xing, Hiromi Irishio, C. Najun, Luciene M. dos Reis, A. Ferreira, Franco Locatelli, Zeljka Crncevic, Stephan Thijssen, H. Lopez, Takashi Akiba, P. Audhya, Ahmet Dursun, E.H. Tahri, V. Acharya, Kostas Stylianou, L. Urtiaga, Wadi N. Suki, Alexandra Hodsman, Mehmet Cabuk, Gérard M. London, Kostas Perakis, L. Leon, I. Emir, Vladimír Teplan, Melani Ribeiro Custódio, Wendy L. St. Peter, Gloria Martin, R. Giachi, Danuta Fedak, Jutta Passlick-Deetjen, Yoshiharu Tsubakihara, Milan Radovic, D. Redulescu, M. Benedik, C. Mengarelli, D. Ookalkar, Stuart M. Sprague, Masahide Mizobuchi, A. Alles, B. Rutkowski, James A. Delmez, A. Lara, N. El Abbadi, E. Hernandez, C. Scifo, Tomáš Urbánek, H. Sagliker, Carmina Conte, L. Zhang, Milous Vyskocil, C. Tielemans, Alfonso M. Cueto-Manzano, E. Dhole, Masahisa Fujisawa, J.L. Miguel Alonso, Rita Martim, and E. Del Valle

Subjects
03 medical and health sciences, Transplantation, Pathology, medicine.medical_specialty, 0302 clinical medicine, Bone disease, Nephrology, business.industry, 030232 urology & nephrology, medicine, medicine.disease, business
Published
2009
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65. Contents Vol. 27, 2007

Author

Eiji Kawasaki, Ariela Benigni, Rui Zhang, Takeshi Nakanishi, Yu-Ting Wang, Reiko Hata, Yuefang Huang, Kuan-Yu Hung, Fabiola Carrara, Andrea Galassi, Yingjie Liang, Flavio Gaspari, Toshiji Iwasaka, Chun-Fu Lai, Tun-Jun Tsai, M. Ferder, Chia-Sheng Lu, Fang Wang, Kei Maki, Dario Cattaneo, Ming-Shiou Wu, Yukiko Hasuike, Shou-Shang Chiang, E.M.V. de Cavanagh, Jun Miyoshi, Kouji Miyagawa, Mingqian Luo, Igor Rudenco, Min Zhang, Thorsten P. Degenhardt, Lili Zhang, Satoshi Morimoto, Pantelis Sarafidis, Masaaki Izumi, Pavlos Malindretos, Mario Cozzolino, Niansheng Yang, Yih-Ron Lien, Vasilios Raptis, Giuseppe Remuzzi, Maria Luisa Biondi, Xueqing Yu, Daniela Corna, F. Inserra, Tsuyoshi Tanimoto, W. Kline Bolton, Andrea Remuzzi, Colin E. Murdoch, Dimirios M. Grekas, Maurizio Gallieni, Chwei-Shiun Yang, Rintarou Moriguchi, Yoshimi Takai, Ching-Jyh Shiah, Norberto Perico, Yu-Sen Peng, Raja G. Khalifah, Kunihiro Ichinose, Ajay M. Shah, Fabio Sangalli, Takahiro Kuragano, Kwan-Dun Wu, Rong Li, Hsueh-Fang Chuang, Kali Makedou, Areti Makedou, L. Ferder, Kimihiko Yanase, Gian Vico Melzi d’Eril, Alex Sirker, Rajiv Agarwal, Diego Brancaccio, Katsumi Eguchi, Wang-Yu Chen, Mark E. Williams, Chung-Hsin Chang, Yutaka Yano, Shigeo Yamamoto, Chih-Ching Yang, Carla Zoja, Janet B. McGill, Masayo Aizawa, Katsunori Sawada, and Robert J. Schotzinger

Subjects
Traditional medicine, Nephrology, business.industry, Medicine, business
Published
2007
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66. Association of ceruloplasmin serum levels with LDL oxidation in progeny of families with history of cardiovascular diseases or hyperlipidemia

