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51. D-Dimer as Predictor of Large Vessel Occlusion in Acute Ischemic Stroke

Author: Ramos-Pachón, Anna, primary, López-Cancio, Elena, additional, Bustamante, Alejandro, additional, Pérez de la Ossa, Natàlia, additional, Millán, Mònica, additional, Hernández-Pérez, Maria, additional, Garcia-Berrocoso, Teresa, additional, Cardona, Pere, additional, Rubiera, Marta, additional, Serena, Joaquín, additional, Ustrell, Xavier, additional, Garcés, Moisés, additional, Terceño, Mikel, additional, Dávalos, Antoni, additional, and Montaner, Joan, additional
Published: 2021
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52. Design and Validation of a Prehospital Stroke Scale to Predict Large Arterial Occlusion: The Rapid Arterial Occlusion Evaluation Scale

Author: Pérez de la Ossa, Natalia, Carrera, David, Gorchs, Montse, Querol, Marisol, Millán, Mònica, Gomis, Meritxell, Dorado, Laura, López-Cancio, Elena, Hernández-Pérez, María, Chicharro, Vicente, Escalada, Xavier, Jiménez, Xavier, and Dávalos, Antoni
Published: 2014
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53. Cognitive Patterns in Relation to Biomarkers of Cerebrovascular Disease and Vascular Risk Factors

Author: Miralbell, Júlia, López-Cancio, Elena, López-Oloriz, Jorge, Arenillas, Juan Francisco, Barrios, Maite, Soriano-Raya, Juan José, Galán, Amparo, Cáceres, Cynthia, Alzamora, Maite, Pera, Guillem, Toran, Pere, Dávalos, Antoni, and Mataró, Maria
Published: 2013
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54. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas

