65 results on '"Leng, Jia"'
Search Results
52. Long Mesentericoportal Vein Resection and End-to-End Anastomosis Without Graft in Pancreaticoduodenectomy
- Author
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Zhang, Ji, primary, Qian, Hong-Gang, additional, Leng, Jia-Hua, additional, Cui, Ming, additional, Qiu, Hui, additional, Zhou, Guo-Quan, additional, Wu, Jian-Hui, additional, Yang, Yong, additional, and Hao, Chun-Yi, additional
- Published
- 2008
- Full Text
- View/download PDF
53. Geometrical Nonlinear Aeroelastic Stability Analysis of a Composite High-Aspect-Ratio Wing
- Author
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Xie, Chang Chuan, primary, Leng, Jia Zhen, additional, and Yang, Chao, additional
- Published
- 2008
- Full Text
- View/download PDF
54. Time to Trigger Selection Scheme Based on Speed Estimation in Small Cell.
- Author
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LENG Jia-li, CAO Yong-min, and WANG Dong-jun
- Subjects
BANDWIDTH research ,ROAMING (Telecommunication) ,WIRELESS communications ,DATA transmission systems ,TELECOMMUNICATION research - Abstract
With the more and more strict requirements for system bandwidth and transmission rate, small cell technology is an effective way to solve indoor and hot scenes coverage and capacity issues. In order to alleviate the contradiction between handover failure probability and ping-pang handover probability well, the handover model in heterogeneous networks is established and UE speed is estimated through using the reference signal received power (RSRP) scheme to track UE moving locus. And then the relationship between handover failure probability (HOF) and ping-pang handover probability (PP) with respect to time to trigger (TTT) and UE speed is derivated and analyzed. Finally, TTT is optimized and selected by using traversal algorithm. Simulation results show that the proposed scheme can reduce handover failure probability close to zero while decreasing the ping-pong handover rate by 10 percent. Therefore, it can alleviate above contradiction well and is more suitable for high-speed UE which is sensitive to ping-pong handover. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
55. Transcriptional Regulations on the Low-Temperature-Induced Floral Transition in an Orchidaceae Species, Dendrobium nobile: An Expressed Sequence Tags Analysis.
- Author
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Shan Liang, Ye, Qing-Sheng, Li, Rui-Hong, Leng, Jia-Yi, Li, Mei-Ru, Wang, Xiao-Jing, and Li, Hong-Qing
- Subjects
ORCHIDS ,TRANSCRIPTION factors ,GENETIC regulation ,PLANT species ,EFFECT of temperature on plants ,GENE expression in plants ,AMINO acid sequence ,VERNALIZATION ,ANGIOSPERMS - Abstract
Vernalization-induced flowering is a cold-relevant adaptation inmany species, but little is known about the genetic basis behind in Orchidaceae species. Here, we reported a collection of 15017 expressed sequence tags (ESTs) from the vernalized axillary buds of an Orchidaceae species, Dendrobium nobile, which were assembled for 9616 unique gene clusters. Functional enrichment analysis showed that genes in relation to the responses to stresses, especially in the formof low temperatures, and those involving in protein biosynthesis and chromatin assembly were significantly overrepresented during 40 days of vernalization. Additionally, a total of 59 putative flowering-relevant genes were recognized, including those homologous to known key players in vernalization pathways in temperate cereals or Arabidopsis, such as cereal VRN1, FT/VRN3, and Arabidopsis AGL19. Results from this study suggest that the networks regulating vernalization-induced floral transition are conserved, but just in a part, in D. nobile, temperate cereals, and Arabidopsis. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
