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52. Oral Anticoagulation and Functional Outcome after Intracerebral Hemorrhage

Author

Biffi, Alessandro, Kuramatsu, Joji B., Leasure, Audrey, Kamel, Hooman, Kourkoulis, Christina, Schwab, Kristin, Ayres, Alison M., Elm, Jordan, Gurol, M. Edip, Greenberg, Steven M., Viswanathan, Anand, Anderson, Christopher D., Schwab, Stefan, Rosand, Jonathan, Testai, Fernando D., Woo, Daniel, Huttner, Hagen B., and Sheth, Kevin N

Published
2017
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56. Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation

Author

Linnerbauer, Mathias, primary, Lößlein, Lena, additional, Vandrey, Oliver, additional, Tsaktanis, Thanos, additional, Beer, Alexander, additional, Naumann, Ulrike J., additional, Panier, Franziska, additional, Beyer, Tobias, additional, Nirschl, Lucy, additional, Kuramatsu, Joji B., additional, Winkler, Jürgen, additional, Quintana, Francisco J., additional, and Rothhammer, Veit, additional

Published
2022
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57. Association of intraventricular fibrinolysis with clinical outcomes in intracerebral hemorrhage: an individual participant data meta-analysis

Author

Kuramatsu, Joji B, Gerner, Stefan T, Falcone, Guido J, Selim, Magdy H, Lioutas, Vasileios-Arsenios, Endres, Matthias, Zweynert, Sarah, Vajkoczy, Peter, Ringleb, Peter A, Purrucker, Jan C, Volkmann, Jens, Neugebauer, Hermann, Ziai, Wendy, Erbguth, Frank, Schellinger, Peter D, Knappe, Ulrich J, Fink, Gereon R, Dohmen, Christian, Minnerup, Jens, Reichmann, Heinz, Schneider, Hauke, Röther, Joachim, Reimann, Gernot, Bardutzky, Jürgen, Schwarz, Michael, Bäzner, Hansjörg, Claßen, Joseph, Michalski, Dominik, Witte, Otto W, Günther, Albrecht, Hamann, Gerhard F, Lücking, Hannes, Dörfler, Arnd, Ishfaq, Muhammad Fawad, Sembill, Jochen A, Chang, Jason J, Testai, Fernando D, Woo, Daniel, Alexandrov, Andrei V, Staykov, Dimitre, Goyal, Nitin, Tsivgoulis, Georgios, Sheth, Kevin N, Awad, Issam A, Schwab, Stefan, Sprügel, Maximilian I, Hanley, Daniel F, Huttner, Hagen B, Collaborators, Sansing, Lauren, Matouk, Charles C, Leasure, Audrey, Sobesky, Jan, Bauer, Miriam, Schurig, Johannes, Rizos, Timolaos, Mrochen, Anne, Haeusler, Karl Georg, Müllges, Wolfgang, Kraft, Peter, Schubert, Anna-Lena, Stösser, Sebastian, Ludolph, Albert, Nueckel, Martin, Glahn, Jörg, Stetefeld, Henning, Rahmig, Jan, Kölbl, Kathrin, Fisse, Anna Lena, Michels, Peter, Schwert, Henning, Hagemann, Georg, Rakers, Florian, Wöhrle, Johannes C, Alshammari, Fahid, Horn, Markus, Bahner, Dirk, Urbanek, Christian, Ram, Malathi, Palm, Frederick, Grau, Armin, and Avadhani, Radhika

Subjects
Advanced and Specialized Nursing, drug therapy [Cerebral Hemorrhage], Fibrinolysis, diagnostic imaging [Cerebral Hemorrhage], intracerebral hemorrhage, mortality, Observational Studies as Topic, Treatment Outcome, Fibrinolytic Agents, standard of care, Drainage, Humans, Neurology (clinical), methods [Drainage], ddc:610, Cardiology and Cardiovascular Medicine, hydrocephalus, Cerebral Hemorrhage, Hydrocephalus
Abstract

