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We compare the ocean temperature evolution of the Holocene as simulated by climate models and reconstructed from marine temperature proxies. We use transient simulations from a coupled atmosphere-ocean general circulation model, as well as an ensemble of time slice simulations from the Paleoclimate Modelling Intercomparison Project. The general pattern of sea surface temperature (SST) in the models shows a high-latitude cooling and a low-latitude warming. The proxy dataset comprises a global compilation of marine alkenone- and Mg/Ca-derived SST estimates. Independently of the choice of the climate model, we observe significant mismatches between modelled and estimated SST amplitudes in the trends for the last 6000 yr. Alkenone-based SST records show a similar pattern as the simulated annual mean SSTs, but the simulated SST trends underestimate the alkenone-based SST trends by a factor of two to five. For Mg/Ca, no significant relationship between model simulations and proxy reconstructions can be detected. We test if such discrepancies can be caused by too simplistic interpretations of the proxy data. We explore whether consideration of different growing seasons and depth habitats of the planktonic organisms used for temperature reconstruction could lead to a better agreement of model results with proxy data on a regional scale. The extent to which temporal shifts in growing season or vertical shifts in depth habitat can reduce model-data misfits is determined. We find that invoking shifts in the living season and habitat depth can remove some of the model-data discrepancies in SST trends. Regardless whether such adjustments in the environmental parameters during the Holocene are realistic, they indicate that when modelled temperature trends are set up to allow drastic shifts in the ecological behaviour of planktonic organisms, they do not capture the full range of reconstructed SST trends. Results indicate that modelled and reconstructed temperature trends are to a

We compare the ocean temperature evolution of the Holocene as simulated by climate models and reconstructed from marine temperature proxies. We use transient simulations from a coupled atmosphere–ocean general circulation model, as well as an ensemble of time slice simulations from the Paleoclimate Modelling Intercomparison Project. The general pattern of sea surface temperature (SST) in the models shows a high-latitude cooling and a low-latitude warming. The proxy dataset comprises a global compilation of marine alkenone- and Mg/Ca-derived SST estimates. Independently of the choice of the climate model, we observe significant mismatches between modelled and estimated SST amplitudes in the trends for the last 6000 yr. Alkenone-based SST records show a similar pattern as the simulated annual mean SSTs, but the simulated SST trends underestimate the alkenone-based SST trends by a factor of two to five. For Mg/Ca, no significant relationship between model simulations and proxy reconstructions can be detected. We test if such discrepancies can be caused by too simplistic interpretations of the proxy data. We explore whether consideration of different growing seasons and depth habitats of the planktonic organisms used for temperature reconstruction could lead to a better agreement of model results with proxy data on a regional scale. The extent to which temporal shifts in growing season or vertical shifts in depth habitat can reduce model–data misfits is determined. We find that invoking shifts in the living season and habitat depth can remove some of the model–data discrepancies in SST trends. Regardless whether such adjustments in the environmental parameters during the Holocene are realistic, they indicate that when modelled temperature trends are set up to allow drastic shifts in the ecological behaviour of planktonic organisms, they do not capture the full range of reconstructed SST trends. Results indicate that modelled and reconstructed temperature trends are to a

Microbeam radiation therapy (MRT) has the potential to treat infantile brain tumours when other kinds of radiotherapy would be excessively toxic to the developing normal brain. MRT uses extraordinarily high doses of x-rays but provides unusual resistance to radioneurotoxicity, presumably from the migration of endothelial cells from 'valleys' into 'peaks', i.e., into directly irradiated microslices of tissues. We present a novel irradiation geometry which results in a tolerable valley dose for the normal tissue and a decreased peak-to-valley dose ratio (PVDR) in the tumour area by applying an innovative cross-firing technique. We propose anMRT technique to orthogonally crossfire two arrays of parallel, nonintersecting, mutually interspersed microbeams that produces tumouricidal doses with small PVDRs where the arrays meet and tolerable radiation doses to normal tissues between the microbeams proximal and distal to the tumour in the paths of the arrays.

Microbeam Radiation Therapy (MRT) has the potential to treat infantile brain tumors when other kinds of radiotherapy would be excessively toxic to the developing normal brain. MRT uses extraordinarily high doses of X-rays but provides unusual resistance to radioneurotoxicity, presumably from the rapid migration of regenerative endothelial cells from dose ''valleys'' into dose ''peaks'', i.e., into directly irradiated micro-slices of tissues. We will present a novel irradiation geometry which results in a tolerable valley dose for the normal tissue and a decreased peak-to-valley dose ratio (PVDR) in the tumor area by applying an innovative cross-firing technique. We propose an MRT technique to orthogonally crossfire two arrays of parallel, nonintersecting, mutually interspersed microbeams that produces tumoricidal doses with small PVDRs where the arrays meet and tolerable radiation doses to normal tissues between the microbeams proximal and distal to the tumor in the paths of the arrays.