Author: Garcia-Tornel, Alvaro, Millan, Monica, Rubiera, Marta, Bustamante, Alejandro, Requena, Manuel, Dorado, Laura, Olivé-Gadea, Marta, Jiménez, Xavier, Soto, Angels, Querol, Marisol, Hernández-Pérez, Maria, Gomis, Meritxell, Cardona, Pere, Urra, Xabier, Purroy, Francesc, Silva, Yolanda, Ustrell, Xavier, Esteve, Patricia, Salvat-Plana, Mercè, Gallofré, Miquel, Molina, Carlos, Dávalos, Antoni, Jovin, Tudor, Abilleira, Sonia, Ribo, Marc, Pérez de la Ossa, Natalia, Jacobi, Marc Ribó, Sanjuan, Estela, Santana, Katherine, Rodríguez, Noelia, Pagola, Jorge, Rodriguez-Luna, David, Maisterra, Olga, Santamarina, Estevo, Muchada, Marian, Juega, Jesús, Boned, Sandra, Franco, Antonio Palasi, García -Tornel, Álvaro, Deck, Matías, Sala, Victoria, Muñoz, Lucía, Millán, Mónica, López-Cancio, Elena, Hernández-Pérez, María, Ciurans, Jordi, Samaniego, Daniela, Canento, Tamara, Martin, Lorena, Planas, Anna, Broto, Joaquin, Sorrentino, Agustín, Paré, Martí, Zhu, Nuole, Garrido, Alicia, Grau, Laia, Crespo, Ane Miren, Presas, Silvia, Almendrote, Miriam, Ramos, Alba, Lucente, Giuseppe, Ispierto, Lourdes, Lozano, Manuel, Becerra, Juan Luis, Jiménez, Marta, Rolán, Dolores Vilas, Guanyabens, Nicolas, Sanchez-Ojanguren, Josep, Martínez-Piñeiro, Alicia, Forcén, Sara, Gea, Mireia, Álvarez, Marta, Ramos, Anna, Lizarbe, Manuel Domínguez, Sara, Guerra, Rubio, Bragado, Irene, Arbex, Andrea, Rodríguez, Luis, Portela, Pere Cardona, García, Helena Quesada, Rodríguez, Blanca Lara, Cayuela, Nuria, Miró, Julia, Marzal, Clara, Paipa, Andrés, Campoy, Sergio, Núñez, Ana, Arroyo, Pablo, Besora, Sarah, Adell, Vanessa, Campdelacreu, Jaume, Martí, Montse Alemany, González, Belén, Vila, Laura Bau, Crespo, Marta Fiter, Berbel, Anna, Urbaneja, Ma. Cristina Villaescusa, Guillen, Núria, Vidal, Nuria, Vérez Santamaria, Patricia Valentina, Navarro, Diego Herrero, Simó, Marta, Falip, Mercedes, Matas, Elisabeth, Ochoa, Neus Mongay, Gifreu, Ariadna, Muñoz, Albert, Romero, Lucía, Portell, Eduard, Perez, Guillermo Hernández, Esteve, F. Ruiz, Teixidor, Silvia, Talavera, Augusto Salazar, Gómez, Roser, Nuin, Xabier Urra, Vargas, Martha, Chamorro, Ángel, Amaro, Sergio, Llull, Laura, Renú, Arturo, Rudilosso, Salvatore, del Valle, Raquel Sánchez, Ariño, Helena, Solà, Nuria, la Puma, Delón, Gil, Francisco, Gómez, Juan Bernardo, Matos, Nuria, Falgàs, Neus, Borrego, Sergi, Sánchez, Almudena, Balasa, Mircea, Montejo, Carmen, Guasp, Mar, Reyes, David, Cervilla, Pablo Sánchez, Contador, Jose Miguel, Vera Monge, Victor Augusto, Ramos, Oscar, Rodríguez, Alejandro, Campello, Ana Rodríguez, Ballester, Gemma Romeral, Trujillano, Mireia Llop, Steinhauer, Eva Giralt, Godia, Elisa Cuadrado, Ois Santiago, Angel Javier, Conde, Jordi Jimenez, Fábregas, Joan Martí, Guisado, Daniel, Prats, Luís, Camps, Pol, Delgado, Raquel, Domeño, Alejandro Martínez, Marín, Rebeca, Cànovas, David, Estela, Jordi, Ros, Marta, Aranceta, Sonsoles, Espinosa, Jordi, Rubio, Marta, Lafuente, Cristina, Barrachina, Oriol, Anguita, Alicia, Reverter, Anna, García, Carmen, Sansa, Gemma, Hervas, Mariona, Crosas, Monica, Delgado, Tania, Krupinski, Jerzy, Folch, Sonia Huertas, Gamito, Gemma Muñoz, Alvarez, Josep Trenado, Subirana, Teresa, Molina, Jessica, Besora, Sarah, Romero, Laura Comes, Valls, Gemma Guardia, Jover, Miriam, Sotova, Javier Joaquín, García Sánchez, Sonia Mª, Valenzuela (intensivista), Sebastian, Gómez-Choco, Manuel, Mengual, Juan José, Font, M. Àngels, Gómez Ruiz, Mª Isabel, Zubizarreta, Irati, González, Susana Fernández, Gubieras, Laura, Cobos, Carmen E., Romo, Luis Mena, Caballol, Nuria, Cano, Luis, Leal, Joaquín Serena, Izarra, Mikel Terceño, Trigo, Irene Bragado, Viturro, Saima Bashir, Albiñana, Laura Pardo, Garrido, Montserrat Reina, Cazcarra, Carla Marco, Uscamaita, Karol Enrique, Márquez, Fabian, Coll, Cristina, Lloret Villlas, Mar Irida, Vila, Berta Solano, Alemany Perna, Berta, Domínguezl, Daniel López, de Lera, Mercedes, Cots Foraster, Anna, Vera Monge, Victor Augusto, Bojaryn, Urszula, Benabdelhak, Ikram, Capdevila, Gerard Mauri, Sanahuja Montesinos, Jordi, Vázquez, Daniel, Vicente Hervás, José, González, Cristina, Quílez, Alejandro, Pascual, Mikel Vicente, Ruiz, María, Riba, Yolanda, Gil Villar, M. Pilar, García, Cristina, Roig, Xavier Ustrell, Mora, Mònica Baldrich, Guinjoan, Anna Pellisé, Borras, Judit, Mañé Martínez, Alba, Marés, Rafael, Viñas i Gaya, Jaume, Seró, Laia, Flores, Alan, Rodríguez, Paula, Castilho, Gislaine, Ortega, Angela Monterde, Reverté, Silvia, Zaragoza, Josep, Baiges, Joan Josep, Zaragoza, Josep, Ozaeta, Gisela Martín, Escalante, Sonia, Payo, Iago, Salvado, Júlia Saura, Sala, Natalia Mas, Soler Insa, Josep M, Vilamala, Ester Tio, Navarro, Josep Abos, Tabuenca, Héctor Cruz, Canento Sánchez, Tamara, Ros, Marta, Matos, Nuria, Roldán, Elisabet, Rubiol, Elsa Puiggrós, Franquet, Elisabet, Fuentes, Lidia, Donaire, Javier, Martí, Elena, Giménez, Laura, Vázquez, Junior Gil, Clara Gris Ambrós, Eloisa Nieto, Rodríguez, Puri, Oletta, José Félix, Mellado, Pilar Pons, Catena, Gómez, Bárbara, Raileau, Vergilin, Ruíz, Esther Catena, Pardina, Oscar, Mercadal, Jordi, López-Diéguez, María, Pérez, Pilar, Gabarró, Lourdes, Orriols, María, Canet, Joan Josep, Roca, Mireia, Álvaro, Muriel, Boneu, Francesc, Giménez, Georgina, Albà, Jaume, Gibert, Francesc, Garcia, Jéssica, Barragan, Patricia, Jurado, Gustavo, Ortega, Josep Sabaté, Martínez Solano, Joan Amaurys, Fernández, Víctor, Torres, Mónica, Belén Montero Alvaredo, Ana, Redondo Parejo, Laura, Maria Aragonés, Josep, Bullón, Anna, Loste, Cora, González, Paula, Bejarano, Neker, Sanchez, Francisco, Lucchetti, Gianni, Pla, Xavier, Gimeno, Javier, Reynaga, Esteban, Barcons, Montse, Celedón, Gabriel, Ortiz, Juan, Anastasovski, Goran, Mascaró, Oscar, de los Ríos, Javier Diez, Feliu, Meritxell, Ribera, Anna, Ruiz, Cristhian, Corominas, Gerard, Nunes, Daniella, Roca, Claudia, Latorre, Nadina, Yataco, Lizbeth, Cruz, Maricelys, Blanco, Nerea, Castejón, Santiago, Calderón, Dolores Cocho, Sunyer, Claustre Pont, Garcia, Jordi Espinosa, Martin, Rodrigo Paz, de Luis Sanchez, Albert, Vivas, Dolores Espinosa, Molina, Juan Valencia, Gemma, Palome, Planels, Chaume, Laia Tomas, Vilella, Ares Villagrasa, Bustamante, Marco, Boltes, Anunciación, Rodríguez, Fernando, Arrieta, Itziar, Ciurans Molist, Jordi, Andreu, Barnés, Soler, Ernest Palomeras, Buscà, Nicolau Guanyabens, López, Manuel Daza, Farreres, Jordi Bigas, Ruiz, Virginia Casado, Batiste, Desiree Muriana, Sanz Cartagena, Mª Pilar, de Vega, Eulalia Cabot, Real, Josep Bassa, Roman, Hector Pelaez, Socolich, César, Alonso Camp, Josep Mª, Cano Orgaz, Antonio Tomás, Fossas Felip, Mª Pilar, Morón, Nicolás, Bacca, Sandra, Molina, Mauricio, Casarramona, Francesc, Elias, Lorena, Bukaei, Muhammad Zidane, Martos Gutierrez, Jose Antonio, Escuin, Judith Lopez, Olaizola, Cristina, Vargas, Yolexis López, Jiménez Oyonarte, Juan, Soultana, Rashida, Golpe, Eduardo Sanjurjo, Salvador, Esther, Vila, Guillem, Serrano, Marcos, López Claverol, Matilde Nuria, Lamolla, Marian, Amate, Miquel, Rodriguez, Adriana, Romero, Ruth, del Carpio, Montgomery, Hernandez, Ana Isabel, Martín, Julián, Rosas, M Carmen, Nogueroles, Antonio, Encarnación, Sorilandy, Robles, Augusto, Herrera, Jose Antonio, Gavilán, Roger, Mameghani, Toghrol, Araujo, Gastón, Garrido Morales, M.Angeles, Albert Segui, Enric Ramon, Climent, Eva Fernandez, Pujol, Francesc Paris, Garrofé Seira, Mireia Judit, Pía, Lucía Gómez, Nuñez, Fernando Salleres, Peñalver, Cristina Aguar, Lopes, Cristina Vaz, Ribera Tasa, Elisenda, Vilchez, Carmen Repullo, Zambrana, Modesto Sánchez, Ribas, Beatriu Suescun, Panés, Inés Vilà, Planavila, Montserrat Vila, Lorenzo, Alicia Vaqueiro, Guixes, Meritxell Sabartés, Medina, Jorge, Sambrano, David, Zamarreño, Javi, Pirela, Carmen, Vélez, Paola, Cajamarca, Luis, Pérez, Honey, Martínez, Yarles, Alexander Gonçalves, Jesus, Regordosa, Carles, Mormeneo, Claudia, Griu, Laura, Francia Colina, Maria, Farik, Enric, Duch, Dolors Carrión, Badenas, Carles, Bernal, Oscar, Agramunt, Núria, Morales, Shyrlei, Reynoso, Victoria, Guerrero, Miguel, Romera Cid, Primitivo, Folqué, Mònica, Pedroza, Claudia, Hachem, Adnan, Martínez, Íñigo Soteras, Verdera García, Xavier, Amorós, Mercè López, Subirós, Xavier Costa, Benet, Marta Cufí, Van Eendenburg, Cecile, Osuna, Teresa, Santos, Dra Gina, Pallisera, Mireia, Oliva, Lluís Gonzalo, Sanchez, Gemma, Basurto, Xavier, Vivoda, Ludgi, Van der Kleyn, Richard, Robles, Laura, Cabanelas Barranco, Ana, Almendros, Mª Cruz, Oliveras, Marc Pérez, Álvarez, Amelia Fernández, Rybyeva, Maria, Viñas, Antoni, Barcons, Maria, Alberto Tavera, Joaquim Danès, Burbano, Pablo, López, Cintie, Cruz, David, Bisbe, Paula, Fernández, Nora, Carlos Palacio, Juan, Fraiz, Eduardo, Aguiló, Oriol, Amorodjo, Rollmy, Velázquez, John, Sánchez, Elena, Español, Jaume, de Celis, Judit Perez, Coll, Anna, Díaz, Glòria, Vergés i Sala, Margarida, Casas Capdevila, Mª Ángels, Ferrini, Yosmairy Yoselin, Gorriz, Aitor, Cucurell Navarro, Diego-Javier, Velásquez, Dulce, Pla Soler, Jaume, González, Josep, Higuera, Julian David, Cuellar, Lina, Miniello, Liza Margarita, Pujol, Lluis, Cracan, Sorin, Vives, Mora, Angela, M, Lopez, Lopez, Anabel, Molist, Montse Gorchs, Anna, Delofeu, Muñoz, Silvia Solà, Yolanda, Ferreres, Pujalte, Carol, Téllez Marín, Elisabeth, Font Casas, Yolanda, Hernández Luque, Sara, Sendra, Joaquim Mejias, Valero, Francesca Mellado, Escala, Campos, Lacanal, Galup De, Diaz, Lopez, Paramio, Castillo, Estopà, Català, Moreda, Español, Majo, Calafell, Almeida, Carballo, Naval, Castro, Elena, M, Ruiz, Cregut, Lluis, Pere, Font, Deulofeu, Sanjuan, Fabregat, Pere, Joan, Gorchs, Fontquerni, Bellés, Forés, Antoni, Joan, Herrera, Gomez, Carlos, Juan, Prades, Hijazo, Torvisco, Itzaina, Rovira, Marti, Gonzalez, Obiols, Cavero, Olive, Gil, Querol, Soledad, M, Rodriguez, Rico, Sambernardo, Rios, Molina, Ropero, Ramon, Jose, Valero, Sanchez, Arevalo, Santos, Jose, Maria, Garcia, Soto, Angeles, Maria, Escribano, Tebar, Garcia, Torres, José, Pedro, Carrion, Verdes, Isabel, M, Lopez, Verge, Jose, Juan, Canela, Lopez, Angeles, M, Guarque, Lucas, Alvarez, Morales, Arnulfo, Jorge, Fornieles, Morell, Gomez, Subirats, Teresa, Maria, Masa, Torello, Lopez, Val, Mercedes, Maria, Reyes, Palmero, Manuel, Juan, Forne, Rodriguez, Turiel, Ruana, Gonzalez, Sanchez, Gornals, Sebastia, Rico, Abrio, Falip, Albert Gual, Oliveros, Aznar, Perotti, Brugues, Molinero, Calvet, Franco, Catells, Medina, Corrales, Miro, Daroca, Marquez, Duran, Pradas, Feliu, Casanova, Figueras, Tortajada, Garcia, Gallego, Grajera, del Mar, Azahara, Arroyo, Las, de Jesus, Dulcenombre, Sanz, Laserreta, Vidal, Llambrich, Corral, Monllao, de la Cruz, Morales, Blanco, Moreno, Orgaz, Orejuela, Suazo, Piñana, Minguillon, Pons, Gómez, Rodríguez, Carlos, José, Pereira, Rodriguez, Porcel, Sedo, Villar, Sevil, Lopez, Sierra, Romero, Torres, Calveres, Trepat, Arnella, Ventura, Gil, Acera, Teresa, M, Vico, Biesot, Galea, Castro, Maria, Rosa, Chafer, Escorcia, Antonio, Juan, Moreda, Español, Faure, Gil, Luque, Hernandez, Delgado, Jimenez, Gay, Mallafre, Angel, M., Sanzo, Olivares, Fondevila, Pubill, Fort, Sabate, Agámez, Segovia, Carlos, Antonio, Longaretti, Turata, Hernandez, Valle, Guixens, Trayner, Valor, Aguilar, Alvarez, Aguirre, Naval, Alastrue, Baquero, Alferez, Marne, Alonso, Cristina, Orozco, Aloy, Colino, Alvarez, Peñuela, Alvarez, Cirilo, Ameller, Vanessa, Maria, Guerrero, Andujar, Remedios, Estefania, Sillero, Auladell, Sorbet, Azcarate, Genesca, Basany, Barduena, Benavent, Tudela, Benito, Pardo, Blanch, Pla, Boluda, Gonzalez, Bonilla, Serramalera, Bru, Andreu, Burnat, Calvo-Rayo, Caballero, Casellas, Calvo, Mombiela, Camps, Bresme, Cano, Fernandez, Carcelen, Solà, Caro, Matavacas, Casasas, Bolado, Castanedo, Cortina, Cerdeña, Jane, Abella, Collado Borrego, Laia, Orri, Colom, Vilanova, Comellas, Sole, Conillera, Torres, Cots, Estepa, Cuchi, Graell, de Sostoa, Lopez, del Rio, Compte, Delgado, Bueno, Diaz, Maneiro, Diaz, Lucia, Andrea, Palau, Domenech, Carme, M., Carasso, Duran, Javier, Pablo, Marquez, Duran, Abidi, El, Martin, Escoda, Casanovas, Esteve, Perez, Fernandez, Quintero, Ferre, Escobar, Flores, Abad, Fontcuberta, del Valle, Fortes, Luisa, Mª, Quesada, Franco, Maria, Sara, Romero, Franco, Teresa, Maria, Francisco, Gallego, Gala, Gamiz, Alicia, Castañeda, Garcia, Rodriguez, Garcia, Gemma, Casajuana, Arroyo, Gomez, Girbau, Gomez, Fernandez, Gonzalez, Gonzalez, Gonzalez, Gonzalez, Gonzalez, Lopez, Gonzalez, Obeso, Gual, Blanco, Guerrero, Roca, Guillemas, Eudaldo, Guillermo, Sebastia, Hernandez, Covas, Homar, Alvarez, Hostench, Royo, Huerta, Barcelo, Ibañez, Cruz, Izquiero, Urdangarin Etxetxikia, Jaione, Gimenez, Juárez, Alami, Khlifi, Gasco, Laparra, Moreales, Lara, Arroyo, Las, de Jesus, Dulcenombre, Medina, Lasaosa, Lourdes, Maria, Cava, Lazaro, Berrar, Leon, Maturana, López, Ramirez, Lopez, Romero, López, Marco, Lorente, Martin, Lorenzo, Casals, Lozano, Nicola, Lujan, Diaz, Madrid, Antonio, Jose, Peris Morales, Maria Teresa, Clemente, Marti, Castaño, Martinez, Natanael, David, Gamez, Martinez, Gonzalez, Martinez, Quesada, Martinez, de la Cabeza, Maria, Fusté, Marzà, Mireia, Conillera, M, Lasheras, Melendo, Mestre, Miralles, Puig Pastalle, Montserrat, Vidal, Montserrate, Mellado, Mora, Ponce, Morales, Fornieles, Morell, Cabre, Morera, Vivet, Morera, Souza, Mundi, Quiles, Muñoz, Rosa, Navea, Iglesias, Neira, Asuncion, M, Manrique, Nuñez, Pilar, Mª, Martinez, Obiols, Reig, Pallares, Torres, Partegas, Berengueras, Pascual, Gamez, Perez, Oset, Perez, Restrepo, Perez, Alejandra, Maria, Yeste, Planas, Mangado, Planells, Minguillon, Pons, Carbonell, Puertas, Blanco, Quinteiro, Benavente, Rebollar, Fernandez, Recasens, Gomez, Reyes, del Carmen, Maria, Pou, Roca, Ferrer, Rodriguez, Franco, Rodriguez, Fuertes, Rodriguez, Muñoz, Rodriguez, Navarro, Rodriguez, Iniesta, Roig, Gracia, Romero, Brunet, Rovira, de Eugenio, Rovira, Baena, Rubio, Llorens, Ruiz, Llamazares, Sala, Alaez, San Juan, Segura, Sanchez, Soldevilla, Santasusana, Salmeron, Sanz, Perez, Segura, Balcells, Serra, Dumitras, Sorina, Montoya, Teixidor, Vicente, Tena, Salinas, Tierno, Ines, Ester, Testa, Toledo, Figueras, Tomàs, Ruperez, Tomas, Garcia-Penche, Torrano, Esparza, Torres, Uku, Florenc, Blanco, Vazquez, De la Paz, Vazquez, Gil, Vazquez, Gonzalez, Vazquez, Meler, Vidal, Cots, Vilalta, Jimenez, Vilches, Jose, Maria, Fernandez, Visser, Gavin, Viu, Vives, Vives, Jimenez, Carmona, Jose, Francisco, Vilches, Galobardes, Gomez, Gonzalez, Manzanera, Jodar, Cortes, Marimon, Orive, Marrodan, Bosch, Martin, Jose, Maria, Lopez, Martorell, Roca, Millares, Jesus, M, Guri, Miralles, Hernandez, Muliterno, Oliva, Muñoz, Pujol, Pons, Conde, Postius, Arruñada, Prieto, Antonio, Jose, Mathé, Quintana, Mata, Rosell, Alvarez, Aguirre, Alvarez, Alvarin, Flores, Arrufat, Pago, Bañuelos, Andreu, Burnat, Vilar, Campo, Hidalgo, Cardus, Gil, Castello, Gloria, Maria, Montsesinos, Castrillo, Estopà, Català, Garces, Clave, Sanroma, Comes, Sequi, Descalzo, Ricol, Errando, Campillo, Escudero, del Mar, Maria, Alvarez, Fernandez, Gomez, Fernandez, Perez, Fernandez, Espinosa, Franch, Graells, Freixes, Plaza, Garcia, Gallego, Garcia-Marron, Simancas, Hernandez, Covas, Homar, Royo, Huerta, Armas, Jaraba, Ramos, Jimenez, Canela, Lopez, Angeles, M, Lopez, Lopez, Oganissian, Lopez, Romero, Madrona, Rosa, M, Millan, Martinez, Morón, Martínez, Encinas, Merchan, Fornieles, Morell, Jimenez, Moreno, Rico, Muñoz, Rodriguez, Navarro, Ibañez, Nogales, Maria, Rita, Viera, Novillo, Torrabadella, Parella, Alba, Mari, Villar, Pera, Montserrat, Carla, Carbonell, Puertas, Miralles, Rabella, Trilles, Ramis, Ortiz, Ribera, Fuertes, Rodriguez, Gonzalez, Sanchez, Perez, Sastre, Perez, Segura, Borrega, Soro, Garcia, Soto, Angeles, Maria, Fores, Tapia, Bernad, Tellez, Alvarez, Trenado, Moreda, Español, Martin, Felix, Perez, Herrero, Manzanera, Jodar, Fuster, Lanau, Gomariz, Lopez, Orive, Marrodan, Bosch, Martin, Jose, Maria, Guri, Miralles, Oliva, Muñoz, Lozano, Pardo, Pujol, Pons, Altimiras, Quintana, Lopez, Ventosa, Damian, Almodovar, Colino, Alvarez, Monterroso, Alvarez, Comas, Arambudo, Garzon, Boullon, Capella, Burgos, Garcia, Campuzano, Del Mar, Maria, Olivas, Capdevila, Fernandez, Carcelen, Solà, Caro, Marti, Carre, Isabel, Clara, Bacaicoa, Carretero, Gil, Castello, Gloria, Maria, Montsesinos, Castrillo, Calderon, Cazorla, Osuna, Chacon, Planas, Cortes, Olio, Cortit, Estany, Delhomme, Carasso, Duran, Javier, Pablo, Campillo, Escudero, del Mar, Maria, Martinez, Fructuos, Lopez, Garcia, Luis, Pascual, Plaza, Garcia, Amill Vallve, Genis, Arroyo, Gomez, Girbau, Gomez, Muñoz, Gonzalez, Ventura, Hernaez, Covas, Homar, Gimenez, Lavernia, Rojo, Martin, Medina, Martínez, Millan, Martinez, Barrera, Mayol, Pi, Mercader, Dalmau, Merino, Campodarbe, Miguel, Pastalle, Montserrat Puig, de la Cruz, Morales, Fornieles, Morell, Sanchez, Moreno, Javier, Francisco, Reig, Pallares, Torrabadella, Parella, Mari, Alba, Barrameda, Penela, Ajenjo, Prieto, Benavente, Rebollar, Pareja, Rodriguez, Piñar, Rodríguez, Francisco, Javier, Tello, Rodriguez, Pereda, Romero, Saborido, Sainz, Martin, Santacana, Martinez, Santos, Chavez, Sierra, Testa, Toledo, Figueras, Tomàs, Garcia, Torres, José, Pedro, Torres, Turbau, Domenech, Vicente, Esteo, Villena, Pertegaz, Vives, Gonzalez, Baena, Pont, Bagaria, Sanchez, Beltran, Alarcon, Bonet, Ballescà, Borch, Clanchet, Buhils, Garcia, Closa, Carril, Colomina, Sanchez, Cristina Fernandez, Edurne Judith, Fernandez Toledo, Rodriguez, Espases, Resa, Espert, Xavier, F, Sol, Fernández, Lugo, Gonzalez, Llesera, Gracia, Lendinez, Herrada, Liesa, Juliench, Alicia, Sandra, Ortega, Lopez, Yuste, Lopez, Villanueva, Lozano, Soto, Lucia Sola, Castellano, Madrid, Cano, Megias, Jesus, Daniel, Ponce, Montasell, Sospedra, Montesinos, Martinez, Moya, Herrera, Muñoz, Isabel, M, Fernandez, Ocaña, Jose, Maria, Bernal, Palau, Sole, Perez, Carbonell, Ramon, Lop, Ribas, López, Rubio, Lopez, Rueda, Castaño, Sabat, Lara, Sabata, Ramírez, Salmerón, Gornals, Sebastia, Creus, Serra, Dalmau, Serrano, Mainero, Sumasi, Gabriel, Gonzalo, Masa, Torello, Primo, Valencia, Viñuales Muñoz, Ana Maria, Roig, Josep, and Hidalgo., Verònica
Published: 2022
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55. Biological Signatures of Asymptomatic Extra- and Intracranial Atherosclerosis: The Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) Study