Background: In patients with intracerebral hemorrhage (ICH), the presence of intraventricular hemorrhage constitutes a promising therapeutic target. Intraventricular fibrinolysis (IVF) reduces mortality, yet impact on functional disability remains unclear. Thus, we aimed to determine the influence of IVF on functional outcomes. Methods: This individual participant data meta-analysis pooled 1501 patients from 2 randomized trials and 7 observational studies enrolled during 2004 to 2015. We compared IVF versus standard of care (including placebo) in patients treated with external ventricular drainage due to acute hydrocephalus caused by ICH with intraventricular hemorrhage. The primary outcome was functional disability evaluated by the modified Rankin Scale (mRS; range: 0–6, lower scores indicating less disability) at 6 months, dichotomized into mRS score: 0 to 3 versus mRS: 4 to 6. Secondary outcomes included ordinal-shift analysis, all-cause mortality, and intracranial adverse events. Confounding and bias were adjusted by random effects and doubly robust models to calculate odds ratios and absolute treatment effects (ATE). Results: Comparing treatment of 596 with IVF to 905 with standard of care resulted in an ATE to achieve the primary outcome of 9.3% (95% CI, 4.4–14.1). IVF treatment showed a significant shift towards improved outcome across the entire range of mRS estimates, common odds ratio, 1.75 (95% CI, 1.39–2.17), reduced mortality, odds ratio, 0.47 (95% CI, 0.35–0.64), without increased adverse events, absolute difference, 1.0% (95% CI, −2.7 to 4.8). Exploratory analyses provided that early IVF treatment (≤48 hours) after symptom onset was associated with an ATE, 15.2% (95% CI, 8.6–21.8) to achieve the primary outcome. Conclusions: As compared to standard of care, the administration of IVF in patients with acute hydrocephalus caused by intracerebral and intraventricular hemorrhage was significantly associated with improved functional outcome at 6 months. The treatment effect was linked to an early time window

Published
2022

61. Simplified Edinburgh CT Criteria for Identification of Lobar Intracerebral Hemorrhage Associated With Cerebral Amyloid Angiopathy

Author

Sembill, Jochen A, primary, Knott, Michael, additional, Xu, Mingming, additional, Roeder, Sebastian S, additional, Hagen, Manuel, additional, Sprügel, Maximilian I., additional, Mrochen, Anne, additional, Borutta, Matthias, additional, Hoelter, Philip, additional, Engelhorn, Tobias, additional, Rothhammer, Veit, additional, Macha, Kosmas, additional, and Kuramatsu, Joji B., additional

Published
2022
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62. Hematoma Expansion and Clinical Outcomes in Patients With Factor-Xa Inhibitor–Related Atraumatic Intracerebral Hemorrhage Treated Within the ANNEXA-4 Trial Versus Real-World Usual Care

Author

Huttner, Hagen B., primary, Gerner, Stefan T., additional, Kuramatsu, Joji B., additional, Connolly, Stuart J., additional, Beyer-Westendorf, Jan, additional, Demchuk, Andrew M., additional, Middeldorp, Saskia, additional, Zotova, Elena, additional, Altevers, Julia, additional, Andersohn, Frank, additional, Christoph, Mary J., additional, Yue, Patrick, additional, Stross, Leonhard, additional, and Schwab, Stefan, additional

Published
2022
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63. Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury

Author

Rühl, Lena, primary, Kuramatsu, Joji B, additional, Sembill, Jochen A, additional, Kallmünzer, Bernd, additional, Madzar, Dominik, additional, Gerner, Stefan T, additional, Giede-Jeppe, Antje, additional, Balk, Stefanie, additional, Mueller, Tamara, additional, Jäger, Jakob, additional, Schwab, Stefan, additional, Huttner, Hagen B, additional, and Sprügel, Maximilian I, additional

Published
2022
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66. Hematoma enlargement characteristics in deep versus lobar intracerebral hemorrhage

Author

Sembill, Jochen A., Kuramatsu, Joji B., Gerner, Stefan T., Sprügel, Maximilian I., Roeder, Sebastian S., Madžar, Dominik, Hagen, Manuel, Hoelter, Philip, Lücking, Hannes, Dörfler, Arnd, Schwab, Stefan, and Huttner, Hagen B.

Subjects
Aged, 80 and over, Male, Clinical Trials as Topic, Hematoma, Vitamin K, Anticoagulants, Neurosciences. Biological psychiatry. Neuropsychiatry, Middle Aged, nervous system diseases, Cohort Studies, Germany, Humans, Female, Single-Blind Method, Registries, cardiovascular diseases, Neurology. Diseases of the nervous system, RC346-429, Cerebrum, Research Articles, Research Article, Aged, Cerebral Hemorrhage, Cerebral Intraventricular Hemorrhage, RC321-571
Abstract