Author

Stavros Iliadis, Kali Makedou, Anargyros Kourtis, George Z. Papageorgiou, Norma Vavatsi-Christaki, Areti Makedou, and A Dimitriadou

Subjects
medicine.medical_specialty, Endocrinology, Epidemiology, business.industry, Internal medicine, Hyperlipidemia, medicine, Ceruloplasmin - serum, Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2006
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67. Rosiglitazone lowers C-reactive protein levels in hypertensive type 2 diabetic patients

Author

Pantelis Zebekakis, Athanasios Diamantopoulos, Kali Makedou-Kourti, Panagiotis C. Stafilas, Achilleas A. Tourkantonis, Anastasios N. Lasaridis, and P. Sarafidis

Subjects
medicine.medical_specialty, biology, Glucose control, business.industry, medicine.drug_class, C-reactive protein, Endocrinology, Internal medicine, Internal Medicine, medicine, biology.protein, Thiazolidinedione, C-reactive protein measurement, business, Rosiglitazone, medicine.drug
Published
2005
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68. Lipid profile in women with polycystic ovary syndrome and normal BMI

Author

Anargyros Kourtis, Kali Makedou, David Rousso, G. Vlassis, Dimitrios Panidis, and V. Panoussis

Subjects
Gynecology, medicine.medical_specialty, Obstetrics and gynaecology, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Medicine, General Medicine, Normal BMI, business, Lipid profile, Polycystic ovary
Published
2000
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69. Helicobacter Pylori and angiographically documented coronary artery disease

Author

D. Katriou, Georgios E. Louridas, Anargyros Kourtis, Kali Makedou, T. Farmakis, Amalia Boufidou, G. Gourasas, O. Martou, K. Broghistinos, and Areti Makedou

Subjects
Coronary artery disease, medicine.medical_specialty, biology, business.industry, Internal medicine, medicine, Helicobacter pylori, Cardiology and Cardiovascular Medicine, biology.organism_classification, medicine.disease, business, Gastroenterology
Published
1999
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70. Cytomegalovirus (CMV) and angiographically documented coronary artery disease

Author

Kali Makedou, K. Vroghistinos, Georgios E. Louridas, T. Farmakis, Amalia Boufidou, D. Katriou, Stavros Hadjimiltiades, Areti Makedou, and Anargyros Kourtis

Subjects
Coronary artery disease, medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, Congenital cytomegalovirus infection, Cardiology and Cardiovascular Medicine, business, medicine.disease
Published
1999
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71. The involvement of uric acid in the pathogenesis of preeclampsia

Author

Theodoros Theodoridis, S Masoura, Leonidas Zepiridis, Anargyros Kourtis, Kali Makedou, and Apostolos Athanasiadis

Subjects
medicine.medical_specialty, Hyperuricemia, Disease, urologic and male genital diseases, Preeclampsia, Pathogenesis, chemistry.chemical_compound, Pre-Eclampsia, Pregnancy, Internal medicine, Internal Medicine, medicine, Humans, reproductive and urinary physiology, Fetus, business.industry, Pregnancy Outcome, medicine.disease, female genital diseases and pregnancy complications, Uric Acid, Endocrinology, chemistry, embryonic structures, Uric acid, Gestation, Female, business
Abstract

Preeclampsia is a common disorder of human pregnancy and a major cause of worldwide pregnancy-related maternal and neonatal morbidity and mortality. Oxidative stress, angiogenic imbalance, placental ischemia and an inflammatory response have been proposed to play role in the pathogenesis of the disease. Hyperuricemia is a key biochemical feature in preeclampsia with elevated levels of uric acid being diagnosed as early as the 10(th) week of gestation. Traditionally, elevated uric acid levels were considered a result of renal dysfunction known to exist in preeclampsia. The contribution of uric acid in the pathogenesis of preeclampsia is being recently further investigated. We, hereby, review the possible mechanisms by which uric acid contributes to the development of the disease and its complications both on mother and fetus.

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