Author: López-Cancio, Elena, Galán, Amparo, Dorado, Laura, Jiménez, Marta, Hernández, María, Millán, Mónica, Reverté, Silvia, Suñol, Anna, Barallat, Jaume, Massuet, Anna, Alzamora, Maria Teresa, Dávalos, Antonio, and Arenillas, Juan Francisco
Published: 2012
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56. Sex-Specific Protective Effects of APOE ε2 on Cognitive Performance

Author: Lamonja-Vicente, Noemí, primary, Dacosta-Aguayo, Rosalia, additional, López-Olóriz, Jorge, additional, Prades-Senovilla, Laia, additional, Roig-Coll, Francesca, additional, Castells-Sánchez, Alba, additional, Soriano-Raya, Juan José, additional, Clemente, Inmaculada, additional, Miralbell, Júlia, additional, Barrios, Maite, additional, López-Cancio, Elena, additional, Cáceres, Cynthia, additional, Arenillas, Juan Francisco, additional, Millán, Mónica, additional, Torán, Pere, additional, Pera, Guillem, additional, Fores, Rosa, additional, Alzamora, Maria Teresa, additional, Mataró, Maria, additional, and Via, Marc, additional
Published: 2020
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57. Efficacy and Safety of Endovascular Treatment in Acute Tandem Carotid Occlusions: Analysis of a Single-Center Cohort

Author: Fernández Menéndez, Santiago, primary, Murias Quintana, Eduardo, additional, Vega Valdés, Pedro, additional, Morales Deza, Edison, additional, López-Cancio, Elena, additional, Benavente Fernández, Lorena, additional, González Delgado, Montserrat, additional, Rico-Santos, Maria, additional, Calleja Puerta, Sergio, additional, and Larrosa Campo, Davinia, additional
Published: 2020
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58. The Metabolic Syndrome Is Associated With a Higher Resistance to Intravenous Thrombolysis for Acute Ischemic Stroke in Women Than in Men

Author: Arenillas, Juan F., Sandoval, Patricio, de la Ossa, Natalia Pérez, Millán, Mónica, Guerrero, Cristina, Escudero, Domingo, Dorado, Laura, López-Cancio, Elena, Castillo, José, and Dávalos, Antoni
Published: 2009
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59. LOS ICTUS SÍ SE PUEDEN PREVENIR.

Author: LÓPEZ-CANCIO, ELENA
Published: 2022

60. Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain

Author: International Stroke Genetics Consortium, Consorcio español de genética del ictus, Redes Temáticas de Investigación Cooperativa en Salud (España), Cullell, Nàtalia, Carrera, Caty, Muiño, Elena, Torres-Águila, Nuria P., Cárcel-Márquez, Jara, González-Sánchez, Jonathan, Gallego-Fabrega, Cristina, Molina, Jessica, Besora, Sarah, Sotoca, Javier, Buongiorno, Maria Teresa, Jiménez-Conde, Jordi, Giralt-Steinhauer, Eva, Torres-Chacón, Reyes de, Montaner, Joan, Mancha, Fernando, Cabezas, Juan A., Marti-Fabregas, Joan, Prats-Sánchez, Luis, Camps-Renom, Pol, Purroy, Francisco, Cambray, Serafí, Freijo, Mar, Vives-Bauzá, Cristòfol, Tur, Sílvia, Font, Maria A., López-Cancio, Elena, Hernández-Pérez, María, Obach, Víctor, Calleja, Ana, Arenillas, Juan F., Rodríguez-Yáñez, Manuel, Castillo, José, Sobrino, Tomás, Fernández-Cadenas, Israel, Krupinski, Jerzy, International Stroke Genetics Consortium, Consorcio español de genética del ictus, Redes Temáticas de Investigación Cooperativa en Salud (España), Cullell, Nàtalia, Carrera, Caty, Muiño, Elena, Torres-Águila, Nuria P., Cárcel-Márquez, Jara, González-Sánchez, Jonathan, Gallego-Fabrega, Cristina, Molina, Jessica, Besora, Sarah, Sotoca, Javier, Buongiorno, Maria Teresa, Jiménez-Conde, Jordi, Giralt-Steinhauer, Eva, Torres-Chacón, Reyes de, Montaner, Joan, Mancha, Fernando, Cabezas, Juan A., Marti-Fabregas, Joan, Prats-Sánchez, Luis, Camps-Renom, Pol, Purroy, Francisco, Cambray, Serafí, Freijo, Mar, Vives-Bauzá, Cristòfol, Tur, Sílvia, Font, Maria A., López-Cancio, Elena, Hernández-Pérez, María, Obach, Víctor, Calleja, Ana, Arenillas, Juan F., Rodríguez-Yáñez, Manuel, Castillo, José, Sobrino, Tomás, Fernández-Cadenas, Israel, and Krupinski, Jerzy
Abstract: Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 previously associated with acenocoumarol maintenance dose in a Genome-Wide Association study (GWAs) in Dutch population are associated with stroke recurrence, intracranial haemorrhage (ICH) and acenocoumarol maintenance dose in a Spanish population. We performed a GWAs using Human Core Exome-chip (Illumina) in 78 patients stroke patients treated with acenocoumarol for secondary prevention enrolled as part of the prospective investigator-initiated study (IIS) SEDMAN Study. Patients were followed-up a median of 12.8 months. Three and eight patients had recurrent stroke and ICH events, respectively. We found 14 of the 49 published variants associated with acenocoumarol maintenance dose (p < 0.05). Six polymorphisms were associated with stroke recurrence and four variants with ICH (p < 0.05). In conclusion, variants in VKORC1 and CYP2C9 are associated with acenocoumarol maintenance dose, stroke recurrence and ICH in a Spanish cohort. These results highlight the relevance of studying pharmacogenetics associated with efficacy and safety of anticoagulant drugs and justify studies with larger sample size and different ethnic populations.
Published: 2020