Objective Hematoma enlargement (HE) is associated with clinical outcomes after supratentorial intracerebral hemorrhage (ICH). This study evaluates whether HE characteristics and association with functional outcome differ in deep versus lobar ICH. Methods Pooled analysis of individual patient data between January 2006 and December 2015 from a German‐wide cohort study (RETRACE, I + II) investigating ICH related to oral anticoagulants (OAC) at 22 participating centers, and from one single‐center registry (UKER‐ICH) investigating non‐OAC‐ICH patients. Altogether, 1954 supratentorial ICH patients were eligible for outcome analyses, which were separately conducted or controlled for OAC, that is, vitamin‐K‐antagonists (VKA, n = 1186) and non‐vitamin‐K‐antagonist‐oral‐anticoagulants (NOAC, n = 107). Confounding was addressed using propensity score matching, cox regression modeling and multivariate modeling. Main outcomes were occurrence, extent, and timing of HE (>33%/>6 mL) and its association with 3‐month functional outcome. Results Occurrence of HE was not different after deep versus lobar ICH in patients with non‐OAC‐ICH (39/356 [11.0%] vs. 36/305 [11.8%], P = 0.73), VKA‐ICH (249/681 [36.6%] vs. 183/505 [36.2%], P = 0.91), and NOAC‐ICH (21/69 [30.4%] vs. 12/38 [31.6%], P = 0.90). HE extent did not differ after non‐OAC‐ICH (deep:+59% [40–122] vs. lobar:+74% [37–124], P = 0.65), but both patients with VKA‐ICH and NOAC‐ICH showed greater HE extent after deep ICH [VKA‐ICH, deep: +94% [54–199] vs. lobar: +56% [35–116], P

Published
2020

67. Vaccine-Induced Thrombocytopenia with Severe Headache

Author

Salih, Farid, primary, Schönborn, Linda, additional, Kohler, Siegfried, additional, Franke, Christiana, additional, Möckel, Martin, additional, Dörner, Thomas, additional, Bauknecht, Hans C., additional, Pille, Christian, additional, Graw, Jan A., additional, Alonso, Angelika, additional, Pelz, Johann, additional, Schneider, Hauke, additional, Bayas, Antonios, additional, Christ, Monika, additional, Kuramatsu, Joji B., additional, Thiele, Thomas, additional, Greinacher, Andreas, additional, and Endres, Matthias, additional

Published
2021
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68. Neues beim Schlaganfall: Prävention

Author

Diener, Hans-Christoph, additional, Endres, Matthias, additional, Fiehler, Jens, additional, Gerloff, Christian, additional, Häusler, Karl Georg, additional, Kuramatsu, Joji B., additional, Pfeilschifter, Waltraud, additional, Poli, Sven, additional, Purrucker, Jan Christoph, additional, Bonin-Schnabel, Renate, additional, Sembill, Jochen A., additional, Veltkamp, Roland, additional, and Weimar, Christian, additional

Published
2021
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72. Stent-Assisted Coiling Using Leo+ Baby Stent

Author

Luecking, Hannes, Struffert, Tobias, Goelitz, Philipp, Engelhorn, Tobias, Brandner, Sebastian, Kuramatsu, Joji B., Lang, Stefan, Schmidt, Manuel, and Doerfler, Arnd

Subjects
ddc:610
Abstract

Background Stent-assisted coiling is well-established for treatment of cerebral aneurysms. The technique enables treatment of wide-neck, bifurcation and recurrent aneurysms with high packing rates. While described in extenso for laser cut stents, the results of patients treated with the Leo+ Baby (Balt, Montmorency, France) braided microstent are presented. Material and Methods Patients were included if treated with a Leo+ Baby and with digital subtraction angiography (DSA) follow-up available of at least 6 months. Data were evaluated for successful deployment, aneurysm occlusion according to the modified Raymond-Roy classification (MRRC), stent patency and procedure-related morbidity and mortality. Results A total of 81 patients were included and Leo+ Baby deployment was successful in all cases. Coils were used in 80 cases. In 1 case 2 stents were used stent-in-stent without additional coiling. Initial aneurysm occlusion rates were MRRCi1 51.9%, MRRCi2 11.1%, MRRCi3a 24.7% and MRRCi3b 12.3%. Occlusion rates after 6 months were MRRC6m1 78.9%, MRRC6m2 3.9%, MRRC6m3a 6.6% and MRRC6m3b 10.5%. Procedure-related morbidity was 1 case of acute stent thrombosis successfully treated with tirofiban and 1 case with transient hemiparesis due to stent thrombosis after 4 months. There was 1 case of coil-associated subarachnoid hemorrhage (SAH) which caused prolonged hospitalization. No procedure-related mortality was observed. Conclusion The results confirm that stent-assisted coiling with the Leo+ Baby stent is safe and efficient for treatment of wide neck or recurrent cerebral aneurysms. Spontaneous progressive aneurysm occlusion over 6 months supports the theory of considerable flow-modulating effects of Leo+ Baby.