56. Long mesentericoportal vein resection and end-to-end anastomosis without graft in pancreaticoduodenectomy.
- Author
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Ji Zhang, Hong-Gang Qian, Jia-Hua Leng, Ming Cui, Hui Qiu, Guo-Quan Zhou, Jian-Hui Wu, Yong Yang, Chun-Yi Hao, Zhang, Ji, Qian, Hong-Gang, Leng, Jia-Hua, Cui, Ming, Qiu, Hui, Zhou, Guo-Quan, Wu, Jian-Hui, Yang, Yong, and Hao, Chun-Yi
- Subjects
PANCREATICODUODENECTOMY ,ADENOCARCINOMA ,CANCER treatment ,MORTALITY ,THROMBOSIS ,PATIENTS ,PORTAL vein surgery ,MESENTERIC veins ,BLOOD vessel prosthesis ,CARDIOVASCULAR surgery ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,PANCREATIC tumors ,RESEARCH ,EVALUATION research ,RETROSPECTIVE studies ,SURGICAL anastomosis ,SURGERY - Abstract
Introduction: The feasibility and safety of pancreaticoduodenectomy (PD) combined with long segmental mesentericoportal vein (MPV; >5 cm) resection and end-to-end anastomosis without graft has rarely been demonstrated.Materials and Methods: Eight patients with pancreatic head adenocarcinoma underwent PD combined with long MPV resection between August 2006 and May 2008 in Peking University School of Oncology.Results: By liver mobilization and Cattell-Braasch maneuver, direct and tension-free end-to-end anastomosis was easily performed even when the resected segment of the MPV was longer than 5 cm. All the eight patients experienced uneventful recovery without severe complications.Conclusions: PD with long MPV resection and direct end-to-end anastomoses is safe and effective. [ABSTRACT FROM AUTHOR]- Published
- 2009
- Full Text
- View/download PDF
57. Transcriptional Regulations on the Low-Temperature-Induced Floral Transition in an Orchidaceae Species, Dendrobium nobile: An Expressed Sequence Tags Analysis
- Author
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Liang, Shan, Ye, Qing-Sheng, Li, Rui-Hong, Leng, Jia-Yi, Li, Mei-Ru, Wang, Xiao-Jing, and Li, Hong-Qing
- Abstract
Vernalization-induced flowering is a cold-relevant adaptation in many species, but little is known about the genetic basis behind in Orchidaceae species. Here, we reported a collection of 15017 expressed sequence tags (ESTs) from the vernalized axillary buds of an Orchidaceae species, Dendrobium nobile, which were assembled for 9616 unique gene clusters. Functional enrichment analysis showed that genes in relation to the responses to stresses, especially in the form of low temperatures, and those involving in protein biosynthesis and chromatin assembly were significantly overrepresented during 40 days of vernalization. Additionally, a total of 59 putative flowering-relevant genes were recognized, including those homologous to known key players in vernalization pathways in temperate cereals or Arabidopsis, such as cereal VRN1, FT/VRN3, and Arabidopsis AGL19. Results from this study suggest that the networks regulating vernalization-induced floral transition are conserved, but just in a part, in D. nobile, temperate cereals, and Arabidopsis.
- Published
- 2012
- Full Text
- View/download PDF
58. Pan-cancer analysis reveals distinct clinical, genomic, and immunological features of the LILRB immune checkpoint family in acute myeloid leukemia.
- Author
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Xu ZJ, Zhang XL, Jin Y, Wang SS, Gu Y, Ma JC, Wen XM, Leng JY, Mao ZW, Lin J, and Qian J
- Abstract
Leukocyte immunoglobulin (Ig)-like receptor Bs ( LILRB s), a family of type I transmembrane glycoproteins, are known to inhibit immune activation. Here, we comprehensively evaluated the molecular, prognostic, and immunological characteristics of LILRB members in a broad spectrum of cancer types, focusing on their roles in acute myeloid leukemia (AML). We showed that LILRB s were significantly dysregulated in a number of cancers and were associated with immune-inhibitory phenotypes. Clinically, high expression of LILRB1 - LILRB4 predicted poor survival in six independent AML cohorts. Genetically, LILRB1 was associated with more mutational events than other LILRB members, and multiple genes involved in immune activation were deleted in LILRB1
high patients. Epigenetically, LILRB4 was significantly hypomethylated and marked by MLL-associated histone modifications in AML. Immunologically, LILRB s were positively associated with monocytic cells, including M2 macrophages, but were negatively associated with tumor-suppressive CD8 T cells. Importantly, patients with higher LILRB expression generally showed a better response to immune checkpoint blockade (ICB) in five independent immunotherapy cohorts. Our findings reveal critical immunological and clinical implications of LILRB s in AML and indicate that LILRB s may represent promising targets for immunotherapy of AML., Competing Interests: The authors declare that they have no competing interests., (© 2022 The Author(s).)- Published
- 2022
- Full Text
- View/download PDF
59. [Clinical Significance of Low Expression of LncRNA CASC15 in Acute Myeloid Leukemia with NPM1 Mutations].