61. Impact of COVID‐19 outbreak in reperfusion therapies of acute ischemic stroke in North‐West Spain

Author: Tejada Meza, Herbert [0000-0002-6506-1037], Lambea-Gil, Álvaro [0000-0003-1785-9201], Navarro Pérez, María Pilar [0000-0001-6370-218X], Tejada Meza, Herbert, Lambea-Gil, Álvaro, Sancho Saldaña, Agustín, Martínez-Zabaleta, Maite, Garmendia Lopetegui, Eñaut, López-Cancio, Elena, Castañón Apilánez, María, Herrera Isasi, María, Marta Enguita, Juan, Gómez-Vicente, Beatriz, Arenillas, Juan F., Arenaza Basterrechea, Naroa, Timiraos Fernández, Juan José, Sánchez, Joaquín, Maciñeiras Montero, José Luis, Castellanos-Rodrigo, Mar, Fernández‐Coud, Dolores, Casado Menéndez, Ignacio, Temprano Fernández, María Teresa, Freijo, Mar, Luna, Alain, Palacio Portilla, Enrique, Jiménez López, Yésica, Rodríguez Castro, Emilio, Rodríguez‐Yáñez, Manuel, Tejada García, Javier, Beltrán Rodríguez, Iria, Julián-Villaverde, Francisco, Moreno García, María Pilar, Trejo-Gabriel-Galán, José María, Echavarría Iñiguez, Ana, Pérez Lázaro, Cristina, Navarro Pérez, María Pilar, Marta Moreno, Javier, Tejada Meza, Herbert [0000-0002-6506-1037], Lambea-Gil, Álvaro [0000-0003-1785-9201], Navarro Pérez, María Pilar [0000-0001-6370-218X], Tejada Meza, Herbert, Lambea-Gil, Álvaro, Sancho Saldaña, Agustín, Martínez-Zabaleta, Maite, Garmendia Lopetegui, Eñaut, López-Cancio, Elena, Castañón Apilánez, María, Herrera Isasi, María, Marta Enguita, Juan, Gómez-Vicente, Beatriz, Arenillas, Juan F., Arenaza Basterrechea, Naroa, Timiraos Fernández, Juan José, Sánchez, Joaquín, Maciñeiras Montero, José Luis, Castellanos-Rodrigo, Mar, Fernández‐Coud, Dolores, Casado Menéndez, Ignacio, Temprano Fernández, María Teresa, Freijo, Mar, Luna, Alain, Palacio Portilla, Enrique, Jiménez López, Yésica, Rodríguez Castro, Emilio, Rodríguez‐Yáñez, Manuel, Tejada García, Javier, Beltrán Rodríguez, Iria, Julián-Villaverde, Francisco, Moreno García, María Pilar, Trejo-Gabriel-Galán, José María, Echavarría Iñiguez, Ana, Pérez Lázaro, Cristina, Navarro Pérez, María Pilar, and Marta Moreno, Javier
Abstract: Since the first reported case in early December 2019, severe acute respiratory coronavirus 2 (SARS‐CoV‐2) infection, known as Coronavirus Disease 2019 (COVID‐19), has spread all over the world (1‐3). As of June 4th, more than 6 million cases and 350,000 deaths have been reported worldwide (4). Treating these patients and containing the outbreak has become the main priority in any center, arising the risk of possible collateral damage on patients with other acute diseases due to the collapse of the pre‐ and intra‐hospital emergency care systems.
Published: 2020

62. Impact of COVID-19 outbreak on ischemic stroke admissions and in-hospital mortality in North-West Spain

Author: Tejada Meza, Herbert [0000-0002-6506-1037], Lambea-Gil, Álvaro [0000-0003-1785-9201], Arenillas, Juan F. [0000-0001-7464-6101], Trejo-Gabriel-Galán, José María [0000-0001-9591-8452], Tejada Meza, Herbert, Lambea-Gil, Álvaro, Sancho Saldaña, Agustín, Martínez-Zabaleta, Maite, Riva Juez, Patricia de la, López-Cancio, Elena, Castañón Apilánez, María, Herrera Isasi, María, Marta Enguita, Juan, Lera Alfonso, Mercedes de, Arenillas, Juan F., Segurola Olaizola, Jon, Timiraos Fernández, Juan José, Sánchez, Joaquín, Castellanos-Rodrigo, Mar, Roel, Alexia, Casado Menéndez, Ignacio, Freijo, Mar, Luna, Alain, Palacio Portilla, Enrique, Jiménez López, Yésica, Rodríguez Castro, Emilio, Arias Rivas, Susana, Tejada García, Javier, Beltrán Rodríguez, Iria, Julián-Villaverde, Francisco, Moreno García, María Pilar, Trejo-Gabriel-Galán, José María, Echavarría Iñiguez, Ana, Tejero Juste, Carlos, Pérez Lázaro, Cristina, Marta Moreno, Javier, Tejada Meza, Herbert [0000-0002-6506-1037], Lambea-Gil, Álvaro [0000-0003-1785-9201], Arenillas, Juan F. [0000-0001-7464-6101], Trejo-Gabriel-Galán, José María [0000-0001-9591-8452], Tejada Meza, Herbert, Lambea-Gil, Álvaro, Sancho Saldaña, Agustín, Martínez-Zabaleta, Maite, Riva Juez, Patricia de la, López-Cancio, Elena, Castañón Apilánez, María, Herrera Isasi, María, Marta Enguita, Juan, Lera Alfonso, Mercedes de, Arenillas, Juan F., Segurola Olaizola, Jon, Timiraos Fernández, Juan José, Sánchez, Joaquín, Castellanos-Rodrigo, Mar, Roel, Alexia, Casado Menéndez, Ignacio, Freijo, Mar, Luna, Alain, Palacio Portilla, Enrique, Jiménez López, Yésica, Rodríguez Castro, Emilio, Arias Rivas, Susana, Tejada García, Javier, Beltrán Rodríguez, Iria, Julián-Villaverde, Francisco, Moreno García, María Pilar, Trejo-Gabriel-Galán, José María, Echavarría Iñiguez, Ana, Tejero Juste, Carlos, Pérez Lázaro, Cristina, and Marta Moreno, Javier
Abstract: Background and purpose Spain has been one of the countries heavily stricken by COVID-19. But this epidemic has not affected all regions equally. We analyzed the impact of the COVID-19 pandemic on hospital stroke admissions and in-hospital mortality in tertiary referral hospitals from North-West Spain., Methods Spanish multicenter retrospective observational study based on data from tertiary hospitals of the NORDICTUS network. We recorded the number of patients admitted for ischemic stroke between 30 December 2019 and 3 May 2020, the number of IVT and EVT procedures, and in-hospital mortality., Results In the study period, 2737 patients were admitted with ischemic stroke. There was a decrease in the weekly mean admitted patients during the pandemic (124 vs. 173, p<0.001). In-hospital mortality of stroke patients increased significantly (9.9% vs. 6.5%, p = 0.003), but there were no differences in the proportion of IVT (17.3% vs. 16.1%, p = 0.405) or EVT (22% vs. 23%, p = 0.504)., Conclusion We found a decrease in the number of ischemic stroke admissions and an increase in in-hospital mortality during the COVID-19 epidemic in this large study from North-West Spain. There were regional changes within the network, not fully explained by the severity of the pandemic in different regions.
Published: 2020

63. Structural brain changes and cognition in relation to markers of vascular dysfunction

Author: Miralbell, Julia, Soriano, Juan José, Spulber, Gabriela, López-Cancio, Elena, Arenillas, Juan Francisco, Bargalló, Núria, Galán, Amparo, Barrios, Maria Teresa, Cáceres, Cynthia, Alzamora, Maria Teresa, Pera, Guillem, Kivipelto, Miia, Wahlund, Lars-Olof, Dávalos, Antoni, and Mataró, Maria
Published: 2012
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64. A Genome-Wide Meta-Analysis

Author: Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Nàtalia, Torres-Águila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernández-Guillamón, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Marti-Fabregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Víctor, Ribó, Marc, Molina, Carlos A., Álvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kistiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi, Fundació La Marató de TV3, Instituto de Salud Carlos III, National Institutes of Health (US), and National Institute of Neurological Disorders and Stroke (US)
Subjects: Allele, Genome-wide association study, Ischemic stroke, Genetic loci, cardiovascular diseases, Genetic variant
Abstract: [Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome., [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date., [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9)., [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci., Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.
Published: 2019

65. Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain

Author: Cullell, Natalia, primary, Carrera, Caty, additional, Muiño, Elena, additional, Torres-Aguila, Nuria-Paz, additional, Cárcel-Márquez, Jara, additional, González-Sánchez, Jonathan, additional, Gallego-Fabrega, Cristina, additional, Molina, Jessica, additional, Besora, Sarah, additional, Sotoca, Javier, additional, Buongiorno, Maria-Teresa, additional, Jiménez-Conde, Jordi, additional, Giralt-Steinhauer, Eva, additional, de Torres-Chacón, Reyes, additional, Montaner, Joan, additional, Mancha, Fernando, additional, Cabezas, Juan A, additional, Martí-Fàbregas, Joan, additional, Prats-Sánchez, Luis, additional, Camps-Renom, Pol, additional, Purroy, Francisco, additional, Cambray, Serafi, additional, Freijo, María del Mar, additional, Vives-Bauzá, Cristòfol, additional, Tur, Silvia, additional, Font, Maria-Àngels, additional, López-Cancio, Elena, additional, Hernandez-Perez, Maria, additional, Obach, Victor, additional, Calleja, Ana, additional, Arenillas, Juan, additional, Rodríguez-Yáñez, Manuel, additional, Castillo, José, additional, Sobrino, Tomas, additional, Fernández-Cádenas, Israel, additional, and Krupinski, Jerzy, additional
Published: 2020
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66. Third Ventricle Width Assessed by Transcranial Sonography as Predictor of Long-Term Cognitive Impairment

Author: Crespo-Cuevas, Ane Miren, primary, López-Cancio, Elena, additional, Cáceres, Cynthia, additional, González, Anna, additional, Ispierto, Lourdes, additional, Hernández-Pérez, María, additional, Mataró, María, additional, Planas, Anna, additional, Canento, Tamara, additional, Martín, Lorena, additional, Arenillas, Juan Francisco, additional, Alvarez, Ramiro, additional, and Vilas, Dolores, additional
Published: 2020
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67. A Genome-Wide Meta-Analysis

Author: Mola-Caminal, Marina, Carrera, Caty, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Díaz-Navarro, Rosa M., Tur, Sílvia, Jiménez, Carmen, Medina-Dols, Aina, Cullell, Nàtalia, Torres-Águila, Nuria P., Muiño, Elena, Rodríguez-Campello, Ana, Ois, Ángel, Cuadrado-Godia, Elisa, Vivanco-Hidalgo, Rosa M., Hernández-Guillamón, Mar, Solé, Montse, Delgado, Pilar, Bustamante, Alejandro, García-Berrocoso, Teresa, Mendióroz, Maite, Castellanos, Mar, Serena, Joaquín, Marti-Fabregas, Joan, Segura, Tomás, Serrano-Heras, Gemma, Obach, Víctor, Ribó, Marc, Molina, Carlos A., Álvarez-Sabín, José, Palomeras, Ernest, Freijo, Mar, Font, Maria A., Rosand, Jonathan, Rost, Natalia S., Gallego-Fabrega, Cristina, Lee, Jin-Moo, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Phuah, Chia-Ling, Lemmens, Robin, Thijs, Vincent, Lindgren, Arne, Maguire, Jane, Rannikmae, Kistiina, Sudlow, Catherine L., Jern, Christina, Stanne, Tara M., Lorentzen, Erik, Muñoz-Narbona, Lucía, Dávalos, Antonio, López-Cancio, Elena, Worrall, Bradford B., Woo, Daniel, Kittner, Steven J., Mitchell, Braxton D., Montaner, Joan, Roquer, Jaume, Krupinski, Jurek, Estivill, Xavier, Rabionet, Raquel, Vives-Bauzá, Cristòfol, Fernández-Cadenas, Israel, Jiménez-Conde, Jordi, Fundació La Marató de TV3, Instituto de Salud Carlos III, National Institutes of Health (US), and National Institute of Neurological Disorders and Stroke (US)
Subjects: genetic variant, genome-wide association study, Tight Junction Proteins, allele, Stroke Rehabilitation, genetic loci, Recovery of Function, Polymorphism, Single Nucleotide, Brain Ischemia, Stroke, Disability Evaluation, Phenotype, Treatment Outcome, Gene Frequency, Risk Factors, ischemic stroke, Humans, Genetic Predisposition to Disease, Genome-Wide Association Study
Abstract: [Rationale] Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. [Objective] Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date. [Methods and Results] A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10−9). [Conclusions] Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci. Genetic contribution to functional outcome and disability after stroke (GODS) project, Fundació Marató-TV3 Grant 2011 (76/C/2011), Recercaixa’13; Generación Project, Instituto de Salud Carlos III; GENISIS (Genetics of Early Neurological InStability After Ischemic Stroke) project, National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke Stroke Genetics Network (SiGN) Project, NIH.
Published: 2018

68. The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA): rationale and design

Author: Pera Guillem, Alzamora Maite, Galán Amparo, Mataró María, Massuet Anna, Suñol Anna, Reverté Silvia, Millán Mónica, Dorado Laura, López-Cancio Elena, Torán Pere, Dávalos Antoni, and Arenillas Juan F
Subjects: Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract Background Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona-ASymptomatic Intracranial Atherosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition. Methods/Design Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. Discussion The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition.
Published: 2011
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69. Delayed Neurological Improvement After Full Endovascular Reperfusion in Acute Anterior Circulation Ischemic Stroke.