Published
2021

73. Disability-Adjusted Life-Years Associated With Intracerebral Hemorrhage and Secondary Injury

Author

Haupenthal, David, primary, Kuramatsu, Joji B., additional, Volbers, Bastian, additional, Sembill, Jochen A., additional, Mrochen, Anne, additional, Balk, Stefanie, additional, Hoelter, Philip, additional, Lücking, Hannes, additional, Engelhorn, Tobias, additional, Dörfler, Arnd, additional, Schwab, Stefan, additional, Huttner, Hagen B., additional, and Sprügel, Maximilian I., additional

Published
2021
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74. Anticoagulant Reversal, Blood Pressure Levels, and Anticoagulant Resumption in Patients With Anticoagulation-Related Intracerebral Hemorrhage

Author

Kuramatsu, Joji B., Gerner, Stefan T., Schellinger, Peter D., Glahn, Jörg, Endres, Matthias, Sobesky, Jan, Flechsenhar, Julia, Neugebauer, Hermann, Jüttler, Eric, Grau, Armin, Palm, Frederick, Röther, Joachim, Michels, Peter, Hamann, Gerhard F., Hüwel, Joachim, Hagemann, Georg, Barber, Beatrice, Terborg, Christoph, Trostdorf, Frank, Bäzner, Hansjörg, Roth, Aletta, Wöhrle, Johannes, Keller, Moritz, Schwarz, Michael, Reimann, Gernot, Volkmann, Jens, Müllges, Wolfgang, Kraft, Peter, Classen, Joseph, Hobohm, Carsten, Horn, Markus, Milewski, Angelika, Reichmann, Heinz, Schneider, Hauke, Schimmel, Eik, Fink, Gereon R., Dohmen, Christian, Stetefeld, Henning, Witte, Otto, Günther, Albrecht, Neumann-Haefelin, Tobias, Racs, Andras E., Nueckel, Martin, Erbguth, Frank, Kloska, Stephan P., Dörfler, Arnd, Köhrmann, Martin, Schwab, Stefan, and Huttner, Hagen B.

Published
2015
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76. Influence of Early Enteral Nutrition on Clinical Outcomes in Neurocritical Care Patients With Intracerebral Hemorrhage

Author

Peng, Jianhua, primary, Volbers, Bastian, additional, Sprügel, Maximilian I., additional, Hoelter, Philip, additional, Engelhorn, Tobias, additional, Jiang, Yong, additional, Kuramatsu, Joji B., additional, Huttner, Hagen B., additional, Dörfler, Arnd, additional, Schwab, Stefan, additional, and Gerner, Stefan T., additional

Published
2021
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79. Impact of Statins on Hematoma, Edema, Seizures, Vascular Events, and Functional Recovery After Intracerebral Hemorrhage

Author

Sprügel, Maximilian I., primary, Kuramatsu, Joji B., additional, Volbers, Bastian, additional, Saam, Justina I., additional, Sembill, Jochen A., additional, Gerner, Stefan T., additional, Balk, Stefanie, additional, Hamer, Hajo M., additional, Lücking, Hannes, additional, Hölter, Philip, additional, Nolte, Christian H., additional, Scheitz, Jan F., additional, Rocco, Andrea, additional, Endres, Matthias, additional, and Huttner, Hagen B., additional

Published
2021
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80. Neues beim Schlaganfall – Teil 2: Prävention

Author

Diener, Hans-Christoph, additional, Endres, Matthias, additional, Fiehler, Jens, additional, Gerloff, Christian, additional, Häusler, Hans Georg, additional, Kuramatsu, Joji B, additional, Pfeilschifter, Waltraud, additional, Poli, Sven, additional, Purrucker, Jan, additional, Schnabel, Renate, additional, Sembill, Jochen, additional, Veltkamp, Roland, additional, and Weimar, Christian, additional

Published
2021
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81. Neues beim Schlaganfall – Teil 1: Akuttherapie

Author

Diener, Hans-Christoph, additional, Fiehler, Jens, additional, Häusler, Karl Georg, additional, Kuramatsu, Joji B., additional, Pfeilschifter, Waltraud, additional, Purrucker, Jan Christoph, additional, Schnabel, Renate B., additional, Sembill, Jochen A., additional, Veltkamp, Roland, additional, and Weimar, Christian, additional

Published
2021
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82. Beyond Functional Impairment: Redefining Favorable Outcome in Patients with Subarachnoid Hemorrhage

Author

Custal, Christina, primary, Koehn, Julia, additional, Borutta, Matthias, additional, Mrochen, Anne, additional, Brandner, Sebastian, additional, Eyüpoglu, Ilker Y., additional, Lücking, Hannes, additional, Hoelter, Philip, additional, Kuramatsu, Joji B., additional, Kornhuber, Johannes, additional, Schwab, Stefan, additional, Huttner, Hagen B., additional, and Gerner, Stefan T., additional

Published
2021
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83. sj-pdf-1-wso-10.1177_1747493020971878 - Supplemental material for Parenchymatous hematoma in patients with atraumatic subarachnoid hemorrhage: Characteristics, treatment, and clinical outcomes