- Author
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Xia PH, Xu ZJ, Jin Y, Ma JC, Wen XM, Yuan Q, Leng JY, Qian J, and Lin J
- Subjects
- Humans, Mutation, Nuclear Proteins genetics, Prognosis, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute metabolism, Nucleophosmin genetics, RNA, Long Noncoding genetics
- Abstract
AbstractObjective: To identify the expression and methylation patterns of lncRNA CASC15 in bone marrow (BM) samples of acute myeloid leukemia (AML) patients, and further explore its clinical significance., Methods: Eighty-two de novo AML patients and 18 healthy donors were included in the study. Meanwhile, seven public datasets from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were included to confirm the expression and methylation data of CASC15. Receiver operating characteristic (ROC) curve analysis was applied to determine the discriminative capacity of CASC15 expression to identify AML. The patients were divided into CASC15high group and CASC15low group by X-tile method, and the prognostic value of CASC15 was identified by Kaplan-Meier method and univariate and multivariate Cox regression analysis., Results: The expression level of CASC15 was significantly decreased in BM cells of AML patients compared with healthy donors (P<0.001). ROC curve analysis suggested that CASC15 expression might be a potential biomarker to discriminate AML from controls. The expression of CASC15 was high at the early stage of hematopoiesis, and reached a peak at the stage of multipotent progenitors differentiation, then decreased rapidly, and was at a range of low level fluctuations in the subsequent process. Among FAB subtypes, CASC15 expression in M0 was significantly higher than that in M1-M7. Clinically, CASC15low patients were more likely to have NPM1 mutations than CASC15high patients (P=0.048), while CASC15high patients had a significantly higher frequency of IDH1 and RUNX1 mutations (P=0.021 and 0.014, respectively). Moreover, CASC15low group had a shorter overall survival (OS) in patients with NPM1 mutations. Furthermore, multivariate analysis confirmed that CASC15 expression was a significant independent risk factor for OS in NPM1 mutated AML patients. In addition, CASC15 methylation level in BM samples of AML patients was significantly decreased compared with healthy donors. Patients with CASC15 high methylation had poor OS and disease-free survival., Conclusion: The expression of CASC15 is decreased in AML, and low CASC15 expression may predict adverse prognosis in AML patients with NPM1 mutations. Moreover, CASC15 methylation level in AML is significantly decreased, and high CASC15 methylation may predict poor prognosis in AML.
- Published
- 2022
- Full Text
- View/download PDF
60. [Detection of NPM1 Mutation in Acute Myeloid Leukemia by Droplet Digital PCR and Its Clinical Application Value].
- Author
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Jin Y, Wang SS, Xia PH, Yuan Q, Xiao GF, Lin J, Leng JY, Ma YJ, and Qian J
- Subjects
- Humans, Mutation, Nucleophosmin, Polymerase Chain Reaction, Prognosis, Leukemia, Myeloid, Acute therapy, Nuclear Proteins genetics
- Abstract
Objective: To establish the droplet digital PCR (ddPCR) assay for the detection of NPM1 type A mutation in patients with acute myeloid leukemia (AML), and to evaluate its specificity, sensitivity and its value in clinical application., Methods: NPM1 mutant and wildtype plasmids were used to verify the performance of ddPCR. Both ddPCR and Sanger sequencing were used to detect the bone marrow samples of 87 AML patients, which were confirmed by next generation sequencing (NGS). Moreover, NPM1 mutation burden was dynamically monitored in five patients by ddPCR., Results: The limit of blank (LOB) of ddPCR established for NPM1 mutation detection was 1.1 copies/μl, and the limit of detection (LOD) was 2.43 copies/μl, which had good linearity. Among the 87 newly diagnosed AML patients, ddPCR identified seventeen cases positive for NPM1 mutation (19.5%), which was consistent with Sanger sequencing. NGS confirmed 12 positive cases, including 8 of type A mutations, 2 of type D mutations, and 2 of rare type mutations. The results of dynamic monitoring of NPM1 mutation burden in 5 patients showed that the NPM1 mutation burden decreased obviously even close to 0, when patients achieve complete remission after chemotherapy. However, the mutation burden was increased again at the time of relapse., Conclusion: In this study, we established a ddPCR method for detection of NPM1 mutation with good sensitivity and repeatability, which can be used for screening NPM1 mutation in newly diagnosed AML patients and for minimal residual disease monitoring after remission in positive AML patients to guide treatment.