Author: Talavera, Blanca, Gómez-Vicente, Beatriz, Martínez-Galdámez, Mario, López-Cancio, Elena, García-Cabo, Carmen, Castellanos, Mar, Roel, Alexia, Tejada-Meza, Herbert, Marta-Moreno, Javier, Pérez-Lázaro, Cristina, Pilar Navarro-Pérez, María, Bravo-Anguiano, Yolanda, Bártulos-Iglesias, Mónica, Tejada-García, Javier, Rodrigo-Stevens, Gabriela, Martínez-Zabaleta, Maite, de la Riva, Patricia, José Timiraos-Fernández, Juan, del Mar Freijo, María, and Luna, Alain
Published: 2021
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70. Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke

Author: Torres-Águila, Nuria P., Carrera, Caty, Giese, Anne-Katrine, Cullell, Nàtalia, Muiño, Elena, Cárcel-Márquez, Jara, Gallego-Fabrega, Cristina, González-Sánchez, Jonathan, Freijo, Mar, Álvarez-Sabín, José, Molina, Carlos A., Ribó, Marc, Jiménez-Conde, Jordi, Roquer, Jaume, Sobrino, Tomás, Campos-Rodríguez, Francisco, Castillo, José, Muñoz-Narbona, Lucía, López-Cancio, Elena, Dávalos, Antonio, Díaz-Navarro, Rosa M., Tur, Sílvia, Vives-Bauzá, Cristòfol, Serrano-Heras, Gemma, Segura, Tomás, Krupinski, Jerzy, Delgado-Mederos, Raquel, Marti-Fabregas, Joan, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Rost, Natalia S., Montaner, Joan, Torres-Águila, Nuria P., Carrera, Caty, Giese, Anne-Katrine, Cullell, Nàtalia, Muiño, Elena, Cárcel-Márquez, Jara, Gallego-Fabrega, Cristina, González-Sánchez, Jonathan, Freijo, Mar, Álvarez-Sabín, José, Molina, Carlos A., Ribó, Marc, Jiménez-Conde, Jordi, Roquer, Jaume, Sobrino, Tomás, Campos-Rodríguez, Francisco, Castillo, José, Muñoz-Narbona, Lucía, López-Cancio, Elena, Dávalos, Antonio, Díaz-Navarro, Rosa M., Tur, Sílvia, Vives-Bauzá, Cristòfol, Serrano-Heras, Gemma, Segura, Tomás, Krupinski, Jerzy, Delgado-Mederos, Raquel, Marti-Fabregas, Joan, Heitsch, Laura, Ibáñez, Laura, Cruchaga, Carlos, Rost, Natalia S., and Montaner, Joan
Abstract: [Background and Purpose] Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke., [Methods] Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed., [Results] Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (P<5×10−8). The 14q24.3 locus was associated with acute stroke outcome (rs112809786, P=0.036) and with ACOT1 and PTGR2 gene expression. Previous polymorphisms associated with leukocyte counts in general-population did not show any significance in our study., [Conclusions] We have found the first locus associated with leukocyte counts in ischemic stroke, also associated with acute outcome. Genetic analysis of acute endophenotypes could be useful to find the genetic factors associated with stroke outcome. Our findings suggested a different modulation of immune cells in stroke compared with healthy conditions.
Published: 2019

71. Impact of Mediterranean Diet prior to Stroke on the Prognosis of Patients Undergoing Endovascular Treatment.

Author: García-Cabo, Carmen, Castañón-Apilánez, Maria, Benavente-Fernández, Lorena, Jimenez, Jose Maria, Arenillas, Juan, Castellanos, Mar, Rodrigo-Stevens, Gabriela, Tejada-Meza, Herbert, Pérez, Cristina, Martínez-Zabaleta, Maite, Rodriguez-Castro, Emilio, Sánchez, Joaquín, Julian-Villaverde, Francisco, Pinedo, Ana, Palacio, Enrique, and López-Cancio, Elena
Subjects: MEDITERRANEAN diet, ENDOVASCULAR surgery, STROKE patients, CEREBRAL infarction, STROKE, ISCHEMIC stroke, PATIENT compliance, OLIVE oil
Abstract: Introduction: Mediterranean diet (MeDiet) has been associated with lower risk of stroke. Additionally, animal models suggested that some components of MeDiet are associated with better outcomes after ischemic stroke (IS). We aimed to evaluate the association between global adherence to the MeDiet and the consumption of particular components of the MeDiet with stroke outcomes. Material and Methods: Multicenter observational study of consecutive IS patients treated with endovascular therapy. Inclusion criteria were large anterior circulation vessel occlusion and pre-stroke modified Rankin scale (mRS) <2. Adherence to MeDiet prior to stroke was evaluated using MEDAS 14-item scale. We evaluated the total score and also individual components of the scale. Clinical, radiological, and prognostic variables were collected. Good functional prognosis was considered as mRS ≤2 and complete recanalization as thrombolysis in cerebral infarction 3. Results: From January 1 to October 30, 2018, 239 patients were included (mean age 71 years, 48% women, median baseline NIHSS 16). Median MEDAS scale was 8 points (7–10). Patients with a higher adherence to MeDiet had significantly lower total and LDL-cholesterol levels. Total adherence score was not associated with stroke outcomes. In multivariate analyses, consumption of olive oil as the principal source of fat was independently associated with good functional outcome at 3 months, OR 3.2 (1.1–10.1) and daily consumption of wine was independently associated with complete recanalization, OR 2.0 (1.1–3.8). Conclusions: Our study suggests that some components of MeDiet, such as olive oil and wine consumption, are related to better prognosis after stroke. More studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]
Published: 2021
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72. Sex-Specific Protective Effects of APOE ε2 on Cognitive Performance.

Author: Lamonja-Vicente, Noemí, Dacosta-Aguayo, Rosalia, López-Olóriz, Jorge, Prades-Senovilla, Laia, Roig-Coll, Francesca, Castells-Sánchez, Alba, Soriano-Raya, Juan José, Clemente, Inmaculada, Miralbell, Júlia, Barrios, Maite, López-Cancio, Elena, Cáceres, Cynthia, Arenillas, Juan Francisco, Millán, Mónica, Torán, Pere, Pera, Guillem, Fores, Rosa, Alzamora, Maria Teresa, Mataró, Maria, and Via, Marc
Subjects: BRAIN-derived neurotrophic factor, COGNITIVE aging, C-reactive protein, APOLIPOPROTEIN E, COGNITION, SEX distribution, APOLIPOPROTEINS, GENOTYPES, LONGITUDINAL method
Abstract: Apolipoprotein E (APOE) has an important role in the multiple trajectories of cognitive aging. However, environmental variables and other genes mediate the impact of APOE on cognition. Our main objective was to analyze the effect of APOE genotype on cognition and its interactions and relationships with sex, age, lipid profile, C-reactive protein, and Brain-derived neurotrophic factor (BDNF) genotype in a sample of 648 healthy participants over 50 years of age with a comprehensive neuropsychological assessment. Our results showed that APOE ε2 carriers performed better in the Verbal Memory (p = .002) and Fluency Domains (p = .001). When we studied the effect of sex, we observed that the beneficial effect of APOE ε2 on the normalized values of these cognitive domains occurred only in females (β = 0.735; 95% confidence interval, 0.396-1.074; p = 3.167·10-5 and β = 0.568; 95% confidence interval, 0.276-0.861; p = 1.853·10-4, respectively). Similarly, the sex-specific effects of APOE ε2 were further observed on lipidic and inflammation biomarkers. In the whole sample, APOE ε2 carriers showed significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein. These differences were found only among females. Furthermore, total cholesterol and low-density lipoprotein cholesterol mediated the protective effect of APOE ε2 on cognition in the whole sample and total cholesterol in females, providing candidate physiological mechanisms for the observed genetic effects. Our results show that the neuroprotective role of APOE ε2 in cognition varies with sex and that the lipidic profile partially mediates this protection. Age-related cognitive and functional decline is a continuous biological process with different cognitive trajectories (1). Complex interactions between heritability, environmental influence, and cognitive functions in aging have been highlighted (2). In particular, genetic differences explain around 15%-25% of the variance in life expectancy (3). Therefore, the identification of susceptibility genes and their biological effects on cognitive aging is required to establish interindividual differences in this process and promote early personalized interventions to delay cognitive decline and minimize the financial burden of aging in the health care system. [ABSTRACT FROM AUTHOR]
Published: 2021
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73. Direct mechanical thrombectomy in tPA-ineligible and -eligible patients versus the bridging approach: a meta-analysis

Author: Kaesmacher, Johannes, primary, Mordasini, Pasquale, additional, Arnold, Marcel, additional, López-Cancio, Elena, additional, Cerdá, Neus, additional, Boeckh-Behrens, Tobias, additional, Kleine, Justus F, additional, Goyal, Mayank, additional, Hill, Michael D, additional, Pereira, Vitor Mendes, additional, Saver, Jeffrey L, additional, Gralla, Jan, additional, and Fischer, Urs, additional
Published: 2018
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74. Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions

Author: De Meyer, Simon F, primary, Andersson, Tommy, additional, Baxter, Blaise, additional, Bendszus, Martin, additional, Brouwer, Patrick, additional, Brinjikji, Waleed, additional, Campbell, Bruce CV, additional, Costalat, Vincent, additional, Dávalos, Antoni, additional, Demchuk, Andrew, additional, Dippel, Diederik, additional, Fiehler, Jens, additional, Fischer, Urs, additional, Gilvarry, Michael, additional, Gounis, Matthew J, additional, Gralla, Jan, additional, Jansen, Olav, additional, Jovin, Tudor, additional, Kallmes, David, additional, Khatri, Pooja, additional, Lees, Kennedy R, additional, López-Cancio, Elena, additional, Majoie, Charles, additional, Marquering, Henk, additional, Narata, Ana Paula, additional, Nogueira, Raul, additional, Ringleb, Peter, additional, Siddiqui, Adnan, additional, Szikora, István, additional, Vale, David, additional, von Kummer, Rüdiger, additional, Yoo, Albert J, additional, Hacke, Werner, additional, and Liebeskind, David S, additional
Published: 2017
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75. D-DIMER AS A PREDICTOR OF LARGE VESSEL OCCLUSION IN ACUTE ISCHEMIC STROKE

Author: López-Cancio, Elena, primary
Published: 2017
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76. Safety and efficacy of thrombectomy in acute ischaemic stroke (REVASCAT): 1-year follow-up of a randomised open-label trial