Author

Gerner, Stefan T, Hülsbrink, Robert, Reichl, Jonathan, Mrochen, Anne, Ilker Y Eyüpoglu, Brandner, Sebastian, Dörfler, Arnd, Engelhorn, Tobias, Kuramatsu, Joji B, Schwab, Stefan, and Huttner, Hagen B

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_1747493020971878 for Parenchymatous hematoma in patients with atraumatic subarachnoid hemorrhage: Characteristics, treatment, and clinical outcomes by Stefan T Gerner, Robert Hülsbrink, Jonathan Reichl, Anne Mrochen, Ilker Y Eyüpoglu, Sebastian Brandner, Arnd Dörfler, Tobias Engelhorn, Joji B Kuramatsu, Stefan Schwab and Hagen B Huttner: on behalf of the Dutch T1 CRC Working Group in International Journal of Stroke

Published
2020
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85. Multicenter Validation of the max‐ICH Score in Intracerebral Hemorrhage

Author

Sembill, Jochen A., primary, Castello, Juan P., additional, Sprügel, Maximilian I., additional, Gerner, Stefan T., additional, Hoelter, Philip, additional, Lücking, Hannes, additional, Doerfler, Arnd, additional, Schwab, Stefan, additional, Huttner, Hagen B., additional, Biffi, Alessandro, additional, and Kuramatsu, Joji B., additional

Published
2020
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86. Parenchymatous hematoma in patients with atraumatic subarachnoid hemorrhage: Characteristics, treatment, and clinical outcomes

Author

Gerner, Stefan T, primary, Hülsbrink, Robert, additional, Reichl, Jonathan, additional, Mrochen, Anne, additional, Eyüpoglu, Ilker Y, additional, Brandner, Sebastian, additional, Dörfler, Arnd, additional, Engelhorn, Tobias, additional, Kuramatsu, Joji B, additional, Schwab, Stefan, additional, and Huttner, Hagen B, additional

Published
2020
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89. Bedside Catheter Hematoma Evacuation in Vitamin K Antagonist-Related Intracerebral Hemorrhage: A Safe and Feasible Approach

Author

Volbers, Bastian, primary, Niesen, Wolf-Dirk, additional, Amiri-Soltani, Samuel, additional, Staykov, Dimitre, additional, Shah, Mukesch Johannes, additional, Lang, Stefan, additional, Lücking, Hannes, additional, Kuramatsu, Joji B., additional, Huttner, Hagen B., additional, Schwab, Stefan, additional, and Bardutzky, Jürgen, additional

Published
2020
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90. Stent-Assisted Coiling Using Leo+ Baby Stent

Author

Luecking, Hannes, primary, Struffert, Tobias, additional, Goelitz, Philipp, additional, Engelhorn, Tobias, additional, Brandner, Sebastian, additional, Kuramatsu, Joji B., additional, Lang, Stefan, additional, Schmidt, Manuel, additional, and Doerfler, Arnd, additional

Published
2020
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94. Age-dependent clinical outcomes in primary versus oral anticoagulation-related intracerebral hemorrhage

Author

Sprügel, Maximilian I, primary, Kuramatsu, Joji B, additional, Gerner, Stefan T, additional, Sembill, Jochen A, additional, Madžar, Dominik, additional, Reindl, Caroline, additional, Bobinger, Tobias, additional, Müller, Tamara, additional, Hoelter, Philip, additional, Lücking, Hannes, additional, Engelhorn, Tobias, additional, and Huttner, Hagen B, additional

Published
2019
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95. Association of Surgical Hematoma Evacuation vs Conservative Treatment With Functional Outcome in Patients With Cerebellar Intracerebral Hemorrhage