- Published
- 2022
- Full Text
- View/download PDF
61. SOX7 methylation is an independent prognostic factor in myelodysplastic syndromes.
- Author
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Xu ZJ, Tang CY, Zhou JD, Ma JC, Wen XM, Deng ZQ, Leng JY, Qiu ZY, Qian J, and Lin J
- Subjects
- Adult, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Myelodysplastic Syndromes mortality, Myelodysplastic Syndromes pathology, Prognosis, Proportional Hazards Models, Young Adult, DNA Methylation genetics, Myelodysplastic Syndromes genetics, SOXF Transcription Factors genetics
- Abstract
Objective: SOX7 downregulation caused by its promoter methylation was associated with poor survival in several types of human solid tumors. However, the pattern of SOX7 methylation and its clinical significance are less studied in hematological malignancies. Herein, we evaluated the methylation pattern of SOX7 in myelodysplastic syndrome (MDS) and determined its clinical implication in patients with MDS., Methods: SOX7 methylation was determined by real-time quantitative methylation-specific PCR (RQ-MSP) in 99 MDS patients. Bisulfite sequencing PCR was applied to confirm the results of RQ-MSP., Results: SOX7 methylation was detected in 55.6% of 99 patients but not in healthy donors. No correlation was found between SOX7 methylation and clinical parameters including patient age, gender, white blood cell count, hemoglobin, and platelet count. However, patients with SOX7 methylation harbored more U2AF1 mutation than patients without SOX7 methylation (P = 0.015). Kaplan-Meier curves indicated that the patients with SOX7 methylation presented reduced overall survival (OS) (P = 0.034). Furthermore, subgroup analysis indicated that SOX7 methylation was associated with poor OS in male patients (P = 0.034) and in patients older than 60 years (P = 0.019). According to the multivariate analysis, SOX7 methylation remained as an independent prognosis factor in MDS patients both as dichotomous (HR = 2.14, P = 0.041) and as continuous (HR = 1.55, P = 0.042) variable. Importantly, SOX7 methylation was significantly increased during progression from MDS to secondary acute myeloid leukemia (sAML)., Conclusions: Our findings demonstrated that SOX7 methylation conferred adverse prognosis in MDS patients and was associated with leukemia progression., (Copyright © 2018. Published by Elsevier GmbH.)
- Published
- 2019
- Full Text
- View/download PDF
62. Reactive lymphoid hyperplasia of the liver mimicking hepatocellular carcinoma: incidental finding of two cases.
- Author
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Lv A, Liu W, Qian HG, Leng JH, and Hao CY
- Subjects
- B-Lymphocytes immunology, Biomarkers analysis, Biopsy, Diagnosis, Differential, Female, Gene Rearrangement, B-Lymphocyte, Humans, Immunohistochemistry, Liver immunology, Liver surgery, Liver Diseases genetics, Liver Diseases immunology, Liver Diseases surgery, Magnetic Resonance Imaging, Middle Aged, Neprilysin analysis, Predictive Value of Tests, Proto-Oncogene Proteins c-bcl-2 analysis, Pseudolymphoma genetics, Pseudolymphoma immunology, Pseudolymphoma surgery, Receptors, Antigen, B-Cell genetics, B-Lymphocytes pathology, Carcinoma, Hepatocellular pathology, Incidental Findings, Liver pathology, Liver Diseases pathology, Liver Neoplasms pathology, Pseudolymphoma pathology
- Abstract
Reactive lymphoid hyperplasia is a rare disease that forms a mass-like lesion and is characterized by the proliferation of non-neoplastic, polyclonal lymphocytes forming follicles. We recently encountered 2 cases of reactive lymphoid hyperplasia of liver, both of which were asymptomatic and mimicked hepatocellular carcinoma by various imaging modalities. Based on the clinical impression of hepatocellular carcinoma, surgical resections were performed. Microscopic findings revealed that both lesions consisted of an aggregation of lymphocytes consisting of predominantly B-cells, with multiple lymphoid follicles positive for CD10 and negative for bcl-2, consistent with the diagnosis of reactive lymphoid hyperplasia. Polyclonality of both lesions was further confirmed by B cell receptor gene rearrangement study. The incidence of reactive lymphoid hyperplasia in the liver is exceedingly rare, and it is difficult to differentiate such lesions from hepatic malignancies based upon clinical grounds. The clinicopathological findings and literature review of this report may be helpful to improve the clinical decision-making.