Author: Dávalos, Antoni, primary, Cobo, Erik, additional, Molina, Carlos A, additional, Chamorro, Angel, additional, de Miquel, M Angeles, additional, Román, Luis San, additional, Serena, Joaquín, additional, López-Cancio, Elena, additional, Ribó, Marc, additional, Millán, Mónica, additional, Urra, Xabier, additional, Cardona, Pere, additional, Tomasello, Alejandro, additional, Castaño, Carlos, additional, Blasco, Jordi, additional, Aja, Lucía, additional, Rubiera, Marta, additional, Gomis, Meritxell, additional, Renú, Arturo, additional, Lara, Blanca, additional, Martí-Fàbregas, Joan, additional, Jankowitz, Brian, additional, Cerdà, Neus, additional, Jovin, Tudor G, additional, Ribó, M., additional, Sanjuan, E., additional, Rubiera, M., additional, Pagola, J., additional, Flores, A., additional, Muchada, M., additional, Meler, P., additional, Huerga, E., additional, Gelabert, S., additional, Coscojuela, P., additional, Tomasello, A., additional, Rodriguez, D., additional, Santamarina, E., additional, Maisterra, O., additional, Boned, S., additional, Seró, L., additional, Rovira, A., additional, Molina, C., additional, Millán, M., additional, Muñoz, L., additional, de la Ossa, N. Pérez, additional, Gomis, M., additional, Dorado, L., additional, López-Cancio, E., additional, Palomeras, E., additional, Munuera, J., additional, García Bermejo, P., additional, Remollo, S., additional, Castaño, C., additional, García-Sort, R., additional, Cuadras, P., additional, Puyalto, P., additional, Hernández-Pérez, M., additional, Jiménez, M., additional, Martínez-Piñeiro, A., additional, Lucente, G., additional, Dávalos, A., additional, Chamorro, A., additional, Urra, X., additional, Obach, V., additional, Cervera, A., additional, Amaro, S., additional, Llull, L., additional, Codas, J., additional, Balasa, M., additional, Navarro, J., additional, Ariño, H., additional, Aceituno, A., additional, Rudilosso, S., additional, Renu, A., additional, Macho, J.M., additional, San Roman, L., additional, Blasco, J., additional, López, A., additional, Macías, N., additional, Cardona, P., additional, Quesada, H., additional, Rubio, F., additional, Cano, L., additional, Lara, B., additional, de Miquel, M.A., additional, Aja, L., additional, Jovin, T.G., additional, Serena, J., additional, San Román, L., additional, Cobo, E., additional, Albers, G., additional, Lees, K., additional, Arenillas, J., additional, Roberts, R., additional, Goyal, M., additional, Demchuk, A.M., additional, Minhas, P, additional, Al-Ajlan, F, additional, Salluzzi, M, additional, Zimmel, L, additional, Patel, S, additional, Eesa, M, additional, von Kummer, R., additional, Martí-Fàbregas, J., additional, Jankowitz, B., additional, Salvat-Plana, M., additional, and Hernandez-Pérez, M., additional
Published: 2017
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77. Analyses of thrombi in cerebral arteries with endovascular thrombectomy for acute ischemic stroke: A consensus statement

Author: Liebeskind, David S., primary, De Meyer, Simon F., additional, Andersson, Tommy, additional, Baxter, Blaise, additional, Bendszus, Martin, additional, Brouwer, Patrick, additional, Brinjikji, Waleed, additional, Campbell, Bruce, additional, Costalat, Vincent, additional, Dávalos, Antoni, additional, Demchuk, Andrew, additional, Dippel, Diederik, additional, Fiehler, Jens, additional, Fischer, Urs, additional, Gilvarry, Michael, additional, Gounis, Matt, additional, Gralla, Jan, additional, Jansen, Olav, additional, Jovin, Tudor, additional, Kallmes, David, additional, Khatri, Pooja, additional, Lees, Kennedy, additional, López-Cancio, Elena, additional, Majoie, Charles, additional, Marquering, Henk, additional, Narata, Ana Paula, additional, Nogueira, Raul, additional, Ringleb, Peter, additional, Siddiqui, Adnan, additional, Szikora, István, additional, Vale, David, additional, von Kummer, Rüdiger, additional, Yoo, Albert, additional, and Hacke, Werner, additional
Published: 2017
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78. Impacto de la actividad física previa en el pronóstico y la neurorreparación del ictus isquémico agudo por oclusión de la arteria cerebral media o de la arteria carótida interna intracraneal : factores de crecimiento neuronal y endotelial

Author: Dávalos, Antoni, López-Cancio, Elena, Rey-Joly Barroso, C., Ricciardi Ciocchini, Ana Clara, Universitat Autònoma de Barcelona. Departament de Medicina, Dávalos, Antoni, López-Cancio, Elena, Rey-Joly Barroso, C., Ricciardi Ciocchini, Ana Clara, and Universitat Autònoma de Barcelona. Departament de Medicina
Abstract: La práctica habitual de actividad física (AcF) aporta beneficios en la salud, en especial en la prevención de enfermedades cardio y cerebrovasculares. La AcF parece tener un efecto más allá de la disminución de la incidencia y recurrencia del ictus, existiendo algunos estudios que la asocian a menor gravedad inicial del ictus y a mejor pronóstico funcional, aunque los estudios clínicos publicados son escasos y metodológicamente heterogéneos. Sólo estudios experimentales han relacionado la AcF con un menor volumen de la lesión isquémica, y ningún estudio experimental o clínico ha estudiado su relación con la recanalización arterial en el ictus agudo. Se cree que la práctica de AcF se comporta como un precondicionante de la isquemia, favoreciendo la tolerancia a la misma una vez que se produce, gracias a mecanismos de neuroprotección y neurorreparación. Aunque las vías exactas de señalización molecular y celular a través de las cuales la AcF aporta dichos beneficios son desconocidas, existen una serie de intermediaros implicados en procesos de vasculogénesis, angiogénesis, arteriogénesis y neurogénesis que aparecen de forma constante en la literatura en relación, por un lado, a la práctica de AcF y, por otro lado, en respuesta a la isquemia cerebral, como son las EPCs circulantes y algunos factores de crecimiento neuronal y vascular tales como los VEGF, G-CSF y BDNF. Sin embargo, no existen hasta el momento estudios clínicos en pacientes con ictus isquémico que analicen simultáneamente el papel de la AcF previa y de los citados intermediarios moleculares en el pronóstico clínico y radiológico del ictus. En este estudio prospectivo de pacientes con ictus agudo ( 12h) con oclusión de la ACM o TICA se ha observado que niveles elevados de AcF previo al ictus se asocian a menor gravedad neurológica al ingreso, a mayor tasa de recanalización arterial precoz tras tratamiento fibrinolítico endovenoso, a mejoría dramática precoz, a menor volumen final del infarto y a mejor pro, Regular physical activity (PhA) is beneficial for health, it is especially associated with the prevention of heart and brain vascular diseases. However PhA seems to have an effect beyond the decrease of stroke risk and recurrence, some studies suggest prestroke PhA is associated with lower stroke severity and better functional outcome, though there are only a few published clinical studies with heterogeneous methodology. Only experimental studies have related prestroke PhA with smaller infarct volume, though no studies in animal models or humans have evaluated its effect on arterial recanalization in acute stroke. Prestroke PhA seems to have a preconditioning effect on ischemia, favouring its tolerance once it is initiated, through neuroprotection and neurorepair mechanisms. Though it is unknown the exact molecular and cellular paths that take place in the prestroke PhA beneficial effects, there are a series of intermediaries involved in neovascularization and neurogenesis that constantly come out related with regular PhA practice or brain ischemia, as EPCs and some endothelial and neuronal growth factors like VEGF, G-CSF and BDNF. However, at the moment there are no clinical studies in humans with ischemic stroke that evaluate simultaneously the effect of prestroke PhA and the aforementioned intermediaries on the stroke clinical and radiological prognosis. This prospective study performed in acute stroke patients ( 12h) with MCA or TICA occlusion has observed that higher levels of prestroke PhA is associated with lower stroke severity at admission, higher rate of early arterial recanalization in patients treated with intravenous thrombolysis, early dramatic improvement, smaller infarct volume and better third month functional outcome, in addition to this it is also associated with a higher increase of VEGF on the seventh day after stroke onset. Likewise, a higher increase of VEGF on the seventh day after stroke onset was independently associated to a better third m
Published: 2017

79. Endovascular treatment improves cognition after stroke: a secondary analysis of REVASCAT trial

Author: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Jovin, Tudor G., Cobo Valeri, Erik, Cerdà, Neus, Jiménez, Marta, Gomis Cortina, Meritxell, Hernández Pérez, María, Cáceres, Cynthia, Cardona, Pere, Lara, Blanca, Renú, Arturo, Llull, Laura, Boned, Sara, Muchada, Marián, Dávalos Errando, Antoni, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Jovin, Tudor G., Cobo Valeri, Erik, Cerdà, Neus, Jiménez, Marta, Gomis Cortina, Meritxell, Hernández Pérez, María, Cáceres, Cynthia, Cardona, Pere, Lara, Blanca, Renú, Arturo, Llull, Laura, Boned, Sara, Muchada, Marián, and Dávalos Errando, Antoni
Abstract: Peer Reviewed, Postprint (author's final draft)
Published: 2017

80. Reported prestroke physical activity is associated with vascular endothelial growth factor expression and good outcomes after stroke

Author: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Ricciardi, Anna Clara, Sobrino, Tomás, Cortés Martínez, Jordi, Pérez de la Ossa, Natalia, Millán, Mònica, Hernández Pérez, María, Gomis Cortina, Meritxell, Dorado, Laura, Muñoz Narbona, Lucía, Campos, Francisco, Arenillas, Juan Francisco, Dávalos Errando, Antoni, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Ricciardi, Anna Clara, Sobrino, Tomás, Cortés Martínez, Jordi, Pérez de la Ossa, Natalia, Millán, Mònica, Hernández Pérez, María, Gomis Cortina, Meritxell, Dorado, Laura, Muñoz Narbona, Lucía, Campos, Francisco, Arenillas, Juan Francisco, and Dávalos Errando, Antoni
Abstract: Physical activity (PhA) prior to stroke has been associated with good outcomes after the ischemic insult, but there is scarce data on the involved molecular mechanisms. Methods: We studied consecutive acute ischemic stroke patients admitted to a single tertiary stroke center. Pre-stroke PhA was evaluated with the International Physical Activity Questionnaire (METS-minute/week). We studied several circulating angiogenic and neurogenic factors at different time-points: Vascular Endothelial Growth Factor (VEGF), Granulocyte Colony-Stimulating Factor (G-CSF) and Brain-Derived Neurotrophic Factor (BDNF) at admission, day 7, and at 3 months. We considered good functional outcome at 3 months (mRS = 2) as primary endpoint, and final infarct volume as secondary outcome. Results: We studied 83 patients with at least two time-point serum determinations (mean age 69.6 years, median NIHSS 17 at admission). Patients more physically active before stroke had a significantly higher increment of serum Vascular Endothelial Growth Factor (VEGF) at 7th day when compared to less active patients. This increment was an independent predictor of good functional outcome at 3 months and was associated with smaller infarct volume in multivariate analyses adjusted for relevant covariates. We did not find independent associations of G-CSF or BDNF levels neither with level of pre-stroke PhA nor with stroke outcomes. Conclusions: Although there are probably more molecular mechanisms by which physical activity exerts its beneficial effects in stroke outcomes, our observation regarding the potential role of VEGF is plausible and in line with previous experimental studies. Further research in this field is needed., Peer Reviewed, Postprint (author's final draft)
Published: 2017

81. Safety and efficacy of thrombectomy in acute ischaemic stroke (REVASCAT): 1-year follow-up of a randomised open-label trial