Author

Kuramatsu, Joji B., primary, Biffi, Alessandro, additional, Gerner, Stefan T., additional, Sembill, Jochen A., additional, Sprügel, Maximilian I., additional, Leasure, Audrey, additional, Sansing, Lauren, additional, Matouk, Charles, additional, Falcone, Guido J., additional, Endres, Matthias, additional, Haeusler, Karl Georg, additional, Sobesky, Jan, additional, Schurig, Johannes, additional, Zweynert, Sarah, additional, Bauer, Miriam, additional, Vajkoczy, Peter, additional, Ringleb, Peter A., additional, Purrucker, Jan, additional, Rizos, Timolaos, additional, Volkmann, Jens, additional, Müllges, Wolfgang, additional, Kraft, Peter, additional, Schubert, Anna-Lena, additional, Erbguth, Frank, additional, Nueckel, Martin, additional, Schellinger, Peter D., additional, Glahn, Jörg, additional, Knappe, Ulrich J., additional, Fink, Gereon R., additional, Dohmen, Christian, additional, Stetefeld, Henning, additional, Fisse, Anna Lena, additional, Minnerup, Jens, additional, Hagemann, Georg, additional, Rakers, Florian, additional, Reichmann, Heinz, additional, Schneider, Hauke, additional, Rahmig, Jan, additional, Ludolph, Albert Christian, additional, Stösser, Sebastian, additional, Neugebauer, Hermann, additional, Röther, Joachim, additional, Michels, Peter, additional, Schwarz, Michael, additional, Reimann, Gernot, additional, Bäzner, Hansjörg, additional, Schwert, Henning, additional, Claßen, Joseph, additional, Michalski, Dominik, additional, Grau, Armin, additional, Palm, Frederick, additional, Urbanek, Christian, additional, Wöhrle, Johannes C., additional, Alshammari, Fahid, additional, Horn, Markus, additional, Bahner, Dirk, additional, Witte, Otto W., additional, Günther, Albrecht, additional, Hamann, Gerhard F., additional, Hagen, Manuel, additional, Roeder, Sebastian S., additional, Lücking, Hannes, additional, Dörfler, Arnd, additional, Testai, Fernando D., additional, Woo, Daniel, additional, Schwab, Stefan, additional, Sheth, Kevin N., additional, and Huttner, Hagen B., additional

Published
2019
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96. ESO863606 Supplemental Material - Supplemental material for Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11–13 November 2018

Author

Niaz Ahmed, Audebert, Heinrich, Turc, Guillaume, Cordonnier, Charlotte, Christensen, Hanne, Sacco, Simona, Sandset, Else Charlotte, Ntaios, George, Charidimou, Andreas, Toni, Danilo, Pristipino, Christian, Köhrmann, Martin, Kuramatsu, Joji B, Thomalla, Götz, Mikulik, Robert, Ford, Gary A, Martí-Fàbregas, Joan, Fischer, Urs, Thoren, Magnus, Lundström, Erik, Rinkel, Gabriel JE, H Bart Van Der Worp, Matusevicius, Marius, Tsivgoulis, Georgios, Haralampos Milionis, Rubiera, Marta, Hart, Robert, Moreira, Tiago, Lantz, Maria, Sjöstrand, Christina, Andersen, Grethe, Schellinger, Peter, Kostulas, Konstantinos, Sunnerhagen, Katharina Stibrant, Keselman, Boris, Korompoki, Eleni, Purrucker, Jan, Khatri, Pooja, Whiteley, William, Berge, Eivind, Mazya, Michael, Dippel, Diederik WJ, Mustanoja, Satu, Rasmussen, Mads, Söderqvist, Åsa Kuntze, Escudero-Martínez, Irene, and Steiner, Thorsten

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, ESO863606 Supplemental Material for Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11–13 November 2018 by Niaz Ahmed, Heinrich Audebert, Guillaume Turc, Charlotte Cordonnier, Hanne Christensen, Simona Sacco, Else Charlotte Sandset, George Ntaios, Andreas Charidimou, Danilo Toni, Christian Pristipino, Martin Köhrmann, Joji B Kuramatsu, Götz Thomalla, Robert Mikulik, Gary A Ford, Joan Martí-Fàbregas, Urs Fischer, Magnus Thoren, Erik Lundström, Gabriel JE Rinkel, H Bart van der Worp, Marius Matusevicius, Georgios Tsivgoulis, Haralampos Milionis, Marta Rubiera, Robert Hart, Tiago Moreira, Maria Lantz, Christina Sjöstrand, Grethe Andersen, Peter Schellinger, Konstantinos Kostulas, Katharina Stibrant Sunnerhagen, Boris Keselman, Eleni Korompoki, Jan Purrucker, Pooja Khatri, William Whiteley, Eivind Berge, Michael Mazya, Diederik WJ Dippel, Satu Mustanoja, Mads Rasmussen, Åsa Kuntze Söderqvist, Irene Escudero-Martínez and Thorsten Steiner in European Stroke Journal

Published
2019
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97. Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11-13 November 2018

Author

Ahmed, Niaz Audebert, Heinrich Turc, Guillaume Cordonnier, Charlotte Christensen, Hanne Sacco, Simona Sandset, Else Charlotte Ntaios, George Charidimou, Andreas Toni, Danilo and Pristipino, Christian Koehrmann, Martin Kuramatsu, Joji B. and Thomalla, Geotz Mikulik, Robert Ford, Gary A. and Marti-Fabregas, Joan Fischer, Urs Thoren, Magnus Lundstrom, Erik Rinkel, Gabriel J. E. van der Worp, H. Bart and Matusevicius, Marius Tsivgoulis, Georgios Milionis, Haralampos and Rubiera, Marta Hart, Robert Moreira, Tiago Lantz, Maria and Sjostrand, Christina Andersen, Grethe Schellinger, Peter and Kostulas, Konstantinos Sunnerhagen, Katharina Stibrant Keselman, Boris Korompoki, Eleni Purrucker, Jan Khatri, Pooja and Whiteley, William Berge, Eivind Mazya, Michael Dippel, Diederik W. J. Mustanoja, Satu Rasmussen, Mads Soderqvist, Asa Kuntze Escudero-Martinez, Irene Steiner, Thorsten

