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62. Abstracts Of Contributed Papers — National Plant Pathology Conference, Sydney, May 1974

Author

Arentz, F., Heather, W. A., Pratt, B. H., Burnbieris, M., Marks, G. C., Kassaby, F. Y., Pratt, B. H., Shepherd, C. J., Heather, W. A., Taylor, P. A., Pratt, B. H., Heather, W. A., shepherd, C. J., Bertus, A. L., Walker, J., Chou, C. K. S., Marks, G. C., Minko, G., Chou, C. K. S., van Kraayenoord, C. W. S., Hartigan, D. T., Alcorn, J. L., Mayfield, A. H., Clare, B. G., Dube, A. J., Wildermuth, G. B., Rees, R. G., Keogh, R., Sanderson, F. R., Blackstock, J. M., Ikegami, M., Francki, R. I. B., Moghal, S. M., Francki, R. I. B., Price, R. D., Blackstock, J., McGechan, J. K., Bowyer, J. W., Gibbs, A. J., Skotnicki, A., Brown, R. H., Brown, R. H., Meagher, J. W., Brown, R. H., Davies, Kerrie A., Fisher, J. M., McLeod, R. W., Burnett, W. M., Goss, Olga M., Banyer, R. J., Colbran, R. C., McCulloch, Janet S., Htay, Khin, Roberts, W. P., Cother, E. J., Fahy, P. C., Lloyd, A. B., Shamsuddin, M. N., Praed, Joan, Moffett, Melda L., Allen, R. N., Biggs, D. R., Rezaian, M. A., Francki, R. I. B., Simpson, R. S., Scott, K. J., Walker, J., Burdon, J. J., Chilvers, G. A., Jenkins, P. T., Emmett, R., Pascoe, I., Kajornchaiyakul, P., Phon, C. J., Sanson, Martha, Weste, Greta, Parr-Smith, Pamela, Williams, P. G., Smith, A. M., Wildermuth, G. B., Kollmorgen, J. F., Wong, P., Kassaby, F. Y., Kile, G. A., Irwin, J. A. G., MacNish, G. C., Chin, J. C., Scott, K. J., Seviour, R. J., Chilvers, G. A., Gerrettson-Cornell, L., Whan, J. H., Muirhead, I. F., Blackstock, J. M., Sutton, J., Garrett, R. G., Sutton, J., Leggat, Frances W., Williams, P. F., O’Brien, P. C., Fisher, J. M., Brown, R. H., lnglis, I. M., Broadley, R. A., Broadley, R. A., Khair, G. T., McLeod, R. W., Sauer, M. R., Meagher, J. W., Clare, B. G., Shepherd, C. J., Totterdell, C. J., Stynes, B. A., Wallace, H. R., Arnold, J. R., Brown, J. F., Kochrnan, J. K., Siddiqui, M. Q., Rees, R. G., Kajornchaiyakul, P., Allen, S. J., McGee, D. C., McGee, D. C., Hartigan, D. T., Williams, P. F., Bamber, R. K., Delmas, Rosanne, and Dowden, H.

Published
1974
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66. Placenta-derived angiogenic proteins and their contribution to the pathogenesis of preeclampsia

Author

Pratt, A, Costa, FDS, Borg, AJ, Kalionis, B, Keogh, R, Murthi, P, Pratt, A, Costa, FDS, Borg, AJ, Kalionis, B, Keogh, R, and Murthi, P

Abstract

Placental angiogenesis is critical to the success of human pregnancy. Angiogenesis is defined as the formation of new blood vessels from existing vasculature. Angiogenesis is necessary for the establishment of adequate placental perfusion, which is important for providing the optimum in utero environment to support fetal development. Defective placental angiogenesis is associated with several pregnancy complications, the most clinically important of which is preeclampsia; the multisystem disorder is characterized by maternal hypertension, proteinuria, and endothelial dysfunction. Here, we review our current understanding of several key angiogenic factors that are associated with placental angiogenesis. We also discuss their importance with respect to preeclampsia, where aberrant expression and release of these factors into the maternal circulation is thought to contribute to the pathogenesis and pathophysiology of preeclampsia.

