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969 results on '"Kerbel, Robert S."'

51. Supplemental Methods from Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle–Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer

Author

Pham, Elizabeth, primary, Yin, Melissa, primary, Peters, Christian G., primary, Lee, Christina R., primary, Brown, Donna, primary, Xu, Ping, primary, Man, Shan, primary, Jayaraman, Lata, primary, Rohde, Ellen, primary, Chow, Annabelle, primary, Lazarus, Douglas, primary, Eliasof, Scott, primary, Foster, F. Stuart, primary, and Kerbel, Robert S., primary

Published
2023
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53. Supplementary Methods and Materials, Figure 1 from Vascular Endothelial Growth Factor–Mediated Decrease in Plasma Soluble Vascular Endothelial Growth Factor Receptor-2 Levels as a Surrogate Biomarker for Tumor Growth

Author

Ebos, John M.L., primary, Lee, Christina R., primary, Bogdanovic, Elena, primary, Alami, Jennifer, primary, Van Slyke, Paul, primary, Francia, Giulio, primary, Xu, Ping, primary, Mutsaers, Anthony J., primary, Dumont, Daniel J., primary, and Kerbel, Robert S., primary

Published
2023
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58. Supplementary Video 1a from Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia

Author

Franco, Marcela, primary, Man, Shan, primary, Chen, Limor, primary, Emmenegger, Urban, primary, Shaked, Yuval, primary, Cheung, Alison M., primary, Brown, Allison S., primary, Hicklin, Daniel J., primary, Foster, F. Stuart, primary, and Kerbel, Robert S., primary

Published
2023
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61. Data from Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents

Author

Shaked, Yuval, primary, Tang, Terence, primary, Woloszynek, Jill, primary, Daenen, Laura G., primary, Man, Shan, primary, Xu, Ping, primary, Cai, Shi-Rong, primary, Arbeit, Jeffrey M., primary, Voest, Emile E., primary, Chaplin, David J., primary, Smythe, Jon, primary, Harris, Adrian, primary, Nathan, Paul, primary, Judson, Ian, primary, Rustin, Gordon, primary, Bertolini, Francesco, primary, Link, Daniel C., primary, and Kerbel, Robert S., primary

Published
2023
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63. Data from Vascular Endothelial Growth Factor–Mediated Decrease in Plasma Soluble Vascular Endothelial Growth Factor Receptor-2 Levels as a Surrogate Biomarker for Tumor Growth

Author

Ebos, John M.L., primary, Lee, Christina R., primary, Bogdanovic, Elena, primary, Alami, Jennifer, primary, Van Slyke, Paul, primary, Francia, Giulio, primary, Xu, Ping, primary, Mutsaers, Anthony J., primary, Dumont, Daniel J., primary, and Kerbel, Robert S., primary

Published
2023
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68. Supplementary Results, Methods and Materials from Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

Author

Cruz-Muñoz, William, primary, Jaramillo, Maria L., primary, Man, Shan, primary, Xu, Ping, primary, Banville, Myriam, primary, Collins, Catherine, primary, Nantel, Andre, primary, Francia, Giulio, primary, Morgan, Sherif S., primary, Cranmer, Lee D., primary, O'Connor-McCourt, Maureen D., primary, and Kerbel, Robert S., primary

Published
2023
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71. Supplementary Figures 1-2 from Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents

Author

Shaked, Yuval, primary, Tang, Terence, primary, Woloszynek, Jill, primary, Daenen, Laura G., primary, Man, Shan, primary, Xu, Ping, primary, Cai, Shi-Rong, primary, Arbeit, Jeffrey M., primary, Voest, Emile E., primary, Chaplin, David J., primary, Smythe, Jon, primary, Harris, Adrian, primary, Nathan, Paul, primary, Judson, Ian, primary, Rustin, Gordon, primary, Bertolini, Francesco, primary, Link, Daniel C., primary, and Kerbel, Robert S., primary

Published
2023
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75. Supplementary Methods from Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents

Author

Shaked, Yuval, primary, Tang, Terence, primary, Woloszynek, Jill, primary, Daenen, Laura G., primary, Man, Shan, primary, Xu, Ping, primary, Cai, Shi-Rong, primary, Arbeit, Jeffrey M., primary, Voest, Emile E., primary, Chaplin, David J., primary, Smythe, Jon, primary, Harris, Adrian, primary, Nathan, Paul, primary, Judson, Ian, primary, Rustin, Gordon, primary, Bertolini, Francesco, primary, Link, Daniel C., primary, and Kerbel, Robert S., primary

Published
2023
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79. Supplementary Video Legend from Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia

Author

Franco, Marcela, primary, Man, Shan, primary, Chen, Limor, primary, Emmenegger, Urban, primary, Shaked, Yuval, primary, Cheung, Alison M., primary, Brown, Allison S., primary, Hicklin, Daniel J., primary, Foster, F. Stuart, primary, and Kerbel, Robert S., primary

Published
2023
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85. Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects

Author

Miller, Ian S., Khan, Sonja, Shiels, Liam P., Das, Sudipto, O'Farrell, Alice C., Connor, Kate, Lafferty, Adam, Moran, Bruce, Isella, Claudio, Loadman, Paul, Conroy, Emer, Cohrs, Susan, Schibli, Roger, Kerbel, Robert S., Gallagher, William M., Marangoni, Elisabetta, Bennett, Kathleen, O'Connor, Darran P., Dwyer, Róisín M., and Byrne, Annette T.

Subjects
Cancer prevention lymphangiogenesis, Breast cancer, Aspirin, Mouse model
Abstract

Backgorund: Prior data suggest pre-diagnostic aspirin use impacts breast tumour biology and patient outcome. Here, we employed faithful surgical resection models of HER2+ and triple-negative breast cancer (TNBC), to study outcome and response mechanisms across breast cancer subtypes. Method: NOD/SCID mice were implanted with HER2+ MDA-MB-231/LN/2-4/ H2N, trastuzumab-resistant HER2+ HCC1954 or a TNBC patient-derived xenograft (PDX). A daily low-dose aspirin regimen commenced until primary tumours reached ~250 mm3 and subsequently resected. MDA-MB-31/LN/2-4/H2N mice were monitored for metastasis utilising imaging. To interrogate the survival benefit of pre-treatment aspirin, 3weeks post-resection, HCC1954/TNBC animals received standard-of-care (SOC) chemotherapy for 6 weeks. Primary tumour response to aspirin was interrogated using immunohistochemistry. Results: Aspirin delayed time to metastasis in MDA-MB-231/LN/2-4/H2N xeno- grafts and decreased growth of HER2+/TNBC primary tumours. Lymphangiogenic factors and lymph vessels number were decreased in HER2+ tumours. However, no survival benefit was seen in aspirin pre-treated animals (HCC1954/TNBC) that further received adjuvant SOC, compared with animals treated with SOC alone. In an effort to study mechanisms responsible for the observed reduction in lymphangiogenesis in HER2+ BC we utilised an in vitro co-culture system of HCC1954 tumour cells and mesenchymal stromal cells (MSC). Aspirin abrogated the secretion of VEGF-C in MSCs and also decreased the lymph/angiogenic potential of the MSCs and HCC1954 by tubule formation assay. Furthermore, aspirin decreased the secretion of uPA in HCC1954 cells potentially diminishing its metastatic capability. Conclusion: Our data employing clinically relevant models demonstrate that aspirin alters breast tumour biology. However, aspirin may not represent a robust chemo-preventative agent in the HER2+ or TNBC setting., Cancer Medicine, 11 (20), ISSN:2045-7634

Published
2022

99. Vessel co‐option is common in human lung metastases and mediates resistance to anti‐angiogenic therapy in preclinical lung metastasis models

Author

Bridgeman, Victoria L, Vermeulen, Peter B, Foo, Shane, Bilecz, Agnes, Daley, Frances, Kostaras, Eleftherios, Nathan, Mark R, Wan, Elaine, Frentzas, Sophia, Schweiger, Thomas, Hegedus, Balazs, Hoetzenecker, Konrad, Renyi‐Vamos, Ferenc, Kuczynski, Elizabeth A, Vasudev, Naveen S, Larkin, James, Gore, Martin, Dvorak, Harold F, Paku, Sandor, Kerbel, Robert S, Dome, Balazs, and Reynolds, Andrew R

Published
2017
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