Abstract

The purpose of the European Stroke Organisation-Karolinska Stroke Update Conference is to provide updates on recent stroke therapy research and to give an opportunity for the participants to discuss how these results may be implemented into clinical routine. The meeting started 22 years ago as Karolinska Stroke Update, but since 2014 it is a joint conference with European Stroke Organisation. Importantly, it provides a platform for discussion on the European Stroke Organisation guidelines process and on recommendations to the European Stroke Organisation guidelines committee on specific topics. By this, it adds a direct influence from stroke professionals otherwise not involved in committees and work groups on the guideline procedure. The discussions at the conference may also inspire new guidelines when motivated. The topics raised at the meeting are selected by the scientific programme committee mainly based on recent important scientific publications. This year's European Stroke Organisation-Karolinska Stroke Update Meeting was held in Stockholm on 11-13 November 2018. There were 11 scientific sessions discussed in the meeting including two short sessions. Each session except the short sessions produced a consensus statement (Full version with background, issues, conclusions and references are published as web-material and at and ) and recommendations which were prepared by a writing committee consisting of session chair(s), scientific secretary and speakers. These statements were presented to the 250 participants of the meeting. In the open meeting, general participants commented on the consensus statement and recommendations and the final document were adjusted based on the discussion from the general participants Recommendations (grade of evidence) were graded according to the 1998 Karolinska Stroke Update meeting with regard to the strength of evidence. Grade A Evidence: Strong support from randomised controlled trials and statistical reviews (at least one randomised controlled trial plus one statistical review). Grade B Evidence: Support from randomised controlled trials and statistical reviews (one randomised controlled trial or one statistical review). Grade C Evidence: No reasonable support from randomised controlled trials, recommendations based on small randomised and/or non-randomised controlled trials evidence.

Published
2019

98. Parenchymatous hematoma in patients with atraumatic subarachnoid hemorrhage: Characteristics, treatment, and clinical outcomes.

Author

Gerner, Stefan T, Hülsbrink, Robert, Reichl, Jonathan, Mrochen, Anne, Eyüpoglu, Ilker Y, Brandner, Sebastian, Dörfler, Arnd, Engelhorn, Tobias, Kuramatsu, Joji B, Schwab, Stefan, and Huttner, Hagen B

Subjects
INTRACRANIAL aneurysms, TREATMENT effectiveness, SUBARACHNOID hemorrhage, FUNCTIONAL assessment, HEMATOMA, PROPENSITY score matching, INTRAVENTRICULAR hemorrhage
Abstract

Background: Data regarding the influence of concomitant parenchymatous hematoma (PH) on long-term outcomes in patients with atraumatic subarachnoid hemorrhage (SAH) are scarce. Further, it is not established if these patients benefit from surgical intervention. Aim: The aim of this study was to determine the influence of concomitant PH in SAH patients on functional long-term outcome, and whether these patients may benefit from surgical hematoma evacuation. Methods: Over a 5-year period, all consecutive patients with SAH treated at the Departments of Neurology, Neuroradiology, and Neurosurgery, at the University Hospital Erlangen (Germany) were recorded. In addition to the clinical and imaging characteristics of SAH, we documented the presence, location, and volume of PH as well as treatment parameters. Outcome assessment at 12 months included functional outcome (modified Rankin scale (mRS), favorable = 0–2), health-related quality of life, and long-term complications. For outcome analysis, a propensity score matching (ratio 1:1, caliper 0.1) was performed to compare SAH patients with and without PH. Sub-analyses were performed regarding PH treatment (surgical evacuation vs. conservative). Results: A total of 494 patients with atraumatic SAH were available. Eighty-five (17.2%) had PH on initial imaging. SAH patients with PH had a worse clinical condition on admission and had a greater extent of subarachnoid/intraventricular hemorrhage. Median PH volume was 11.0 ml (5.4–31.8) with largest volumes observed in patients with ruptured middle cerebral artery (MCA)-aneurysm (31.7 ml (16.3–43.2)). After propensity-score matching (PSM), patients with PH had worse functional outcomes at 12 months (modified Rankin scale (mRS) 0–2: PH 31.8% vs. ØPH57.7% p < 0.001), and a lower rate of self-reported health compared to patients without PH (EQ-5D VAS: PH 50(30–70) vs. ØPH 80(65–95); p < 0.001). In PH patients, surgical evacuation was associated with a higher rate of favorable outcome at 12 months compared to those treated conservatively (surgery 14/28 (50.0%) vs. conservative 14/57 (24.6%); adjusted odds-ratio (OR; 95%CI): 1.34 (1.08–1.66); p = 0.001), irrespective of aneurysm location. Subgroup-analysis revealed positive associations of surgical hematoma evacuation with outcome in subgroups with larger PH volumes (>10 ml; OR (95%CI): 1.39 (1.09–1.79)), frontal PH location (OR 1.59 (1.14–2.23)), and early surgery (within 600 min after onset; OR 1.42 (1.03–1.94)). Conclusions: Concomitant PH occurs frequently in patients with SAH and is associated with functional impairment after 1 year. Surgical evacuation of PH may improve outcomes in these patients, irrespective of aneurysm-location. [ABSTRACT FROM AUTHOR]