Author: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Dávalos Errando, Antoni, Cobo Valeri, Erik, Molina, Carlos A., Chamorro, Ángel, de Miquel, Maria Angeles, San Román, L., Serena Leal, Joaquín, López-Cancio, Elena, Ribó, Marc, Millán, Mónica, Urra, Xabier, Cardona, Pere, Tomasello, Alejandro, Castaño, Carlos, Blasco, Jordi, Aja, Lucia, Rublera, Marta, Gomis Cortina, Meritxell, Renú, Arturo, Lara, Blanca, Fàbregas, Joan Martí, Jankowitz, Brian, Cerdà, Neus, Jovin, Tudor G., Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, Dávalos Errando, Antoni, Cobo Valeri, Erik, Molina, Carlos A., Chamorro, Ángel, de Miquel, Maria Angeles, San Román, L., Serena Leal, Joaquín, López-Cancio, Elena, Ribó, Marc, Millán, Mónica, Urra, Xabier, Cardona, Pere, Tomasello, Alejandro, Castaño, Carlos, Blasco, Jordi, Aja, Lucia, Rublera, Marta, Gomis Cortina, Meritxell, Renú, Arturo, Lara, Blanca, Fàbregas, Joan Martí, Jankowitz, Brian, Cerdà, Neus, and Jovin, Tudor G.
Abstract: Peer Reviewed, Postprint (author's final draft)
Published: 2017

82. Abstract 42: Blood Biomarkers Refect Tissue Viability in Acute Ischemic Stroke

Author: Bustamante, Alejandro, primary, Terceño, Mikel, additional, Giralt, Dolors, additional, van Eendenburg, Cecile, additional, López-Cancio, Elena, additional, Cardona, Pere, additional, García-Berrocoso, Teresa, additional, Canovas, David, additional, Garces, Moises, additional, Rubiera, Marta, additional, Baldrich, Eva, additional, Castellanos, Mar, additional, Serena, Joaquín, additional, Dávalos, Antoni, additional, and Montaner, Joan, additional
Published: 2017
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83. Abstract WP251: Telestroke 2.0 in Catalonia: More Patients Treated and Secondary Transfers Reduced

Author: Gomis, Meritxell, primary, López-Cancio, Elena, additional, Perez de la Ossa, Natalia, additional, Cardona, Pere, additional, Ribó, Marc, additional, Serena, Joaquin, additional, Purroy, Francisco, additional, Garcés, Moisés, additional, López, Mercè, additional, Soteras, Iñigo, additional, Aragonés, Josep Maria, additional, Cocho, Dolores, additional, Palomeras, Ernest, additional, Villagrasa, David, additional, Puiggrós, Elsa, additional, Catena, Ester, additional, Sanjurjo, Eduard, additional, López Claverol, Núria, additional, Carrión, Dolors, additional, Abilleira, Sònia, additional, and Dávalos, Antoni, additional
Published: 2017
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84. Abstract 67: Blood Biomarkers for Prediction of Cardiac Complications in the Stroke Unit

Author: Bustamante, Alejandro, primary, López-Cancio, Elena, additional, Giralt, Dolors, additional, Cardona, Pere, additional, García-Berrocoso, Teresa, additional, Canovas, David, additional, Garces, Moises, additional, Terceño, Mikel, additional, Serena, Joaquín, additional, Baldrich, Eva, additional, Rubiera, Marta, additional, Dávalos, Antoni, additional, and Montaner, Joan, additional
Published: 2017
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85. Headache Rounds: Orthostatic Headache Complicated by Transient Right Hemisensory Loss

Author: Planas-Ballvé, Anna, primary, Da Silva, Carlos, additional, Martin, Lorena, additional, Broto, Joaquin, additional, Crespo-Cuevas, A.M., additional, López-Cancio, Elena, additional, Munuera, Josep, additional, Millán, Mónica, additional, and Dávalos, Antoni, additional
Published: 2017
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86. Endovascular treatment improves cognition after stroke

Author: López-Cancio, Elena, primary, Jovin, Tudor G., additional, Cobo, Erik, additional, Cerdá, Neus, additional, Jiménez, Marta, additional, Gomis, Meritxell, additional, Hernández-Pérez, María, additional, Cáceres, Cynthia, additional, Cardona, Pere, additional, Lara, Blanca, additional, Renú, Arturo, additional, Llull, Laura, additional, Boned, Sandra, additional, Muchada, Marian, additional, and Dávalos, Antoni, additional
Published: 2016
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87. Fluctuating locked-in syndrome as a presentation of a bilateral pontine infarction

Author: García-Esperón, Carlos, primary, López-Cancio, Elena, additional, Martín-Aguilar, Lorena, additional, Millán, Mónica, additional, Castaño, Carlos, additional, Munuera, Josep, additional, and Dávalos, Antoni, additional
Published: 2016
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88. Recurrent Stroke with Rapid Development of Intracranial Stenoses in Polycythemia Vera

Author: Crespo, Ane M., primary, Abraira, Laura, additional, Guanyabens, Nicolau, additional, Millán, Mónica, additional, Munuera, Josep, additional, Dávalos, Antoni, additional, and López-Cancio, Elena, additional
Published: 2016
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89. Hemodynamic Markers in the Anterior Circulation as Predictors of Recurrent Stroke in Patients With Intracranial Stenosis.

Author: Wabnitz, Ashley M., Derdeyn, Colin P., Fiorella, David J., Lynn, Michael J., Cotsonis, George A., Liebeskind, David S., Waters, Michael F., Lutsep, Helmi, López-Cancio, Elena, Turan, Tanya N., Montgomery, Jean, Janis, L. Scott, Lane, Bethany, Chimowitz, Marc I., and SAMMPRIS Investigators
Published: 2019
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90. Direct mechanical thrombectomy in tPA-ineligible and -eligible patients versus the bridging approach: a meta-analysis.

Author: Kaesmacher, Johannes, Mordasini, Pasquale, Arnold, Marcel, López-cancio, Elena, Cerdá, Neus, Boeckh-Behrens, Tobias, Kleine, Justus F., Goyal, Mayank, Hill, Michael D., Pereira, Vitor Mendes, Saver, Jeffrey L., Gralla, Jan, and Fischer, Urs
Subjects: CEREBRAL ischemia, CONFIDENCE intervals, DISEASE complications, META-analysis, REPERFUSION, STROKE, THROMBOSIS, TISSUE plasminogen activator, VEIN surgery, SYSTEMATIC reviews, EFFECT sizes (Statistics), TREATMENT effectiveness, ODDS ratio
Abstract: Background Whether pretreatment with intravenous thrombolysis prior to mechanical thrombectomy (IVT+MTE) adds additional benefit over direct mechanical thrombectomy (dMTE) in patients with large vessel occlusions (LVO) is a matter of debate. Methods This study-level meta-analysis was presented in accord with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pooled effect sizes were calculated using the inverse variance heterogeneity model and displayed as summary Odds Ratio (s0R) and corresponding 95% confidence interval (95% Cl). Sensitivity analysis was performed by distinguishing between studies including dMTE patients eligible for IVT (IVT-E) or ineligible for IVT (IVT-IN). Primary outcome measures were functional independence (modified Rankin Scale ≤2) and mortality at day 90, successful reperfusion, and symptomatic intracerebral hemorrhage. Results Twenty studies, incorporating 5279 patients, were included. There was no evidence that rates of successful reperfusion differed in dMTE and IVT+MTE patients (sOR 0.93, 95% Cl 0.68 to 1.28). In studies including IVT-IN dMTE patients, patients undergoing dMTE tended to have lower rates of functional independence and had higher odds for a fatal outcome as compared with IVT+MTE patients (sOR 0.78, 95% Cl 0.61 to 1.01 and sOR 1.45, 95% CI 1.22 to 1.73). However, no such treatment group effect was found when analyses were confined to cohorts with a lower risk of selection bias (including IVT-E dMTE patients). Conclusion The quality of evidence regarding the relative merits of IVT+MTE versus dMTE is low. When considering studies with lower selection bias, the data suggest that dMTE may offer comparable safety and efficacy as compared with IVT+MTE. The conduct of randomized-controlled clinical trials seems justified. [ABSTRACT FROM AUTHOR]
Published: 2019
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91. Telestroke in Catalonia: Increasing Thrombolysis Rate and Avoiding Interhospital Transfers.

Author: López-Cancio, Elena, Ribó, Marc, Cardona, Pere, Serena, Joaquín, Purroy, Francisco, Palomeras, Ernest, Aragonès, Josep Maria, Cocho, Dolores, Garcés, Moisés, Puiggròs, Elsa, Soteras, Iñigo, Cabanelas, Ana, Villagrasa, David, Catena, Ester, Sanjurjo, Eduard, López Claverol, Nuria, Carrión, Dolors, López, Mercè, Abilleira, Sònia, and Dávalos, Antoni
Subjects: *STROKE treatment, *THROMBOLYTIC therapy, *TELEMEDICINE
Abstract: Objectives: The study aimed to evaluate the impact of a telestroke network on acute stroke care in Catalonia, by measuring thrombolysis rates, access to endovascular treatment, and clinical outcome of telestroke patients in a population-based study. Methods: Telestroke network was implemented on March 2013 and consists of 12 community hospitals and 1 expert stroke neurologist 24 h/7 day, covering a population of 1.3 million inhabitants. Rest of the population (6.2 million) of Catalonia is covered by 8 primary stroke centers (PSC) and 6 comprehensive stroke centers (CSC). After a 2-way videoconference and visualization of neuroimaging on a web platform, the stroke neurologist decides the therapeutic approach and/or to transfer the patient to another facility, entering these data in a mandatory registry. Simultaneously, all patients treated with reperfusion therapies in all centers of Catalonia are prospectively recorded in a mandatory and audited registry. Results: From March 2013 to December 2015, 1,206 patients were assessed by telestroke videoconference, of whom 322 received intravenous thrombolysis (IVT; 33.8% of ischemic strokes). Baseline and 24 h NIHSS, rate of symptomatic hemorrhage, mortality, and good outcome at 3 months were similar compared to those who received IVT in PSC or CSC (2,897 patients in the same period). The door-to-needle time was longer in patients treated through telestroke, but was progressively reduced from 2013 to 2015. Percentage of patients receiving thrombectomy after IVT was similar in patients treated through telestroke circuit, compared to those treated in PSC or CSC (conventional circuit). Population rates of IVT*100,000 inhabitants in Catalonia increased from 2011 to 2015, especially in areas affected by the implementation of telestroke network, achieving rates as high as 16 per 100,000 inhabitants. Transfers to another facility were avoided after telestroke consultation in 46.8% of ischemic, 76.5% of transient ischemic attacks, and 23.5% of hemorrhages. Conclusions: Telestroke favors safe and effective thrombolysis, helps to increase the population rate of IVT, and avoids a large number of interhospital transfers. [ABSTRACT FROM AUTHOR]
Published: 2018
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92. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment

Author: Gallego-Fabrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martin-Campos, Jesús M., Sobrino, Tomás, Castillo, José, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Ribó, Marc, Alvarez-Sabin, Jose, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan F., Segura, Tomas, Serrano-Heras, Gemma, Marti-Fabregas, Joan, Freijo-Guerrero, Marimar, Moniche, Francisco, Castellanos, Maria del Mar, Morrison, Alanna C., Smith, Nicholas L., de Vries, Paul S., Fernández-Cadenas, Israel, Sabater-Lleal, Maria, Dehghan, Abbas, Heath, Adam S., Morrison, Alanna C., Reiner, Alex P., Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M., Hayward, Caroline, Ward-Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P., Tregouet, David A., Mook-Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W., Leebeek, Frank W.G., Rosendaal, Frits R., Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A., Bressler, Jan, Huffman, Jennifer E., Rotter, Jerome I., Yao, Jie, Wilson, James F., Bis, Joshua C., Hahn, Julie M., Desch, Karl C., Wiggins, Kerri L., Díez-Ahijado, Laia, Raffield, Laura M., Bielak, Lawrence F., Yanek, Lisa R., Kleber, Marcus E., Sabater-Lleal, Maria, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Conomos, Matthew P., Liu, Melissa, Brown, Michael R., Jhun, Min-A, Chen, Ming-Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L., Peyser, Patricia A., Elliot, Paul, de Vries, Paul S., Wei, Peng, Wild, Philipp S., Morange, Pierre E., van der Harst, Pim, Yang, Qiong, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M., Cox, Simon R., Trompet, Stella, Felix, Stephan B., Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, and Guo, Xiuqing
Abstract: Thrombolytic recombinant tissue plasminogen activator (r-tPA) treatment is the only pharmacologic intervention available in the ischemic stroke acute phase. This treatment is associated with an increased risk of intracerebral hemorrhages, known as hemorrhagic transformations (HTs), which worsen the patient’s prognosis.
Published: 2024
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93. Comparison between audio and video based modalities of central modified Rankin score (MRS) adjudication within a prospective, randomized trial on endovascular treatment for acute stroke

Author: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Salvat, Mercé, Roldán, N., Cerda, N., Jimenez, M., Codas, Javier, Llull, L., Boned, Sara, Molina, C., Cano, L., Lara, B., Cobo Valeri, Erik, Dávalos Errando, Antoni, Jovin, Tudor G., Serena Leal, Joaquín, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Salvat, Mercé, Roldán, N., Cerda, N., Jimenez, M., Codas, Javier, Llull, L., Boned, Sara, Molina, C., Cano, L., Lara, B., Cobo Valeri, Erik, Dávalos Errando, Antoni, Jovin, Tudor G., and Serena Leal, Joaquín
Abstract: Peer Reviewed, Postprint (author's final draft)
Published: 2015

94. Phone and video-based modalities of central blinded adjudication of modified rankin scores in an endovascular stroke trial

Author: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Salvat, Mercé, Cerda, Neus, Jimenez, Marta, Codas, Javier, Llull, Laura, Boned, Sara, Cano, Luis M., Blanca, Lara, Molina, Carlos, Cobo Valeri, Erik, Dávalos Errando, Antoni, Jovin, Tudor G., Serena Leal, Joaquín, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica, López-Cancio, Elena, Salvat, Mercé, Cerda, Neus, Jimenez, Marta, Codas, Javier, Llull, Laura, Boned, Sara, Cano, Luis M., Blanca, Lara, Molina, Carlos, Cobo Valeri, Erik, Dávalos Errando, Antoni, Jovin, Tudor G., and Serena Leal, Joaquín
Abstract: Background and Purpose-The standard outcome measure in stroke research is modified Rankin scale (mRS) evaluated by local blinded investigators. We aimed to assess feasibility and reliability of 2 central adjudication methods of mRS in the setting of a randomized endovascular stroke trial. Methods-This is a secondary analysis derived from the Randomized Trial of Revascularization With Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours of Symptom Onset (REVASCAT) trial cohort. Primary outcome was distribution of mRS at 90 days. Local evaluation was done by certified investigators masked to treatment assignment using structured face-to-face interviews. In addition, central assessment was performed by 2 independent raters via structured phone interview (n=120) and via video recordings of the face-to-face interviews with local investigators (n=106). Interrater agreement was evaluated using kappa and discordance statistics. Sensitivity analyses for the primary end point using different adjudication approaches were performed. Correlation between mRS obtained with each modality and 24-hour follow-up infarct volumes was studied. Results-Using local evaluation as the reference, higher agreement rates were noted with central video than with central phone evaluations (k(w) 0.92 [0.88-0.96] versus 0.77 [0.72-0.83]). Discrepancies in mRS scoring between local and central raters (phone- and video-based) were similar in both treatment allocation arms. Sensitivity analyses showed benefit of endovascular treatment irrespective of adjudication method, but higher odds ratios were observed with local evaluations. Final infarct volume was similarly correlated with mRS across all 3 evaluation modalities. Conclusions-Central adjudication of mRS is feasible, reducing interrater variability and avoiding potential problems related to lack of blinding. Our findings may have implicatio, Peer Reviewed, Postprint (author's final draft)
Published: 2015

95. O2-2-1 - Analyses of thrombi in cerebral arteries with endovascular thrombectomy for acute ischemic stroke: A consensus statement

Author: Liebeskind, David S., De Meyer, Simon F., Andersson, Tommy, Baxter, Blaise, Bendszus, Martin, Brouwer, Patrick, Brinjikji, Waleed, Campbell, Bruce, Costalat, Vincent, Dávalos, Antoni, Demchuk, Andrew, Dippel, Diederik, Fiehler, Jens, Fischer, Urs, Gilvarry, Michael, Gounis, Matt, Gralla, Jan, Jansen, Olav, Jovin, Tudor, Kallmes, David, Khatri, Pooja, Lees, Kennedy, López-Cancio, Elena, Majoie, Charles, Marquering, Henk, Narata, Ana Paula, Nogueira, Raul, Ringleb, Peter, Siddiqui, Adnan, Szikora, István, Vale, David, von Kummer, Rüdiger, Yoo, Albert, and Hacke, Werner
Published: 2017
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96. Structural Integrity of the Contralesional Hemisphere Predicts Cognitive Impairment in Ischemic Stroke at Three Months

Author: Ciencia de la computación e inteligencia artificial, Konputazio zientziak eta adimen artifiziala, Dacosta Aguayo, Rosalía, Graña Romay, Manuel María, Fernández Andujar, Marina, López Cancio, Elena, Cáceres, Cynthia, Bargallo, Nuria, Barrios, Maite, Clemente, Immaculada, Toran Monserrat, Pere, Alzamora Sas, Maite, Davalos, Antoni, Auer, Tibor, Mataró, María, Ciencia de la computación e inteligencia artificial, Konputazio zientziak eta adimen artifiziala, Dacosta Aguayo, Rosalía, Graña Romay, Manuel María, Fernández Andujar, Marina, López Cancio, Elena, Cáceres, Cynthia, Bargallo, Nuria, Barrios, Maite, Clemente, Immaculada, Toran Monserrat, Pere, Alzamora Sas, Maite, Davalos, Antoni, Auer, Tibor, and Mataró, María
Abstract: After stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of the contralateral hemisphere is associated with degree of functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) and eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) and neuropsychological assessment. The stroke patient group was divided into poor (SP; n = 8) and good (SG; n = 6) cognitive recovery groups according to their cognitive improvement from the acute phase (72 hours after stroke) to the subacute phase (3 months post-stroke). Whole-brain DWI data analysis was performed by computing Diffusion Tensor Imaging (DTI) followed by Tract Based Spatial Statistics (TBSS). Assessment of effects was obtained computing the correlation of the projections on TBSS skeleton of Fractional Anisotropy (FA) and Radial Diffusivity (RD) with cognitive test results. Significant decrease of FA was found only in right brain anatomical areas for the S group when compared to the HC group. Analyzed separately, stroke patients with poor cognitive recovery showed additional significant FA decrease in several left hemisphere regions; whereas SG patients showed significant decrease only in the left genu of corpus callosum when compared to the HC. For the SG group, whole brain analysis revealed significant correlation between the performance in the Semantic Fluency test and the FA in the right hemisphere as well as between the performance in the Grooved Pegboard Test (GPT) and theTrail Making Test-part A and the FA in the left hemisphere. For the SP group, correlation analysis revealed significant correlation between the performance in the GPT and the FA in the right hemisphere. Palabras clave
Published: 2014

97. Impairment of functional integration of the default mode network correlates with cognitive outcome at three months after stroke

Author: Dacosta‐Aguayo, Rosalia, primary, Graña, Manuel, additional, Iturria‐Medina, Yasser, additional, Fernández‐Andújar, Marina, additional, López‐Cancio, Elena, additional, Cáceres, Cynthia, additional, Bargalló, Núria, additional, Barrios, Maite, additional, Clemente, Immaculada, additional, Toran, Pera, additional, Forés, Rosa, additional, Dávalos, Antoni, additional, Auer, Tibor, additional, and Mataró, Maria, additional
Published: 2014
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98. Circadian rhythms in the efficacy of intravenous alteplase in patients with acute ischemic stroke and middle cerebral artery occlusion

Author: Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Vilas, D., Gomis Cortina, Meritxell, Blanco, Miguel, Cortés Martínez, Jordi, Millán Torné, Mònica, De La Ossa, Natalia Pérez, Dorado, Laura, López Cancio, Elena, Suñol, A., Dávalos Errando, Antoni, Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, Vilas, D., Gomis Cortina, Meritxell, Blanco, Miguel, Cortés Martínez, Jordi, Millán Torné, Mònica, De La Ossa, Natalia Pérez, Dorado, Laura, López Cancio, Elena, Suñol, A., and Dávalos Errando, Antoni
Abstract: Circadian rhythm interactions of hemostatic factors can modify tissue plasminogen activator (tPA) effects. We assess the relationship of the time frame of intravenous tPA administration with the outcome of patients with acute ischemic stroke (AIS). We studied 135 consecutive patients with AIS and transcranial duplex documented middle cerebral artery (MCA) occlusion treated with intravenous tPA. Complete recanalization was defined as total improvement on thrombolysis in brain ischemia (TIBI) grades 2 h after tPA infusion. Clinical response was evaluated by the modified Rankin scale at 90 days. We determined plasminogen activator inhibitor-1 (PAI-1) levels in 33 patients with available plasma samples before treatment. Our results are follows: 92 (68.1%) patients were treated in the diurnal (9:00–21:00) and 43 (31.8%) in the nocturnal period (21:00–9:00). Complete recanalization was recorded in 52/135 (38.5%) patients. Both the rate of complete recanalization (45.6% vs. 23.2%; p = .01) and good clinical outcome (64.1% vs. 44.2%; p = .02) were significantly higher in the group of diurnal tPA administration compared with those treated in the nocturnal period. The adjusted odds ratio (OR) of diurnal tPA treatment for complete MCA recanalization was 2.37 (95% confidence interval [CI], 1.02–5.52; p = .045). Diurnal tPA infusion significantly improved the overall distribution of scores on the modified Rankin scale, as compared with nocturnal treatment (OR, 2.07; 95% CI, 1.16–4.64 by ordinal regression analysis). Low PAI-1 levels were associated with complete recanalization but did not significantly differ between the two time frames. In conclusion, diurnal administration of tPA is associated with complete MCA recanalization and better functional outcome at 90 days in patients with AIS., Peer Reviewed, Postprint (author's final draft)
Published: 2012

99. Abstract W P11: A Clinical Scale to Predict Futile Arterial Recanalization in Acute Stroke Patients with Anterior Circulation Arterial Occlusion Treated with Endovascular Therapies.

Author: Perez de la Ossa, Natalia, primary, Hernández-Pérez, Maria, additional, Millán, Monica, additional, Gomis, Meritxell, additional, López-Cancio, Elena, additional, Dorado, Laura, additional, García-Bermejo, Pablo, additional, Castaño, Carlos, additional, and Dávalos, Antoni, additional
Published: 2014
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100. Abstract 73: Resistance to Iv Thrombolysis and Prognostic Impact of Metabolic Syndrome in Middle Cerebral Artery Ischemic Stroke

Author: Dorado, Laura, primary, Arenillas, Juan F, additional, López-Cancio, Elena, additional, Hernández-Pérez, María, additional, Pérez de la Ossa, Natàlia, additional, Gomis, Meritxell, additional, Millán, Mònica, additional, Galán, Amparo, additional, and Dávalos, Antonio, additional
Published: 2014
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