Published
2015

67. Genome-wide transcriptome directed pathway analysis of maternal pre-eclampsia susceptibility genes

Author

Yong, H., Melton, P., Johnson, M., Freed, K., Kalionis, B., Murthi, P., Brennecke, S., Keogh, R., Moses, Eric, Yong, H., Melton, P., Johnson, M., Freed, K., Kalionis, B., Murthi, P., Brennecke, S., Keogh, R., and Moses, Eric

Abstract

Background: Preeclampsia (PE) is a serious hypertensive pregnancy disorder with a significant genetic component. Numerous genetic studies, including our own, have yielded many susceptibility genes from distinct functional groups. Additionally, transcriptome profiling of tissues at the maternal-fetal interface has likewise yielded many differentially expressed genes. Often there is little overlap between these two approaches, although genes identified in both approaches are significantly associated with PE. We have thus taken a novel integrative bioinformatics approach of analysing pathways common to the susceptibility genes and the PE transcriptome. Methods: Using Illumina Human Ht12v4 and Wg6v3 BeadChips, transcriptome profiling was conducted on n = 65 normotensive and n = 60 PE decidua basalis tissues collected at delivery. The R software package libraries lumi and limma were used to preprocess transcript data for pathway analysis. Pathways were analysed and constructed using Pathway Studio. We examined ten candidate genes, which are from these functional groups: activin/inhibin signalling - ACVR1, ACVR1C, ACVR2A, INHA, INHBB; structural components - COL4A1, COL4A2 and M1 family aminopeptidases - ERAP1, ERAP2 and LNPEP.Results/Conclusion: Major common regulators/targets of these susceptibility genes identified were AGT, IFNG, IL6, INHBA, SERPINE1, TGFB1 and VEGFA. The top two categories of pathways associated with the susceptibility genes, which were significantly altered in the PE decidual transcriptome, were apoptosis and cell signaling (p < 0.001). Thus, susceptibility genes from distinct functional groups share similar downstream pathways through common regulators/targets, some of which are altered in PE. This study contributes to a better understanding of how susceptibility genes may interact in the development of PE. With this knowledge, more targeted functional analyses of PE susceptibility genes in these key pathways can be performed to examine their contr

Published
2015

70. Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity

Author

Yong, H., Murthi, P., Borg, A., Kalionis, B., Moses, Eric, Brennecke, S., Keogh, R., Yong, H., Murthi, P., Borg, A., Kalionis, B., Moses, Eric, Brennecke, S., and Keogh, R.

Abstract

Introduction: Pre-eclampsia (PE) has a familial association, with daughters of women who had PE during pregnancy having more than twice the risk of developing PE themselves. Through genome-wide linkage and genetic association studies in PE-affected families and large population samples, we previously identified the following as positional candidate maternal susceptibility genes for PE; ACVR1, INHA, INHBB, ERAP1, ERAP2, LNPEP, COL4A1 and COL4A2. The aims of this study were to determine mRNA expression levels of previously identified candidate maternal pre-eclampsia susceptibility genes from normotensive and severe PE (SPE) pregnancies and correlate mRNA expression levels with the clinical severity of SPE. Methods: Third trimester decidual tissues were collected from both normotensive (n = 21) and SPE pregnancies (n = 24) and mRNA expression levels were determined by real-time PCR. Gene expression was then correlated with several parameters of clinical severity in SPE. Statistical significance was determined by Mann–Whitney U test and Spearman's Correlation. Results: The data demonstrate significantly increased decidual mRNA expression levels of ACVR1, INHBB, ERAP1, ERAP2, LNPEP, COL4A1 and COL4A2 in SPE (p < 0.05). Increased mRNA expression levels of several genes – INHA, INHBB, COL4A1 and COL4A2 were correlated with earlier onset of PE and earlier delivery of the fetus (p < 0.05). Conclusion: These results suggest altered expression of maternal susceptibility genes may play roles in PE development and the course of disease severity.