- Published
- 2015
63. Transcriptional Regulations on the Low-Temperature-Induced Floral Transition in an Orchidaceae Species, Dendrobium nobile: An Expressed Sequence Tags Analysis.
- Author
-
Liang S, Ye QS, Li RH, Leng JY, Li MR, Wang XJ, and Li HQ
- Abstract
Vernalization-induced flowering is a cold-relevant adaptation in many species, but little is known about the genetic basis behind in Orchidaceae species. Here, we reported a collection of 15017 expressed sequence tags (ESTs) from the vernalized axillary buds of an Orchidaceae species, Dendrobium nobile, which were assembled for 9616 unique gene clusters. Functional enrichment analysis showed that genes in relation to the responses to stresses, especially in the form of low temperatures, and those involving in protein biosynthesis and chromatin assembly were significantly overrepresented during 40 days of vernalization. Additionally, a total of 59 putative flowering-relevant genes were recognized, including those homologous to known key players in vernalization pathways in temperate cereals or Arabidopsis, such as cereal VRN1, FT/VRN3, and Arabidopsis AGL19. Results from this study suggest that the networks regulating vernalization-induced floral transition are conserved, but just in a part, in D. nobile, temperate cereals, and Arabidopsis.
- Published
- 2012
- Full Text
- View/download PDF
64. [Association of hepatitis B virus infection and cirrhosis with liver metastasis in colorectal cancer].
- Author
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Qian HG, Zhang J, Leng JH, Zhou GQ, Wu JH, Tian XY, Yang Y, and Hao CY
- Subjects
- Adult, Aged, Aged, 80 and over, Colorectal Neoplasms virology, Female, Hepatitis B virus, Humans, Liver Neoplasms virology, Male, Middle Aged, Neoplasm Metastasis, Retrospective Studies, Survival Rate, Young Adult, Colorectal Neoplasms pathology, Hepatitis B complications, Liver Cirrhosis complications, Liver Neoplasms secondary
- Abstract
Objective: To explore the relationship of hepatitis B virus (HBV) infection and cirrhosis with liver metastasis in colorectal cancer., Methods: Clinical date of 1176 colorectal cancer patients undergone surgical treatment in the Peking University School of Oncology between January 1999 and August 2004 were analyzed retrospectively to investigate the impact of HBV infection and cirrhosis on the occurrence of liver metastasis and prognosis of patients., Results: The incidence of liver metastasis was 8.8% (10/114) in the HBV infection group and 23.9% (254/1062) in the non-infection group (P<0.01). The 5-year survival rates of these two groups were 54.2% and 60.7% ( P>0.05). The incidence of liver metastasis was 3.8% (1/26) in the cirrhotic group and 22.9% (263/1150) in the non-cirrhotic group (P<0.05). The 5-year survival rates of these two groups were 60.9% and 59.9% ( P>0.05)., Conclusion: Both hepatitis B virus infection and cirrhosis are associated with less liver metastasis in colorectal cancer, but have no impact on the survival.
- Published
- 2010
65. [The influence of abscisic acid treatment on desiccation tolerance in Dendrobium candidum protocorm-like bodies].
- Author
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Liu W, Pan RC, Leng JY, and Ye QS
- Subjects
- Adaptation, Physiological physiology, Dendrobium metabolism, Dendrobium physiology, Desiccation, Plant Growth Regulators pharmacology, Polysaccharides metabolism, Time Factors, Abscisic Acid pharmacology, Adaptation, Physiological drug effects, Dendrobium drug effects
- Abstract
Effect of ABA on desiccation tolerance in the protocorm-like bodies (PLBs) of D. candidum was studied. The best result was obtained while ABA precultured at 5 micromol/L for 24 h (Fig.2). PLBs vitality rate was 10 times of the control after 2 h desiccation (Table 1). Detection of cytoplasmic osmoticums showed that ABA preculture could not induce the accumulations of soluble sugar, proline, etc (Tables 3, 4 and 7). But the content of soluble polysaccharide rose conspicuously (Table 5). So we think that the accumulation of soluble polysaccharide may play an important role in desiccation tolerance induced by ABA preculture.
- Published
- 2006
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