Published
2021
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99. Amantadine treatment is associated with improved consciousness in patients with non-traumatic brain injury

Author

Ru¨hl, Lena, Kuramatsu, Joji B, Sembill, Jochen A, Kallmu¨nzer, Bernd, Madzar, Dominik, Gerner, Stefan T, Giede-Jeppe, Antje, Balk, Stefanie, Mueller, Tamara, Ja¨ger, Jakob, Schwab, Stefan, Huttner, Hagen B, and Spru¨gel, Maximilian I

Abstract

ObjectiveThis study determined the effect of amantadine treatment on consciousness in patients with non-traumatic brain injury.MethodsWe pooled individual patient data of five single-centre observational studies to determine the effect of amantadine treatment among patients with ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, community-acquired bacterial meningitis and status epilepticus, admitted between January 2012 and December 2015 and ventilated ≥7 days. Patient selection and multivariable regression modelling were used to adjust for differences in intergroup comparison and for parameters associated with consciousness. Improvement of consciousness 5 days after treatment initiation was defined as primary outcome. Secondary outcomes included Glasgow Coma Scale (GCS) at day 5 and GCS at day 10, rate of ICU delirium, epileptic seizures and all-cause mortality at 90 days.ResultsOverall, 84 of 294 (28.6%) eligible patients received amantadine. Amantadine treatment was associated with improvement of consciousness at day 5 (amantadine: 86.9% vs control: 54.0%; absolute difference: 32.9 (20.0–44.2); adjusted OR (aOR): 5.71 (2.50–13.05), p<0.001). Secondary outcomes showed differences in GCS 5 days (9 (8–11) vs 6 (3–9), p<0.001) and GCS 10 days (10(8–11) vs 9(6–11),p=0.003) after treatment initiation. There were no significant differences regarding all-cause mortality (aOR: 0.89 (0.44–1.82), p=0.758) and ICU delirium (aOR: 1.39 (0.58–3.31), p=0.462). Rate of epileptic seizures after initiation of amantadine treatment was numerically higher in the amantadine group (amantadine: 10.7% vs control: 3.0%; absolute difference: 7.7 (0.3–16.4); aOR: 3.68 (0.86–15.71), p=0.079).ConclusionsAmantadine treatment is associated with improved consciousness among patients with different types of non-traumatic brain injury in this observational cohort analysis. Epileptic seizures should be considered as potential side effects and randomised controlled trials are needed to confirm these findings.

Published
2022
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100. Autorinnen und Autoren

Author

Andresen, Viola, Berlit, Peter, Bingel, Ulrike, Burger, Michael, Daniels, Christine, Deuschl, Günther, Diener, Cristoph, Eckstein, Hans-Henning, Elger, Christian E., Erbguth, Frank, Eyüpoglu, Ilker, Faissner, Simon, Fink, Gereon R., Forsting, Michael, Gold, Ralf, Goldbrunner, Roland, Heuß, Dieter F., Jeub, Monika, Jordan, Berit, Kastrup, Oliver, Klein, Matthias, Kleine-Borgmann, Julian, Kovac, Stjepana, Kuramatsu, Joji B., Layer, Peter, Lehmann, Helmar C., Limmroth, Volker, Neuneier, Janina, Nickenig, Georg, Onur, Özgür, Pfister, Hans-Walter, Schlamann, Marc, Schneider-Gold, Christiane, Scholz, Martin, Schwab, Stefan, Sommer, Christof-Matthias, Steinbach, Joachim, Strupp, Michael, Schassen, K. Henrike von, Voß, Martin, Wallesch, Claus-Werner, and Zierz, Stephan

Published
2024
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