Published
2014

72. Indigenous Health: ACTION on Prevention - 50th Annual Australian Society for Medical Research National Scientific Conference (Conference report)

Author

Yazbeck, Roger, Dawson, Paul, Rogers, N., West, C., Keogh, R., Wallace, Daniel, Polyak, Steven, Nowak, Kristen, Burton, Rachel A., Taylor, Juliet, Dunn, Louise, Philp, Amanda, Yazbeck, Roger, Dawson, Paul, Rogers, N., West, C., Keogh, R., Wallace, Daniel, Polyak, Steven, Nowak, Kristen, Burton, Rachel A., Taylor, Juliet, Dunn, Louise, and Philp, Amanda

Abstract

The 50th annual National Scientific Conference of the Australian Society for Medical Research was held in Cairns, Queensland, 13-16 November 2011. The theme, 'Indigenous Health: ACTION on Prevention' highlighted the direct action being undertaken by health and medical researchers, as well as allied health professionals, to improve long-term health outcomes for Indigenous Australians.

Published
2012

75. Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium

Author

Hutchinson, J, primary, Lentjes, M A H, additional, Greenwood, D C, additional, Burley, V J, additional, Cade, J E, additional, Cleghorn, C L, additional, Threapleton, D E, additional, Key, T J, additional, Cairns, B J, additional, Keogh, R H, additional, Dahm, C C, additional, Brunner, E J, additional, Shipley, M J, additional, Kuh, D, additional, Mishra, G, additional, Stephen, A M, additional, Bhaniani, A, additional, Borgulya, G, additional, and Khaw, K T, additional

Published
2011
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77. P2-118 Vitamin C intake from diary recordings and risk of breast cancer in the UK dietary cohort consortium

Author

Hutchinson, J., primary, Lentjes, M., additional, Greenwood, D., additional, Burley, V., additional, Cade, J., additional, Cleghorn, C., additional, Threapleton, D., additional, Key, T., additional, Cairns, B., additional, Keogh, R., additional, Dahm, C., additional, Brunner, E., additional, Shipley, M., additional, Kuh, D., additional, Mishra, G., additional, Stephen, A., additional, Bhaniani, A., additional, Borgulya, G., additional, Khaw, K. T., additional, and Rodwell, S., additional

Published
2011
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81. Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium

Author

Park, J Y, primary, Dahm, C C, additional, Keogh, R H, additional, Mitrou, P N, additional, Cairns, B J, additional, Greenwood, D C, additional, Spencer, E A, additional, Fentiman, I S, additional, Shipley, M J, additional, Brunner, E J, additional, Cade, J E, additional, Burley, V J, additional, Mishra, G D, additional, Kuh, D, additional, Stephen, A M, additional, White, I R, additional, Luben, R N, additional, Mulligan, A A, additional, Khaw, K-T, additional, and Rodwell, S A, additional

Published
2010
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82. Dietary Fiber and Colorectal Cancer Risk: A Nested Case-Control Study Using Food Diaries

Author

Dahm, C. C., primary, Keogh, R. H., additional, Spencer, E. A., additional, Greenwood, D. C., additional, Key, T. J., additional, Fentiman, I. S., additional, Shipley, M. J., additional, Brunner, E. J., additional, Cade, J. E., additional, Burley, V. J., additional, Mishra, G., additional, Stephen, A. M., additional, Kuh, D., additional, White, I. R., additional, Luben, R., additional, Lentjes, M. A. H., additional, Khaw, K. T., additional, and Rodwell (Bingham), S. A., additional

Published
2010
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98. Indigenous Health: ACTION on Prevention - 50th Annual Australian Society for Medical Research National Scientific Conference.

Author

Yazbeck, R., Dawson, P., Rogers, N., West, C., Keogh, R., Wallace, D., Polyak, S., Nowak, K., Burt, R., Taylor, J., Dunn, L., Philp, A., and Parkinson-Lawrence, E.

Abstract

The 50th annual National Scientific Conference of the Australian Society for Medical Research was held in Cairns, Queensland, 13-16 November 2011. The theme, 'Indigenous Health: ACTION on Prevention' highlighted the direct action being undertaken by health and medical researchers, as well as allied health professionals, to improve long-term health outcomes for Indigenous Australians. [ABSTRACT FROM AUTHOR]

Published
2012

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